KR102346662B1 - Medical thread and producing method for the same - Google Patents

Abstract

Medical thread according to an embodiment of the present invention is formed of a first biodegradable material, the yarn including a plurality of projections protruding outward on the surface; and a first coating layer formed of a second biodegradable material different from the first biodegradable material, and completely surrounding the outer surface of the yarn.

Description

Medical thread and its manufacturing method

The present invention relates to a medical thread and a method for manufacturing the same.

Recently, as interest in skin beauty increases, various medical procedures for removing wrinkles are being performed.

These wrinkle removal procedures include Botox, which paralyzes muscle activity in the wrinkled area to eliminate skin movement, and incisional surgery, which removes saggy skin tissue by making an incision in the skin. However, there is a problem in terms of cost because Botox has to be administered periodically for a set period, and since the incisional procedure requires an incision of the skin, there is a problem that a lot of time is required for recovery.

In recent years, many lifting procedures to tighten the wrinkled area using injections or threads that can reduce these problems have been performed. The lifting procedure is a method that removes wrinkles and revitalizes the skin by inserting a specially prepared melting thread (Polydioxanone, PDO) into the skin tissue using a needle to be absorbed into the body by hydrolysis after a certain period of time has elapsed. . In general, the thread used for the lifting procedure is provided in a form in which hook-shaped protrusions are formed in a certain direction on the surface, as in Korea Utility Model No. 20-2018-0002952 No. 20-2018-0002952.

The hook-shaped protrusion provided on the surface of such a conventional lifting thread is usually formed in a manner that cuts the surface of the thread. The hook-shaped protrusion formed in this way imparts a fixing force to the melting thread, so that the skin tissue can be pulled in a desired direction, thereby resulting in a wrinkle improvement effect.

However, since the hook-shaped protrusion is formed through a physical method such as a sheathing method, a phenomenon in which the mechanical properties of the original melting thread material are reduced by a certain percentage may occur. In addition, by accelerating the hydrolysis of the melting thread, the quality of the product may be deteriorated. Moreover, due to the reduction in fixing force according to this, the duration of the lifting effect is lowered, there is a problem that the treatment cycle is reduced.

Patent Literature: Korean Utility Model Publication No. 20-2018-0002952 (2018.10.16. Announcement)

Embodiments of the present invention are proposed to solve the above problems, and to provide a medical thread capable of improving product stability and a manufacturing method thereof.

In addition, an object of the present invention is to provide a medical thread capable of preventing or alleviating side effects such as skin inflammation and a manufacturing method thereof.

In addition, an object of the present invention is to provide a medical thread capable of improving the continuity of the treatment effect and a method for manufacturing the same.

According to an embodiment of the present invention, a yarn formed of a first biodegradable material, comprising a plurality of protrusions protruding outwardly on the surface; and a first coating layer formed of a second biodegradable material different from the first biodegradable material, the first coating layer entirely surrounding the outer surface of the yarn may be provided.

In addition, the first biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) Any one of the medical threads may be provided.

In addition, the second biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) Any one of the medical threads may be provided.

In addition, the first coating layer and the thickness ratio of the yarn may be provided with a medical thread of 1:3000 to 1:3.

In addition, a medical thread provided with a second coating layer may be provided between the yarn and the first coating layer.

In addition, the second coating layer is provided with an anti-inflammatory material, and the anti-inflammatory material is a hydrophobic biodegradable polymer material including calcium stearate, PLA (Poly Lactic Acid), PGA, PLA/PGA copolymer, and PCL. , dexamethasone and gentamicin any one of a medical seal may be provided.

In addition, the second coating layer may be provided with a medical thread provided to surround the outer surface of the yarn before the projection is formed.

In addition, the plurality of protrusions may be provided with a medical thread in which the protrusion direction with respect to the longitudinal direction of the yarn is formed in the same manner.

In addition, the protrusion may be provided with a medical thread provided as a bed.

In addition, the forming angle of the projection with respect to the longitudinal direction of the yarn may be provided with a medical thread of 30 ° to 60 °.

On the other hand, according to another aspect of the present invention, there is provided a method for manufacturing a medical thread, comprising the steps of: preparing a yarn formed of a first biodegradable material; forming a plurality of projections on the yarn; and forming a first coating layer formed of a second biodegradable material different from the first biodegradable material on the outer surface of the yarn.

In addition, the first biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) Any one of the medical thread manufacturing method may be provided.

In addition, the second biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) Any one of the medical thread manufacturing method may be provided.

In addition, the step of forming the first coating layer may be provided with a method for manufacturing a medical thread through any one of a dip coating method, a spray coating method, and an ultrasonic coating method.

In addition, further comprising the step of forming a second coating layer provided between the yarn and the first coating layer, the step of forming the second coating layer is between the step of forming the projection and the step of forming the first coating layer A method for manufacturing a medical thread made in may be provided.

In addition, the second coating layer is provided with an anti-inflammatory material, and the anti-inflammatory material is a hydrophobic biodegradable polymer material including calcium stearate, PLA, PGA, PLA/PGA copolymer, PCL, dexamethasone, and gentamicin. Any one of the medical thread manufacturing method may be provided.

In addition, there may be provided a medical thread manufacturing method further comprising the step of drying the first coating layer.

In addition, there may be provided a medical thread manufacturing method further comprising the step of removing the toxicity of the medical thread.

According to embodiments of the present invention, a medical thread capable of improving product stability and a manufacturing method thereof may be provided.

In addition, a medical thread capable of preventing or alleviating side effects such as skin inflammation and a manufacturing method thereof may be provided.

In addition, a medical thread capable of improving the durability of the lifting effect and a manufacturing method thereof can be provided.

1 is a perspective view showing a medical seal according to an embodiment of the present invention.
FIG. 2 is a cross-sectional view showing a cross-section taken along line AA of FIG. 1 .
FIG. 3 is a cross-sectional view of a cross-section cut at BB according to the type of the first coating layer of FIG. 1 observed under a microscope.
4 is a graph showing the test results of measuring the maximum tensile stress over time according to the presence or absence of the first coating layer and the type of the first coating layer of the medical thread of FIG. 1 .
5 is a cross-sectional view of a medical seal according to another embodiment of the present invention.
6 is a flowchart illustrating a method for manufacturing a medical thread according to an embodiment of the present invention.
7 is a flowchart illustrating a method for manufacturing a medical thread according to another embodiment of the present invention.

Hereinafter, specific embodiments of the present invention will be described in detail with reference to the drawings.

In addition, in describing the present invention, if it is determined that a detailed description of a related known configuration or function may obscure the gist of the present invention, the detailed description thereof will be omitted.

1 is a perspective view showing a medical thread according to an embodiment of the present invention, and FIG. 2 is a cross-sectional view taken along line A-A of FIG. 1 .

The medical thread 1 according to the embodiment of the present invention is an absorbable thread, at least part of which undergoes physical and chemical changes in the body and is absorbed after a certain period of time, and is inserted into the skin tissue to tighten the skin. It can be used as an application. However, the spirit of the present invention is not limited thereto, and the thread may be used for other purposes within the scope of the present invention. For example, the medical thread 1 may be a thread used to seal a tissue damaged by surgery or trauma.

1 and 2 , the medical thread 1 may include a yarn 10 and a first coating layer 20 .

The yarn 10 is a component that has a predetermined rigidity and can be fitted into the skin tissue, and may be provided to apply a physical external force to the skin tissue or to maintain a state inserted into the skin tissue.

In this case, the yarn 10 may be formed of a first biodegradable material. In this embodiment, the biodegradable (Biodegradable) material means a material that is decomposed by being involved in the metabolism of organisms in at least one process of decomposition, and corresponds to a self-evident material already known to those skilled in the art, so a more detailed description is omitted. decide to do For example, the first biodegradable material constituting the yarn 10 is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide ( Poly-L-lactide, PLLA). Since the yarn 10 is formed of the first biodegradable material, it may be gradually lost over time by the action with the body.

A plurality of protrusions 11 protruding outwardly may be formed on the surface of the yarn 10 . The protrusion 11 allows the medical thread 1 to function to pull the skin or muscle tissue by being caught on the surrounding skin or muscle tissue when the medical thread 1 is inserted into the body. The medical thread (1) can be used in a lifting procedure that tightens the skin by forming such a protrusion (11). In this embodiment, it has been described that the projections 11 are formed three at the top and bottom based on the cross-sectional view of FIG. 2 , but the number of the projections 11 is not limited thereto, and the length or lifting strength of the medical thread 1 . may be formed differently. For example, in order to further increase the lifting strength, a larger number of protrusions 11 may be provided.

The plurality of protrusions 11 may be formed by cutting the outer surface of the yarn 10 . Specifically, by obliquely cutting the outer surface of the yarn 10, the protrusion 11 may be formed. However, the method of forming the protrusion 11 is not limited thereto. For example, the protrusion 11 may be formed together with the yarn 10 by a mold.

The protrusion 11 may be formed in a needle-like shape with a sharp tip. Since the protrusion 11 is formed in a pointed shape, there is an advantage that the protrusion 11 can be easily caught in the skin tissue. Accordingly, the lifting effect can be generated more effectively.

In this case, the angle of formation of the protrusion 11 with respect to the longitudinal direction of the yarn 10 may be provided in a range of 30° to 60°. When the angle of formation of the protrusion 11 is too small, the protrusion 11 does not easily catch on the skin tissue, and thus the lifting effect may be reduced. In addition, when the angle of formation of the protrusion 11 is too large, the protrusion 11 hanging from the skin tissue may be broken when the end of the medical thread 1 is pulled for lifting. The protrusion 11 of the medical thread 1 according to the present embodiment is formed at an angle of 30° to 60° with respect to the longitudinal direction of the yarn 10, so that the protrusion 11 can be easily caught in the skin tissue, , can improve the lifting effect.

Meanwhile, the plurality of protrusions 11 may be formed to have the same protrusion direction with respect to the longitudinal direction of the yarn 10 . That is, the plurality of projections 11 formed on the yarn 10 may each protrude in the same direction. Specifically, referring to FIG. 2 , the plurality of protrusions 11 may be provided in the form of protruding toward the left with reference to FIG. 2 . In this case, the medical thread 1 can be inserted into the facial skin tissue so that the right side of Fig. 2 is placed on the lower part of the face and the left side of Fig. 2 is placed on the upper part of the face, and the left side placed on the upper part of the face is By pulling upwards, it is possible to create a lifting effect.

The first coating layer 20 is a coating layer coated on the outside of the yarn 10 , and may be coated after the protrusions 11 are formed on the yarn 10 . Specifically, the first coating layer 20 may be provided so as to completely surround the outer surface of the yarn 10 on which the protrusions 11 are formed.

In this case, the first coating layer 20 may be formed on the surface of the yarn 10 through a dip coating method. The dip coating method is a type of coating method, and refers to a method of coating the surface of a material to be coated by immersing the material to be coated (the yarn 10 in the present invention) in a coating solution. In this embodiment, it can be used as a coating solution by dissolving the coating material provided in powder form.

As another example, the first coating layer 20 may be formed on the surface of the yarn 10 through a spray coating method or an ultrasonic coating method.

A more detailed description of the method of forming the first coating layer 20 on the surface of the yarn 10 will be described later.

The first coating layer 20 may be formed of a second biodegradable material. For example, the second biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL), poly-L-lactide (Poly-L-lactide, PLLA) ) may be any one of. In this case, the second biodegradable material may be a biodegradable material different from the first biodegradable material. For example, when the first biodegradable material is provided as poly-ε-caprolactone (PCL), the second biodegradable material may be provided as poly-L-lactide (PLLA). However, the second biodegradable material constituting the first coating layer 20 is not limited thereto, and the first coating layer 20 improves the tensile force of the yarn 10 or reduces the rate at which the yarn 10 is decomposed. It can be provided in a variety of biodegradable materials that can slow it down.

The thickness ratio of the first coating layer 20 and the yarn 10 may be 1:3000 to 1:3. When the first coating layer 20 is formed too thin, the effect of improving the tensile force of the yarn 10 may be reduced As a result, the lifting effect may be reduced. The first coating layer 20 improves the tensile force of the medical thread 1 while maintaining the needle-like shape of the protrusion 11 and provides a thickness ratio of 1:3000 to 1:3 with the yarn and the medical thread (1) It has the advantage of slowing down the decomposition rate of

3 is a cross-sectional view of a cross-section taken along line B-B according to the type of the first coating layer of FIG. 1 observed under a microscope. Specifically, the left diagram of FIG. 3 is a cross-sectional view of the medical seal 1 when the first coating layer 20 is provided with poly-ε-caprolactone (PCL), and the right diagram of FIG. 3 is the first coating layer 20 It is a cross-sectional view of the medical thread 1 in the case where this poly-L-lactide (PLLA) was provided.

Referring to FIG. 3 , the first coating layer 20 formed of poly-ε-caprolactone (PCL) is higher than the first coating layer 20 formed of poly-L-lactide (PLLA). It can be seen that the coating can be relatively thick.

4 is a graph showing the test results of measuring the maximum tensile stress over time according to the presence or absence of the first coating layer and the type of the first coating layer of the medical thread of FIG. 1 .

In the test of FIG. 4 , an uncoated yarn, a yarn 10 coated with poly-ε-caprolactone (PCL), and a yarn coated with poly-L-lactide (PLLA) (10) was supported in each supporting solution, and the maximum tensile stress of each yarn 10 was tested for each supporting period. At this time, the supporting solution was 37° C. 1x PBS, and each yarn 10 was supported in this supporting solution for up to 90 days, and the maximum tensile stress was measured every 30 days.

Referring to FIG. 4 , the yarn 10 having the first coating layer 20 formed of poly-ε-caprolactone (PCL) and poly-L-lactide (PLLA) is not coated. It can be seen that the reduction rate of the tensile stress is relatively small compared to that of the yarn.

That is, as can be seen from the graph of FIG. 4 , the medical thread 1 is formed with the first coating layer 20 formed of the second biodegradable material, thereby slowing the rate of decomposition in the skin. In addition, it is possible to slow the rate at which the tensile stress is reduced due to the first coating layer 20 , so that the lifting effect can be sustained for a long time.

Hereinafter, a medical seal 1 ′ according to another embodiment of the present invention will be described with reference to FIG. 5 . However, since the embodiment of Fig. 5 is different in that the second coating layer 30 is further provided compared to the embodiment of Figs. The description of the embodiment and reference numerals are used.

5 is a cross-sectional view of a medical seal according to another embodiment of the present invention.

Referring to FIG. 5 , the medical thread 1 ′ may further include a second coating layer 30 provided between the yarn 10 and the first coating layer 20 .

The second coating layer 30 is a coating layer for improving the functionality and antibacterial properties of the yarn 10 , and may be provided between the yarn 10 and the first coating layer 20 . In this case, the second coating layer 30 may be provided with an anti-inflammatory material. Here, the anti-inflammatory substance means a substance having a property of preventing or alleviating inflammation. Specifically, the second coating layer 30 may be provided with any one of calcium stearate, PLA, PGA, PLA/PGA copolymer, a hydrophobic biodegradable polymer material including PCL, dexamethasone, and gentamicin. However, the material constituting the second coating layer 30 is not limited thereto.

The medical thread 1 is to be inserted into the skin tissue, and its antibacterial properties are important. By coating the surface of the yarn 10 with a separate second coating layer 30, there is an advantage that antibacterial properties can be improved.

Hereinafter, a method of manufacturing the medical seal 1 having the same configuration as in FIGS. 1 to 4 will be described with reference to FIG. 6 . However, in the medical thread manufacturing method, the same reference numerals are used for the same or similar configuration to the configuration described in the medical thread 1 according to the embodiment of the present invention salpin above, and the overlapping description is simplified or omitted. do.

6 is a flowchart illustrating a method for manufacturing a medical thread according to an embodiment of the present invention.

Referring to FIG. 6 , the method for manufacturing a medical thread according to an embodiment of the present invention includes the steps of preparing the yarn 10 ( S1 ), and forming the protrusion 11 on the yarn 10 ( S2 ) and , forming the first coating layer 20 on the surface of the yarn 10 (S3), drying the first coating layer 20 (S4), and removing the toxicity of the medical thread (1) (S5) ) may be included.

In this embodiment, the yarn 10 used for the medical thread 1 may be provided as a first biodegradable material. For example, the first biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL), poly-L-lactide (Poly-L-lactide, PLLA) ) may be any one of. Since the yarn 10 is formed of the first biodegradable material, it may be gradually lost over time by the action with the body.

In addition, by cutting the outer surface of the yarn 10, a plurality of projections 11 may be formed on the yarn 10 (S2). Specifically, by obliquely cutting the outer surface of the yarn 10 , the protrusion 11 may be formed on the outer surface of the yarn 10 . For example, by using a cutter, the protrusion 11 may be formed by cutting from the surface of the yarn 10 to the center line of the yarn 10 at a predetermined angle.

The protrusion 11 allows the medical thread 1 to function to pull the skin or muscle tissue by being caught on the surrounding skin or muscle tissue when the medical thread 1 is inserted into the body. The medical thread (1) can be used in a lifting procedure that tightens the skin by forming such a protrusion (11).

In this case, the protrusion 11 may be formed in a needle-like shape with a sharp tip. Since the protrusion 11 is formed in a pointed shape, there is an advantage in that the skin tissue can be easily caught on the protrusion 11 . Accordingly, the lifting effect can be generated more effectively.

After the protrusions 11 are formed on the yarn 10 , the outer surface of the yarn 10 may be coated with the first coating layer 20 ( S3 ). The first coating layer 20 may be formed of a second biodegradable material. At this time, the second biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) It can be any one. However, the second biodegradable material constituting the first coating layer 20 is not limited thereto, and the first coating layer 20 improves the tensile force of the yarn 10 or reduces the rate at which the yarn 10 is decomposed. It can be provided in a variety of biodegradable materials that can slow it down.

The coating of the first coating layer 20 is made after the formation of the protrusions 11 , and the first coating layer 20 may be coated on the entire outer surface of the yarn 10 on which the protrusions 11 are formed. Accordingly, the tensile force of the medical thread 1 can be further improved, and the decomposition rate of the medical thread 1 can be slowed to increase the duration of the lifting effect.

In this case, the first coating layer 20 may be formed on the surface of the yarn 10 through a dip coating method. The dip coating method is a type of coating method, and refers to a method of coating the surface of a material to be coated by immersing the material to be coated (the yarn 10 in the present invention) in a coating solution.

Specifically, the first coating layer 20 may be formed to completely cover the outer surface of the yarn 10 by supporting the yarn 10 having the projection 11 in the coating solution formed of the second biodegradable material. have. At this time, the coating solution is Tetrahydrofuran (THF), Dimethylacetamide (DMAc), N-methyl-2-pyrrolidone (NMP), Hexafluorisopropanol (HFIP), Butylated hydroxytoluene (BHT), Dimethylformamide (DMF), Dimethylsulfoxide (DMSO), 1,2 ,4-Trichlorobenzene (TCB), Chloroform, Sodium trifluoroacetate (NaTFA), Triethylamine (TEA) in any one or a mixture of these, the second biodegradable material is dissolved in a concentration of 0.01 to 10wt% It can be prepared. Since the coating solution is formed of the same material and concentration as above, the first coating layer 20 can be uniformly coated on the surface of the yarn 10, and the thickness ratio of the first coating layer 20 and the yarn 10 is It allows the formation of 1:3000 to 1:3.

In addition, by forming the first coating layer 20 using the dip coating method, the first coating layer 20 can be uniformly coated on the surface of the yarn 10, and the loss rate of raw materials can be reduced. In addition, by using the dip coating method, the construction of mass production equipment can be easily made. In addition, since the dip coating method can be made at low cost, it is possible to reduce the cost of the medical thread 1 .

In this embodiment, it has been described that the first coating layer 20 is coated on the outer surface of the yarn 10 using a dip coating method, but the method of forming the first coating layer 20 is not limited thereto, and the known Various coating methods can be used. For example, the first coating layer 20 may be formed on the surface of the yarn 10 through a spray coating method or an ultrasonic coating method. Here, the spray coating method refers to a method of coating by spraying a coating solution onto a material to be coated (in the present invention, the yarn 10) using a device such as a sprayer. In addition, here, the ultrasonic coating method refers to a method of coating by spraying a coating solution onto a material to be coated by vibration by ultrasonic waves.

The medical thread manufacturing method may include drying the first coating layer 20 (S4). For example, the first coating layer 20 may be dried through freeze-drying. As another example, the first coating layer 20 may be dried by hot air having a temperature of 30°C to 100°C or vacuum drying at the same temperature. In this case, the drying time is preferably at least 10 minutes or longer.

In addition, it may include an additional toxicity removal step (S5). Specifically, the toxicity of the medical seal 1 may be removed through the cleaning solution. The cleaning solution for detoxification may be provided as any one of deionized water, methanol, (MeOH), ethanol (EtOH), and isopropyl alcohol (IPA) or a mixture thereof. However, the material constituting the washing solution is not limited thereto. In addition, when the toxicity removal step (S5) is performed, a separate drying process for drying the washing solution may be additionally performed.

Hereinafter, a method of manufacturing a medical seal 1 ′ having the same configuration as that of FIG. 5 will be described with reference to FIG. 7 . However, in the medical thread manufacturing method, there is a difference in that it further includes the step (S6) of forming the second coating layer 30 compared to the medical thread manufacturing method of FIG. Duplicate descriptions of the same steps will be simplified or omitted.

Referring to FIG. 5 , the method of manufacturing the medical thread 1 ′ may further include forming a second coating layer 30 on the surface of the yarn 10 ( S6 ).

The second coating layer 30 is a coating layer for improving the functionality and antibacterial properties of the yarn 10 , and the second coating layer 30 may be provided with an anti-inflammatory material. Here, the anti-inflammatory substance means a substance having a property of preventing or alleviating inflammation. Specifically, the anti-inflammatory material provided as a material of the second coating layer 30 is a hydrophobic biodegradable polymer material including calcium stearate, PLA, PGA, PLA/PGA copolymer, PCL, dexamethasone, and genta. It may be any one of mycin. However, the material constituting the second coating layer 30 is not limited thereto.

Since the second coating layer 30 is provided with an anti-inflammatory material that resists inflammation, it is possible to prevent side effects such as skin inflammation due to the medical thread 1 after the lifting procedure. In addition, even if side effects such as skin inflammation occur after the lifting procedure, the inflammation can be easily alleviated by alleviating it.

In this case, the step (S6) of forming the second coating layer 30 may be performed between the step (S1) of preparing the yarn (10) and the step (S2) of forming the projections 11 on the yarn (10). When the step (S4) of forming the second coating layer 30 is performed before the step (S2) of forming the protrusion 11, the second coating layer 30 is not formed on the inside of the protrusion 11, but the protrusion ( 11) can be formed only on the outside.

Specifically, the step (S6) of forming the second coating layer 30 may be performed before the step (S2) of forming the protrusion 11 on the yarn 10, and accordingly, the inner side of the protrusion 11 is the second It may not be coated with the coating layer 30 .

Since the yarn 10 is coated with a separate second coating layer 30 , there is an advantage that antibacterial properties can be improved.

Above, the medical thread and the manufacturing method according to the embodiment of the present invention have been described as specific embodiments, but this is only an example, and the present invention is not limited thereto, and has the widest scope according to the basic idea disclosed in the present specification. should be interpreted as A person skilled in the art may implement a pattern of a shape not specified by combining or substituting the disclosed embodiments, but this also does not depart from the scope of the present invention. In addition, those skilled in the art can easily change or modify the disclosed embodiments based on the present specification, and it is clear that such changes or modifications also fall within the scope of the present invention.

1, 1': medical thread
10: yarn
11: Turn
20: first coating layer
30: second coating layer

Claims (18)

A yarn formed of a first biodegradable material, formed by a method of cutting the outer surface and including a plurality of protrusions protruding outward on the surface; and
a first coating layer formed of a second biodegradable material different from the first biodegradable material, and coated after the protrusions are formed on the yarn to completely surround the outer surface of the yarn; and
It is provided with an anti-inflammatory material, and comprises a second coating layer formed between the yarn and the first coating layer,
The second coating layer is coated before the projection is formed on the yarn and is formed on the outside of the projection, not on the inside of the projection,
The projection is a medical thread provided as a bed. According to claim 1,
The first biodegradable material is any one of polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) One medical thread. According to claim 1,
The second biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) any One medical thread. According to claim 1,
The first coating layer and the thickness ratio of the yarn is 1:3000 to 1:3 medical thread. delete According to claim 1,
The anti-inflammatory substance is any one of dexamethasone and gentamicin for medical use. delete According to claim 1,
A plurality of the projections are medical thread in which the protrusion direction with respect to the longitudinal direction of the yarn is the same. delete According to claim 1,
The forming angle of the projection with respect to the longitudinal direction of the yarn is 30 ° to 60 ° medical thread. A method for manufacturing a medical thread, comprising:
Preparing a yarn formed of a first biodegradable material;
forming a plurality of needle-like protrusions on the yarn by cutting the outer surface of the yarn;
Forming a second coating layer provided with an anti-inflammatory material between the yarn and the first coating layer before the step of forming a plurality of needle-like projections on the yarn; and
Comprising the step of forming the first coating layer formed of a second biodegradable material different from the first biodegradable material after the step of forming a plurality of needle-like projections on the yarn,
The second coating layer is not formed on the inner side of the protrusion, but the medical thread manufacturing method is formed on the outside of the protrusion. 12. The method of claim 11,
The first biodegradable material is any one of polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) One method for manufacturing a medical thread. 12. The method of claim 11,
The second biodegradable material is polydioxanone (Polydioxanone, PDO), poly-ε-caprolactone (Poly-ε-caprolactone, PCL) and poly-L-lactide (Poly-L-lactide, PLLA) any One method for manufacturing a medical thread. 12. The method of claim 11,
The step of forming the first coating layer is a method for manufacturing a medical thread through any one of a dip coating method, a spray coating method, and an ultrasonic coating method. delete 12. The method of claim 11,
The method for manufacturing a medical thread wherein the anti-inflammatory substance is any one of dexamethasone and gentamicin. 12. The method of claim 11,
The method of manufacturing a medical thread further comprising the step of drying the first coating layer. 12. The method of claim 11,
The method of manufacturing a medical thread further comprising the step of removing the toxicity of the medical thread.

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