WO2012141381A1

WO2012141381A1 - Functional thread for a subcutaneous medical procedure, and device for performing a medical procedure including same

Info

Publication number: WO2012141381A1
Application number: PCT/KR2011/005000
Authority: WO
Inventors: 김병건; 이해우
Original assignee: Kim Byung Gun; Lee Hae Woo
Priority date: 2011-04-14
Filing date: 2011-07-08
Publication date: 2012-10-18

Abstract

The present invention relates to a thread for a subcutaneous medical procedure, including a biodegradable thread for a medical procedure, and a functional substance coated over the thread or forming the thread. According to the above configuration, skin regeneration can be expedited by increasing the production of collagen and elastin through stimulating subcutaneous tissue by means of inserting same between the dermis and the subcutaneous layer, and simultaneously, by treating the thread by coating same with a functional material or a drug, better results for skin regeneration can be achieved, or the functional thread and device can be used as a drug delivery system (DDS).

Description

Functional surgical room for skin insertion, and a surgical device comprising the same

The present invention relates to a surgical thread and a surgical device including the same, and more particularly, to stimulate the subcutaneous tissue by inserting it between the dermis and subcutaneous fat layer to increase the production of collagen and elastin to promote skin regeneration, and at the same time functional It is to provide a treatment chamber and a treatment apparatus including the same, which is also used as a drug delivery system (DDS) for more enhanced effect of skin regeneration by coating a substance or drug on the seal.

Skin is the largest organ in the human body. The skin protects the body from environmental toxins and microorganisms and prevents water from evaporating. In general, the human skin consists of two layers of tissue. One is the keratinized and layered epidermis, and the other is the collagen-rich dermal connective tissue basal layer that provides support and nutrition.

Skin aging is known to be caused by cell variability, free radical radicals, accumulation of toxic substances, and alteration of skin gap constituent proteins. Despite numerous studies on the exact cause, each major cause wrinkles to the skin by any mechanism. It is not clear whether it is formed, and the result of aging is caused by wrinkles, decreased elasticity and spot formation of the skin. In addition, the ability of collagen to be closely related to healthy skin decreases and abnormal stringency of these collagen fibers increases, thereby significantly reducing skin elasticity, and glycosaminoglycol, a type of hyaluronic acid and glycoprotein, which is responsible for skin moisturizing. It is reported that the yield of cells is significantly reduced.

To date, numerous substances have been used to suppress skin aging, and vitamin C (Vitamin C), SOD, α-tocopherol (Vitamin E), and β-carotene (WV), which have been used for a long time, have been used for anti-wrinkle treatment due to antioxidant effects. β-carotene), etc., are known to reduce skin aging through the antioxidant effect to improve wrinkles and skin elasticity.

Recently, a lot of natural materials have been noticed and used in the flow of herbal cosmetics, but it is known that these methods have not been satisfactory in a short time with regard to skin regeneration and wrinkle removal effects.

In addition, until now, therapeutic drugs such as insulin have been administered by a method by intraperitoneal injection or light administration. However, since these drugs are usually released all at once in the human body, the drug effect is not continuously achieved. Therefore, many studies have been conducted on sustained-release formulations having sustained-release properties. Usually, they are mixed with a component such as a binder and a biodegradable polymer to form an envelope. One formulation is mostly.

The present invention has been made to solve the problems of the prior art as described above, its purpose is to stimulate the subcutaneous tissue by inserting between the dermis and subcutaneous fat layer to increase the production of collagen and elastin to promote skin regeneration The present invention provides a biodegradable treatment chamber for skin insertion.

Another object of the present invention is to provide a seal for inserting the skin, which is used as a drug delivery system (DDS) for further enhancing the effect of skin regeneration, by containing functional substances in the yarn, and exhibiting various functionalities. Is in.

Another object of the present invention is to stimulate the subcutaneous tissue by inserting between the dermal layer and the subcutaneous fat layer to increase the production of collagen and elastin to promote skin regeneration, and at the same time to regenerate the skin by coating a functional material or drug on the thread It is to provide a surgical device comprising a chamber for the treatment is also used as a more enhanced effect of the drug delivery system (DDS: Drug Delivery System).

The technical problem of the present invention as described above is achieved by the following means.

(1) Skin insertion procedure consisting of biodegradable thread.

(2) biodegradable yarns; And a functional material coated on the biodegradable yarn or constituting a biodegradable yarn.

(3) a surgical insert for skin insertion comprising a biodegradable yarn or a functional material coated on or constituting the biodegradable yarn; And a surgical needle having one end of the surgical chamber accommodated therein and having a hollow portion in which the thread can be separated upon insertion into the skin.

(4) the method of paragraph 3,

A device for skin insertion, characterized in that the handle is formed integrally with the needle at the end of the needle.

(5) The method according to 2,

Said functional substance is a skin moisturizing agent, amino acids, antioxidants, antioxidant enzymes, drugs, herbal extracts, mushroom extract for the skin insertion process, characterized in that at least one selected from.

(6) the method of paragraph 5,

The drug is alopecia, magnesium salicylate, salsalate, acetaminophen, diclofenac, eto, anti-hair loss, erectile dysfunction, insulin, LHRH, collagen, ceramide, elastin, calcium hydroxy apatite, nonsteroidal analgesic Dolac, Phenoprofen, Flubiprofen, Ibuprofen, Indomethacin, Ketoprofen, Meclofenamate, Meloxycham, Nabumethone, Naproxen, Pyroxycam, Suldinak, Tolmetin, Zatoprofen, Celecoxib, valdecoxib, and rofecoxib, cortisol, prednisone, prednisolone, methylprednisolone, prdrocortisol, cortisone, triamcinolone, betamethasone and dexamethasone as steroids, codeine, morphine sulfate, hydromorphine HCl , Morphine HCl, Fetidine HCl, Codeine Phosphate, Fentanyl, Oxycodone HCl, and Tramadol, Male Hormone, Female Hormone, Sex At least one selected from intestinal hormones and thyroid hormones, the procedure for skin insertion.

(7) A drug carrier for skin insertion, characterized in that the drug is coated in the procedure room of (1).

According to the present invention, by inserting between the dermal layer and the subcutaneous fat layer, the subcutaneous tissue is stimulated to increase the production of collagen and elastin to promote skin regeneration, and at the same time, the coating of a functional substance or drug on the yarn provides more It provides an enhanced effect or an effect that can also be used as a drug delivery system (DDS).

1 is a cross-sectional view of the skin insertion chamber according to the present invention.

2 is a configuration example of a surgical apparatus according to a first embodiment of the present invention.

3 is a configuration example of a surgical apparatus according to a second embodiment of the present invention.

Figure 4 is an exemplary view showing the position where the treatment device is inserted according to the present invention.

5 is a photograph before and after the procedure according to the present invention [A: before the procedure, B: after the procedure]

The present invention includes a procedure for inserting the skin consisting of a biodegradable yarn.

The present invention also provides a biodegradable seal; And it provides a surgical insertion chamber comprising a functional material coated on the biodegradable yarn or constituting the yarn.

In another aspect, the present invention is a bio-degradable yarn, or a surgical insertion chamber comprising a functional material coated on the biodegradable yarn or constituting the biodegradable yarn; One end of the treatment chamber is accommodated, and provides a surgical insertion device comprising a surgical needle having a hollow that can be separated when inserted into the skin.

Hereinafter, the content of the present invention will be described in detail.

The skin insertion procedure according to the present invention shown in Figure 1 is excellent skin regeneration effect, and when a functional material is reinforced there may be continuously exerted a predetermined function without the need for periodic injection or oral administration separately It functions as a kind of drug delivery system.

More preferred embodiment in the present invention, the skin insertion chamber 100 is a biodegradable seal 10; And a functional material 11 coated on the biodegradable yarn or constituting the biodegradable yarn.

In the present invention, the procedure room 10 may be used in any material that can be used as a surgical suture without being decomposed in vivo and at the same time harmless to the human body. Examples of such sutures include natural fibers such as cat gut, silk, chitulose fibers, polyglycolide, polylactide, polyglycolide-lactide copolymers, polycaprolactam and copolymers thereof, Absorption decomposable sutures, such as a poly (p-dioxane) and its copolymer, etc. are mentioned.

In the present invention, the surface of these yarns may be coated with a functional material, or a polymer synthesized by adding a functional material as a monomer in the process of synthesizing a yarn (for example, a surgical suture) may be used. . In some cases, it is also possible to manufacture such a suture using the functional material itself as a raw material.

In the present invention, the functional substance may be selected from skin moisturizers, amino acids, antioxidants, antioxidant enzymes, drugs, herbal extracts, and mushroom extracts.

As an example of the skin moisturizer is hyaluronic acid that can be administered subcutaneously.

Various amino acids include histidine, isoleucine, leucine, lysine, methionine, threonine, valine, alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamic acid, glutamine, glycine, ornithine, proline, serine, taurine, tyrosine Etc. can be mentioned.

In the above antioxidants, polyphenols, coenzyme Q10, vitamin C, idebenone, anthocyanin, alpha tocopherol, fiber, omega-3,6,9, phytosterol, minerals, glucosamine, celadrin, quinic acid, serotonin, norepinephrine, Beta-carotene, melatonin, carotenoids, flavonoids, iron, manganese, zinc, selenium, enacetylcysteine, catechins, lutein, sesamine, quercetin, aliin, ezif (EGF), alpha lipoic acid, theanine, resveratrol, lycopene, saponin, gin Cenosides etc. are mentioned.

Examples of the antioxidant enzymes include SOD [Super Oxide Dismutase], Catalase (Catalase), Gpx [Glutathione Peroxidase], and the like.

In the above, the drug is not particularly limited unless the drug is prohibited in principle to be administered to the skin. Examples of preferred drugs in the present invention, for example, minoxidil, finasteride, propesia and the like as various hair loss treatment agents, and various erectile dysfunction agents, for example, Viagra, Cialis, Ungdan, Sinyangdan, Decawon, Yaila, Udenafil, Zydena, and the like, in addition to sustained-release drugs such as insulin and LHRH, collagen, ceramide, elastin, calcium hydroxy apatite, nonsteroidal analgesic agents, such as aspirin, magnesium salicylate, salsalate, Acetaminophen, Diclofenac, Etodolac, Phenopropene, Flubiprofen, Ibuprofen, Indomethacin, Ketoprofen, Meclofenamate, Meloxycham, Nabumethone, Naproxen, Pyroxycam, Sullindoc , Tolmethine, zatoprofen, celecoxib, valdecoxib, and rofecoxib, cortisol, prednisone, prednisolone, methylfred as steroids At least one selected from solon, prdrocortisol, cortisone, triamcinolone, betamethasone and dexamethasone, codeine, morphine sulfate, hydromorphine HCl, morphine HCl, pettidine HCl, codeine phosphate, fentanyl, oxycodone HCl, and tramadol as narcotic analgesics Species, male hormones (such as testosterone), female hormones (such as estrogen), growth hormones, hormone preparations such as thyroid hormones, and the like. The drug may include all oral, injectable, and externally coated drugs.

The herbal extracts include various herbal, fruit and fruit extracts and their fermentation extracts. For example, yellow, iris, ginseng, persimmon, incense, ginseng, cheonmundong, licorice, raw sulfur, sujijihwang, baekryeok, creation, earth and sand, dew, loyalty, loyalty leaf, shiho, mackmundong, persimmon leaf, licorice, hazelnut, black bean , Cinnamon, wolfberry, tangerine, wasabi, green tea, dahlia, kelp, Danner, Angelica, jujube, deodeok, bellflower, acorn, Dong-a, camellia, tofu tea, round snap, wild chrysanthemum, perilla, dried, rhododendron, ginseng, plum, ume, Chinese quince, Dandelion, Mint, Barley, Peach, Loquat leaf, Mulberry leaf, Raspberry, Cornus, Apricot, Trilobite, Shovel, Ginger, Pomegranate, Pine needles, Mugwort, Agave, Mallow, Lotus, Manor, Ogalpi, Schisandra chinensis, Corn, Citron , Yulmu, creeper, bank, honeysuckle, ginseng, safflower, twig, price, rhododendron, plantain, gardenia, 칡, tenza, hanultari, persimmon, sunflower, brown rice, lake tiger, pumpkin, painting, cloud chrysanthemum, dumetu flower, Evening scale flowers, acai berry, blueberry, persimmon, new year, daebong, dried persimmon, tangerine, kumquat, heart citrus, 낑 , Durian, Strawberry, Raspberry, Lime, Rambutan, Red Globe, Lemon, Longan, Rich, Mango, Mangosteen, Plum, Melon, Yanggu Melon, Papaya Melon, Banana, Monkey Banana, Chestnut, Peach, Nectarine, Apple, Hongro Extracts such as apricots, pomegranates, watermelons, avocados, palms, oranges, grapefruits, melons, cheonhyehyang, cherries, kiwis, coconuts, tomatoes, cherry tomatoes, pineapples, papayas, grapes, green grapes, and broccoli.

In the above mushroom extracts include various mushroom extracts, mushroom mycelium culture and fermented extracts, for example chaga, shiitake mushrooms, mushrooms, ganoderma lucidum mushrooms, situation mushrooms, pine mushrooms, truffles, tung mushrooms, roe mushrooms, dried Shiitake mushroom, oyster mushroom, shiitake mushroom, sour mushroom, shiitake mushroom, mushroom mushroom, shiitake mushroom, shiitake mushroom, chestnut mushroom, leaf mushroom, eggplant mushroom, mulberry mushroom, shiitake mushroom, pine mushroom, kiwi mushroom, matsutake mushroom, shiitake mushroom Etc. can be mentioned.

Biodegradable yarns, or procedure yarns coated with functional materials on the biodegradable yarns, or biodegradable yarns prepared from polymerized polymers, are inserted between the dermal and subcutaneous fat layers to stimulate subcutaneous tissue and increase the production of collagen and elastin Play it back. At the same time, when the functional material is included, the functional material is gradually released in the skin, thereby providing an effect of gradually sustaining the effect. For example, if the functional substance is hyaluronic acid, it delivers moisture deep into the skin and provides the effect of improving moisturizing and elasticity.If minoxidil is coated as a hair loss treatment agent, if a thread is inserted into the scalp, even if it is not applied to the skin It will continue to provide hair loss treatment. In addition, in the case of drugs such as insulin, by simply coating the seal and inserting it into the skin, insulin is gradually supplied to blood vessels, thereby providing continuous diabetes treatment effect. In this case, the skin insertion chamber according to the present invention will function as a drug delivery system (DDS) that has not been reported previously. In particular, the present invention can be used more preferably for drugs that need to be released slowly, such as luteinizing hormone releasing hormone (LHRH) in addition to insulin.

Hereinafter, the manufacturing process of the skin insertion chamber according to the present invention will be described in detail. Hereinafter, the procedure room will be described using a suture as an example.

First, in order to coat the functional material on the suture, the suture prepared in advance is wound on a cylindrical bobbin or drum, attached to the stirrer, and then immersed in a solution containing the functional material and stirred for a predetermined time. In the cylindrical bobbin or drum using a cylindrical bobbin having a hole or a drum having a rod shape or a hole, when the suture is wound and then immersed in the coating liquid, the coating liquid reaches the suture wound inside, thereby improving the coating effect. . The suture treated with a solution containing the functional material is then dried at room temperature or, if necessary, using a heater.

In another aspect of the present invention, a process for preparing a suture using a copolymer obtained by polymerizing two or more monomers including a functional material or a polymer obtained by polymerizing a functional material is performed according to a known method for preparing a suture. It is good to manufacture. For example, the polymer prepared by the known method may be prepared by a surgical suture by spinning after stretching by conventional melt spinning method of synthetic fibers. At this time, the optimal draw ratio is not clearly determined, but 3 to 15 times is better and 6 to 10 times is better. By stretching, the filaments are strongly oriented to obtain sufficient flexibility and strong tensile strength suitable for the procedure. If the draw ratio is less than three times, the suture is over-flexible and lacks tensile strength, and if it exceeds 15 times, it tends to lack flexibility.

As described above, the suture is coated with a functional material, or a copolymer or homopolymer obtained by using the functional material as a monomer is prepared as a suture, and inserted between the dermal layer of the skin and the subcutaneous fat layer. The inherent functionalities of the material, for example, it can provide skin moisturizing, antioxidant activity, hair loss prevention, or at the same time provide treatment and prevention of various diseases.

FIG. 2 is a configuration example of a device for inserting a skin according to a first embodiment of the present invention, which is used to insert a procedure thread between a skin dermis layer and a subcutaneous fat layer, and shows a specific insertion position in FIG. To illustrate.

The apparatus 100 for skin regeneration treatment according to the present invention includes a needle 20 having a hollow portion 21 into which one end of the biodegradable seal 10 is inserted and a handle 22 formed at the end of the needle. The handle 22 is formed by molding in accordance with a known method using a conventional resin material or rubber material is fixed by inserting at the end of the needle. One end of the biodegradable seal 10 is inserted into the opening portion 20a formed in the attachment of the surgical needle 20 and inserted into the hollow portion 21.

3 is a configuration example of the skin insertion apparatus according to the second embodiment of the present invention, there is a difference in the handle 22 and the skin insertion apparatus according to the first embodiment. The handle 22 of the skin insertion procedure apparatus according to the second embodiment is made integrally with the needle 20 to attach the thumb and middle finger to the left and right grooves 22a of the handle, and place the index finger on the upper recess. It is possible to ensure that the position of the opening 20a of the needle 20 can always be in a constant position.

Hereinafter, a description will be given of the procedure using the surgical needle 20 including the biodegradable yarn 100 according to the present invention having the configuration as described above.

The surgical needle 20 is inserted between the skin dermis layer and the subcutaneous fat layer of the patient by the operator as shown in FIG. 3. After the operator grasps the handle 22 and inserts the needle into the surgical site of the operator to the desired position, and the operator removes the needle, the biodegradable seal 10 inserted into the needle in this process is pressed against the skin dermis and subcutaneous fat layer. It is detached from the needle and left in place.

In this case, the biodegradable yarn 10 remaining on the skin continuously stimulates the subcutaneous tissue and increases the production of collagen and elastin, and after a certain time, it is decomposed and removed, and the skin is regenerated to provide elasticity.

In addition, when the functional material included in the biodegradable seal 10 is a moisturizer such as hyaluronic acid, it remains in the skin dermis layer to fill the gap between collagen and elastin to provide elasticity and provide moisturizing power deep into the skin to further improve skin regeneration effect. have.

FIG. 5 shows an example in which a hyaluronic acid is coated with a functional material on a surgical chamber and then a surgical needle is used on a forehead of a patient. This experiment was conducted to compare the conditions of two months after the procedure (A) and two months after the procedure thread was inserted between the dermis and subcutaneous fat layer on the forehead of the forehead. This shows that the wrinkles on the forehead are completely removed.

As described above, the present invention can be applied to human skin, for example, the skin of all parts where wrinkles such as face, neck, arms, hips, hands, etc. can be wrinkled, so that the skin can be removed without side effects in a short time by a simple and inexpensive procedure. Provides a resilient effect.

As described above, it has been described with reference to a preferred embodiment of the present invention, but those skilled in the art various modifications and changes of the present invention without departing from the spirit and scope of the invention described in the claims below I can understand that you can.

Claims

Skin insertion procedure consisting of a biodegradable thread.
Biodegradable seals; And a functional material coated on the biodegradable yarn or constituting a biodegradable yarn.
A skin insertion chamber comprising a biodegradable yarn or a functional material coated on or constituting the biodegradable yarn; And a surgical needle having one end of the surgical chamber accommodated therein and having a hollow portion in which the thread can be separated upon insertion into the skin.
The method of claim 3, wherein

A device for skin insertion, characterized in that the handle is formed integrally with the needle at the end of the needle.
The method of claim 2,

The functional material is a skin insertion procedure room, characterized in that at least one selected from skin moisturizers, amino acids, antioxidants, antioxidant enzymes, drugs, herbal extracts, and mushroom extracts.
The method of claim 5,

The drug is alopecia, magnesium salicylate, salsalate, acetaminophen, diclofenac, eto, anti-hair loss, erectile dysfunction, insulin, LHRH, collagen, ceramide, elastin, calcium hydroxy apatite, nonsteroidal analgesic Dolac, Phenoprofen, Flubiprofen, Ibuprofen, Indomethacin, Ketoprofen, Meclofenamate, Meloxycham, Nabumethone, Naproxen, Pyroxycam, Suldinak, Tolmetin, Zatoprofen, Celecoxib, valdecoxib, and rofecoxib, cortisol, prednisone, prednisolone, methylprednisolone, prdrocortisol, cortisone, triamcinolone, betamethasone and dexamethasone as steroids, codeine, morphine sulfate, hydromorphine HCl , Morphine HCl, Fetidine HCl, Codeine Phosphate, Fentanyl, Oxycodone HCl, and Tramadol, Male Hormone, Female Hormone, Sex At least one selected from intestinal hormones and thyroid hormones, the procedure for skin insertion.
A drug carrier for skin insertion, characterized in that the drug is coated on the treatment chamber of claim 1.