CN105343097A - Composition containing caffeine and application and manufacturing method of composition containing caffeine - Google Patents

Composition containing caffeine and application and manufacturing method of composition containing caffeine Download PDF

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Publication number
CN105343097A
CN105343097A CN201510613001.8A CN201510613001A CN105343097A CN 105343097 A CN105343097 A CN 105343097A CN 201510613001 A CN201510613001 A CN 201510613001A CN 105343097 A CN105343097 A CN 105343097A
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China
Prior art keywords
caffeine
containing caffeine
compositions containing
compound
solution
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CN201510613001.8A
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Chinese (zh)
Inventor
李东旭
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Tianjin Jianlaide Technology Co Ltd
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Tianjin Jianlaide Technology Co Ltd
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Priority to CN201510613001.8A priority Critical patent/CN105343097A/en
Publication of CN105343097A publication Critical patent/CN105343097A/en
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Abstract

The invention provides a composition containing caffeine, a functional exercise spray with the composition containing the caffeine, a preparation method of the functional exercise spray, a functional exercise kinesio tape formula with the composition containing the caffeine and a preparation method of the functional exercise kinesio tape formula. Effective percutaneous administration of the caffeine can be realized. The composition containing the caffeine is enabled to be absorbed percutaneously by means of the spray and kinesio tapes, evident slow release, long-time supply and the like are realized, and the caffeine absorption and effective utilization rate is maximally higher by more than 400% as compared with that of a traditional caffeine absorption approach that the caffeine is absorbed through a digestive system.

Description

A kind of compositions containing caffeine and application thereof and manufacture method
Technical field
The invention belongs to medicines and health protection, daily use chemicals, sports apparatus technical field, especially relate to a kind of compositions containing caffeine and application thereof and manufacture method.
Background technology
Caffeine is psychoactive compound the most frequently used in the world.Caffeine has the physiology and pharmacological action that comprise direct stimulation and awakening, to the support of cerebral activity, improves cardiovascular endurance, improves metabolic function level.On therapeutic treatment, caffeine is widely used as analgesics and gentle diuretic.
In general, caffeine is oral administration, but oral caffeine has many drawbacks.Such as, caffeine has strong bitterness, and mouthfeel is undesirable often.The taste that existing fluid series products uses the additives such as natural or artificial sweetening agent in a large number to cover caffeine to have.And the additives such as sweeting agent are due to containing a large amount of sugars, can cause fat while absorption caffeine.Oral caffeine, when being absorbed by digestion, has obvious first pass effect, and while increasing the workload of the internal organs such as liver, kidney, the caffeine of mass efficient becomes branch to drain waste thereupon.
The solution that the application process of existing oral caffeine provides increases product monomer content of caffeine, but also there is its limitation, a large amount of caffeine is absorbed while, can content of caffeine in fast lifting human body at short notice, thus nervous system is impacted, when human body content of caffeine falls after rise to normal level, the huge concentration difference in the short time also can bring strong discomfort and feeling of fatigue to human body.Therefore, need a kind of more rationally and be easy to method that health absorbs to provide caffeine.
Summary of the invention
The object of this invention is to provide a kind of compositions containing caffeine and application thereof and manufacture method, solve human body by after functional type sports drink absorption caffeine, poor to the utilizing status of caffeine, run off and cause internal organs load in a large number under the first pass effect of effective ingredient Liver and kidney, caffeine is declined to problems such as neural stimulation and discomforts rapidly by after the concentration short time fast lifting after absorbing in human body.
Technical scheme of the present invention is:
Containing the compositions of caffeine, comprise caffeine, at least one assists caffeine to dissolve and the compound of Transdermal absorption and deionized water.
Further, the described compositions containing caffeine also comprises taurine and/or menthol.
Further, described auxiliary caffeine dissolves and the compound (HE) of Transdermal absorption can be in following composition any one: tryptophan carbethoxy hydrochloride, tryptophan propyl ester hydrochloride, tryptophan isopropyl ester hydrochlorate, tryptophan butanoate hydrochlorate, leucine methyl ester hydrochloride, leucine isopropyl ester hydrochlorate, Isoleucine methyl ester hydrochlorate, isoleucine isopropyl ester hydrochlorate, tyrosine propyl ester hydrochloride, tyrosine isopropyl ester hydrochlorate, phenylalanine methyl ester hydrochloride, phenylalanine isopropyl ester hydrochlorate, proline methyl ester hydrochloride, proline isopropyl ester hydrochlorate.
Another aspect of the present invention, a kind of auxiliary caffeine dissolves and the method for the compound of Transdermal absorption, comprises the following steps:
(1) a kind of L or the D-aminoacid in tryptophan, leucine, isoleucine, tyrosine, phenylalanine, proline is dissolved in alcohol solution;
(2) HCl gas is passed in the mixed solution of aminoacid that step (1) obtains and alcohol;
(3) solution after mixing hydrochloric acid step (2) obtained stablizes stirring 48 hours in 50 degrees Celsius;
Open bottleneck after (4) 48 hours and continue stirring until room temperature;
(5) will add in bottle inlet with mutually commensurability alcoholic solution in step (2), reheat to 50 degree and Keep agitation 24 hours;
Open bottleneck after (6) 24 hours and continue stirring until room temperature;
(7) acetate is added after also stirring in bottle inlet, filter and obtain compound;
(8) compound obtained after filtering puts into 50 degrees Celsius of drying in oven.
Another aspect of the present invention, a kind of functional exercise spray solution of the compositions containing caffeine, comprises caffeine, at least one assists caffeine to dissolve and the compound of Transdermal absorption and deionized water.
The functional exercise spray solution of compositions containing caffeine, comprises caffeine, at least one assists caffeine to dissolve and the compound of Transdermal absorption, deionized water, taurine and/or menthol.
As shown in Figure 1, A is the spray action effect not adding auxiliary caffeine absorption composition; B-O is the spray action effect of HE as auxiliary caffeine absorption composition.
Another aspect of the present invention, a kind of kinesiology tape of the compositions containing caffeine, the described compositions containing caffeine is caffeine, at least one assists caffeine to dissolve and compound, the deionized water of Transdermal absorption.
A kinesiology tape for compositions containing caffeine, the described compositions containing caffeine is caffeine, at least one assists caffeine to dissolve and the compound of Transdermal absorption, deionized water, taurine and/or menthol.
Another aspect of the present invention, a kind of functional exercise spray of the compositions containing caffeine, described spray forms by with lower part: the solution of spraying bottle, compositions containing caffeine.
Another aspect of the present invention, a kind of kinesiology tape of the compositions containing caffeine, described kinesiology tape forms by with lower part: solution, the release paper of basic fabric, medical acrylic acid pressure-sensitive glue, compositions containing caffeine.
Further, in the functional exercise spray solution of the described compositions containing caffeine and/or the kinesiology tape of the described compositions containing caffeine, in the solution of the described compositions containing caffeine caffeine by weight percentage scope be 1% ~ 20%, 2% ~ 12%, 3% ~ 10%, 4% ~ 7%.
Further, in the functional exercise spray solution of the described compositions containing caffeine and/or the kinesiology tape of the described compositions containing caffeine, in the solution of the described compositions containing caffeine a kind of auxiliary caffeine dissolve and the compound (HE) of Transdermal absorption by weight percentage scope be 1% ~ 50%, 2% ~ 25%, 3% ~ 10%, 4% ~ 7%.
Further; in the functional exercise spray solution of the described compositions containing caffeine and/or the kinesiology tape of the described compositions containing caffeine; in the solution of the described compositions containing caffeine taurine by weight percentage scope be 1% ~ 20%; 2% ~ 12%; 3% ~ 10%, 4% ~ 7%.
Further, in the functional exercise spray solution of the described compositions containing caffeine and/or the kinesiology tape of the described compositions containing caffeine, in the solution of the described compositions containing caffeine menthol by weight percentage scope be 0.01% ~ 20%, 0.1% ~ 10%, 1% ~ 5%, 1% ~ 3%.
Further, in the functional exercise spray solution of the described compositions containing caffeine and/or the kinesiology tape of the described compositions containing caffeine, in the solution of the described compositions containing caffeine deionized water by weight percentage scope be 1% ~ 97%, 50% ~ 95%, 70% ~ 90%, 75% ~ 88%.
Another aspect of the present invention, a kind of preparation method of functional exercise spray of the compositions containing caffeine, described spray is made through aseptic canning in purification production space.
Another aspect of the present invention, a kind of preparation method of kinesiology tape of the compositions containing caffeine, is characterized in that comprising the following steps:
Step 1: described ingredient comprises solution, the release paper of tool basic fabric springy, medical acrylic acid pressure-sensitive glue, compositions containing caffeine;
Step 2: the composition solution containing caffeine is mixed with medical pressure-sensing glue and stirs;
Step 3: the kinesiology tape obtaining the compositions containing caffeine according to the sequentially built of gluing-drying glue-compound-oven dry-rolling-cut-pack.
Further, the value of elastic of described tool basic fabric springy is greater than 1:1.6.
Further, in described step 2, the composition solution containing caffeine is fully stirred with medical pressure-sensing glue the medical pressure-sensing glue forming the compositions containing caffeine of mixing homogeneously according to the ratio of 1:100 ~ 8:100.
Further, the concrete steps of described step 3 are:
A. gluing; By the medical pressure-sensing glue uniform application of the compositions containing caffeine in the one side of release paper with antitack agent;
B. drying glue; To the release paper of glue be scribbled by hot blast drying tunnel, dry the moisture content in the medical pressure-sensing glue of the compositions containing caffeine of going about 70% ~ 90%;
C. compound; By through release paper and the elastic fabric compound under stress of the medical pressure-sensing glue with the compositions containing caffeine of drying tunnel, make fabric and release paper completely closely sealed, fabric maintenance naturalness, smooth and do not stretch;
D. dry; Product after compound is put into drying tunnel again, and drying tunnel temperature keeps 80 DEG C ~ 100 DEG C, is the highlyest no more than 130 DEG C, and volatilize unnecessary moisture content;
E. rolling; The product harvest volume that moisture content has been volatilized;
F. cut; The product of rolling is cut into required size;
G. pack.
Further, in the b of described step 3, the initial drying glue temperature of drying tunnel is not higher than 80 DEG C, and promote temperature step by step in order afterwards, final section drying tunnel temperature is no more than 120 DEG C.
The advantage that the present invention has and good effect are: the compositions containing caffeine is absorbed through skin by the mode of spray, kinesiology tape by formula described in the invention, there is the advantage such as obvious slow releasing, long-time supply, and the absorption of caffeine and effective rate of utilization are compared and traditional are exceeded the highest by more than 400% by the assimilation effect of digestive system.
Accompanying drawing explanation
Content of caffeine curve chart in the blood plasma that Fig. 1 obtains for assay method of the present invention.
Detailed description of the invention
Embodiment 1:
A kind of preparation method of the functional exercise spray solvent containing caffeine is carried out according to the following steps:
Step 1: make a kind of auxiliary caffeine and dissolve and the compound of Transdermal absorption; In 10 litre flasks, 1 kilogram of (kg) L or D-aminoacid (tryptophan, leucine, isoleucine, tyrosine, phenylalanine, proline) is dissolved in 5 liters of (L) alcohols (methanol, ethanol, propanol, isopropyl alcohol, butanols) solution.350 grams of (g) hydrochloric acid (HCl) gases are passed in the mixed solution of aminoacid and alcohol.Solution after mixing hydrochloric acid stablizes stirring 48 hours in 50 degrees Celsius.Open bottleneck after 48 hours and continue stirring until room temperature.4 liters (L) alcoholic solution is as hereinbefore added in bottle inlet, reheats to 50 degree also Keep agitation 24 hours.Open bottleneck after 24 hours and continue stirring until room temperature.Being added 3 liters of acetates in bottle inlets and after stirring, filter and obtain compound, in bottle, remaining residue again can add 3 liters of acetates and stirs rear and filter.The compound obtained after filtration puts into 50 degrees Celsius of drying in oven.
Step 2: solution makes; The compound and the deionized water that a kind of auxiliary caffeine are dissolved also Transdermal absorption are mixed to uniform dissolution.To add in caffeine and/or taurine, menthol to mixed liquor and Keep agitation number minute.
Step 3: make canned through sterile working for above-mentioned solution to spray in purification production space.
Embodiment 2:
The kinesiology tape of a kind of compositions containing caffeine described in the present invention is achieved through the following technical solutions:
Step 1: prepare the raw material making kinesiology tape ingredient, comprises solution, the release paper of tool basic fabric springy, medical acrylic acid pressure-sensitive glue, compositions containing caffeine;
Step 2: the composition solution containing caffeine is mixed with medical pressure-sensing glue and stirs;
Step 3: the kinesiology tape making the compositions containing caffeine:
A. gluing; The medical pressure-sensing glue uniform application of the compositions containing caffeine there is the one side of antitack agent in release paper; In order to provide stronger breathability and cohesive, during gluing, different types of technological means can be adopted, such as, on coated face, mark shape wave striped with pectination sawtooth mould, or use the mould with figure stricture of vagina to extrude texture on coated face.
B. drying glue; To the release paper of glue be scribbled by hot blast drying tunnel, dry the moisture content in the medical pressure-sensing glue of the compositions containing caffeine of going about 70% ~ 90%; The initial drying glue temperature of drying tunnel is not higher than 80, and promote temperature step by step in order afterwards, final section drying tunnel temperature is no more than 120.
C. compound; By through release paper and the elastic fabric compound under stress of the medical pressure-sensing glue with the compositions containing caffeine of drying tunnel, make fabric and release paper completely closely sealed, fabric maintenance naturalness, smooth and do not stretch;
D. dry; Product after compound is put into drying tunnel again, and drying tunnel temperature keeps 80 ~ 100, is the highlyest no more than 130, and volatilize unnecessary moisture content;
E. rolling; The product harvest volume that moisture content has been volatilized;
F. cut; The product of rolling is cut into required size;
G. pack.
Embodiment 3:
A kind of manufacture method of the functional exercise spray containing caffeine
Step 1: by caffeine, tyrosine isopropyl ester hydrochlorate, deionized water, taurine, menthol by following part by weight mix homogeneously:
Step 2: in cleaning shop, above-mentioned solution is made in sterile working's fill to spraying bottle.
Embodiment 4:
A kind of manufacture method of the functional exercise spray containing caffeine
Step 1: by caffeine, tyrosine isopropyl ester hydrochlorate, deionized water, taurine, menthol by following part by weight mix homogeneously:
Step 2: in cleaning shop, above-mentioned solution is made in sterile working's fill to spraying bottle.
Embodiment 5:
A kind of manufacture method of the functional exercise spray containing caffeine
Step 1: by caffeine, tyrosine isopropyl ester hydrochlorate, deionized water by following part by weight mix homogeneously.
Caffeine 80 grams
Tyrosine isopropyl ester hydrochlorate 100 grams
Deionized water 1000 grams
Step 2: in cleaning shop, above-mentioned solution is made in sterile working's fill to spraying bottle.
Embodiment 6:
A kind of manufacture method of the functional exercise spray containing caffeine
Step 1: by caffeine, tyrosine isopropyl ester hydrochlorate, deionized water, menthol by following part by weight mix homogeneously.
Step 2: in cleaning shop, above-mentioned solution is made in sterile working's fill to spraying bottle.
Embodiment 7:
A kind of manufacture method of the functional exercise spray containing caffeine
Step 1: by caffeine, tryptophan isopropyl ester hydrochlorate, deionized water, taurine, menthol by following part by weight mix homogeneously.
Step 2: in cleaning shop, above-mentioned solution is made in sterile working's fill to spraying bottle.
Embodiment 8:
A kind of manufacture method of the kinesiology tape containing caffeine
Step 1: by caffeine, tryptophan isopropyl ester hydrochlorate, deionized water, menthol by following part by weight mix homogeneously.
Step 2: by above-mentioned solution and medical acrylate pressure-sensitive glue according to part by weight 6:100 mixing and stirring.
Step 3: obtain the kinesiology tape containing caffeine according to the sequentially built of gluing-drying glue-compound-oven dry-rolling-cut-pack.
Above one embodiment of the present of invention have been described in detail, but described content being only preferred embodiment of the present invention, can not being considered to for limiting practical range of the present invention.All equalizations done according to the present patent application scope change and improve, and all should still belong within patent covering scope of the present invention.

Claims (18)

1. containing the compositions of caffeine, it is characterized in that: comprise caffeine and at least one assists caffeine to dissolve and compound, the deionized water of Transdermal absorption.
2. the compositions containing caffeine according to claim 1, is characterized in that: also comprise taurine and/or menthol.
3. the compositions containing caffeine according to claim 1 and 2, described auxiliary caffeine dissolves and the compound of Transdermal absorption is tryptophan carbethoxy hydrochloride, tryptophan propyl ester hydrochloride, tryptophan isopropyl ester hydrochlorate, tryptophan butanoate hydrochlorate, leucine methyl ester hydrochloride, leucine isopropyl ester hydrochlorate, Isoleucine methyl ester hydrochlorate, isoleucine isopropyl ester hydrochlorate, tyrosine propyl ester hydrochloride, tyrosine isopropyl ester hydrochlorate, phenylalanine methyl ester hydrochloride, phenylalanine isopropyl ester hydrochlorate, proline methyl ester hydrochloride, one in proline isopropyl ester hydrochlorate.
4. prepare auxiliary caffeine as claimed in claim 1 to dissolve and a method for the compound of Transdermal absorption, comprise the following steps:
(1) a kind of L or the D-aminoacid in tryptophan, leucine, isoleucine, tyrosine, phenylalanine, proline is dissolved in alcohol solution;
(2) HCl gas is passed in the mixed solution of aminoacid that step (1) obtains and alcohol;
(3) solution after mixing hydrochloric acid step (2) obtained stablizes stirring 48 hours in 50 degrees Celsius;
Open bottleneck after (4) 48 hours and continue stirring until room temperature;
(5) will add in bottle inlet with mutually commensurability alcoholic solution in step (2), reheat to 50 degree and Keep agitation 24 hours;
Open bottleneck after (6) 24 hours and continue stirring until room temperature;
(7) acetate is added after also stirring in bottle inlet, filter and obtain compound;
(8) compound obtained after filtering puts into 50 degrees Celsius of drying in oven.
5. a functional exercise spray solution for the compositions containing caffeine, is characterized in that: comprise the compositions containing caffeine as claimed in claim 1 or 2.
6. a functional exercise spray for the compositions containing caffeine, is characterized in that: comprise the compositions and the spraying bottle that contain caffeine as claimed in claim 1 or 2.
7. a kinesiology tape for the compositions containing caffeine, is characterized in that: comprise compositions, basic fabric, medical acrylic acid pressure-sensitive glue, release paper containing caffeine as claimed in claim 1 or 2.
8. the functional exercise spray solution of a kind of compositions containing caffeine according to claim 5 or the kinesiology tape of a kind of compositions containing caffeine according to claim 7, it is characterized in that: in the described composition solution containing caffeine caffeine by weight percentage scope be 1% ~ 20%, 2% ~ 12%, 3% ~ 10%, 4% ~ 7%.
9. the functional exercise spray solution of a kind of compositions containing caffeine according to claim 5 or the kinesiology tape of a kind of compositions containing caffeine according to claim 7, it is characterized in that: in the described composition solution containing caffeine auxiliary caffeine dissolve and the compound of Transdermal absorption by weight percentage scope be 1% ~ 50%, 2% ~ 25%, 3% ~ 10%, 4% ~ 7%.
10. the functional exercise spray solution of a kind of compositions containing caffeine according to claim 5 or the kinesiology tape of a kind of compositions containing caffeine according to claim 7; it is characterized in that: in the described composition solution containing caffeine taurine by weight percentage scope be 1% ~ 20%; 2% ~ 12%; 3% ~ 10%, 4% ~ 7%.
The functional exercise spray solution of 11. a kind of compositionss containing caffeine according to claim 5 or the kinesiology tape of a kind of compositions containing caffeine according to claim 7, it is characterized in that: in the described composition solution containing caffeine menthol by weight percentage scope be 0.01% ~ 20%, 0.1% ~ 10%, 1% ~ 5%, 1% ~ 3%.
The functional exercise spray solution of 12. a kind of compositionss containing caffeine according to claim 5 or the kinesiology tape of a kind of compositions containing caffeine according to claim 7, it is characterized in that: in the described composition solution containing caffeine deionized water by weight percentage scope be 1% ~ 97%, 50% ~ 95%, 70% ~ 90%, 75% ~ 88%.
13. 1 kinds, containing, for example the preparation method of the functional exercise spray of the compositions of the caffeine described in claim 1 or 2, is characterized in that: functional exercise spray as claimed in claim 6, make in purification production space through aseptic canning.
14. 1 kinds, containing the preparation method containing, for example the kinesiology tape of the compositions of the caffeine described in claim 1 or 2, is characterized in that: comprise the following steps:
Step 1: described ingredient comprises solution, the release paper of tool basic fabric springy, medical acrylic acid pressure-sensitive glue, the compositions containing caffeine as claimed in claim 1 or 2;
Step 2: the composition solution containing caffeine is mixed with medical pressure-sensing glue and stirs;
Step 3: the kinesiology tape obtaining the compositions containing caffeine according to the sequentially built of gluing-drying glue-compound-oven dry-rolling-cut-pack.
The preparation method of the kinesiology tape of 15. a kind of compositionss containing caffeine according to claim 14, is characterized in that: the value of elastic of described tool basic fabric springy is greater than 1:1.6.
The preparation method of the kinesiology tape of 16. a kind of compositionss containing caffeine according to claim 14, it is characterized in that: in described step 2, the composition solution containing caffeine is fully stirred with medical pressure-sensing glue the medical pressure-sensing glue forming the compositions containing caffeine of mixing homogeneously according to the ratio of 1:100 ~ 8:100.
The preparation method of the kinesiology tape of 17. a kind of compositionss containing caffeine according to claim 14, is characterized in that: the concrete steps of described step 3 are:
A. gluing; By the medical pressure-sensing glue uniform application of the compositions containing caffeine in the one side of release paper with antitack agent;
B. drying glue; To the release paper of glue be scribbled by hot blast drying tunnel, dry the moisture content in the medical pressure-sensing glue of the compositions containing caffeine of going about 70% ~ 90%;
C. compound; By through release paper and the elastic fabric compound under stress of the medical pressure-sensing glue with the compositions containing caffeine of drying tunnel, make fabric and release paper completely closely sealed, fabric maintenance naturalness, smooth and do not stretch;
D. dry; Product after compound is put into drying tunnel again, and drying tunnel temperature keeps 80 DEG C ~ 100 DEG C, is the highlyest no more than 130 DEG C, and volatilize unnecessary moisture content;
E. rolling; The product harvest volume that moisture content has been volatilized;
F. cut; The product of rolling is cut into required size;
G. pack.
The preparation method of the kinesiology tape of 18. a kind of compositionss containing caffeine according to claim 17, it is characterized in that: in described step b, the initial drying glue temperature of drying tunnel is not higher than 80 DEG C, and promote temperature step by step in order afterwards, final section drying tunnel temperature is no more than 120 DEG C.
CN201510613001.8A 2015-09-24 2015-09-24 Composition containing caffeine and application and manufacturing method of composition containing caffeine Pending CN105343097A (en)

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CN201510613001.8A CN105343097A (en) 2015-09-24 2015-09-24 Composition containing caffeine and application and manufacturing method of composition containing caffeine

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN112618617A (en) * 2021-01-05 2021-04-09 鹤壁市星银凯丰科技有限公司 A patch containing coffee powder and its preparation method

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CN112618617A (en) * 2021-01-05 2021-04-09 鹤壁市星银凯丰科技有限公司 A patch containing coffee powder and its preparation method

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