CN105362298B - 一种木醋巴布剂及其制备方法 - Google Patents
一种木醋巴布剂及其制备方法 Download PDFInfo
- Publication number
- CN105362298B CN105362298B CN201510872098.4A CN201510872098A CN105362298B CN 105362298 B CN105362298 B CN 105362298B CN 201510872098 A CN201510872098 A CN 201510872098A CN 105362298 B CN105362298 B CN 105362298B
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- water
- cataplasm
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000052 vinegar Substances 0.000 title claims abstract description 37
- 235000021419 vinegar Nutrition 0.000 title claims abstract description 37
- 239000002023 wood Substances 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 44
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 28
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 claims abstract description 22
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 235000011187 glycerol Nutrition 0.000 claims abstract description 14
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 12
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 12
- 239000005995 Aluminium silicate Substances 0.000 claims abstract description 11
- 108010010803 Gelatin Proteins 0.000 claims abstract description 11
- 235000012211 aluminium silicate Nutrition 0.000 claims abstract description 11
- 239000008273 gelatin Substances 0.000 claims abstract description 11
- 229920000159 gelatin Polymers 0.000 claims abstract description 11
- 235000019322 gelatine Nutrition 0.000 claims abstract description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 11
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract description 11
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 21
- 230000008961 swelling Effects 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 238000004821 distillation Methods 0.000 claims description 6
- 239000004745 nonwoven fabric Substances 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 238000000576 coating method Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000000465 moulding Methods 0.000 claims description 5
- 238000010422 painting Methods 0.000 claims description 5
- -1 polyethylene Polymers 0.000 claims description 5
- 229920000573 polyethylene Polymers 0.000 claims description 5
- 230000001681 protective effect Effects 0.000 claims description 5
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108090000526 Papain Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims description 2
- 230000007071 enzymatic hydrolysis Effects 0.000 claims description 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 claims description 2
- 229940088598 enzyme Drugs 0.000 claims description 2
- 238000001976 enzyme digestion Methods 0.000 claims description 2
- 229940055729 papain Drugs 0.000 claims description 2
- 235000019834 papain Nutrition 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 claims 1
- 229940047670 sodium acrylate Drugs 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 14
- 239000003814 drug Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 208000017520 skin disease Diseases 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 238000013019 agitation Methods 0.000 description 3
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000011505 plaster Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 239000003470 adrenal cortex hormone Substances 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- RKHQGWMMUURILY-UHRZLXHJSA-N cortivazol Chemical compound C([C@H]1[C@@H]2C[C@H]([C@]([C@@]2(C)C[C@H](O)[C@@H]1[C@@]1(C)C2)(O)C(=O)COC(C)=O)C)=C(C)C1=CC1=C2C=NN1C1=CC=CC=C1 RKHQGWMMUURILY-UHRZLXHJSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000228245 Aspergillus niger Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010024229 Leprosy Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 241000235342 Saccharomycetes Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 206010065954 Stubbornness Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000008429 bread Nutrition 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000001408 fungistatic effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开一种木醋巴布剂及其制备方法。本发明巴布剂配方为：高岭土15重量份，水50重量份，聚丙烯酸钠1.5～4重量份，明胶7～8重量份，羧甲基纤维素钠1.5～2.5重量份，柠檬酸0.03～0.09重量份，无水氯化铝0.01～0.07重量份，丙三醇23～48重量份，精制木醋液3～7重量份。本发明所述木醋巴布剂黏性适宜，外观平整有光泽，皮肤追随性好且无残留亦无刺激性，可反复贴用，特别适用于顽固性皮肤病的治疗，且该制备工艺简单、稳定、可行。
Description
技术领域
本发明涉及医药技术领域，更具体的说，是涉及一种木醋巴布剂及其制备方法。
背景技术
皮肤病是严重影响人民健康的常见病、多发病之一，如麻风、疥疮、真菌病、皮肤细菌感染等。皮肤病是皮肤受到内外因素的影响后，其形态、结构和功能均发生变化，产生病理过程，并相应地产生各种临床表现。皮肤病的发病率很高，多比较轻，常不影响健康，但少数较重甚至可以危及生命。
目前市场上应用最广泛的皮肤病外用膏剂主要是皮质激素类软膏，其治疗效果较好，是治疗皮肤病的主流药物，但长期使用皮质激素类药物容易对人体产生副作用，如：加重感染以及水盐代谢紊乱。副作用轻者会给皮肤带来一系列的变化，如使表皮组织变薄、皮肤的弹性减弱、皮纹消失以及皮肤的色素发生异常，还可表现为皮肤局部的多毛、干燥或鱼鳞病样变化，这一系列的变化尤以面部用药者表现较为明显，尤其是女性，因女性面部皮肤较薄，容易发生不良反应；副作用重者可导致皮肤表面菌群失调、病情加重及扩散等。上述不良反应一旦发生，就很难在短期内得到改变，有些反应甚至是不可逆的。
木醋液俗名又叫植物酸，是木材、木屑、秸秆等物质在干馏热解过程中产生的气体产物经冷凝而得到的一种黑褐色液体。木醋液中含醋酸、酚系化合物及醇等成分。这些成分具有清洁皮肤、软化角质、杀菌和消毒作用，可用于皮肤病的治疗，对脚臭、体臭的治疗也有一定的功效，此外它还具有活化皮肤细胞的功能。但目前市面上关于木醋液人体药用保健相关产品还更多的只是停留在直接使用木醋原液自行调配层面，这样会造成使用者无法安全、方便、舒适地使用。
巴布剂是一种外用贴膏剂，它源于日本民间惯用的泥罨剂，迄今已有1000多年的历史。至70年代初，巴布剂在日本制药业开始引起了广泛关注。我国在上世纪八十年代初，由原上海中药三厂将巴布剂引入中药，制成关节镇痛膏巴布剂，是国内最早的中药巴布剂品种。巴布剂普遍受到关注是在上世纪九十年代中期，由于橡皮膏、黑膏药等传统膏药的缺点日益突出，使得巴布剂的整体优越性突显。巴布剂由于具有载药量大、生物利用度高、起效快以及使用简便等优势，将在很多方面展现良好开发价值和市场应用前景。若将木醋液开发应用于木醋巴布剂，在保持木醋液原有功效的同时还能提高产品的使用价值和性能，让患者能舒适、安全、有效、方便地使用该产品。
经实验验证得知：木醋液对细菌（包括金黄色葡萄球菌、枯草芽孢杆菌、溶壁微球菌和变形链球菌等）和真菌（包括黑根霉、黑曲霉和酵母菌等）均有明显的抑菌效果。以精制木醋液为主要药效成分而制备木醋巴布剂未见文献报道。
发明内容
本发明的目的在于提供一种木醋巴布剂，该木醋巴布剂配方为：高岭土15重量份，水50重量份，聚丙烯酸钠1.5～4重量份，明胶7～8重量份，羧甲基纤维素钠1.5～2.5重量份，柠檬酸0.03～0.09重量份，无水氯化铝0.01～0.07重量份，丙三醇23～48重量份，精制木醋液含量3～7重量份。
本发明的另一目的是提供上述木醋巴布剂的制备方法，按照下述步骤进行：
（1）将7～8重量份的明胶用适量的水在52～56℃水浴锅中加热搅拌至充分溶胀，加入1.5～2.5重量份的羧甲基纤维素钠并搅拌至溶胀，并添加少量水，得溶液（A）；
（2）将0.01～0.07重量份的无水氯化铝和0.03～0.09重量份的柠檬酸溶在一定量水中，得到溶液（B）；
（3）23～48重量份的丙三醇置于烧杯中在52～56℃水浴条件下加热，将1.5～4重量份的聚丙烯酸钠加入丙三醇中搅拌至分散均匀，添加15重量份的高岭土搅拌至分散均匀后加入适量水，搅拌至充分溶胀，得溶液（C）；
（4）将溶液（A）加入溶液（C）中，搅拌均匀后，加入溶液（B），52～56℃水浴条件下继续加热搅拌至均匀，得到溶液（D）；
（5）向溶液（D）中加入3～7重量份的精制木醋液，52～56℃水浴条件下继续加热搅拌至均匀；成型后涂布，涂布操作时要用玻璃棒趁热均匀涂布在无纺布（7×10cm自制）上，厚度为0.5mm，涂布完毕后，室温放置24小时后盖上聚乙烯保护膜；
上述各步骤添加水的总量为50重量份。
所述精制木醋液的制备方法为：第一步：酶解，取木醋液原液，加入木瓜蛋白酶，进行酶解反应，反应温度54~62℃，反应时间15~45min，pH值6.4~7.2，酶的添加量400~600U/mL；
第二步：蒸馏，将酶解完的木醋液进行蒸馏，先在70±2℃、0.01±0.005MPa条件下进行一次蒸馏，收集90%馏分；将馏分进行二次蒸馏，温度为50±2 ℃，压强为0.01±0.005MPa，收集50%馏分，得到无色木醋液；
第三步：吸附，将二次蒸馏的馏分使用粉末活性炭进行吸附，粉末活性炭的加入量为其体积的5%，室温下吸附1小时。
所述无纺布的尺寸为7×10cm。
本发明的有益效果为：
（1）本发明能针对性治疗皮肤病变伴有的红、肿、热、痛症状，从根本上治疗皮肤病；
（2）本发明采用聚丙烯酸钠作为基质的凝胶骨架剂，自主解决了聚丙烯酸钠的充分溶胀问题，改善和提高木醋巴布剂的质量。
（3）本发明木醋巴布剂对皮肤渗透性好、透气佳、黏性适宜、外观平整有光泽、无残留、无刺激过敏性、皮肤追随性好，可反复贴用，用3天以上对皮肤无刺激，特别适用于顽固性皮肤病的治疗；
（4）本发明的主要有效成分为精制木醋液，对人体基本无副作用、药味小，精制木醋液的工艺相对简单、稳定、可行，适合于工业化大生产。
具体实施方式
下面结合具体实施例对本发明做进一步说明。
实施例1：
本实施例木醋巴布剂由以下原料制得：高岭土15g，水50g，聚丙烯酸钠2.0g，明胶7.0g，羧甲基纤维素钠1.5g，柠檬酸0.09g，无水氯化铝0.07g，丙三醇38g，精制木醋液4g。
制备方法按照如下步骤进行：
（1）7.0g 明胶用15g水在54℃水浴锅中加热搅拌至充分溶胀，加入1.5g 羧甲基纤维素钠并搅拌至溶胀，并添加2g水，得溶液（A）；
（2）将0.07g 无水氯化铝和0.09g 柠檬酸溶于3g水中，得到溶液（B）；
（3）38g丙三醇置于烧杯中在54℃水浴条件下加热，将2.0g聚丙烯酸钠加入丙三醇中搅拌至分散均匀，添加15g高岭土搅拌至分散均匀后加入30g水，搅拌至充分溶胀，得溶液（C）；
（4）将溶液（A）加入溶液（C）中，搅拌均匀后，加入溶液（B），54℃水浴条件下继续加热搅拌至均匀，得到溶液（D）；
（5）向溶液（D）中加入4g精制木醋液，54℃水浴条件下继续加热搅拌至均匀；成型后涂布，涂布操作时要用玻璃棒趁热均匀涂布在无纺布（7×10 cm自制）上，厚度约为0.5mm，涂布完毕后，室温放置24小时后盖上聚乙烯保护膜。
实施例2：
本实施例木醋巴布剂由以下原料制得：高岭土15g，水50g，聚丙烯酸钠2.5g，明胶7.0g，羧甲基纤维素钠1.5g，柠檬酸0.06g，无水氯化铝0.05g，丙三醇33g，精制木醋液6g。
制备方法按照如下步骤进行：
（1）7.0g 明胶用15g水在56℃水浴锅中加热搅拌至充分溶胀，加入1.5g 羧甲基纤维素钠并搅拌至溶胀，并添加2g水，得溶液（A）；
（2）将0.05g 无水氯化铝和0.06g 柠檬酸溶于3g水中，得到溶液（B）；
（3）33g 丙三醇置于烧杯中在56℃水浴条件下加热，将2.5g聚丙烯酸钠加入丙三醇中搅拌至分散均匀，添加15g高岭土搅拌至分散均匀后加入30g水，搅拌至充分溶胀，得溶液（C）；
（4）将溶液（A）加入溶液（C）中，搅拌均匀后，加入溶液（B），56℃水浴条件下继续加热搅拌至均匀，得到溶液（D）；
（5）向溶液（D）中加入6g精制木醋液，56℃水浴条件下继续加热搅拌至均匀；成型后涂布，涂布操作时要用玻璃棒趁热均匀涂布在无纺布（7×10 cm自制）上，厚度约为0.5mm，涂布完毕后，室温放置24小时后盖上聚乙烯保护膜。
实施例3：
本实施例木醋巴布剂由以下原料制得：高岭土15g，水50g，聚丙烯酸钠3.0g，明胶7.0g，羧甲基纤维素钠1.5g，柠檬酸0.06g，无水氯化铝0.05g，丙三醇35g，精制木醋液5g。
制备方法按照如下步骤进行：
（1）7.0g 明胶用15g水在52℃水浴锅中加热搅拌至充分溶胀，加入1.5g 羧甲基纤维素钠并搅拌至溶胀，并添加2g水，得溶液（A）；
（2）将0.05g 无水氯化铝和0.06g 柠檬酸溶于3g水中，得到溶液（B）；
（3）35g 丙三醇置于烧杯中在52℃水浴条件下加热，将3.0g聚丙烯酸钠加入丙三醇中搅拌至分散均匀，添加15g高岭土搅拌至分散均匀后加入30g水，搅拌至充分溶胀，得溶液（C）；
（4）将溶液（A）加入溶液（C）中，搅拌均匀后，加入溶液（B），52℃水浴条件下继续加热搅拌至均匀，得到溶液（D）；
（5）向溶液（D）中加入5g精制木醋液，52℃水浴条件下继续加热搅拌至均匀；成型后涂布，涂布操作时要用玻璃棒趁热均匀涂布在无纺布（7×10 cm自制）上，厚度约为0.5mm，涂布完毕后，室温放置24小时后盖上聚乙烯保护膜。
按中国药典2010年版一部规定，采用斜面滚球测定方法对本实施例制备的木醋巴布剂进行初粘力测定；同时，对巴布剂的外观、皮肤追随性、基质残留和反复揭贴性等进行综合感官评价。所制备的木醋巴布剂黏性适宜，外观平整有光泽，皮肤追随性好且无残留亦无刺激性。且该工艺简单、稳定、可行。
需要注意的是，以上列举的仅是本发明的若干个具体实施例。显然，本发明不限于以上实施例，还可以有许多变形。本领域的普通技术人员能从本发明公开的内容直接导出或联想到的所有变形，均应认为是本发明的保护范围。
Claims (3)
1.一种木醋巴布剂，其特征是，所述木醋巴布剂配方为：高岭土15重量份，水50重量份，聚丙烯酸钠1.5～4重量份，明胶7～8重量份，羧甲基纤维素钠1.5～2.5重量份，柠檬酸0.03～0.09重量份，无水氯化铝0.01～0.07重量份，丙三醇23～48重量份，精制木醋液含量3～7重量份。
2.根据权利要求1所述木醋巴布剂，其特征是，所述精制木醋液的制备方法为：第一步：酶解，取木醋液原液，加入木瓜蛋白酶，进行酶解反应，反应温度54~62℃，反应时间15~45min，pH值6.4~7.2，酶的添加量400~600U/mL；
第二步：蒸馏，将酶解完的木醋液进行蒸馏，先在70±2℃、0.01±0.005MPa条件下进行一次蒸馏，收集90%馏分；将馏分进行二次蒸馏，温度为50±2 ℃，压强为0.01±0.005MPa，收集50%馏分，得到无色木醋液；
第三步：吸附，将二次蒸馏的馏分使用粉末活性炭进行吸附，粉末活性炭的加入量为其体积的5%，室温下吸附1小时。
3.一种如权利要求1所述的木醋巴布剂的制备方法，其特征是，按照下述步骤进行：
将7～8重量份的明胶用适量的水在52～56℃水浴锅中加热搅拌至充分溶胀，加入1.5～2.5重量份的羧甲基纤维素钠并搅拌至溶胀，并添加少量水，得溶液（A）；
将0.01～0.07重量份的无水氯化铝和0.03～0.09重量份的柠檬酸溶在一定量水中，得到溶液（B）；
23～48重量份的丙三醇置于烧杯中在52～56℃水浴条件下加热，将1.5～4重量份的聚丙烯酸钠加入丙三醇中搅拌至分散均匀，添加15重量份的高岭土搅拌至分散均匀后加入适量水，搅拌至充分溶胀，得溶液（C）；
将溶液（A）加入溶液（C）中，搅拌均匀后，加入溶液（B），52～56℃水浴条件下继续加热搅拌至均匀，得到溶液（D）；
向溶液（D）中加入3～7重量份的精制木醋液，52～56℃水浴条件下继续加热搅拌至均匀；成型后涂布，涂布操作时要用玻璃棒趁热均匀涂布在自制的7×10cm无纺布上，厚度为0.5mm，涂布完毕后，室温放置24小时后盖上聚乙烯保护膜；
上述各步骤添加水的总量为50重量份。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510872098.4A CN105362298B (zh) | 2015-12-03 | 2015-12-03 | 一种木醋巴布剂及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510872098.4A CN105362298B (zh) | 2015-12-03 | 2015-12-03 | 一种木醋巴布剂及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105362298A CN105362298A (zh) | 2016-03-02 |
| CN105362298B true CN105362298B (zh) | 2019-05-17 |
Family
ID=55365252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510872098.4A Expired - Fee Related CN105362298B (zh) | 2015-12-03 | 2015-12-03 | 一种木醋巴布剂及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105362298B (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965814A (zh) * | 2006-11-03 | 2007-05-23 | 昆明制药集团股份有限公司 | 草乌甲素巴布剂 |
| CN101297942A (zh) * | 2008-06-25 | 2008-11-05 | 浙江林学院 | 一种含植醋液的去痒消肿剂及其制备方法 |
-
2015
- 2015-12-03 CN CN201510872098.4A patent/CN105362298B/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965814A (zh) * | 2006-11-03 | 2007-05-23 | 昆明制药集团股份有限公司 | 草乌甲素巴布剂 |
| CN101297942A (zh) * | 2008-06-25 | 2008-11-05 | 浙江林学院 | 一种含植醋液的去痒消肿剂及其制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| 中药巴布剂的基质研究进展;呼永河等;《医学综述》;20120731;第18卷(第13期);2093-2096 |
| 中药巴布剂的研究概况与展望;王法龙等;《光明中医》;20140430;第29卷(第4期);876-882 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105362298A (zh) | 2016-03-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105816908B (zh) | 一种防水型液体创口保护膜及其制备方法 | |
| CN104983989A (zh) | 一种治疗痛经的中药及其凝胶膏剂和制备方法 | |
| CN107362079A (zh) | 一种具有抗菌祛痘功效的美白保湿面膜及其制备方法 | |
| CN102485237B (zh) | 青蒿酿液及其酿制技术 | |
| CN105362298B (zh) | 一种木醋巴布剂及其制备方法 | |
| CN103272133A (zh) | 一种用于消炎止血的发酵物的制备方法 | |
| CN105963243B (zh) | 一种治疗寻常痤疮的龙脑香樟精油缓释乳膏及其制备方法 | |
| CN104490976A (zh) | 一种复方紫草止痒湿疹药物 | |
| CN104257638A (zh) | 一种治疗风寒痹症疼痛的中药巴布剂及制备方法 | |
| CN102727579A (zh) | 一种用于治疗口腔溃疡的药物组合物 | |
| CN103432049B (zh) | 一种具有除臭作用的组合物 | |
| CN103212112B (zh) | 一种含有天然肉桂醛抗菌消炎润滑型导尿管及其制备方法 | |
| CN103432478B (zh) | 一种治疗灰指甲的中药配方及其制备方法 | |
| CN102824363B (zh) | 抗菌剂 | |
| CN103536450B (zh) | 祛痘外用制品及其有效成分制备方法 | |
| CN108451816A (zh) | 一种抑菌消炎祛痘组合物 | |
| CN108514529A (zh) | 一种美白化妆品用中药提取物的提取方法及其用途 | |
| CN104288278A (zh) | 美洲大蠊与地榆的联合用药新用途 | |
| CN104666531A (zh) | 一种小儿退热贴及其制备方法 | |
| CN102178915A (zh) | 一种生发素 | |
| CN104095869A (zh) | 一种治疗丘疹性荨麻疹的乳膏及其制备方法 | |
| CN105343097A (zh) | 一种含有咖啡因的组合物及其应用和制作方法 | |
| CN107823301A (zh) | 一种治疗灰指甲的外用药液及其制备方法 | |
| CN101953879B (zh) | 一种快速、高效防治猪高热病的微生态制剂 | |
| CN107440979A (zh) | 一种中草药美白面膜及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190517 Termination date: 20191203 |