CN105343513A - Traditional Chinese medicine composition having blood activating and speckles removing effects and for treating butterfly rash and chloasma - Google Patents

Abstract

A traditional Chinese medicine composition having blood activating and speckles removing effects and for treating butterfly rash and chloasma comprises herbs for oral administration: Radix et Rhizoma Rhodiolae 10-20 parts, Radix Angelicae Sinensis 10-20 parts, Folium Rhododendri Simsii 10-20 parts, Rhizoma Chuanxiong 10-20 parts, Radix Astragali 10-20 parts, Semen Persicae 10-20 parts, Flos Carthami 10-20 parts, Rhizoma Polygonati Odorati 10-20 parts, Fructus Gardeniae 10-20 parts, Radix Polygoni Multiflori Preparata 10-20 parts, Rhizoma Atractylodis Macrocephalae 10-20 parts, Radix Paeoniae Rubra 10-20 parts, Fructus Mori 10-20 parts, Herba Leonuri 10-20 parts, Semen Plantaginis 10-20 parts, Fructus Ligustri Lucidi 10-20 parts, Radix Aucklandiae 10-20 parts, Radix Bupleuri 10-20 parts, Margarita 10-20 parts, Ramulus Cinnamomi 10-20 parts, Flos Albiziae 10-20 parts, and Herba Artemisiae Anomalae 10-20 parts. The composition is effective in activating blood and promoting qi circulation and removing speckles and acnes, is applicable to the treatment of chloasma and butterfly rash caused by qi and blood stasis and skin nutrition loss, and can remove the chloasma and butterfly rash by internal regulation and external nourishing.

Description

A kind of speckle removing Chinese medicine composition of invigorating blood circulation for the treatment of butterfly spot, chloasma

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly a kind of speckle removing Chinese medicine composition of invigorating blood circulation for the treatment of butterfly spot, chloasma.

Background technology

The butterfly spot cause of disease it be unclear that, and is more common in women, and in blood, estrogen level height is main cause.Its morbidity is relevant with gestation, Long-term Oral contraceptive, menoxenia.Also the patients such as some female reproductive system illness, tuberculosis, cancer, chronic alcoholism, hepatopathys are seen.Daylight can impel morbidity.Male patient accounts for 10%, and having research to think, that male falls ill is relevant with heredity.Infringement is yellowish-brown or dark brown patch, and be often symmetrically distributed in cheekbone buccal, also can involve socket of the eye week, forehead, upper lip and nose, edge is generally more obvious.Without subjective symptom and general malaise.The mottle depth and season, Exposure to Sunlight, endocrine factors is relevant.Psychentonia, stays up late, and fatigue can increase the weight of skin lesion.According to yellowish-brown erythra, be more common in young and middle-aged women and predilection site can be made a definite diagnosis, need and freckle, riehl's melanosis, nevus fuscoceruleus ophthalmomaxillaris, naevus fuscocaerules zygomaticus is differentiated.Butterfly spot there is no satisfied therapy now.As found cause of disease person's removing as far as possible.The chloasma caused by contraceptive, should cut out, but not necessarily disappear in a short time.

Chloasma is a kind of metabolism of pigment abnormity dermatosis betiding face, and show as the yellowish-brown or light black patch of symmetry that facial area size does not wait, divide on skin, that comforts is not in the way.Primary disease is called " chloasma ", " chloasma hepaticum ", " dusty face " etc. by motherland's medical science.The cause of disease of the functional disorders such as the existing obvious endocrine of the generation due to primary disease, nervous system or digestive system can be followed, the chemical factors being subject to again many external worlds, as the impact of Exposure to Sunlight, thermal radiation, wound (scratch, friction etc.), contact photosensitizer or compound, the agent of external silvery, mercurial etc., therefore generally advocates treatment of the inside combined with the outside.

Said ailment said due to cold or exposure is like can understand from the angle of broad sense in the etiology and pathogenesis of butterfly spot, chloasma for the traditional Chinese medical science, and the Exposure to Sunlight be familiar with as modern medicine, thermal radiation, contact photosensitizer or compound, the agent of external silvery, mercurial etc., all can be summed up as ailment said due to cold or exposure.Therefore, the medicine for external use controlled for ailment said due to cold or exposure can also in conjunction with modern pharmacology result of study, compatibility anti-ultraviolet, radiation-resistant medicine.Also should take the circumstances into consideration to add said medicine to make treatment have something to base in conjunction with the achievement in research of modern pharmacology in formula.In addition, for exfoliative medicine, as Radix Aconiti Lateralis Preparata, Fructus Mume etc., because its Skin peeling effect can cause skin injury, easily cause the pigmentation of skin thus increase the weight of symptom, should be cautious use of.

At present, most research is thought, chloasma is that melanocyte and melanosome all increase, and then show mottle due to patient with chloasma cutaneous lesion melanocyte increased activity.Under pathological state, intradermal macrophage can engulf the melanosome being dropped into corium, or calmness is in dermis, or at intracellular degradation, a part is through lymph metastasis.Generation and the excretion disequilibrium of pigment, and be gathered in the part in epidermis cell superfluously, just form pigmentation.Melanic excretion has two approach: one is drain in kidney, and another is discharged through skin, and namely melanin is transferred in keratoprotein, migrates to horny layer with epidermal growth, finally renews with the horny layer cycle and comes off.The method for the treatment of chloasma comprise acupuncture and tuina-massage (as local acupuncture, body acupuncture, acupoint injection therapy, cup, scrape therapy, massage, SHENQUE acupoint stick, sunken cord, imbedding needle, the ear acupoint etc.), external treatment (as cream, facial film, lotion, stifling side) and decoction for the treatment etc.Existing square medicated bag draws together XIAOYAO POWDER, JIAWEI XIAOYAO SAN, LIUWEI DIHUANG TANG, TAOHONG SIWU TANG, decoction for removing blood stasis, ERZHI WAN, GUIPI TANG etc.; The most frequently used Chinese medicine is followed successively by Radix Angelicae Sinensis, Poria, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Fructus Ligustri Lucidi, Radix Glycyrrhizae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Semen Persicae, Cortex Moutan, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Fructus Corni, Herba Leonuri, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Rhizoma Cyperi etc.But the effect of these Therapeutic Method is not very desirable, fundamentally can not treat chloasma, and also has certain side effect.Therefore, the medicine preventing and treating chloasma improving a kind of highly effective and safe has become the urgent needs of people.Prevalence is on the rise in recent years, gives much people's spirit of liking to be beautiful and in lifely cause great misery now.

Chloasma, butterfly spot belong to dermatology common disease, and pathogenesis it be not immediately clear.Modern medicine is thought may be relevant with many factors such as endocrine disturbance, heredity, D&C, some chronic disease, ultraviolet excessive radiation.Wherein endocrine disturbance is primary pathogenic factors.Namely pigmented spots can be multiple at first, tend to merge form not of uniform size, irregular patch, are symmetrically distributed in the face exposing and expose.The most outstanding with cheekbone portion, forehead, two cheeks, sometimes in butterfly wing, occasionally in upper lip.Clear-cut margin or in diffusivity, local NIP and squama.No conscious sympton, pigment can slightly change with factors such as season, Exposure to Sunlight, hormonal changes, does not often prolongedly move back, and a part is in point puerperium or can slowly disappear after withdrawing contraceptive.

About the treatment of butterfly spot, chloasma, Western medicine is cracking-off agent (as retinoic acid, salicylic acid), Donisolone, plumbous mercurial, oxidant or reducing agent (as hydroquinone, hydrogen peroxide) mainly, has side effect in various degree or causes some complication.Chinese medicine product then because of its draw materials natural, safety good, low side effect, documents and materials are abundant, clinical efficacy is good and enjoy favor.Theory of Chinese medical science is thought " have Zhu Neibi shape all outer ", and " vital organs of the human body 12 are through QI and blood, all up in face." to stop in butterfly spot, the generation of chloasma and human body depression of liver-QI, stagnation of blood stasis, caused by liver and kidney deficiency, insufficiency of vital energy and blood, expectorant are turbid etc. multiple because of Suo Youguan.Its pathogenesis or by depression of liver-QI, with the passing of time heat-transformation, fumigates and give birth in face; Or because of qi depression to blood stasis, battalion defends and becomes estranged, and stops up stagnant channels, ties and send out in face; Or because of Liver and kidney deficient, Chong and Ren channel disorder, asthenia of essence and blood, can not go up and flourish to form in face; Or be that insufficiency of the spleen mistake is good for, raw in phlegm-damp, turbid pathogen blocks and causes in face.It is clinical adopts the therapy approach such as treatment by oral administration of medicines, external treatment, acupuncture, massage more, lays particular emphasis on from liver,spleen,kidney and starts with, and it is disorderly to correct function, eliminates gas, the stasis of blood, expectorant, the pathological factor such as wet, hot.

Summary of the invention

Technical problem to be solved by this invention is, tune up part in the doctor trained in Western medicine about butterfly spot, chloasma and use hormone, it is main for improving endocrine; External treatment medicine, though clinical Western medicine has certain curative effect, but effect still owes satisfied, mainly cracking-off agent (as retinoic acid, salicylic acid), Donisolone, plumbous mercurial, oxidant or reducing agent (as hydroquinone, hydrogen peroxide), investigation mission outside the city or town for oral administration has side effect in various degree or causes some complication; And oral medicinal herb medicine has some curative effects, but higher at drug manufacture cost, and also manufacturing cycle is longer, and preparation method is loaded down with trivial details; External used medicine specific aim is poor, and individual dispenser can not fundamentally treat chloasma, butterfly spot; And also have certain side effect.Therefore, find a kind for the treatment of butterfly spot of highly effective and safe, urgent needs that the medicine of chloasma has become people.

For solving these technical barriers, the invention provides one and treat butterfly spot, the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, be made up of endo-medicine and external used medicine, in described endo-medicine, the parts by weight of various crude drug are: Radix Rhodiolae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Folium Rhododendri Simsii 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, 10 ~ 20 parts, Flos Carthami, Rhizoma Polygonati Odorati 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Margarita 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Herba Artemisiae Anomalae 10 ~ 20 parts,

In described external used medicine, the parts by weight of various crude drug are: Bombyx Batryticatus 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Flos Magnoliae 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Faeces Passeris 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Ampelopsis 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Margarita 10 ~ 20 parts, Flos Rosae Chinensis 10 ~ 20 parts.

Described treatment butterfly spot, the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, in endo-medicine described in it, the parts by weight of various crude drug can be: Radix Rhodiolae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Folium Rhododendri Simsii 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, 10 ~ 20 parts, Flos Carthami, Rhizoma Polygonati Odorati 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Fructus Mori 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Semen Plantaginis 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, the Radix Aucklandiae 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, Margarita 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Herba Artemisiae Anomalae 10 ~ 15 parts,

In described external used medicine, the parts by weight of various crude drug can be: Bombyx Batryticatus 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Flos Magnoliae 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Faeces Passeris 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Ampelopsis 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Oenotherae erythrosepalae 10 ~ 15 parts, Margarita 10 ~ 15 parts, Flos Rosae Chinensis 10 ~ 15 parts.

Described treatment butterfly spot, the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, in endo-medicine described in it, the parts by weight of various crude drug can also be: Radix Rhodiolae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Folium Rhododendri Simsii 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, 10 ~ 15 parts, Flos Carthami, Rhizoma Polygonati Odorati 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Margarita 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Herba Artemisiae Anomalae 10 ~ 20 parts,

In described external used medicine, the parts by weight of various crude drug can also be: Bombyx Batryticatus 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, Flos Magnoliae 10 ~ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Faeces Passeris 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Ampelopsis 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Margarita 10 ~ 20 parts, Flos Rosae Chinensis 10 ~ 20 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of speckle removing Chinese medicine composition of invigorating blood circulation for the treatment of butterfly spot, chloasma, and the dosage form of oral preparations described in it is tablet, and preparation method comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of components to be merged, be condensed into powder and be mixed into starch film-making.

In described step a, crude drug can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.32 extractum, stand for standby use, becomes component 1.

In described step b, the medicinal residues of the crude drug above-mentioned ethanol extraction can crossed add 10 times of water gagings, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, and then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.32 extractum, stand for standby use, becomes component 2.

In described step c, can by the merging of component 1 and component 2, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, after obtaining medicated powder drying, mixing starch makes tablet.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of speckle removing Chinese medicine composition of invigorating blood circulation for the treatment of butterfly spot, chloasma, and the dosage form of external preparation described in it is the preparation method of ointment, comprises the following steps:

A, get Radix Notoginseng, the Radix Angelicae Dahuricae, Faeces Passeris and Pseudobulbus Bletillae (Rhizoma Bletillae) steam method and distill, obtain crystallization, for subsequent use as component 1;

B, again medicinal residues and the surplus stock medicine after distillation is put into ethanol and soak, heat is extracted 2 times, and one-tenth paste is component 2;

C, above-mentioned two kinds of components merged, unguentum made by the Margarita powder mixing Cera Flava or the vaseline that add pulverizing.

In described step a, first Radix Notoginseng, the Radix Angelicae Dahuricae, Faeces Passeris and Pseudobulbus Bletillae (Rhizoma Bletillae) steam method can be distilled according to described number, obtain crystal, for subsequent use as component 1;

In described step b, the mixing of the medicinal residues after distillation surplus stock except Margarita can be got and add the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, concentrated solution is settled into extractum shape, stand for standby use, becomes component 2.

The Chinese medicine composition of described treatment butterfly spot, chloasma, the endo-medicine dosage form of compositions described in it can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution or injection; The external drug dosage forms of described compositions can be: face film agent, unguentum, spray, liniment, gauze agent and ointment.

When the present invention uses, water decoction can once-a-day, 15th be a course for the treatment of.When tablet, pill and capsule use, three times on the one, each 2 to 3 or ball; When face film agent uses, after cleaning face just before going to bed every night, smeared to chloasma place, one as a child washed.

The present invention, in line with the therapeutic rules for the treatment of must aim at the pathogenesis of disease, controls from gas, stasis of blood opinion, holds concurrently with tonify deficiency righting.By vital energy regualting and blood circulation-promoting, adjust smooth QI and blood, dredging the meridian, hold concurrently with nourishing the liver and kidney, make human body adjust to lastingly, the state that stable equilibrium between yin and yang, QI and blood are unobstructed.Thus reach spot-removing beautifying face, beautify the object of appearance.Oral administration and externally of the present invention with the use of, can accelerate to treat the depression of liver-QI butterfly spot, the chloasma that cause, control from gas, stasis of blood opinion, hold concurrently with tonify deficiency righting.By vital energy regualting and blood circulation-promoting, adjust smooth QI and blood, dredging the meridian, hold concurrently with nourishing the liver and kidney, make human body adjust to lastingly, the state that stable equilibrium between yin and yang, QI and blood are unobstructed.Thus reach spot-removing beautifying face, blood circulation promoting and blood stasis dispelling, beautify the object of appearance.Blood-activating and qi-promoting of the present invention, treating chloasma and acne.For chloasma, the acne of caused by energy stagnation and blood stasis.Butterfly spot.External blood stasis dispelling, dispel the wind speckle removing.Be applicable to stagnation of QI-blood, the chloasma butterfly spot caused by failure of skin and muscle to be nourished.Interior tune is supported outward, can be used for eliminating chloasma, butterfly spot.

Detailed description of the invention

The butterfly spot cause of disease it be unclear that, and is more common in women, and in blood, estrogen level height is main cause.Its morbidity is relevant with gestation, Long-term Oral contraceptive, menoxenia.Also the patients such as some female reproductive system illness, tuberculosis, cancer, chronic alcoholism, hepatopathys are seen.Daylight can impel morbidity.Male patient accounts for 10%, and having research to think, that male falls ill is relevant with heredity.Infringement is yellowish-brown or dark brown patch, and be often symmetrically distributed in cheekbone buccal, also can involve socket of the eye week, forehead, upper lip and nose, edge is generally more obvious.Without subjective symptom and general malaise.The mottle depth and season, Exposure to Sunlight, endocrine factors is relevant.Psychentonia, stays up late, and fatigue can increase the weight of skin lesion.According to yellowish-brown erythra, be more common in young and middle-aged women and predilection site can be made a definite diagnosis, need and freckle, riehl's melanosis, nevus fuscoceruleus ophthalmomaxillaris, naevus fuscocaerules zygomaticus is differentiated.Butterfly spot there is no satisfied therapy now.As found cause of disease person's removing as far as possible.The chloasma caused by contraceptive, should cut out, but not necessarily disappear in a short time.

Chloasma is a kind of metabolism of pigment abnormity dermatosis betiding face, and show as the yellowish-brown or light black patch of symmetry that facial area size does not wait, divide on skin, that comforts is not in the way.Primary disease men and women all can occur, more with women.Its pathomechanism is complicated, and endocrine disturbance, ultraviolet radiation, D&C, Nervous and Mental Factors etc. all can cause the generation of primary disease.Chloasma, butterfly spot with liver, kidney is relevant and lack of proper care after one's birth, dysfunction of the spleen in transportation, QI-blood failing to nourish upward in face, also raw brown patch.In a word, primary disease and liver,spleen,kidney three dirty, especially in close relations with liver.Chloasma has another name called chloasma, shows as dark complexion, dark, dusty face, face Shao-, chloasma hepaticum, the symptoms such as black speck of looking unfamiliar, affects patient's appearance, cause serious mental pressure to it for one is many because of property hyperpigmentary disorders.But the pathogenic factor of chloasma and complicated mechanism, wherein irritability stasis, kidney water (sun) deficiency and blood stasis internal resistance are its most common pattern of syndrome, are secondly spleen soil virtual loss.

Pathogen and pathology of tcm is analyzed: in the classical documents of the traditional Chinese medical science, have following discussion to the etiology and pathogenesis of primary disease." General Treatise on the Cause and Symptoms of Diseases " is said: " dark complexion person, or internal organs have phlegm retention, or skin is by ailment said due to cold or exposure, all makes qi and blood disorder, causes raw black.The vital organs of the human body 12 menses, all go up in face, the trip of husband's blood, all flourish the exterior and the interior.People or phlegm retention waterlogging possession, or space between skin and muscles wind-engaging hyperamization gas discord, puckery or turbid, can not be flourish in skin, therefore become raw black ".Golden Mirror of Medicine is said: " depressed by troubled thoughts, blood is weak not magnificent, and fiery dryness accumulated in the stomach and intestine is stagnant and be born on face, and women has it more." " surgery great achievement " say: " and chloasma is born in the face of woman more, weak not magnificent by blood, and fiery dryness accumulated in the stomach and intestine becomes, doubtful thing certainly caused by." " Waike Zhengzong, Orthodox Manual of External Diseases " say: " and chloasma person, water thanks to can not fire processed, blood are weak can not magnificent meat so that fiery dryness accumulated in the stomach and intestine spotting is black, and color is withered not damp." motherland's medical science thinks, this pathogenetic endogenous cause of ill with liver,spleen,kidney three is dirty and QI-blood circulation not normal in close relations, therefore treatment by oral administration of medicines internal organs many from liver spleen kidney by controlling, start with from nourshing blood and promoting blood circulation of regulating the flow of vital energy QI and blood is many; This pathogenetic exopathogenic factor is because of " space between skin and muscles wind-engaging hyperamization gas is got along well, puckery or turbid, can not be flourish in skin ", or " blood is weak not magnificent, and fiery dryness accumulated in the stomach and intestine becomes ", namely because blood deficiency or skin are supported by ailment said due to cold or exposure or not smooth the caused passages through which vital energy circulates mistake of QI-blood circulation.Therefore, external treatment should carry out prescription from the angle of promoting the circulation of blood wind dispelling of enriching blood.

Theory of Chinese medical science is thought " have Zhu Neibi shape all outer ", and " vital organs of the human body 12 are through QI and blood, all up in face." to stop in the generation of chloasma and human body depression of liver-QI, stagnation of blood stasis, caused by liver and kidney deficiency, insufficiency of vital energy and blood, expectorant are turbid etc. multiple because of Suo Youguan.Its pathogenesis or by depression of liver-QI, with the passing of time heat-transformation, fumigates and give birth in face; Or because of qi depression to blood stasis, battalion defends and becomes estranged, and stops up stagnant channels, ties and send out in face; Or because of Liver and kidney deficient, Chong and Ren channel disorder, asthenia of essence and blood, can not go up and flourish to form in face; Or be that insufficiency of the spleen mistake is good for, raw in phlegm-damp, turbid pathogen blocks and causes in face.It is clinical adopts the therapy approach such as treatment by oral administration of medicines, external treatment, acupuncture, massage more, lays particular emphasis on from liver,spleen,kidney and starts with, and it is disorderly to correct function, eliminates gas, the stasis of blood, expectorant, the pathological factor such as wet, hot.Conventional method for the treatment of has that dispersing the stagnated live-QI to relieve the stagnation of QI, vital energy regualting and blood circulation-promoting, nourishing the liver and kidney, soothing liver and strengthening spleen, warming YANG activating the spleen, dampness removing reduce phlegm, eliminating damp-heat etc.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body carry out work, QI-blood circulating regularly freely balances as expensive, if QI and blood is not smooth will produce blood stasis, blood stasis hinders in body, will cause the deterioration of qi-blood circulating further, cause more serious stasis of blood plug, therefore the traditional Chinese medical science take QI and blood as guiding principle, make it smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, beauty treatment of nourishing blood.Skin speckle basic in the stasis of blood, move back speckle must first blood stasis dispelling, blood stasis dispelling when invigorating blood circulation, invigorate blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood runs thereupon; Blood is keeping of gas, be so incensed that and quiet, depressed then blood clotting, the deficiency of vital energy then blood prostration, gas compel then blood walk.QI and blood and then all and.And regulate the flow of vital energy liver, QI invigorating at lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face and occur the mottle such as chloasma, freckle, even occur alopecia, alopecia areata.The present invention mainly identifies and corrects the principle treated according to Chinese medicine, collect many doctor chiefs, extensively adopts the strange medicine wonderful recipe in rich receipts area, skims the cream off milk; Based on Chinese medicine to pathogenetic understanding of facial colour spot and Therapeutic Principle, reference is Chinese medicine pharmacological research achievement at all times, the natural Chinese medicine of screening inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs lets out poison, promoting blood circulation to remove blood stasis, regulates the metabolism function of human body, improve blood circulation of human body and liver detoxification ability, and form through the clinical practice summary of long-term diagnosis and treatment case.

Primary disease is called " chloasma ", " chloasma hepaticum ", " dusty face " etc. by motherland's medical science.Occur in the classical documents of the traditional Chinese medical science due to primary disease, have following discussion to the etiology and pathogenesis of primary disease." General Treatise on the Cause and Symptoms of Diseases " is said: " dark complexion person, or internal organs have phlegm retention, or skin is by ailment said due to cold or exposure, all makes qi and blood disorder, causes raw black.The vital organs of the human body 12 menses, all go up in face, the trip of husband's blood, all flourish the exterior and the interior.People or phlegm retention waterlogging possession, or space between skin and muscles wind-engaging hyperamization gas discord, puckery or turbid, can not be flourish in skin, therefore become raw black ".Golden Mirror of Medicine is said: " depressed by troubled thoughts, blood is weak not magnificent, and fiery dryness accumulated in the stomach and intestine is stagnant and be born on face, and women has it more." " surgery great achievement " say: " and chloasma is born in the face of woman more, weak not magnificent by blood, and fiery dryness accumulated in the stomach and intestine becomes, doubtful thing certainly caused by." " Waike Zhengzong, Orthodox Manual of External Diseases " say: " and chloasma person, water thanks to can not fire processed, blood are weak can not magnificent meat so that fiery dryness accumulated in the stomach and intestine spotting is black, and color is withered not damp." motherland's medical science thinks; this pathogenetic endogenous cause of ill is with liver,spleen,kidney three is dirty and QI-blood circulation not normal in close relations; therefore treatment by oral administration of medicines is controlled from liver spleen kidney opinion internal organs are many, although be in the skin lesion on skin of face surface in gas chloasma, is also the external reflection of body interior dysequilibrium.So will from entirety in treatment, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Liver spleen essence and blood is full, punching appoints tune smooth, then the money of medicine carrying had by oneself by blood network.Liver controlling conveyance and dispersion, can adjust and reach QI and blood, happy feelings will.If depression of liver-QI, qi-blood disharmony. qi depression to blood stasis. stop up stagnant channels, on tie and then cause speckle in face.Liver storing blood.Liver blood fill and, then body be good for face profit.If deficiency of the liver and kindey, blood and essence asthenia, can not go up Rong Ze easily raw speckle.

The Radix Astragali, can invigorating QI to consolidate the body surface resistance based on tonify deficiency, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cave in for insufficiency of vital energy and blood, skin infection, difficulty in discharging of pus or burst for a long time and do not hold back person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and the immunologic function of energy enhancing body, therefore can also be used for the generation preventing some infectious disease." book on Chinese herbal medicine meets former " carries: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rush down YIN-fire, remove lung-heat, lossless, sends out, and has antiperspirant then to stop." be the good medicine promoting resistance and defence disease.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Rhizoma Chuanxiong is pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, is gynecological's common drug, has the effect of activating blood cirulation to regulate QI flow, but can not be multiplex, and especially health has the people of bleeding to be not suitable for taking, as female menstrual period.Meanwhile, Rhizoma Chuanxiong is again one of medical material conventional in medicated diet, with Gallus Domesticus with eating, can nourishing yin and activating blood, and be women's excellent tonic product.

Semen Persicae is bitter, sweet, puts down the special medicine for blood stasis blood closes.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicineization justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and body profit can grow dryness of the intestine.If gross weight grinds multiplex, walk Liver Channel, main broken blood-retention, water month by month, and pain all over, extremity wood numbness, left hemiplegia, left pain in foot notably, is relaxed through promoting the circulation of blood of invigorating blood circulation with it, there is the merit of eliminating blood stasis to promote regeneration of blood, if few use is mashed in peeling, enter large intestine, control blood depletion just to close, the dry dyschezia of blood, with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Energy main large migratory arthralgia, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out only.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.There is the function of clearing away heat and cooling blood, eliminating stasis to stop pain.Raw Radix Paeoniae Rubra wins with clearing away heat and cooling blood power.The fever of the body being used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases is hemorrhage, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Wine Radix Paeoniae Rubra: with promoting blood circulation to remove blood stasis power victory, clearing away heat and cooling blood effect is more weak.Be used for amenorrhea or dysmenorrhea, traumatic injury.Radix Paeoniae Rubra can purify the blood a point excess-heat, and dissipating blood stasis blood is detained.This product function is close with Cortex Moutan, therefore normal and Cortex Moutan mutual reinforcement between is for use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, can purify the blood a point excess-heat, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Rhizoma Polygonati Odorati: nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of calentura cloudy liquid consumption wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain.Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.Vitamin A contained in Rhizoma Polygonati Odorati, improves dry and cracked, rough skin situation, makes it soft lubrication.Play the effect of beauty and skin care." stem is tetanic, like bamboo arrow shaft, has joint for Collective Notes to the Canon of Materia medica cloud." therefore have the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine, and Chinese medicine name is also Rhizoma Polygonati Odorati, and autumn excavates, and cleans, shines to softness, repeatedly rub, and dry in the sun, to without hard-core, is dried, or steams thoroughly, rubs to translucent, dries, and cuts sheet or section use." book on Chinese herbal medicine justice ": " control lung dryness of the stomach heat, the diseases such as body fluid dries up, thirsty dry sensation in the pharynx, and excessiveness of stomach-fire, dry thirsty rapid digestion of food, polyorexia person, You Youjie is imitated ".

Fructus Mori nourishing YIN and benefiting blood medicine; Promote the production of body fluid medicine; Aperitive.To enrich blood YIN nourishing, promote the production of body fluid and moisturize.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science thinks the acid of Fructus Mori sweet in the mouth, and cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, the effects such as intestine moistening is dry, cure mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, xerostomia of quenching one's thirst, the diseases such as constipation with dry stool.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria.Herba Leonuri, containing the material such as leonurine, Fumaric acid, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, and often join the same use of Fructus Mori, fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.The protective effect research of liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, to rat skin lower injection, serum glutamic pyruvic transminase can be reduced, there is obvious protective effect to the hepatic injury of Carbon Tetrachloride Induced, and can liver cell regeneration be promoted. oleanolic acid also can make triglyceride accumulation minimizing in liver, hepatocellular degeneration necrosis obviously alleviates, glycogen accumulation increases, serum γglobulin declines; Ultrastructure visible hepatocyte mitochondrial swelling and endosomal vesicle degeneration alleviate, hepatic tissue interstitial inflammation habituation.

Radix Bupleuri clearind deficient heat Chinese medicine, comes off for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus, menoxenia.Return Liver Channel, gallbladder meridian.Function: evacuate and bring down a fever, yang invigorating soothing liver-QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Treatment viral hepatitis: injection of Radix Bupleuri (every lml is containing crude drug 2g) 10 ~ 20ml adds the quiet note of 50% Glucose Liquid or quiet of 5% Glucose Liquid 250 ~ 500ml, every day 1 time was for 10 times 1 course for the treatment of, treatment viral hepatitis 120 example, wherein acute case 97 example, effective percentage is 98.4%; Chronic cases 23 example, effective percentage is 100%, all has better effect to improving symptom, retraction liver spleen, recovery liver function and hepatitis B antigen negative conversion rate.

Radix Rhodiolae, Chinese medicine name.For the dry root welding technology of Crassulaceae Radix Rhodiolae, autumn scape withered after excavate, removing rough bark, clean, dry.Sweet in the mouth, hardship, property is put down, and returns lung, heart channel.There is benefiting QI for activating blood circulation, the merit of relievining asthma of promoting blood circulation.Be mainly used in blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted." Chinese medicine voluminous dictionary " is recorded: and Radix Rhodiolae " cold in nature, sweet-puckery flavor.Promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough.Control hemoptysis, spitting of blood, pneumonia is coughed.

This species Herb hyoscine of Folium Rhododendri Simsii: have promoting flow of QI and blood, tonify deficiency, treatment endogenous cough, nephrasthenia deafness, menoxenia, the diseases such as rheumatism.Flower (Cuculus polioephalus): sour, sweet, temperature.Invigorate blood circulation, regulating menstruation, wind-damp dispelling.For menoxenia, amenorrhea, metrorrhagia, traumatic injury, rheumatalgia, spits blood, epistaxis.Flower, fruit treatment menoxenia, amenorrhea, traumatic injury, rheumatalgia, spits blood, epistaxis; Rheumatic arthritis is treated in radical cure, traumatic injury, metrorrhagia, discharging fresh blood stool, amenorrhea " record of Yunnan medicine "

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Semen Plantaginis: clearing away heat and promoting diuresis, removing heat from blood, removing toxic substances.Cure mainly accumulation of heat in the urinary bladder, dysuria, stranguria with turbid discharge leukorrhagia, heat-damp in summer dysentery, epistaxis, hematuria, liver-heat conjunctival congestion, laryngopharynx swelling and pain, carbuncle sore tumefacting virus." not Lu ": " main incised wound, hemostasis, nosebleed nose, blood stasis, abdominal mass due to blood stasis, hematochezia, red urine.Only tired, the therapeutic method to keep the adverse QI flowing downwards, except small worm." Collective Notes to the Canon of Materia medica: " leaf smashes extracting juice clothes, treats and lets out essence." " property of medicine opinion ": " control hematuria.Energy tonifying five ZANG-organs, improving eyesight, diuresis, logical five types of stranguria." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " point sharp five types of stranguria, red white turbid urine, sealing rushes down, consumer edema, moves back eye red for clearing away stomach-heat, improving eyesight diuresis.

Fructus Gardeniae (formal name used at school: GardeniajasminoidesEllis) is called: Yellow Fructus Gardeniae, Fructus Gardeniae, white toad are the fruits of Maguireothamnus speciosus Fructus Gardeniae.The fruit of Fructus Gardeniae is Chinese medicine, and the l belonging to Ministry of Public Health promulgation criticizes medicine-food two-purpose resource, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.The diseases such as treatment icterohepatitis, bruise, hypertension, diabetes are usually used at tcm clinical practice.

Radix Aucklandiae circulation of qi promoting, pain relieving, spleen invigorating, helps digestion, and controls: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia; Middle gas is not economized; Sudden deafness; Snake bite and insect sting; Toothache." detailed outline ": the Radix Aucklandiae, is the medicine of three burnt edema caused by disorder of QI, can be elevated all gas.All gas Fen are strongly fragrant, all belong to lung, therefore the person of QI stagnating in upper-JIAO use, be golden Yu Ze let out also; Middle gas is not transported, and all belongs to spleen, therefore the person that QI stagnating in middle-JIAO is suitable, taste happiness fragrance is also; QI stagnation of the large intestine then weighs afterwards, and bladder gas does not change then infirmity pouring, and hepatic depression is then pain, therefore stagnation of QI in lower-JIAO person should it, the person that is plug logical also." book on Chinese herbal medicine converges and says ": Radix Aucklandiae (Radix Vladimiriae), total medicine of gas controlled in " book on Chinese herbal medicine " speech, easing stomach-QI, the logical motive, fall lung qi, dispersing liver-energy, fast temper, warming the kidney gas, removing food stagnancy gas, warm cold, along inverse gas, reach table gas, Tongli gas, the unified lower inside and outside all gas with it of pipe, solely pushes away its merit.Right nature and flavor are fragrant dry and violent, and as the deficiency of the lung has hot person, blood depletion rushing pulse person, the deficiency of YIN fire person of punching, the fiery person of heart stomachache genus, vigour collapse person, all diseases have latent heat person, carefully gently do not violate.

Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treatment scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

Ramulus Cinnamomi Chinese crude drug Ramulus Cinnamomi is the dry twig of Cortex Cinnamomi, generally gathers in spring, summer, directly dries or cuts into slices and dry after removing leaf.The pungent temperature of Ramulus Cinnamomi, can cold-dispelling, can treat cold, fever with chills etc.Its nature and flavor are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if menthocamphorate, rheumatism wet goods are all containing cassia oil composition.Function: Ramulus Cinnamomi energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Flos Albiziae contains Herba Albiziae glycoside, tannin, resolving stagnation for tranquilization, appetizing of regulating the flow of vital energy, activating collaterals to relieve pain, for irritability, melancholy insomnia.Control pent-up uncomfortable in chest, insomnia, forgetful, acute conjunctivitis, can settling five organs, and will, improving healthy complexion, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.Also have clearing away summer-heat, face-beautifying and spot-removing such as to relieve the effect of alcohol at the effect." herbal warp " is said: " Flos Albiziae energy settling five organs, and will, improving healthy complexion." especially to anemia of pregnant woman, have keep fit preferably, calm, the effect of calming the nerves, improve looks, be also treat neurasthenic good merchantable brand.

Herba Artemisiae Anomalae is the herb of feverfew artemisia anomalas, and it has hemostasis of curing the wound, and removing blood stasis stimulates the menstrual flow, promoting digestion and removing stagnation, the effect of appetizing of being amusing.It can be used for acute icterohepatitis, toothache, chronic tracheitis, stomatitis, pharyngolaryngitis, tonsillitis, nephritis, malaria; Eye conjunctivitis is controlled in external, otitis media, skin infection, eczema, traumatic hemorrhage.

The Margarita Pharmacopoeia of the People's Republic of China and " Chinese medicine voluminous dictionary " all indicate: Margarita has the effects such as arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, and modern study also shows that Margarita is improving the effect all in body immunity, slow down aging, freckle removing and whitening, supplement calcium etc. with uniqueness.To calm the nerves arresting convulsion, heat clearing away YIN nourishing, improving eyesight, removing toxic substances.Relieving palpitation is calmed the frightened, and is applicable to palpitation with fear palpitation with a distress feeling, epilepsy infantile convulsion.Liver heat removing removes nebula improving eyesight, with controlling the ophthalmic diseases such as conjunctival congestion and swelling pain, pterygium, and many externals.Convergence granulation promoting, is applicable to that throat rots, aphtha of the mouth and tongue, ulcer do not close up for a long time.

External used medicine has:

Radix Notoginseng sweet in the mouth; Micro-hardship; Warm in nature.Return Liver Channel; Stomach warp; Heart channel; Lung meridian; Large intestine channel.Radix Notoginseng [Panaxnotoginseng (BurK.) F.H.Chen] is araliaceae ginseng plant, it is Chinese distinctive rare Chinese medicine, one of Ye Shi China medicinal and edible plant the earliest, Radix Notoginseng is just acknowledged as since ancient times has significant blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain effect, has the good reputation of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) ", " southern part of the country SHENCAO ".Because branch divides three, be seven, therefore be called " Radix Notoginseng ", have another name called Radix Notoginseng, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) etc., ancient times is also known as clear ginseng, Herba Wedeliae Wallichii, Panax pseudoginseng, Typhonium flagelliforme (Lodd.) Blume, mountain paint, Radix Notoginseng etc.Excavating in season in winter in spring two because being everlasting, being divided into again " spring seven " and " winter seven ".Because Radix Notoginseng is all panax species, and its effective active matter higher than with more than Radix Ginseng, be therefore called " king in ginseng " by modern Chinese medicine medicine scholar again.Radix Notoginseng " promoting tissue regeneration by removing blood stasis ", modern study confirms that Radix Notoginseng has blood tonification effect.Irradiate mice through 60CO-gamma-rays, PNS abdominal cavity injects 6 days continuously, has obvious facilitation to the propagation of pluripotential hemopoietic stem cell, and in Spleen nodes, grain, red two is that cell mitogen enlivens, and spleen weight increases.Reduce the murine interleukin that cyclophosphamide causes, PNS also has promotion restitution.In rat acute hemorrhagic anemia, Radix Notoginseng injection significantly can promote the recovery of erythrocyte, reticulocyte, hemoglobin.Radix Notoginseng is the common medicine for the treatment of traumatic injury, has definite analgesic activity.Analgesic activity is had to multiple pain models such as mouse writhing method, hot plate method and rat light radiation tail-flick methods.Analgesic effective component is Panaxadiol saponin.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, repercussive blood, can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui, brings down a fever, relieving restlessness, QI invigorating, the capable hot disease in sky, pestilence miasma, mania and irritation, and married woman's blood is transported, and hemorrhoidal hamorrhage, rushes down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion exerts meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.Spit blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.Shennong's Herbal: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; Compendium of Material Medica: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping." Japan hanako materia medica ": control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Bombyx Batryticatus enters liver, lung, stomach warp.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis." herbal classic ": main pediatric epilepsy scared night cry, goes three worms, Mie Hei über, and the cloudy infections of man is sick." not Lu ": woman's metrorrhagia is in vain red, puerperal remaining pain, all skin ulcer cicatrixs of going out.Not it, envelope furuncle swell, root ought go out certainly." property of medicine opinion ": control locked mouth, diaphoresis, housewife people's metrorrhagia hematochezia is more than.

Flos Magnoliae is warm in nature, the micro-hardship of acrid in the mouth.Gui Jing attaches to the lung and stomach meridians.Dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge." herbal classic ": main the five internal organs health cold and heat, public attention headache, face acid anhydride." not Lu ": warming middle-JIAO expelling pathogenic factors from muscles, sharp nine orifices, stuffy nose relieving plug, tears go out, and control swelling of the face and draw toothache, and dizziness, body are several as person on car and boat.Raw beard and hair, removes tapeworm." property of medicine opinion ": can acid anhydride of looking unfamiliar be controlled.Face fat use, key light China.

Herba Asari, Chinese medicine name, cures mainly: dispel the wind, cold expelling, and row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.All herbal medicine, with being antipyretic, diuresis, analgesia, tranquilizer.Control headache, the effect of have diaphoresis, eliminating the phlegm.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; Phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.Refrigeration function Herba Asari volatile oil gavages has obvious refrigeration function to the rabbit experiment heat pyrexia of many reasons caused by Wen Cifa, tetrahydrochysene beta-naphthylamine, typhoid fever, paratyphoid fever mixed vaccine, also has obvious antipyretic response to the rat fever caused by beer yeast.The body temperature of normal rat can also be reduced.

Radix Ampelopsis returns through heart channel; Lung meridian; Liver Channel; Spleen channel.Function: heat-clearing and toxic substances removing; Removing obstruction for relieving pain; Promoting tissue regeneration and ulcer healing.Cure mainly: sore swollen toxin, scrofula, scald, eczema, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury, traumatic hemorrhage.Radix Ampelopsis is the root of vitaceae Radix Ampelopsis, and annual spring, autumn excavate, and removing stem and thin fibrous root, after cleaning, many rip cuttings become two lobes, pintongs or inclined tab, dry and can be used as medicine.It is cool in nature, and bitter but sweet flavor is pungent, has effect of heat clearing away, removing toxic substances, eliminating stagnation, granulation promoting, pain relieving, is used for the treatment of the diseases such as carbuncle, furuncle, scrofula, scald, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula

Radix Oenotherae erythrosepalae Chinese medicine name.For Oenotheraceae Radix Oenotherae erythrosepalae OenotheraerythrosepalaBorb., be used as medicine with root.It is the most important nutrient drug found this century.Can treat various diseases, regulate lipid material in blood, the diseases such as the coronary ligation caused hypercholesterolemia, hyperlipidemia, atherosis and cerebral thrombosis have significant curative effect.Treat aching and limp, promoting blood circulation to remove obstruction in the collateral; Endogenous wind stopping suppressing the hyperactive liver; Detumescence sore.Main obstruction of qi in the chest and cardialgia; Apoplectic hemiplegia; Stirring-up of pathogenic wind in the interior resulting from deficiency; Children's moves more; Wind dampness rheumatic anesthesia pain; Stomachache is had loose bowels; Dysmenorrhea; Oral-anal-genital ulcer syndrome; Skin infection; Eczema.

Flos Rosae Chinensis, Chinese medicine name.For the dried floral of rosaceous plant Chinese rose RosachinensisJacq..The whole year all can gather, and plucks, dry in the shade or cold drying when spending crack.Be cultivation.There is promoting blood flow to regulate menstruation, effect of dispersing the stagnated live-QI to relieve the stagnation of QI.Be usually used in qi depression to blood stasis, menoxenia, dysmenorrhea, amenorrhea, distending pain in the chest and hypochondrium.

Cortex Moutan, has another name called Cortex Moutan, Chinese medicine name.For the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn excavates root, and removing radicula, strips root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.

Radix Angelicae Pubescentis, Chinese medicine name.For the dry root of samphire Angelica pubescens.Main product in Sichuan, Hubei, the ground such as Anhui.At the beginning of spring or autumn end excavate, removing fibrous root and silt, a heatable brick bed, to half-dried, is banked up 2 ~ 3 days, after feeling like jelly again a heatable brick bed to absolutely dry.Section, raw use." book on Chinese herbal medicine just ": " specially reason part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness, pruritus due to damp pathogen contracture." modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation; And it is not have hypotensive effect, but lasting; Contained bergapten, xanthotoxin etc. have photosensitive and antitumor action.

Faeces Passeris: enter liver, kidney two warp.Function cures mainly eliminate indigestion, removing nebula.Control hernia abdominal mass, disease addiction, corneal nebula, bulbar conjunctiva polyp, dental caries.Treat ophthalmalgia, certainly carbuncle furuncle, woman's leukorrhagia, drown unfavorable, except hernia abdominal mass." daily book on Chinese herbal medicine ": " remove freckle on face, whelk.”

Specific embodiment 1

The preparation of honey pill agent of the present invention: by Radix Rhodiolae 1500g, Radix Angelicae Sinensis 1500g, Folium Rhododendri Simsii 1500g, Rhizoma Chuanxiong 1500g, Radix Astragali 1500g, Semen Persicae 1500g, Flos Carthami 1500g, Rhizoma Polygonati Odorati 1500g, Fructus Gardeniae 1500g, Radix Polygoni Multiflori Preparata 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Paeoniae Rubra 1500g, Fructus Mori 1500g, Herba Leonuri 1500g, Semen Plantaginis 1500g, Fructus Ligustri Lucidi 1500g, Radix Aucklandiae 1500g, Radix Bupleuri 1500g, Margarita 1500g, Ramulus Cinnamomi 1500g, Flos Albiziae 1500g, Herba Artemisiae Anomalae 1500g, soak, heated and boiled 3 times, each 1-2 hour, filter, filtrate is for subsequent use; To merge in the filtrate suction concentrating under reduced pressure tank of latter 3 times, being evaporated to relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C; Put into baking oven, put into baking oven, control at 75 DEG C, be cooled to after oven dry Powdered be mixed in Mel together be twisted into slice; With every 5g be one ball wax seal packaging.

Specific embodiment 2

The manufacturing process of capsule of the present invention is: get Radix Rhodiolae 1200g, Radix Angelicae Sinensis 1200g, Folium Rhododendri Simsii 1200g, Rhizoma Chuanxiong 1200g, Radix Astragali 1200g, Semen Persicae 1200g, Flos Carthami 1200g, Rhizoma Polygonati Odorati 1200g, Fructus Gardeniae 1200g, Radix Polygoni Multiflori Preparata 1200g, Rhizoma Atractylodis Macrocephalae 1200g, Radix Paeoniae Rubra 1200g, Fructus Mori 1200g, Herba Leonuri 1200g, Semen Plantaginis 1200g, Fructus Ligustri Lucidi 1200g, Radix Aucklandiae 1200g, Radix Bupleuri 1200g, Margarita 1200g, Ramulus Cinnamomi 1200g, Flos Albiziae 1200g, Herba Artemisiae Anomalae 1200g, get crude drug to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, stand for standby use, become component 1.The medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times of water gagings, heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill, become component 2.By the merging of component 1 and component 2, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate is after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, incapsulate after obtaining medicated powder drying.

Specific embodiment 3

By described crude drug Radix Rhodiolae 1300g, Radix Angelicae Sinensis 1300g, Folium Rhododendri Simsii 1300g, Rhizoma Chuanxiong 1300g, Radix Astragali 1300g, Semen Persicae 1300g, Flos Carthami 1300g, Rhizoma Polygonati Odorati 1300g, Fructus Gardeniae 1300g, Radix Polygoni Multiflori Preparata 1300g, Rhizoma Atractylodis Macrocephalae 1300g, Radix Paeoniae Rubra 1300g, Fructus Mori 1300g, Herba Leonuri 1300g, Semen Plantaginis 1300g, Fructus Ligustri Lucidi 1300g, Radix Aucklandiae 1300g, Radix Bupleuri 1300g, Margarita 1300g, Ramulus Cinnamomi 1300g, Flos Albiziae 1300g, Herba Artemisiae Anomalae 1300g, dries, and is ground into granule, soaks 1 hour; Soaked raw material is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds the water of total amount 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount, and after convection drying powdered, dissolved granule made by mediation Mel or dextrin.

Specific embodiment 4

The preparation method of Tablets: get crude drug Radix Rhodiolae 1200g, Radix Angelicae Sinensis 1300g, Folium Rhododendri Simsii 1200g, Rhizoma Chuanxiong 1300g, Radix Astragali 1300g, Semen Persicae 1300g, Flos Carthami 1200g, Rhizoma Polygonati Odorati 1200g, Fructus Gardeniae 1300g, Radix Polygoni Multiflori Preparata 1300g, Rhizoma Atractylodis Macrocephalae 1100g, Radix Paeoniae Rubra 1300g, Fructus Mori 1300g, Herba Leonuri 1300g, Semen Plantaginis 1300g, Fructus Ligustri Lucidi 1200g, Radix Aucklandiae 1100g, Radix Bupleuri 1300g, Margarita 1300g, Ramulus Cinnamomi 1300g, Flos Albiziae 1300g, Herba Artemisiae Anomalae 1300g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.32 extractum, stand for standby use, become component 1, the medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times of water gagings, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.32 extractum, stand for standby use, becomes component 2.By the merging of component 1 and component 2, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, after obtaining medicated powder drying, mixing starch makes tablet.

Specific embodiment 5

The manufacturing process of external face film agent of the present invention is: first Radix Notoginseng 1500g, Radix Angelicae Dahuricae 1500g, Faeces Passeris 1500g and Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g steam method are distilled according to described number, obtain crystal, for subsequent use as component 1, get the medicinal residues mixing surplus stock Bombyx Batryticatus 1500g after distillation, Cortex Moutan 1500g, Herba Asari 1500g Flos Magnoliae 1500g, Radix Ampelopsis 1500g, Radix Angelicae Pubescentis 1500g, Radix Trichosanthis 1500g, Radix Oenotherae erythrosepalae 1500g, Flos Rosae Chinensis 1500g, add the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 2, the component 1 of distillation extraction and the component 2 of ethanol extraction are mixed, add and pulverize Margarita 1500g, mixing Cera Flava becomes facial film, bottles after ultraviolet sterilization.

Specific embodiment 6

The preparation method of externally used paste of the present invention comprises: according to described number first by Radix Notoginseng 1200g, and Radix Angelicae Dahuricae 1200g, Faeces Passeris 1200g and Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g steam method distills, and obtains crystal, for subsequent use as component 1, get the medicinal residues mixing surplus stock Bombyx Batryticatus 1200g after distillation, Cortex Moutan 1200g, Flos Magnoliae 1200g, Radix Ampelopsis 1200g, Radix Angelicae Pubescentis 1200g, Radix Trichosanthis 1200g, Radix Oenotherae erythrosepalae 1200g, Flos Rosae Chinensis 1200g, add the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 2, the component 1 of distillation extraction and the component 2 of ethanol extraction are mixed, adds the Margarita powder 1200g of pulverizing, mixing vaseline or Cera Flava paste making agent.

Pharmacological toxicity is tested

Embodiment 1: acute toxicity testing

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Experiment thing: granule is taken in the present invention orally.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: long term toxicity test data

The present invention takes the decoction agent of granule orally through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, often organize 30, male and female half and half (be divided into high, medium and low three dosage groups, often organize 10), wherein first group through gavage to normal saline; Be 0.25g, 2.5g and 12.5g/kg.d to dosage of the present invention through gavage for second group; 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, observe the evaluation that the indexs such as the clinical manifestation after each treated animal administration, hematology, blood biochemistry, organ coefficient and histopathology carry out drug toxicity respectively.Result of study: the present lovastatin 50mg/kg.d of major toxicity reaction table and 5.0mg group, shows SD rat upon administration and has occurred reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step, total food ration and losing weight; Blood test display total white blood cells increases to some extent, and Erythrocytes, content of hemoglobin and platelet count obviously decline (the equal < 0.05 of P); Blood biochemistry checking display ALT, AST, ALP and CK raise 1 ~ 8 times (the equal < 0.05 of P), and creatinine and blood urea nitrogen raise to some extent (the equal < 0.05 of P), but do not cause animal dead; There is the Liver and kidney pathological change similar to people in histopathological analysis result display lovastatin 50mg/kg.d group.And all there is not similar reaction in normal saline group and 0.25g, 2.5g and 12.5g/kg.d of the present invention tri-dosage groups and lovastatin 0.5mg/kg.d dosage group during whole administration, at convalescent period viewing duration, occur that the symptom of each treated animal of reaction fades away recovery normal condition.Visible the present invention not only can reduce the toxic and side effects of lovastatin, and the clinical non-toxic of lovastatin can be made to be increased to 5 ~ 25 times (the equal < 0.01 of P).

Test example 3: cumulative toxicity is tested:

The present invention decocts agent to mice by 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation oral capsule of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Embodiment 4: skin irritation test

One, experimental technique

Depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory returns cage to observe 24 hours, often organizes Cavia porcellus and is coated with externally used paste 4,8 of the present invention and 12g respectively, and respectively containing crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

Two, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.Result is pointed out, and the present invention, without local irritant effect, also has no general toxicity performance.Show external preparation use safety of the present invention.

Pharmacological experiment illustrates:

1 material

1.1 animals: healthy 3 monthly age pure lines Kunming kind female mice 60, body weight 25 ~ 35g, the laboratory animal department of the Chinese Academy of Sciences of Shandong University provides.Animal feeding condition: often organize mice by group sub-cage rearing.When natural conditions are identical, routine raises food drinking-water, keeps natural lighting, without undesirable element impact, raises after within 1 week, adapting to experimental situation and starts to test,

1.2 experimental drugs: oral capsule of the present invention, by the preparation of embodiment 2 method, concentration: 0.12mg/ml, Pharmacy department of the court produces.3% Hydrochinone Cream: Pharmacy department of Wuhan Hospital of Traditional Chinese Medicine produces, lot number 20050905.Progesterone injection: Zhejiang Province XianJu Pharmacy stock Co., Ltd, lot number: 20050115.

1.3 reagent: sodium sulfide (NaS): the limited public affairs of extra large Ling Feng chemical reagent can, lot number: 20020118, is made into 10% aqueous solution before use.Superoxide dismutase (SOD), malonaldehyde (MDA) test kit: Bioengineering Research Institute is built up in Nanjing, lot number: 20059116.

1.4 key instruments: DY89-II type electric driven glass refiner: Xin Lan biotech inc, Ningbo.System biological microscope: OLYMPUS; BX50F4 Beijing Institute of Aeronautics Pathologic image analysis system.

2 experimental techniques

2.1 modellings: with reference to chloasma experimental animal model clone method.After the anesthesia of mice 2.5% pentobarbital sodium, the progesterone injection with 0.4% presses the intramuscular injection of 0.02g/kg dosage mouse hind leg, 6 times weekly, continuous 4 weeks.Normal group presses 0.02g/kg intramuscular injection sterilized water for injection.

2.2 animal grouping and administrations: get Healthy female mice 60,3 dosage groups, are divided into 6 groups at random, often organize 10.Normal group, model group, capsule of the present invention 3 dosage groups (0.15,0.3,0.6mg/m1), 3% hydroquinone positive controls (0.6mg/m1).The present invention's 3 dosage treatment groups respectively in mice modeling medication on the same day, every day 2 times, 6 times weekly, continuous use 30 days.Normal group and model group give distilled water in the corresponding time; 3% hydroquinone positive drug control group started local application in modeling the same day, and time and the course for the treatment of are with spot-removing beautifying face oral liquid treatment group.

2.3 observation index and detection: medication is after 30 days, and cervical dislocation puts to death mice, back unhairing, get rapidly each 2 pieces of the skin histology at hepatic tissue and coating position, wherein one piece with ice-cold normal saline flushing, removing blood, and filter paper blots, cut liver and each 0.5g of skin, put into the beaker of the pre-cold saline of 2.0ml respectively, shred tissue, then pour in test tube, with high speed disperser 10r/min homogenate twice, each 10 seconds; With 3500r/min rotating speed centrifugal 15 minutes again, get supernatant.Adopt xanthine oxidase, detect description method by test kit and measure SOD; Adopt thiobarbituricacidα-method, detect description method by test kit and measure MDA value.Meanwhile, separating mouse skin of back, get plucked skin histology one piece (about 2cm*1cm), 10% paraformaldehyde is fixed, routine paraffin wax embeds, section, and HE dyes, routine histopathologic detects, om observation, counting epithelial proliferation, dermal vascular number and chorionitis cell number; Immunohistochemical staining, (positive cell: nothing, counts 0 point for the dyeing of observation melanocyte and number; < 15%, counts 0.5 point, < 30%, counts 1 point; > 30% 2 points).

2.4 statistical methods: compare t inspection between measurement data employing group; Layered method data adopts rank test to carry out statistical disposition.

3 results

3.1 respectively organize mouse skin, hepatic tissue MDA, SOD content mensuration in table 1.

The mensuration (-x ± s) of mouse skin and hepatic tissue MDA, SOD content respectively organized by table 1

* P < 0.05.**P < 0.01 is compared with model group; #**P < 0.05 is compared with positive group

3.2 respectively group mouse skin Pathomorphologics and immunohistochemistry views PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM visible: the epithelial layer cell arrangement of normal group mouse skin is neat, and without hypertrophy, have no thin vessels in skin corium and expand, inflammatory cell is rare.The epithelial layer hyperplasia of model group mouse skin is obvious, and the large and arrangement disorder of core, visible thin vessels expansion in skin corium, inflammatory cell is common.The epithelial layer hyperplasia of dosage group big or middle and positive controls mouse skin alleviates to some extent, and arrangement disorder alleviates, and in skin corium, thin vessels expansion alleviates, and inflammatory cell is rare.The results are shown in Table 2.

Immunohistochemical PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM is visible: visible a little melanocyte in normal group mouse epithelial layer, the painted sepia of endochylema.Visible a large amount of melanocyte in model group mouse epithelial layer, the painted dark brown of endochylema, and positive cell number > 30%.Visible black color element cell in dosage group big or middle and positive controls mouse epithelial layer, the painted dark brown of endochylema, positive cell number reduces, in table 2.

Table 2 is group mice skin tissue pathomorphology and melanocyte observed result (n) respectively

Rank test; * P < 0.05, * * P < 0.01 is compared with model group

4, the microcirculation experimental technique of topical agent:

4.1 materials and methods: get 50 mices, be divided into 5 groups at random, often organize 10 (male and female half and half), and it is a little that matched group every Mus auris dextra is coated with normal saline; Positive controls every Mus auris dextra gives the white speckle dispelling ointment of commercially available silk (production of Nanjing Pharmaceutical), test component is dosage group 600mg/kg/h in externally used paste low dose group 400mg/kg/h of the present invention, externally used paste of the present invention, externally used paste high dose 800mg/kg/h of the present invention.15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, subsequently tail vein injection 0.1% epinephrine 0.1mL/10g, observes mouse right ear fine motion vein bore (μm) and 0.2mm immediately ²blood capillary net number .t checks process experimental data.

4.2 results and discussion

4.2.1. on microcirculatory impact

Compared with matched group, tested group 1 pair mice capillary open number has showed increased (P < 0.01); Tested group of 2 pairs of venule bores and capillary open number have remarkable increase (P < 0.01); Tested group of 3 pairs of mice fine motions, vein bore and capillary open number all have increase (P < 0.01); Illustrate and be subject to reagent to improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).

Table 3, externally used paste of the present invention are on the impact of mice fine motion, vein bore and capillary open number

4 discuss

The chloasma traditional Chinese medical science is called " chloasma hepaticum ", belongs to motherland's medical science " dark speckle " or " dusty face " category.It is generally acknowledged that primary disease occurs with liver,spleen,kidney three dirty in close relations.

Theory of Chinese medical science is thought " lung governing skin and hair ", as " Plain Questions " six saves state of internal organs opinion cloud: also, its Hua Mao, it fills at skin, points out that lung closes fur at body for lung person, the dominator of QI, the position of storing soul.When the function of lung is normal, lung yin fills, and normal lung-QI is peaceful, and body fluid is sufficient, and ability compress must be capable, and skin metabolism product is excreted, and makes skin clean, naturally shines gloss.Therefore have many doctors from ancient times to the present, recipe has and controls from lung opinion, we think that relevant, that people is corresponding to the world theory of Chinese medicine color effect is one of characteristic of Chinese therapeutics, and lung governing skin and hair is corresponding with white, the rule of this our prescription just.

Chloasma, chloasma hepaticum are a kind of dyskinetic dermatosis of metabolism of pigment being common in face, and be apt to occur in female middle-aged, its cause of disease and pathogeny are illustrated not yet completely.It is generally acknowledged morbidity and the endocrine disturbance of chloasma, ultraviolet radiation, inherited genetic factors is relevant.But research is in recent years thought, the generation of chloasma, chloasma hepaticum also changes relevant with oxygen-derived free radicals.Under normal physiological conditions, free radical constantly produces, but is also constantly eliminated, and makes it to be in a kind of dynamic equilibrium.And chloasma, chloasma hepaticum patient lipid peroxide (LPO) or Free Radical Level increases time, or antioxidase is as declines such as superoxide dismutase (SOD), catalase (CAT), glutathion (CSH) in body, the oxidation products such as lipid peroxide can not be removed in time, LPO is piled up in vivo.Thus accelerate the reaction of tyrosine series of oxidation.Blackening pigment cell produces melanin and increases; Its product malonaldehyde (MDA) of LPO extremely unstable can cause protein molecule to occur to be cross-linked simultaneously, forms fluorescent chromophore-pigment.

Thus point out the present invention can scavenging activated oxygen and reduce free radical produce; Pathologic examination shows it can obviously improve histiocytic pathological change, alleviates epithelial hyperplasia, alleviates the expansion of skin corium thin vessels, reduces inflammatory cell number; SABC detection display its obviously can reduce melanin positive cell number and optical density in epithelial layer.Show that the present invention has freckle removing and whitening effect.

Clinical data:

The warp of butterfly spot, chloasma and women, band, tire, product and feelings will are in close relations, therefore female middle-aged patient is comparatively common clinically.For reaching comparatively ideal therapeutic effect, take multiple method from Chinese medicine aspect, the combination of inner and outside, to reach treating both the principal and secondary aspects of a disease.Chloasma is also known as butterfly spot or cyasma, it is a kind of common facial pigmentation proliferative skin disorders, be in body disease at a kind of outward manifestation of face, with be everlasting cheekbone buccal symmetrically property distribution filbert or brown spot and name, part can betide around forehead, nose side and lip, a kind of damage capacitive dermatosis chronic disease blood-activating and qi-promoting of the present invention, treating chloasma and acne.For chloasma, the acne of caused by energy stagnation and blood stasis.Butterfly spot.External blood stasis dispelling, dispel the wind speckle removing.Be applicable to stagnation of QI-blood, the chloasma butterfly spot caused by failure of skin and muscle to be nourished.Interior tune is supported outward, can be used for eliminating chloasma, butterfly spot.Now be described below.

1 data and method

1.1 physical data

This group case is totally 40 examples, is women, 22 ~ 37 years old 17 age example; 37 ~ 45 years old 15 examples; More than 46 years old 8 examples.The course of disease is the shortest 3 months, reaches 10 years most.

1.2 clinical symptoms

Erythra show as differ in size, come in every shape, patch that the depth is indefinite, have and be dispersed in, merge in flakes or strip.Mainly be distributed in buccal both sides or mouth week or forehead.Skin lesion boundary is clear, and not swelling, nothing come off, and smooth surface, is not in the way.

1.3 method

1.3.1 side for oral administration is that key agents is: Radix Rhodiolae 11g, Radix Angelicae Sinensis 12g, Folium Rhododendri Simsii 11g from intending, Rhizoma Chuanxiong 12g, Radix Astragali 11g, Semen Persicae 12g, Flos Carthami 11g, Rhizoma Polygonati Odorati 12g, Fructus Gardeniae 11g. Radix Polygoni Multiflori Preparata 12g, Rhizoma Atractylodis Macrocephalae 11g, Radix Paeoniae Rubra 12g, Fructus Mori 11g, Herba Leonuri 12g, Semen Plantaginis 11g, Fructus Ligustri Lucidi 12g, Radix Aucklandiae 11g, Radix Bupleuri 12g, Margarita 11g, Ramulus Cinnamomi 12g, Flos Albiziae 11g, Herba Artemisiae Anomalae 12g. every day 1 dose, be decocted in water for oral dose.Also can be made into pill or granule, capsule.

1.3.2 external side: Bombyx Batryticatus 14g, Cortex Moutan 15, Radix Notoginseng 14g, Flos Magnoliae 15g, Pseudobulbus Bletillae (Rhizoma Bletillae) 14g, Faeces Passeris 15g, Herba Asari 14g, Radix Ampelopsis 15g, Radix Angelicae Pubescentis 14g, Radix Trichosanthis 15g, Radix Angelicae Dahuricae 14g, Radix Oenotherae erythrosepalae 15g, Margarita 14g, Flos Rosae Chinensis 15g makes face film agent.This side has the effect of benefiting QI for activating blood circulation, face-beautifying and spot-removing.

1.3.3 the main acupuncture point of acupoint massage is coordinated to be the sun, yang white, Zanzhu, Baihui, Yingxiang, Sibai, ShiShimonoseki, dicang, cheek car, cheekbone Liao etc.Massage manipulation adopts the maneuver of Chinese and western combination, and wherein Chinese style maneuver is based on acupoint massage, and Western-style maneuver is to pacify massage, lympha toxin expelling.

The method treatment in every 2 days 1 time 1 month was 1 course for the treatment of, and all the other carry out the moisturizing of skin of face, sun-proof, isolation every day time.

2 results

In 40 routine patients, recovery from illness, speckle disappears 25 examples entirely, accounts for 62.5%, effectively (skin lesion disappearances) 14 example, and account for 23.33%, invalid (raw hide damages and slightly improves) 1 is routine, and account for 2.5%, total effective rate is 97.5%.

3 discuss

The traditional Chinese medical science is thought, butterfly spot, chloasma are more common in and are educated menstrual woman, this aged women due to cause, housework busy, breed loss, many depression of liver-QI, stagnation of liver-QI is blood stasis then in addition.Golden Mirror of Medicine is said, and " be worried depressed, blood is weak not magnificent, and fiery dryness accumulated in the stomach and intestine is stagnant and be born on face, and women has it more." therefore I am based on SIWU TANG, enrich blood and invigorate blood circulation, help the medicine with dispersing the stagnated live-QI to relieve the stagnation of QI.Women's major part pressure of this age level is excessive, the impetuous irritability of disposition, and ZHU Dan-xi is said: through water person, also, the moon must from sun, therefore its color is red for cloudy blood .... through joining for gas, go because of gas, in bulk person is solidifying, will go and pain person's gas stagnant, the person of having a pain after row, also, also, reversed menstruation person gas is disorderly for the light also void of color for all void of QI and blood, purple person's gas stagnant, black then heat very also.The store blood of liver, main catharsis.Irritability is not dredged, disorder of movement of QI, qi depression to blood stasis, and kidney is the congenital foundation, and what punching was appointed is originally kidney, and collaterals of the uterus lies in kidney, and directly impact punching of suffering from a deficiency of the kidney is appointed, disharmony of Chong and Conception Channels, and qi depression to blood stasis is not smooth through water running.And the vital organs of the human body, the gas of extraordinary Fu-organ all can be gone up all in face, outside being revealed in, gradually in piebaldism.Radix Angelicae Sinensis with hemopoietic, the Radix Rehmanniae to grow blood, Radix Paeoniae yin fluid astringing, the logical gas up and down and in promoting the circulation of blood of Rhizoma Chuanxiong.Assistant is with Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, and Ramulus Cinnamomi can harmonizing yingfen and weifen, warm promoting blood circulation." " Yizong Jinjian surgery heart method " cloud: " and as in dirt dark, former in troubled thoughts depressed become ", stagnation of liver-QI blood stasis, strongly fragrant and fire-transformation, helps with Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, Fructus Gardeniae pathogenic fire purging relieving restlessness.

On the basis of endo-medicine, use face mask of traditional Chinese medicine external, except directly improving facial blood circulation, with the Chinese medicine such as the Radix Angelicae Dahuricae, Bombyx Batryticatus blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing.Give face mask of traditional Chinese medicine and directly act on skin, make it to absorb and reach the object of external treatment.Modern medicine study shows: tryrosinase is catalyst important in melanocyte production process, suppresses its activity then can control the generation of melanocyte, and the Pseudobulbus Bletillae (Rhizoma Bletillae) can the effect of restraint of tyrosinase and the enzymatic reaction of participation thereof; In addition, according to herbal pharmacology effect, the Radix Angelicae Dahuricae has antityrosinase active, stops oxidizing tyrosine to form pigment thus the effect having skin care crease-resistant.In addition the maneuver such as ionspray, massage can blood circulation promoting, expansion blood capillary, accelerate the infiltration of medicine and absorption, thus reach brighten, the effect of speckle dispelling.

Along with the development of society, increasing and the lack of standardization use of cosmetics, the pollution of atmospheric environment, chloasma sickness rate rises year by year, cosmetics lead, hydrargyrum, hormone severe overweight, these type of cosmetics are used to be as good as " drinking poison to quench thirst ", Chinese traditional treatment chloasma, butterfly spot origin stream are long, by the Chinese medicine of the traditional Chinese medical science, make drug and nutriment matter when skin temperature raises, accelerate infiltration and absorb, thus reach perfect therapeutic effect.Blood-activating and qi-promoting of the present invention, treating chloasma and acne.For chloasma, the acne of caused by energy stagnation and blood stasis.Butterfly spot.External blood stasis dispelling, dispel the wind speckle removing.Be applicable to stagnation of QI-blood, the chloasma butterfly spot caused by failure of skin and muscle to be nourished.Interior tune is supported outward, can be used for eliminating chloasma, butterfly spot.

Claims (10)

1. a treatment butterfly spot, the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, it is characterized in that, be made up of endo-medicine and external used medicine, in described endo-medicine, the parts by weight of various crude drug are: Radix Rhodiolae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Folium Rhododendri Simsii 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, 10 ~ 20 parts, Flos Carthami, Rhizoma Polygonati Odorati 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Margarita 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Herba Artemisiae Anomalae 10 ~ 20 parts,

In described external used medicine, the parts by weight of various crude drug are: Bombyx Batryticatus 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Flos Magnoliae 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Faeces Passeris 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Ampelopsis 10 ~ 20 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Margarita 10 ~ 20 parts, Flos Rosae Chinensis 10 ~ 20 parts.

2. treat butterfly spot according to claim 1, the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, it is characterized in that, in described endo-medicine, the parts by weight of various crude drug are: Radix Rhodiolae 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Folium Rhododendri Simsii 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, 10 ~ 20 parts, Flos Carthami, Rhizoma Polygonati Odorati 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Radix Paeoniae Rubra 10 ~ 15 parts, Fructus Mori 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Semen Plantaginis 10 ~ 15 parts, Fructus Ligustri Lucidi 10 ~ 15 parts, the Radix Aucklandiae 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, Margarita 10 ~ 15 parts, Ramulus Cinnamomi 10 ~ 15 parts, Flos Albiziae 10 ~ 15 parts, Herba Artemisiae Anomalae 10 ~ 15 parts,

In described external used medicine, the parts by weight of various crude drug are: Bombyx Batryticatus 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts, Radix Notoginseng 10 ~ 20 parts, Flos Magnoliae 10 ~ 20 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 20 parts, Faeces Passeris 10 ~ 20 parts, Herba Asari 10 ~ 20 parts, Radix Ampelopsis 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, the Radix Angelicae Dahuricae 10 ~ 15 parts, Radix Oenotherae erythrosepalae 10 ~ 15 parts, Margarita 10 ~ 15 parts, Flos Rosae Chinensis 10 ~ 15 parts.

3. treat butterfly spot according to claim 1, the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, it is characterized in that, in described endo-medicine, the parts by weight of various crude drug are: Radix Rhodiolae 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Folium Rhododendri Simsii 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, 10 ~ 15 parts, Flos Carthami, Rhizoma Polygonati Odorati 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Radix Paeoniae Rubra 10 ~ 20 parts, Fructus Mori 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Ligustri Lucidi 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, Margarita 10 ~ 20 parts, Ramulus Cinnamomi 10 ~ 20 parts, Flos Albiziae 10 ~ 20 parts, Herba Artemisiae Anomalae 10 ~ 20 parts,

In described external used medicine, the parts by weight of various crude drug are: Bombyx Batryticatus 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts, Radix Notoginseng 10 ~ 15 parts, Flos Magnoliae 10 ~ 15 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 15 parts, Faeces Passeris 10 ~ 15 parts, Herba Asari 10 ~ 15 parts, Radix Ampelopsis 10 ~ 15 parts, Radix Angelicae Pubescentis 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, the Radix Angelicae Dahuricae 10 ~ 20 parts, Radix Oenotherae erythrosepalae 10 ~ 20 parts, Margarita 10 ~ 20 parts, Flos Rosae Chinensis 10 ~ 20 parts.

4. according to any one of claims 1 to 3, treat the preparation method of speckle removing Chinese medicine composition of invigorating blood circulation for butterfly spot, chloasma, it is characterized in that, the dosage form of described oral preparations is tablet, and its preparation method comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of components to be merged, be condensed into powder and be mixed into starch film-making.

5. treat the preparation method of tablet of speckle removing Chinese medicine composition of invigorating blood circulation of butterfly spot, chloasma according to claim 4, it is characterized in that, in described step a, get crude drug to add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.32 extractum, stand for standby use, becomes component 1.

6. treat the preparation method of capsule of speckle removing Chinese medicine composition of invigorating blood circulation of butterfly spot, chloasma according to claim 4, it is characterized in that, in described step b, the medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times of water gagings, each 1-2 hour, merge extractive liquid, removes supernatant after leaving standstill, and then 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.32 extractum, stand for standby use, becomes component 2.

7. treat the preparation method of tablet of speckle removing Chinese medicine composition of invigorating blood circulation of butterfly spot, chloasma according to claim 4, it is characterized in that, in described step c, by the merging of component 1 and component 2, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, after obtaining medicated powder drying, mixing starch makes tablet.

8. according to any one of claims 1 to 3, treat the preparation method of speckle removing Chinese medicine composition of invigorating blood circulation for butterfly spot, chloasma, it is characterized in that, the dosage form of described external preparation is that the preparation method of ointment comprises the following steps:

A, get Radix Notoginseng, the Radix Angelicae Dahuricae, Faeces Passeris and Pseudobulbus Bletillae (Rhizoma Bletillae) steam method and distill, obtain crystallization, for subsequent use as component 1;

B, again medicinal residues and the surplus stock medicine after distillation is put into ethanol except Margarita and soak, heat is extracted 2 times, and one-tenth paste is component 2;

C, above-mentioned two kinds of components merged, unguentum made by the Margarita mixing Cera Flava or the vaseline that add pulverizing.

9. treat the preparation method of ointment of speckle removing Chinese medicine composition of invigorating blood circulation of butterfly spot, chloasma according to claim 8, it is characterized in that, in described step a, first Radix Notoginseng, the Radix Angelicae Dahuricae, Faeces Passeris and Pseudobulbus Bletillae (Rhizoma Bletillae) steam method are distilled according to described number, obtain crystal, for subsequent use as component 1.

10. treat butterfly spot according to claim 8, the preparation method of the ointment of the speckle removing Chinese medicine composition of invigorating blood circulation of chloasma, it is characterized in that, in described step b, get the 60-90% soak with ethanol 1-2 hour that the surplus stock of the mixing of the medicinal residues after distillation except Margarita adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, concentrated solution is settled into extractum shape, stand for standby use, become component 2.