CN107670088A - A kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof - Google Patents

A kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof Download PDF

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Publication number
CN107670088A
CN107670088A CN201610622593.4A CN201610622593A CN107670088A CN 107670088 A CN107670088 A CN 107670088A CN 201610622593 A CN201610622593 A CN 201610622593A CN 107670088 A CN107670088 A CN 107670088A
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China
Prior art keywords
restraining
graphene
adhesive tape
sterilizing bacteria
adhesive bandage
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Pending
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CN201610622593.4A
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Chinese (zh)
Inventor
杨与畅
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Fujian Xinfeng Two Mstar Technology Ltd
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Fujian Xinfeng Two Mstar Technology Ltd
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Priority to CN201610622593.4A priority Critical patent/CN107670088A/en
Publication of CN107670088A publication Critical patent/CN107670088A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Abstract

The invention discloses a kind of restraining and sterilizing bacteria adhesive bandage, the restraining and sterilizing bacteria adhesive bandage includes：Adhesive tape, the stenlizing layer being located in the middle part of adhesive tape and it is located on adhesive tape and covers the diaphragm of stenlizing layer, the stenlizing layer is graphene or graphene oxide and P25TiO2It is combined.The present invention prepares graphene fiber or graphene, TiO by electrospinning process2Nanofiber, which is attached on the adhesive tape layer of adhesive bandage, forms stenlizing layer, and design of adhesive tape is beneficial to TiO into transparent2Light-catalysed progress, effective restraining and sterilizing bacteria performance is played, avoid wound infection inflammation, while graphene has extra specific surface area, adsorption capacity is strong, beneficial to keeping wound surface to dry, accelerates the healing rate of wound.

Description

A kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof
Technical field
The present invention relates to sterilization adhesive bandage field, more particularly to a kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof.
Background technology
Adhesive bandage is generally used for the diffusate of wound, keeps wound drying, the protection surface of a wound to prevent to infect, generally Applied in daily life, there is the advantages of easy to use, replacing is quick.Now adhesive bandage major part medication on the market Nitride layer works, and accelerates wound healing；But wound is because of the relatively space of closing and has blood, wound fester etc. easily to cause carefully The growth of bacterium, wound healing is not at, while adhesive bandage material therefor does not have bacteriostasis, accelerates the breeding of bacterium.
Graphene, graphene oxide do not have an impact to human body cell normal development, metabolism, and bacterium can not on graphene Growth, has safely and effectively fungistatic effect, while TiO2Generated when by light the very strong superoxides the moon of chemical activity from Sub- free radical and hydroxyl free radical, organic matter is attacked, has the function that degradable organic pollutant.When running into bacterium, directly attack The cell of bacterium is hit, causes the organic matter degradation in bacterial cell, bacterium is killed with this, and be allowed to decompose
Therefore, it is titanium dioxide P25 and graphene is compound, good photocatalysis performance can be made it have, decomposable asymmetric choice net wound can The bacterium of growth is sticked, accelerates wound healing, solves the effect that existing adhesive bandage does not sterilize pre- bacterium.
The content of the invention
In view of the above-mentioned problems, the invention provides a kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof, solves existing wound Material therefor, which can be pasted, does not have bacteriostasis, and space-closed is in the growth for having blood, wound fester etc. easily to cause bacterium, quickening The breeding of bacterium.
In order to solve the above technical problems, the technical solution adopted in the present invention is：The invention provides a kind of restraining and sterilizing bacteria Adhesive bandage, the restraining and sterilizing bacteria adhesive bandage include：Adhesive tape, the stenlizing layer being located in the middle part of adhesive tape and it is located on adhesive tape and covers and kill The diaphragm of bacterium layer, the stenlizing layer are graphene or graphene oxide and P25TiO2It is combined.
Preferably, the adhesive tape is adhesive tape, and the stenlizing layer is located at adhesive tape middle part, and the diaphragm is adhesive tape The cover layer at both ends.
Preferably, the adhesive tape middle part is additionally provided with air-vent.
The present invention also provides a kind of preparation method of restraining and sterilizing bacteria adhesive bandage, comprises the following steps：Prepare graphene oxide Or graphene；By graphene oxide or graphene and P25TiO2It is combined into sterilization material；Prepare electrostatic spinning liquid；By Static Spinning Silk liquid forms stenlizing layer on adhesive tape.
Preferably, described the step of preparing graphene oxide, includes：2g graphite powders are added in flask, are added under ice-water bath 1gNaNO3With the 46mL concentrated sulfuric acids；6g KMnO is slowly added under magnetic agitation4, temperature be less than 20 DEG C, react 5-60min after remove Ice-water bath；30-40 DEG C is warming up to, 20-60min is reacted, deionized water is slowly added dropwise；Added after stirring reaction 10-30min 60-100mL3wt% hydrogen peroxide solutions, until the lather collapse in reaction system；The ultracentrifugation 10- under rotating speed 7200rpm 30min, then washed repeatedly with watery hydrochloric acid, distilled water successively, until PH is neutrality, obtain crude product；The crude product weight that will be obtained Newly it is dissolved in water, ultrasonic 10-30min, filters out not oxidized graphite residue；Obtain graphene oxide.
Preferably, described the step of preparing graphene, includes：100mg graphene oxides are taken to be added to the scattered molten of 100mL In liquid, the ultrasonic 5-60min of strength；4-6mmol NaHSO are added under magnetic agitation3, stirring reaction 2-5h at 80-100 DEG C；Filtering After be washed with deionized 3-5 times；Graphene is obtained after product is freeze-dried.
Preferably, the preparation method of the electrostatic spinning liquid includes：By graphene or graphene oxide and P25TiO2Answer Close sterilization material and add ultrasonic 10-60min in dispersion solvent, it is scattered to form uniform suspension；High molecular polymer is added, is surpassed Sound 2-6h, polymer is fully dissolved and is uniformly mixed with composite bactericidal material, form uniform electrostatic spinning liquid.
Preferably, the mass ratio of composite bactericidal material is 0.1%-20% in the electrostatic spinning liquid, high molecular polymer Mass ratio be 5%-25%.
Preferably, the high molecular polymer be polyvinyl alcohol, PVP, in polyacrylamide at least It is a kind of.
Preferably, the dispersion solvent is at least one of water, ethanol, acetone, isopropanol, formic acid.
From the above-mentioned description to structure of the present invention, compared to the prior art, the invention has the advantages that：.
The preparation method of a kind of restraining and sterilizing bacteria adhesive bandage of the present invention and its stenlizing layer, is prepared by electrospinning process and aoxidized Graphene or graphene, TiO2Nanofiber, which is attached on the adhesive tape of adhesive bandage, forms stenlizing layer, due to graphene, TiO2It is scattered Property is good, avoids graphene, TiO2Reunion causes its degradation, allows stenlizing layer to be preferably attached on adhesive tape again, while not The phenomenon that shed powder pollutes occurs.And design of adhesive tape is beneficial to TiO into transparent2Light-catalysed progress, play effectively Restraining and sterilizing bacteria performance, wound infection inflammation is avoided, while graphene has extra specific surface area, adsorption capacity is strong, beneficial to holding Wound surface is dried, and accelerates the healing rate of wound.
Brief description of the drawings
The accompanying drawing for forming the part of the application is used for providing a further understanding of the present invention, schematic reality of the invention Apply example and its illustrate to be used to explain the present invention, do not form inappropriate limitation of the present invention.In the accompanying drawings：
Fig. 1 is the structural representation of restraining and sterilizing bacteria adhesive bandage of the present invention.
Fig. 2 is the flow chart of the preparation method of restraining and sterilizing bacteria adhesive bandage of the present invention.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, it is right below in conjunction with drawings and Examples The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and It is not used in the restriction present invention.
As shown in figure 1, the invention provides a kind of restraining and sterilizing bacteria adhesive bandage, the restraining and sterilizing bacteria adhesive bandage is fitted including length and width Suitable adhesive tape 11, stenlizing layer 12 and diaphragm 13；The adhesive tape 11 is adhesive tape；The restraining and sterilizing bacteria layer 12 is located at adhesive tape 11 middle parts；The stenlizing layer 12 is graphene or graphene oxide and P25TiO2It is combined；Graphene is to human body cell Normal development, metabolism do not have an impact, and bacterium can not grow on graphene, have safely and effectively fungistatic effect；Stone simultaneously Black alkene has huge specific surface area, can absorb the body fluid such as a large amount of tissue secretion things, purulence thing, blood, keeps wound surface to do It is dry, beneficial to wound healing.Nano titanium oxide can not only influence bacterial reproduction power, and can destroy the membrane structure of bacterium, Reach thorough bacterium for degrading, prevent secondary pollution caused by endotoxin, nano titanium oxide belongs to non-dissolving type material, is degrading While organic pollution and killing bacterium, itself is not decomposed, not dissolution, and photocatalysis is lasting, and with lasting sterilization, drop Solve pollutant effect.Titanium dioxide P25 and graphene is compound, and it has more preferable photocatalysis performance, degradation of organic substances ability It will greatly improve.Titanium dioxide is free by that can generate the very strong superoxide anion radical of chemical activity and hydrogen-oxygen during light Base, organic matter is attacked, has the function that degradable organic pollutant.When running into bacterium, the cell of direct attack bacteria, cause thin The intracellular organic matter degradation of bacterium, bacterium is killed with this, and be allowed to decompose.
Wherein, the restraining and sterilizing bacteria adhesive bandage, air-vent 14 is provided with the middle part of adhesive tape 11, avoids wound skin impermeable Gas.Diaphragm 13 is the cover layer at adhesive tape both ends, for protecting the viscosity of adhesive tape 11 and restraining and sterilizing bacteria layer 12.
As shown in Fig. 2 present invention also offers the preparation method of restraining and sterilizing bacteria adhesive bandage, comprise the following steps：
S101, prepare graphene oxide or graphene；
Graphene oxide preparation method includes：
Step 1.1,2g graphite powders are added in flask, 1gNaNO is added under ice-water bath3With the 46mL concentrated sulfuric acids；Step 1.2, 6g KMnO is slowly added under magnetic agitation4, temperature be less than 20 DEG C, react 5-60min after remove ice-water bath；Step 1.3, heating To 30-40 DEG C, 20-60min is reacted, deionized water is slowly added dropwise；60- is added after step 1.4, stirring reaction 10-30min 100mL 3wt% hydrogen peroxide solutions, until the lather collapse in reaction system；Step 1.5, exceed the speed limit under rotating speed 7200rpm from Heart 10-30min, then washed repeatedly with watery hydrochloric acid, distilled water successively, until PH is neutrality, obtain crude product；Step 1.6, incite somebody to action To crude product be dissolved in again in water, ultrasonic 10-30min, filter out not oxidized graphite residue；Step 1.7, obtain oxygen Graphite alkene；
Graphene preparation method includes：
Step 2.1, take 100mg steps 1.7 that graphene oxide is made to be added in 100mL dispersion soln, strength ultrasound 5-60min；4-6mmol NaHSO are added under step 2.1, magnetic agitation3, stirring reaction 2-5h at 80-100 DEG C；Step 2.3, It is washed with deionized 3-5 times after filtering；Step 2.4, obtain graphene after product is freeze-dried；
S102, by graphene or graphene oxide and P25TiO2It is combined into sterilization material；
S103, prepare electrostatic spinning liquid；
The preparation method of the electrostatic spinning liquid includes：By graphene, graphene oxide and P25TiO2Composite bactericidal material Material adds ultrasonic 10-60min in dispersion solvent, scattered to form uniform suspension；Addition high molecular polymer, ultrasonic 2-6h, Polymer is fully dissolved and is uniformly mixed with composite bactericidal material, form uniform electrostatic spinning liquid, the electrostatic spinning liquid The mass ratio of middle composite bactericidal material is 0.1%-20%, and the mass ratio of high molecular polymer is 5%-25%., the macromolecule Polymer is at least one of polyvinyl alcohol, PVP, polyacrylamide, and the dispersion solvent is water, second Alcohol, acetone, isopropanol, formic acid are at least one.
S104, electrostatic spinning formed into stenlizing layer on adhesive tape；
Spinning solution is transferred in the syringe of spinneret, a diameter of 2mm of syringe metal needle, high-voltage power cathode Connecting metal needle, adhesive tape ground connection, the distance of syringe metal needle to adhesive tape is 10cm, flow velocity 0.1mL/h, In the environment of humidity 40%RH, 25 DEG C of temperature, two pole tensions of regulation to 20KV carry out spinning, finally on adhesive tape directly Form stenlizing layer.
Nano titanium oxide can not only influence bacterial reproduction power, and can destroy the membrane structure of bacterium, reach thorough Bacterium for degrading, secondary pollution caused by endotoxin is prevented, play the effect for thoroughly killing bacterium.Therefore by graphene, TiO2With High molecular polymer mixes to form uniform spinning solution, then prepares the nanometer with restraining and sterilizing bacteria function by electrostatic spinning Fiber, it is attached directly on the adhesive tape of adhesive bandage, produces the adhesive bandage with antibiotic and sterilizing function, and sterilization material distribution is equal Even and adhesive force is good, is not in that powder drops and polluted.
Embodiment 1
Graphene oxide made from taking the step S101 that mass ratio is 1%, adds in ethanol and carries out ultrasonic 30min, continues 25% PVA is added, continues ultrasonic 2h, makes PVA and graphene oxide is full and uniform mixes, form uniform spinning solution；It will spin Silk solution is transferred in the syringe of spinneret, a diameter of 2mm of syringe metal needle, high-voltage power cathode connection metal needle Head, adhesive tape ground connection, the distance of syringe metal needle to adhesive tape is 12cm, flow velocity 0.2mL/h, in humidity 50% RH, in the environment of 25 DEG C of temperature, two pole tensions of regulation are finally directly formed antibacterial to 15KV progress spinning on adhesive tape Layer.
Embodiment 2
Graphene made from taking the step S101 that mass ratio is 5%, adds in ethanol and carries out ultrasonic 30min, continuously add 25% PVP, continue ultrasonic 2h, make PVP and graphene oxide is full and uniform mixes, Form uniform spinning solution；Spinning solution is transferred in the syringe of spinneret, a diameter of 2mm of syringe metal needle, it is high Voltage source positive pole connects metal needle, adhesive tape ground connection, and the distance of syringe metal needle to adhesive tape is 12cm, flow velocity For 0.2mL/h, in the environment of humidity 50%RH, 25 DEG C of temperature, two pole tensions of regulation to 15KV carry out spinning, finally transparent Antibacterial layer is directly formed on adhesive tape.
Embodiment 3
Graphene oxide and titanium dioxide P25 made from taking the step S101 that mass ratio is 5%, add in acetone and are surpassed Sound 40min, continuously add 20% PVP, ultrasonic 3h；Make PVP and graphene oxide, The full and uniform mixing of titanium dioxide P25, forms uniform spinning solution；Spinning solution is transferred in the syringe of spinneret, noted The a diameter of 4mm of emitter metal needle, high-voltage power cathode connection metal needle, adhesive tape ground connection, syringe metal needle arrive The distance of adhesive tape is 15cm, flow velocity 0.3mL/h, in the environment of humidity 45%RH, 25 DEG C of temperature, adjusts two pole tensions Spinning is carried out to 20KV, is finally directly formed on adhesive tape and antibacterial kills layer.
Adhesive bandage made from above example is applied to the wound of same patient together with common adhesive bandage on the market On, contrast its wound healing situation.For the new wound of no infection, more than use adhesive bandage, wound made from 4 embodiments Healed completely in 2-3 days, and infection inflammation phenomenon do not occur, and using common adhesive bandage, wound typically exist on the market Heal, and have and infection phenomenons occur individually within 3-7 days；And for there is the old wound of mild infection, using embodiment 1 and implement Adhesive bandage made from example 3, infection phenomenons fade away in 1 day, and are healed completely in 2-3 days, use embodiment 2 and embodiment Adhesive bandage made from 3, wound infection phenomenon is eased, and is healed completely in 2-5 days；And using common wound can on the market Patch, wound infection phenomenon are not alleviated, and wound is difficult to heal for a long time.
For embodiment 1 and 3 because adding titanium dioxide P25 on adhesive bandage restraining and sterilizing bacteria layer, it has the function of sterilization, Therefore when it acts on the old wound for occurring infecting, bacterium can be killed in time and allows wound infection phenomenon to disappear, accelerates wound healing Speed.And for the new wound of no infection, as long as adding graphene or graphene oxide with regard to the growth of bacterium can be suppressed, no Infection phenomenons occur, keeps wound surface to dry, wound is faster healed.
The present invention can effectively play restraining and sterilizing bacteria performance in summary, avoid wound infection inflammation, while graphene has Extra specific surface area, adsorption capacity is strong, beneficial to keeping wound surface to dry, can accelerate the healing rate of wound.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention All any modification, equivalent and improvement made within refreshing and principle etc., should be included in the scope of the protection.

Claims (10)

  1. A kind of 1. restraining and sterilizing bacteria adhesive bandage, it is characterised in that：The restraining and sterilizing bacteria adhesive bandage includes：Adhesive tape, it is located in the middle part of adhesive tape Stenlizing layer and be located on adhesive tape and cover the diaphragm of stenlizing layer, the stenlizing layer be graphene or graphene oxide and P25TiO2It is combined.
  2. A kind of 2. restraining and sterilizing bacteria adhesive bandage according to claim 1, it is characterised in that：The adhesive tape is adhesive tape, institute State stenlizing layer and be located at adhesive tape middle part, the diaphragm is the cover layer at adhesive tape both ends.
  3. A kind of 3. restraining and sterilizing bacteria adhesive bandage according to claim 1, it is characterised in that：The adhesive tape middle part is additionally provided with Air-vent.
  4. 4. a kind of preparation method of restraining and sterilizing bacteria adhesive bandage, it is characterised in that comprise the following steps：
    Prepare graphene oxide or graphene；
    By graphene oxide or graphene and P25TiO2It is combined into sterilization material；
    Prepare electrostatic spinning liquid；
    Electrostatic spinning liquid is formed into stenlizing layer on adhesive tape.
  5. 5. the preparation method of restraining and sterilizing bacteria adhesive bandage according to claim 4, it is characterised in that：It is described to prepare graphite oxide The step of alkene, includes：2g graphite powders are added in flask, 1g NaNO are added under ice-water bath3With the 46mL concentrated sulfuric acids；Under magnetic agitation It is slowly added to 6g KMnO4, temperature be less than 20 DEG C, react 5-60min after remove ice-water bath；30-40 DEG C is warming up to, reacts 20- 60min, deionized water is slowly added dropwise；60-100mL 3wt% hydrogen peroxide solutions are added after stirring reaction 10-30min, until Lather collapse in reaction system；The ultracentrifugation 10-30min under rotating speed 7200rpm, then it is anti-with watery hydrochloric acid, distilled water successively After backwashing is washed, until PH for neutrality, obtain crude product；Obtained crude product is dissolved in water again, ultrasonic 10-30min, filtered out Not oxidized graphite residue；Obtain graphene oxide.
  6. 6. the preparation method of restraining and sterilizing bacteria adhesive bandage according to claim 4, it is characterised in that：The graphene of preparing Step includes：100mg graphene oxides are taken to be added in 100mL dispersion soln, the ultrasonic 5-60min of strength；Under magnetic agitation Add 4-6mmol NaHSO3, stirring reaction 2-5h at 80-100 DEG C；It is washed with deionized 3-5 times after filtering；Product is cold It is lyophilized it is dry after obtain graphene.
  7. 7. the preparation method of restraining and sterilizing bacteria adhesive bandage according to claim 4, it is characterised in that：The electrostatic spinning liquid Preparation method includes：By graphene or graphene oxide and P25TiO2Composite bactericidal material add dispersion solvent in ultrasonic 10- 60min, it is scattered to form uniform suspension；Add high molecular polymer, ultrasonic 2-6h, make polymer fully dissolve and with it is compound Sterilization material uniformly mixes, and forms uniform electrostatic spinning liquid.
  8. 8. the preparation method of restraining and sterilizing bacteria adhesive bandage according to claim 7, it is characterised in that：In the electrostatic spinning liquid The mass ratio of composite bactericidal material is 0.1%-20%, and the mass ratio of high molecular polymer is 5%-25%.
  9. 9. the preparation method of restraining and sterilizing bacteria adhesive bandage according to claim 7, it is characterised in that：The high molecular polymer For at least one of polyvinyl alcohol, PVP, polyacrylamide.
  10. 10. the preparation method of restraining and sterilizing bacteria adhesive bandage according to claim 7, it is characterised in that：The dispersion solvent is At least one of water, ethanol, acetone, isopropanol, formic acid.
CN201610622593.4A 2016-08-01 2016-08-01 A kind of restraining and sterilizing bacteria adhesive bandage and preparation method thereof Pending CN107670088A (en)

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN108113979A (en) * 2018-03-02 2018-06-05 江西金思康药业有限公司 A kind of Eradicates pains patch
CN108339144A (en) * 2018-03-28 2018-07-31 广西中医药大学 Adhesive bandage and its preparation method and application

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