CN105288602A - 具有γ干扰素的抗原呈递癌症疫苗 - Google Patents

具有γ干扰素的抗原呈递癌症疫苗 Download PDF

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Publication number
CN105288602A
CN105288602A CN201510706438.6A CN201510706438A CN105288602A CN 105288602 A CN105288602 A CN 105288602A CN 201510706438 A CN201510706438 A CN 201510706438A CN 105288602 A CN105288602 A CN 105288602A
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China
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cell
melanoma
ifn
autophagy
apoptosis
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Pending
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CN201510706438.6A
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English (en)
Chinese (zh)
Inventor
安德鲁.康福思
罗伯特.迪尔曼
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NeoStem Oncology LLC
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California Stem Cells Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13Tumour cells, irrespective of tissue of origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/19Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24Antigen-presenting cells [APC]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4271Melanoma antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/80Vaccine for a specifically defined cancer
    • A61K2039/876Skin, melanoma
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/30Coculture with; Conditioned medium produced by tumour cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201510706438.6A 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗 Pending CN105288602A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161549681P 2011-10-20 2011-10-20
US61/549681 2011-10-20
US201261594304P 2012-02-02 2012-02-02
US61/594304 2012-02-02
CN201280051821.7A CN103957925A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280051821.7A Division CN103957925A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗

Publications (1)

Publication Number Publication Date
CN105288602A true CN105288602A (zh) 2016-02-03

Family

ID=48141460

Family Applications (5)

Application Number Title Priority Date Filing Date
CN201510706438.6A Pending CN105288602A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗
CN201610218244.6A Withdrawn CN105861437A (zh) 2011-10-20 2012-10-22 抗原呈递癌症疫苗
CN201610301904.7A Pending CN105999249A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗
CN201280051799.6A Pending CN103917246A (zh) 2011-10-20 2012-10-22 抗原呈递癌症疫苗
CN201280051821.7A Pending CN103957925A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗

Family Applications After (4)

Application Number Title Priority Date Filing Date
CN201610218244.6A Withdrawn CN105861437A (zh) 2011-10-20 2012-10-22 抗原呈递癌症疫苗
CN201610301904.7A Pending CN105999249A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗
CN201280051799.6A Pending CN103917246A (zh) 2011-10-20 2012-10-22 抗原呈递癌症疫苗
CN201280051821.7A Pending CN103957925A (zh) 2011-10-20 2012-10-22 具有γ干扰素的抗原呈递癌症疫苗

Country Status (11)

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US (2) US9555058B2 (enExample)
EP (2) EP2768519A4 (enExample)
JP (2) JP2014530627A (enExample)
KR (2) KR20150016200A (enExample)
CN (5) CN105288602A (enExample)
AU (2) AU2012325764A1 (enExample)
CA (2) CA2852960A1 (enExample)
HK (2) HK1201176A1 (enExample)
IL (2) IL232173A0 (enExample)
SG (4) SG11201401631VA (enExample)
WO (2) WO2013059784A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118441033A (zh) * 2024-04-24 2024-08-06 广西医科大学 HLA-DPB1*05:01在抗γ干扰素自身抗体所致获得性免疫缺陷筛查中的应用

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FR2865830B1 (fr) 2004-01-30 2006-05-19 Neopost Ind Systeme d'affranchissement de courrier a mode d'impression externe securise
CN105288602A (zh) 2011-10-20 2016-02-03 新干细胞肿瘤学有限责任公司 具有γ干扰素的抗原呈递癌症疫苗
CN103599528B (zh) * 2013-12-04 2015-08-05 深圳市合一康生物科技股份有限公司 人树突状细胞疫苗的制备方法
JP6967963B2 (ja) * 2014-07-17 2021-11-17 ブライアン ジェイ ツェルニキCZERNIECKI, Brian, J. 複数用量注射準備済樹状細胞ワクチンの製造ならびにher2およびher3を遮断するための併用療法
KR20180126085A (ko) * 2016-05-05 2018-11-26 난토믹스, 엘엘씨 체크포인트 부전 및 그 방법(checkpoint failure and methods therefor)
CA3053939A1 (en) * 2017-02-17 2018-08-23 Aivita Biomedical, Inc. Methods to enhance tumor immunogenicity and compositions for autologous cancer immunotherapeutic products using modified tumor cells and modified dendritic cells
WO2024107624A1 (en) * 2022-11-14 2024-05-23 Shattuck Labs, Inc. Methods of overcoming resistance to checkpoint inhibitor therapies

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US20080031900A1 (en) * 2006-06-30 2008-02-07 Baylor Research Institute Dendritic Cells Generated Using GM-CSF and Interferon Alpha and Loaded with Heat-Treated and Killed Cancer Cells
US20090041792A1 (en) * 2007-07-19 2009-02-12 Istituto Superiore Di Sanita Dendritic cells, uses therefor, and vaccines and methods comprising the same

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118441033A (zh) * 2024-04-24 2024-08-06 广西医科大学 HLA-DPB1*05:01在抗γ干扰素自身抗体所致获得性免疫缺陷筛查中的应用

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Publication number Publication date
IL232173A0 (en) 2014-06-30
NZ623917A (en) 2016-09-30
SG11201401631VA (en) 2014-05-29
WO2013059778A3 (en) 2013-07-04
EP2768534A4 (en) 2015-04-01
KR20150004791A (ko) 2015-01-13
EP2768534A1 (en) 2014-08-27
JP2014530627A (ja) 2014-11-20
JP2014533938A (ja) 2014-12-18
HK1201175A1 (en) 2015-08-28
NZ623915A (en) 2016-02-26
SG10201602424RA (en) 2016-05-30
EP2768519A2 (en) 2014-08-27
WO2013059784A1 (en) 2013-04-25
SG10201508535RA (en) 2015-11-27
US9555058B2 (en) 2017-01-31
SG11201401632WA (en) 2014-05-29
CA2852960A1 (en) 2013-04-25
CN103917246A (zh) 2014-07-09
US20140308316A1 (en) 2014-10-16
CN103957925A (zh) 2014-07-30
CN105861437A (zh) 2016-08-17
CA2852967A1 (en) 2013-04-25
EP2768519A4 (en) 2015-07-01
WO2013059778A2 (en) 2013-04-25
CN105999249A (zh) 2016-10-12
HK1201176A1 (en) 2015-08-28
IL232172A0 (en) 2014-06-30
AU2012325758A1 (en) 2014-04-24
KR20150016200A (ko) 2015-02-11
US20140314814A1 (en) 2014-10-23
AU2012325764A1 (en) 2014-04-24

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Application publication date: 20160203