CN105288695B - Adhesive bandage of the ingredient containing graphene oxide and preparation method thereof - Google Patents
Adhesive bandage of the ingredient containing graphene oxide and preparation method thereof Download PDFInfo
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- CN105288695B CN105288695B CN201510783493.5A CN201510783493A CN105288695B CN 105288695 B CN105288695 B CN 105288695B CN 201510783493 A CN201510783493 A CN 201510783493A CN 105288695 B CN105288695 B CN 105288695B
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Abstract
The invention discloses a kind of adhesive bandages of ingredient containing graphene oxide, belong to the field of medical instrument technology, and technical points include being made of matrix and the active component being coated in matrix, and the active component is mainly made of the component of following parts by weight：0.01 1.5 parts of graphene oxide, 15 parts of ionic liquid, 0.5 3.6 parts of quaternary ammonium salt surface active agent, 0.1 0.5 parts of sodium carboxymethylcellulose, 0.2 0.8 parts of polyacrylamide, 0.5 2.0 parts of tween, 19 parts of polyethylene glycol, 3 12 parts of glycerine, 5 25 parts of medical ventolin, 1 20 parts of deionized water, adhesive bandage treat wound healing of the present invention is fast, it does not scab, it is proved through Clinical Treatment Test, total effective rate 100%, and the anti-inflammation hemostasia of adhesive bandage of the invention prepared, healing up sore and subduing swelling, convergence myogenic and other effects are quite preferable.
Description
Technical field
The present invention relates to medical instruments field, more specifically a kind of adhesive bandage more particularly to one kind contain graphene oxide
Adhesive bandage of ingredient and preparation method thereof.
Background technology
Adhesive bandage is most common a kind of surgical medicine in people's life.Adhesive bandage also known as " hemostasis plaster ", have only
Blood, protective effect.By an elongated adhesive plaster, the sliver that centre is accompanied by the dipped drug of a fritter is formed.Due to its structure
Limitation, adhesive bandage are only used for the wound emergence therapeutic of fritter, so as to play the role of temporary hemostasis, protect the surface of a wound.
2004, British scientist Geim etc. prepared single-layer graphene with mechanical stripping method, causes to graphene
Research boom.Graphene be by single layer of carbon atom it is tightly packed into the carbonaceous material with two dimensional surface honeycomb crystal lattice structure
Material, unique nanostructured determine it with a series of excellent performances.Graphene oxide is the important derivatives of graphene,
Its structure is essentially identical with graphene, still remains layer structure, but many oxygen-containing functional groups are introduced on its lamella, such as
Carboxyl, hydroxyl, epoxy group and carbonyl etc., by solvent stripping or hot soarfing from obtained single layer structure, referred to as graphene oxide.
It, can due to the introducing of oxygen-containing groups a large amount of on surface and edge as the monolayer material stripped down from graphite oxide
It is stabilized in aqueous solution and polar solvent.
The type of adhesive bandage is various currently on the market, but the effect of existing most of adhesive bandage hemostasis shield sore and unknown
It is aobvious：If Chinese patent 201310635082.2 discloses a kind of preparation method of pearl powder adhesive bandage, although disappearing with certain
Inflammation hemostasis, healing up sore and subduing swelling and other effects, but effect is unsatisfactory, and slowly effect；Patent 201210275303.5 discloses one kind
Adhesive bandage of the ingredient containing Khotan jade and preparation method thereof is still substantially Chinese herbal medicine class, though there is certain hemostasia and dissipation blood stasis,
But slowly effect, it needs to use for a long time.
Adhesive bandage is generally mainly made of plain cloth adhesive plaster, water absorption pad, protective layer, and water absorption pad is the most important composition of adhesive bandage
Part is made generally by with hemostasis, anti-inflammatory, sterilized pharmaceutics hybrid process on domestic market, though its treatment effect
Also very significantly, but its duration, durability are less desirable for fruit, and the present invention, which has studied, a kind of uses graphene oxide as ingredient system
Into adhesive bandage can solve problems.But it through retrieval, at home, outer does not find to be configured to for ingredient using graphene oxide
Adhesive bandage product and technology.
Invention content
It is an object of the invention to, provide a kind of to use graphene oxide as ingredient system in view of the above shortcomings of the prior art
Into adhesive bandages, the adhesive bandage for preparing of the present invention has hemostasis, anti-inflammatory, analgesia, biocidal efficacies, to solve in background technology
Existing technological deficiency.
The technical proposal of the invention is realized in this way：
The adhesive bandage of the ingredient containing graphene oxide is made of, the work matrix and the active component being coated in matrix
Property component is mainly made of the component of following parts by weight：0.01-1.5 parts of graphene oxide, 1-5 parts of ionic liquid, quaternary ammonium salt
0.5-3.6 parts of surfactant, 0.1-0.5 parts of sodium carboxymethylcellulose, 0.2-0.8 parts of polyacrylamide, tween 0.5-2.0
Part, 1-9 parts of polyethylene glycol, 3-12 parts of glycerine, 5-25 parts of medical ventolin, 1-20 parts of deionized water.
Further, the active component is mainly made of the component of following parts by weight：Graphene oxide 0.1-1.0
Part, 2-4 parts of ionic liquid, 0.9-3.0 parts of quaternary ammonium salt surface active agent, 0.2-0.4 parts of sodium carboxymethylcellulose, polyacrylamide
0.4-0.6 parts of amine, 0.8-1.5 parts of tween, 2-8 parts of polyethylene glycol, 5-10 parts of glycerine, 10-20 parts of medical ventolin, deionized water
5-15 parts.
Further, the active component is mainly made of the component of following parts by weight：0.8 part of graphene oxide, from
Sub- 3 parts of liquid, 2.5 parts of quaternary ammonium salt surface active agent, 0.3 part of sodium carboxymethylcellulose, 0.5 part of polyacrylamide, tween 1.0
Part, 5 parts of polyethylene glycol, 8 parts of glycerine, 15 parts of medical ventolin, 10 parts of deionized water.
Further, the ionic liquid is N- butyl-pyridiniums hexafluorophosphate, N- butyl-pyridinium tetrafluoroborates 1-
One or more of methylimidazole trifluoroacetate.
Further, the quaternary ammonium salt surface active agent is benzalkonium chloride, benzalkonium bromide, bromination dimethyl didecyl
One or more of ammonium, didecyl Dimethy ammonium chloride.
The preparation method of the adhesive bandage of the ingredient containing graphene oxide, concrete operation step are as follows：(1) prepared by active component；
(2) active component is coated on stromal surface；(3) adhesive bandage shapes, wherein the step (1) includes：(1)：Graphite oxide
It is prepared by aqueous solution：Graphene oxide, surfactant, ionic liquid are added in deionized water according to component number, ultrasound point
Dissipate 10-15min；(2)：The preparation of active component：Under high speed dispersor peptizaiton, remaining component is added in into step (1)
In aqueous solution, continue to stir the active constituent of 5-30min, as gained at room temperature.
Beneficial effects of the present invention：Graphene oxide is applied in adhesive bandage active constituent by the present invention for the first time, is oxidation
The expansion again in the field of graphene application, graphene oxide bactericidal property is remarkable, is the physics " antibiotic " of no drug resistance,
The adhesive bandage of the present invention is soft and smooth, and the permeability of drug is strong, and good air permeability, and arresting bleeding and promoting healting is fast, preparation process
Simply, cheap, wound healing is fast, does not scab, and is proved through Clinical Treatment Test, total effective rate 100%, and prepared by the present invention
The anti-inflammation hemostasia of adhesive bandage, healing up sore and subduing swelling, convergence myogenic and other effects it is quite preferable.
Specific embodiment
With reference to specific embodiment, the present invention is described in further detail, but does not form to any of the present invention
Limitation.
Industrial chemicals explanation：Nanjing Xian Feng Nono-material Science ＆ Technology Ltd. is purchased from containing graphene oxide；Ionic liquid is purchased
From Shanghai Mo Ni Chemical Industry Science Co., Ltd；Other chemical reagent are purchased from Chinese medicines group, food-grade, and all industrial chemicals are
Processing directly uses.
Instrument explanation：Ultrasonic grinder JYD-250 machines are purchased from NingBo XinZhi Biology Science Co., Ltd；IKA
T18 ULTRA-TURRAX high speed dispersors are purchased from IKA companies of Germany.
Embodiment 1
The adhesive bandage of the ingredient containing graphene oxide is made of, the work matrix and the active component being coated in matrix
Property component is mainly made of the component of following parts by weight：0.01 part of graphene oxide, 1 part of ionic liquid, quaternary ammonium salt surface are lived
0.5 part of agent of property, 0.1 part of sodium carboxymethylcellulose, 0.2 part of polyacrylamide, 0.5 part of tween, 1 part of polyethylene glycol, 3 parts of glycerine,
5 parts of medical ventolin, 1-20 parts of deionized water.
Further, the ionic liquid is N- butyl-pyridinium hexafluorophosphates.
Further, the quaternary ammonium salt surface active agent is bromination dimethyl didecyl ammonium.
The preparation method of the adhesive bandage of the ingredient containing graphene oxide, concrete operation step are as follows：(1) prepared by active component；
(2) active component is coated on stromal surface；(3) adhesive bandage shapes, wherein the step (1) includes：(1)：Graphite oxide
It is prepared by aqueous solution：Graphene oxide, surfactant, ionic liquid are added in deionized water according to component number, ultrasound point
Dissipate 10min；(2) preparation of active component：Under high speed dispersor peptizaiton, remaining component is added in into the water-soluble of step (1)
In liquid, continue to stir the active constituent of 5min, as gained at room temperature.
Embodiment 2
The adhesive bandage of the ingredient containing graphene oxide is made of, the work matrix and the active component being coated in matrix
Property component is mainly made of the component of following parts by weight：1.5 parts of graphene oxide, 5 parts of ionic liquid, quaternary ammonium salt surface active
3.6 parts of agent, 0.5 part of sodium carboxymethylcellulose, 0.8 part of polyacrylamide, 2.0 parts of tween, 9 parts of polyethylene glycol, 12 parts of glycerine, doctor
With 25 parts of vaseline, 20 parts of deionized water.
The ionic liquid is 1 part of N- butyl-pyridiniums hexafluorophosphate, 2 parts of N- butyl-pyridiniums tetrafluoroborate, 1- first
1 part of base imidazoles trifluoroacetate.
The quaternary ammonium salt surface active agent is 0.1 part of benzalkonium chloride, 0.2 part of benzalkonium bromide, bromination dimethyl didecyl
2.0 parts of base ammonium, 1.3 parts of didecyl Dimethy ammonium chloride.
The preparation method of the adhesive bandage of the ingredient containing graphene oxide, concrete operation step are as follows：(1) prepared by active component；
(2) active component is coated on stromal surface；(3) adhesive bandage shapes, wherein the step (1) includes：S1：Graphene oxide
It is prepared by aqueous solution：Graphene oxide, surfactant, ionic liquid are added in deionized water according to component number, ultrasonic disperse
15min；(2) preparation of active component：Under high speed dispersor peptizaiton, remaining component is added in the aqueous solution of step (1)
In, continue to stir the active constituent of 30min, as gained at room temperature.
Embodiment 3
The adhesive bandage of the ingredient containing graphene oxide is made of, the work matrix and the active component being coated in matrix
Property component is mainly made of the component of following parts by weight：The active component is mainly made of the component of following parts by weight：Oxygen
0.1 part of graphite alkene, 2 parts of ionic liquid, 0.9 part of quaternary ammonium salt surface active agent, 0.2 part of sodium carboxymethylcellulose, polypropylene
0.4 part of amide, 0.8 part of tween, 2 parts of polyethylene glycol, 5 parts of glycerine, 10 parts of medical ventolin, 5 parts of deionized water.
The ionic liquid is N- butyl-pyridinium tetrafluoroborates.
The quaternary ammonium salt surface active agent is didecyl Dimethy ammonium chloride.
The preparation method of the adhesive bandage of the ingredient containing graphene oxide, concrete operation step are as follows：(1) prepared by active component；
(2) active component is coated on stromal surface；(3) adhesive bandage shapes, wherein the step (1) includes：S1：Graphene oxide
It is prepared by aqueous solution：Graphene oxide, surfactant, ionic liquid are added in deionized water according to component number, ultrasonic disperse
12min；(2) preparation of active component：Under high speed dispersor peptizaiton, remaining component is added in the aqueous solution of step (1)
In, continue to stir the active constituent of 20min, as gained at room temperature.
Embodiment 4
The adhesive bandage of the ingredient containing graphene oxide is made of, the work matrix and the active component being coated in matrix
Property component is mainly made of the component of following parts by weight：1.0 parts of graphene oxide, 4 parts of ionic liquid, quaternary ammonium salt surface active
3.0 parts of agent, 0.4 part of sodium carboxymethylcellulose, 0.6 part of polyacrylamide, 1.5 parts of tween, 8 parts of polyethylene glycol, 10 parts of glycerine, doctor
With 20 parts of vaseline, 15 parts of deionized water.
The ionic liquid is 1- methylimidazole trifluoroacetates.
The quaternary ammonium salt surface active agent is didecyl Dimethy ammonium chloride.
The preparation method of the adhesive bandage of the ingredient containing graphene oxide, with embodiment 1.
Embodiment 5
The adhesive bandage of the ingredient containing graphene oxide is made of, the work matrix and the active component being coated in matrix
Property component is mainly made of the component of following parts by weight：0.8 part of graphene oxide, 3 parts of ionic liquid, quaternary ammonium salt surface active
2.5 parts of agent, 0.3 part of sodium carboxymethylcellulose, 0.5 part of polyacrylamide, 1.0 parts of tween, 5 parts of polyethylene glycol, 8 parts of glycerine, doctor
With 15 parts of vaseline, 10 parts of deionized water.
The ionic liquid is N- butyl-pyridinium hexafluorophosphates.
The quaternary ammonium salt surface active agent is 1.2 parts of bromination dimethyl didecyl ammonium, didecyl Dimethy chlorination
1.3 parts in ammonium.
The preparation method of the adhesive bandage of the ingredient containing graphene oxide, with example 2.
Embodiment 6
Hand knife wound：The male patient of one 30 years old, hand knife wound, area is 4.0cm × 1.0cm, using the wound of embodiment 1
It can paste, after 5 days, wound healing.
Embodiment 7
Band-like scar：Band-like 120, scar is treated with the adhesive bandage of embodiment 4, pain subtracts within 1-2 days, forms a scab and is cured within 3-4 days,
Preventing from scar.
Embodiment 8
Injury gained in sports, which is drawn, hinders varication, and vasculitis causes the patient that bursts, after the adhesive bandage treatment of embodiment 4, wound 5 days
Heal.
1 graphite oxide adhesive bandage of table is to stopping blooding, relieving pain, anti-inflammatory, more sore cardinal symptom observation of curative effect result table
The above described is only a preferred embodiment of the present invention, not make limitation in any form to the present invention, therefore
It is every without departing from technical solution of the present invention content, technical spirit according to the present invention any is simply repaiied to what above example was made
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (6)
1. the adhesive bandage of the ingredient containing graphene oxide is made of matrix and the active component being coated in matrix, it is characterised in that：
The active component is mainly made of the component of following parts by weight：0.01-1.5 parts of graphene oxide, 1-5 parts of ionic liquid,
0.5-3.6 parts of quaternary ammonium salt surface active agent, 0.1-0.5 parts of sodium carboxymethylcellulose, 0.2-0.8 parts of polyacrylamide, tween
0.5-2.0 parts, 1-9 parts of polyethylene glycol, 3-12 parts of glycerine, 5-25 parts of medical ventolin, 1-20 parts of deionized water；It is aoxidized preparing
During graphene aqueous solution, graphene oxide, quaternary ammonium salt surface active agent, ionic liquid are added in into deionized water according to component number
In.
2. the adhesive bandage of the ingredient according to claim 1 containing graphene oxide, it is characterised in that：The active component master
It to be made of the component of following parts by weight：0.1-1.0 parts of graphene oxide, 2-4 parts of ionic liquid, quaternary ammonium salt surface active agent
0.9-3.0 parts, 0.2-0.4 parts of sodium carboxymethylcellulose, 0.4-0.6 parts of polyacrylamide, 0.8-1.5 parts of tween, polyethylene glycol
2-8 parts, 5-10 parts of glycerine, 10-20 parts of medical ventolin, 5-15 parts of deionized water.
3. the adhesive bandage of the ingredient according to claim 1 containing graphene oxide, it is characterised in that：The active component master
It to be made of the component of following parts by weight：0.8 part of graphene oxide, 3 parts of ionic liquid, 2.5 parts of quaternary ammonium salt surface active agent,
0.3 part of sodium carboxymethylcellulose, 0.5 part of polyacrylamide, 1.0 parts of tween, 5 parts of polyethylene glycol, 8 parts of glycerine, medical ventolin
15 parts, 10 parts of deionized water.
4. the adhesive bandage of the ingredient containing graphene oxide according to claim 1-3 any claims, it is characterised in that：Institute
The ionic liquid stated is N- butyl-pyridiniums hexafluorophosphate, N- butyl-pyridiniums tetrafluoroborate, 1- methylimidazole trifluoroacetates
One or more of.
5. the adhesive bandage of the ingredient containing graphene oxide according to claim 1-3 any claims, it is characterised in that：Institute
The quaternary ammonium salt surface active agent stated is benzalkonium chloride, benzalkonium bromide, bromination dimethyl didecyl ammonium, didecyl Dimethy chlorine
Change one or more of ammonium.
6. the preparation method of the adhesive bandage of the ingredient containing graphene oxide according to claim 1-3, it is characterised in that：Specifically
Operating procedure is as follows：(1) prepared by active component；(2) active component is coated on stromal surface；(3) adhesive bandage shapes, wherein
The step (1) includes：S1：It is prepared by graphene oxide water solution：According to component number by graphene oxide, surfactant, from
Sub- liquid is added in deionized water, ultrasonic disperse 10-15min；S2：The preparation of active component：In high speed dispersor peptizaiton
Under, remaining component is added in the aqueous solution of S1, continue to stir the active constituent of 5-30min, as gained at room temperature.
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105617441B (en) * | 2016-03-16 | 2017-04-26 | 腾科宝迪（厦门）生物科技有限公司 | Antibacterial graphene dressing |
| CN105963073A (en) * | 2016-04-22 | 2016-09-28 | 济南圣泉集团股份有限公司 | Microcurrent band-aid |
| CN105879106B (en) * | 2016-05-03 | 2017-08-08 | 腾科宝迪（厦门）生物科技有限公司 | A kind of graphene medical cotton and preparation method thereof |
| CN105919728A (en) * | 2016-07-06 | 2016-09-07 | 瑙ｆ袱 | Externally-applied traditional Chinese medicinal ointment patch for mild moxibustion |
| CN107670088A (en) * | 2016-08-01 | 2018-02-09 | 福建新峰二维材料科技有限公司 | A kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof |
| CN108210990A (en) * | 2016-12-21 | 2018-06-29 | 戴清仪 | It is a kind of using graphene oxide as the new liquid adhesive bandage of antibacterial components |
| DK3691649T3 (en) * | 2017-10-06 | 2022-12-12 | Eluciderm Inc | COMPOSITIONS AND METHODS FOR WOUND TREATMENT |
| CN108096223A (en) * | 2017-12-22 | 2018-06-01 | 南京林业大学 | A kind of graphene oxide repairs the preparation method of wound bandage |
| CN109395152A (en) * | 2018-09-21 | 2019-03-01 | 南通强生石墨烯科技有限公司 | A kind of compound hydrocolloid medical dressing of graphene and preparation method thereof |
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| CN103920179A (en) * | 2014-04-22 | 2014-07-16 | 楚立云 | Graphene wound dressing |
| CN104841002A (en) * | 2015-05-21 | 2015-08-19 | 福建农林大学 | Purely natural mosquito-repellent band-aid and preparation method thereof |
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| KR101648083B1 (en) * | 2014-02-19 | 2016-08-12 | 금오공과대학교 산학협력단 | Antibacterial polyurethane foam dressing material and manufacturing method thereof |
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|---|---|---|---|---|
| CN103920179A (en) * | 2014-04-22 | 2014-07-16 | 楚立云 | Graphene wound dressing |
| CN104841002A (en) * | 2015-05-21 | 2015-08-19 | 福建农林大学 | Purely natural mosquito-repellent band-aid and preparation method thereof |
| CN105012993A (en) * | 2015-08-25 | 2015-11-04 | 东莞市达庆医疗器械有限公司 | Medical and antibacterial cationic biogel dressing and preparation method thereof |
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