CN105388313A - Reagent liquid flow control device for DNA sequencer - Google Patents
Reagent liquid flow control device for DNA sequencer Download PDFInfo
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- CN105388313A CN105388313A CN201510707072.4A CN201510707072A CN105388313A CN 105388313 A CN105388313 A CN 105388313A CN 201510707072 A CN201510707072 A CN 201510707072A CN 105388313 A CN105388313 A CN 105388313A
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- reagent
- base plate
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- Life Sciences & Earth Sciences (AREA)
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- General Physics & Mathematics (AREA)
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- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
Abstract
The invention relates to a reagent liquid flow control device for a DNA sequencer. The reagent liquid flow control device comprises a pump valve integration tube assembly which comprises a pump valve integration base plate, the pump valve integration base plate comprises a peristaltic pump installing plate, a fixing plate connected with the peristaltic pump installing plate and a bottom plate, an opening-shaped box structure is enclosed by all the plates, and a control valve assembly is installed in the middle of a box; the pump valve integration base plate further comprises sucker hole sets formed in the bottom plate and a control valve assembly installing plate arranged in the middle of the bottom plate; correspondingly, the control valve assembly is installed in the middle of the pump valve integration base plate, a hydraulic pump is installed on the side of the pump valve integration base plate, and a liquid road control unit is arranged on the other side of the pump valve integration base plate. According to the reagent liquid flow control device for the DNA sequencer, due to the fact that the pump valve integration tube assembly is adopted, multiple reagents can be simultaneously selected, a sequencing reaction is performed according to a preset sequence, and the testing efficiency is high.
Description
Technical field
The present invention relates to DNA sequencing field, particularly relate to a kind of reagent solution flow control device that can control the DNA sequencer of reactant liquor stream.
Background technology
In DNA sequencing process, chemical reaction occurs sequence testing chip, produce visible ray, the light signal produced by CCD (ChargeCoupleDevice) cameras capture sequencing reaction, can obtain required order-checking information.
Agent delivery system provides plurality of reagents in reaction chip, requires that DNA sequencer can store, carries according to demand, and be convenient for changing reagent; Especially, when selecting different reagent, what special structure and pipeline need be adopted to continue selects to control to different reagent, completes test reaction to be delivered in reaction warehouse in time.
In view of above-mentioned defect, creator of the present invention obtains this creation finally through long research and practice.
Summary of the invention
The object of the present invention is to provide a kind of reagent solution flow control device of DNA sequencer, in order to overcome above-mentioned technological deficiency.
For achieving the above object, the invention provides a kind of reagent solution flow control device of DNA sequencer, comprise pump valve integrated pipe assembly, it comprises pump valve integrated base plate, fixed head, base plate that pump valve integrated base plate comprises peristaltic pump installing plate, is connected with peristaltic pump installing plate, above-mentioned each plate surrounds a ringent body structure; In the centre of this casing, operation valve assembly is installed;
Pump valve integrated base plate also comprises the operation valve unit installing board be arranged in the middle of sipper pore group on base plate and base plate; Accordingly, operation valve assembly is arranged on the center section of pump valve integrated base plate, and hydraulic pump is arranged on the sidepiece of pump valve integrated base plate, arranges fluid path control module in the other side;
Sipper pore group on base plate has been arranged side by side multiple hole, syringe needle suction pipe is through sipper pore, the other end connects Reagent Tube and is connected with the fluid path port of corresponding operation valve, reagent is sucked by the syringe needle suction pipe of downside by valve integrated pipe assembly from the Reagent Tube damping fluid case loading/unloading platform assembly, and pass through the selection of fluid path control module, drived control valve module and hydraulic pump are selected, and are entered by reagent in reagent cartridge, carry out sequencing reaction.
Further, connect an operation valve at the endpiece of the reagent bottle of each reaction reagent, each operation valve is connected successively, and the upper outlet of an operation valve is communicated with the entrance of next operation valve; In use, only need control to open a wherein operation valve, then the reagent solution be communicated with this operation valve is entered in reaction warehouse by pipeline.
Further, described peristaltic pump installing plate is provided with peristaltic pump mounting hole, it is arranged two peristaltic pumps; On base plate, also interval arranges multiple reagent pipe clamp and wire clamp.
Further, described fluid path control module is isolated by a bending plate and fluid path part.
Further, pass into two kinds of reagent in reaction warehouse, one is damping fluid simultaneously, and one is reaction reagent; Wherein, a peristaltic pump drives damping fluid to enter reaction warehouse from damping fluid bottle; Another peristaltic pump drives a kind of reaction reagent of determining and above-mentioned damping fluid mixed flow jointly to enter in reaction warehouse.
Compared with prior art beneficial effect of the present invention is: the reagent solution flow control device of DNA sequencer of the present invention, adopt pump valve integrated pipe assembly, can select plurality of reagents simultaneously, and carry out sequencing reaction according to the order pre-set, testing efficiency is high.
Pump valve assemblies is arranged in the cabinet space of multiple plate composition, is convenient to be arranged on the diverse location of tester; Plate arranges multiple pin hole, different reagent is selected, select accurate, reliable.
Damping fluid case loading/unloading platform assembly, not only can provide the reagent of demand, and handling reagent is convenient, saves cabinet space.
Accompanying drawing explanation
Fig. 1 is the perspective view of liquid case hoistable platform assembly of the present invention;
Fig. 2 is the side-looking structural representation of liquid case hoistable platform assembly of the present invention;
Fig. 3 a is the side-looking structural representation of base of the present invention;
Fig. 3 b is the structural representation of position transducer mount pad of the present invention;
Fig. 3 c is the structural representation of position transducer mount pad of the present invention;
Fig. 3 d is the structural representation of supporting seat of the present invention;
Fig. 3 e is the perspective view of nut mount pad of the present invention;
Fig. 3 f is the perspective view of base of the present invention;
Fig. 4 a is the perspective view of pump valve integrated pipe assembly of the present invention;
Fig. 4 b is the backsight structural representation of pump valve integrated pipe assembly of the present invention;
Fig. 4 c is the plan structure schematic diagram of pump valve integrated pipe assembly of the present invention;
Fig. 4 d is the structural representation of pump valve integrated base plate of the present invention;
Fig. 4 e is the fluid path schematic diagram of liquid-supplying system of the present invention
Fig. 5 a is the perspective view of damping fluid case loading/unloading platform assembly of the present invention;
Fig. 5 b be damping fluid case loading/unloading platform assembly of the present invention face structural representation;
Fig. 5 c is the structural representation in the guide rail cross section of damping fluid case loading/unloading platform assembly of the present invention;
Fig. 5 d is the structural representation of the web joint of damping fluid case loading/unloading platform assembly of the present invention;
Fig. 5 e is the structural representation of the handle plate of damping fluid case loading/unloading platform assembly of the present invention;
Fig. 5 f is the structural representation of slideway of the present invention.
Embodiment
Below in conjunction with accompanying drawing, to above-mentioned being described in more detail with other technical characteristic and advantage of the present invention.
Refer to shown in Fig. 1 and 2, the agent delivery device of the embodiment of the present invention comprises liquid case hoistable platform assembly, its mechanism that pumps driven for motor leading screw, and it is arranged in the right side casing of sequenator.It comprises drive motor 401, be connected with drive motor and the supporting seat 402 of support drive motor, the lead screw assembly be connected with drive motor, be arranged on the reaction liquid case elevating bracket 408 of sidepiece, wherein, damping fluid case loading/unloading platform assembly is equiped with in described reaction liquid case elevating bracket 408, reaction is arranged on the installing plate 404 that is connected with reaction liquid case elevating bracket with liquid case elevating bracket 408, under the driving of screw mechanism, carrying reaction liquid case elevating bracket Reagent Tube group moves up and down.
Reaction comprises the intermediate plate 4081 be connected with installing plate with liquid case elevating bracket 408, be arranged on the supporting plate 4082 of intermediate plate both sides, supporting plate 4082 is provided with horizontal ends, in order to place damping fluid case loading/unloading platform assembly.
The output shaft of described drive motor 401 is connected with leading screw 403, and leading screw is arranged in base 405, and base 405 is connected by supporting seat 402 with the end of drive motor 401; The sidepiece of base 405 is provided with stroke detection switch 406.
The output shaft of described drive motor is connected with the link 4034 of leading screw by shaft coupling 4035; Leading screw is connected with nut 4031, nut is fixed on nut seat 4032; Leading screw lower end is by bearings, and bearing end is provided with bearing (ball) cover 4011.
The liquid case hoistable platform assembly of the embodiment of the present invention by guide rail movement by reagent delivery to assigned address, it is convenient, precisely to control; Pump valve integrated pipe assembly and damping fluid case loading/unloading platform assembly transport by liquid case hoistable platform up and down, complete reagent conveying, course of reaction.
Refer to shown in Fig. 3 a-3f, be also provided with guide rail 407 in the inner side of base, reaction liquid case elevating bracket 408 is arranged on guide rail slide block, with slide block movement; Reaction liquid case elevating bracket 408 is provided with position check-out console 4071, and base is provided with position transducer, and it is arranged on position transducer mount pad 4072.Shown in Fig. 3 b, it is the structural representation of position transducer mount pad of the present invention, and it comprises installing plate 4076, it is arranged and installs threaded hole 4077, be connected by screw with base; Second check-out console 4074, sensor installing plate 4075, arranges slideway 4073 at sensor installing plate 4075 and the second check-out console 4074, passes through, carry out location sensitive with for described position check-out console 4071.
Refer to shown in Fig. 3 c, the position check-out console of the embodiment of the present invention comprises top installing plate 4081, by being arranged on screw in threaded hole 4082 and reaction liquid case elevating bracket 408 is connected and fixed; Also comprise the position detection part 4083 be connected, in order to respond to mutually with position transducer.
Refer to shown in Fig. 3 d, described supporting seat 402 comprises connecting plate for electric motor 4021, and it is connected with motor end face, it is arranged connecting thread hole 4022; The leading screw sleeve 4023 be connected, is provided with locating surface 4024 in leading screw sleeve, in order to install leading screw.
Refer to shown in Fig. 3 e, nut mount pad comprises nut installed surface 4114, it is arranged lead screw hole 4113, and the surrounding of nut installed surface 4114 arranges fastening screw nail; The installed surface 4112 be connected with elevating bracket installing plate 404 is set in upper surface.
Referring to shown in Fig. 3 f, the base 405 of the embodiment of the present invention, is a frame-type structure, leading screw through hole 4051 on upper surface is offered, and lower leading screw through hole 4054 is offered in lower surface, installs bearing supporting wire thick stick in two through hole; Be mounting flange 4053 in base lower end, on the right side of itself and sequenator, the base assembly of casing is connected and fixed; The sidepiece 4052 of base is provided with guide rails assembling face, it offers guide rails assembling threaded hole.
The embodiment of the present invention adopts feed screw nut to carry out reciprocal transportation to reagent, the control accuracy of leading screw, can meet the delivery requirements of reagent.
Refer to Fig. 4 a-4d to show, reagent is sucked by the syringe needle suction pipe 507 of downside by the pump valve integrated pipe assembly of the embodiment of the present invention from the Reagent Tube damping fluid case loading/unloading platform assembly, and pass through the selection of fluid path control module 502, drived control valve module 509 and hydraulic pump 506 are selected, reagent is entered in reagent cartridge, carry out sequencing reaction.
Described pump valve integrated pipe assembly comprises pump valve integrated base plate 508, and pump valve integrated base plate 508 comprises peristaltic pump installing plate 5011, the fixed head 5083 be connected with peristaltic pump installing plate 5011, base plate 5084, and above-mentioned each plate surrounds a ringent body structure; In the centre of this casing, operation valve assembly 509 is installed.
Pump valve integrated base plate 508 also comprises the operation valve unit installing board 5081 be arranged in the middle of sipper pore group 5085 on base plate and base plate; Peristaltic pump installing plate 5011 is provided with peristaltic pump mounting hole 5082, it is arranged two peristaltic pumps 505; On base plate 5084, also interval arranges multiple reagent pipe clamp and wire clamp 5015.
Accordingly, operation valve assembly 509 is arranged on the center section of pump valve integrated base plate 508, and hydraulic pump 506 is arranged on the sidepiece of pump valve integrated base plate 508, arranges fluid path control module 502 in the other side; Fluid path control module 502 is isolated with fluid path part by a bending plate 503.
Pump valve assemblies is arranged in the cabinet space of multiple plate composition, is convenient to be arranged on the diverse location of tester; In embodiments of the present invention, pump valve integrated pipe assembly is arranged on the upper side connecting plate of sequenator casing, and downside is the damping fluid case loading/unloading platform assembly installing Reagent Tube.
In embodiments of the present invention, in order to carry out sequencing reaction to plurality of reagents, the sipper pore group 5085 on base plate has been arranged side by side multiple hole, and syringe needle suction pipe 507 is through sipper pore, and the other end connects Reagent Tube and is connected with the fluid path port of corresponding operation valve; Sipper pore arranges pipe clamp 5013, prevents syringe needle suction pipe from tilting.In use, operation valve controls syringe needle suction pipe 507 and chooses required reagent, is entered in reaction warehouse react by the effect of syringe needle suction pipe 507, operation valve and peristaltic pump.Plate arranges multiple pin hole, different reagent is selected, select accurate, reliable.
The embodiment of the present invention, adopt pump valve integrated pipe assembly, can select plurality of reagents simultaneously, and carry out sequencing reaction according to the order pre-set, testing efficiency is high.
Shown in Fig. 4 e, pass into two kinds of reagent in reaction warehouse, one is damping fluid simultaneously, and one is reaction reagent; Wherein, a peristaltic pump drives damping fluid to enter reaction warehouse from damping fluid bottle; Another peristaltic pump drives a kind of reaction reagent of determining and above-mentioned damping fluid mixed flow jointly to enter in reaction warehouse.
In order to select differential responses reagent, connect an operation valve at the endpiece of the reagent bottle of each reaction reagent, each operation valve is connected successively, and also, the upper outlet of an operation valve is communicated with the entrance of next operation valve.In use, only need control to open a wherein operation valve, then the reagent solution be communicated with this operation valve is entered in reaction warehouse by pipeline.
Refer to shown in Fig. 5 a-5f, damping fluid case loading/unloading platform assembly is the structure of drawing and pulling type, and after platform sets reagent, whole platform assembly is arranged in the casing of right side, and when needs handling reagent, pulled out by platform, after placing, pushed home is put again.
It comprises carrier fluid platform 310, and in the present embodiment, it is one with the arm-tie of handle 3101, and handle is fixed on handle plate 3102; The both sides of carrier fluid platform 310 are provided with web joint 311, and the horizontal part of web joint 311 is connected with the supporting plate 4082 of reaction with liquid case elevating bracket 408; Under the effect of reaction with liquid case elevating bracket 408, carrier fluid platform 310 moves up to syringe needle suction pipe 507 place on the downside of pump valve integrated pipe, through the control of control module, selectively draws reagent.
Between described carrier fluid platform 310 and the web joint 311 of both sides, arrange slide track component 312, it makes carrier fluid platform move along web joint; It comprises the clamp 315 being fixed on web joint 311 sidepiece, move relative to clamp 315 and the slide plate stopped can be coordinated with clamp, slide plate is fixed on the sidepiece of platform web joint 316, and platform web joint 316 is arranged on the lower end of carrier fluid platform, and it drives carrier fluid platform movement.
Refer to shown in Fig. 5 f, clamp 315 is arranged slideway 3105, slide plate can move on slideway 3105; The slip 3105 of clamp 315 arranges stop aperture 3104, when the projection on slide plate is plugged in stop aperture 3104, slide plate and the stop motion of connected carrier fluid platform.
Platform web joint 316 has identical structure with web joint 311, and when mounted, both oppositely install; Its cross section is wedge shape, and comprise the surface level 3112 of a dip plane and sidepiece, surface level 3112 is in order to be connected and fixed.
The damping fluid case loading/unloading platform assembly of the embodiment of the present invention, not only can provide the reagent of demand, and handling reagent is convenient, saves cabinet space.
Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, and this embodiment is also not used to limit the scope of the claims of the present invention, and the equivalence that all the present invention of disengaging do is implemented or changed, and all should be contained in the scope of technical solution of the present invention.
Claims (5)
1. the reagent solution flow control device of a DNA sequencer, it is characterized in that, comprise pump valve integrated pipe assembly, it comprises pump valve integrated base plate, fixed head, base plate that pump valve integrated base plate comprises peristaltic pump installing plate, is connected with peristaltic pump installing plate, above-mentioned each plate surrounds a ringent body structure; In the centre of this casing, operation valve assembly is installed;
Pump valve integrated base plate also comprises the operation valve unit installing board be arranged in the middle of sipper pore group on base plate and base plate; Accordingly, operation valve assembly is arranged on the center section of pump valve integrated base plate, and hydraulic pump is arranged on the sidepiece of pump valve integrated base plate, arranges fluid path control module in the other side;
Sipper pore group on base plate has been arranged side by side multiple hole, syringe needle suction pipe is through sipper pore, the other end connects Reagent Tube and is connected with the fluid path port of corresponding operation valve, reagent is sucked by the syringe needle suction pipe of downside by valve integrated pipe assembly from the Reagent Tube damping fluid case loading/unloading platform assembly, and pass through the selection of fluid path control module, drived control valve module and hydraulic pump are selected, and are entered by reagent in reagent cartridge, carry out sequencing reaction.
2. the reagent solution flow control device of DNA sequencer according to claim 1, it is characterized in that, connect an operation valve at the endpiece of the reagent bottle of each reaction reagent, each operation valve is connected successively, and the upper outlet of an operation valve is communicated with the entrance of next operation valve; In use, only need control to open a wherein operation valve, then the reagent solution be communicated with this operation valve is entered in reaction warehouse by pipeline.
3. the reagent solution flow control device of DNA sequencer according to claim 2, is characterized in that, described peristaltic pump installing plate is provided with peristaltic pump mounting hole, it is arranged two peristaltic pumps; On base plate, also interval arranges multiple reagent pipe clamp and wire clamp.
4. the reagent solution flow control device of DNA sequencer according to claim 3, is characterized in that, described fluid path control module is isolated by a bending plate and fluid path part.
5. the reagent solution flow control device of DNA sequencer according to claim 3, is characterized in that, passes into two kinds of reagent in reaction warehouse simultaneously, and one is damping fluid, and one is reaction reagent; Wherein, a peristaltic pump drives damping fluid to enter reaction warehouse from damping fluid bottle; Another peristaltic pump drives a kind of reaction reagent of determining and above-mentioned damping fluid mixed flow jointly to enter in reaction warehouse.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510707072.4A CN105388313B (en) | 2015-10-27 | 2015-10-27 | A kind of reagent fluid control apparatus of DNA sequencer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510707072.4A CN105388313B (en) | 2015-10-27 | 2015-10-27 | A kind of reagent fluid control apparatus of DNA sequencer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105388313A true CN105388313A (en) | 2016-03-09 |
| CN105388313B CN105388313B (en) | 2017-11-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510707072.4A Expired - Fee Related CN105388313B (en) | 2015-10-27 | 2015-10-27 | A kind of reagent fluid control apparatus of DNA sequencer |
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| CN (1) | CN105388313B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106153962A (en) * | 2016-07-22 | 2016-11-23 | 嘉兴科瑞迪医疗器械有限公司 | A kind of micro-column gel card automatic puncturing device |
| CN108949939A (en) * | 2017-05-26 | 2018-12-07 | 深圳市瀚海基因生物科技有限公司 | The methods, devices and systems controlled are reacted sequencing |
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| CN102707078A (en) * | 2012-05-24 | 2012-10-03 | 中国科学院北京基因组研究所 | Reagent supply system for DNA (deoxyribonucleic acid) sequencer and control method |
| CN103954782A (en) * | 2014-04-11 | 2014-07-30 | 珠海美路得企业发展有限公司 | Biological chip detecting system |
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2015
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Patent Citations (6)
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| US20080254467A1 (en) * | 2007-03-02 | 2008-10-16 | John Frederick Regan | Automated High-Throughput Flow-Through Real-Time Diagnostic System |
| CN201518030U (en) * | 2009-10-14 | 2010-06-30 | 北京吉天仪器有限公司 | Full automatic multi-channel multi-parameter simultaneous measuring flow injection analyzer |
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| CN106153962A (en) * | 2016-07-22 | 2016-11-23 | 嘉兴科瑞迪医疗器械有限公司 | A kind of micro-column gel card automatic puncturing device |
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| CN108949939A (en) * | 2017-05-26 | 2018-12-07 | 深圳市瀚海基因生物科技有限公司 | The methods, devices and systems controlled are reacted sequencing |
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| Publication number | Publication date |
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| CN105388313B (en) | 2017-11-14 |
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