CN105311394A - Swelling-dissipating and stagnation-eliminating preparation for treating mastodynia and preparation method thereof - Google Patents
Swelling-dissipating and stagnation-eliminating preparation for treating mastodynia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a swelling-dissipating and stagnation-eliminating preparation for treating mastodynia. The preparation is mainly prepared from, by mass, 8-14 parts of Chinese dodder seeds, 6-13 parts of all-grass of oberonia iridifolia, 7-12 parts of vitex leaves, 5-9 parts of Chinese mahonia stems, 8-13 parts of ishige okamurae, 6-11 parts of clematis tangutica, 8-16 parts of trichosanthes seeds, 7-13 parts of codonopsis pilosula, 6-12 parts of prinsepia utilis, 3-6 parts of raw oyster shells, 7-11 parts of gold stargrass herbs, 6-10 parts of Chinese fan palm seeds, 9-13 parts of alysicarpus vaginalis and 7-14 parts of Chinese enkianthus. The swelling-dissipating and stagnation-eliminating preparation is good in treatment effect, low in cost, short in treatment course and capable of treating mastodynia both in symptom and in root cause, the composition compatibility is precise, medicinal raw materials can work together for achieving the effects of regulating qi to relieve pain, dispersing blood stasis, eliminating stagnation and the like, and a prepared product is safe, reliable, free of adverse reaction and worthy of being popularized.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of dispersing swelling and dissipating binds preparation and preparation method for the treatment of mastalgia.
Background technology
Mastalgia, also known as pure breast epithelium hypertrophy disease, is the early lesion of mammary dysplasia.The pathological characteristic of this disease is that the diseased region of cyclomastopathy is strong but pliable in texture, and without peplos, unclear with normal structure boundary, tangent plane is canescence fine granularity outward appearance.Visible end latex dust and acinar epithelia hypertrophy under mirror also come off, and latex dust is expanded and distending pain, or causes mammary duct ectasia and form little cyst, or proliferation of fibrous tissue in lobules of mammary gland, merge mutually, or lobule interstitial have lymphocytic infiltration between lobule.Mastalgia main manifestations is distending pain of the breast, lump in breast, and has significantly periodicity and self limiting feature.
Publication No. CN103446500A(application number 201310420009.3) Chinese patent literature disclose a kind of treat cyclomastopathy, mastalgia and puerperal galactostasis Chinese medicine composition, by Cornu Cervi Degelatinatum 9-15 part of weight portion, Ramulus Cinnamomi 9-15 part, Radix Bupleuri 9-15 part, Fructus Trichosanthis 8-12 part, Radix Angelicae Sinensis 8-12 part, Rhizoma Chuanxiong 8-12 part, Fructus Liquidambaris 5-9 part, Concha Ostreae 9-15 part, Flos Albiziae 5-9 part, Fructus Hordei Germinatus 5-9 part forms.Publication No. CN103585258A(application number 201310488731.0) Chinese patent literature disclose a kind of Chinese medicine composition being used for the treatment of mastalgia, comprise Radix Angelicae Sinensis 14-16 gram, Rhizoma Chuanxiong 11-13 gram, Myrrha 8-10 gram, Pericarpium Trichosanthis 11-13 gram, Radix Glycyrrhizae 5-7 gram.Publication No. CN103505599A(application number 201310432033.9) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of mastalgia, said composition comprises Oral preparation and externally dressing; The composition of Oral preparation comprises with parts by weight: Radix Bupleuri 8-12 part, Rhizoma Cyperi 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Radix Angelicae Sinensis 8-15, Radix Paeoniae Alba 9-14, Rhizoma Pinelliae 8-12 part, Rhizoma Chuanxiong 8-12 part, Fructus Toosendan 8-12 part, Radix Glycyrrhizae 3-8 part, or its composition comprises Radix Bupleuri 8-12 part, Radix Rehmanniae Preparata 10-15 part, Radix Angelicae Sinensis 10-15 part, Rhizoma Cyperi 8-13 part, Cornu Cervi Degelatinatum 8-12 part, Thallus Laminariae (Thallus Eckloniae) 8-12 part, Sargassum 7-12 part, Fructus Trichosanthis 8-13 part; The composition of externally dressing with parts by weight is: Radix Aucklandiae 12-17 part, Fructus Amomi 7-13 part, Radix Rehmanniae 25-35 part.
Chinese traditional treatment mastalgia can dialectical treatmert, and side effect is little, but the comparatively significant traditional Chinese medical science formula of therapeutic effect is very few at present, therefore can develop the good traditional Chinese medical science formula of more curative effect to select for patient.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of dispersing swelling and dissipating binds preparation and the preparation method of preparing simple, eutherapeutic treatment mastalgia.
Technical scheme of the present invention is:
The dispersing swelling and dissipating binds preparation for the treatment of mastalgia, is prepared from primarily of following bulk drugs, is mass parts: Semen Cuscutae 8-14, Herba Oberoniae iridifoliae 6-13, Folium Viticis Negundo 7-12, Caulis Mahoniae 5-9, Ishige okamurae Yendo 8-13, Herba Clematidis tanguticae 6-11, trichosanthes seed 8-16, Radix Codonopsis 7-13, Folium Prinsepiae Utilis 6-12, Concha Ostreae 3-6, Herba hypoxis aureae 7-11, Chinese fanpalm seed 6-10, Canis familiaris L. ant grass 9-13, Chinese enkianthus 7-14.
In preferred scheme, Semen Cuscutae 10-12, Herba Oberoniae iridifoliae 8-11, Folium Viticis Negundo 8-11, Caulis Mahoniae 6-8, Ishige okamurae Yendo 9-12, Herba Clematidis tanguticae 7-10, trichosanthes seed 10-14, Radix Codonopsis 9-11, Folium Prinsepiae Utilis 8-10, Concha Ostreae 4-5, Herba hypoxis aureae 8-10, Chinese fanpalm seed 7-9, Canis familiaris L. ant grass 10-12, Chinese enkianthus 9-12.
Be more preferably, Semen Cuscutae 11, Herba Oberoniae iridifoliae 9.5, Folium Viticis Negundo 9.5, Caulis Mahoniae 7, Ishige okamurae Yendo 10.5, Herba Clematidis tanguticae 8.5, trichosanthes seed 12, Radix Codonopsis 10, Folium Prinsepiae Utilis 9, Concha Ostreae 4.5, Herba hypoxis aureae 8, Chinese fanpalm seed 8, Canis familiaris L. ant grass 11, Chinese enkianthus 10.5.
The preparation method of the powder of the dispersing swelling and dissipating binds preparation of described treatment mastalgia, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, decocting in water is added together with step (2) (3) made crude drug with Semen livistonae chinensis sub-pieces made in step (1), amount of water is 6 times of boiled crude drug quality, and big fire is boiled rear little fire and continued to boil 30 minutes, filters, collect medicinal liquid, filtering residue adds water and boils, and decocting time, with first time, merges twice and decocts gained medicinal liquid;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, join in step (4) made medicinal liquid after making medicated powder, heating is condensed into clear paste, and dry, pulverize sieves makes powder, sterilizing, obtains powder.
The preparation method of the dispersing swelling and dissipating binds preparation powder of described treatment mastalgia, step (5) pulverized 300-400 mesh sieve (preferred, to pulverize 350 mesh sieves).
The preparation method of the pill of the dispersing swelling and dissipating binds preparation of described treatment mastalgia, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, add decocting in water with Semen livistonae chinensis sub-pieces made in step (1) together with step (2) (3) made crude drug, amount of water is 6 times of boiled crude drug quality, big fire is boiled rear little fire and is continued to boil, filter, collect medicinal liquid, filtering residue adds water and boils, decocting time is with first time, merge twice and decoct gained medicinal liquid, dry after concentrated, make medicated powder;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, make medicated powder and the made medicated powder stirring and evenly mixing of step (4), with mature vinegar with refined honey is general makes ball, dry, obtain pill.
The preparation method of the dispersing swelling and dissipating binds preparation pill of described treatment mastalgia, step (4) big fire is boiled rear little fire and is continued to boil 24-36 minute (preferred, little fire continues to boil 28-32 minute; Be more preferably, little fire continues to boil 30 minutes).
The preparation method of the tablet of the dispersing swelling and dissipating binds preparation of described treatment mastalgia, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Semen Cuscutae, Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Concha Ostreae, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, decocting in water is added together with step (1) (2) (3) made crude drug, decoct three times, each big fire is boiled rear little fire and is continued to boil 20-30 minute (preferred, little fire continues to boil 22-28 minute; Be more preferably, little fire continues to boil 25 minutes), filter, collect medicinal liquid, merge three times and decoct gained medicinal liquid, dry after concentrated, make medicated powder;
(5) step (4) made medicated powder is pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet, sterilizing, subpackage, obtains tablet.
The preparation method of the dispersing swelling and dissipating binds formulation tablet of described treatment mastalgia, it is the 6-8 of total raw material medicine quality doubly (preferred, at every turn to decoct 7 times that amount of water is total raw material medicine quality) that step (4) decocts amount of water at every turn.
The preparation method of the decoction of the dispersing swelling and dissipating binds preparation of described treatment mastalgia, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) Concha Ostreae is placed in non iron container, the big fire that adds water is boiled (amount of water is 6 times of total raw material medicine quality), add the clean Semen Cuscutae of roguing, Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus and step (1) (2) (3) made crude drug again, big fire is boiled rear little fire and is continued to boil 24-36 minute (preferred, little fire continues to boil 28-32 minute; Be more preferably, little fire continues to boil 30 minutes), filter, collect medicinal liquid, filtering residue adds water and boils, and decocting time is with first time, and merge twice gained medicinal liquid, sterilizing, obtains decoction.
The preparation method of the dispersing swelling and dissipating binds preparation decoction of described treatment mastalgia, step (4) big fire that adds water is boiled 27-45 minute (preferred, 30-42 minute is boiled in the big fire that adds water; Be more preferably, the big fire that adds water boils 36 minutes).
The dispersing swelling and dissipating binds preparation for the treatment of mastalgia provided by the invention is through clinical practice for many years in conjunction with the development of Chinese medicine principle, and the simple science of preparation method, products made thereby is taken easy to carry.In addition, excellent results of the present invention also shows:
1, good effect of the present invention, cost is low, short treating period, can treating both the principal and secondary aspects of a disease mastalgia;
2, the rigorous compatibility of this prescription, crude drug can be worked in coordination with and be played the effect such as regulating QI to relieve pain, blood stasis-eliminating and stagnation-dissipating;
3, products made thereby of the present invention is safe and reliable, has no adverse reaction, and is worthy to be popularized.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the dispersing swelling and dissipating binds preparation for the treatment of mastalgia, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cuscutae 8 parts, Herba Oberoniae iridifoliae 6 parts, Folium Viticis Negundo 7 parts, Caulis Mahoniae 5 parts, Ishige okamurae Yendo 8 parts, Herba Clematidis tanguticae 6 parts, trichosanthes seed 8 parts, Radix Codonopsis 7 parts, Folium Prinsepiae Utilis 6 parts, Concha Ostreae 3 parts, Herba hypoxis aureae 7 parts, Chinese fanpalm seed 6 parts, Canis familiaris L. ant grass 9 parts, Chinese enkianthus 7 parts.
The preparation method of the dispersing swelling and dissipating binds preparation powder of above-mentioned treatment mastalgia is:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 25 minutes, take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, decocting in water is added together with step (2) (3) made crude drug with Semen livistonae chinensis sub-pieces made in step (1), amount of water is 6 times of boiled crude drug quality, and big fire is boiled rear little fire and continued to boil 30 minutes, filters, collect medicinal liquid, filtering residue adds water and boils, and decocting time, with first time, merges twice and decocts gained medicinal liquid;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, join in step (4) made medicinal liquid after making medicated powder, heating is condensed into clear paste, dry, pulverize 350 mesh sieves and makes powder, sterilizing, and obtained powder.
embodiment 2the dispersing swelling and dissipating binds preparation for the treatment of mastalgia, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cuscutae 14 parts, Herba Oberoniae iridifoliae 13 parts, Folium Viticis Negundo 12 parts, Caulis Mahoniae 9 parts, Ishige okamurae Yendo 13 parts, Herba Clematidis tanguticae 11 parts, trichosanthes seed 16 parts, Radix Codonopsis 13 parts, Folium Prinsepiae Utilis 12 parts, Concha Ostreae 6 parts, Herba hypoxis aureae 11 parts, Chinese fanpalm seed 10 parts, Canis familiaris L. ant grass 13 parts, Chinese enkianthus 14 parts.
The preparation method of the dispersing swelling and dissipating binds preparation pill for the treatment of mastalgia is:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 25 minutes, take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, add decocting in water with Semen livistonae chinensis sub-pieces made in step (1) together with step (2) (3) made crude drug, amount of water is 6 times of boiled crude drug quality, big fire is boiled rear little fire and is continued to boil 30 minutes, filter, collect medicinal liquid, filtering residue adds water and boils, decocting time is with first time, merge twice and decoct gained medicinal liquid, dry after concentrated, make medicated powder;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, make medicated powder and the made medicated powder stirring and evenly mixing of step (4), with mature vinegar with refined honey is general makes ball, dry, obtain pill.
Model case: xxx, female, 36 years old.Main suit: bilateral lump in breast pain recurrent exerbation 5 years, change relevant with menstruation, premenstrual symptom is obvious, through after alleviation, menstruation and two is just all normal, once took the pain relief of RUPIXIAO capsule, nearly one week, emotion was not smooth, susceptible to lose temper due to restlessness, mastalgia unbearably, can not be touched, poor appetite, examination in hospital, the outside upper quadrant of left breast is had an appointment 2.0 × 2.0cm lump, and right newborn LOQ is had an appointment 1.2 × 1.8cm lump, medium hardness, mobility is good, ultrasonic display bilateral breast hypertrophy echo increases thick, and bilateral axillary regions submental lymph nodes, without great, is diagnosed as mastalgia.
Take the dispersing swelling and dissipating binds preparation pill of the present embodiment gained treatment mastalgia, every day 2 times, each 2-3 grain, warm water delivery service, 30 days courses for the treatment of.After taking 4 days, pain relief, after taking a course for the treatment of, pain disappears substantially, mass reduction, after taking two courses for the treatment of, breast is without pain, and lump is eliminated substantially, and after taking three courses for the treatment of, lump is complete, disappear, through fore udder not pain again, patient fully recovers, and follows up a case by regular visits to without recurrence after 2 years.
embodiment 3the dispersing swelling and dissipating binds preparation for the treatment of mastalgia, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cuscutae 10 parts, Herba Oberoniae iridifoliae 8 parts, Folium Viticis Negundo 8 parts, Caulis Mahoniae 6 parts, Ishige okamurae Yendo 9 parts, Herba Clematidis tanguticae 7 parts, trichosanthes seed 10 parts, Radix Codonopsis 9 parts, Folium Prinsepiae Utilis 8 parts, Concha Ostreae 4 parts, Herba hypoxis aureae 8 parts, Chinese fanpalm seed 7 parts, Canis familiaris L. ant grass 10 parts, Chinese enkianthus 9 parts.
The preparation method of the dispersing swelling and dissipating binds formulation tablet for the treatment of mastalgia is:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 25 minutes, take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Semen Cuscutae, Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Concha Ostreae, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, add decocting in water together with step (1) (2) (3) made crude drug, decoct three times, each decoction amount of water is 7 times of total raw material medicine quality, each big fire is boiled rear little fire and is continued to boil 25 minutes, filter, collect medicinal liquid, merge three times and decoct gained medicinal liquid, dry after concentrated, make medicated powder;
(5) step (4) made medicated powder is pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet, sterilizing, subpackage, obtains tablet.
Model case: xxx, female, 40 years old.Main suit: premenstrual right breast nipple distending pain, have lump 2 years, slightly alleviate through after date pain, breast surface skin is without redness, nearly two weeks, there is distending pain of the breast before menstruation, and be radiated to oxter, both arms are stretched and are lifted inconvenience, and nipple has a small amount of discharge, and leucorrhea amount is how rare clearly, extremity are not warm, examination in hospital, light red tongue, tongue is white, and deep-thready pulse, through ultrasonic examination, right breast LOQ has the lump of 1.5 × 2.0cm size, and right side axillary lymph node has slight enlargement, is diagnosed as mastalgia.
Take the dispersing swelling and dissipating binds formulation tablet of the present embodiment gained treatment mastalgia, adopt every day 2 times, each 4, with warm water delivery service, 30 days courses for the treatment of.After taking one week, pain obviously alleviates, and leucorrhea reduces, and extremity turn temperature, and after taking a course for the treatment of, pain disappears, and lump obviously reduces, and after taking two courses for the treatment of, all non-distending pain of breast before and after menstruation, extremity are warm, and patient fully recovers, and follows up a case by regular visits to and do not recur after 1 year.
embodiment 4the dispersing swelling and dissipating binds preparation for the treatment of mastalgia, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cuscutae 12 parts, Herba Oberoniae iridifoliae 11 parts, Folium Viticis Negundo 11 parts, Caulis Mahoniae 8 parts, Ishige okamurae Yendo 12 parts, Herba Clematidis tanguticae 10 parts, trichosanthes seed 14 parts, Radix Codonopsis 11 parts, Folium Prinsepiae Utilis 10 parts, Concha Ostreae 5 parts, Herba hypoxis aureae 10 parts, Chinese fanpalm seed 9 parts, Canis familiaris L. ant grass 12 parts, Chinese enkianthus 12 parts.
The preparation method of the dispersing swelling and dissipating binds preparation decoction for the treatment of mastalgia is:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 25 minutes, take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) Concha Ostreae is placed in non iron container, the big fire that adds water is boiled 36 minutes (amount of water is 6 times of total raw material medicine quality), add the clean Semen Cuscutae of roguing, Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus and step (1) (2) (3) made crude drug again, big fire is boiled rear little fire and is continued to boil 30 minutes, filters, collect medicinal liquid, filtering residue adds water and boils, and decocting time, with first time, merges twice gained medicinal liquid, sterilizing, obtains decoction.
Model case: xxx, female, 24 years old.Main suit: nearly half a year, two breast has a dull ache, whenever menstrual period pain obvious, through after automatically alleviate, nearly 3 days, bimastism pain was obvious, is radiated to side of body rib, is difficult to touch, take tablet for alleviating pain, Tongjing tablet, symptom is improved not obvious, with lower abdominal pain, the soreness of waist, poor appetite, examination in hospital, tongue is dark red, tongue is white, thready and hesitant pulse, and the outer lower limit of two breast can touch lump, matter is tough, and color ultrasound display cyclomastopathy, is diagnosed as mastalgia.
Take the dispersing swelling and dissipating binds preparation decoction of the present embodiment gained treatment mastalgia, adopt every day 2 times, each 300-350ml, warm, 30 days courses for the treatment of.After taking 4 days, breast and lower abdomen pain relief, after taking two weeks, pain disappears, after taking a course for the treatment of, in breast, lump obviously reduces, and after taking two courses for the treatment of, breast and lower abdomen pain disappear, menstrual period also have no pain, and in breast, lump disappears completely, and patient fully recovers, and follow up a case by regular visits to without recurrence after 1 year.
embodiment 5the dispersing swelling and dissipating binds preparation for the treatment of mastalgia, is prepared from (every part of 10g) primarily of following bulk drugs: Semen Cuscutae 11 parts, Herba Oberoniae iridifoliae 9.5 parts, Folium Viticis Negundo 9.5 parts, Caulis Mahoniae 7 parts, Ishige okamurae Yendo 10.5 parts, Herba Clematidis tanguticae 8.5 parts, trichosanthes seed 12 parts, Radix Codonopsis 10 parts, Folium Prinsepiae Utilis 9 parts, Concha Ostreae 4.5 parts, Herba hypoxis aureae 8 parts, Chinese fanpalm seed 8 parts, Canis familiaris L. ant grass 11 parts, Chinese enkianthus 10.5 parts.
The preparation method of the dispersing swelling and dissipating binds preparation powder for the treatment of mastalgia is:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 25 minutes, take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, decocting in water is added together with step (2) (3) made crude drug with Semen livistonae chinensis sub-pieces made in step (1), amount of water is 6 times of boiled crude drug quality, and big fire is boiled rear little fire and continued to boil 30 minutes, filters, collect medicinal liquid, filtering residue adds water and boils, and decocting time, with first time, merges twice and decocts gained medicinal liquid;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, join in step (4) made medicinal liquid after making medicated powder, heating is condensed into clear paste, dry, pulverize 350 mesh sieves and makes powder, sterilizing, and obtained powder.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Semen Cuscutae: base is former: be the seed of convolvulus cuscuta plant or cuscuta japonica Choisy.Nature and flavor with return through: pungent, sweet, flat.Return liver,kidney,spleen warp.There is liver and kidney tonifying, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, effect of antidiarrheal.External pathogenic wind expelling speckle dispelling.For deficiency of the liver and kindey, soreness of the waist and knees, impotence and seminal emission, enuresis frequent micturition.Vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, blurred vision tinnitus, spleen is suffered from a deficiency of the kidney and is rushed down, externally treating leucoderma.
Herba Oberoniae iridifoliae: base is former: be the herb of orchid Rhizoma Iridis Tectori orchid.Nature and flavor: light are cool.Function cures mainly: regulate the flow of vital energy and help digestion, clearing away heat and promoting diuresis, cough-relieving pain relieving.For dyspepsia, stomachache, enteritis, urinary tract infection, cough, bronchitis, asthma, traumatic injury, fracture, venom.
Folium Viticis Negundo: base is former: be the blade of Verbenaceae Herba Viticis Cannabifoliae.Nature and flavor: micro-hardship, pungent are flat.Gui Jing: return lung meridian.Function cures mainly: eliminate the phlegm, and cough-relieving is relievingd asthma.For cough with asthma, chronic bronchitis.
Caulis Mahoniae: base is former: be the stem of Berberidaceae plant Mahonia bealei (Fort.) Carr., mahonia fortuneiFedde or south China Mahonia fortunei (Lindl.) Fedde.Nature and flavor: bitter are flat.Function cures mainly: lung heat clearing, and only consumptive disease is coughed, parasite killing, logical stool.
Ishige okamurae Yendo: base is former: be the frond of Ishigeaceae plant Ishige okamurae Yendo and lobate Ishige okamurae Yendo.Nature and flavor: salty, cold.Gui Jing: Liver Channel.Function cures mainly: hard masses softening and resolving, and removing toxic substances, drives ascarid.Main lymphonodi cervicales swells, goiter, laryngitis, ascariasis.
Herba Clematidis tanguticae: base is former: be Herb or the stem and leaf of ranunculaceae plant Herba Clematidis tanguticae.Nature and flavor: sweet are bitter, flat.Gui Jing: spleen, stomach warp.Function cures mainly: stomach invigorating removing food stagnancy, removing toxic substances removing dampness.Main accumulation of food in the stomach and intes tine due to indigestion, abdominal distention painful abdominal mass plug, abdomen gushes diarrhoea, carbuncle skin ulcer, eczema.
Trichosanthes seed: base is former: be the seed of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms, large sub-Fructus Trichosanthis etc.Nature and flavor: sweet, cold.Gui Jing: enter lung, stomach, large intestine channel.Function cures mainly: lung moistening, reduces phlegm, laxation.Control phlegm-heat cough, dryness accumulated in the stomach and intestine constipation, carbuncle, breast is few.
Radix Codonopsis: base is former: be the root of Campanulaceae Radix Codonopsis.Nature and flavor with return through: sweet, flat.Return spleen, lung meridian.Function with cure mainly: spleen invigorating lung benefiting, nourishing blood to promote the production of body fluid.For deficiency of both the splenic and pulmonary QI, lack of appetite asthenia, cough dyspnea due to deficiency, insufficiency of vital energy and blood, shallow complexion, shortness of breath and palpitation, Tianjin wound is thirsty, and interior-heat is quenched one's thirst.
Folium Prinsepiae Utilis: base is former: be the leaf of rosaceous plant Folium Prinsepiae Utilis.Nature and flavor: cold nature, bitter in the mouth.Function cures mainly: counteracting toxic substances, blood stasis dispelling.Control skin sore, fracture.
Concha Ostreae: base is former: be the shell of Ostreidae animal Crassostrea rivularis, long Concha Ostreae or Dalian Bay Concha Ostreae etc.Concha Ostreae: clean, dry, pulverize use.Nature and flavor: salty, are slightly cold.Gui Jing: return liver, gallbladder, kidney channel.Function cures mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule, lump in the abdomen mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.
Herba hypoxis aureae: base is former: be the Herb of amrallid Herba hypoxis aureae.Nature and flavor: sweet, micro-pungent, warm.Function cures mainly: warming the kidney to invigorate YANG, regulating QI to relieve pain.Main lumbago due to renal deficiency, sexual impotence, insomnia, colic of cold type is suffered from abdominal pain.
Chinese fanpalm seed: base is former: be the seed of babassu Semen livistonae chinensis.Nature and flavor: sweet in the mouth, bitter, property is put down, mild toxicity.Function cures mainly: blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.Main chronic hepatitis, lump in the abdomen.
Canis familiaris L. ant grass: base is former: be the herb of pulse family Canis familiaris L. ant grass.Nature and flavor: sweet, bitter are flat.Function cures mainly: promoting blood circulation to remove obstruction in the collateral, clearing away heat and eliminating dampness, refutes atrophic debility of bones and swells, removing the necrotic tissue and promoting granulation.
Chinese enkianthus: base is former: be tuber and the root of ericad Chinese enkianthus.Nature and flavor: bitter, cool in nature.Function cures mainly: promoting blood circulation and stopping pain, clearing away heat-damp and promoting diuresis.Main traumatic injury, rheumatic arthralgia, stomachache, hepatitis, edema, innominate toxic swelling.
test example 1the clinical practice of the dispersing swelling and dissipating binds preparation (embodiment 5) of gained treatment mastalgia of the present invention:
In October ,-2014 in July, 2013, filtering out 289 routine mastalgia patients at 4 hospital's Breast Clinics, is women entirely, age 23-47 year, year mean age (36.4 ± 6.8), the course of disease 3 months-8 years, average course of disease (3.2 ± 2.7) year, one-sided breast 174 example, bilateral breast 115 example.Diagnostic criteria: 1. breast has distending pain in various degree, twinge, dull pain or with radiating pain, can be radiated to oxter, shoulder back, with menstrual cycle and emotion changes, premenstrual heavier, through after alleviate; 2. can lay one's hand in the breast of one or both sides and single or several hyperplastic nodule differed in size, in flakes block or intersperse among whole breast, obscure boundary, mobility is good, and matter is tough, and some patients nipple has discharge or pruritus; 3. mammary gland Simple hyperplasia disease is diagnosed as through the imaging of breast molybdenum target or color ultrasound examination.
Patient is divided into two groups at random, experimental group 165 example and matched group 124 routine, two groups in age, the course of disease, the state of an illness etc. without significant difference (
p> 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, and every day takes twice, and each 3-5g(adjusts to some extent depending on concrete condition), 30 days courses for the treatment of, treat two courses for the treatment of, matched group takes other medicine as conventional medication such as RUZENGNING PIAN, RUHE SANJIE PIAN, XIAOHE PIAN.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect situation criterion: cure: mastalgia and tuberosity disappear completely, without recurrence in drug withdrawal 3 months; Effective: mastalgia disappears substantially, tuberosity maximum gauge reduce 50% and more than; Effective: mastalgia alleviates, tuberosity maximum gauge reduces 30% and above but less than 50%, invalid: clinical symptoms and sign are without improvement, and tuberosity does not reduce or increases hardening on the contrary.Result is as shown in table 1.Total effective rate=(curing example+effective example+effectively example)/total number of cases × 100%
Table 1 liang group patient treatment outcome
As shown in Table 1: in experimental group, cure 98 examples (59.4%), effective 50 examples (30.3%), effective 13 examples (7.9%), experimental group total effective rate is 97.6%.In matched group, cure 39 examples (31.5%), effective 49 examples (39.5%), effective 15 examples (12.1%), matched group total effective rate is 83.1%, treatment of control group successful lower than experimental group, two group differences significantly (
p< 0.05).In therapeutic process, the appearance that two groups of patients all have no adverse reaction.
The present invention selects there is Semen Cuscutae liver and kidney tonifying, Herba Oberoniae iridifoliae clearing away heat and promoting diuresis, Folium Viticis Negundo eliminating phlegm and relieving asthma, Caulis Mahoniae lung heat clearing, Ishige okamurae Yendo hard masses softening and resolving, Herba Clematidis tanguticae removing toxic substances removing dampness, trichosanthes seed moistening the lung and resolving phlegm, Radix Codonopsis nourishing blood to promote the production of body fluid, Folium Prinsepiae Utilis counteracting toxic substances blood stasis dispelling, the nourishing YIN of Concha Ostreae YANG hyperactivity suppressing, Herba hypoxis aureae regulating QI to relieve pain, Chinese fanpalm seed blood circulation promoting and blood stasis dispelling, Canis familiaris L. ant grass promoting blood circulation to remove obstruction in the collateral, Chinese enkianthus promoting blood circulation and stopping pain, all medicines share, and can play the effect such as regulating QI to relieve pain, blood stasis-eliminating and stagnation-dissipating.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the dispersing swelling and dissipating binds preparation of mastalgia, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Semen Cuscutae 8-14, Herba Oberoniae iridifoliae 6-13, Folium Viticis Negundo 7-12, Caulis Mahoniae 5-9, Ishige okamurae Yendo 8-13, Herba Clematidis tanguticae 6-11, trichosanthes seed 8-16, Radix Codonopsis 7-13, Folium Prinsepiae Utilis 6-12, Concha Ostreae 3-6, Herba hypoxis aureae 7-11, Chinese fanpalm seed 6-10, Canis familiaris L. ant grass 9-13, Chinese enkianthus 7-14.
2. the dispersing swelling and dissipating binds preparation for the treatment of mastalgia as claimed in claim 1, it is characterized in that, Semen Cuscutae 10-12, Herba Oberoniae iridifoliae 8-11, Folium Viticis Negundo 8-11, Caulis Mahoniae 6-8, Ishige okamurae Yendo 9-12, Herba Clematidis tanguticae 7-10, trichosanthes seed 10-14, Radix Codonopsis 9-11, Folium Prinsepiae Utilis 8-10, Concha Ostreae 4-5, Herba hypoxis aureae 8-10, Chinese fanpalm seed 7-9, Canis familiaris L. ant grass 10-12, Chinese enkianthus 9-12 is (preferred, Semen Cuscutae 11, Herba Oberoniae iridifoliae 9.5, Folium Viticis Negundo 9.5, Caulis Mahoniae 7, Ishige okamurae Yendo 10.5, Herba Clematidis tanguticae 8.5, trichosanthes seed 12, Radix Codonopsis 10, Folium Prinsepiae Utilis 9, Concha Ostreae 4.5, Herba hypoxis aureae 8, Chinese fanpalm seed 8, Canis familiaris L. ant grass 11, Chinese enkianthus 10.5).
3. the preparation method of the powder of the dispersing swelling and dissipating binds preparation of the treatment mastalgia as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, decocting in water is added together with step (2) (3) made crude drug with Semen livistonae chinensis sub-pieces made in step (1), amount of water is 6 times of boiled crude drug quality, and big fire is boiled rear little fire and continued to boil 30 minutes, filters, collect medicinal liquid, filtering residue adds water and boils, and decocting time, with first time, merges twice and decocts gained medicinal liquid;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, join in step (4) made medicinal liquid after making medicated powder, heating is condensed into clear paste, and dry, pulverize sieves makes powder, sterilizing, obtains powder.
4. the preparation method of the dispersing swelling and dissipating binds preparation powder for the treatment of mastalgia as claimed in claim 3, is characterized in that, step (5) pulverized 300-400 mesh sieve (preferred, to pulverize 350 mesh sieves).
5. the preparation method of the pill of the dispersing swelling and dissipating binds preparation of the treatment mastalgia as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, add decocting in water with Semen livistonae chinensis sub-pieces made in step (1) together with step (2) (3) made crude drug, amount of water is 6 times of boiled crude drug quality, big fire is boiled rear little fire and is continued to boil, filter, collect medicinal liquid, filtering residue adds water and boils, decocting time is with first time, merge twice and decoct gained medicinal liquid, dry after concentrated, make medicated powder;
(5) Semen Cuscutae, Concha Ostreae are ground into powder together with step (1) made trichosanthes seed, make medicated powder and the made medicated powder stirring and evenly mixing of step (4), with mature vinegar with refined honey is general makes ball, dry, obtain pill.
6. the preparation method of the dispersing swelling and dissipating binds preparation pill for the treatment of mastalgia as claimed in claim 5, is characterized in that, step (4) big fire is boiled rear little fire and continued to boil 24-36 minute (preferred, little fire continues to boil 28-32 minute; Be more preferably, little fire continues to boil 30 minutes).
7. the preparation method of the tablet of the dispersing swelling and dissipating binds preparation of the treatment mastalgia as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) by Semen Cuscutae, Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Concha Ostreae, Canis familiaris L. ant grass and Chinese enkianthus roguing, clean, decocting in water is added together with step (1) (2) (3) made crude drug, decoct three times, each big fire is boiled rear little fire and is continued to boil 20-30 minute (preferred, little fire continues to boil 22-28 minute; Be more preferably, little fire continues to boil 25 minutes), filter, collect medicinal liquid, merge three times and decoct gained medicinal liquid, dry after concentrated, make medicated powder;
(5) step (4) made medicated powder is pressed into circular or other forms of tablet dosage form according to the preparation for processing of tablet, sterilizing, subpackage, obtains tablet.
8. the preparation method of the dispersing swelling and dissipating binds formulation tablet for the treatment of mastalgia as claimed in claim 7, is characterized in that, each amount of water that decocts of step (4) is the 6-8 of total raw material medicine quality doubly (preferred, each decoction amount of water is 7 times of total raw material medicine quality).
9. the preparation method of the decoction of the dispersing swelling and dissipating binds preparation of the treatment mastalgia as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Chinese fanpalm seed warm water and infiltrate 20 minutes, take out, clean section, add Oleum Ricini and be placed in heating in frying pan, be sprinkled into Semen livistonae chinensis sub-pieces and trichosanthes seed heating stir-fries, fry and heave to trichosanthes seed epidermis, take out, dry in the air cool;
(2) Ishige okamurae Yendo rice-washed water is flooded 2 hours, take out, clean, shredding, be together placed in frying pan heat with wheat bran and stir-fry, fry to the micro-Huang in crude drug surface, take out, sieve and remove wheat bran, dry;
(3) get Folium Viticis Negundo, Folium Prinsepiae Utilis and Herba hypoxis aureae roguing, drench and mix thoroughly into Sucus Zingberis, leave standstill 20-30 minute (preferred, leave standstill 25 minutes), take out, then be placed in the vinegar 5 minutes of boiling, pull out, dry at 50 DEG C;
(4) Concha Ostreae is placed in non iron container, the big fire that adds water is boiled (amount of water is 6 times of total raw material medicine quality), add the clean Semen Cuscutae of roguing, Herba Oberoniae iridifoliae, Caulis Mahoniae, Herba Clematidis tanguticae, Radix Codonopsis, Canis familiaris L. ant grass and Chinese enkianthus and step (1) (2) (3) made crude drug again, big fire is boiled rear little fire and is continued to boil 24-36 minute (preferred, little fire continues to boil 28-32 minute; Be more preferably, little fire continues to boil 30 minutes), filter, collect medicinal liquid, filtering residue adds water and boils, and decocting time is with first time, and merge twice gained medicinal liquid, sterilizing, obtains decoction.
10. the preparation method of the dispersing swelling and dissipating binds preparation decoction for the treatment of mastalgia as claimed in claim 9, is characterized in that, step (4) big fire that adds water is boiled 27-45 minute (preferred, 30-42 minute is boiled in the big fire that adds water; Be more preferably, the big fire that adds water boils 36 minutes).
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| CN104623559A (en) * | 2015-03-09 | 2015-05-20 | 王艳君 | Agent with effects of invigorating blood circulation and removing stasis for eliminating breast lump |
| CN104623451A (en) * | 2015-03-16 | 2015-05-20 | 徐若曾 | Traditional Chinese medicine composition for treating breast cancer |
| CN104623385A (en) * | 2015-03-09 | 2015-05-20 | 王艳君 | Pharmaceutical compound for treating mammary gland hyperplasia and preparation method of pharmaceutical compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104623559A (en) * | 2015-03-09 | 2015-05-20 | 王艳君 | Agent with effects of invigorating blood circulation and removing stasis for eliminating breast lump |
| CN104623385A (en) * | 2015-03-09 | 2015-05-20 | 王艳君 | Pharmaceutical compound for treating mammary gland hyperplasia and preparation method of pharmaceutical compound |
| CN104623451A (en) * | 2015-03-16 | 2015-05-20 | 徐若曾 | Traditional Chinese medicine composition for treating breast cancer |
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