CN108434247A - Treat dermopathic drug and preparation method thereof - Google Patents

Treat dermopathic drug and preparation method thereof Download PDF

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Publication number
CN108434247A
CN108434247A CN201810429371.XA CN201810429371A CN108434247A CN 108434247 A CN108434247 A CN 108434247A CN 201810429371 A CN201810429371 A CN 201810429371A CN 108434247 A CN108434247 A CN 108434247A
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China
Prior art keywords
parts
composition
drug
preparation
capsule
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Pending
Application number
CN201810429371.XA
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Chinese (zh)
Inventor
杨明
杨成义
杨岩
杨健
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Guanghe County Sheng And Hospital Of Traditional Chinese Medicine
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Guanghe County Sheng And Hospital Of Traditional Chinese Medicine
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Priority to CN201810429371.XA priority Critical patent/CN108434247A/en
Publication of CN108434247A publication Critical patent/CN108434247A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13Coniferophyta (gymnosperms)
    • A61K36/15Pinaceae (Pine family), e.g. pine or cedar
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/12Keratolytics, e.g. wart or anti-corn preparations

Abstract

Dermopathic drug and preparation method thereof is treated the invention discloses a kind of, the drug includes the first composition and the second composition, and the first composition includes:In terms of mass fraction, the dosage form of 0.5 2 parts of Antrodia camphoratas, 0.5 2 parts of cordyceps sinensis, 15 parts of kuh-sengs, 26 parts of root barks of Chinese wolf-berry, 26 parts of fruit of summer cypress, 15 portions of Cortex Phellodendris, 26 parts of Golden Larch Barks, the first composition is capsule;Second composition includes:In terms of mass fraction, the dosage form of 38 parts of honeycomb, 0.5 2 parts of Moschus, 15 parts of calamines, 15 parts of almonds, the second composition is lotion.The present invention is prepared using pure Chinese medicine, side effect very little, both symptoms and root causes, can be used for treating a variety of refractory skins, and therapeutic effect protrudes, and clinical application has fine curative effect.

Description

Treat dermopathic drug and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology field more particularly to a kind for the treatment of dermopathic drug and preparation method thereof.
Background technology
Skin is the first line of defence that human body resists extraneous various stimulations, and healthy skin has extremely each organ of human body Important protective effect.In recent years, since environmental pollution exacerbation, a large amount of uses of food additives and people are unsound Living habit etc. causes dermopathic illness rate to increase, and common skin disease has acne, acne, psoriasis, flat wart, intractable Lichen, ichthyosis, melanoderma, erythroderma, various lupus erythematosus, leucoderma etc., these skin diseases belong to refractory skin, Treatment difficulty is larger, and treatment cycle is long, and certain psychological pressure is caused to patient, influences the quality of life of patient, also, existing The state of an illness that is directed to of the dermopathic drug for the treatment of it is relatively simple, specific aim is stronger, the effect of generation for different skin diseases Also different, it is effective in cure to some skin diseases, other may not acted on completely, cannot be satisfied people and treat multiple dermatosis Demand.
Invention content
Dermopathic drug and preparation method thereof is treated the purpose of the present invention is to provide a kind of, it is intended to solve above-mentioned background The difficulty of existing treatment refractory skin is larger in technology, and treatment cycle is long, and treats the drug needle of refractory skin It is stronger to property, it is relatively simple to the skin disease treated, it cannot be satisfied the problem of people treat multiple dermatosis demand.
The invention is realized in this way a kind for the treatment of dermopathic drug, including the first composition and second is combined into Point, first composition includes:In terms of mass fraction, 0.5-2 parts of Antrodia camphoratas, 0.5-2 parts of cordyceps sinensis, 1-5 parts of kuh-sengs, The dosage form of the 2-6 parts of root barks of Chinese wolf-berry, the 2-6 parts of fruit of summer cypress, 1-5 portions of Cortex Phellodendris, 2-6 parts of Golden Larch Barks, first composition is capsule; Second composition includes:In terms of mass fraction, 3-8 parts of honeycomb, 0.5-2 parts of Moschus, 1-5 parts of calamines, 1-5 portions of apricots The dosage form of benevolence, second composition is lotion.
Preferably, first composition includes:In terms of mass fraction, 1 part of Antrodia camphorata, 1 part of cordyceps sinensis, 3 parts of hardships Ginseng, 4 parts of root barks of Chinese wolf-berry, 4 parts of fruit of summer cypress, 3 portions of Cortex Phellodendris, 4 parts of Golden Larch Barks.
Preferably, second composition includes:In terms of mass fraction, 5 parts of honeycomb, 1 part of Moschus, 3 parts of calamines, 3 Part almond.
Invention further provides a kind of preparation methods for treating dermopathic drug, include the preparation side of capsule Method specifically includes following steps:
(1) it is crushed after weighing Antrodia camphorata, cordyceps sinensis, kuh-seng, the root bark of Chinese wolf-berry, the fruit of summer cypress, Cortex Phellodendri, Golden Larch Bark respectively;
(2) medicinal material after crushing is uniformly mixed and forms mixed powder;
(3) mixed powder is packaged into capsule, every capsule inner packing 1.2g mixed powder.
Invention further provides a kind of preparation methods for treating dermopathic drug, include the preparation side of lotion Method specifically includes following steps:
(1) it is mixed after weighing honeycomb, Moschus, calamine, almond respectively, adds water immersion 24 hours;
(2) drug small fire is tortured 1 hour after impregnating, and is filtered, cooling, and taking liquid is for use;
(3) liquid is packaged into bag, every bag is 100mL, sets shady place preservation, and storage temperature is 2-8 DEG C.
Compared with the prior art the shortcomings that and deficiency, the invention has the advantages that:Present invention treatment is dermopathic Drug is prepared using pure Chinese medicine, and side effect very little, both symptoms and root causes can be used for treating a variety of refractory skins, such as acne, silver Consider disease, flat wart, intractable lichen, ichthyosis, melanoderma, erythroderma, lupus erythematosus, leucoderma etc. to be worth doing, therapeutic effect protrudes, faces Bed application has fine curative effect.
Specific implementation mode
In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment, to this Invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, not For limiting the present invention.
Embodiment 1
It is a kind of to treat dermopathic drug, including the first composition and the second composition, first composition Including:In terms of mass fraction, 0.5-2 parts of Antrodia camphoratas, 0.5-2 parts of cordyceps sinensis, 1-5 parts of kuh-sengs, the 2-6 parts of root barks of Chinese wolf-berry, 2-6 parts of ground The dosage form of skin, 1-5 portions of Cortex Phellodendris, 2-6 parts of Golden Larch Barks, first composition is capsule.
Embodiment 2
It is a kind of to treat dermopathic drug, including the first composition and the second composition, first composition Including:In terms of mass fraction, 1 part of Antrodia camphorata, 1 part of cordyceps sinensis, 3 parts of kuh-sengs, 4 parts of root barks of Chinese wolf-berry, 4 parts of fruit of summer cypress, 3 parts of Cortex Phellodendris, 4 The dosage form of part Golden Larch Bark, first composition is capsule.
Embodiment 3
It is a kind of to treat dermopathic drug, including the first composition and the second composition, second composition Including:In terms of mass fraction, 3-8 parts of honeycomb, 0.5-2 parts of Moschus, 1-5 parts of calamines, 1-5 parts of almonds, described second is combined into The dosage form divided is lotion.
Embodiment 4
It is a kind of to treat dermopathic drug, including the first composition and the second composition, second composition Including:In terms of mass fraction, 5 parts of honeycomb, 1 part of Moschus, 3 parts of calamines, 3 parts of almonds, the dosage form of second composition is Lotion.
Embodiment 5
The preparation method of capsule of the present invention, specifically includes following steps:
(1) it is crushed after weighing Antrodia camphorata, cordyceps sinensis, kuh-seng, the root bark of Chinese wolf-berry, the fruit of summer cypress, Cortex Phellodendri, Golden Larch Bark respectively;
(2) medicinal material after crushing is uniformly mixed and forms mixed powder;
(3) mixed powder is packaged into capsule, every capsule inner packing 1.2g mixed powder.
Embodiment 6
The preparation method of lotion of the present invention, specifically includes following steps:
(1) it is mixed after weighing honeycomb, Moschus, calamine, almond respectively, adds water immersion 24 hours;
(2) drug small fire is tortured 1 hour after impregnating, and is filtered, cooling, and taking liquid is for use;
(3) liquid is packaged into bag, every bag is 100mL, sets shady place preservation, and storage temperature is 2-8 DEG C.
The application method of drug of the present invention is:
Capsule and lotion are used cooperatively, and wherein capsule is oral medicine, and lotion is externally applied drug, capsule one time 5 Grain (every contain 1.2g mixed powders), 3 times a day, 10-30 days as a treatment course, lotion 3-5 time on the one, disinfection when use Cotton swab dips appropriate lotion and is uniformly applied to skin affected part, and 10-30 days as a treatment course, avoid pungent food stimulation food during medication Object.
According to clinical verification by above-described embodiment, 20 people of psoriatic is tested, 10 people of experiment ringworm of the body patient tests leucoderma 20 people of patient, patient takes the capsule in embodiment 2 in experiment, and patient skin affected part is cleaned with the lotion in embodiment 4.
Now it is illustrated below:Horse XX, man, 63 years old, Gansu Guanghe people suffered from psoriasis, Keratoderma disease, trunk and four Limb rubefaction, furfur, is formed a scab more than 10 years at itch, and multi-party treatment has no resolution.The capsule in embodiment 2 is taken, skin affected part is used Lotion cleaning in embodiment 4, after treating 1 month, patient's four limbs are fully recovered without red and swollen, itch, epidermis without falling off.
Horse XX, female, 10 years old, Gansu Guanghe people suffered from systemic multiple ringworm of the body, takes the capsule in embodiment 2, skin Affected part is cleaned with the lotion in embodiment 4, is treated through 24 days, and the double upper arm of patient, trunk and double lower limb maculopapule color are apparent Subside, patch is obviously reduced, and no itch pain, constitutional symptom is obviously improved, is almost recovered.
Horse XX, man, 68 years old, Gansu Guanghe people suffered from systemic leucoderma 15 years, once multiple multi-treatment, does not play treatment Effect, takes the capsule in embodiment 2, and skin affected part is cleaned with the lotion in embodiment 4, after treating 1 month, patient's leucoderma Wind color is clearly better, and currently treats.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement etc., should all be included in the protection scope of the present invention made by within refreshing and principle.

Claims (5)

1. a kind for the treatment of dermopathic drug, which is characterized in that the drug includes the first composition and the second composition, First composition includes:In terms of mass fraction, 0.5-2 parts of Antrodia camphoratas, 0.5-2 parts of cordyceps sinensis, 1-5 parts of kuh-sengs, 2-6 The dosage form of part root bark of Chinese wolf-berry, the 2-6 parts of fruit of summer cypress, 1-5 portions of Cortex Phellodendris, 2-6 parts of Golden Larch Barks, first composition is capsule;Institute Stating the second composition includes:In terms of mass fraction, 3-8 parts of honeycomb, 0.5-2 parts of Moschus, 1-5 parts of calamines, 1-5 parts of almonds, The dosage form of second composition is lotion.
2. the dermopathic drug for the treatment of according to claim 1, which is characterized in that first composition includes:With Mass fraction meter, 1 part of Antrodia camphorata, 1 part of cordyceps sinensis, 3 parts of kuh-sengs, 4 parts of root barks of Chinese wolf-berry, 4 parts of fruit of summer cypress, 3 portions of Cortex Phellodendris, 4 parts of native chaste trees Skin.
3. the dermopathic drug for the treatment of according to claim 1, which is characterized in that second composition includes:With Mass fraction meter, 5 parts of honeycomb, 1 part of Moschus, 3 parts of calamines, 3 parts of almonds.
4. a kind of preparation method for treating dermopathic drug as claimed in claim 1 or 2, which is characterized in that the preparation Method includes the preparation method of capsule, specifically includes following steps:
(1) it is crushed after weighing Antrodia camphorata, cordyceps sinensis, kuh-seng, the root bark of Chinese wolf-berry, the fruit of summer cypress, Cortex Phellodendri, Golden Larch Bark respectively;
(2) medicinal material after crushing is uniformly mixed and forms mixed powder;
(3) mixed powder is packaged into capsule, every capsule inner packing 1.2g mixed powder.
5. a kind of preparation method of dermopathic drug for the treatment of as described in claim 1 or 3, which is characterized in that the preparation Method includes the preparation method of lotion, specifically includes following steps:
(1) it is mixed after weighing honeycomb, Moschus, calamine, almond respectively, adds water immersion 24 hours;
(2) drug small fire is tortured 1 hour after impregnating, and is filtered, cooling, and taking liquid is for use;
(3) liquid is packaged into bag, every bag is 100mL, sets shady place preservation, and storage temperature is 2-8 DEG C.
CN201810429371.XA 2018-05-08 2018-05-08 Treat dermopathic drug and preparation method thereof Pending CN108434247A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102199082B1 (en) * 2019-07-11 2021-01-06 인하대학교 산학협력단 Pharmaceutical composition for preventing or treating vitiligo or canities comprising extract of Prunus armeniaca as an active ingredient

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104056218A (en) * 2014-06-09 2014-09-24 韩龙龙 Medicine for treating skin diseases and preparation method of medicine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104056218A (en) * 2014-06-09 2014-09-24 韩龙龙 Medicine for treating skin diseases and preparation method of medicine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102199082B1 (en) * 2019-07-11 2021-01-06 인하대학교 산학협력단 Pharmaceutical composition for preventing or treating vitiligo or canities comprising extract of Prunus armeniaca as an active ingredient

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Application publication date: 20180824