KR20160112697A - Fiber for operation and the operation device comprising the same - Google Patents

Abstract

Provided is a skin-insertable functional yarn which comprises: a biodegradable yarn of which a terminal end has a bent portion having a plurality of projections formed along a longitudinal direction; and at least one substance selected among a mushroom extract, a herb medicine extract, a drug, an antioxidant enzyme, an antioxidant substance, amino acid, and a skin moisturizer, making up the biodegradable yarn or coated on the biodegradable yarn.

Description

TECHNICAL FIELD [0001] The present invention relates to a functional seal for skin insertion,

The present invention relates to a surgical thread and a surgical device including the same. More particularly, the present invention relates to a surgical thread and a surgical device including the same. More particularly, (DDS: Drug Delivery System), and a treatment device including the treatment chamber. The present invention also relates to a treatment device for treating a skin of a patient.

Skin is the largest organ in the human body. The skin protects the human body from surrounding toxic substances and microorganisms and prevents water evaporation. In general, human skin consists of two tissue layers. One is an epidermis that is angled and stratified, and another is a basal layer of dermal connective tissue rich in collagen that provides support and nutrition.

Skin aging is known to be caused by cell mutations, active oxygen radicals, accumulation of toxic substances, and deformation of the skin-gap constituent protein, and despite numerous studies of its exact cause, It is not known how to form the skin, and the result of aging is caused by wrinkles of the skin, decreased elasticity, and spot formation. In addition, the collagen production ability which is closely related to the healthy skin is decreased and the abnormal collapse of these collagen fibers is increased, so that the skin elasticity is remarkably lowered. Also, the hyaluronic acid which is responsible for skin moisturization and the glycosaminoglyle It has been reported that the amount of production of the flame is remarkably lowered.

To date, numerous substances have been used to inhibit skin aging. Vitamin C, SOD, Vitamin E, and β-carotene, which have been used for a long time, β-carotene, etc.) are known to alleviate skin aging through its antioxidant effects, thereby improving wrinkles and improving skin elasticity.

Recently, a lot of natural materials have been attracting attention due to the flow of herbal cosmetics. However, it has been known that such methods do not achieve satisfactory results in a short time in relation to the skin regeneration and wrinkle removal effect.

In addition, therapeutic drugs such as insulin have been administered by intraperitoneal injection or transdermal administration. However, many of these drugs have been studied for sustained-release preparations with release characteristics because they are generally not released into the human body and drug effects are not maintained continuously. Usually, they are mixed with ingredients such as binders and biodegradable polymers to form a shell Most formulations are one.

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made in order to solve the problems of the prior art as described above, and its object is to stimulate the subcutaneous tissue by inserting between the dermal layer and the subcutaneous fat layer to increase the production of collagen and elastin, And a biodegradable treatment chamber for inserting the skin.

Another object of the present invention is to provide a treatment chamber for insertion of a skin, which is used as a drug delivery system (DDS: Drug Delivery System), by further enhancing the skin regeneration by incorporating a functional material into the thread. .

Yet another object of the present invention is to provide a method for stimulating skin regeneration by stimulating subcutaneous tissue by inserting between a dermal layer and subcutaneous fat layer to increase the production of collagen and elastin to promote skin regeneration and at the same time, (DDS: Drug Delivery System), which is used for a more powerful effect of the drug delivery system.

The technical problem of the present invention as described above is achieved by the following means.

(1) a biodegradable chamber having a bent portion at its distal end, wherein the bent portion has a plurality of projections in a longitudinal direction; And at least one substance selected from a skin moisturizing agent, an amino acid, an antioxidant, an antioxidant enzyme, a drug, a herbal medicine extract, and a mushroom extract, which is coated or biodegradable on the biodegradable chamber .

(2) The functional skin for inserting skin according to claim 1; And a surgical needle for receiving one end of the functional room and having a hollow portion through which the thread can be separated when the skin is inserted into the skin.

(3) The method according to claim 2,

And a handle formed integrally with the needle is formed at the distal end of the needle.

According to the present invention, by inserting between the dermal layer and the subcutaneous fat layer, the subcutaneous tissue is stimulated to increase the production of collagen and elastin to promote skin regeneration, and at the same time, the functional substance or drug is coated on the thread, It can also be used as an enhanced effect or as a Drug Delivery System (DDS).

1 is a sectional view of a treatment chamber for inserting a skin according to the present invention.
2 is a configuration example of a treatment device according to the first embodiment of the present invention.
3 is a configuration example of a treatment device according to a second embodiment of the present invention.
FIG. 4 is a view showing a position where a treatment device according to the present invention is inserted. FIG.
5 is a photograph before and after the procedure according to the present invention [A: before the operation, B: after the operation]

The present invention relates to a biodegradable chamber having a bent portion at its distal end and a plurality of protrusions formed in a longitudinal direction at the bent portion; And at least one substance selected from a skin moisturizing agent, an amino acid, an antioxidant, an antioxidant enzyme, a drug, a herbal medicine extract, and a mushroom extract, which is coated or biodegradable on the biodegradable chamber .

Hereinafter, the contents of the present invention will be described in more detail.

The treatment room for inserting a skin according to the present invention shown in FIGS. 1 to 3 is excellent in the skin regeneration effect. When the functional material is reinforced, it does not need to be injected or injected periodically, The drug delivery system can function as a kind of drug delivery system.

A more preferred embodiment of the present invention is a biodegradable surgical instrument (10) comprising a biodegradable chamber (10) in which a distal end is bent and a plurality of protrusions (10a) are formed in the longitudinal direction at the bent portion; And a functional material (11) constituting a coated or biodegradable seal on the biodegradable chamber.

In the present invention, the treatment chamber 10 has a bent portion at its distal end, and a plurality of protrusions 10a are formed at the bent portion in the longitudinal direction, so that the thread can be stably fixed even after being inserted into the subcutaneous .

Such a treatment room 10 can be any material which is decomposed in vivo and at the same time is harmless to the human body and can be used as a surgical suture. Examples of such sutures include natural fibers such as cat gut, silk and the like, kitsulose fiber, polyglycolide, polylactide, polyglycolide-lactide copolymer, polycaprolactam and its copolymer, Poly (p-dioxane) and an absorbable degradable suture such as a copolymer thereof.

In the present invention, the surface of these threads may be coated with a functional material, or a polymer synthesized by adding a functional material as a monomer in the course of synthesizing a thread (for example, a surgical suture) may be used . In some cases, the functional material itself can be used as a raw material to produce a suture.

In the present invention, the functional material may be selected from skin moisturizers, amino acids, antioxidants, antioxidant enzymes, drugs, herbal extracts, and mushroom extracts.

Examples of the skin moisturizing agent include hyaluronic acid which is capable of subcutaneous administration.

Examples of the various amino acids include histidine, isoleucine, leucine, lysine, methionine, threonine, valine, alanine, arginine, asparagine, aspartic acid, cystine, cystine, glutamic acid, glutamine, glycine, ornithine, proline, serine, taurine, tyrosine And the like.

Examples of the antioxidant include polyphenol, coenzyme Q10, vitamin C, idebanone, anthocyanin, alpha tocopherol, fiber, omega-3,6,9, phytosterol, Beta-carotene, melatonin, carotenoids, flavonoids, iron, manganese, zinc, selenium, eneacetylcysteine, catechin, lutein, sesamin, quercetin, alliin, EGF, alpha lipoic acid, theanine, resveratrol, lycopene, Senosides, and the like.

Examples of the antioxidant enzymes include SOD [Super Oxide Dismutase], Catalase, and Gpx [Glutathione peroxidase].

In the above, the drug is not particularly limited as long as it is a drug which is basically forbidden to be administered to the skin. Examples of preferred drugs in the present invention include minoxidil, pinasteride, propecia and the like as various depilatory remedies, and examples of the various erectile dysfunction drugs include Viagra, Cialis, Poonggi Dan, Xinyang Dan, In addition, there are other drugs such as insulin, a sustained-release drug such as LHRH, collagen, ceramide, elastin, calcium hydroxyapetite, nonsteroidal antiinflammatory agents such as aspirin, magnesium salicylate, But are not limited to, acetaminophen, diclofenac, etodolac, fenoprofen, fluviprofen, ibuprofen, indomethacin, ketoprofen, meclofenamate, meloxicam, nabumetone, naproxen, , Tolmetin, zatoprofen, celecoxib, valdecoxib, and rofecoxib, cortisol as steroid, prednisone, prednisolone, methylfred At least one selected from the group consisting of atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, atorvastatin, Hormones such as male hormones (testosterone, etc.), female hormones (such as estrogen), growth hormones, and thyroid hormones. The medicament may include all oral, parenteral and topical application medicaments.

In the above, the herbal medicine component extract includes various herbs, fruits, extracts of fruits and their fermented extracts. For example, Hwangjung, iris, chrysanthemum, ginseng, ginseng, astringent, liquorice, bamboo, bamboo, bamboo, bamboo, bamboo, bamboo, bamboo, bamboo, , Cinnamon, cinnamon, cinnamon, cinnamon, cedar, green tea, dwarf, kelp, monkfish, angelica, jujube, dodok, bellflower, acorn, Donga, camellia, Pomegranate, dandelion, mint, barley, peach, loquat leaf, mulberry leaf, raspberry, cornstarch, apricot, apricot, pimento, ginger, pomegranate, pine needles, wormwood, avocado, Flower, chrysanthemum, dumpling, flower, chrysanthemum, flower, chrysanthemum, chrysanthemum, chrysanthemum, chrysanthemum, chrysanthemum, chrysanthemum, Chrysanthemum flower, Asai berry, blueberry, persimmon, New Year, Daebong city, dried persimmon, tangerine, kumquat, heart citrus, 낑 Mango, mangosteen, plum, melon, yang meron, papaya melon, banana, monkey banana, chestnut, peach, nectarine, apple, red rose, strawberry, strawberry, raspberry, lime, rambutan, red globe, lemon, longan, Extracts such as apricot, pomegranate, watermelon, avocado, palm, orange, grapefruit, melon, chrysanthemum, cherry, kiwi, coconut, tomato, drop tomato, pineapple, papaya, grape, blueberry, broccoli and the like.

The mushroom extracts include various mushroom extracts, mushroom mycelium cultures, and fermented extracts. For example, mushroom extracts, mushroom mycelium cultures, and fermented extracts, Mushroom, mushroom mushroom, mushroom mushroom, throat mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, chestnut mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, mushroom mushroom, shiitake mushroom And the like.

A biodegradable thread or a biodegradable thread prepared from a polymerized polymer or functional chamber coated with a functional material in the biodegradable thread is inserted between the dermal layer and the subcutaneous fat layer to stimulate the subcutaneous tissue to increase the production of collagen and elastin, . At the same time, when the functional material is contained, the functional material is gradually released into the skin, thereby providing an effect of gradually sustaining the effect. For example, when the functional substance is hyaluronic acid, it imparts an effect of improving the moisturizing effect and elasticity by transferring moisture deep into the skin. In the case of coating with minoxidil as a hair loss treatment agent, if a thread is inserted on the scalp side, And provides a continuous effect of treating hair loss. In the case of drugs such as insulin, the insulin is gradually supplied to the blood vessels by coating them on the skin and inserting them into the skin, thereby continuously providing the effect of diabetes treatment. In this case, the treatment room for inserting a skin according to the present invention functions as a drug delivery system (DDS) which has not been reported in the past. In particular, the present invention can more preferably be used for a drug that needs to be slowly released, such as luteinizing hormone releasing hormone (LHRH), in addition to insulin.

Hereinafter, a detailed description will be given of a manufacturing process of a treatment chamber for inserting a skin according to the present invention. Hereinafter, the treatment room will be described using sutures as an example.

First, in order to coat the functional material on the suture, a suture prepared in advance is wound on a cylindrical bobbin or a drum, and the suture is attached to a stirrer, followed by immersing in a solution containing a functional substance and stirring for a certain period of time. In the above, the cylindrical bobbin or drum can be used by using a cylindrical bobbin having a hole, or by using a drum having a rod shape or a hole, when the suture is wound and then immersed in the coating solution, the coating solution reaches the inner suture wound to improve the coating effect . The suture treated with the solution containing the functional substance is dried at room temperature or, if necessary, dried using a heater.

In another aspect of the present invention, a process for producing a suture using a polymer prepared by polymerizing two or more monomers including a functional substance or a polymer obtained by polymerizing a functional substance may be carried out according to a known method for producing a suture . For example, the polymer prepared by the above-described known methods may be prepared by spinning by conventional melt-spinning method of synthetic fibers, followed by stretching to make a surgical suture. At this time, although the optimum stretching ratio is not clearly determined, it is preferably 3 to 15 times, more preferably 6 to 10 times. The filaments are strongly oriented by stretching, so that sufficient flexibility and strong tensile strength suitable for the treatment can be obtained. If the stretching magnification is less than 3 times, the suture is excessively flexible and the tensile strength is insufficient. If the suture exceeds 15 times, the flexibility tends to be insufficient.

As described above, a suture is coated with a functional material or a copolymer or a homopolymer obtained by using a functional material as a monomer is prepared as a suture and inserted between the dermal layer and the subcutaneous fat layer of the skin, The inherent functionality of the material allows, for example, skin moisturization, antioxidant activity, prevention of hair loss, or treatment and prevention of various diseases at the same time.

FIG. 2 is a configuration example of a device for inserting a skin according to a first embodiment of the present invention, and is a device used for inserting a procedure room between a skin dermal layer and a subcutaneous fat layer. .

The apparatus for treating skin regeneration according to the present invention comprises a needle 20 having a hollow portion 21 into which one end of the biodegradable chamber 10 is inserted and a handle 22 formed at the distal end of the needle. The knob 22 is made of a conventional resin material or a rubber material and molded by molding according to a known method, and is inserted and fixed at the end of the needle. One end of the biodegradable chamber 10 is inserted into the opening portion 20a formed in the attachment of the surgical needle 20 and inserted into the hollow portion 21. [

FIG. 3 is a structural example of a device for inserting a skin according to a second embodiment of the present invention, which differs from the device 22 for a skin insertion device according to the first embodiment. The handle 22 of the apparatus for inserting a skin according to the second embodiment is integrally formed with the needle 20 and attaches the thumb and the stop to the left and right grooves 22a of the handle, So that the position of the opening 20a of the needle 20 can always be set at a constant position.

Hereinafter, a procedure using the surgical needle 20 including the biodegradable chamber 100 according to the present invention will be described.

The operation needle 20 is inserted between the dermal layer of the patient and the subcutaneous fat layer by the practitioner as shown in Fig. When the practitioner holds the handle 22 and inserts the needle to the desired position of the practitioner, the operator removes the needle. In this process, the biodegradable thread 10 inserted into the needle presses the skin dermal layer and subcutaneous fat layer So that it remains in place after being separated from the needle.

In this case, the biodegradable thread (10) remaining on the skin continuously stimulates the subcutaneous tissues and increases the production of collagen and elastin. After a certain period of time, it is decomposed and removed, and the skin is regenerated to provide elasticity.

In addition, when the functional material contained in the biodegradable chamber 10 is a moisturizing agent such as hyaluronic acid, it remains in the skin dermis layer to provide elasticity between the collagen and the elastin, and provides moisture to the deep part of the skin, have.

FIG. 5 shows an example in which a hyaluronic acid is coated on a treatment chamber with a functional material and the treatment is performed on a patient's forehead using a surgical needle. This experiment was performed to compare the state of (B) after 2 months with the procedure room inserted between the dermal layer and the subcutaneous fat layer at the lower part of the wrinkle before the procedure (A) , Indicating that the wrinkles on the forehead have been completely removed.

Thus, the present invention can be applied to skin of any part where wrinkles such as face, neck, arms, buttocks, hands, etc. can be generated, so that the skin can be easily and cheaply administered within a short period of time Thereby providing an effect of resilient regeneration.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims. It can be understood that

10: Practice room
10a: projection
11; Functional material
20: Surgical needle
20a: opening
21:
22: Handle

Claims (3)

A biodegradable chamber having a bent portion at its distal end and having a plurality of protrusions in the longitudinal direction at the bent portion; And at least one substance selected from a skin moisturizing agent, an amino acid, an antioxidant, an antioxidant enzyme, a drug, a herbal medicine extract, and a mushroom extract, which is coated or biodegradable on the biodegradable chamber . A functional skin for inserting skin according to claim 1; And a surgical needle for receiving one end of the functional room and having a hollow portion through which the thread can be separated when the skin is inserted into the skin. 3. The method of claim 2,
And a handle formed integrally with the needle is formed at the distal end of the needle.

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