CN105343374A - Suppository for treating prostatitis and urination frequency and urgency and preparing method thereof - Google Patents

Suppository for treating prostatitis and urination frequency and urgency and preparing method thereof Download PDF

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CN105343374A
CN105343374A CN201510912995.3A CN201510912995A CN105343374A CN 105343374 A CN105343374 A CN 105343374A CN 201510912995 A CN201510912995 A CN 201510912995A CN 105343374 A CN105343374 A CN 105343374A
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parts
suppository
herba
prostatitis
semen cuscutae
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金宗兰
梁朝朝
张贤生
郝宗耀
高晶晶
汤冬冬
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First Affiliated Hospital of Anhui Medical University
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/884—Alismataceae (Water-plantain family)
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315—Isatis, e.g. Dyer's woad
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/39—Convolvulaceae (Morning-glory family), e.g. bindweed
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses a suppository for treating prostatitis and urination frequency and urgency. The suppository is prepared from, by weight, 3-9 parts of liquorice, 3-10 parts of semen cuscutae, 4-12 parts of herba cynomorii, 3-9 parts of rhizoma alismatis, 5-12 parts of dahurian patrinia herb, 30-45 parts of radix sophorae flavescentis, 9-20 parts of galium aparine, 20-40 parts of gelatin and 4-10 parts of indigo naturalis. The natural botanical drugs are selected as raw materials, the components conform to the regulations of medicine politics and law, the comprehensive effect of the various drugs is utilized for treating prostatitis and urination frequency and urgency, toxicity and harm to the human body are avoided, the side effects are avoided, use is safe and reliable, and the suppository is remarkable in curative effect and free of side effects. The invention aims to provide a preparing method for the suppository.

Description

Suppository for the treatment of prostatitis, urine urgency-frequency and preparation method thereof
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the suppository and preparation method thereof for the treatment of prostatitis, urine urgency-frequency.
Background technology
Prostatitis is the commonly encountered diseases of Urology Surgery, in Urology Surgery male patient the right side of fifty, account for first place.Nineteen ninety-five NIH has formulated a kind of new prostatitis sorting technique, I type: be equivalent to the acute bacterial prostatitis in conventional sorting methods, II type: be equivalent to the chronic bacterial prostatitis in conventional sorting methods, III type: chronic prostatitis/chronic Pelvic Pain Syndrome, IV type: silent prostatitis.Wherein nonbacterial prostatitis is common far beyond bacterial prostatitis.
The cause of disease: only have small number of patients to have acute medical history, shows as chronic, recurrent process more.I type and II type prostatitis main pathogenic are pathogenic infection, and pathogen invades prostate with urine, cause infecting.Pathological anatomy confirms that prostatitis pathological changes is generally confined to peripheral zone, and glandular tube and urine flows that vertical line is reverse is opened on Posterior urethral herein, easily cause urine reflux, and central zone and transitional zone glandular tube trend consistent with urinating flow path direction, not easily infect.III type pathogenesis is not bright, and etiology is very complicated, exists and extensively disputes on.Most scholar thinks that its Etiological may be pathogenic infection, urinary dysfunction, psychologic factors, neuroendocrine factor, immunoreaction abnormity, oxidative stress theory, lower urinary tract epithelium dysfunction etc.IV type lacks relevant pathogenetic research, may be identical with the part cause and onset of disease mechanism of III type.Nearest research also finds that the urate of urine not only has stimulation to prostate, also precipitable one-tenth calculus, and blocking glandular tube, as the protection place of antibacterial.These discoveries can illustrate the coexpress that prostatitis syndrome is various diseases in fact, and complicated clinical manifestation is changeable, can produce various complication, also can spontaneous remission.
Clinical manifestation: I type regular incidence is unexpected, shows as shiver with cold, heating, the General Symptomies such as fatigue and weak, with perineal position and suprapubic pain, even acute urinary retention.II type is similar with III type clinical symptoms, has pain and paruria etc. more.No matter which kind chronic prostatitis all can show as similar clinical symptom, be referred to as prostatitis disease group, comprise basin sacrum pain, paruria and sexual dysfunction.Basin sacrum pain present is extremely complicated, pain is generally positioned on pubis, lumbosacral region and perineal position, and radiating pain can show as urethra, spermatic cord, testis, groin, abdomen medial part pain, and ventrad radiation exactly likes acute abdomen, exactly like renal colic along urinary tract radiation, often cause mistaken diagnosis.Paruria shows as frequent micturition, urgent micturition, dysurea, it is smooth to urinate, after splitting of urinary stream, urine drop drip, nocturia increased frequency, after urine or stool time urethra flow out milky secretions etc.Concurrency dysfunction once in a while, comprises hyposexuality, premature ejaculation, painful ejaculation, erection weakens and sexual impotence.IV type is without clinical symptoms.
Frequent micturition is a kind of symptom, and non-diseases.Because many reasons can cause total urination time to increase, but without pain, also known as frequent micturition.The reason of frequent micturition is more, comprises psychoneural factor, and body is empty after being ill, parasitic disease etc.Urinary tract infection, pudendum or penis local inflammation etc. except frequent micturition infant is needed.Urgent micturition refers to that patient one has urine meaning and too impatient needs to urinate, and is difficult to control.
At present, treatment prostatitis, the medicine of urine urgency-frequency also has a lot, for the problems referred to above, the Chinese patent literature of Authorization Notice No. CN102100845B (application number 201110026064.5) discloses a kind for the treatment of and to suffer from a deficiency of the kidney deficiency of the kidney and urine urgency-frequency and prostatitic medicine, it is characterized in that: it is formed by the prepared from traditional Chinese medicines of following weight portion: Rhizoma Curculiginis 110 ~ 130 parts, Radix Polygoni Multiflori 110 ~ 130 parts, Radix Ginseng 80 ~ 100 parts, Hippocampus 55 ~ 65 parts, Fructus Corni 55 ~ 65 parts, Fructus Psoraleae 55 ~ 65 parts, Rhizoma Polygonati 110 ~ 130 parts, 55 ~ 65 parts, Cornu Cervi Pantotrichum, Herba Cynomorii 80 ~ 100 parts, Radix Salviae Miltiorrhizae 80 ~ 100 parts, Rhizoma Dioscoreae Septemlobae 55 ~ 65 parts, Herba Epimedii 55 ~ 65 parts, the Radix Astragali 110 ~ 130 parts, Radix Rehmanniae 55 ~ 65 parts, Radix Rehmanniae Preparata 55 ~ 65 parts, Radix Asparagi 55 ~ 65 parts, Radix Ophiopogonis 55 ~ 65 parts, Fructus Schisandrae Chinensis 55 ~
65 parts, Fructus Lycii 55 ~ 65 parts, Rhizoma Dioscoreae 55 ~ 65 parts, Poria 55 ~ 65 parts, Testis et penis callorhini 110 ~ 130 parts, Fructus Crataegi 80 ~ 100 parts, Fructus Rubi 55 ~ 65 parts, Radix Achyranthis Bidentatae 55 ~ 65 parts, Semen Platycladi 55 ~ 65 parts, the Cortex Eucommiae 55 ~ 65 parts, Radix Angelicae Sinensis 55 ~ 65 parts, Radix Morindae Officinalis 55 ~ 65 parts, Semen Cuscutae 55 ~ 65 parts, Herba Cistanches 55 ~ 65 parts, Radix Polygalae 55 ~ 65 parts, Cortex Phellodendri 55 ~ 65 parts, the Rhizoma Anemarrhenae 55 ~ 65 parts, Cortex Cinnamomi 25 ~ 35 parts, Placenta Hominis 40 ~ 50 parts, Radix Aconiti Lateralis Preparata 25 ~ 35 parts, linum 55 ~ 65 parts.
In a word, current Chinese medicine before a remission row adenitis, urine urgency-frequency aspect achieves certain effect, but also there are some problems, desirable not enough to the therapeutic effect of prostatitis, urine urgency-frequency clinically, need further raising.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of suppository preparing simple, easy to use, portable treatment prostatitis, urine urgency-frequency.It selects natural plant to be raw material, each component meets pharmaceutical control law regulation, utilize comprehensive function treatment prostatitis, the urine urgency-frequency of each taste medicine, harmless to human non-toxic, have no side effect, safe and reliable, this suppository is evident in efficacy and have no side effect, and another object of the present invention is just to provide the preparation method of above-mentioned suppository.Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The suppository for the treatment of prostatitis, urine urgency-frequency, take off the primary raw material stating weight proportion to be prepared from: Radix Glycyrrhizae 3-9 part, Semen Cuscutae 3-10 part, Herba Cynomorii 4-12 part (preferred 7-9 part), Rhizoma Alismatis 3-9 part, Herba Patriniae 5-12 part, Radix Sophorae Flavescentis 30-45 part, Herba Galii Teneri 9-20 part, gelatin 20-40 part, Indigo Naturalis 4-10 part.
The suppository for the treatment of prostatitis, urine urgency-frequency, preferred scheme is, take off the primary raw material stating weight proportion to be prepared from: Radix Glycyrrhizae 5-7 part, Semen Cuscutae 5-8 part, Herba Cynomorii 6-10 part, Rhizoma Alismatis 5-7 part, Herba Patriniae 7-10 part, Radix Sophorae Flavescentis 35-40 part, Herba Galii Teneri 13-16 part, gelatin 25-35 part, Indigo Naturalis 6-8 part.
The suppository for the treatment of prostatitis, urine urgency-frequency, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: 6 parts, Radix Glycyrrhizae, Semen Cuscutae 7 parts, Herba Cynomorii 8 parts, Rhizoma Alismatis 6 parts, Herba Patriniae 9 parts, Radix Sophorae Flavescentis 40 parts, Herba Galii Teneri 15 parts, 30 parts, gelatin, Indigo Naturalis 7 parts.
The preparation method of described suppository is:
(1) Radix Glycyrrhizae is cleaned, section, add cooked Mel and Radix Glycyrrhizae weight 1-2 boiled water doubly, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add Semen Cuscutae weight 4-6 hydromel doubly, moderate heat decocts 20-40 minute, keeps 80-90 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 5-15 minute with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 20-40 circle clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
The preparation method of above-mentioned suppository, preferred scheme, step (1) adds cooked Mel and Radix Glycyrrhizae weight 1.3-1.8 boiled water (preferably adding the boiled water of cooked Mel and Radix Glycyrrhizae weight 1.5 times) doubly.
The preparation method of above-mentioned suppository powder, preferred scheme, step (2) adds Semen Cuscutae weight 4.5-5.5 hydromel (preferably adding the hydromel of Semen Cuscutae weight 5 times) doubly.
The preparation method of above-mentioned suppository powder, preferred scheme, step (2) keeps 83-88 DEG C of set aside for use (preferably keeping 85 DEG C of set aside for use).
The preparation method of above-mentioned suppository, preferred scheme: step (2) moderate heat decocts 25-35 minute (preferred moderate heat decocts 30 minutes).
The preparation method of above-mentioned suppository, preferred scheme: 8-13 minute (preferably frying 10 minutes with Sal) fried by step (3) Sal.
The preparation method of above-mentioned suppository, preferred scheme: step (4) stirs 25-35 circle (preferably stirring 30 circles clockwise) clockwise.
Using method: adopt the present invention to treat the suppository of prostatitis, urine urgency-frequency, peel off the aluminium foil or polyethylene film wrapped up in outside suppository, dip in a little vegetable oil on suppository top, suppository is slowly pushed 2 ~ 3 centimetres, anus; Every day is each one piece of suppository sooner or later, twice on the one.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Glycyrrhizae: for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc., for asthma and cough, licoflavone, Radix Glycyrrhizae extractum and enoxolone all have obvious antitussive effect; Phlegm-dispelling functions is also comparatively remarkable, and its action intensity is glycyrrhizic acid > licoflavone > Radix Glycyrrhizae extractum.Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.
Semen Cuscutae: be the herb of Convolvulaceae Hellweed Semen Cuscutae.Composition: Semen Cuscutae is containing alkaloid, anthraquinone, coumarin, flavone, glycoside, sterol, tannic acid, saccharide etc.Flavonoid has: Quercetin, astragalin, hyperin; Sterols has: cholesterol, campesterol, cupreol, stigmasterol, β-Amyrin.Also trace element is contained as strontium, molybdenum, calcium, magnesium, ferrum, manganese, zinc, copper etc. and several amino acids (free amino acid in seed and the total amino acids after being hydrolyzed are 5.3%, and wherein the content of essential amino acids accounts for 42.8%).The property of medicine: micro-pungent, sweet, flat, nontoxic.Function cures mainly: the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.
Herba Cynomorii: Ulan height waist, ball top, sheep lock do not draw, Latin literary fame: CynomoriumsongaricumRupr. Cynomoriaceae, Herba Cynomorii belong to the parasitic draft of perennial meat, and without chlorophyll, Herb rufous, high 15-100 centimetre, major part is embedded in sand.Can the kidney invigorating, benefit essence, moisturize, cure mainly impotence and seminal emission, soreness of the waist and knees, dryness of the intestine constipation, to paralysis with improvement function is weak has certain effect.
Rhizoma Alismatis: cure mainly oedema due to nephritis, the disease such as pyelonephritis, enteritis are had loose bowels, dysuria.Diuretic, eliminating dampness by diuresis, expels the heat-evil.Control dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
Herba Patriniae: Herba Patriniae is cold in nature to be slightly cold, acrid in the mouth is bitter: " this grass has old gas, therefore gains the name with Herba Patriniae ".Pungent loose being apt to of Herba Patriniae is fallen, and its effect can reach, in, lower three is burnt.With Herba Taraxaci, Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Cynanchi Paniculati compatibility, regulating qi-flowing for harmonizing stomach, controls bile reflux gastritis.With Caulis Sargentodoxae, Radix Paeoniae Rubra, Rhizoma Curcumae compatibility, disappear hot dissipating blood stasis, controls chronic pelvic inflammatory disease.With Semen Coicis, Radix Rhapontici, Rhizoma Polygoni Cuspidati compatibility, heat-clearing and toxic substances removing, controls damp and hot arthromyodynia.Study carefully its pharmacology, Herba Patriniae has antiviral, antitumor, function of gallbladder promoting, diuresis, the effects such as stimulated hepatic cell regeneration.
Radix Sophorae Flavescentis: Radix Sophorae Flavescentis, Chinese medicine name.For the dry root of leguminous plant Radix Sophorae Flavescentis, spring, Qiu Erji excavate, removing root head and little supporting root, cleaning, drying, or take advantage of fresh slices, dry.It is bitter, cold.There is heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Herba Galii Teneri: have another name called saw grass, draw rattan, fly upward rattan, the herb of taste Rubiaceae clivers Herba Galii Teneri or thick Ye Lala rattan.The property of medicine: herb is very thin, easily broken, the grayish green or green and brown color in surface, feeble QI, acrid in the mouth, bitter in the mouth, cold nature.Composition: Herba Galii Teneri aerial parts is containing alkaloid, and fruit contains Fructus Hordei Germinatus amine, jaligonic acid etc.; Thick Ye Lala rattan aerial parts contains asperuloside, vitamin C.Find according to modern pharmacological research, this medical instrument has antibacterial, anticancer, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain effect, for swollen ulcer drug, and appendicitis, cold, fever, hematuria etc.
Gelatin: gelatin (Gelatin), does not have fixing structure and relative molecular weight, is degraded and become thin slice or the powder of white or faint yellow, translucent, micro-band gloss by the collagenous portion in the connective tissues such as animal skin, bone, sarolemma, flesh evil spirit; Be a kind of colorless and odorless, non-volatility, transparent hard amorphous material, dissolve in hot water, be insoluble to cold water, but can slowly imbibition soften, and gelatin Absorbable rod is equivalent to weight 5-10 water doubly.
Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.The property of medicine: this product is navy blue powder, body is light, and easily fly upward, micro-have careless stink smell, salty in the mouth, cold in nature.Composition: its main component has indirubin, indigo.Find according to modern pharmacological research, this medical instrument has effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.
Suppository of the present invention is based on the principle of traditional Chinese medical herbal treatment, make on the basis that have studied lot of documents, pharmacology work and clinical trial, this suppository according to the body and mind feature of Chinese medicine principle and diarrhoea or flatulence patient, has good therapeutic effect to prostatitis, urine urgency-frequency completely.
technical advantage of the present invention is embodied in:
1, raw material multiselect natural plant of the present invention, harmless to human non-toxic, safe and reliable.
2, raw material of Chinese medicine of the present invention is through dialectical compatibility, coordinates with spreading mutually at work, thus effectively plays its healing prostatitis, colpitic effect, has significant curative effect to treatment prostatitis, urine urgency-frequency.
3, medical material medicine source is easy to get, and medical material is with low cost, can not bring large financial burden to patient.
Detailed description of the invention
embodiment 1the suppository for the treatment of prostatitis, urine urgency-frequency, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): 3 parts, Radix Glycyrrhizae, Semen Cuscutae 3 parts, Herba Cynomorii 4 parts, Rhizoma Alismatis 3-9 part, Herba Patriniae 5 parts, Radix Sophorae Flavescentis 30 parts, Herba Galii Teneri 9 parts, 20 parts, gelatin, Indigo Naturalis 4 parts.
The preparation method of the suppository for the treatment of prostatitis, urine urgency-frequency is:
(1) Radix Glycyrrhizae is cleaned, section, add the boiled water of cooked Mel and Radix Glycyrrhizae weight 1 times, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add the hydromel of Semen Cuscutae weight 4 times, moderate heat decocts 20 minutes, keeps 80 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 5 minutes with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 20 circles clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
model case onezhao XX, female, 50 years old, Heze City He Lou people from town.More than private prosecution frequent micturition, urgent micturition companion trouble urinating half a year, and it is clammy to feel scrotum, perineal position pain, nocturia 5-6 time, and once in outer court's diagnosis and treatment, mouth made antibiotic therapy, and symptom is without improvement, and patient examination anus examines prostate I ° size, has mild tenderness; Prostatic fluid routine prompting: lecithin is a small amount of, leukocyte +++ +/Hp; Urinalysis shows no obvious abnormalities, and is diagnosed as " chronic prostatitis "
Use the suppository of embodiment 1 gained treatment prostatitis, urine urgency-frequency after 10 days, nocturia 0-1 time after three weeks, dampness of scrotum disappears substantially, look into prostatic fluid lecithin ++/Hp, leukocyte +/Hp, see that malaise symptoms alleviates to some extent, continue again to use the suppository 7 days of embodiment 1 gained treatment prostatitis, urine urgency-frequency, patient's self-induction heals entirely.
embodiment 2the suppository for the treatment of prostatitis, urine urgency-frequency, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): 5 parts, Radix Glycyrrhizae, Semen Cuscutae 5 parts, Herba Cynomorii 7 parts, Rhizoma Alismatis 5 parts, Herba Patriniae 7 parts, Radix Sophorae Flavescentis 35 parts, Herba Galii Teneri 13 parts, 40 parts, gelatin, Indigo Naturalis 10 parts.
The preparation method of the suppository powder for the treatment of prostatitis, urine urgency-frequency is:
(1) Radix Glycyrrhizae is cleaned, section, add the boiled water of cooked Mel and Radix Glycyrrhizae weight 2 times, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add the hydromel of Semen Cuscutae weight 6 times, moderate heat decocts 40 minutes, keeps 90 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 15 minutes with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 40 circles clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
embodiment 3the suppository for the treatment of prostatitis, urine urgency-frequency, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): 6 parts, Radix Glycyrrhizae, Semen Cuscutae 7 parts, Herba Cynomorii 8 parts, Rhizoma Alismatis 6 parts, Herba Patriniae 9 parts, Radix Sophorae Flavescentis 40 parts, Herba Galii Teneri 15 parts, 25 parts, gelatin, Indigo Naturalis 6 parts.
The preparation method of the suppository for the treatment of prostatitis, urine urgency-frequency is:
(1) Radix Glycyrrhizae is cleaned, section, add the boiled water of cooked Mel and Radix Glycyrrhizae weight 1.3 times, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add the hydromel of Semen Cuscutae weight 4.5 times, moderate heat decocts 25 minutes, keeps 83 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 8 minutes with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 25 circles clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
embodiment 4:the suppository for the treatment of prostatitis, urine urgency-frequency, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): 6 parts, Radix Glycyrrhizae, Semen Cuscutae 7 parts, Herba Cynomorii 8 parts, Rhizoma Alismatis 6 parts, Herba Patriniae 9 parts, Radix Sophorae Flavescentis 40 parts, Herba Galii Teneri 15 parts, 35 parts, gelatin, Indigo Naturalis 8 parts.
The preparation method of the suppository for the treatment of prostatitis, urine urgency-frequency is:
(1) Radix Glycyrrhizae is cleaned, section, add the boiled water of cooked Mel and Radix Glycyrrhizae weight 1.8 times, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add the hydromel of Semen Cuscutae weight 5.5 times, moderate heat decocts 35 minutes, keeps 88 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 13 minutes with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 35 circles clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
model case two:lee XX, man, 48 years old, Jinan, Shandong Province people, peasant, be engaged in building constructor, make a definite diagnosis through County Hospital, suffer from cardiovascular and cerebrovascular disease, deficiency of the kidney of suffering from a deficiency of the kidney, the various diseases such as urine urgency-frequency, and integrative therapy in many ways, heavy time light during the state of an illness, effect is all not obvious, last and reach 5 years, having a dizzy spell appears in nearest patient, paroxysmal numb limbs and tense tendons, lumbocrural pain, weak, urine urgency-frequency, daily life activity difficulty, needs people to look after, in particularly evening, urine reaches six times, blood pressure 180/110mmhg, through being diagnosed as prostatitis.
Use the suppository of embodiment 4 gained treatment prostatitis, urine urgency-frequency after 7 days, various symptom is all alleviated, blood pressure is normal, and symptom all disappears, and clinical pulse condition is normal, and can simple work be engaged in, see that malaise symptoms alleviates to some extent, continue again to use the suppository 20 days of embodiment 4 gained treatment prostatitis, urine urgency-frequency, cardiovascular and cerebrovascular disease, deficiency of the kidney of suffering from a deficiency of the kidney and frequent micturition urinate the recovery from illness of all diseases, after continue medicine two weeks is consolidated according to advising again, pay a return visit so far without recur.
embodiment 5:the suppository for the treatment of prostatitis, urine urgency-frequency, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): 6 parts, Radix Glycyrrhizae, Semen Cuscutae 7 parts, Herba Cynomorii 8 parts, Rhizoma Alismatis 6 parts, Herba Patriniae 9 parts, Radix Sophorae Flavescentis 40 parts, Herba Galii Teneri 15 parts, 30 parts, gelatin, Indigo Naturalis 7 parts.
The preparation method of the suppository for the treatment of prostatitis, urine urgency-frequency is:
(1) Radix Glycyrrhizae is cleaned, section, add the boiled water of cooked Mel and Radix Glycyrrhizae weight 1.5 times, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add the hydromel of Semen Cuscutae weight 5 times, moderate heat decocts 30 minutes, keeps 85 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 10 minutes with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 30 circles clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
test example:the clinical practice of the suppository of embodiment 5 gained treatment prostatitis, urine urgency-frequency: in January ,-2015 in May, 2011,200 routine patients are screened in hospital, wherein woman 100 example, man 100 example, before test, Continuous Observation is carried out to this crowd, record symptom and change, be divided into two groups, experimental group and matched group at random, experimental group uses the suppository of embodiment 5 gained treatment prostatitis, urine urgency-frequency, and matched group uses the medicine of other treatment prostatitis, urine urgency-frequency.
Using method is: adopt the present invention to treat the suppository of prostatitis, urine urgency-frequency, peel off the aluminium foil or polyethylene film wrapped up in outside suppository, dip in a little vegetable oil on suppository top, suppository is slowly pushed 2 ~ 3 centimetres, anus; Every day is each one piece of suppository sooner or later, twice on the one.
Curative effect situation criterion: cure: after medication, malaise symptoms disappears completely; Effective: after medication, malaise symptoms alleviates or partial disappearance; Invalid: after medication, the recurrence of malaise symptoms unchanged or later stage.Result is as follows:
Table 1
Therapeutic effect: use the present invention treat prostatitis, urine urgency-frequency the cure rate of suppository up to 81%, total effective rate 99%, inefficiency is only 1%; And using the cure rate of the medicine of other treatment prostatitis, urine urgency-frequency only to reach 32%, inefficiency is but up to 9%.Use the relapse rate of the medicine of other treatment prostatitis, urine urgency-frequency relatively high, much can not thoroughly cure.As can be seen from Table 1: use the present invention to treat prostatitis, medicine that the successful of suppository of urine urgency-frequency is better than using other treatment prostatitis, urine urgency-frequency.
Table 2
As can be seen from Table 2: after using the present invention to treat the suppository of prostatitis, urine urgency-frequency, most of patients symptom is all well improved substantially, various symptom is obviously alleviated, to bacterial prostatitis, the effective percentage of experimental group, anxious, slow bacterial prostatitis patient cure rate apparently higher than matched group, to nonbacterial prostatitis, the effective percentage of this medicine, all apparently higher than matched group, has significant curative effect with this drug treatment nonbacterial prostatitis.

Claims (10)

1. treat the suppository of prostatitis, urine urgency-frequency, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Glycyrrhizae 3-9 part, Semen Cuscutae 3-10 part, Herba Cynomorii 4-12 part (preferred 7-9 part), Rhizoma Alismatis 3-9 part, Herba Patriniae 5-12 part, Radix Sophorae Flavescentis 30-45 part, Herba Galii Teneri 9-20 part, gelatin 20-40 part, Indigo Naturalis 4-10 part.
2. the suppository for the treatment of prostatitis according to claim 1, urine urgency-frequency, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Radix Glycyrrhizae 5-7 part, Semen Cuscutae 5-8 part, Herba Cynomorii 6-10 part, Rhizoma Alismatis 5-7 part, Herba Patriniae 7-10 part, Radix Sophorae Flavescentis 35-40 part, Herba Galii Teneri 13-16 part, gelatin 25-35 part, Indigo Naturalis 6-8 part.
3. the suppository for the treatment of prostatitis according to claim 1, urine urgency-frequency, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: 6 parts, Radix Glycyrrhizae, Semen Cuscutae 7 parts, Herba Cynomorii 8 parts, Rhizoma Alismatis 6 parts, Herba Patriniae 9 parts, Radix Sophorae Flavescentis 40 parts, Herba Galii Teneri 15 parts, 30 parts, gelatin, Indigo Naturalis 7 parts.
4. according to any one of claim 1-3, treat the preparation method of suppository of prostatitis, urine urgency-frequency, it is characterized in that: step is as follows:
(1) Radix Glycyrrhizae is cleaned, section, add cooked Mel and Radix Glycyrrhizae weight 1-2 boiled water doubly, mix thoroughly, slightly vexed, put in pot and fry to becoming buff, tack-free for spending with slow fire, taking-up cools, and grinds stand-by;
(2) Semen Cuscutae is cut into the block of small rice grain size, is placed in marmite, add Semen Cuscutae weight 4-6 hydromel doubly, moderate heat decocts 20-40 minute, keeps 80-90 DEG C of set aside for use;
(3) Herba Cynomorii, Rhizoma Alismatis, Herba Patriniae, Radix Sophorae Flavescentis and Herba Galii Teneri are cut into block, are placed in preheated container, fry 5-15 minute with Sal, sieve removes Sal, dries in the air stand-by to the crisp smalls that grinds to form;
(4) step (1) and step (3) gained medicamental pulverata are placed in step (2) gained medicinal liquid, decoct while stir, temperature cool to room temperature, add Indigo Naturalis, stir 20-40 circle clockwise, gelatin is placed in evaporating dish, heat fused in water-bath, adds the thick paste mixed, stir, whole material is poured in supp anal mould, slightly overflows mould, finally scrape off spilling part, treat abundant cooled and solidified, carefully open model, take out suppository, pack with aluminium foil or polyethylene film and get final product.
5. the preparation method of suppository according to claim 4, is characterized in that: step (1) adds cooked Mel and Radix Glycyrrhizae weight 1.3-1.8 boiled water (preferably adding the boiled water of cooked Mel and Radix Glycyrrhizae weight 1.5 times) doubly.
6. the preparation method of suppository powder according to claim 4, is characterized in that: step (2) adds Semen Cuscutae weight 4.5-5.5 hydromel (preferably adding the hydromel of Semen Cuscutae weight 5 times) doubly.
7. the preparation method of suppository powder according to claim 4, is characterized in that: step (2) keeps 83-88 DEG C of set aside for use (preferably keeping 85 DEG C of set aside for use).
8. the preparation method of suppository according to claim 4, is characterized in that: step (2) moderate heat decocts 25-35 minute (preferred moderate heat decocts 30 minutes).
9. the preparation method of suppository according to claim 4, is characterized in that: 8-13 minute (preferably frying 10 minutes with Sal) fried by step (3) Sal.
10. the preparation method of suppository according to claim 4, is characterized in that: step (4) stirs 25-35 circle (preferably stirring 30 circles clockwise) clockwise.
CN201510912995.3A 2015-12-11 2015-12-11 Suppository for treating prostatitis and urination frequency and urgency and preparing method thereof Pending CN105343374A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100845A (en) * 2011-01-25 2011-06-22 李文杰 Medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis
CN103479966A (en) * 2013-09-10 2014-01-01 中国人民解放军第三七一医院 Traditional Chinese preparation for treating prostatitis
CN104116920A (en) * 2014-07-19 2014-10-29 王健芳 Viable bacteria mixture for treating diarrhea with flatulence and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102100845A (en) * 2011-01-25 2011-06-22 李文杰 Medicament for treating deficiency of kidney, frequent micturition, urgent urination and prostatitis
CN103479966A (en) * 2013-09-10 2014-01-01 中国人民解放军第三七一医院 Traditional Chinese preparation for treating prostatitis
CN104116920A (en) * 2014-07-19 2014-10-29 王健芳 Viable bacteria mixture for treating diarrhea with flatulence and preparation method thereof

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