CN105296121A - Medical apparatus lubricating oil and preparation method thereof - Google Patents
Medical apparatus lubricating oil and preparation method thereof Download PDFInfo
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- CN105296121A CN105296121A CN201510783365.0A CN201510783365A CN105296121A CN 105296121 A CN105296121 A CN 105296121A CN 201510783365 A CN201510783365 A CN 201510783365A CN 105296121 A CN105296121 A CN 105296121A
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- lubricating oil
- oil
- polyvinylpyrrolidone
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Abstract
The invention discloses medical apparatus lubricating oil. The medical apparatus lubricating oil is composed of the following compositions in percent by weight: 10-15% of wheat germ oil, 1-5% of carboxymethyl cellulose, 2-6% of polyvinylpyrrolidone, 0.1-2% of amethocaine, 1-5% of mythyl p-hydroxybenzoate, 0.5-3% of tween-80, and the balance deionized water. The invention also discloses a preparation method for the above medical apparatus lubricating oil. The plant-oil-base medical apparatus lubricating oil is prepared by employing plant oil, the surfactant and an anaesthesia medicament, can form a protective membrane on an apparatus surface, is low in foam, green, friendly to environment and good in sterilization effect, possesses certain anaesthesia pain-relieving effect, and is capable of mitigating adverse influence of medical apparatuses to patients during usage.
Description
Technical field
The present invention relates to a kind of medicinal preparation, particularly relating to a kind of medical equipment lubrication has and preparation method thereof.
Background technology
A lot of medicine equipment all can cause mechanical injuries to human body to some extent when going deep in human body, and use medical equipment lubricating oil at utmost may reduce the damage to bodily tissue, mucous membrane.
At present, the medical lubricant on market mainly contains soluble oil, silicone lubricant, lubricating oil three class, and wherein, lubricating oil is ideal medical lubricant, its wide material sources, with low cost, safe and non-stimulating.Therefore, in medicinal therapeutic process, lubricating oil is the most desirable, safest medical lubricant.Use lubricating oil effectively can prevent and treat medical equipment to get rusty, extend work-ing life of medical equipment.
But medical equipment lubricating oil conventional is at present mostly mineral oil based lubricating oil, but there is the shortcoming making the airtight and inadequate environmental protection of skin, mucous membrane in mineral oil, therefore, developing a kind of water miscible plant oil based medical equipment lubricating oil is a problem urgently to be resolved hurrily.
Summary of the invention
In order to solve the problem, the invention provides a kind of low bubble, environmental protection, there is the water-soluble plant oil base medical equipment lubricating oil of antibacterial effect and pain relieving anaesthetic effect.
The technical solution used in the present invention is: a kind of medical equipment lubricating oil, calculate by weight and be made up of following component: wheatgerm oil 10-15%, Walocel MT 20.000PV 1-5%, polyvinylpyrrolidone 2-6%, tetracaine 0.1-2%, methyl p-hydroxybenzoate 1-5%, tween-80 0.5-3%, surplus is deionized water.
Further, described polyvinylpyrrolidone is polyvinylpyrrolidone-K30.
Further, calculate by weight and be made up of following component: wheatgerm oil 11.5%, Walocel MT 20.000PV 2.4%, polyvinylpyrrolidone-K303.6%, tetracaine 0.5%, methyl p-hydroxybenzoate 4.5%, tween-80 1.2%, surplus is deionized water.
Or calculate by weight and be made up of following component: wheatgerm oil 14.2%, Walocel MT 20.000PV 4.2%, polyvinylpyrrolidone-K304.2%, tetracaine 1.3%, methyl p-hydroxybenzoate 3.2%, tween-80 2.2%, surplus is deionized water.
Present invention also offers the preparation method of above-mentioned medical equipment lubricating oil, its concrete steps are as follows: the parts by weight by formula are calculated the described Walocel MT 20.000PV obtained by (1), polyvinylpyrrolidone, tetracaine, methyl p-hydroxybenzoate, tween-80, the water of surplus to add in mixing tank vibrating dispersion at 25-35 DEG C, rotating speed is 800-1200rpm, jitter time is that 0.5-1h (2) slowly joins in the said mixture in mixing tank by calculating by the parts by weight of filling a prescription the wheatgerm oil obtained, vibrating dispersion at 40-50 DEG C, rotating speed is 1500-1800rmp, jitter time is 20-40min, namely medical equipment lubricating oil is obtained.
Beneficial effect of the present invention:
The present invention's plant oil based medical equipment lubricating oil that adopted vegetables oil, tensio-active agent, anaesthetic to prepare; protective membrane can be formed at equipment surfaces; and low bubble, green, environmental protection; good anti-bacterial effect; and there is certain narcotic analgesic effect, can alleviate in the use procedure of medicine equipment the detrimentally affect that patient causes.
Embodiment
Embodiment 1:
Calculate by weight and be made up of following component: wheatgerm oil 10%, Walocel MT 20.000PV 1%, polyvinylpyrrolidone-K302%, tetracaine 0.1%, methyl p-hydroxybenzoate 1%, tween-80 0.5%, surplus is deionized water.
Its preparation process step: (1) parts by weight by formula are calculated obtain described Walocel MT 20.000PV, polyvinylpyrrolidone-K30, tetracaine, methyl p-hydroxybenzoate, tween-80, surplus water to add in mixing tank vibrating dispersion at 25-35 DEG C, rotating speed is 800rpm, jitter time is that 0.5h (2) slowly joins in the said mixture in mixing tank by calculating by the parts by weight of filling a prescription the wheatgerm oil obtained, vibrating dispersion at 40 DEG C, rotating speed is 1500rmp, jitter time is 20min, namely obtains medical equipment lubricating oil.
Embodiment 2:
Calculate by weight and be made up of following component: wheatgerm oil 15%, Walocel MT 20.000PV 5%, polyvinylpyrrolidone-K306%, tetracaine 2%, methyl p-hydroxybenzoate 5%, tween-80 3%, surplus is deionized water.
Its preparation process step: (1) parts by weight by formula are calculated obtain described Walocel MT 20.000PV, polyvinylpyrrolidone-K30, tetracaine, methyl p-hydroxybenzoate, tween-80, surplus water to add in mixing tank vibrating dispersion at 35 DEG C, rotating speed is 1200rpm, jitter time is that 1h (2) slowly joins in the said mixture in mixing tank by calculating by the parts by weight of filling a prescription the wheatgerm oil obtained, vibrating dispersion at 50 DEG C, rotating speed is 1800rmp, jitter time is 40min, namely obtains medical equipment lubricating oil.
Embodiment 3:
Calculate by weight and be made up of following component: wheatgerm oil 11.5%, Walocel MT 20.000PV 2.4%, polyvinylpyrrolidone-K303.6%, tetracaine 0.5%, methyl p-hydroxybenzoate 4.5%, tween-80 1.2%, surplus is deionized water.
Its preparation process step: (1) parts by weight by formula are calculated obtain described Walocel MT 20.000PV, polyvinylpyrrolidone-K30, tetracaine, methyl p-hydroxybenzoate, tween-80, surplus water to add in mixing tank vibrating dispersion at 25 DEG C, rotating speed is 1000rpm, jitter time is that 0.5h (2) slowly joins in the said mixture in mixing tank by calculating by the parts by weight of filling a prescription the wheatgerm oil obtained, vibrating dispersion at 40 DEG C, rotating speed is 1500rmp, jitter time is 20min, namely obtains medical equipment lubricating oil.
Embodiment 4:
Calculate by weight and be made up of following component: wheatgerm oil 14.2%, Walocel MT 20.000PV 4.2%, polyvinylpyrrolidone-K304.2%, tetracaine 1.3%, methyl p-hydroxybenzoate 3.2%, tween-80 2.2%, surplus is deionized water.
Its preparation process step: (1) parts by weight by formula are calculated obtain described Walocel MT 20.000PV, polyvinylpyrrolidone-K30, tetracaine, methyl p-hydroxybenzoate, tween-80, surplus water to add in mixing tank vibrating dispersion at 25 DEG C, rotating speed is 1000rpm, jitter time is that 0.5h (2) slowly joins in the said mixture in mixing tank by calculating by the parts by weight of filling a prescription the wheatgerm oil obtained, vibrating dispersion at 40 DEG C, rotating speed is 1500rmp, jitter time is 20min, namely obtains medical equipment lubricating oil.
Embodiment 5:
Embodiment 1-4 fill a prescription the medical operation that obtains after the medical equipment lubricating oil that obtains soaks cut to cut with the medical operation not carrying out coating processing compared with its various aspects of performance see the following form:
Table 1 test-results
Embodiment 6:
Get the earthworm of heavy 0.5-5g, be divided into 5 groups, be respectively embodiment 14 groups and control group, often organize 20, be stored in water content be 25-30% containing in humus soil, by 2h in the Ringer liquid of it immigrations ventilation before experiment, during experiment, 5 groups of earthworms enter in the liquid of each group respectively.Often group gets 1min in 3 immersion 300mL0.0125mol/LHCl solution in 1,3,5,8,12 and 16min, observes sharply withdrawing reaction, calculates its side reaction number, be calculated as follows anesthetic index:
Anesthetic index=negative reaction number/experiment earthworm number × 100%
The anesthetic index of each group of earthworm is as shown in the table:
Table 2 anesthetic index measurement result
| Anesthetic index/% | |
| Embodiment 1 | 86 |
| Embodiment 2 | 87 |
| Embodiment 3 | 92 |
| Embodiment 4 | 94 |
| Control group | 0 |
As seen from the above table, the emulsifying agent in medical equipment lubricant formula of the present invention, oil base, narcotic are selected appropriate, improve narcotic solute effect, therefore obtain good anaesthetic effect.
Above-described embodiment, just in order to technical conceive of the present invention and feature are described, its objective is and is one of ordinary skilled in the art can be understood content of the present invention and implement according to this, can not limit the scope of the invention with this.The change of every equivalence done by the essence of content of the present invention or modification, all should be encompassed in protection scope of the present invention.
Claims (5)
1. a medical equipment lubricating oil, it is characterized in that, calculate by weight and be made up of following component: wheatgerm oil 10-15%, Walocel MT 20.000PV 1-5%, polyvinylpyrrolidone 2-6%, tetracaine 0.1-2%, methyl p-hydroxybenzoate 1-5%, tween-80 0.5-3%, surplus is deionized water.
2. a kind of medical equipment lubricating oil as claimed in claim 1, is characterized in that, described polyvinylpyrrolidone is polyvinylpyrrolidone-K30.
3. a kind of medical equipment lubricating oil as described in any one of claim 1 or 2, it is characterized in that, calculate by weight and be made up of following component: wheatgerm oil 11.5%, Walocel MT 20.000PV 2.4%, polyvinylpyrrolidone-K303.6%, tetracaine 0.5%, methyl p-hydroxybenzoate 4.5%, tween-80 1.2%, surplus is deionized water.
4. a kind of medical equipment lubricating oil as described in any one of claim 1 or 2, it is characterized in that, calculate by weight and be made up of following component: wheatgerm oil 14.2%, Walocel MT 20.000PV 4.2%, polyvinylpyrrolidone-K304.2%, tetracaine 1.3%, methyl p-hydroxybenzoate 3.2%, tween-80 2.2%, surplus is deionized water.
5. a kind of medical equipment lubricating oil as described in any one of claim 1-4, it is characterized in that: the parts by weight by formula are calculated the described Walocel MT 20.000PV obtained by (1), polyvinylpyrrolidone, tetracaine, methyl p-hydroxybenzoate, tween-80, the water of surplus to add in mixing tank vibrating dispersion at 25-35 DEG C, rotating speed is 800-1200rpm, jitter time is that 0.5-1h (2) slowly joins in the said mixture in mixing tank by calculating by the parts by weight of filling a prescription the wheatgerm oil obtained, vibrating dispersion at 40-50 DEG C, rotating speed is 1500-1800rmp, jitter time is 20-40min, namely medical equipment lubricating oil is obtained.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510783365.0A CN105296121A (en) | 2015-11-11 | 2015-11-11 | Medical apparatus lubricating oil and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510783365.0A CN105296121A (en) | 2015-11-11 | 2015-11-11 | Medical apparatus lubricating oil and preparation method thereof |
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| CN105296121A true CN105296121A (en) | 2016-02-03 |
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| CN201510783365.0A Pending CN105296121A (en) | 2015-11-11 | 2015-11-11 | Medical apparatus lubricating oil and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107011962A (en) * | 2017-06-08 | 2017-08-04 | 苏州瑞奇丽新材料有限公司 | A kind of aqueous lubricating oil |
| CN107446665A (en) * | 2017-08-14 | 2017-12-08 | 吴江华威特种油有限公司 | A kind of antibacterial anti-corrosion grease of food-grade and preparation method thereof |
| CN107446676A (en) * | 2017-08-14 | 2017-12-08 | 吴江华威特种油有限公司 | A kind of wear-resisting high tack food machinery lubricant and preparation method thereof |
Citations (4)
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| EP0581581A3 (en) * | 1992-07-29 | 1996-01-17 | Johnson & Johnson Consumer | Bioadhesive treatment compositions and methods of use |
| CN101703814A (en) * | 2009-11-24 | 2010-05-12 | 张干元 | Lubricating agent for use in coelom introduction by medicinal appliance |
| CN103436341A (en) * | 2013-08-16 | 2013-12-11 | 陕西科技大学 | Plant oil base medical instrument lubricating oil and preparation method thereof |
| CN103933621A (en) * | 2014-04-16 | 2014-07-23 | 广西信业生物技术有限公司 | Medical lubricant and preparation method thereof |
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2015
- 2015-11-11 CN CN201510783365.0A patent/CN105296121A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0581581A3 (en) * | 1992-07-29 | 1996-01-17 | Johnson & Johnson Consumer | Bioadhesive treatment compositions and methods of use |
| CN101703814A (en) * | 2009-11-24 | 2010-05-12 | 张干元 | Lubricating agent for use in coelom introduction by medicinal appliance |
| CN103436341A (en) * | 2013-08-16 | 2013-12-11 | 陕西科技大学 | Plant oil base medical instrument lubricating oil and preparation method thereof |
| CN103933621A (en) * | 2014-04-16 | 2014-07-23 | 广西信业生物技术有限公司 | Medical lubricant and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中国食品添加剂和配料协会: "《食品添加剂手册》", 30 September 2012, 中国轻工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107011962A (en) * | 2017-06-08 | 2017-08-04 | 苏州瑞奇丽新材料有限公司 | A kind of aqueous lubricating oil |
| CN107446665A (en) * | 2017-08-14 | 2017-12-08 | 吴江华威特种油有限公司 | A kind of antibacterial anti-corrosion grease of food-grade and preparation method thereof |
| CN107446676A (en) * | 2017-08-14 | 2017-12-08 | 吴江华威特种油有限公司 | A kind of wear-resisting high tack food machinery lubricant and preparation method thereof |
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Application publication date: 20160203 |