CN105334327A - 一种用于检测眼病的试剂盒及其检测方法 - Google Patents
一种用于检测眼病的试剂盒及其检测方法 Download PDFInfo
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- CN105334327A CN105334327A CN201510723711.6A CN201510723711A CN105334327A CN 105334327 A CN105334327 A CN 105334327A CN 201510723711 A CN201510723711 A CN 201510723711A CN 105334327 A CN105334327 A CN 105334327A
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- sicam
- aptamer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70525—ICAM molecules, e.g. CD50, CD54, CD102
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/046—Thyroid disorders
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/16—Ophthalmology
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- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
名称 | 解离常数Kd(单位nM) |
sICAM-1-1 | 8.8 |
sICAM-1-2 | 8.9 |
sICAM-1-3 | 9.0 |
sICAM-1-4 | 7.9 |
sICAM-1-5 | 8.3 |
sICAM-1-6 | 8.2 |
sICAM-1-7 | 8.9 |
sICAM-1-8 | 9.3 |
sICAM-1-9 | 8.7 |
sICAM-1-10 | 8.1 |
sICAM-1-11 | 8.0 |
sICAM-1-12 | 9.4 |
sICAM-1-13 | 7.8 |
sICAM-1-14 | 8.6 |
sICAM-1-15 | 8.9 |
PBS空白对照 | 无结合能力 |
Claims (6)
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
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CN201610628554.5A CN106248964A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201510723711.6A CN105334327B (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628510.2A CN105974137A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628596.9A CN105974138A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628671.1A CN106018834A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628675.XA CN106018835A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629097.1A CN105974140A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628827.6A CN106248965A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628826.1A CN106018836A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629215.9A CN106248966A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628672.6A CN105974139A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629366.4A CN106199009A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629367.9A CN106053848A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628761.0A CN106199008A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628509.XA CN106199006A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
Applications Claiming Priority (1)
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CN201510723711.6A CN105334327B (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
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CN201610629215.9A Division CN106248966A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628827.6A Division CN106248965A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628761.0A Division CN106199008A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628675.XA Division CN106018835A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628510.2A Division CN105974137A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628509.XA Division CN106199006A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629367.9A Division CN106053848A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629097.1A Division CN105974140A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628672.6A Division CN105974139A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628671.1A Division CN106018834A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628596.9A Division CN105974138A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629366.4A Division CN106199009A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628554.5A Division CN106248964A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628826.1A Division CN106018836A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
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CN105334327A true CN105334327A (zh) | 2016-02-17 |
CN105334327B CN105334327B (zh) | 2017-03-22 |
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CN201510723711.6A Active CN105334327B (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628510.2A Withdrawn CN105974137A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628761.0A Withdrawn CN106199008A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629215.9A Withdrawn CN106248966A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628675.XA Withdrawn CN106018835A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628596.9A Withdrawn CN105974138A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629366.4A Withdrawn CN106199009A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628509.XA Withdrawn CN106199006A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629367.9A Withdrawn CN106053848A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628826.1A Withdrawn CN106018836A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628672.6A Withdrawn CN105974139A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628671.1A Withdrawn CN106018834A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628554.5A Withdrawn CN106248964A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629097.1A Withdrawn CN105974140A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
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CN201610628510.2A Withdrawn CN105974137A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628761.0A Withdrawn CN106199008A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629215.9A Withdrawn CN106248966A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628675.XA Withdrawn CN106018835A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628596.9A Withdrawn CN105974138A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629366.4A Withdrawn CN106199009A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628509.XA Withdrawn CN106199006A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629367.9A Withdrawn CN106053848A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628826.1A Withdrawn CN106018836A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628672.6A Withdrawn CN105974139A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628671.1A Withdrawn CN106018834A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610628554.5A Withdrawn CN106248964A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
CN201610629097.1A Withdrawn CN105974140A (zh) | 2015-11-01 | 2015-11-01 | 一种用于检测眼病的试剂盒及其检测方法 |
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US11274308B2 (en) * | 2018-07-26 | 2022-03-15 | Bracco Imaging S.P.A. | ICAM-1 aptamers, diagnostic and therapeutic uses thereof |
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2015
- 2015-11-01 CN CN201610628827.6A patent/CN106248965A/zh not_active Withdrawn
- 2015-11-01 CN CN201510723711.6A patent/CN105334327B/zh active Active
- 2015-11-01 CN CN201610628510.2A patent/CN105974137A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628761.0A patent/CN106199008A/zh not_active Withdrawn
- 2015-11-01 CN CN201610629215.9A patent/CN106248966A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628675.XA patent/CN106018835A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628596.9A patent/CN105974138A/zh not_active Withdrawn
- 2015-11-01 CN CN201610629366.4A patent/CN106199009A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628509.XA patent/CN106199006A/zh not_active Withdrawn
- 2015-11-01 CN CN201610629367.9A patent/CN106053848A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628826.1A patent/CN106018836A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628672.6A patent/CN105974139A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628671.1A patent/CN106018834A/zh not_active Withdrawn
- 2015-11-01 CN CN201610628554.5A patent/CN106248964A/zh not_active Withdrawn
- 2015-11-01 CN CN201610629097.1A patent/CN105974140A/zh not_active Withdrawn
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Also Published As
Publication number | Publication date |
---|---|
CN106199009A (zh) | 2016-12-07 |
CN106199006A (zh) | 2016-12-07 |
CN105974138A (zh) | 2016-09-28 |
CN106248964A (zh) | 2016-12-21 |
CN106018836A (zh) | 2016-10-12 |
CN106018834A (zh) | 2016-10-12 |
CN106018835A (zh) | 2016-10-12 |
CN105334327B (zh) | 2017-03-22 |
CN106248965A (zh) | 2016-12-21 |
CN106248966A (zh) | 2016-12-21 |
CN105974139A (zh) | 2016-09-28 |
CN106053848A (zh) | 2016-10-26 |
CN106199008A (zh) | 2016-12-07 |
CN105974140A (zh) | 2016-09-28 |
CN105974137A (zh) | 2016-09-28 |
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