CN102885871A - Gentiana scabra bage film coated tablet and method for producing same - Google Patents
Gentiana scabra bage film coated tablet and method for producing same Download PDFInfo
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- CN102885871A CN102885871A CN2012104329837A CN201210432983A CN102885871A CN 102885871 A CN102885871 A CN 102885871A CN 2012104329837 A CN2012104329837 A CN 2012104329837A CN 201210432983 A CN201210432983 A CN 201210432983A CN 102885871 A CN102885871 A CN 102885871A
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- tablet
- radix gentianae
- film coated
- bage
- coating material
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Abstract
The invention belongs to the technical field of medicines, and discloses a gentiana scabra bage film coated tablet and a method for producing the tablet. The gentiana scabra bage film coated tablet is a gentiana scabra bage tablet which is formed by spraying an alcohol-soluble film coating material on the surface of a gentiana scabra bage element tablet. The method for producing the gentiana scabra bage film coated tablet comprises three technological processes of liquid mixing, preheating and spraying. Compared with a gentiana scabra bage sugar-coated tablet in the prior art, the gentiana scabra bage film coated tablet which is prepared by the method has the following advantages that less auxiliary materials are used, so that the cost is lowered; broken tablets are reduced, the yield is increased, and the production time is greatly shortened; the tablet appearance is improved; the tablet has good humidity resistance, and the tablet stability is increased; the tablet dissolution rate is increased, so that the tablet is quickly disintegrated and quickly cures, and the bioavailability and clinical effects are improved; the bad smell of the tablet is covered; and the gentiana scabra bage film coated tablet is suitable for most people including diabetic patients.
Description
Technical field
The invention belongs to field of pharmaceutical technology, relate generally to a kind of Radix Gentianae Film coated tablets and preparation method thereof.
Background technology
Kudancao Tablet is comprised of Herba Taraxaci, Radix Isatidis two flavor Chinese medicines, has the effect of heat-clearing and toxic substances removing, is used for upper respiratory tract infection.Kudancao Tablet is flu class nonprescription drugs medicine, the commercially available prod is coated tablet substantially at present, feedback opinion according to market sale and patient, because the coated tablet of Kudancao Tablet contains sugar, make some patients were especially diabetics take inconvenience, and coated tablet uses a large amount of adjuvants in process of production: Pulvis Talci, sucrose, and the production cycle is long, and product easily goes mouldy, sliver etc.In recent years, Film coated tablets has become the direction of tablet medicament development, is subject to patient's approval.But the launch that up to the present, does not also have the Kudancao Tablet Film coated tablets on the market.
Summary of the invention
For solving the problems of the technologies described above, the objective of the invention is a kind of Radix Gentianae Film coated tablets and preparation method thereof.
The present invention adopts following technical scheme for finishing above-mentioned purpose:
A kind of Radix Gentianae Film coated tablets, described Radix Gentianae Film coated tablets refer to apply the formed Radix Gentianae tablet of pure molten thin film coating material on the surface of Radix Gentianae element sheet by mist.
The preparation method for preparing described Radix Gentianae Film coated tablets, the step of described preparation method is as follows:
(1) with slurry: thin film coating material is placed slurry commanding tank, add ethanol and be mixed with pure molten thin film coating material solution, stir, for subsequent use;
(2) preheating: the Radix Gentianae element sheet that suppresses is placed seed-coating machine, open hot blast, and rotate main frame, Radix Gentianae element sheet is rolled in seed-coating machine, temperature is raised to 38～42 ℃ gradually;
(3) spray: regulate spray gun, the pure molten thin film coating material solution that stirs evenly is sprayed on the plain sheet in the rolling, pure molten thin film coating material solution at plain sheet moistened surface, sprawl and condense, until color and luster is even, drying namely makes the Radix Gentianae Film coated tablets.
During described preparation Radix Gentianae Film coated tablets, every 100kg Radix Gentianae element sheet 037kg thin film coating material; The amount of solution of used thin film coating material is 7～10kg.
A kind of Radix Gentianae Film coated tablets that the present invention proposes and preparation method thereof, adopt drug effect and original Radix Gentianae coated tablet of the prepared Radix Gentianae Film coated tablets of above-mentioned preparation method basic identical, but the present invention compares with existing coated tablet, have the following advantages: 1. use adjuvant few, reduced cost; 2. it is broken to have reduced tablet, has improved productive rate, has greatly shortened the production time; 3. improved the mode of appearance of tablet; 4. humidity resistance is good, has increased the stability of medicine; 5. increased the dissolution rate of tablet, made the rapid disintegrate of medicine, rapid-action, improve bioavailability and clinical efficacy; 6. cover the bad smell of medicine; Radix Gentianae Film coated tablets of the present invention is applicable to extensive crowd, comprises diabetics.
The preparation technology of Radix Gentianae Film coated tablets of the present invention is simple, and processing ease is easy to grasp, and equipment investment is low, and is with short production cycle, and prepared pharmaceutical properties is stable, guarantees pharmaceutical effectiveness.
The specific embodiment
Embodiment in conjunction with providing is illustrated the present invention:
A kind of Radix Gentianae Film coated tablets, described Radix Gentianae Film coated tablets refer to apply the formed Radix Gentianae tablet of pure molten thin film coating material on the surface of Radix Gentianae element sheet by mist.
The preparation method of preparation Radix Gentianae Film coated tablets, its step is as follows:
(1) with slurry: the thin film coating material of 0.7kg is placed slurry commanding tank, add 95% ethanol 820kg, be mixed with pure molten thin film coating material solution, stir, for subsequent use;
(2) preheating: the Radix Gentianae element sheet 100kg that suppresses is placed seed-coating machine, open hot blast, and rotate main frame, Radix Gentianae element sheet is rolled in seed-coating machine, temperature is raised to 38～42 ℃ gradually;
(3) spray: regulate spray gun, the pure molten thin film coating material solution that stirs evenly is sprayed on the plain sheet in the rolling, pure molten thin film coating material solution at plain sheet moistened surface, sprawl and condense, until color and luster is even, drying namely makes Radix Gentianae Film coated tablets 100.5kg.
During preparation Radix Gentianae Film coated tablets, every 100kg Radix Gentianae element sheet 0.7kg thin film coating material; The amount of solution of used thin film coating material is 7～10kg.
Claims (3)
1. Radix Gentianae Film coated tablets is characterized in that: described Radix Gentianae Film coated tablets refers to apply the formed Radix Gentianae tablet of pure molten thin film coating material on the surface of Radix Gentianae element sheet by mist.
2. prepare the preparation method of the described Radix Gentianae Film coated tablets of claim 1, it is characterized in that: the step of described preparation method is as follows:
(1) with slurry: thin film coating material is placed slurry commanding tank, add ethanol and be mixed with pure molten thin film coating material solution, stir, for subsequent use;
(2) preheating: the Radix Gentianae element sheet that suppresses is placed seed-coating machine, open hot blast, and rotate main frame, Radix Gentianae element sheet is rolled in seed-coating machine, temperature is raised to 38～42 ℃ gradually;
(3) spray: regulate spray gun, the pure molten thin film coating material solution that stirs evenly is sprayed on the plain sheet in the rolling, pure molten thin film coating material solution at plain sheet moistened surface, sprawl and condense, until color and luster is even, drying namely makes the Radix Gentianae Film coated tablets.
3. Radix Gentianae Film coated tablets according to claim 1 is characterized in that: during preparation Radix Gentianae Film coated tablets, and every 100kg Radix Gentianae element sheet 0.7kg thin film coating material; The amount of solution of used thin film coating material is 7～10kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104329837A CN102885871A (en) | 2012-11-04 | 2012-11-04 | Gentiana scabra bage film coated tablet and method for producing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104329837A CN102885871A (en) | 2012-11-04 | 2012-11-04 | Gentiana scabra bage film coated tablet and method for producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102885871A true CN102885871A (en) | 2013-01-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104329837A Pending CN102885871A (en) | 2012-11-04 | 2012-11-04 | Gentiana scabra bage film coated tablet and method for producing same |
Country Status (1)
| Country | Link |
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| CN (1) | CN102885871A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200056365A (en) * | 2020-05-13 | 2020-05-22 | 경희대학교 산학협력단 | Composition for preventing or treating prediabetes or diabetes comrising fractionation of Gentiana scabra extracts |
-
2012
- 2012-11-04 CN CN2012104329837A patent/CN102885871A/en active Pending
Non-Patent Citations (3)
| Title |
|---|
| 《中国野生植物资源》 20030225 陈绚等 苦胆草片薄膜包衣工艺研究 第21卷, 第6期 * |
| 陆彬: "《药剂学实验》", 31 October 1997, 人民卫生出版社 * |
| 陈绚等: "苦胆草片薄膜包衣工艺研究", 《中国野生植物资源》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200056365A (en) * | 2020-05-13 | 2020-05-22 | 경희대학교 산학협력단 | Composition for preventing or treating prediabetes or diabetes comrising fractionation of Gentiana scabra extracts |
| KR102189149B1 (en) | 2020-05-13 | 2020-12-09 | 경희대학교 산학협력단 | Composition for preventing or treating prediabetes or diabetes comrising fractionation of Gentiana scabra extracts |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20130123 |