CN105362157A - Antibacterial liquid soap for washing hands in surgical operation and preparation technology of antibacterial liquid soap - Google Patents

Antibacterial liquid soap for washing hands in surgical operation and preparation technology of antibacterial liquid soap Download PDF

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Publication number
CN105362157A
CN105362157A CN201510931564.1A CN201510931564A CN105362157A CN 105362157 A CN105362157 A CN 105362157A CN 201510931564 A CN201510931564 A CN 201510931564A CN 105362157 A CN105362157 A CN 105362157A
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China
Prior art keywords
parts
liquid soap
antibacterial liquid
seed oil
hands
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CN201510931564.1A
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Chinese (zh)
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CN105362157B (en
Inventor
王金强
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Shandong Doctor That Disappears Sterilizes Science And Technology Co Ltd
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Shandong Doctor That Disappears Sterilizes Science And Technology Co Ltd
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Publication of CN105362157A publication Critical patent/CN105362157A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43—Guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Abstract

The invention relates to antibacterial liquid soap for washing hands in a surgical operation and a preparation technology of the antibacterial liquid soap. The antibacterial liquid soap is prepared from the following components in parts by weight: 20-30 parts of green grape seed oil, 120-150 parts of peony seed oil, 0.5-1.0 part of grapefruit extract, 1.5-2.5 parts of oleuropein, 1.0-2.0 parts of chlorhexidine gluconate, 0.5-1.0 part of natural wild chrysanthemum flower extract, 2.2-3.0 parts of potassium hydroxide, 0.5-3.0 parts of sodium cocoyl acid isethionate, and the balance of water. The antibacterial liquid soap does not contain phosphates, has the natural features, is free of irritation to the skin, is safe and reliable, belongs to an ultralow-foaming washing product, and is particular suitable for rinsing; a special calcium soap dispersing agent is specially added, so that the detergency of the antibacterial liquid soap is strong; the natural wild chrysanthemum flower extracting liquid is added, so that the antibacterial liquid soap is refreshing and comfortable, moist, mild, and rich in aroma; after the antibacterial liquid soap is used for washing hands, after-fragrance is left on the hands; and the antibacterial liquid soap has the obvious bacteriostasis for staphylococcus aureus and candida albicans.

Description

The antibacterial soap lye of washing one's hands for surgical operation and preparation technology thereof
Technical field
The invention belongs to disinfectant solution preparing technical field, be specifically related to a kind of antibacterial soap lye of washing one's hands for surgical operation and preparation technology thereof.
Background technology
Hospital is the place that invasive organism is intensive, and medical worker needs the skin contacting all kinds of patient, the body surface in body fluid and various hospital facility.Thus, various pathogenic microorganism can field planting to it on hand, caused the generation of hospital infection by the contact transmission of medical worker.
Look back the historical progress of hand hygiene development, as far back as 1800, Hungarian obstetrician Semmelweis (1818-1865) Late Cambrian was washed one's hands the effect prevented hospital infection in obstetric delivery patient.The hypothesis reason that he proposes medicine for treating postpartum fever infects, and infers and strengthen the important measures that hospital personnel hand hygiene compliance is prevention and corntrol hospital infection.Thus, the prelude of hand hygiene by health care workers has been opened.
Current hand hygiene is one of most important measure in hospital infection control, along with the increase of nosocomial infection incidence, patient burden increases the weight of, and disease multiformity infects with treatment complexity and day by day serious multi-drug resistant bacteria the phenomenon that takes place frequently, and hand hygiene more and more comes into one's own.
Summary of the invention
The invention provides a kind of antibacterial soap lye of washing one's hands for surgical operation and preparation technology thereof, with prevention and corntrol hospital infection.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of antibacterial soap lye of washing one's hands for surgical operation, be made up of green grapes seed oil, peony seed oil, grapefruit extract, oleuropein, chlorhexidine gluconate, natural chrysanthemum indicum flower extract, potassium hydroxide, sodium cocoyl isethionate and water, wherein the service property (quality) number of each component is green grapes seed oil 20 ~ 30 parts; Peony seed oil 120 ~ 150 parts; Grapefruit extract 0.5 ~ 1.0 part; Oleuropein 1.5 ~ 2.5 parts; Chlorhexidine gluconate 1.0 ~ 2.0 parts; Natural chrysanthemum indicum flower extract 0.5 ~ 1.0 part; Potassium hydroxide 2.2 ~ 3.0 parts; Sodium cocoyl isethionate 0.5 ~ 3.0 part, surplus is water.
The preparation technology of above-mentioned antibacterial soap lye of washing one's hands for surgical operation, concrete steps are as follows:
(1) taking green grapes seed oil joins in material-compound tank with peony seed oil, is heated to 80 DEG C ~ 90 DEG C, stirs 30min until stir;
(2), after taking the potassium hydroxide use 1kg water dissolution of 2.2 ~ 3.0 parts, join in material-compound tank, fully stir 7 ~ 8h, until saponification is complete;
(3) take grapefruit extract and oleuropein joins in material-compound tank, stir 30 minutes;
(4) excess water is added, until soap base dissolves completely;
(5) add chlorhexidine gluconate, stir 30min, transparent faint yellow watery to soap lye;
(6) add sodium cocoyl isethionate, stir 30min;
(7) add natural chrysanthemum indicum flower extract, continue to stir 30min, stop heating, namely obtain the antibacterial soap lye of pale yellow transparent.
In formula of the present invention:
1, green grapes seed oil: to be seed of Fructus Vitis viniferae form via five-star mode of colding pressing is refining Oleum Vitis viniferae, in beautiful and natural faint yellow or light green, be quite welcome in base oil and effect tall and erect one of kind.Oleum Vitis viniferae has the characteristic of Nantural non-toxic, containing abundant vitamin, mineral and protein, is applicable to various skin and uses, without sensitization phenomenon.Oleum Vitis viniferae has two kinds of very important elements, linoleic acid and proanthocyanidins.Linoleic acid can resist free radical, aging resistance, helps to absorb vitamin C and E, and the elasticity of strengthening blood circulation, reduces ultraviolet injury, and the collagen protein in protection skin, improves venous engorgement and edema, prevention melanin deposition.Proanthocyanidin has protection blood vessel elasticity, and protection skin avoids ultraviolet afflicting with great suffering torment, and the destruction of prevention collagen fiber and elastic fiber, makes skin keep due elasticity and tension force, avoids skin sagging and wrinkle to produce.Penetration is strong, and salubrious non-greasy, is very easily absorbed by the skin, and any skin quality is all applicable.
2, peony seed oil: extract from seed of Flos Moutan core, extract through methods such as milling process, traditional extraction method, supercritical carbon dioxide fluid extraction.This raw material is golden transparent oily liquids.External has following functions: 1, sun-proof, radioprotective.2, skin-protecting face nursing, defying age, strengthens skin exquisiteness and elasticity, wrinkle resistant speckle dispelling.3, antiinflammatory, sterilization, antipruritic, remove comedo and pigmentation.Belong to pure natural, organic, pollution-free material.
3, grapefruit extract: this raw material is brown ceramic powder, and its Main Function is: grapefruit seed flavone is mainly antibacterial, antiinflammatory, and antiviral has anti-oxidation function, the function of anti-bacterial, anti-itching.
4, oleuropein: CAS:32619-42-4 is a kind of active ingredient, has powerful antibacterium and ntiviral characteristic, also has extremely strong oxidation resistance.Antioxidation, broad-spectrum antibacterial action.Skin care item are used for can promoting the former protein renaturation of skin in skin care item, correct aging vestige, reappear smooth without microgroove, young resilient skin, naturally the destruction causing skin by being oxidized is resisted, more from UV uv damage, effectively maintain the tender and elasticity of skin, reach the effect of holding up skin, skin care.
5, natural chrysanthemum indicum flower extract: pure and fresh refreshing clean, moist bland odour is strong, defensive position of washing one's hands leaves lingering fragrance, allows people feel easily comfortable.
6, chlorhexidine gluconate: be a kind of wide-spectrum bactericide, stronger than disinfectants such as bromo geramines to the antibacterial action of Gram-positive and negative bacterium, even if still effective when having serum, blood etc. to exist.
7, sodium cocoyl isethionate: belong to lime soap dispersant, white, to micro-yellow solid, has good surface activity; foaming abundancy, dense, in butyrous; to skin and eyes gentleness, unduly defat, brings lubrication after washing; comfortable, silkiness is experienced, and has good lime soap dispersing power; stable in hard water; nontoxic, non-stimulated, biological degradability is good.
Antibacterial soap lye of the present invention not phosphate-containing, and there is natural characteristic, to no skin irritation, safe and reliable; Belong to ultralow alveolitoid cleaning product, easier rinsing, saved with water and any material can not have been remained on hand; Uniqueness with the addition of extraordinary lime soap dispersant, and its detergency is stronger; With the addition of natural chrysanthemum indicum flower extracting solution, pure and fresh refreshing clean, moist bland odour is strong, and defensive position of washing one's hands leaves lingering fragrance; To staphylococcus aureus and Candida albicans, there is obvious bacteriostasis.
Detailed description of the invention
A kind of antibacterial soap lye of washing one's hands for surgical operation, be made up of green grapes seed oil, peony seed oil, grapefruit extract, oleuropein, chlorhexidine gluconate, natural chrysanthemum indicum flower extract, potassium hydroxide, sodium cocoyl isethionate and water, wherein the service property (quality) number of each component is green grapes seed oil 20 ~ 30 parts; Peony seed oil 120 ~ 150 parts; Grapefruit extract 0.5 ~ 1.0 part; Oleuropein 1.5 ~ 2.5 parts; Chlorhexidine gluconate 1.0 ~ 2.0 parts; Natural chrysanthemum indicum flower extract 0.5 ~ 1.0 part; Potassium hydroxide 2.2 ~ 3.0 parts; Sodium cocoyl isethionate 0.5 ~ 3.0 part, surplus is water.
The preparation technology of above-mentioned antibacterial soap lye of washing one's hands for surgical operation, concrete steps are as follows:
(1) taking green grapes seed oil joins in material-compound tank with peony seed oil, is heated to 80 DEG C ~ 90 DEG C, stirs 30min until stir;
(2), after taking the potassium hydroxide use 1kg water dissolution of 2.2 ~ 3.0 parts, join in material-compound tank, fully stir 7 ~ 8h, until saponification is complete;
(3) take grapefruit extract and oleuropein joins in material-compound tank, stir 30 minutes;
(4) excess water is added, until soap base dissolves completely;
(5) add chlorhexidine gluconate, stir 30min, transparent faint yellow watery to soap lye;
(6) add sodium cocoyl isethionate, stir 30min;
(7) add natural chrysanthemum indicum flower extract, continue to stir 30min, stop heating, namely obtain the antibacterial soap lye of pale yellow transparent.
Antibacterial soap lye of the present invention not phosphate-containing, and there is natural characteristic, to no skin irritation, safe and reliable; Belong to ultralow alveolitoid cleaning product, easier rinsing, saved with water and any material can not have been remained on hand; Uniqueness with the addition of extraordinary lime soap dispersant, and its detergency is stronger; With the addition of natural chrysanthemum indicum flower extracting solution, pure and fresh refreshing clean, moist bland odour is strong, and defensive position of washing one's hands leaves lingering fragrance; To staphylococcus aureus and Candida albicans, there is obvious bacteriostasis; by the result of study display that the present inventor is long-term; after using the natural soap lye of this formula to wash one's hands; the reducing amount of hand bacterium amount is obviously more than the bacterium amount reduced with alcohols and hibitane class hand disinfectant; and layer protecting film can be formed at hand; durable antibiotic, reason is that they can be combined with keratodermatitis, plays its lasting vigor.

Claims (2)

1. an antibacterial soap lye of washing one's hands for surgical operation, it is characterized in that being made up of green grapes seed oil, peony seed oil, grapefruit extract, oleuropein, chlorhexidine gluconate, natural chrysanthemum indicum flower extract, potassium hydroxide, sodium cocoyl isethionate and water, wherein the service property (quality) number of each component is green grapes seed oil 20 ~ 30 parts; Peony seed oil 120 ~ 150 parts; Grapefruit extract 0.5 ~ 1.0 part; Oleuropein 1.5 ~ 2.5 parts; Chlorhexidine gluconate 1.0 ~ 2.0 parts; Natural chrysanthemum indicum flower extract 0.5 ~ 1.0 part; Potassium hydroxide 2.2 ~ 3.0 parts; Sodium cocoyl isethionate 0.5 ~ 3.0 part, surplus is water.
2. the preparation method of antibacterial soap lye of washing one's hands for surgical operation according to claim 1, is characterized in that concrete steps are as follows:
(1) taking green grapes seed oil joins in material-compound tank with peony seed oil, is heated to 80 DEG C ~ 90 DEG C, stirs 30min until stir;
(2), after taking the potassium hydroxide use 1kg water dissolution of 2.2 ~ 3.0 parts, join in material-compound tank, fully stir 7 ~ 8h, until saponification is complete;
(3) take grapefruit extract and oleuropein joins in material-compound tank, stir 30 minutes;
(4) excess water is added, until soap base dissolves completely;
(5) add chlorhexidine gluconate, stir 30min, transparent faint yellow watery to soap lye;
(6) add sodium cocoyl isethionate, stir 30min;
(7) add natural chrysanthemum indicum flower extract, continue to stir 30min, stop heating, namely obtain the antibacterial soap lye of pale yellow transparent.
CN201510931564.1A 2015-12-15 2015-12-15 The antibacterial soap lye and its preparation process washed one's hands for surgical operation Active CN105362157B (en)

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Application Number Priority Date Filing Date Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205942A (en) * 2019-03-28 2020-05-29 铜仁学院 Manual baby hand-washing mousse

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010467A1 (en) * 1997-08-21 1999-03-04 Imperial Chemical Industries Plc Synthetic detergent formulations
CN102911815A (en) * 2012-10-31 2013-02-06 刘文锋 Peony seed oil soap and manufacturing method thereof
CN103211805A (en) * 2013-04-18 2013-07-24 江苏健裕健康医疗器械有限公司 Chlorhexidine gluconate composite disinfectant
CN103751058A (en) * 2014-01-10 2014-04-30 河南科技大学 Peony skin care product and preparation method thereof
CN104357242A (en) * 2014-11-12 2015-02-18 骆志明 Pure traditional Chinese medicine hand-washing soap solution with skin-care and sterilization effects
CN104886268A (en) * 2014-03-06 2015-09-09 洛阳春魁农业开发有限公司 Grape seed oil-containing peony seed blend oil and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999010467A1 (en) * 1997-08-21 1999-03-04 Imperial Chemical Industries Plc Synthetic detergent formulations
CN102911815A (en) * 2012-10-31 2013-02-06 刘文锋 Peony seed oil soap and manufacturing method thereof
CN103211805A (en) * 2013-04-18 2013-07-24 江苏健裕健康医疗器械有限公司 Chlorhexidine gluconate composite disinfectant
CN103751058A (en) * 2014-01-10 2014-04-30 河南科技大学 Peony skin care product and preparation method thereof
CN104886268A (en) * 2014-03-06 2015-09-09 洛阳春魁农业开发有限公司 Grape seed oil-containing peony seed blend oil and preparation method thereof
CN104357242A (en) * 2014-11-12 2015-02-18 骆志明 Pure traditional Chinese medicine hand-washing soap solution with skin-care and sterilization effects

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111205942A (en) * 2019-03-28 2020-05-29 铜仁学院 Manual baby hand-washing mousse

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