CN105853369A - Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof - Google Patents
Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof Download PDFInfo
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- CN105853369A CN105853369A CN201610389821.8A CN201610389821A CN105853369A CN 105853369 A CN105853369 A CN 105853369A CN 201610389821 A CN201610389821 A CN 201610389821A CN 105853369 A CN105853369 A CN 105853369A
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- Prior art keywords
- polyhexamethylene guanidine
- digestive system
- system infection
- medicine
- starch
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fodder In General (AREA)
Abstract
The invention belongs to the field of drugs, and particularly relates to a polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and a preparing method thereof. The drug is prepared from, by weight, 0.01-30 parts of polyhexamethylene guanidine, 10-90 parts of glucose, 5-20 parts of starch and 5-20 parts of anhydrous sodium sulfate. The polyhexamethylene guanidine drug has the advantages that the provided polyhexamethylene guanidine drug and a drug feed additive for treating livestock, poultry and fish digestive system infection can take effect fast and directly, absorption, residual, toxic and side effects and drug resistance are avoided, and the drug does not pollute the environment.
Description
Technical field
The invention belongs to drug world, be specifically related to a kind of poly-six methylenes treating poultry fish digestive system infection
Base guanidine medicine and preparation method thereof.
Background technology
At present, poultry fish medicine and the medicated feed additive for the treatment of poultry fish digestive system infection mostly is antibiosis
Element, example hydrochloric acid ciprofloxacin, Norfloxacin Lactate, enrofloxacin, amoxicillin etc..Fish makes poultry for a long time
With antibiotic, not only increase the Drug resistance of pathogenic bacteria, and cause antibiotic to exceed standard.The residual of antibiotic is not
Only directly poultry fish is produced acute toxicity and chronic toxicity effect, also by the effect of environment and food chain indirectly to human body
Health causes potential hazard, simultaneously to environment.
Polyhexamethylene guanidine is environment-friendly type macromolecule polymer, soluble in water；Aqueous solution is nontoxic, colourless, nothing
Smell；Do not fire, the most quick-fried；There is an extremely strong ability killing antibacterial, and wide spectrum, efficiently and have and press down for a long time
Bacterium effect；To various materials without erosion；Non-corrosiveness；Without harmful substances such as iodine, chlorine, aldehyde；?
Industrial, agriculture, medical and daily life there is purposes the most widely.The most also do not report use at present
In treatment poultry fish digestive system infection disease.
Summary of the invention
In order to solve the problems referred to above that prior art exists, the invention provides one and treat poultry fish Digestive
Polyhexamethylene guanidine medicine of togetherness dye and preparation method thereof.Polyhexamethylene guanidine is used for treat poultry fish disappear
Change system infections disease, it is possible to treatment poultry colibacillosis, bacterial diarrhea, avian typhoid, paratyphoid fever,
The diseases such as fowl cholera, Pullorum Disease, yellow scour of piglet, Hakuri, fish bacterial disease.
The technical solution adopted in the present invention is:
A kind of polyhexamethylene guanidine medicine treating poultry fish digestive system infection, former including following weight portion
Material is prepared from: 0.01-30 part polyhexamethylene guanidine, 10-90 part glucose, 5-20 part starch and 5-20 part
Auxiliary U.S. powder.The polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection can be single as medicine
Solely use；As medicated feed additive, can also add in the feedstuff of poultry fish, be used for preventing and controlling
Treat poultry fish digestive system infection.
Further, the polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection includes following weight
Amount part raw material be prepared from: 0.1-20 part polyhexamethylene guanidine, 40-80 part glucose, 8-15 part starch and
The auxiliary U.S. powder of 8-15 part.
Further, the polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection includes following weight
The raw material of amount part is prepared from: 16 parts of polyhexamethylene guanidines, 60 parts of glucoses, 12 parts of starch and 12 parts are auxiliary
U.S. powder.
Further, described polyhexamethylene guanidine includes poly-six methylenes of gluconic acid polyhexamethylene guanidine, lactic acid
A kind of or the combination of at least two in base guanidine, sulphuric acid polyhexamethylene guanidine and phosphoric acid polyhexamethylene guanidine.
Further, described polyhexamethylene guanidine be grape saccharic acid polyhexamethylene guanidine, lactic acid polyhexamethylene guanidine,
The mixing that sulphuric acid polyhexamethylene guanidine and phosphoric acid polyhexamethylene guanidine form according to mass ratio 1-5:1-5:1-5:1-5
Thing.
Further, during described starch is corn starch, potato starch, wheaten starch, Lotus Root Starch
A kind of or the combination of at least two.Described glucose is anhydrous glucose；Anhydrous glucose is nutritional drugs, for
Organic compound, the i.e. glucose without water of crystallization.For colourless crystallization or white crystalline powder, odorless,
Taste is sweet, readily soluble in water, slightly soluble in ethanol.
Auxiliary U.S. powder is up-to-date water-solubility carrier, can be used for producing the water soluble drug of various class, good water solubility,
Clarity is high, can make water solube powder；There are stronger adsorptivity and affinity, there is sustained-release synergistic effect.
A kind of preparation method of the polyhexamethylene guanidine medicine of above-mentioned treatment poultry fish digestive system infection, bag
Include following steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with auxiliary U.S. powder, stirs, obtain the first mixture；
Step 2, described first mixture is sufficiently mixed with starch, stirs, obtain the second mixture；
Step 3, described second mixture is sufficiently mixed with glucose, stirs, obtain described treatment
The polyhexamethylene guanidine medicine of poultry fish digestive system infection.
In above-mentioned steps 3, the polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection is all right
It is referred to as polyhexamethylene guanidine medicated feed additive, adds in the feedstuff of poultry fish, be used for preventing and treating
Poultry fish digestive system infection.Gained treatment poultry fish digestive system infection polyhexamethylene guanidine medicine or
Medicated feed additive is powder, and the particle diameter of described powder is 80-200 mesh.Or described powder medicaments is permissible
Carry out pelletize, be dried afterwards, obtain drug particles；Described dry temperature is 60-80 DEG C, and the time is
1-2 hour；Drug particles then can make capsule or tablet.
Further, polyhexamethylene guanidine medicine or the medicine of described treatment poultry fish digestive system infection is raised
Feed additives can also is that water preparation, and the raw material including following weight portion is prepared from: poly-six methylenes of 0.01-30 part
Base guanidine, 0.01-20 part synergist, 0.01-0.4 part acesulfame potassium and 50-99 part pure water.
Its preparation method comprises the steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with synergist, stirs, obtain the first mixture；
Step 2, acesulfame potassium and pure water are sufficiently mixed, stir, obtain the second mixture；
Step 3, described first mixture, described second mixture are sufficiently mixed, stir, obtain
The polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection or medicated feed additive.
Further, the described polyhexamethylene guanidine medicine treating poultry fish digestive system infection and pharmaceutical feed
Additive can be with form of therapy poultry fish digestive system infection diseases such as liquid water preparation, powder, capsule and tablets
Sick.The time of stirring described in above-mentioned steps is 20-60min.
The invention have the benefit that poly-six methylenes treating poultry fish digestive system infection that the present invention provides
Base guanidine medicine and medicated feed additive, using polyhexamethylene guanidine as main pharmacodynamics composition, polyhexamethylene
Guanidine is not absorbed by cells in vivo, and is again antibacterial；And poultry fish digestive system disease also many by antibacterial,
Virus infects and causes, so polyhexamethylene guanidine composition, both can play therapeutical effect, and not by the intestines and stomach
Road is absorbed, and will not develop immunity to drugs, and does not has any toxic and side effects.By " bactericidal properties " of polyhexamethylene guanidine
" do not absorb " characteristic to combine dexterously, and coordinate interpolation glucose, starch, auxiliary U.S. powder, potentiation
Agent and acesulfame potassium auxiliary element, obtain the polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection
Feed additive, can effectively suppress antibacterial, fungus, the splitting function of virus, make antibacterial, fungus, disease
Poison loses reproductive performance, adds the thin film that polymer is formed, and plugs antibacterial, fungus, the breathing of virus
Passage, makes antibacterial, fungus, virus be choked to death rapidly.Its special sterilization mechanism, to each bacterioid,
Fungus, virus do not develop immunity to drugs, and bactericidal effect is not affected by antibacterial, fungus, virus variation,
The entrance of this medicine is internal not to be absorbed by cell, is expelled directly out external, has no side effect after stomach, intestinal.
In sum, the present invention provide treatment poultry fish digestive system infection polyhexamethylene guanidine medicine and
Medicated feed additive has the advantage that
1, can directly onset of action fast；Medicine directly interacts, by positive and negative with pathogenic bacteria after entering the intestines and stomach
Electric charge attracts each other and is wound around and wraps up pathogenic bacteria, cuts off pathogenic bacteria nutrient absorption passage and also suppresses it to divide, makes disease
Bacterium is choked to death.Other similar drugs substantially participate in cellular metabolism and upset or check metabolic pathway and reach
To sterilization purpose.
2, do not absorb and do not remain, have no side effect；Its effective ingredient is macromolecule polyalcohol, after entering the intestines and stomach
Will not be absorbed by digested pipe mucomembranous epithelial cell, directly excreted with stool form by large intestine, to poultry
Fowl fish is had no side effect, also indirectly will not be worked the mischief human body by food chain.Other similar drugs then can
Blood and lymph fluid is entered through digestive tube mucomembranous epithelial cell, widely distributed and residue in each tissue, body fluid
In, such as liver, kidney, lung, prostate, testis, uterus and bile, sputum, vesicle liquid, blood, urine etc..
3, without Drug resistance；Described medicine can wrap up pathogenic bacteria suppression division makes it be choked to death, and has uniqueness
Kill pathogenic bacteria principle so that it is without Drug resistance, long-term taking effect does not subtracts.
4, free from environmental pollution；Described medicine is finally degraded to carbon dioxide, water in nature；Nitrogen element leads to
Generated nitrate by nitrobacteria effect in Chang Shui or in layer of sand, become the nutrient being absorbed and used by plants
Matter, therefore, degradation product environmentally safe.
Detailed description of the invention
Embodiment 1
The invention provides a kind of polyhexamethylene guanidine pharmaceutical feed treating poultry fish digestive system infection to add
Agent, the raw material including following weight portion is prepared from: 4 parts of polyhexamethylene guanidines, 80 parts of glucoses, 8 parts
Starch and 8 parts of auxiliary U.S. powder.
Its preparation method comprises the steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with auxiliary U.S. powder, stirs, obtain the first mixture；
Step 2, described first mixture is sufficiently mixed with starch, stirs, obtain the second mixture；
Step 3, described second mixture is sufficiently mixed with glucose, stirs, obtain described treatment
The polyhexamethylene guanidine medicine of poultry fish digestive system infection.
Embodiment 2
The invention provides a kind of polyhexamethylene guanidine pharmaceutical feed treating poultry fish digestive system infection to add
Agent, the raw material including following weight portion is prepared from: 20 parts of polyhexamethylene guanidines, 40 parts of glucoses, 15
Part starch and 15 parts of auxiliary U.S. powder.
Its preparation method comprises the steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with auxiliary U.S. powder, stirs, obtain the first mixture；
Step 2, described first mixture is sufficiently mixed with starch, stirs, obtain the second mixture；
Step 3, described second mixture is sufficiently mixed with glucose, stirs, obtain drug powder,
Carry out pelletize afterwards, be dried, obtain the polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection
Feed additive.Baking temperature is 80 DEG C, and the time is 1 hour.
Embodiment 3
The invention provides a kind of polyhexamethylene guanidine pharmaceutical feed treating poultry fish digestive system infection to add
Agent, the raw material including following weight portion is prepared from: 3 parts of polyhexamethylene guanidines, 3 parts of synergists, 0.2 part
Acesulfame potassium and 93.8 parts of pure water.
Its preparation method comprises the steps:
Step 1, polyhexamethylene guanidine, synergist are sufficiently mixed, stir, obtain the first mixture；
Step 2, acesulfame potassium is sufficiently mixed with pure water, stirs, obtain the second mixture；
Step 3, described first mixture, described second mixture are sufficiently mixed, stir, obtain
The polyhexamethylene guanidine medicated feed additive of described treatment poultry fish digestive system infection.
Embodiment 4
The invention provides a kind of polyhexamethylene guanidine medicine treating poultry fish digestive system infection, including such as
The raw material of lower weight portion is prepared from: 16 parts of polyhexamethylene guanidines, 60 parts of glucoses, 12 parts of starch and 12
The auxiliary U.S. powder of part.
Its preparation method comprises the steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with auxiliary U.S. powder, stirs, obtain the first mixture；
Step 2, described first mixture is sufficiently mixed with starch, stirs, obtain the second mixture；
Step 3, described second mixture is sufficiently mixed with glucose, stirs, obtain drug powder,
Carry out pelletize afterwards, be dried, obtain the polyhexamethylene guanidine medicine of described treatment poultry fish digestive system infection.
Baking temperature is 60 DEG C, and the time is 2 hours.
Embodiment 5
The invention provides a kind of polyhexamethylene guanidine medicine treating poultry fish digestive system infection, including such as
The raw material of lower weight portion is prepared from: 30 parts of polyhexamethylene guanidines, 60 parts of glucoses, 5 parts of starch and 5 parts
Auxiliary U.S. powder.
Its preparation method comprises the steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with auxiliary U.S. powder, stirs, obtain the first mixture；
Step 2, described first mixture is sufficiently mixed with starch, stirs, obtain the second mixture；
Step 3, described second mixture is sufficiently mixed with glucose, stirs, obtain described treatment
The polyhexamethylene guanidine medicine of poultry fish digestive system infection.
The present invention is by carrying out poly-six methylenes to the poultry of 1000 digestive system infections of certain fowl and livestock farm
Base guanidine medicated feed additive feeding, the treatment poultry fish that adding the embodiment of the present invention 1 in feedstuff provides disappears
Change the polyhexamethylene guanidine medicated feed additive of system infections, once a day, each 1-2g.Clinical symptoms
It is wholly absent, for recovery from illness；Clinical symptoms is clearly better, for effectively；Clinical symptoms does not has significant change or tight
Weight, for invalid.
Observed result, 809 examples of wherein fully recovering, effective 181 examples, invalid 10 examples, the treatment that the present invention provides
The polyhexamethylene guanidine medicated feed additive total effective rate of poultry fish digestive system infection is 99%.Therefore,
The polyhexamethylene guanidine medicine of the treatment poultry fish digestive system infection that the present invention provides and medicated feed additive
Can directly onset of action fast；Do not absorb and do not remain, have no side effect；Without Drug resistance, free from environmental pollution.
The present invention is not limited to above-mentioned preferred forms, and anyone can draw it under the enlightenment of the present invention
His various forms of products, no matter but on its formula or component, make any change, every have and the application
Technical scheme as same or like, within all falling within protection scope of the present invention.
Claims (8)
1. the polyhexamethylene guanidine medicine treating poultry fish digestive system infection, it is characterised in that: bag
The raw material including following weight portion is prepared from: 0.01-30 part polyhexamethylene guanidine, 10-90 part glucose, 5-20
Part starch and the auxiliary U.S. powder of 5-20 part.
The polyhexamethylene guanidine medicine for the treatment of poultry fish digestive system infection the most according to claim 1,
It is characterized in that: include that the raw material of following weight portion is prepared from: 0.1-20 part polyhexamethylene guanidine, 40-80
The auxiliary U.S. powder of part glucose, 8-15 part starch and 8-15 part.
The polyhexamethylene guanidine medicine for the treatment of poultry fish digestive system infection the most according to claim 1,
It is characterized in that: include that the raw material of following weight portion is prepared from: 16 portions of polyhexamethylene guanidines, 60 portions of Fructus Vitis viniferaes
The auxiliary U.S. powder of sugar, 12 parts of starch and 12 parts.
The polyhexamethylene guanidine medicine for the treatment of poultry fish digestive system infection the most according to claim 1,
It is characterized in that: described polyhexamethylene guanidine includes gluconic acid polyhexamethylene guanidine, lactic acid polyhexamethylene
A kind of or the combination of at least two in guanidine, sulphuric acid polyhexamethylene guanidine and phosphoric acid polyhexamethylene guanidine.
The polyhexamethylene guanidine medicine for the treatment of poultry fish digestive system infection the most according to claim 1,
It is characterized in that: described polyhexamethylene guanidine be grape saccharic acid polyhexamethylene guanidine, lactic acid polyhexamethylene guanidine,
The mixing that sulphuric acid polyhexamethylene guanidine and phosphoric acid polyhexamethylene guanidine form according to mass ratio 1-5:1-5:1-5:1-5
Thing.
The polyhexamethylene guanidine medicine for the treatment of poultry fish digestive system infection the most according to claim 1,
It is characterized in that: described starch is in corn starch, potato starch, wheaten starch, Lotus Root Starch
Plant or the combination of at least two.
7. the polyhexamethylene guanidine medicine of the arbitrary described treatment poultry fish digestive system infection of claim 1-6
The preparation method of thing, it is characterised in that: comprise the steps:
Step 1, polyhexamethylene guanidine is sufficiently mixed with auxiliary U.S. powder, stirs, obtain the first mixing
Thing；
Step 2, described first mixture is sufficiently mixed with starch, stirs, obtain the second mixing
Thing；
Step 3, described second mixture is sufficiently mixed with glucose, stirs, obtain described in control
Treat the polyhexamethylene guanidine medicine of poultry fish digestive system infection.
The polyhexamethylene guanidine medicine for the treatment of poultry fish digestive system infection the most according to claim 7
Preparation method, it is characterised in that: described in above-mentioned steps stirring time be 20-60min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610389821.8A CN105853369A (en) | 2016-06-03 | 2016-06-03 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610389821.8A CN105853369A (en) | 2016-06-03 | 2016-06-03 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
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| CN105853369A true CN105853369A (en) | 2016-08-17 |
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| CN201610389821.8A Pending CN105853369A (en) | 2016-06-03 | 2016-06-03 | Polyhexamethylene guanidine drug for treating livestock, poultry and fish digestive system infection and preparing method thereof |
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Citations (5)
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|---|---|---|---|---|
| US20030232087A1 (en) * | 2002-06-18 | 2003-12-18 | Lawin Laurie R. | Bioactive agent release coating with aromatic poly(meth)acrylates |
| CN102247386A (en) * | 2011-05-26 | 2011-11-23 | 河南牧翔动物药业有限公司 | Soluble powder used for treating poultry coccidiosis |
| CN105030684A (en) * | 2015-07-20 | 2015-11-11 | 卫国刚 | Formula for polyhexamethylene guanidine medicine powder and capsules and method for preparing same |
| CN105125574A (en) * | 2015-07-20 | 2015-12-09 | 卫国刚 | Formula and preparation process of polyhexamethylene guanidine drug powder for beasts and birds |
| CN105343122A (en) * | 2015-10-26 | 2016-02-24 | 卫国刚 | Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation |
-
2016
- 2016-06-03 CN CN201610389821.8A patent/CN105853369A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030232087A1 (en) * | 2002-06-18 | 2003-12-18 | Lawin Laurie R. | Bioactive agent release coating with aromatic poly(meth)acrylates |
| CN102247386A (en) * | 2011-05-26 | 2011-11-23 | 河南牧翔动物药业有限公司 | Soluble powder used for treating poultry coccidiosis |
| CN105030684A (en) * | 2015-07-20 | 2015-11-11 | 卫国刚 | Formula for polyhexamethylene guanidine medicine powder and capsules and method for preparing same |
| CN105125574A (en) * | 2015-07-20 | 2015-12-09 | 卫国刚 | Formula and preparation process of polyhexamethylene guanidine drug powder for beasts and birds |
| CN105343122A (en) * | 2015-10-26 | 2016-02-24 | 卫国刚 | Propanoic acid polyhexamethylene guanidine livestock, poultry and fish pharmaceutical preparation |
Non-Patent Citations (2)
| Title |
|---|
| 林立旺，等: "一种复方聚六亚甲基胍消毒液的配方筛选及杀菌效果研究", 《中国消毒学杂志》 * |
| 黄新宇: "盐酸聚六亚甲基胍消毒剂研究进展", 《中国卫生工程学》 * |
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Application publication date: 20160817 |