CN105362419A - Medicine composition for treating urinary retention after operation for Qi-stagnation and blood stasis type anorectal disease - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine composition for treating urinary retention after an operation for Qi-stagnation and blood stasis type anorectal disease. The medicine composition comprises the following Chinese medicinal herbs in parts by weight: 5-13 parts of micromelum falcatum (Lour.) Tanaka, 4-8 parts of aralia undulata, 4-8 parts of noble bottle tree husks, 4-8 parts of all-grass of Chinese brake, 4-8 parts of calendula officinalis roots, 4-8 parts of munronia henryi Harms, 4-8 parts of lathyrus davidii Hance and 4-8 parts of radix glycyrrhizae. All of the Chinese medicinal herbs work together to achieve the efficacies of promoting blood and Qi circulation, and relieving pain and inducing diuresis; the medicine composition focus on pathogenesis of urinary retention after the operation for Qi-stagnation and blood stasis type anorectal disease, can improve the urinary catheter pulling out success rate of a patient suffering from urinary retention after the operation, reduces the residual urine volume in a bladder and the bladder capacity, improves the free urine rate, and can remarkably improve postoperative pain states of the patient.

Description

A kind of pharmaceutical composition for the treatment of qi stagnation and blood stasis type anorectal disease postoperative urine retention

Technical field

The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition for the treatment of qi stagnation and blood stasis type anorectal disease postoperative urine retention.

Background technology

Anorectal disease refers to the various diseases occurred on anus, large intestine in broad terms, commonly encountered diseases is kind more than 100 about, and the anorectal disease of narrow sense refers to and occurs in various disease on anus and rectum, commonly encountered diseases is kind more than 30 about, as: internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, anal fissure, anal fistula, perianal abscess, anorectal stricture, anal incontinence, cancer of anal canal and rectal cancer etc.Motherland's medical science is to the understanding of this kind of disease and treat with a long history, defines a set of unique theoretical system, have accumulated abundant Couple herbs, effectively instruct clinical practice.At present, the treatment of China's anorectal disease adopts the combined therapy of Chinese and Western medicine more, and a lot of complicated anorectal disease many employings operation method is treated.Because anus, operation on rectum are to the tractive of anus, rectum and surrounding tissue thereof and damage, cause the generation of postoperative various complication, wherein common with postoperative urine retention.Postoperative urine retention often with postoperative pain, anaesthetize affect, postoperative dressing filling, feces clogs and relevant to rectal mucosal destruction in art.

Research both domestic and external is verified, and long urine retention can cause the permanent irreversible lesion of detrusor, and patient can be caused not in time painful all the life if find or treat, therefore the treatment of anorectal disease postoperative urine retention is particularly important.Doctor trained in Western medicine main diuretic treatment urine retention, clinical effectiveness is general.

Qi stagnation and blood stasis type is the common pattern of syndrome of anorectal disease postoperative urine retention, and patient's disease is seen: urinary obstruction, or logical and not well, flank distension, depressed emotion, or how tired irritability, purplish tongue or have petechia, thready and hesitant pulse.The medicine had not yet to see for such anorectal disease postoperative urine retention is reported.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of pharmaceutical composition for the treatment of qi stagnation and blood stasis type anorectal disease postoperative urine retention.

The present invention is achieved through the following technical solutions:

Treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, be made up of the Chinese medicine of following weight portion:

Bassoon 5-13 part, Radix Araliae undulatae 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, Herba Pteridis multifidae 4-8 part, "root of Potmarigold Calendul" 4-8 part, short top top 4-8 part, Herba lathyri davidii 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the pharmaceutical composition of above-mentioned treatment qi stagnation and blood stasis type anorectal disease postoperative urine retention, is made up of the Chinese medicine of following weight portion:

Bassoon 7-11 part, Radix Araliae undulatae 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, Herba Pteridis multifidae 5-7 part, "root of Potmarigold Calendul" 5-7 part, short top top 5-7 part, Herba lathyri davidii 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, the pharmaceutical composition of above-mentioned treatment qi stagnation and blood stasis type anorectal disease postoperative urine retention, is made up of the Chinese medicine of following weight portion:

Bassoon 9 parts, Radix Araliae undulatae 6 parts, Pericarpium Sterculiae nobilis 6 parts, Herba Pteridis multifidae 6 parts, "root of Potmarigold Calendul" 6 parts, short top top 6 parts, Herba lathyri davidii 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of qi stagnation and blood stasis type anorectal disease postoperative urine retention.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In pharmaceutical composition of the present invention,

Bassoon another name Folium seu Radix Clausenae dentatae, Rhizoma lutina How et chen, Ovum Gallus domesticus Flavus, Cortex Clausenae Excavatae, derive from Rutaceae bassoon Micromelumfalcatum(Lour.) Tanaka, is used as medicine with root, leaf.Bitter in the mouth, pungent, warm in nature.The circulation of qi promoting of function dissipating blood stasis, pain relieving, invigorates blood circulation.Cure mainly venom, the thoracic obstruction, osteopatia sprain.

Radix Araliae undulatae another name HONGCI brain bag, sky, top thorn, Aralia mandshurica, Sedum aizoon L., purplish red umbrella are the root of Araliaceae Radix Araliae undulatae AraliaundulataHand.-Mazz.Bitter in the mouth; Pungent; Cool in nature.Function blood circulation promoting and blood stasis dispelling; Inducing menstruation to relieve menalgia; Expelling wind and removing dampness.Main traumatic injury; Fracture; Mass in the abdomen; Amenorrhea; Dysmenorrhea; Impairment caused by overstrain pain; Rheumatalgia.

Pericarpium Sterculiae nobilis another name Semen Sterculiae Nobilis pod, sterculia nobilis's shell.For the shell of Sterculiaceae plant sterculia nobilis SterculianobilisSmith.Sweet in the mouth; Property is put down.Return small intestine meridian.Function blood-activating and qi-promoting.Main dysentery; Inguinal hernia; Hemorrhoid; Otitis media.

Herba Pteridis multifidae another name Herba Pteridis Multifidae (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), Lycium ruthenicum Murr. (" Yunnan Chinese herbal medicine ").Source is the herb of the bright Herba Pteridis creticae of wind tail Pteridiaceae plant.Nature and flavor are pungent, nontoxic.Light micro-hardship, cold.Function heat-clearing and toxic substances removing, diuresis of blood circulation promoting.Control dysentery, enteritis, urine leaching pain, carbuncle furuncle swells, fracture.

Calendula officinalis another name water rises chrysanthemum, mountain gold chrysanthemum, derives from Compositae Calendula officinalis CalendulaofficinalisL., is used as medicine with root, flower.Lightly seasoned, property is put down.Function root: promoting blood circulation to remove blood stasis, circulation of qi promoting diuresis.Cure mainly lump in the abdomen hernia, cold syndrome of the stomach pain.Flower: removing heat from blood, hemostasis.Cure mainly discharging fresh blood stool.

Short top top call little Herba Munroniae henryi, the little only son and heir, Simao Herba Munroniae henryi, thousand short.For the Herb of Meliaceae plant Yunnan Herba Munroniae henryi MunroniadelavayiFranch..Sweet in the mouth; Micro-hardship; Cool in nature.Function promoting blood circulation and stopping pain; Heat-clearing and toxic substances removing.Main traumatic injury stasis of blood pain; Rheumatic arthritis; Pharyngolaryngitis; Carbuncle furuncle.

Herba lathyri davidii another name Semen Cassiae Sopherae Herba Lathyri quinquenerii, large Semen Pisi sativi.For the seed of leguminous plant Semen Cassiae Sopherae sweet pea LathyrusdavidiiHance.Acrid in the mouth; Warm in nature.Return Liver Channel.Function depressed liver-energy dispersing and QI regulating; Menstruction regulating and pain relieving.Main dysmenorrhea; Have through uncomfortable.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Urine retention belongs in Chinese medicine " difficulty in urination " category, discusses about the etiology and pathogenesis of the difficulty in urination is existing in "Nei Jing", the article pointed out that the cause of disease of this disease mainly comprises: diseases caused by exogenous pathogenic factor six climate exopathogens, internal damage by the excessive seven emotions, eating and drinking without temperance etc.; Sick position is mainly bladder and three Jiao.The present inventor, on the basis of diagnosis and treatment anorectal disease experience for many years, thinks that the Etiological pathogenesis of anorectal disease postoperative urine retention is qi depression to blood stasis, thinks that operation causes qi depression to blood stasis, catharsis is too late, thus affect operation and the gasification function of three burnt water liquid, cause water channel to lead to tune and be obstructed, form the difficulty in urination.In addition, postoperative pain, causes sphincter vesicae spasm, causes dysuria, meets the theory of the traditional Chinese medical science " pain is then obstructed ".Therefore should with " blood-activating and qi-promoting, pain relieving diuresis " for principle treatment qi stagnation and blood stasis type anorectal disease postoperative urine retention.

Pharmaceutical composition of the present invention, its prescription machine is as follows:

Monarch drug: bassoon merit is with dissipating blood stasis circulation of qi promoting, and pain relieving, invigorates blood circulation.

Ministerial drug: Radix Araliae undulatae merit is with blood circulation promoting and blood stasis dispelling; Pericarpium Sterculiae nobilis merit is with blood-activating and qi-promoting.

Adjuvant drug: Herba Pteridis multifidae merit is with diuresis of blood circulation promoting; "root of Potmarigold Calendul" merit with blood circulation promoting and blood stasis dispelling, circulation of qi promoting diuresis; Short top top merit is with promoting blood circulation and stopping pain.Herba lathyri davidii merit with depressed liver-energy dispersing and QI regulating, menstruction regulating and pain relieving.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays blood-activating and qi-promoting altogether, the effect of pain relieving diuresis.The etiology and pathogenesis of the qi stagnation and blood stasis type anorectal disease postoperative urine retention that links closely.The success rate that postoperative urine retention patient extracts catheter can be improved, reduce residual urine volume and bladder capacity, improve and freely urinate speed, and obviously can improve patient's postoperative pain symptom, TCM syndrome is evident in efficacy, contributes to alleviating patient's misery, improve quality of life of patients, have promotional value.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, each crude drug weight proportion is as follows:

Bassoon 9g, Radix Araliae undulatae 6g, Pericarpium Sterculiae nobilis 6g, Herba Pteridis multifidae 6g, "root of Potmarigold Calendul" 6g, short top top 6g, Herba lathyri davidii 6g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, each crude drug weight proportion is as follows:

Bassoon 7g, Radix Araliae undulatae 5g, Pericarpium Sterculiae nobilis 5g, Herba Pteridis multifidae 5g, "root of Potmarigold Calendul" 5g, short top top 5g, Herba lathyri davidii 5g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, each crude drug weight proportion is as follows:

Bassoon 11g, Radix Araliae undulatae 7g, Pericarpium Sterculiae nobilis 7g, Herba Pteridis multifidae 7g, "root of Potmarigold Calendul" 7g, short top top 7g, Herba lathyri davidii 7g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, each crude drug weight proportion is as follows:

Bassoon 13g, Radix Araliae undulatae 8g, Pericarpium Sterculiae nobilis 8g, Herba Pteridis multifidae 8g, "root of Potmarigold Calendul" 8g, short top top 8g, Herba lathyri davidii 8g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, each crude drug weight proportion is as follows:

Bassoon 5g, Radix Araliae undulatae 4g, Pericarpium Sterculiae nobilis 4g, Herba Pteridis multifidae 4g, "root of Potmarigold Calendul" 4g, short top top 4g, Herba lathyri davidii 4g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to pharmaceutical composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose urinary retention after anorectal operation (qi stagnation and blood stasis type) patient 120 example, wherein man 69 example, female 51 example, the mean age (42.48 ± 11.29) year.

1.2 urine retention diagnostic criterias

With reference to the diagnostic criteria of WHO about urine retention: energy voluntary micturition person, residual urine volume >500ml; Can not voluntary micturition, bladder scanning bladder capacity >500ml.

1.3 differential diagnosis in tcm standards

The difficulty in urination " syndrome of qi stagnation and blood stasis " diagnostic criteria with reference in " new Chinese medicine guideline of clinical investigations ": urinary obstruction, or logical and not well, flank distension, depressed emotion, or how tired irritability, purplish tongue or have petechia, thready and hesitant pulse.

1.4 include in and exclusion standard

Inclusive criteria: (1) anal and intestinal disease postoperative urine retention indwelling catheter patient; (2) age 18-60 year; (3) differential diagnosis in tcm belongs to " syndrome of qi stagnation and blood stasis " person; (4) can partner treatment and observer.

Exclusion standard: (1) age is at under-18s, or more than 60 years old patient; (2) female patients of menstrual phase, gestation, age of sucking is in, there is the male patient of prostatic hyperplasia medical history, have urethral catheterization medical history and the narrow medical history person of urinary tract, usually have frequent micturition, urgent micturition, dysuria medical history person, there is acute and chronic urine retention medical history person, have through urinary tract operation medical history person; (3) to have occurred together urinary system calculus, tumor, urinary system infection person simultaneously; (4) be associated with the primary diseases such as acute and chronic Liver and kidney function exhaustion person, hemopoietic system and can not correct rear operator; (5) cerebrovascular disease and cardiovascular diseases medical history person; Diabetic, psychosis medical history, intellectually challenged person and allergic constitution person; Bed is urinated patient.

1.5 Therapeutic Method

Adopt the drug composition oral treatment of the embodiment of the present invention, prescription is as follows: bassoon 9g, Radix Araliae undulatae 6g, Pericarpium Sterculiae nobilis 6g, Herba Pteridis multifidae 6g, "root of Potmarigold Calendul" 6g, short top top 6g, Herba lathyri davidii 6g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, every day potion, sooner or later sub-service.It was a course for the treatment of with 3 days.

1.6 observation index

(1) after treatment, urinary catheter pulls out success rate: pulling out after urinary catheter can the ratio of normal voiding patient; (2) Residual urine measurement after urinating: voluntary micturition person can apply bladder ultrasound scanner mensuration residual urine in 6 hours after pulling out urinary catheter, can not the person of not urinating apply bladder ultrasound scanner monitoring bladder capacity.(3) Qmax measures: patient urinates is urinated pump dynamograph and measured free urinary flow after 2 hours.(4) pain: adopt visual analogue scales to measure (VAS); (5) TCM syndrome integration: with reference to " new Chinese medicine clinical research medication guide principle ", according to nothing, gently, in, heavy, be designated as 0 respectively, 1,2,3 points.

1.7 TCM syndrome therapeutic evaluatioies

" new Chinese medicine clinical research medication guide principle " that evaluation criteria was promulgated with reference to 2002.

1. fully recover: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.

Computing formula: nimodipine method: integration × 100% before (before treatment the rear integration of integration-treatment)/treatment.

1.8 statistical method

SPSS14.0 version statistical software is adopted to analyze.Measurement data represents with mean plus-minus standard deviation, compares and adopts t inspection, represent that difference has statistical significance with P<0.05 before and after treatment.

2. result

Before and after 2.1 treatments, index of correlation compares

After 120 routine urine retention patient treatment 3d, urinary catheter can normal voiding person be 116 examples after pulling out, and tube drawing success rate is 96.7%.After treatment, residual urine volume is (21.37 ± 12.32) ml, (685.45 ± 48.44) ml comparatively before treatment, and obviously reduce, difference has statistical significance (t=4.374, P<0.05); After treatment, bladder capacity is (49.32 ± 16.43) ml, and (623.34 ± 42.15) ml comparatively before treatment obviously reduces, and difference has statistical significance (t=3.273, P<0.05); After treatment, free urinary flow is (39.13 ± 6.36) ml/s, and (3.65 ± 1.12) ml/s comparatively before treatment obviously rises, and difference has statistical significance (t=3.875, P<0.05); After treatment, VAS scoring is (2.12 ± 0.63) point, and (6.93 ± 1.57) point comparatively before treatment obviously reduce, and difference has statistical significance (t=3.303, P<0.05).

TCM syndrome integration and TCM syndrome curative effect before and after 2.2 treatments

(34.99 ± 9.38) point before after treatment, TCM syndrome total mark (5.24 ± 1.43) divides comparatively treatment obviously reduce, and difference has statistical significance (t=3.848, P<0.05); 120 routine patients cure 116 examples, effective 3 examples, effective 1 example, invalid 0 example.Curative effect: cure rate 96.7%, total obvious effective rate 99.2%, total effective rate is 100%.

2.3 safety analysis

Treatment Patients Before And After routine blood test, Liver and kidney merit and electrocardiogram are without significant change, and drug safety is better.

Claims (3)

1. treat a pharmaceutical composition for qi stagnation and blood stasis type anorectal disease postoperative urine retention, be made up of the Chinese medicine of following weight portion:

Bassoon 5-13 part, Radix Araliae undulatae 4-8 part, Pericarpium Sterculiae nobilis 4-8 part, Herba Pteridis multifidae 4-8 part, "root of Potmarigold Calendul" 4-8 part, short top top 4-8 part, Herba lathyri davidii 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the pharmaceutical composition for the treatment of qi stagnation and blood stasis type anorectal disease postoperative urine retention according to claim 1, is characterized in that, be made up of the Chinese medicine of following weight portion:

Bassoon 7-11 part, Radix Araliae undulatae 5-7 part, Pericarpium Sterculiae nobilis 5-7 part, Herba Pteridis multifidae 5-7 part, "root of Potmarigold Calendul" 5-7 part, short top top 5-7 part, Herba lathyri davidii 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the pharmaceutical composition for the treatment of qi stagnation and blood stasis type anorectal disease postoperative urine retention according to claim 3, is characterized in that, be made up of the Chinese medicine of following weight portion:

Bassoon 9 parts, Radix Araliae undulatae 6 parts, Pericarpium Sterculiae nobilis 6 parts, Herba Pteridis multifidae 6 parts, "root of Potmarigold Calendul" 6 parts, short top top 6 parts, Herba lathyri davidii 6 parts, 6 parts, Radix Glycyrrhizae.