CN105343930B - 利用天然含镁的方解石制备可降解的人工骨材料的方法 - Google Patents
利用天然含镁的方解石制备可降解的人工骨材料的方法 Download PDFInfo
- Publication number
- CN105343930B CN105343930B CN201510850022.1A CN201510850022A CN105343930B CN 105343930 B CN105343930 B CN 105343930B CN 201510850022 A CN201510850022 A CN 201510850022A CN 105343930 B CN105343930 B CN 105343930B
- Authority
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- China
- Prior art keywords
- artificial bone
- phosphate
- phase
- calcite
- starfish
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 85
- 239000000463 material Substances 0.000 title claims abstract description 62
- 229910021532 Calcite Inorganic materials 0.000 title claims abstract description 41
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 239000011777 magnesium Substances 0.000 title claims abstract description 24
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title abstract description 20
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 75
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 55
- 238000001027 hydrothermal synthesis Methods 0.000 claims abstract description 51
- 241000258957 Asteroidea Species 0.000 claims abstract description 45
- 241000257465 Echinoidea Species 0.000 claims abstract description 41
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 38
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 38
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 38
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 17
- 235000011010 calcium phosphates Nutrition 0.000 claims abstract description 17
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 12
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 16
- 238000004140 cleaning Methods 0.000 claims description 15
- VWDWKYIASSYTQR-YTBWXGASSA-N sodium;dioxido(oxo)azanium Chemical compound [Na+].[O-][15N+]([O-])=O VWDWKYIASSYTQR-YTBWXGASSA-N 0.000 claims description 14
- 230000007547 defect Effects 0.000 claims description 13
- 239000008367 deionised water Substances 0.000 claims description 13
- 229910021641 deionized water Inorganic materials 0.000 claims description 13
- 239000005416 organic matter Substances 0.000 claims description 11
- 239000007795 chemical reaction product Substances 0.000 claims description 9
- 230000035876 healing Effects 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 230000035484 reaction time Effects 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 4
- 229910000388 diammonium phosphate Inorganic materials 0.000 claims description 4
- 235000019838 diammonium phosphate Nutrition 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 2
- 229910000395 dimagnesium phosphate Inorganic materials 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 238000005245 sintering Methods 0.000 abstract description 2
- 239000012620 biological material Substances 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 abstract 1
- 239000000919 ceramic Substances 0.000 description 14
- 239000000047 product Substances 0.000 description 13
- 239000002245 particle Substances 0.000 description 11
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 7
- 238000001035 drying Methods 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 230000015556 catabolic process Effects 0.000 description 5
- 238000006731 degradation reaction Methods 0.000 description 5
- 229920002451 polyvinyl alcohol Polymers 0.000 description 5
- 229940068984 polyvinyl alcohol Drugs 0.000 description 5
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 238000002441 X-ray diffraction Methods 0.000 description 4
- -1 phosphoric acid hydrogen Chemical class 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000002002 slurry Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 238000010603 microCT Methods 0.000 description 3
- 239000004570 mortar (masonry) Substances 0.000 description 3
- YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003462 bioceramic Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 229960000935 dehydrated alcohol Drugs 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000005445 natural material Substances 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- DMGNFLJBACZMRM-UHFFFAOYSA-N O[P] Chemical compound O[P] DMGNFLJBACZMRM-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000258120 Paracentrotus lividus Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B25/00—Phosphorus; Compounds thereof
- C01B25/16—Oxyacids of phosphorus; Salts thereof
- C01B25/26—Phosphates
- C01B25/32—Phosphates of magnesium, calcium, strontium, or barium
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (7)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510850022.1A CN105343930B (zh) | 2015-11-30 | 2015-11-30 | 利用天然含镁的方解石制备可降解的人工骨材料的方法 |
PCT/CN2016/104298 WO2017092540A1 (zh) | 2015-11-30 | 2016-11-02 | 利用天然含镁的方解石制备可降解的人工骨材料的方法 |
Applications Claiming Priority (1)
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CN201510850022.1A CN105343930B (zh) | 2015-11-30 | 2015-11-30 | 利用天然含镁的方解石制备可降解的人工骨材料的方法 |
Publications (2)
Publication Number | Publication Date |
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CN105343930A CN105343930A (zh) | 2016-02-24 |
CN105343930B true CN105343930B (zh) | 2019-01-22 |
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Country Status (2)
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CN (1) | CN105343930B (zh) |
WO (1) | WO2017092540A1 (zh) |
Families Citing this family (3)
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CN105343930B (zh) * | 2015-11-30 | 2019-01-22 | 中国科学院金属研究所 | 利用天然含镁的方解石制备可降解的人工骨材料的方法 |
CN105948012B (zh) * | 2016-05-05 | 2020-02-18 | 中国科学院金属研究所 | 低温条件下制备β相磷酸三钙晶体材料的方法 |
CN108298512B (zh) * | 2018-05-08 | 2020-09-22 | 西南交通大学 | 一种相成分可调的磷酸钙的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3929971A (en) * | 1973-03-30 | 1975-12-30 | Research Corp | Porous biomaterials and method of making same |
KR100786312B1 (ko) * | 2006-05-03 | 2007-12-17 | 박진우 | 칼슘 포스페이트의 제조 방법 및 이에 의해 제조된 칼슘포스페이트 |
CN101306806B (zh) * | 2008-06-30 | 2010-09-29 | 广西大学 | 一种合成羟基磷灰石的方法 |
KR101041784B1 (ko) * | 2009-06-26 | 2011-06-17 | (주)시지바이오 | 골 재생용 조성물 |
CN105084336B (zh) * | 2014-05-23 | 2017-09-15 | 中国科学院金属研究所 | 一种两相磷酸钙材料及其制备方法和两相磷酸钙人工骨陶瓷 |
CN104147638B (zh) * | 2014-07-18 | 2016-05-04 | 中国科学院金属研究所 | 一种三维连通多孔人工骨支架及其制备方法和应用 |
CN105343930B (zh) * | 2015-11-30 | 2019-01-22 | 中国科学院金属研究所 | 利用天然含镁的方解石制备可降解的人工骨材料的方法 |
-
2015
- 2015-11-30 CN CN201510850022.1A patent/CN105343930B/zh active Active
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2016
- 2016-11-02 WO PCT/CN2016/104298 patent/WO2017092540A1/zh active Application Filing
Also Published As
Publication number | Publication date |
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WO2017092540A1 (zh) | 2017-06-08 |
CN105343930A (zh) | 2016-02-24 |
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Effective date of registration: 20201224 Address after: 110121 3-28, building 4, Science Park, No. 37, Daoyi South Street, Shenbei New District, Shenyang City, Liaoning Province Patentee after: Shenyang Xinghui Medical Technology Co.,Ltd. Address before: 110016 No. 72, Wenhua Road, Shenhe District, Liaoning, Shenyang Patentee before: INSTITUTE OF METAL RESEARCH CHINESE ACADEMY OF SCIENCES |
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Effective date of registration: 20210208 Address after: No. 1987, Jiaotong Avenue, Suizhou City, Hubei Province Patentee after: HUBEI SHUANGXING PHARMACEUTICAL Co.,Ltd. Address before: 110121 3-28, building 4, Science Park, No. 37, Daoyi South Street, Shenbei New District, Shenyang City, Liaoning Province Patentee before: Shenyang Xinghui Medical Technology Co.,Ltd. |
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Denomination of invention: Method for preparing degradable artificial bone material by using natural calcite containing magnesium Effective date of registration: 20211105 Granted publication date: 20190122 Pledgee: Suizhou branch of Bank of China Limited Pledgor: Hubei Shuangxing Pharmaceutical Co., Ltd Registration number: Y2021980012021 |
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