CN105343122A - Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation - Google Patents
Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation Download PDFInfo
- Publication number
- CN105343122A CN105343122A CN201510696595.3A CN201510696595A CN105343122A CN 105343122 A CN105343122 A CN 105343122A CN 201510696595 A CN201510696595 A CN 201510696595A CN 105343122 A CN105343122 A CN 105343122A
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- CN
- China
- Prior art keywords
- polyhexamethylene guanidine
- powder
- poultry
- fish
- guanidine propionate
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Abstract
The invention discloses a propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation and relates to the technical field of pharmaceuticals. The livestock, poultry and fish pharmaceutical preparation is livestock, poultry and fish pharmaceutical powder or capsules and is composed of, by weight, 0.01-30% of propanoic acid polyhexamethylene guanidine, 0.01-10% of Arbidol hydrochloride, 20-85% of anhydrous glucose, 5-20% of corn starch and 5-20% of Fumei powder; a pharmaceutical feed additive is pharmaceutical feed additive powder or water and is composed of, by weight, 0.01-30% propanoic acid polyhexamethylene guanidine, 0.01-20% of synergist, 0.01-0.4% of Acesulfame, 5-20% of corn starch, 5-20% of Fumei powder, 10-90% of anhydrous glucose and 50-99% of purified water. The livestock, poultry and fish pharmaceutical preparation is not resistant to various bacteria, fungi and viruses and is quick to act and free of pharmaceutical resistance, side effect and environment pollution.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, be specifically related to the pharmaceutical preparation of polyhexamethylene guanidine propionate poultry fish.
Background technology
At present, poultry fish medicine and the medicated feed additive for the treatment of poultry fish digestive system infection mostly are antibiotic, example hydrochloric acid ciprofloxacin, Norfloxacin Lactate, enrofloxacin, amoxicillin etc.Poultry fish life-time service antibiotic, not only increases the Drug resistance of pathogenic bacteria, and causes antibiotic to exceed standard.Antibiotic residual not only direct to the effect of poultry fish generation acute toxicity and chronic toxicity, also indirectly potential hazard is caused to health, simultaneously to environment by the effect of environment and food chain.
Polyhexamethylene guanidine propionate, environment-friendly type macromolecule polymer, does not also report digestive system infection diseases such as being used for the treatment of poultry colibacillosis, bacterial diarrhea, avian typhoid, paratyphoid fever, fowl cholera, Pullorum Disease, yellow scour of piglet, Hakuri, fish bacterial disease at present at home.
Summary of the invention
The object of the invention is to the defect for prior art and deficiency, there is provided a kind of reasonable in design, make the pharmaceutical preparation of simple polyhexamethylene guanidine propionate poultry fish, the splitting function of effective anti-bacteria, fungus, virus, antibacterial, fungus, virus is made to lose reproductive performance and be choked to death rapidly, and it does not develop immunity to drugs to each bacterioid, fungus, virus, effect is fast, without Drug resistance, have no side effect, free from environmental pollution.
For achieving the above object, the technical solution used in the present invention is: it is poultry fish medicine or medicated feed additive; Described poultry fish medicine is poultry fish drug powder or poultry fish medicament capsule,, its constituent percentage by weight is as follows: polyhexamethylene guanidine propionate 0.01%-30%, arbidol HCl 0.01%-10%, anhydrous glucose 20%-85%, corn starch 5%-20%, auxiliary U.S. powder 5%-20%; Described medicated feed additive is medicated feed additive powder or medicated feed additive water preparation, and its constituent percentage by weight is as follows: polyhexamethylene guanidine propionate 0.01%-30%, synergist 0.01%-20%, acesulfame potassium 0.01%-0.4%, corn starch 5%-20%, auxiliary U.S. powder 5%-20%, anhydrous glucose 10%-90%, pure water 50%-99%.
The processing technique of described poultry fish medicine is as follows:
1, polyhexamethylene guanidine propionate and auxiliary U.S. powder are stirred 20-40 minute according to aforementioned proportion mixing, obtain mixture A;
2, arbidol HCl and corn starch are stirred 20-40 minute according to aforementioned proportion mixing, obtain mixture B;
3, according to aforementioned proportion, anhydrous glucose and mixture A, mixture B are mixed and stirs 20-40 minute, obtain polyhexamethylene guanidine propionate poultry fish drug powder.
(4) polyhexamethylene guanidine propionate poultry fish drug powder is loaded in capsule according to a certain amount of, namely obtains polyhexamethylene guanidine propionate poultry fish medicament capsule.
The processing technique of described medicated feed additive is as follows:
1, polyhexamethylene guanidine propionate, synergist and auxiliary U.S. powder are stirred 20-40 minute according to aforementioned proportion mixing, obtain mixture A;
2, corn starch, anhydrous glucose are stirred 20-40 minute according to aforementioned proportion mixing, obtain mixture B;
3, according to aforementioned proportion, 20-40 minute is stirred in mixture A, mixture B mixing, obtains polyhexamethylene guanidine propionate medicated feed additive powder;
4, according to aforementioned proportion, 20-40 minute is stirred in polyhexamethylene guanidine propionate, synergist, acesulfame potassium, pure water mixing, obtains polyhexamethylene guanidine propionate medicated feed additive water preparation.
Operation principle of the present invention: the effective anti-bacteria of polyhexamethylene guanidine propionate medicine energy, fungus, the splitting function of virus, make antibacterial, fungus, virus loses reproductive performance, add the thin film that polymer is formed, plug antibacterial, fungus, the respiration channel of virus, make antibacterial, fungus, virus is choked to death rapidly, its special sterilization mechanism, to each bacterioid, fungus, virus does not develop immunity to drugs, and bactericidal effect is not by antibacterial, fungus, the impact of virus variation, this medicine enters in body not by Cell uptake, through stomach, directly excrete after intestinal, have no side effect.
Beneficial effect of the present invention is: polyhexamethylene guanidine propionate poultry fish of the present invention pharmaceutical preparation, the splitting function of effective anti-bacteria, fungus, virus, antibacterial, fungus, virus is made to lose reproductive performance and be choked to death rapidly, and it does not develop immunity to drugs to each bacterioid, fungus, virus, effect is fast, without Drug resistance, have no side effect, free from environmental pollution.
Detailed description of the invention
For achieving the above object, the technical scheme that this detailed description of the invention adopts is: it is poultry fish medicine or medicated feed additive; Described poultry fish medicine is poultry fish drug powder or poultry fish medicament capsule, its constituent percentage by weight is as follows: polyhexamethylene guanidine propionate 5%, arbidol HCl 5%, anhydrous glucose 70%, corn starch 8%, auxiliary U.S. powder 12%; Described medicated feed additive is medicated feed additive powder or medicated feed additive water preparation, and its constituent percentage by weight is as follows: polyhexamethylene guanidine propionate 5%, synergist 1%, acesulfame potassium 0.3%, corn starch 9%, auxiliary U.S. powder 10%, anhydrous glucose 75%, pure water 93.7%.
The processing technique of described poultry fish medicine is as follows:
1, polyhexamethylene guanidine propionate and auxiliary U.S. powder are mixed stirring 30 minutes according to aforementioned proportion, obtain mixture A;
2, arbidol HCl and corn starch are mixed stirring 30 minutes according to aforementioned proportion, obtain mixture B;
3, according to aforementioned proportion, anhydrous glucose and mixture A, mixture B are mixed stirring 30 minutes, obtain polyhexamethylene guanidine propionate poultry fish drug powder.
(4) polyhexamethylene guanidine propionate poultry fish drug powder is loaded in capsule according to a certain amount of, namely obtains polyhexamethylene guanidine propionate poultry fish medicament capsule.
The processing technique of described medicated feed additive is as follows:
1, polyhexamethylene guanidine propionate, synergist and auxiliary U.S. powder are mixed stirring 30 minutes according to aforementioned proportion, obtain mixture A;
2, corn starch, anhydrous glucose are mixed stirring 30 minutes according to aforementioned proportion, obtain mixture B;
3, according to aforementioned proportion, mixture A, mixture B are mixed stirring 30 minutes, obtains polyhexamethylene guanidine propionate medicated feed additive powder;
4, according to aforementioned proportion, polyhexamethylene guanidine propionate, synergist, acesulfame potassium, pure water are mixed stirring 30 minutes, obtains polyhexamethylene guanidine propionate medicated feed additive water preparation.
The operation principle of this detailed description of the invention:
1, direct effect is rapid-action: directly interacts with pathogenic bacteria after entering the intestines and stomach, being attracted each other by positive and negative charge is wound around and wraps up pathogenic bacteria, and cut-out pathogenic bacteria nutrient absorption passage also suppresses it to divide, and pathogenic bacteria is choked to death.Other similar drugs are participate in cellular metabolism and upset or check metabolic pathway and reach sterilization object substantially;
2, do not absorb and do not remain: effective ingredient is macromolecule polyalcohol, can not absorb by digested pipe mucomembranous epithelial cell, directly excreted with stool form by large intestine after entering the intestines and stomach.Other similar drugs then can enter blood and lymph fluid through digestive tube mucomembranous epithelial cell, extensively distribute and residue in each tissue, body fluid, as liver, kidney, lung, prostate, testis, uterus and bile, sputum, vesicle liquid, blood, urine etc.;
3, without Drug resistance: unique pathogenic bacteria principle (parcel pathogenic bacteria suppresses division to make it be choked to death) of killing makes it without Drug resistance, and long-term taking effect does not subtract;
4, have no side effect: enter in poultry body not absorb and do not remain, directly excrete, poultry are had no side effect.Also can not indirectly be worked the mischief to human body by food chain.
5, free from environmental pollution: to be finally degraded to carbon dioxide, water at occurring in nature; Nitrogen element is generated nitrate by nitrobacteria effect in water or in layer of sand usually, becomes the nutrient substance be absorbed and used by plants.Therefore, degradation product environmentally safe.
This detailed description of the invention beneficial effect is polyhexamethylene guanidine propionate poultry fish pharmaceutical preparation described in this detailed description of the invention, the splitting function of effective anti-bacteria, fungus, virus, antibacterial, fungus, virus is made to lose reproductive performance and be choked to death rapidly, and it does not develop immunity to drugs to each bacterioid, fungus, virus, effect is fast, without Drug resistance, have no side effect, free from environmental pollution.
The above, only in order to technical scheme of the present invention to be described and unrestricted, other amendment that those of ordinary skill in the art make technical scheme of the present invention or equivalently to replace, only otherwise depart from the spirit and scope of technical solution of the present invention, all should be encompassed in the middle of right of the present invention.
Claims (2)
1. polyhexamethylene guanidine propionate poultry fish pharmaceutical preparation, is characterized in that: it is poultry fish medicine or medicated feed additive; Described poultry fish medicine is poultry fish drug powder or poultry fish medicament capsule, and its constituent percentage by weight is as follows: polyhexamethylene guanidine propionate 0.01%-30%, arbidol HCl 0.01%-10%, anhydrous glucose 20%-85%, corn starch 5%-20%, auxiliary U.S. powder 5%-20%; Described medicated feed additive is medicated feed additive powder or medicated feed additive water preparation, and its constituent percentage by weight is as follows: polyhexamethylene guanidine propionate 0.01%-30%, synergist 0.01%-20%, acesulfame potassium 0.01%-0.4%, corn starch 5%-20%, auxiliary U.S. powder 5%-20%, anhydrous glucose 10%-90%, pure water 50%-99%.
2. polyhexamethylene guanidine propionate poultry fish pharmaceutical preparation, is characterized in that:
The processing technique of described poultry fish medicine is as follows:
(1), by polyhexamethylene guanidine propionate and auxiliary U.S. powder stir 20-40 minute according to aforementioned proportion mixing, obtain mixture A;
(2), by arbidol HCl and corn starch stir 20-40 minute according to aforementioned proportion mixing, obtain mixture B;
(3), according to aforementioned proportion, anhydrous glucose and mixture A, mixture B are mixed and stirs 20-40 minute, obtain polyhexamethylene guanidine propionate poultry fish drug powder.
(4) polyhexamethylene guanidine propionate poultry fish drug powder is loaded in capsule according to a certain amount of, namely obtains polyhexamethylene guanidine propionate poultry fish medicament capsule.
The processing technique of described medicated feed additive is as follows:
(1), by polyhexamethylene guanidine propionate, synergist and auxiliary U.S. powder stir 20-40 minute according to aforementioned proportion mixing, obtain mixture A;
(2), by corn starch, anhydrous glucose stir 20-40 minute according to aforementioned proportion mixing, obtain mixture B;
(3), according to aforementioned proportion, 20-40 minute is stirred in mixture A, mixture B mixing, obtains polyhexamethylene guanidine propionate medicated feed additive powder;
(4), according to aforementioned proportion, 20-40 minute is stirred in polyhexamethylene guanidine propionate, synergist, acesulfame potassium, pure water mixing, obtains polyhexamethylene guanidine propionate medicated feed additive water preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510696595.3A CN105343122A (en) | 2015-10-26 | 2015-10-26 | Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510696595.3A CN105343122A (en) | 2015-10-26 | 2015-10-26 | Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105343122A true CN105343122A (en) | 2016-02-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510696595.3A Pending CN105343122A (en) | 2015-10-26 | 2015-10-26 | Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105343122A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853369A (en) * | 2016-06-03 | 2016-08-17 | 卫国刚 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653425A (en) * | 2009-09-15 | 2010-02-24 | 山东罗欣药业股份有限公司 | Arbidol hydrochloride medicament composition dispersible tablets and preparation method thereof |
| CN102397555A (en) * | 2011-11-23 | 2012-04-04 | 河南牧翔动物药业有限公司 | Veterinary use soluble powder accessory and preparation method thereof |
| CN103705536A (en) * | 2014-01-03 | 2014-04-09 | 卫望奎 | Pharmaceutical formula of polyhexamethylene guanidine hydrochloride (PHMG) and preparation method |
| CN104839458A (en) * | 2015-06-11 | 2015-08-19 | 卫国刚 | Polyhexamethylene guanidine medicated feed additive |
-
2015
- 2015-10-26 CN CN201510696595.3A patent/CN105343122A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101653425A (en) * | 2009-09-15 | 2010-02-24 | 山东罗欣药业股份有限公司 | Arbidol hydrochloride medicament composition dispersible tablets and preparation method thereof |
| CN102397555A (en) * | 2011-11-23 | 2012-04-04 | 河南牧翔动物药业有限公司 | Veterinary use soluble powder accessory and preparation method thereof |
| CN103705536A (en) * | 2014-01-03 | 2014-04-09 | 卫望奎 | Pharmaceutical formula of polyhexamethylene guanidine hydrochloride (PHMG) and preparation method |
| CN104839458A (en) * | 2015-06-11 | 2015-08-19 | 卫国刚 | Polyhexamethylene guanidine medicated feed additive |
Non-Patent Citations (1)
| Title |
|---|
| 岳荣春等: "《医院消毒技术与应用》", 30 January 2013, 人民军医出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853369A (en) * | 2016-06-03 | 2016-08-17 | 卫国刚 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160224 |