CN105394756A - Compound herba silybi orally disintegrating tablet and preparation method thereof - Google Patents
Compound herba silybi orally disintegrating tablet and preparation method thereof Download PDFInfo
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- CN105394756A CN105394756A CN201510854555.7A CN201510854555A CN105394756A CN 105394756 A CN105394756 A CN 105394756A CN 201510854555 A CN201510854555 A CN 201510854555A CN 105394756 A CN105394756 A CN 105394756A
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a compound herba silybi orally disintegrating tablet. The compound herba silybi orally disintegrating tablet is prepared from, by weight, 20-28 parts of herba silybi honey, 30-35 parts of herba silybi pollen, 33-40 parts of microcrystalline cellulose, 1-5 parts of water soluble propolis, 1-5 parts of normal saline, 0.5-3 parts of rhizoma curcumae longae, 0.5-2 parts of dandelions, 1-1.5 parts of aloe and 1-2 parts of licorice roots. The invention further discloses a preparation method of the compound herba silybi orally disintegrating tablet. According to the compound herba silybi orally disintegrating tablet and the preparation method thereof, dosing is reasonable, good nutritive value and liver-protecting effect are achieved, and particularly for convalescent patients with hepatopathy, a good rehabilitation effect is achieved. The state is stable, the layering phenomenon does not occur, the taste is good, the preparation temperature is not high, the color and luster can be ensured to be unchanged, and light yellow is achieved. The compound herba silybi orally disintegrating tablet is free of preservative, is a healthy, green and pure natural product and is beneficial for body health of a user.
Description
Technical field
The present invention relates to edible health care product, particularly a kind of compound milk thistle oral disintegrating tablet, the invention still further relates to the preparation method of this compound milk thistle oral disintegrating tablet.
Background technology
Silybum 1 year or biennial catananche, be excellent protect liver plant, originate in West Europe and north African.China in Shaanxi, Gansu, Heilungkiang and Hebei etc. economize cultivation, its strong adaptability, tight to soil, moisture requirement, ground, sandy beach, salt-soda soil all can be planted.Herb is used for early stage of pyogenic infection of skin and erysipelas; Fruit and extract are used for hepatopathy, spleen sick gall stone, jaundice and chronic cough.Clearing heat and detoxicating, to protect the liver, cholagogic, protect brain, anti-X-ray.All there is good efficacy to liver, the scorching diseases of courage such as inflammation around acute or chronic hepatitis, cirrhosis, fatty liver, metabolism toxic liver injury, cholelithiasis, cholangitis and hepatic duct, hepatopathy patient subjective symptoms and some biochemical index can be made as serum bilirubin, improvement rapidly such as white Anhui and ball Anhui coefficient, prothrombing, glutamic-pyruvic transaminase etc.Milk thistle honey as the highly finished product of the glucide of milk thistle, have hypotensive, protect the effect such as liver, alleviating pain, be not only delicious nutriment, and the medicine being treatment various diseases, strong health and promoting longevity.Milk thistle honey is also useful especially with the children being easy to the food digested for somagenic need high heat, and it can promote appetite, improves metabolism, people's spirit is good for refreshing and full of physical strength, improves body to the resistance of disease.Milk thistle pollen, as the excellent product of a kind of milk thistle shape, also has suitable effect.Water-soluble propolis can be absorbed better by human body, improves health-care effect.
Turmeric is the rhizome of zingiberaceous plant turmeric, and turmeric is pungent, bitter, and temperature, return spleen, Liver Channel, turmeric can break blood gas, inducing meastruation to relieve menalgia.Turmeric is used for the chest side of body and twinges, amenorrhoea, abdominal mass, rheumatism shoulder arm pain, tumbling and swelling.Further, turmeric has the effects such as reducing blood lipid, antitumor action, anti-inflammatory and cholagogic.
Dandelion composite family herbaceos perennial.Capitulum, the bobbles that on seed, adularescent pappus is formed, new life is bred in the new place that racks after the flowers are in blossom.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, synanthrin in dandelion plant, there are the effects such as diuresis, laxative, removing jaundice subcutaneous ulcer, cholagogic.Dandelion, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Dandelion has abundant carrotene and vC and mineral matter, to the effect that indigestion, constipation are all improved.
Aloe originates in Mediterranean, Africa, is Eremurus chinensis section herbaceos perennial, is to integrate edible, medicinal, improve looks, view and admire plant nova, has the effects such as sterilization, anti-inflammatory, immunity and removing toxic substances.Modern study shows, its leaf containing aloe-emodin, different aloe-emodin and aloe bitter principle etc., pharmacological evaluation have rush down under, antitumaous effect.Chinese aloe flower is cold in nature, bitter and puckery flavor, has heat-clearing, cough-relieving, hemostasia effect, can treat cough, spit blood.
The many growths of Radix Glycyrrhizae, in arid, semiarid desert steppe, desert edge and loess hill area, are also easy to breeding, its strong adaptability, strong stress resistance in the field and flood land of irrigation areas.In China, growth of Glycyrrhiza uralensis is on the ground such as northwest, North, Northeast China.Radix Glycyrrhizae taste is sweet, and property is gentle, enters the heart, spleen, lung, stomach four warp.Raw with cooler, can purging intense heat and detonicating, relieving spasm to stop pain; Process with partially warm, can fall apart exterior cold, tonifying middle-Jiao and Qi.In addition, Radix Glycyrrhizae is also good at being in harmonious proportion the property of medicine, separates the poison of hundred medicines.
Above material not only can eat as health products at ordinary times, also can use as medicinal material, when jointly eating or use, more can mutually promote.Oral disintegrating tablet is as a kind of new formulation, and have and absorb fast, bioavilability is high, and enteron aisle is residual few, and side effect is low and can avoid the remarkable advantage such as first pass effect of liver.Therefore, research and develop and a kind ofly become a urgent and important job containing the compound milk thistle oral disintegrating tablet of above-mentioned material and a kind of preparation method of compound milk thistle oral disintegrating tablet.
Summary of the invention
The first object of the present invention is the weak point overcoming above-mentioned existing background technology, and provides a kind of compound milk thistle oral disintegrating tablet.
The second object of the present invention is the preparation method providing this compound milk thistle oral disintegrating tablet.
The first object of the present invention is reached by following measure: a kind of compound milk thistle oral disintegrating tablet, flies thistle powder, 33 ~ 40 weight portion microcrystalline celluloses, the water-soluble propolis of 1 ~ 5 weight portion, 1 ~ 5 weight portion physiological saline, 0.5 ~ 3 weight portion turmeric, 0.5 ~ 2 weight portion dandelion, 1 ~ 1.5 weight portion aloe, 1 ~ 2 weight portion Radix Glycyrrhizae form by 20 ~ 28 weight portion milk thistle honey, 30 ~ 35 weight parts waters.
Preferably, fly thistle powder by 21 ~ 25 weight portion milk thistle honey, 33 ~ 35 weight parts waters, 33 ~ 35 weight portion microcrystalline celluloses, the water-soluble propolis of 1 ~ 3 weight portion, 1 ~ 3 weight portion physiological saline, 0.5 ~ 2 weight portion turmeric, 0.5 ~ 1.5 weight portion dandelion, 1.2 ~ 1.5 weight portion aloes, 1 ~ 1.5 weight portion Radix Glycyrrhizae form.
Further, the weight ratio of turmeric, dandelion, aloe, Radix Glycyrrhizae is 1:1:1:1.
Further, fly thistle powder by 23 weight portion milk thistle honey, 35 weight parts waters, 34 weight portion microcrystalline celluloses, the water-soluble propolis of 2 weight portion, 3 weight portion physiological saline, 1.5 weight portion turmerics, 1.5 weight portion dandelions, 1.5 weight portion aloes, 1.5 weight portion Radix Glycyrrhizaes form.
The second object of the present invention is reached by following measure: the method preparing above-mentioned compound milk thistle oral disintegrating tablet, comprises the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 12 ~ 18h, obtain mixed material at 25 ~ 35 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 40 ~ 50 DEG C, place 5 ~ 8h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Preferably, step 2) in, at 30 ~ 35 DEG C, place 15h.
Further, step 3) in, at 45 DEG C, place 8h.
The invention has the advantages that:
One, reasonable mixture ratio, has good nutritive value and protects liver effect, especially to convalescent hepatopath, having good rehabilitative action;
Its two, in stable condition, without lamination, mouthfeel is good, and preparation temperature is not high, can ensure that color and luster does not change, for light yellow;
Its three, do not add anticorrisive agent, be a kind of healthy green pure natural product, be of value to the healthy of user.
They are four years old, the present invention sums up in the bee product dietotherapy operation of nearly 20 years, and long-term eating can strengthen body immunity, and has certain opsonic action to hepatopath, because raw material of the present invention is natural prodcuts, except pollen hypersensitivity physique person, edible there is no has any bad reaction to human body for a long time.
The every sheet of compound milk thistle oral disintegrating tablet of the present invention 2 grams.Take as the morning and evening is each once, take before the meal.
Detailed description of the invention
Describe performance of the present invention in detail below in conjunction with embodiment, but they do not form limitation of the invention, only for example.Simultaneously by illustrating that advantage of the present invention will become clearly and easy understand.
A kind of compound milk thistle oral disintegrating tablet, flies thistle powder by 20 ~ 28 weight portion milk thistle honey, 30 ~ 35 weight parts waters, 33 ~ 40 weight portion microcrystalline celluloses, the water-soluble propolis of 1 ~ 5 weight portion, 1 ~ 5 weight portion physiological saline, 0.5 ~ 3 weight portion turmeric, 0.5 ~ 2 weight portion dandelion, 1 ~ 1.5 weight portion aloe, 1 ~ 2 weight portion Radix Glycyrrhizae forms.
Preferably, fly thistle powder by 21 ~ 25 weight portion milk thistle honey, 33 ~ 35 weight parts waters, 33 ~ 35 weight portion microcrystalline celluloses, the water-soluble propolis of 1 ~ 3 weight portion, 1 ~ 3 weight portion physiological saline, 0.5 ~ 2 weight portion turmeric, 0.5 ~ 1.5 weight portion dandelion, 1.2 ~ 1.5 weight portion aloes, 1 ~ 1.5 weight portion Radix Glycyrrhizae form.
Further, the weight ratio of turmeric, dandelion, aloe, Radix Glycyrrhizae is 1:1:1:1.
Further, fly thistle powder by 23 weight portion milk thistle honey, 35 weight parts waters, 34 weight portion microcrystalline celluloses, the water-soluble propolis of 2 weight portion, 3 weight portion physiological saline, 1.5 weight portion turmerics, 1.5 weight portion dandelions, 1.5 weight portion aloes, 1.5 weight portion Radix Glycyrrhizaes form.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 12 ~ 18h, obtain mixed material at 25 ~ 35 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 40 ~ 50 DEG C, place 5 ~ 8h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Preferably, step 2) in, at 30 ~ 35 DEG C, place 15h.
Further, step 3) in, at 45 DEG C, place 8h.
Embodiment 1
Compound milk thistle oral disintegrating tablet, flies thistle powder by 23 weight portion milk thistle honey, 35 weight parts waters, 34 weight portion microcrystalline celluloses, the water-soluble propolis of 2 weight portion, 3 weight portion physiological saline, 1.5 weight portion turmerics, 1.5 weight portion dandelions, 1.5 weight portion aloes, 1.5 weight portion Radix Glycyrrhizaes forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 15h, obtain mixed material at 35 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 45 DEG C, place 8h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Embodiment 2
Compound milk thistle oral disintegrating tablet, flies thistle powder by 28 weight portion milk thistle honey, 30 weight parts waters, 35 weight portion microcrystalline celluloses, the water-soluble propolis of 1 weight portion, 2 weight portion physiological saline, 1.3 weight portion turmerics, 1.3 weight portion dandelions, 1.3 weight portion aloes, 1.3 weight portion Radix Glycyrrhizaes forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 12h, obtain mixed material at 30 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 48 DEG C, place 5h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Embodiment 3
Compound milk thistle oral disintegrating tablet, flies thistle powder by 28 weight portion milk thistle honey, 30 weight parts waters, 35 weight portion microcrystalline celluloses, the water-soluble propolis of 1 weight portion, 2 weight portion physiological saline, 0.5 weight portion turmeric, 2 weight portion dandelions, 1 weight portion aloe, 2 weight portion Radix Glycyrrhizaes forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 12h, obtain mixed material at 30 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 48 DEG C, place 5h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Embodiment 4
Compound milk thistle oral disintegrating tablet, flies thistle powder by 25 weight portion milk thistle honey, 33 weight parts waters, 33 weight portion microcrystalline celluloses, the water-soluble propolis of 3 weight portion, 1 weight portion physiological saline, 3 weight portion turmerics, 0.5 weight portion dandelion, 1.2 weight portion aloes, 1 weight portion Radix Glycyrrhizae forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 18h, obtain mixed material at 33 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 50 DEG C, place 6h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Embodiment 5
Compound milk thistle oral disintegrating tablet, flies thistle powder by 20 weight portion milk thistle honey, 32 weight parts waters, 38 weight portion microcrystalline celluloses, the water-soluble propolis of 5 weight portion, 4 weight portion physiological saline, 2 weight portion turmerics, 1 weight portion dandelion, 1.4 weight portion aloes, 1.2 weight portion Radix Glycyrrhizaes forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 16h, obtain mixed material at 25 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 43 DEG C, place 7h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Embodiment 6
Compound milk thistle oral disintegrating tablet, flies thistle powder by 21 weight portion milk thistle honey, 31 weight parts waters, 40 weight portion microcrystalline celluloses, the water-soluble propolis of 4 weight portion, 5 weight portion physiological saline, 2.5 weight portion turmerics, 1.3 weight portion dandelions, 1.3 weight portion aloes, 1.8 weight portion Radix Glycyrrhizaes forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 14h, obtain mixed material at 28 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 40 DEG C, place 6.5h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Comparative example 1
Contrast compound milk thistle oral disintegrating tablet, flies thistle powder by 23 weight portion milk thistle honey, 35 weight parts waters, 34 weight portion microcrystalline celluloses, the water-soluble propolis of 2 weight portion, 3 weight portion physiological saline, 1.5 weight portion turmerics, 1.5 weight portion dandelions, 1.5 weight portion aloes, 1.5 weight portion Radix Glycyrrhizaes forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) by weight the milk thistle pollen ground, physiological saline, water-soluble propolis are mixed, at 35 DEG C, place 15h, obtain mixed material;
2) the milk thistle honey of weight portion is added step 1) mixed material of gained, mix, at 45 DEG C, place 8h;
3) by step 2) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
4) by weight in step 3) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
5) with tablet press machine by step 4) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
Comparative example 2
Contrast compound milk thistle oral disintegrating tablet, flies thistle powder by 28 weight portion milk thistle honey, 30 weight parts waters, 35 weight portion microcrystalline celluloses, the water-soluble propolis of 1 weight portion, 2 weight portion physiological saline forms.
Prepare the method for above-mentioned compound milk thistle oral disintegrating tablet, comprise the steps:
1) by weight the milk thistle pollen ground, physiological saline, water-soluble propolis are mixed, at 30 DEG C, place 12h, obtain mixed material;
2) the milk thistle honey of weight portion is added step 1) mixed material of gained, mix, at 48 DEG C, place 5h;
3) by step 2) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
4) by weight in step 3) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
5) with tablet press machine by step 4) dehydration after compound milk thistle cream make cylindrical oral disintegrating tablet, obtain compound milk thistle oral disintegrating tablet.
To 500 hepatitis recovery phase patient test, wherein male 282 people, female 218 people, the oldest 65 years old, minimum 27 years old.Take period can not drink, can not maror be eaten, can not greasy food be eaten, must based on light, the hepatitis ill phase is 1 year to 5 years.
Blank is not for take compound milk thistle oral disintegrating tablet Related product, and other respectively take a compound milk thistle oral disintegrating tablet respectively every day sooner or later, and acquired results is as follows:
Table 1 embodiment and comparative example effect
| Hepatitis recurrence rate (%) | Evaluate | |
| Embodiment 1 | 7.6 | Protect liver effect fine |
| Embodiment 2 | 8.3 | Protect liver effect fine |
| Embodiment 3 | 11.9 | Protect liver effective |
| Embodiment 4 | 19.3 | Protect liver effective |
| Embodiment 5 | 16.3 | Protect liver effective |
| Embodiment 6 | 14.7 | Protect liver effective |
| Comparative example 1 | 25.8 | Protect liver effect general |
| Comparative example 2 | 31.3 | Protect liver effect general |
| Blank | 50 | - |
In upper table, hepatitis recurrence rate is that less than 10% to be considered as protecting liver effect fine, and it is effective that hepatitis recurrence rate is considered as protecting liver between 10%-20%, and it is general that hepatitis recurrence rate is considered as protecting liver effect lower than 40%.As can be seen from the above table, the compound milk thistle oral disintegrating tablet of composite crystal added containing turmeric, dandelion, aloe, Radix Glycyrrhizae has and better protects liver effect; And in composite crystal, when the weight ratio of turmeric, dandelion, aloe, Radix Glycyrrhizae is 1:1:1:1, the compound milk thistle oral disintegrating tablet of gained to protect liver effect best.
Other is prior art without the part described in detail.
Claims (7)
1. a compound milk thistle oral disintegrating tablet, is characterized in that: fly thistle powder by 20 ~ 28 weight portion milk thistle honey, 30 ~ 35 weight parts waters, 33 ~ 40 weight portion microcrystalline celluloses, the water-soluble propolis of 1 ~ 5 weight portion, 1 ~ 5 weight portion physiological saline, 0.5 ~ 3 weight portion turmeric, 0.5 ~ 2 weight portion dandelion, 1 ~ 1.5 weight portion aloe, 1 ~ 2 weight portion Radix Glycyrrhizae form.
2. compound milk thistle oral disintegrating tablet according to claim 1, is characterized in that: fly thistle powder by 21 ~ 25 weight portion milk thistle honey, 33 ~ 35 weight parts waters, 33 ~ 35 weight portion microcrystalline celluloses, the water-soluble propolis of 1 ~ 3 weight portion, 1 ~ 3 weight portion physiological saline, 0.5 ~ 2 weight portion turmeric, 0.5 ~ 1.5 weight portion dandelion, 1.2 ~ 1.5 weight portion aloes, 1 ~ 1.5 weight portion Radix Glycyrrhizae form.
3. compound milk thistle oral disintegrating tablet according to claim 1, is characterized in that: the weight ratio of described turmeric, dandelion, aloe, Radix Glycyrrhizae is 1:1:1:1.
4. compound milk thistle oral disintegrating tablet according to claim 1, is characterized in that: fly thistle powder by 23 weight portion milk thistle honey, 35 weight parts waters, 34 weight portion microcrystalline celluloses, the water-soluble propolis of 2 weight portion, 3 weight portion physiological saline, 1.5 weight portion turmerics, 1.5 weight portion dandelions, 1.5 weight portion aloes, 1.5 weight portion Radix Glycyrrhizaes form.
5. prepare the method for the compound milk thistle oral disintegrating tablet in claim 1-4 described in arbitrary claim, it is characterized in that, it comprises the steps:
1) heating in iron pan that turmeric, dandelion, aloe, Radix Glycyrrhizae added water by weight is boiled and is boiled 7 hours one-tenth pastel, and remove slag, be dried into crystalline solid, cooling, obtains composite crystal;
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and step 1) the composite crystal of gained mixes, places 12 ~ 18h, obtain mixed material at 25 ~ 35 DEG C;
3) the milk thistle honey of weight portion is added step 2) mixed material of gained, mix, at 40 ~ 50 DEG C, place 5 ~ 8h;
4) by step 3) mixed material containing milk thistle honey of gained filters, removes particle, obtain compound milk thistle cream;
5) by weight in step 4) add microcrystalline cellulose in the compound milk thistle cream of gained, mix, dehydration;
6) with tablet press machine by step 5) compound milk thistle cream after dehydration makes the cylindrical oral disintegrating tablet of unified specification, obtains compound milk thistle oral disintegrating tablet.
6. the preparation method of compound milk thistle oral disintegrating tablet according to claim 5, is characterized in that: described step 2) in, at 30 ~ 35 DEG C, place 15h.
7. the preparation method of the compound milk thistle oral disintegrating tablet according to claim 5 or 6, is characterized in that: described step 3) in, at 45 DEG C, place 8h.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108175087A (en) * | 2017-12-25 | 2018-06-19 | 广州美耕食品有限公司 | A kind of turmeric milk thistle pollen of Semen Fagopyri Esculenti piece |
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| WO1996025056A1 (en) * | 1995-02-15 | 1996-08-22 | Cazaj Jozef | Process for producing a food product based on bee products, and a food product therefrom |
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| CN101856384A (en) * | 2009-04-09 | 2010-10-13 | 李佳柔 | Liver-protecting combination |
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