CN105388311B - Full-automatic chemiluminescence immunoassay analysis meter - Google Patents
Full-automatic chemiluminescence immunoassay analysis meter Download PDFInfo
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- CN105388311B CN105388311B CN201510970251.7A CN201510970251A CN105388311B CN 105388311 B CN105388311 B CN 105388311B CN 201510970251 A CN201510970251 A CN 201510970251A CN 105388311 B CN105388311 B CN 105388311B
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- 238000003018 immunoassay Methods 0.000 title claims abstract description 24
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 13
- 238000003860 storage Methods 0.000 claims abstract description 13
- 238000004140 cleaning Methods 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims description 77
- 230000007246 mechanism Effects 0.000 claims description 58
- 238000010276 construction Methods 0.000 claims description 7
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 18
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- 239000002253 acid Substances 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
Abstract
The invention provides Full-automatic chemiluminescence immunoassay analysis meter to include sample storehouse, agent bin, reaction cup storage warehouse, incubation storehouse, cleaning storehouse and detection storehouse.Wherein described sample storehouse includes identity information reading device, and the agent bin includes reagent and mixes conveyer.The Full-automatic chemiluminescence immunoassay analysis meter of the present invention have small volume, clever structure, it is simple and reliable, be easily assembled, the advantages of complete machine operational reliability is high, manufacturing cost is low.
Description
Technical field
The present invention relates to a kind of immunity analysis instrument, more particularly to a kind of full-automatic illumination immunity analysis instrument.
Background technology
Full-automatic detection analysis instrument can be automatically performed a series of from sample-adding, reagent adding, incubation reaction, cleaning, detection etc.
Operating procedure.Determine that the content of certain composition in tested sample has become very universal using full-automatic detection analysis instrument.
Chemiluminescence immune assay (chemiluminescence immunoassay, CLIA), it is by with highly sensitive chemistry hair
Photometric methods are combined with the immune response method of high specific, so as to the various antigens of quantitative detection, haptens, antibody, are swashed
The analytical technology of element, enzyme, aliphatic acid, vitamin and medicine etc..Full-automatic detection analysis instrument being widely used at present
Learn luminescence immunoassay field.Full-automatic chemiluminescence immunoassay analysis meter includes sample storehouse, agent bin, reaction warehouse and detection storehouse etc.
Functional module.The detection process of analyzer generally comprises：Sample and reagent are respectively put into sample storehouse and agent bin first, then
Sample and reagent are added in reaction cup, then make reaction cup by systems such as incubation, cleanings, finally enter reaction cup respectively
Detect storehouse and complete measure.But it is not tight each functional module internal structure to be present in current existing Full-automatic chemiluminescence immunoassay analysis meter
Gather, space-consuming is more, user change reagent and be put into sample tube it is cumbersome the problems such as.
The content of the invention
For the problems of the prior art of solution, the invention provides a kind of automatic chemiluminescence immunoassay
Instrument, including sample storehouse, agent bin, reaction cup storage warehouse, incubation storehouse, cleaning storehouse and detection storehouse, wherein sample storehouse, which include identity, to be believed
Reading device is ceased, agent bin includes reagent and mixes conveyer, the identity information reading device, including information reader, use
In the transmission conveyer frames of several containers, the container base being connected on conveyer frames, the driving for driving container base rotation
Component, the container base include container bare terminal end and drive end, and the drive component includes motor and by motor-driven folder
Gripping member, holder is provided with the conduit coordinated with drive end, when drive end is moved in conduit and is stopped, holder driving
The drive end rotation；The identity information reading device also includes being used to adjust driving extreme direction to promote drive end to enter conduit
Guide.
Further, the holder is arranged in the transmitting path of drive end.Further, the maximum of the drive end
Size is more than the width of conduit, and the minimum dimension of drive end is less than the width of conduit.Further, the guide is arranged on drive
The side of moved end transmitting path, gap is provided between guide and drive end.Further, the guide includes the first guiding
Plate, the first guide plate are arranged on the inboard side of drive end transmitting path.Further, first guide plate is arranged on conduit
Porch.Further, first guide plate is distributed in the whole transmitting path of drive end, towards drive on the first guide plate
Moved end side is provided with the first breach, and the clamp parts are contained in the first breach, and holder is with drive end in the first breach
Middle rotation.
Further, reagent, which mixes conveyer, includes drive device, transporter and tumbler, and transporter includes fortune
Send the conveyer of kit and mix the mixing mechanism of reagent, drive device driving conveyer produces relative with mixing mechanism
Motion, it is driven and coordinates between tumbler and mixing mechanism, the conveyer and mixing mechanism, which mutually connect together, forms axle
Bearing structure.Further, conveyer and mixing mechanism are circular ring structure, and conveyer is arranged at the centre bore of mixing mechanism
Interior, drive device includes motor and drive division, and drive division is arranged in the centre bore of conveyer.Further, transport
Mechanism is inner gear structure, and mixing mechanism is external tooth wheel construction, and driving rack, the driving rack and fortune are provided with drive division
The internal gear of mechanism is sent to be intermeshed, the tumbler is gear, and the external gear of the tumbler gear and mixing mechanism is mutual
Engagement.
Full-automatic chemiluminescence immunoassay analysis meter small volume of the present invention, clever structure, it is simple and reliable, be easily assembled,
Complete machine operational reliability is high, and manufacturing cost is low.
Brief description of the drawings
Fig. 1 is the axle geodesic structure schematic diagram of the present invention.
Fig. 1-1 is the mplifying structure schematic diagram at A in Fig. 1.
Fig. 2 is Fig. 1 main structure diagram.
Fig. 3 is the axle geodesic structure schematic diagram of another state of the present invention.
Fig. 3-1 is the mplifying structure schematic diagram at B in Fig. 3.
Fig. 4 is Fig. 3 main structure diagram.
Fig. 5 is the axle geodesic structure schematic diagram of drive component in the present invention.
Fig. 5-1 is Fig. 5 main structure diagram.
Fig. 5-2 is Fig. 5 overlooking the structure diagram.
Fig. 6 is the axle geodesic structure schematic diagram of container base in the present invention.
Fig. 6-1 is Fig. 6 left view structural representation.
Fig. 6-2 is Fig. 6 main structure diagram.
Fig. 6-3 is the structural representation of container base another embodiment in the present invention.
Fig. 6-4 is the main structure diagram of container base another embodiment in the present invention.
Fig. 7 is the axle geodesic structure schematic diagram that drive component coordinates with guide in the present invention.
Fig. 8 is the structural representation that drive component in the present invention, guide and drive end coordinate.
Fig. 9 is another structural representation that drive component in the present invention, guide and drive end coordinate.
Figure 10 is the yet another construction schematic diagram that drive component in the present invention, guide and drive end coordinate.
Figure 10-1 is a kind of mated condition schematic diagram of guide and drive end in the present invention.
Figure 10-2 is another mated condition schematic diagram of guide and drive end in the present invention.
Figure 10-3 is another of guide and drive end mated condition schematic diagram in the present invention.
Figure 11 kits box body and the schematic diagram of reagent bottle separation.
Figure 12 kit box bodies schematic diagram together with reagent bottle combination.
Figure 13 reagent storages device mixes the schematic diagram of conveyer cooperation with reagent.
Figure 14 reagents mix conveyer schematic diagram.
Figure 15 reagents mix conveyer schematic diagram.
Figure 16 agent bin top views.
Figure 17 is the agent bin sectional view in Figure 16 A-A directions.
Figure 18 is put into the agent bin schematic diagram of kit.
Figure 19 carries the agent bin schematic diagram of refrigerating plant.
The internal structure schematic diagram of Figure 20 Full-automatic chemiluminescence immunoassay analysis meters.
Figure 21 Full-automatic chemiluminescence immunoassay analysis meter schematic diagrames.
Figure 22 removes the Full-automatic chemiluminescence immunoassay analysis meter of sample storehouse side shield.
Embodiment
A kind of Full-automatic chemiluminescence immunoassay analysis meter 9000, sample storehouse 9300, agent bin are included as shown in Figure 20 to 22
9400th, reaction cup storage warehouse 9500, incubation storehouse 9600, cleaning storehouse 9700 and detection storehouse 9800.Sample to be tested carries out constituent analysis
When, sample and reagent are first respectively put into sample storehouse and agent bin, Full-automatic chemiluminescence immunoassay analysis meter stores from reaction cup
Reaction cup is taken out in storehouse 9500, and puts it into and is incubated in storehouse.Then sample and reagent are added to reaction by predetermined program
In cup, start and be incubated program, cleaning procedure, reaction cup is entered detection storehouse and complete sample component analysis.It is wherein described
Sample storehouse includes identity information reading device, and the agent bin includes reagent and mixes conveyer.
Wherein identity information reading device, as Figure 1-4, including several are provided with the container 2 of identity information, information is read
Take device 4 and container rotating device.When container rotating device drives container spinning, by information reader 4 during container rotation
The identity information on container 2 is read to identify the container.Information reader 4 and container rotating device control by controller, control
Device control container rotating device processed transmits to container 2, and completes the rotation of container 2, while control information in ad-hoc location
Reader 4 reads the identity information on container 2 and storage.Preferably, the identity information is carried by bar code, RF tag, figure
Body or colour carrier embody.Wherein, bar code can be the information identifiers such as one-dimensional bar code, Quick Response Code.Preferably, the container
2 be test tube, reagent bottle or beverage bottle.
A kind of container rotating device, as shown in Fig. 1,1-1,2,3,3-1 and 4, including for transmitting the biography of several containers 2
Send frame 6, the container base being connected on conveyer frames 68 and the drive component 10 for driving the rotation of container base 8, container base 8
Including container bare terminal end 802 and drive end 804, drive component 10 includes motor 102 and by motor-driven holder 104, folder
Gripping member 104 is provided with the conduit 106 coordinated with drive end 804, when drive end 804 is moved in conduit 106 and is stopped, the folder
Gripping member 104 drives the drive end 804 to rotate.Bare terminal end 802 is used for holding vessels, and holding container 2 is firm to be connected to container bottom
In seat 8, drive end 804 is used to drive bare terminal end 802 to rotate under the cooperation of drive component 10.Holder 104 is straight by motor 102
Driving is connect, as holder 104 is connected directly between on 102 output shaft of motor, or holder 104 is driven indirectly by motor 102,
As holder 104 is connected by rotating shaft or bearing with motor.Preferably, conveyer frames 6 are curved, annular or linear.Fig. 1-4
In by conveyer frames 6 be annular exemplified by be described in detail.
Wherein, the motion of conveyer frames 6 and drive component 10 is controlled by controller, under the control of the controller, by conveyer frames 6
Container base 8 is transmitted one by one, and when container base 8 moves to the position of holder 104, i.e., drive end 804 moves to conduit 106
In, controller control conveyer frames 6 stop, and drive end 804 is rested in conduit 106, and controlled motor 102 drives holder
104 rotations, 8 rotations of container bottom are driven by holder 104.Reference picture 3,3-1 and 4, drive end 804 are moved in transmitting path
On, close to the porch of conduit 106 and conduit 106 is introduced into, now, conveyer frames 6 continue to move, when drive end 804 enters
When in conduit 106, the stop motion of conveyer frames 6, drive end 804 is rested in conduit 106, reference picture 1,1-1 and 2, is now controlled
Motor 102 drives holder 104 to rotate.Container rotating device when rotated, the conduit 106 on holder 104 is arranged to drive
A part in the transmitting path of moved end 804, i.e. conduit 106 must be through on path, simple in construction, cost be low drive end 804.Folder
Gripping member 104 and the structure of drive end 804 need the mutual cooperation between holder 104 and drive end 804 without especially fine,
Holder 104 forms conduit 106 and can offseted when rotated with drive end 804, it is possible to completes the function of rotation, trickle mill
Damage etc. impacts all without the stability to rotating device and effect.
Preferably, reference picture 1-4, the holder 104 is arranged on the biography of drive end 804 to one kind as container rotating device
Send on path.The transmitting path of drive end 804 is determined by the shape of conveyer frames 6, if conveyer frames are annular, the biography of drive end
It is also annular to send path, by that analogy.Holder 104 is directly installed in the transmitting path of drive end 804, i.e. conduit 106
Position be arranged in the transmitting path of drive end 804, be easy to drive end 804 to move in holder 104, it is simple in construction, when
So, holder 104 can also be such that holder 104 moves in the transmitting path of drive end by other Component drivers, such as rise or
Translation etc., also can be achieved on the purpose of the present invention.
Preferably, reference picture 5,5-1 and 5-2, the holder 104 include bottom plate 112 to one kind as container rotating device
And the first double wall 108 and the second double wall 110 of the both ends of the surface of bottom plate 112 are distributed in, between the first double wall 108 and the second double wall 110
Passage be conduit 106.The structure of conduit 106 can be arranged as required to, and conduit 106 needs to coordinate with drive end so that drives
Moved end can be moved in conduit along transmitting path, and drive end rotation can be driven by holder.As further preferred, folder
Gripping member 104 is in cylindrical shape, and conduit 106 is arranged on the top of cylinder.As further preferred, the porch of conduit 106
Opened wide with exit opposite intermediate portions.Facilitate drive end to enter, guiding can be played a part of.
Preferably, the full-size of the drive end 804 is more than the width of conduit 106 to one kind as container rotating device,
The minimum dimension of drive end 804 is less than the width of conduit 106.The full-size of drive end 804 is the maximum of drive end cross section
Size, minimum dimension refer to the minimum dimension of drive end cross section.So that drive end is cuboid as an example, pair of cuboid cross section
Linea angulata is full-size, a width of minimum dimension of cross section, if drive end is irregular shape, takes drive end 804 maximum horizontal
The full-size and minimum dimension in section.The minimum dimension of drive end 804 is less than the width of conduit 106, makes drive end 804 can be with
Moved to along transmitting path in conduit 106, otherwise, drive end 804, which can be clamped part, to be stopped and do not enter in conduit 106, is driven
The full-size of moved end 804 is more than the width of conduit 106, when holder rotates, drive end is offseted with holder, being capable of band
Dynamic drive end rotation, the empty rotation of holder is avoided, and can not be offseted with drive end.
Preferably, reference picture 6,6-1 and 6-2, the drive end 804 are a block to one kind as container rotating device, gear
Block is in rectangular-shape.The shape of drive end 804 can be arranged as required to, and can be coordinated with the conduit 106 of holder 104, be made
Obtaining drive end 804 can move in conduit 106 along transmitting path, and by holder 104 drive end 804 can be driven to rotate.Ginseng
According to Fig. 6-3 and 6-4, as a kind of embodiment, drive end 804 is a block, and block is in rectangular-shape, is set in the bottom of block
There are two cuboid projections 814, realize during container rotation, it is necessary to which the conduit on holder is engaged with the drive end.Preferably,
Two relative sides of the drive end 804 are smooth curved surface.Two opposite flanks refer to that drive end enters entering for conduit 106
Enter the another side in face and the relative face, smooth curved surface makes drive end 804 be easier to enter in conduit 106, is entering fashionable may be used also
To play guide effect.The one side that drive end 804 is connected with container base 8 is top surface, and drive end 804 is provided with a spigot surface,
Spigot surface is used to coordinate with guide, drive end is kept certain direction.Preferably, the bare terminal end 802 is one end open
Hollow o cylindrical body.Preferably, the inner surface of the body bottom portion is hemispherical curved surface.Preferably, the body bottom portion
Provided with through hole.
One kind as container rotating device is preferred, reference picture 6,6-1 and 6-2, between bare terminal end 802 and drive end 804
Provided with the guide rail 806 for being arranged on container base 8 on conveyer frames.Preferably, the guide rail 806 includes first annular flange
808 and second annular flange 810, the first annular axially spaced-apart of 808 and second annular flange of flange 810 distribution it is first annular convex
The annular groove 812 that the annular flange 810 of edge 808 and second is formed.Reference picture 6-4, during installation, the part of conveyer frames 6 extends to ring
In connected in star 812, the first annular annular flange 810 of flange 808 and second is separately positioned on the both sides up and down of conveyer frames 6, and with
Conveyer frames 6 offset, and avoid container base 8 from being separated from conveyer frames 6.Guide rail 806 and conveyer frames 6 leave gap between installing, between being somebody's turn to do
Gap is used to realize rotation of the container base with respect to conveyer frames, to reduce resistance between the two.Preferably, the drive end 804
Upper top surface be fixedly connected with guide rail 806 or drive end 804 is integrally formed with guide rail 806.
Preferably, reference picture 7-8, the rotating device also includes being used to adjust drive end 804 one kind as rotating device
Direction promotes drive end 806 into the guide of conduit 106.Guide adjusts the direction of drive end so that the vertical profile of drive end
Face is in predetermined angle with guide.The one side of drive end 804 towards guide is spigot surface, the vertical section of drive end and guiding
Face is parallel, if shape of the guide for rule, predetermined angle is measured with the face where guide side wall, if guide is not advise
Then shape, then predetermined angle is measured to the tangent line of the most short point of guide side wall distance with drive end vertical section.Predetermined angle is used
It can smoothly enter conduit 106 in guarantee drive end 804, stop without being clamped part 104, also allow drive end 804 leading
To under the guiding of part, rotation that can be in the angle by a small margin, the rotation more than the predetermined angle can be prevented by guide.
Preferably, the guide is arranged on the side of the transmitting path of drive end 804 to one kind as guide, guide with
Gap is provided between drive end.Drive end 804 coordinates with guide gap when being moved along transmitting path, guide and drive end it
Between gap drive end can be moved with counter-guide, reduce frictional resistance between the two.
Preferably, reference picture 7-8, the guide includes the first guide plate 12, the first guide plate to one kind as guide
12 are arranged on the inboard side of the transmitting path of drive end 804.The inboard side of transmitting path is generally the position at approaching device center, and
The outer side edges of transmitting path are generally the position away from device center, if conveyer frames 6 are annular, annular is close to circle centre position
For inboard side.First guide plate 12 has a side wall 1202, and the side wall 1202 is relative with the spigot surface of drive end 804, both it
Between gap coordinate.
Preferably, reference picture 8, first guide plate 12 is distributed in the whole biography of drive end to one kind as the first guide plate
Send on path, the first breach 1204 is provided with towards drive end side on the first guide plate, the holder 104 is partially received in
In one breach 1204, holder 104 rotates with drive end 804 in the first breach 1204.The shape of first guide plate 12 follows
The shape of drive end transmitting path, here so that conveyer frames are annular as an example, the first breach 1204 is on the first guide plate 12
Depressed part, drive end 804 can rotate in the first breach 1204.Preferably, first guide plate 12 is curved, annular
Or linear.
Preferably, reference picture 9, the guide also include the second guide plate 14 being distributed side by side with the first guide plate 12,
Second guide plate 14 is arranged on another side of the transmitting path of drive end 804, towards the first breach 1204 on the second guide plate 14
Side be provided with the second breach 1402, the holder 104 is contained in the port that two breach are formed, and holder 104 is with driving
Moved end 804 rotates in port.That is the transmission path at intervals of drive end 804 that the first guide plate 12 and the second guide plate 14 are formed
Footpath, drive end 804 transmit in the interval of the first guide plate 12 and the second guide plate 14.First breach 1204 and the second breach
1402 can not also set, and the guide plate at the first breach 1204 and the second breach 1402, which directly disconnects, also may be used.Preferably, described first
Breach 1204 is in arc-shaped.Second breach 1402 is also in arc-shaped, facilitates the entrance of drive end 804.Preferably, described first lead
Several mounting holes are provided with to plate 12, some support columns 1206 are connected with mounting hole.
Preferably, reference picture 10, first guide plate 12 is arranged on the entrance of conduit 106 to one kind as the first guide plate
Place.First guide plate 12 is a bit of in transmitting path, and it can be arcuation or strip that the first guide plate 12 is overall.Work as drive end
804 when moving near the first guide plate 12, due to the stop of the first guide plate 12, carries out position adjustment to drive end 804, makes
The vertical section of drive end is in predetermined angle with guide.When drive end 804 is moved near the first guide plate 12, drive end
The angle of the direction in 804 vertical sections and the first guide plate 12 is probably 0 degree, acute angle, right angle or obtuse angle, and various angles are by first
Guide plate 12 is adjusted to predetermined angle.As shown in Figure 10-1,10-2 and 10-3, when angle is acute angle, right angle or obtuse angle, first
The upper end of guide plate 12 and drive end 804 offsets, the upper end stress of drive end 804, is rotated between drive end up time, and drive end enters
The region of first guide plate 12；When angle is 0 degree, drive end 804 is directly entered the region of the first guide plate 12.It is preferred that
Ground, the first guide plate 12 are domatic provided with one away from the one end of conduit 106.It is domatic to be used to enter where the first guide plate 12 to drive end
Region provides guiding.Preferably, first guide plate 12 extends to conduit 106 by the porch of conduit 106
Exit.Do not set the first guide plate 12 at holder 104, be easy to rotation of the drive end 804 in clip position.
A kind of container comprises the following steps from shifting method：
A) a kind of container spin rotary device is provided, the container spin rotary device includes being used to transmit several containers 2
Conveyer frames 6, the container base 8 being connected on conveyer frames 6 and the drive component 10 for driving the rotation of container base 8, container bottom
Seat 8 includes container bare terminal end 802 and drive end 804, drive component 10 including motor 102 and by motor-driven holder 104,
Holder 104 is provided with the conduit 106 coordinated with drive end 804, should when drive end 804 is moved in conduit 106 and is stopped
Holder 104 drives the drive end 804 to rotate；
B) holder 104 is rested in the transmitting path of drive end 804, keeping the position of holder 104 makes drive end
804 can enter conduit 106；
C) control conveyer frames 6 start to transmit container 2, when drive end 804 is moved in the conduit 106 of holder 104, control
Conveyer frames 6 processed stop transmission, drive end 804 is stopped in the channel；As shown in Figure 1-2；
D) motor 102 drives holder 104 to rotate, and holder 104 and drive end 804 offset cooperation, and holder 104 drives
The rotation of drive end 804, so as to drive the rotation of container base 8；
E) motor 102 controls holder 104 to stop the rotation, and keeps the position of holder 104 to make drive end 804 can during stopping
To leave conduit 106 along transmitting path；
F) repeat step c-e.
By said vesse from shifting method, it is possible to achieve container transmits one by one, one by one rotation.Wherein, the appearance in step a)
Device spin rotary device includes the combination of various technical schemes is mentioned above.
As shown in FIG. 11 and 12, box body 92 and mixing chamber 93 are included for depositing the kit 91 of detection reagent, it is described
The reagent for needing to mix when chamber 93 is used to deposit detection is mixed, the reagent can be directly loadable into the mixing intracavitary, or dress in advance
Placed into after entering reagent bottle 911 or 95 in mixing chamber 93.If desired, kit can also include storage chamber 94, the storage
To mixing the reagent for requiring less high when chamber 94 is used to deposit detection, the reagent can be directly loadable into the storage chamber, or in advance
Placed into after being initially charged with reagent bottle in storage chamber 94.
In one embodiment, include fastener 913 on the reagent bottle 911, include on the storage chamber 94 block piece and
Fastener passage 912.Block piece is used to stop that fastener leaves storage chamber.When block piece stops fastener, lift the same of reagent bottle
When, it is possible to kit box body is lifted together.The balance of whole box body is kept, and is unlikely to tilt, reagent occurs and inclines
The danger poured out.In one embodiment, the block piece is the lid eaves 914 of lid 98 on box body.
In the embodiment shown in fig. 11, the reagent that need to be mixed, which is previously charged into, to be mixed in reagent bottle 95, the mixing reagent bottle
Tumbler 96 is provided with 95.Mixing reagent bottle 95 equipped with reagent is put into the mixing chamber 93 of kit, and tumbler 96 rotates
When driven mixing reagent bottle 95 to rotate mixing in chamber 92, make reagent in reagent bottle 95 because rotation is mixed in suspending
Even state.Tumbler 96 can mix the structure that reagent bottle 95 carries, i.e., be put into mixing chamber in reagent bottle 95 as shown in figure 11
Before, tumbler 96 is inherently already installed on reagent bottle 95.Tumbler 96 can also be a single part, be tried when mixing
After agent bottle 95 is put into mixing chamber 93, mixes reagent bottle and coordinate with tumbler, so as to which reagent bottle 95 and tumbler 96 are assembled in into one
Rise.When tumbler is as separate part, it may be mounted on kit, or with being arranged on the matching used instrument of kit
On.In the embodiment shown in fig. 12, after reagent bottle 95 is put into mixing chamber 93, tumbler 96 is at the breach 931 for mixing chamber 93.
Reagent, which mixes conveyer, includes transporter and drive device, and transporter includes conveyer 9201 and mixed
Mechanism 9202, conveyer 9201 and mixing mechanism 9202, which mutually connect together, forms bearing arrangement.Conveyer is used to put
Kit is put, and kit is sent to the relevant position of analyzer.Mixing mechanism 9202 coordinates with tumbler 96, for mixing
The reagent that needs in kit mix.Drive device includes drive division 9301 and power part 9302.Drive device driving is transported
Mechanism 9201 produces relative motion with mixing mechanism, is used between tumbler 96 and mixing mechanism 9202 that reagent mixes and produces
Transmission, so as to realize the transhipment of detection reagent and mixing.
In embodiment as shown in Figure 13 to 17, conveyer 9201 and mixing mechanism 9202 are circular ring structure, transveyer
Structure is arranged in the centre bore of mixing mechanism, and both are assembled to each other as a bearing arrangement.In reality as shown in figure 15
Apply in example, ball 9203 is provided between conveyer 9201 and mixing mechanism 9202.Mixing mechanism is fixedly mounted on analyzer
On.The drive division 9301 of drive device is arranged in the centre bore of conveyer.In one embodiment, conveyer 9201 is
Inner gear structure, mixing mechanism 9202 are external tooth wheel construction, are provided with driving rack on drive division 9301, the driving rack with
The internal gear engagement of conveyer, power part 9302 is motor.Kit as shown in Figure 2, which mixes intracavitary and carried including bottom, to be turned
The mixing reagent bottle 95 of moving part 96, the magnetic particle reagent of the built-in mixing in need of reagent bottle, the tumbler 96 are gear structure.
When kit 91 is positioned on conveyer 9201, the gear (tumbler) and mixing mechanism 9202 of reagent bottle bottom are installed on
External gear is intermeshed.Opening motor rotates drive division, drive division driving conveyer rotation, is placed on conveyer
Kit also rotates together therewith, the external gear of gear and mixing mechanism is produced transmission.Bottom carries the reagent bottle of tumbler
Rotation occurs under mixing mechanism and tumbler engaged transmission, the reagent in reagent bottle is mixed because of rotation.At this
In embodiment, mixing mechanism is fixedly mounted on analyzer, and mixing mechanism can not rotate, and conveyer is surrounded in mixing mechanism
Mandrel rotates.In another scheme, conveyer and mixing mechanism can also rotate against around same central shaft.At another
In embodiment, the kit 91 can be first placed in kit bracket 9100, and the kit bracket is arranged on transveyer
On structure.
The kind of drive between the drive division 9301 and conveyer 9201 is also selected from meshed transmission gear, friction
The modes such as transmission, pulley drive.The kind of drive between mixing mechanism 9202 and tumbler 96 can also engage from gear to be passed
The modes such as dynamic, frictional drive.
Conveyer and mixing mechanism are fitted together in the form of bearing arrangement, conveyer and mixing machine can be reduced
Coefficient of friction of the structure in motion process, lower mechanical noise during machine operation, reduce the energy consumption of analyzer operation, extension point
The service life of analyzer.Compared to needing that conveyer and mixing mechanism are installed into analysis step by step respectively in the prior art
Instrument, conveyer and mixing mechanism of the present invention can be as an integral installations in analyzer, and this make it that installation operation is simple
Singly, conveniently, be advantageous to regularly maintain, clean, change.And both conveyer and mixing mechanism level can be effectively ensured
Face keeps mutual parastate, so that it is guaranteed that both position relationships are stable, keeps higher dynamic equilibrium state, improves analysis
The running precision of instrument.In long-term running so that the cooperation of tumbler and mixing machine component is stable, it is not easy to which generation is beaten
The phenomenon of tooth.Conveyer and mixing mechanism are assembled into bearing arrangement, and corresponding assembly parts will be reduced on analyzer, so as to save
The about installing space of analyzer parts.Drive division is arranged in conveyer centre bore, make use of the spare time of analyzer well
Between being empty so that the overall volume of analyzer becomes smaller.
In another embodiment, mixing mechanism 9202 is arranged in the centre bore of conveyer 9201, and both mutually assemble
Turn into bearing arrangement together.Conveyer 9201 is external tooth wheel construction, and mixing mechanism 9202 is inner gear structure, and drive division is set
Put the outer side edges in conveyer.
In one embodiment, conveyer includes pedestal and mounting seat, and pedestal is located in the centre bore of mixing mechanism, and
Interconnected with mixing mechanism in a manner of bearing, mounting seat is arranged on the pedestal, and mounting seat, which is used to place, to be tried
Agent box.Include the driving member coordinated with drive division in mounting seat.Drive division drive installation seat rotates, and mounting seat drives transveyer
Structure rotates relative to mixing mechanism, and the kit being placed in mounting seat also rotates together therewith, tumbler is produced with mixing mechanism
Raw transmission.Under mixing mechanism and tumbler transmission rotation occurs for reagent bottle of the bottom with tumbler, makes to be mounted in reagent bottle
Interior reagent mixes because of rotation.In another embodiment, conveyer does not include the driving member coordinated with drive division, mixes
Do not include the driving member coordinated with tumbler in even mechanism, conveyer and mixing mechanism are assembled to each other as bearing knot
Structure.Described driving member, such as gear, brake pad, the part independent as one, are separately mounted to conveyer and mixing machine
The relevant position of structure.
The agent bin 9400 of Full-automatic chemiluminescence immunoassay analysis meter includes reagent storage device and examination as depicted in figs. 18-19
Agent mixes conveyer.The reagent, which mixes conveyer, includes transporter and drive device, and transporter includes transveyer
Structure 9201 and mixing mechanism 9202, conveyer 9201 and mixing mechanism 9202, which mutually connect together, forms bearing arrangement.Examination
Agent storing unit includes kit and kit bracket, and the kit bracket 9100 is arranged on the conveyer 9201,
Kit 91 is put into kit bracket 9100.The tumbler 96 and mixing mechanism being connected with equipped with the reagent bottle for mixing reagent
9202 driving member cooperates.Drive device includes drive division 9301 and power part 9302.Conveyer fortune is mixed in reagent
During row, drive device driving conveyer 9201 produces relative motion with mixing mechanism, and it is corresponding that kit is transported into detection
Position.Simultaneously with the rotation of conveyer, transmission, reagent are produced between the tumbler and mixing mechanism that are mixed for reagent
Under mixing mechanism and tumbler transmission rotation occurs in kit for bottle, the reagent in the reagent bottle is mixed because of rotation
It is even.Agent bin 9400 also includes heat-insulation layer 9401, Cang Gai, agent bin refrigerating plant 9403 and reagent bottle null pick-up 9404.
The reagent of Full-automatic chemiluminescence immunoassay analysis meter mixes method, is first put into the kit equipped with detection reagent
Agent bin, and be positioned on kit bracket of the present invention.The kit bracket mixes with reagent of the present invention
Conveyer cooperates.When reagent mixes conveyer operation, the drive device driving conveyer of fully-automatic analyzer
9201 produce relative motion with mixing mechanism, and are transported to corresponding kit according to the needs of detection project, conveyer
The reagent collection position of analyzer.Simultaneously with the rotation of conveyer, between the tumbler and mixing mechanism for reagent mixing
Transmission is produced, reagent bottle occurs rotation under mixing mechanism and tumbler transmission in kit, made in the reagent bottle
Reagent mixes because of rotation.
Claims (7)
1. Full-automatic chemiluminescence immunoassay analysis meter, including sample storehouse, agent bin, reaction cup storage warehouse, be incubated storehouse, cleaning storehouse and
Storehouse is detected, wherein sample storehouse includes identity information reading device, and agent bin includes reagent and mixes conveyer, it is characterised in that
The identity information reading device, including information reader, the conveyer frames for transmitting several containers, it is connected to conveyer frames
Container base, the drive component for driving container base rotation, the container base includes container bare terminal end and drive end,
The drive component includes motor and is provided with the conduit coordinated with drive end by motor-driven holder, holder, is worked as drive
When moved end moves in conduit and stopped, the holder drives the drive end rotation；The identity information reading device also wraps
The guide for promoting drive end to enter conduit for adjusting driving extreme direction is included, the guide is arranged on drive end transmitting path
Side, gap is provided between guide and drive end, the guide includes the first guide plate, and the first guide plate is arranged on drive
The inboard side of moved end transmitting path, first guide plate is distributed in the whole transmitting path of drive end, on the first guide plate
The first breach is provided with towards drive end side, the clamp parts are contained in the first breach, and holder and drive end are the
Rotated in one breach.
2. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that the holder is arranged on
In the transmitting path of drive end.
3. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that the maximum of the drive end
Size is more than the width of conduit, and the minimum dimension of drive end is less than the width of conduit.
4. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that first guide plate is set
Put in the porch of conduit.
5. Full-automatic chemiluminescence immunoassay analysis meter according to claim 1, it is characterised in that reagent mixes conveyer
Including drive device, transporter and tumbler, transporter includes the conveyer for transporting kit and mixes the mixed of reagent
Even mechanism, drive device driving conveyer produce relative motion with mixing mechanism, are driven and match somebody with somebody between tumbler and mixing mechanism
Close, the conveyer and mixing mechanism, which mutually connect together, forms bearing arrangement.
6. Full-automatic chemiluminescence immunoassay analysis meter according to claim 5, it is characterised in that conveyer and mixing machine
Structure is circular ring structure, and conveyer is arranged in the centre bore of mixing mechanism, and drive device includes motor and drive division, is driven
Dynamic portion is arranged in the centre bore of conveyer.
7. Full-automatic chemiluminescence immunoassay analysis meter according to claim 6, it is characterised in that conveyer is internal gear
Structure, mixing mechanism are external tooth wheel construction, and driving rack, the internal tooth of the driving rack and conveyer are provided with drive division
Wheel intermeshing, the tumbler is gear, the external gear intermeshing of the tumbler gear and mixing mechanism.
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| CN106824560A (en) * | 2017-03-14 | 2017-06-13 | 骏实生物科技(上海)有限公司 | A kind of automatic mixing device for centrifugal platform |
| CN108562757A (en) * | 2018-04-13 | 2018-09-21 | 霍邱县康乾商贸有限公司 | A kind of chemiluminescence immune assay device |
| CN108732164B (en) * | 2018-08-07 | 2023-09-29 | 广州万孚生物技术股份有限公司 | Full-automatic chemiluminescence immunoassay instrument |
| CN109030809B (en) * | 2018-10-31 | 2021-08-20 | 蓝怡科技集团股份有限公司 | Allergen IgE antibody automatic analyzer |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN203170251U (en) * | 2013-04-16 | 2013-09-04 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent bottle |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN103675305A (en) * | 2012-09-21 | 2014-03-26 | 蓝伊精机株式会社 | Specimen transport apparatus, specimen processing apparatus, and specimen transport method |
| CN205280740U (en) * | 2015-12-21 | 2016-06-01 | 艾康生物技术(杭州)有限公司 | Chemical illumination immunity analysis instrument |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07260794A (en) * | 1994-03-23 | 1995-10-13 | Omron Corp | Stirring mechanism of sample preparation device |
| JP4653771B2 (en) * | 2007-03-15 | 2011-03-16 | ベックマン コールター， インコーポレイテッド | Reagent container transport device |
-
2015
- 2015-12-21 CN CN201510970251.7A patent/CN105388311B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103675305A (en) * | 2012-09-21 | 2014-03-26 | 蓝伊精机株式会社 | Specimen transport apparatus, specimen processing apparatus, and specimen transport method |
| CN203170251U (en) * | 2013-04-16 | 2013-09-04 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent bottle |
| CN103592450A (en) * | 2013-11-28 | 2014-02-19 | 博奥赛斯（天津）生物科技有限公司 | Full-automatic chemiluminescence immunoassay analyzer |
| CN205280740U (en) * | 2015-12-21 | 2016-06-01 | 艾康生物技术(杭州)有限公司 | Chemical illumination immunity analysis instrument |
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