CN102885881A - Liver heat removing film coated tablet and preparation method thereof - Google Patents
Liver heat removing film coated tablet and preparation method thereof Download PDFInfo
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- CN102885881A CN102885881A CN2012104329803A CN201210432980A CN102885881A CN 102885881 A CN102885881 A CN 102885881A CN 2012104329803 A CN2012104329803 A CN 2012104329803A CN 201210432980 A CN201210432980 A CN 201210432980A CN 102885881 A CN102885881 A CN 102885881A
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- tablet
- qinggan
- film coated
- heat removing
- liver heat
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Abstract
The invention belongs to the technical field of medicines, and discloses a liver heat removing film coated tablet and a preparation method thereof. The liver heat removing film coated tablet is a liver heat removing tablet which is formed by spraying an alcohol-soluble film coating material on the surface of a liver heat removing plain tablet. The method for producing the liver heat removing film coated tablet comprises three technological processes of liquid mixing, preheating and spraying. Compared with a liver heat removing tablet in the prior art, the liver heat removing film coated tablet which is prepared through the method has the following advantages that less auxiliary materials are used, so that the cost is lowered; broken tablets are reduced, the yield is increased, and the production time is greatly shortened; the tablet appearance is improved; the tablet has good humidity resistance, and the tablet stability is increased; the tablet dissolution rate is increased, so that the tablet is quickly disintegrated and has rapid-onset property, and the bioavailability and clinical effects are improved; the bad smell of the tablet is covered up; and the liver heat removing film coated tablet is suitable for most people including diabetic patients.
Description
The invention belongs to field of pharmaceutical technology, relate generally to a kind of Qinggan Tablet Film coated tablets and preparation method thereof.
Background technology
The Qinggan Tablet sheet is comprised of Radix Isatidis, Herba Artemisiae Scopariae, Radix Glycyrrhizae three flavor Chinese medicines, has heat-clearing and toxic substances removing, the dehumidifying function of gallbladder promoting.Be used for cold, fever, laryngopharynx swelling and pain, parotitis, jaundice due to damp-heat.The commercially available prod is coated tablet substantially at present, and according to market sale and patient's feedback opinion, coated tablet is because containing sugar, make some patients were especially diabetics take inconvenience, and coated tablet uses a large amount of adjuvant Pulvis Talci, sucrose in process of production, and the production cycle is long, and product easily goes mouldy, sliver etc.In recent years, Film coated tablets has become the direction of tablet medicament development, is subject to patient's approval.But the launch that up to the present, does not also have the Qinggan Tablet Film coated tablets on the market.
Summary of the invention
For solving the problems of the technologies described above, the objective of the invention is a kind of Qinggan Tablet Film coated tablets and preparation method thereof.
The present invention adopts following technical scheme for finishing above-mentioned purpose:
A kind of Qinggan Tablet Film coated tablets, described Qinggan Tablet Film coated tablets refer to apply the formed Qinggan Tablet tablet of pure molten thin film coating material on the surface of Qinggan Tablet element sheet by mist.
The preparation method for preparing described Qinggan Tablet Film coated tablets, the step of described preparation method is as follows:
(1) with slurry: thin film coating material is placed slurry commanding tank, add ethanol and be mixed with pure molten thin film coating material solution, stir, for subsequent use;
(2) preheating: the Qinggan Tablet element sheet that suppresses is placed seed-coating machine, open hot blast, and rotate main frame, Qinggan Tablet element sheet is rolled in seed-coating machine, temperature is raised to 38～42 ℃ gradually;
(3) spray: regulate spray gun, the pure molten thin film coating material solution that stirs evenly is sprayed on the plain sheet in the rolling, pure molten thin film coating material solution at plain sheet moistened surface, sprawl and condense, until color and luster is even, drying namely makes the Qinggan Tablet Film coated tablets.
During described preparation Qinggan Tablet Film coated tablets, every 100kg Qinggan Tablet element sheet 0.7kg thin film coating material; The amount of solution of used thin film coating material is 7～10kg.
A kind of Qinggan Tablet Film coated tablets that the present invention proposes and preparation method thereof, adopt drug effect and original Qinggan Tablet sheet of the prepared Qinggan Tablet Film coated tablets of above-mentioned preparation method basic identical, but the present invention compares with existing coated tablet, has the following advantages: 1. use adjuvant few, reduced cost; 2. it is broken to have reduced tablet, has improved productive rate, has greatly shortened the production time; 3. improved the mode of appearance of tablet; 4. humidity resistance is good, has increased the stability of medicine; 5. increased the dissolution rate of tablet, made the rapid disintegrate of medicine, rapid-action, improve bioavailability and clinical efficacy; 6. cover the bad smell of medicine; Qinggan Tablet Film coated tablets of the present invention is applicable to extensive crowd, comprises diabetics.
The preparation technology of Qinggan Tablet Film coated tablets of the present invention is simple, and processing ease is easy to grasp, and equipment investment is low, and is with short production cycle, and prepared pharmaceutical properties is stable, guarantees pharmaceutical effectiveness.
Embodiment in conjunction with providing is illustrated the present invention:
A kind of Qinggan Tablet Film coated tablets, described Qinggan Tablet Film coated tablets refer to apply the formed Qinggan Tablet tablet of pure molten thin film coating material on the surface of Qinggan Tablet element sheet by mist.
The preparation method of preparation Qinggan Tablet Film coated tablets, its step is as follows:
(1) with slurry: the thin film coating material of 0.7kg is placed slurry commanding tank, add 95% ethanol 8kg, be mixed with pure molten thin film coating material solution, stir, for subsequent use;
(2) preheating: the Qinggan Tablet element sheet 100kg that suppresses is placed seed-coating machine, open hot blast, and rotate main frame, Qinggan Tablet element sheet is rolled in seed-coating machine, temperature is raised to 38～42 ℃ gradually;
(3) spray: regulate spray gun, the pure molten thin film coating material solution that stirs evenly is sprayed on the plain sheet in the rolling, pure molten thin film coating material solution at plain sheet moistened surface, sprawl and condense, until color and luster is even, drying namely makes Qinggan Tablet Film coated tablets 100.5kg.
During preparation Qinggan Tablet Film coated tablets, every 100kg Qinggan Tablet element sheet 0.7kg thin film coating material; The amount of solution of used thin film coating material is 7～10kg.
Claims (3)
1. Qinggan Tablet Film coated tablets is characterized in that: described Qinggan Tablet Film coated tablets refers to apply the formed Qinggan Tablet tablet of pure molten thin film coating material on the surface of Qinggan Tablet element sheet by mist.
2. prepare the preparation method of the described Qinggan Tablet Film coated tablets of claim 1, it is characterized in that: the step of described preparation method is as follows:
(1) with slurry: thin film coating material is placed slurry commanding tank, add ethanol and be mixed with pure molten thin film coating material solution, stir, for subsequent use;
(2) preheating: the Qinggan Tablet element sheet that suppresses is placed seed-coating machine, open hot blast, and rotate main frame, Qinggan Tablet element sheet is rolled in seed-coating machine, temperature is raised to 38～42 ℃ gradually;
(3) spray: regulate spray gun, the pure molten thin film coating material solution that stirs evenly is sprayed on the plain sheet in the rolling, pure molten thin film coating material solution at plain sheet moistened surface, sprawl and condense, until color and luster is even, drying namely makes the Qinggan Tablet Film coated tablets.
3. Qinggan Tablet Film coated tablets according to claim 1 is characterized in that: during preparation Qinggan Tablet Film coated tablets, and every 100kg Qinggan Tablet element sheet 0.7kg thin film coating material; The amount of solution of used thin film coating material is 7～10kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104329803A CN102885881A (en) | 2012-11-04 | 2012-11-04 | Liver heat removing film coated tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104329803A CN102885881A (en) | 2012-11-04 | 2012-11-04 | Liver heat removing film coated tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102885881A true CN102885881A (en) | 2013-01-23 |
Family
ID=47529699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104329803A Pending CN102885881A (en) | 2012-11-04 | 2012-11-04 | Liver heat removing film coated tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102885881A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417377A (en) * | 2013-08-23 | 2013-12-04 | 九芝堂股份有限公司 | Bronchitis film-coated tablet and preparation method thereof |
| CN109453247A (en) * | 2018-12-06 | 2019-03-12 | 梁金星 | A kind of prevention and treatment four seasons common cold, influenza, the Chinese medicine composition of bird flu, Chinese medical extract and preparation method thereof and dosage form |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706430A (en) * | 2005-05-31 | 2005-12-14 | 贵州英利药业有限公司 | Coated Yankening tablet and its prepn |
-
2012
- 2012-11-04 CN CN2012104329803A patent/CN102885881A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1706430A (en) * | 2005-05-31 | 2005-12-14 | 贵州英利药业有限公司 | Coated Yankening tablet and its prepn |
Non-Patent Citations (2)
| Title |
|---|
| 孙海胜等: "高效包衣机使用含醇薄膜包衣液的安全性分析", 《中国药学杂志》, vol. 38, no. 5, 31 May 2003 (2003-05-31), pages 382 - 383 * |
| 阮群等: "清肝片的质量标准研究", 《时珍国医国药》, vol. 18, no. 1, 31 December 2007 (2007-12-31), pages 140 - 141 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417377A (en) * | 2013-08-23 | 2013-12-04 | 九芝堂股份有限公司 | Bronchitis film-coated tablet and preparation method thereof |
| CN103417377B (en) * | 2013-08-23 | 2019-03-05 | 九芝堂股份有限公司 | Bronchitis piece Film coated tablets and preparation method thereof |
| CN109453247A (en) * | 2018-12-06 | 2019-03-12 | 梁金星 | A kind of prevention and treatment four seasons common cold, influenza, the Chinese medicine composition of bird flu, Chinese medical extract and preparation method thereof and dosage form |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130123 |