CN105310734B - Barbed suture coated with metal - Google Patents
Barbed suture coated with metal Download PDFInfo
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- CN105310734B CN105310734B CN201510047634.7A CN201510047634A CN105310734B CN 105310734 B CN105310734 B CN 105310734B CN 201510047634 A CN201510047634 A CN 201510047634A CN 105310734 B CN105310734 B CN 105310734B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00792—Plastic surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00893—Material properties pharmaceutically effective
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00969—Surgical instruments, devices or methods, e.g. tourniquets used for transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
- A61B2017/06176—Sutures with protrusions, e.g. barbs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Materials Engineering (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides the barbed suture coated with metal, and the above-mentioned barbed suture coated with metal includes:Barbed suture, the one or both sides of monofilament thread are formed at the thorn shape relative to the length direction of monofilament thread obliquely partial cut;And metal coat film, by being formed in the surface of above-mentioned barbed suture evaporation or fixing metal ions or metallic.Thus promote the mechanical properties for the suture being pierced into inside skin, maintain the continuation of resulting suture, the wrinkle for being formed at skin surface can be removed, and prevent skin surface from sinking.
Description
Technical field
The present invention relates to the barbed suture coated with metal, relates to the use of metal in more detail to apply biological degradability band
The surface of prickseam line, and inhibiting substances is contained in the inside of barbed suture, so as to ensure to be pierced into bio-tissue
The support force of barbed suture, generates collagen, and increases skin elasticity, on the other hand, can minimally suppress for
Skin is pierced into the barbed suture coated with metal of the side effect in affected part.
Background technology
It is well known that skin aging is tied because of the variation of cell, active oxygen radical, the accumulation of toxicant and skin gap
Structure protein deformation etc. and occurs, although to its it is accurate the reason for carried out many researchs, cannot also prove amply all the time respectively
A main cause forms wrinkle in skin by which kind of mechanism, and is used as ageing results, forms wrinkle of skin, reduces elasticity, and
Form spot etc..
Also, since the generative capacity of the collagen closely related with the skin of health reduces, these collagens are fine
The phenomenon increase tangled extremely is tieed up, skin elasticity substantially reduces, and is responsible for the hyaluronic acid of skin moisture-keeping and as one of protein
The growing amount of glutinous polysaccharide substantially reduce.
Up to the present, many materials have been used in order to suppress skin aging, and it is well known that as being used for a long time
Raw material be used as vitamin C (Vitamin C), the superoxide dismutase bragged about in a manner of the smoothing wrinkle based on antioxidant effect
(SOD, Superoxide Dismutase), alpha-tocopherol (Vitamin E), bata-carotene etc. are alleviated by its antioxidant effect
Skin aging, so as to improve wrinkle, and promotes skin elasticity.
Recently, as Chinese herbal medicine cosmetic is popular, many natural materials get most of the attention, and it is well known that passing through this so far
Kind of method, with skin regeneration and wrinkle improvement effect relatively, cannot play satisfied achievement in a short time.
On the other hand, in the past, the mode sunk as wrinkle shaping or solution skin, can enumerate wrinkle and draw skin art, above-mentioned
Wrinkle draws Pi Shuzhong, the muscle film layer of loose skin and the skin of excision relaxation is together pulled, so as to be effectively improved
Deep wrinkle and skin elasticity, but due to being cut, thus postoperative recovery time length, cause to act as the burden to operation
Factor.
Suture operation is as using pin and the biodegradable thread being connected with pin, to be suitable for corium or subcutaneously
The wrinkle of the soft tissues such as fat improves, one kind of the acupuncture and moxibustion treatment of contour correction, as non-operative treatment, is mainly used for face and carries
Rise or eight word wrinkles correct.
The material of thread mainly using polydioxanone (PDO), glycolide-caprolactone copolymer (PGCL,
Glycolide-caprolactone copolymer), polyglycolic acid (PGA, polyglycolic acid), glycolide-the third hand over
A kind of material in ester copolymer (PGLA, Glycolide-lactide copolymer), or use two in above-mentioned substance
The mixture of the kind above, and used with monofilament or multifilament shape, in general, barbed suture is made by carrying out post-processing to monofilament
It is standby.
Metal coat there are into the physical methods such as vacuum vapour deposition, sputtering method and plating, chemistry in the method for macromolecule surface
Plating, reduction method etc. use the chemical method of aqueous solution.
The barbed suture being pierced into organism is dissolved to be absorbed gradually by body fluid, in general, in some months to most 1 years
Interior decomposition and eliminate, but more decompose, the effect as suture more reduces, and therefore, it is necessary to improve the continuation of suture effect.
Meanwhile using existing barbed suture come perform lifting operation in the case of, be not only difficult to suppress by corresponding skin
Side effect caused by affected part is pierced into, also has to suppress side effect and needs to perform additional emergency disposal after lifting operation
Inconvenience.
This side effect be possible to be accordingly pierced into edema, bleeding, pain, extravasated blood trace, inflammation etc. that affected part occurs because
Element.
That is, for existing barbed suture, without should surgical procedure initial stage to being possible to be suffered from by corresponding be pierced into
The technical factor that side effect caused by place takes measures, it is therefore desirable to take measures after the procedure, i.e. belong at rear prescription
Put, so that the incidence of side effect becomes higher, thus, the healing speed in corresponding affected part can only be slack-off.
On the other hand, as with the relevant technology of this suture, disclose Korean Patent Laid-Open 10-2011-0003532
Number, South Korea log in special permission the 10-1132841st, Korean Patent Laid-Open the 10-2012-0117609th, Korean Patent Laid-Open the
No. 10-2013-0091662, Korean Patent Laid-Open the 10-1200396th etc..
Prior art literature
Patent document
Patent document 01:Korean Patent Laid-Open the 10-2011-0003532nd
Patent document 02:South Korea logs in special permission the 10-1132841st
Patent document 03:Korean Patent Laid-Open the 10-2012-0117609th
Patent document 04:Korean Patent Laid-Open the 10-2013-0091662nd
Patent document 05:Korean Patent Laid-Open the 10-1200396th
The content of the invention
For solving the above problems it is an object of the present invention to provide the following barbed suture coated with metal, lead to
Cross and synthesize the metallics components such as high gold, silver, titanium in the surface of barbed suture coating organism, to suppress the machine of barbed suture
The enhancement of tool physical property and barbed suture are directly contacted with body fluid so that the resolving time of elongated strap prickseam line, also, pass through to
The particle inside barbed suture is contained in constant interval and injects inhibiting substances, the support of the barbed suture of piercing can be increased
Power, by making skin elasticity enhancing improve the wrinkle of skin surface, and will be pierced into trouble in surgical procedure is lifted for skin
The side effect at place minimizes.
Of the invention one for reaching above-mentioned purpose is characterized in that the barbed suture coated with metal, above-mentioned coated with gold
The barbed suture belonged to includes:Barbed suture, with relative to the shape shape of the length direction of monofilament thread obliquely partial cut
Into the inside in the one or both sides of monofilament thread, being pierced into skin;Metal coat film, passes through the table in above-mentioned barbed suture
Face evaporation metal ion or metallic form;And multiple particles, the inside of above-mentioned barbed suture is contained in constant interval,
Being capable of caused side effect after performing the operation for suppression.
The one of the present invention is characterized in that the barbed suture coated with metal, in the one side of above-mentioned barbed suture, but does not limit to
In one side, along the length direction of above-mentioned barbed suture formed with being located at multiple thorn portions of inclined configuration partial cut, particle
The inside in above-mentioned thorn portion or the inside of each barbed suture for cutting rear place equivalent to above-mentioned thorn portion.
The one of the present invention is characterized in that the barbed suture coated with metal, above-mentioned particle state spherical in shape, in gel state,
And formed by the compounding substances of aloe and gooseberry fruit.
The one of the present invention is characterized in that the barbed suture coated with metal, and side effect mortifier is contained in the inside of above-mentioned particle
Matter, above-mentioned side effect inhibiting substances include tomato, Boston ivy, saururus chinensis, broccoli, garlic, thorn bark of a cork tree (Berberis
Vulgaris), hypericum erectum class (Hypericum perferforatum), the skin of willow (Salix caprea) stem, folium urticae,
Burdock leaf, cade oil, peppermint (Mentha arvensis), the leaf of Asiatic plantain (Plantago major), german chamomile
At least one of the flower of (Romashka, Chamomillarecutita), the seed of garden sorrel (Rumex acetosa) material into
Point;Above-mentioned side effect inhibiting substances are also comprising hyaluronic acid (HA, hyaluronic acid), Poly L-lactic acid (PLLA, poly-
L-lactic acid), at least one of calcium hydroxy apetite (CaHA, calcium hydroxylapatite) component material
Component.
The one of the present invention is characterized in that the barbed suture coated with metal, and above-mentioned metal coat film passes through above-mentioned barbed
Surface coating at least one of gold, silver or titanium the component material composition of suture forms.
The one of the present invention is characterized in that the barbed suture coated with metal, by varying the thickness of above-mentioned metal coat film
Degree, to adjust the residence time of the barbed suture of piercing in vivo.
As described above, the barbed suture coated with metal of the present invention has the metal coat by being formed at suture surface
Film promotes mechanical properties, and maintains the effect of the continuation of suture by the contact with body fluid.
Also, the present invention the barbed suture coated with metal with can by be pierced into the barbed suture inside skin with
The effect that the wrinkle for being formed at skin surface is removed by the constant date.
Also, the present invention the barbed suture coated with metal with can by be pierced into the barbed suture inside skin with
And realize the pulling function of skin by the constant date, so as to prevent the effect that skin surface sinks.
Also, the barbed suture coated with metal of the present invention has the life that can promote collagen inside skin
Into promotion hormone secretion, so as to regenerate skin function with skin activity, to improve the effect of beautifying skin.
Meanwhile the barbed suture coated with metal of the invention has and can minimally press down in surgical procedure is lifted
It is made as being possible to such as edema, bleeding, pain, extravasated blood trace, the inflammation factor of the side effect as caused by skin is pierced into position, and
The cure rate of side effect can be improved and cure the effect for improving speed.
Brief description of the drawings
Fig. 1 is the stereogram of the connection status of the barbed suture and needle part coated with metal of the diagram present invention.
Fig. 2 is the stereogram of the barbed suture coated with metal shown in pictorial image 1.
Fig. 3 is as the longitudinal sectional view in the incision section of the barbed suture coated with metal shown in an embodiment pictorial image 2.
Fig. 4 is to be cutd open as the longitudinal direction in the incision section of the barbed suture coated with metal shown in another embodiment pictorial image 2
View.
Fig. 5 is the figure of the piercing state of the barbed suture coated with metal shown in pictorial image 4.
Fig. 6 is the skin section stereogram that barbed suture of the diagram coated with metal is pierced into the state inside skin.
Fig. 7 removes the wrinkle of skin surface for expression by being pierced into the barbed suture coated with metal inside skin
The state diagram of the skin surface change of change.
Fig. 8 is the state diagram of the face of state before representing the barbed suture piercing coated with metal.
Fig. 9 is the state diagram of the face of state after barbed suture of the expression coated with metal is pierced into.
The explanation of reference numeral
100:Barbed suture 110:Thorn portion
120:Metal coat film 130:Particle
140:Inhibiting substances 200:Needle part
210:Fixed component 220:Handle
Embodiment
It will be clear that attached drawing in the present invention in order to illustrate definition and convenience and illustrated by exaggeration, it is aftermentioned
Embodiment do not limit protection scope of the present invention, but be pertaining only to proposed in the claimed scope of invention of the present invention
The illustrative item of structural element, should be based in view of with the skill of the specification full text of mutually different various forms deformation implementation
Art thought is explained.
Meanwhile in present invention below, it is not limited to embodiment, should be only by including based on described in specification full text
The invention of expansion scope explained of technology contents scope identification is claimed.
Hereinafter, the barbed suture coated with metal of the preferred embodiment of the present invention is described in more detail with reference to.
As shown in Figure 1, the barbed suture 100 of the present invention can be by by needle part 200, fixed component 210, handle 220
The piercing instrument of composition is pierced into inside skin, and above-mentioned needle part 200 is connected with above-mentioned barbed suture 100, barbed for that can make
Suture is flow into inside skin, and fixation portions part 210 by above-mentioned barbed suture in the state of above-mentioned needle part is fixed on, gradually
Needle part rear is gradually pushed to, and releases the fixation of barbed suture, above-mentioned handle 220 is combined with needle part rear, for energy
Enough fingers that surgical staff is adjusted in a manner of making needle part 200 be pierced into exactly inside skin.
As shown in Fig. 2, above-mentioned barbed suture 100 is by alongst with the thorn shape of constant compartment incision
Thorn portion 110 is formed, on the other hand, as shown in figure 3, including the metal coat film 120 coated on barbed 100 surface of suture.
Above-mentioned thorn portion 110 can by the length direction along barbed suture 100 in a manner of being not limited to one side partial cut
Morphosis.
In figs. 2 and 3, thorn portion 110 is formed along the one side and another side length direction of barbed suture 100, this
It is only used as an example and proposes.
It is, of course, preferable to ground, forms thorn portion 110, this is along the one side and another side length direction of barbed suture 100
Because in the case that thorn portion 110 is formed to the face in addition to the one side of barbed suture 100 and another side, it is being pierced into skin
During can cause pain, and when only the one side in the one side and another side of barbed suture 100 forms thorn portion 110,
Do not cause pain during skin is pierced into, but be difficult to expect that the skin to 110 another side of thorn portion in skin inside is lived
Property.
I.e., most preferably, form thorn portion 110 along the one side and another side length direction of barbed suture 110, this
Also demonstrated that in clinical trial results value.
Above-mentioned metal coat film 120 can with by metal ion or metallic evaporation in above-mentioned barbed 100 table of suture
The mode in face applies.Certainly, application pattern is not limited to the mode of above-mentioned evaporation, including various application patterns.
The barbed suture 100 formed as described above utilizes above-mentioned piercing instrument, and is pierced by the operation of surgical staff
Enter inside skin, in this case, barbed suture 100 performs the effect inside filling skin, and performs and push to formed with wrinkle
Skin surface direction effect.That is, by pushing skin surface direction to, smoothing wrinkle can be carried out.
Acting on to promote the generation of collagen for the above-mentioned execution of thorn portion 110 stimulation skin inside cell, thus, strengthens skin
Cell in skin, helps skin elasticity, and performs the pulling function inside skin to prevent skin from sinking.
Also, above-mentioned metal coat film 120, which performs, prevents the function of directly contacting of barbed suture 100 and body fluid to help
The lasting maintenance of barbed suture 100 is helped, and skin activity is contributed to by promoting hormone secretion.
Above-mentioned metal coat film 120 can be formed by the metallics of Jin Heyin or titanium, especially, above-mentioned metal coat film
In the case that 120 are formed by gold, be conducive to based on neural stabilization and the purification of the skin of noxious material detoxication.
As metal coat film 120, gold is coated on the surface of barbed suture 100, and in the case of being pierced into skin inside,
Promote the blood circulation based on ionization, so as to preventing skin aging and except removing chloasma is also effective.
Also, the barbed suture 100 coated with gold can provide skin by the tension force to work inside skin on surface
Elasticity.
In other words, after the barbed suture 100 of composition metal coat film 120 is as flowing into inside skin, promote
The implantation silk of cell implantation, using the implantation silk of polydioxanone (PDO) component safe to the human body, and with generating collagen egg
In vain, increase skin elasticity, improve the effect for the supporter that color and other effects is together performed as the implantation for helping cell.
The gold that purity is 99.9% promotes the blood circulation based on ionization, so as to help to prevent skin aging and remove
Removing chloasma, and the skin activity because being promoted based on hormone secretion and to preventing wrinkle of skin and removing freckle etc. effectively, and
Because of the Wound healing based on detoxication to preventing chafing and treatment acne effective, and reinforced immunological function.Also, by
It is almost like in the micro-current in the electric current and human body that golden hair goes out, thus make the metabolic activities in the function of cell tissue
Change, so that skin function regenerates.
Form the barbed suture 100 of this metal coat film 120 stimulates Skin Cell by thorn portion 110, and is based on
Chi structure activates collagen, so as to improve skin regeneration, skin elasticity and wrinkle with remarkable effect.
Above-mentioned barbed suture 100 also can by flow into behind skin inside by body fluid dissolving polyglycolic acid (PGA,
Polyglycolic acid) and polydioxanone (PDO, Polydioxanone) blending constituent composition, also can by these into
Point one or more of component composition.
On the other hand, skin protects periphery toxicant and human body, and prevent moisture from steaming as organ maximum in human body
Hair.This skin is made of Liang Ge organized layers, but as shown in fig. 6, one of them is by angling and to form the epidermis of layer, another
Basalis for the corium conjunctive tissue enriched as the collagen for providing nutrition.
The operation that above-mentioned barbed suture 100 is pierced into inside the skin formed as described above is by having flow into wrinkle
And the position followed the string pulls the operation of loose skin.
Due to different from existing operation, just absorbed completely after 3~6 months, and the proof gold being inserted into is nanoparticle
The size of son, thus in vivo in absorbed at leisure, promote ionization and blood flow, and be absorbed to internal proof gold and pass through sweat
It is rejected to naturally with urine external.
Therefore, the barbed suture 100 of metal coat film 120 of the surface coated with above-mentioned proof gold etc can not only prevent
Skin aging and wrinkle, and the micro-current in the golden hair electric current and human body that go out is almost like, so that in the function of cell tissue
Metabolic activities, and then regenerate skin function.
Also, the barbed suture 100 proposed in the present invention is different from existing infusible line, has and connect with body fluid
The property touched and melted, therefore absorbed completely in vivo, it is different from the prior art for being stored in face after operation for a long time,
So as to solve the problems, such as unexpected side effect.
It is not particularly limited using the operative site of the barbed suture 100 of the present invention, but usually in forehead, glabella, eye
Side, eight word wrinkle parts, eyeground, chin portion, chin, mouth position carry out, and can substantially enumerate face.
In the present invention, in order to increase advantage possessed by gold, combine metal coat film and polyglycolic acid (PGA,
Polyglycolic acid) suture material, so as to improve the beauty of skin, and improve wrinkle.
I.e., for the present invention, the raw material of barbed suture 100 is very safe material, thus is promoted under skin
The synthesis of collagen, and because of the interaction of the fine painting deposit with below 0.1mm, collagen occurs under skin
Synthesis and reset, also, postpone skin aging, and the colour of skin brightens while wrinkle is thin out.
Using the surgical procedure of barbed suture 100 of the invention as shown in fig. 6, barbed suture 100 is inserted in skin corium
Under, and this can be also sufficiently carried out by local anaesthesia, only carry out sleep anesthesia in special circumstances.
By once performing the operation, effect can be long lasting for can also carry out re-treatm ent.Surface is coated with metal coat film
120 barbed suture 100 is performed the operation as using the simple of needle part 200, when needing 1 small when carrying out whole face surgery
Left and right.Certainly, can not only perform the operation in face, can also be in the body needed for neck or the back of the hand for sinking and following the string etc.
Perform the operation position.
It is a feature of the present invention that existing spun gold (below 0.1mm) is overcome under small tension force by barbed suture
The shortcomings that leading to not be inserted separately into easily is broken, so as to flow into skin, does not have the worry easily broken when operation,
Metal coat film 120 stimulates skin during being adapted to inside skin, thus strengthens surgical effect, and realizes maximization.
Metal coat film 120 is inserted in skin, and induces the foreign body reaction in human body, so as to pass through natural collagen protein
Generation and flourishing improvement skin blood with capillary in skin.This collagen is not forcibly to flow into skin
It is interior, but voluntarily generated in skin, thus it is non-artificial generated, be that nature is generated, also, its effect it is lasting when
Between it is also elongated.Thus, smoothing wrinkle naturally, there is provided skin elasticity, and improve the colour of skin.
As shown in fig. 7, improve wrinkle before comparing the barbed suture 100 that the present invention is injected in skin and after injection
Situation, it is known that be clearly not available improvement.
As shown in fig. 6, the metal coat film 120 of (subdermis) is inserted under skin corium by foreign body reaction in week
Side promotes the generation of capillary, this improves the blood circulation of skin, so as to supply periphery cytotrophy, having makes the colour of skin brighten
Effect.
Also, metal coat film 120 can strengthen the work of fibroblast (Fibroblast) with artificial monofilament difference
Property, persistently promote the generation of collagen, and wet end is inserted in, so as to improve the supporting degree of skin.
For existing rhytidectomy, wrinkle or insertion adminicle are only pulled to hide wrinkle, rather than improve skin.
The blood circulation on skin periphery is improved using the operation of the barbed suture 100 of the present invention, improves the nutrition supply of periphery cell, makes
Face improves, and skin elasticity is improved because of the generation based on collagen, so as to prevent aging, and improves skin.
Also, certainly, metal coat film 120 optionally changes its thickness, to adjust the barbed suture 100 of piercing
Residence time in skin volume.
On the other hand, implement to be pierced into operation and another rhytidectomy using the skin of the barbed suture of the present invention, and compare
The difference of two kinds of operations.
Using 40 patients as object, 10 patients are carried out to be pierced into operation using the skin of the barbed suture of the present invention,
10 patients have been carried out with the magic rhytidectomy as another rhytidectomy, face lift art has been carried out to 10 patients, to 10
Name patient has carried out clostridium botulinum operation.
Following table 1 to be compared with the skin of the barbed suture of present invention piercing operation and another kind rhytidectomy, (remove by magic
Wrinkle art, face lift art, clostridium botulinum) table.
Table 1
A B C D
Skin
It is smooth without no that the cosmetic result colour of skin brightens, skin softens
The duration lasts of beautifying skin effect
Continue within more than 5 years
Continue within 2~3 years
Continue within 3~4 years
4~6 months
Operation
Required time needs
Need within 50 minutes or so
1 more than hour needs
Or so 2~3 hours need
10~20 minutes or so
Anesthesia part anesthesia part anesthesia whole body or part anesthesia need not anaesthetize
Scar is produced without no part nothing
Swell,
Extravasated blood green grass or young crops block faint 15 days~2 months
Nothing during recovery
Unnecessary portion needs part to need to be not required during recovery
In above-mentioned table 1, A is to be pierced into operation using the skin of the barbed suture of the present invention, and B is magic rhytidectomy, and C is face
Art is lifted, D is clostridium botulinum.
Such as observe above-mentioned table 1 and understand that the duration of beautifying skin effect and beautifying skin effect is most important, and be terrible
To the beneficial part to this beautifying skin effect and the duration of beautifying skin effect, whole synthesis operation is taken
Between, anesthesia, produce scar, swell and extravasated blood green grass or young crops block, recover during when consider when, utilize the present invention barbed suture skin thorn
Enter to perform the operation excellent.
Certainly, equivalent to operation the time required to, anaesthetize, swell with the key element of extravasated blood green grass or young crops block, although the clostridium botulinum with D
Compared to reduction, but when compared with the duration of beautifying skin effect and beautifying skin effect, it is known that utilize the barbed of the present invention
It is obvious prominent that the skin of suture is pierced into operation.
According to the actual barbed suture using the present invention come the photograph before the operation of the patient to undergo surgery and after operation
Piece, observes the patient face before the operation of Fig. 8, it is known that eight word wrinkle positions are substantially exposed, and observe the trouble after the operation of Fig. 9
Person face, it is known that wrinkle is improved, and reaches the degree that almost can not find eight word wrinkle positions.In other words, it is to utilize this hair
The operation of the barbed suture of bright proposition, thus obtain such as the result of above-mentioned table 1.
As described above, the barbed suture coated with metal of the present invention is by being formed at the metal coat film of suture surface
To promote mechanical properties, suppress the contact with body fluid, so as to maintain the continuation of suture, also, by being pierced into skin
The barbed suture in portion is formed at the wrinkle of skin surface with improving by the constant date, and skin is prevented by skin pulling function
Skin Surface Subsidence, and promote generation and the hormone secretion of collagen, so that regenerate skin function by skin activity, with
Improve beautifying skin.
On the other hand, as shown in Figures 4 and 5, the multiple particles 130 being contained in inside above-mentioned barbed suture 100 are rounded
Spherical state, in gel state.
It is to easily inject side effect inhibiting substances to the inside of particle 130 above-mentioned particle 130 is in gel state
140, and inhibiting substances 140 is flowed out after the procedure from the position of piercing.Here, after side effect refers to that lifting is performed the operation
It is possible to the symptom such as edema, bleeding, pain, extravasated blood trace, inflammation as caused by corresponding skin affected part.
That is, in the state of barbed suture 100 is not pierced into skin, particle 130 is preserved with gel state, therefore with injection
The advantages of inhibiting substances 140 inside particle 130 do not flow out, after, it is pierced into the state of skin in barbed suture 100
Under, with being folded over by pressure in skin and in thorn portion 110 pressure (F- > F ') produced in journey, the particle of gel state
130 are easily broken, and the inhibiting substances 140 in the skin of piercing easily flow out, and can constantly realize constant outflow.
Above-mentioned particle 130 is formed by the compounding substances of aloe and gooseberry fruit, and aloe promotes blood by pharmacological action
Circulation, improves soma liquid, and noxious material in decomposer.Also, strengthen antibacterial ability, and perform imparting to make body just
Normal cell forms the function of the ability of cell of same nature etc..
Above-mentioned gooseberry (Ribes nigrum) fruit includes vitamin C and other many vitamins, astringent component and enriches
Organic acid, these are adjoint materials during gel state is processed into.
Therefore, by the use of aloe and gooseberry fruit as the material for forming above-mentioned particle 130, can minimally reduce
The abnormal response for the skin that artificial material is pierced into the lifting surgical procedure of beautifying skin purpose, is pierced into affected part to corresponding skin and supplies
To the nutrition of appropriate amount, so as to increase the histiocytic immunity to lifting operation affected part position, it is secondary that reduction can be contributed to
The drastically progress of effect.
On the other hand, tomato, Boston ivy, three white can be included by being contained in inhibiting substances 140 inside above-mentioned particle 130
Grass, broccoli, garlic, thorn bark of a cork tree (Berberis vulgaris), hypericum erectum class (Hypericum perferforatum), willow
The skin of (Salix caprea) stem, folium urticae, burdock leaf, cade oil, peppermint (Mentha arvensis), Asiatic plantain
Leaf, flower, the garden sorrel (Rumex of german chamomile (Romashka, Chamomilla recutita) of (Plantago major)
Acetosa seed).
Above-mentioned thorn bark of a cork tree (Berberis vulgaris) is used as invaluable food plant and medicinal plant, the fruit of tart flavour
Real edible, it can also be used to prepare jam, beverage, condiment etc..
Above-mentioned hypericum erectum class (Hypericum perferforatum) conduct long ago starts just known in western medicine
Medicinal plant, medicinal herbs will be used as to the part exposed on the ground, can be when tying flower and while blooming be collected as medicinal herbs.
The root and skin of above-mentioned willow (Salix caprea) are used as the medicinal herbs of drop heat, especially, obtained from heated leaching
Soup can be utilized as the purposes of hair washing.
Above-mentioned nettle (Urtica dioica) is used as valuable food plant and medicinal plant, contains very in folium urticae
Multivitamin (vitamin C, carrotene etc.), in addition containing protein, starch, sugar, organic acid, molysite, potassium etc..
The root of above-mentioned burdock (Arctium lappa) is used as medicine, especially, is used as vegetables in South Korea, China and Japan, and
Seed is known as disliking in fact on Chinese herbal medicine, and is utilized as medicinal material.
Above-mentioned needle juniper (Juniperus communis) is distributed widely in European Region and the Siberia of Russia, in pine
Contain essential oil, a variety of sugars, organic acid, resin etc. in the fruit of spherical shape.
Above-mentioned peppermint (Mentha arvensis) is used in the disinfectant or analgestic, cold injury treatment of flu or antimigraine
With the preparation of menthol solutions, dried peppermint leaf is used for neuralgia, coughs, removes phlegm etc..Especially, it is used for tuberculosis and stomach in Tibet, peppermint
Enteropathy, is utilized as analgestic in terms of spasm or rheumatism and arthritis, antiphlogistic is utilized as in terms of skin disease.
Above-mentioned german chamomile (Romashka, Chamomilla recutita) is as starting to function as medicinal herbs from way back
Plant, is used as medicinal material by the flower of above-mentioned german chamomile.
In garden sorrel (Rumex acetosa), the blade of tart flavour is especially well known food plant.Containing a variety of in sorrel
Oxalic acid, mineral salt, protein, vitamin etc..
Above-mentioned tomato, Boston ivy, saururus chinensis have effects that to eliminate edema, therefore any of these can be used, excellent
Selection of land, using juice, so as to the rapid edema for eliminating the affected part position being pierced into.
Above-mentioned broccoli and garlic have the abundant bata-carotene component for being used to make the unobstructed blood of cohesion, therefore usable
Any of these, it is preferable that using juice, so as to the rapid extravasated blood trace for eliminating the affected part position being pierced into.
As described above, mix from above-mentioned tomato, Boston ivy, saururus chinensis, broccoli, garlic, thorn bark of a cork tree (Berberis
Vulgaris), hypericum erectum class (Hypericum perferforatum), the skin of willow (Salix caprea) stem, folium urticae,
Burdock leaf, cade oil, peppermint (Menthaa rvensis), the leaf of Asiatic plantain (Plantago major), german chamomile
The juice that flower, the seed of garden sorrel (Rumex acetosa) of (Romashka, Chamomilla recutita) obtain, to form
The inhibiting substances 140 that the side effect in the corresponding affected part to lifting operative site can be minimized.
The barbed suture for the particle 130 for being injected with the inhibiting substances 140 formed by mixing juice as described above will be included
100 products are assumed to be the experimental group of the present invention, and respectively assume the general barbed suture product of no inhibiting substances and particle
For existing control group A, control group B, with 30 entitled object of men and women of being grown up, using testing the barbed suture of set product come to 10
Lifting operation is implemented, other 10 are implemented with lifting operation using the barbed suture of control group A product, and utilize control group B
The barbed suture of product implements lifting operation to remaining 10, and is used as its clinical trial results, has obtained such as following table 2
End value.
Table 2
Incidence of side effects remarks
Experimental group 10% is adapted to as operation without side-effects
Control group A 50% is not suitable for as operation without side-effects
Control group B 60% is not suitable for as operation without side-effects
In the case of experimental group A equivalent to the barbed suture 100 of the present invention, in the skin equivalent to lifting operative site
During the barbed suture 100 of interior piercing, as shown in figure 5, thorn portion 110 and metal coat film 120 are clipped in skin tissue cell, and pass through
Strong castering action, is housed in the particle 130 inside the barbed suture 100 equivalent to thorn portion rear position and is based on F->The work of F '
Crushed, and be cracked with pressure (power), and consistently flowed out by this cracking gap, inhibiting substances 140, and can incited somebody to action
The side effect at affected part position minimizes.
Certainly, it is pierced into and all include the barbed suture of the component being made of above-mentioned inhibiting substances 140, and piercing is wrapped repeatedly
Containing the experimentation for removing the barbed suture of remaining component after a part of component one by one successively from inhibiting substances.
In the process, it is pierced into the barbed suture comprising the residual components in addition to tomato, Boston ivy, Chinese lizardtail rhizome
In the case of, significant edema occurs being pierced into affected part position.
On the other hand, it is known that be pierced into the situation of the barbed suture comprising the residual components in addition to broccoli and garlic
Under, significant extravasated blood trace occurs being pierced into affected part position.
Also, understand to be pierced into the barbed suture comprising the residual components in addition to piercing the seed of bark of a cork tree, folium urticae, garden sorrel
In the case of, bleeding occurs being pierced into affected part position, is pierced into the band prickseam for including the residual components in addition to peppermint and cade oil
In the case of line, serious pain occurs being pierced into affected part position, and be pierced into comprising except hypericum erectum class, burdock, willow stem
In the case of the barbed suture of residual components outside skin, inflammation becomes serious.
Therefore, in order to suppress lifted perform the operation when the side effect that occurs, as edema, bleeding, pain, extravasated blood trace, inflammation it
The key element of class, or improve to cure and recover, it is necessary to be pierced into the inhibiting substances of the juice all mixed comprising mentioned component.
Certainly, during the lasting surgical data accumulation of patient with operation, to prevent the one of side effect does not occur in few patients
The situation of partial element, optionally combines inhibiting substances, and proposes the barbed suture of mixing, so as to can also carry out indivedual hands
The Custom Prosthesis operation of art patient.
As shown in Table 2 above, in the case of being performed the operation by being pierced into the barbed suture comprising inhibiting substances, mortifier
Matter can would be possible to the side effect as caused by corresponding affected part position and minimize, therefore can significantly reduce side effect
Incidence, on the contrary, in the case of being performed the operation by being pierced into general barbed suture not comprising this inhibiting substances, have
It is possible to the quite high worry of incidence of the side effect as caused by corresponding affected part position.
Also, in following experimental example, using the barbed suture of the present invention, the barbed suture of control group A, control group B band
Prickseam line, state of progress is cured to grasp the skin affected part of the white mouse of the investing method based on inhibiting substances.
Experimental example:The affected part of investing method based on inhibiting substances cures state of progress
This experimental example cures state of progress to prove the input of the inhibiting substances of the present invention for the affected part of 300 white mouse of grasp
The experiment of mode brilliance.
That is, after cutting the skin of 300 white mouse respectively with identical size, the barbed of the present invention is injected to 100 white mouse
Suture (includes the particle for being injected with inhibiting substances), and (coating is included to the barbed suture of other 100 white mouse injection control group As
In the inhibiting substances of barbed suture surface), and (do not include mortifier to the barbed suture of remaining 100 white mouse injection control group B
Matter), to check the healing state of progress in affected part with time going by.
Here, since the barbed suture of above-mentioned control group B does not include inhibiting substances, thus have selected and injecting barbed suture
Afterwards, in the mode of skin affected part surface coating inhibiting substances.
Table 3
Affected part with time going by cures state of progress rate (%)
As shown in Table 3 above, it is known that with time going by, in experimental group, the histocyte in corresponding affected part cure into
Exhibition state is with by curing to obtain faster state compared with Time constant, on the contrary, in the case of control group A, and by Time constant
Compared to curing state of progress imperfection, in the case of control group B, untill by 60 minutes, it is very fast to cure state of progress, and
After 60 minutes, it is slow on the contrary to cure state of progress.
That is, in experimental group, using the barbed suture 100 for the form for housing the particle 130 for being injected with inhibiting substances 140, come
Inhibiting substances 140 are with constant basis is persistently flowed out from particle 130 and is possible to send out in respective organization cell when suppressing lifting operation
Raw side effect, and the state of progress normally cured can be made rapid.
In other words, the extra emergency disposal of reply side effect is only excessively performed after lifting operation, can
Improve inconvenience.
On the contrary, understand, in the case of control group A, carried out using in barbed suture of the surface coated with inhibiting substances 140
During lifting operation, inhibiting substances are flowed directly out from the surface of barbed suture, and are possible to dilute with histocyte liquid, thus cannot
It is enough thoroughly to suppress side effect, and state of progress is cured also with the time by being deteriorated.
On the contrary, understanding, in the case of control group B, carried using the general barbed suture for being not coated with being covered with inhibiting substances
When rising operation, due to using by the way of being pierced into affected part surface and applying inhibiting substances, thus with time going by, suppressing
A large amount of Evaporation Phenomenons of material, when starting 30 minutes to 60 minutes, healing makes fast progress (increase), but after 60 minutes, due to
Inhibiting substances deficiency, it is relatively slow (reduction) to cure progress.
The end value of above-mentioned table 2 and table 3 is analyzed, it will be clear that by the inhibiting substances of the present invention, will can be lifted
The side effect as caused by corresponding skin affected part (edema, extravasated blood green grass or young crops block, bleeding, pain, inflammation etc.) minimum is possible to after operation
Change.
I.e., it is known that, as inhibiting substances, tomato, Boston ivy, Chinese lizardtail rhizome have effects that eliminate edema, broccoli and
Garlic has effects that elimination extravasated blood trace, and thorn bark of a cork tree, folium urticae, the seed of garden sorrel have effects that hemostat, peppermint and cade oil tool
There is the function of alleviating pain, hypericum erectum class or the leatherware of burdock and willow stem have the effect of improving inflammation.
On the other hand, above-mentioned inhibiting substances can also include hyaluronic acid (HA, hyaluronic acid), gather left-handed breast
One in sour (PLLA, poly-L-lactic acid), calcium hydroxy apetite (CaHA, calcium hydroxylapatite)
The material of the kind above.
Above-mentioned hyaluronic acid (HA, hyaluronic acid) as be present in more internal skin, vitreum, joint fluid,
The component of cartilage etc., its hydrophily is very prominent, can infiltrate 1000 times of moisture of weight itself.That is, have until attracting
Periphery hydrone maintains untill the hyaluronic acid of volume largely decomposes, to be able to maintain that skin elasticity and moisture, or expect
The advantages of lubricating action in joint.Certainly, hyaluronic acid can also be used to suppress the component of inflammation and bleeding.
For above-mentioned Poly L-lactic acid as the component for improving wrinkle by stimulation collagen in vivo, can be used as can be from
The single water base tartaric acid (AHA) obtained in plant is absorbed again, is suitable for the synthetic polymer of organism, be decomposed into water,
Carbon dioxide and lactic acid, so as to safety and can be absorbed to internal, can also be utilized as being possible to be pierced into affected part in skin
Wound covering therapeutic agent.
The one kind of above-mentioned calcium hydroxy apetite as bone component, is chiefly used in fracture site or placement in surgical field
It is the synthetic mineral matter component identical with bone, tooth in the material on bone, thus can feels hard, and the increase production to volume
Raw more favourable effect, it is thus possible to contribute to the increase of skin elasticity.
As described above, above-mentioned hyaluronic acid (HA, hyaluronic acid), Poly L-lactic acid (PLLA, poly-L-
Lactic acid), calcium hydroxy apetite (CaHA, calcium hydroxylapatite) component flow into skin layer, and
Play and suppress the effect that barbed suture moves in skin, thus, contribute to barbed suture to ensure skin inner support power, and promote
The generation of the histiocytic collagen of surrounding skin.
Collagen as composition skin, cartilage, muscle etc. conjunctive tissue basal protein, during skin aging, collagen
The growing amount of albumen is reduced, so that skin volume loses, skin elasticity declines, thus can not in order to tackle above-mentioned metallics
The effect of itself is performed, inhibiting substances can also include above-mentioned hyaluronic acid (HA, hyaluronic acid), Poly L-lactic acid
In (PLLA, poly-L-lactic acid), calcium hydroxy apetite (CaHA, calcium hydroxylapatite) component
More than one component.
As described above, hyaluronic acid (HA, hyaluronic acid), Poly L-lactic acid (PLLA, poly-L- will be included
Lactic acid), the material of one or more of calcium hydroxy apetite (CaHA, calcium hydroxylapatite) component
The inhibiting substances of component are assumed to be the barbed suture of experimental group, will not include above-mentioned hyaluronic acid (HA, hyaluronic
Acid), Poly L-lactic acid (PLLA, poly-L-lactic acid), calcium hydroxy apetite (CaHA, calcium
Hydroxylapatite) the barbed suture of component is assumed to be the barbed suture of control group A, and will not include inhibiting substances at all
Barbed suture be assumed to be the barbed suture of control group B, the barbed suture of above-mentioned experimental group is pierced into 30 white mouse, to other
30 white mouse are pierced into the barbed suture of above-mentioned control group, and the barbed suture of control group B is pierced into other 30 white mouse, by perseverance
After fixing time, the state of internal barbed suture is observed.As a result, the end value of following table 4 is obtained.
Table 4
Experimental group control group A control group B
(100~80%) zero on support force (%)
(80~60%) zero in upper
In (60~40%)
In under (40~20%)
Under (20~0%) zero
(100~80%) zero on the production rate and skin elasticity (%) of collagen
(80~60%) zero in upper
In (60~40%)
In under (40~20%)
Under (20~0%) zero
As shown in Table 4 above, it is known that, compared with control group A, in experimental group, the branch for the barbed suture being pierced into skin
Support force, the production rate of collagen and skin elasticity are relatively large, and control group A is pierced into barbed in skin compared with control group B
The support force of suture, the production rate of collagen and skin elasticity are with respect to higher.
That is, compared with control group A, the support force of barbed suture, the production rate of collagen and skin elasticity increase experimental group
Add, its reason is distinguished as follows:Since inhibiting substances are also comprising hyaluronic acid (HA, hyaluronic acid), Poly L-lactic acid
In (PLLA, poly-L-lactic acid), calcium hydroxy apetite (CaHA, calcium hydroxylapatite) component
More than one material, therefore can be with these material compositions (hyaluronic acid, Poly L-lactic acid, calcium hydroxy apetite) to metal
The effect that unexpected abnormal response of the material (gold, silver or titanium) with skin tissue cell is offset is related, and with order to tackle
Metallics can not perform the function of itself, it is ensured that support force, generates collagen, and the effect for increasing skin elasticity has
Close.
Stated differently, since above-mentioned hyaluronic acid, Poly L-lactic acid, hydroxyapatite calcium component are naturally raw in vivo
Into material, thus even if flowing into in-vivo tissue cell, the activity of in-vivo tissue cell can be also contributed to normal reaction
Change.
Certainly, even if inhibiting substances 140 are also comprising one in hyaluronic acid, Poly L-lactic acid, hydroxyapatite calcium component
In the case of the material composition of kind of the above, also can more suppress to be pierced into skin affected part side effect (edema, extravasated blood green grass or young crops block,
Bleeding, pain, inflammation etc.), and the treatment more improved to affected part recovers tempo.
On the other hand, if above-mentioned inhibiting substances 140 are also comprising hyaluronic acid, Poly L-lactic acid, hydroxyapatite calcium component
One or more of material composition, although it is not shown, but also house particle 130 in the inside in thorn portion 110, also can be to this
Grain 130 injects hyaluronic acid, Poly L-lactic acid, the component of calcium hydroxy apetite.
It is thus impossible to expect that the metal coat film 120 coated on 110 surface of thorn portion plays the work of itself in skin
Used time, by flowed out from the particle 130 being contained in inside thorn portion 110 hyaluronic acid, Poly L-lactic acid, calcium hydroxy apetite
Component, it can be ensured that support force, increases skin elasticity, and generates collagen.
Claims (4)
- A kind of 1. barbed suture coated with metal, it is characterised in that including:Barbed suture, monofilament thread is formed at the shape relative to the length direction of monofilament thread obliquely partial cut One or both sides, be pierced into the inside of skin;Metal coat film, is formed by the surface evaporation metal ion or metallic in above-mentioned barbed suture;AndMultiple particles, the inside of above-mentioned barbed suture is contained in constant interval, can be caused secondary after performing the operation for suppression Effect, wherein,Above-mentioned particle state spherical in shape, forms in gel state, and by the compounding substances of aloe and gooseberry fruit,Side effect inhibiting substances are contained in the inside of above-mentioned particle, and above-mentioned side effect inhibiting substances include tomato, Boston ivy, three white Grass, broccoli, garlic, thorn bark of a cork tree, hypericum erectum class, the skin of willow stem, folium urticae, burdock leaf, cade oil, peppermint, Asiatic plantain leaf, At least one of the flower of german chamomile, the seed of garden sorrel material composition;Above-mentioned side effect inhibiting substances are also comprising at least one of hyaluronic acid, Poly L-lactic acid, hydroxyapatite calcium component Material composition.
- 2. the barbed suture according to claim 1 coated with metal, it is characterised in that the one of above-mentioned barbed suture Face, but one side is not limited to, along the length direction of above-mentioned barbed suture formed with multiple thorns of inclined configuration partial cut Portion, particle are located at the inside in above-mentioned thorn portion or the inside of each barbed suture for cutting rear place equivalent to above-mentioned thorn portion.
- 3. the barbed suture according to claim 1 coated with metal, it is characterised in that above-mentioned metal coat film passes through On the surface of above-mentioned barbed suture, coating at least one of gold, silver or titanium component material composition forms.
- 4. the barbed suture coated with metal according to claim 1 or 3, it is characterised in that by varying above-mentioned metal The thickness of film is applied, to adjust the residence time of the barbed suture of piercing in vivo.
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KR101645541B1 (en) * | 2016-05-12 | 2016-08-04 | 김성남 | Volume Thread for Lips |
TWI622378B (en) * | 2017-04-27 | 2018-05-01 | 鄧守成 | Surgical thread |
KR20190122314A (en) | 2018-04-20 | 2019-10-30 | 랩앤피플주식회사 | Skin-enhancing insert using the bioabsorbable metal |
JP7320301B2 (en) * | 2018-09-17 | 2023-08-03 | ラボエヌピープル カンパニー,リミテッド | Implant therapy rope and implant therapy needle device including the same |
KR102053392B1 (en) * | 2018-10-16 | 2019-12-09 | 주식회사 엠베이스 | Method for manufacturing medical suture for improving sexual function |
KR102346662B1 (en) * | 2019-06-25 | 2022-01-03 | 윤지혜 | Medical thread and producing method for the same |
CN112315623B (en) * | 2020-11-02 | 2022-01-18 | 成都迪康中科生物医学材料有限公司 | Self-fixing lifting wire for shaping and beautifying |
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RU2015102994A (en) | 2016-08-20 |
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