CN105288500A - Method for preparing folium artemisiae argyi-contained traditional Chinese medicine composition having analgesic efficacy - Google Patents
Method for preparing folium artemisiae argyi-contained traditional Chinese medicine composition having analgesic efficacy Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, relating to a method for preparing a folium artemisiae argyi-contained traditional Chinese medicine composition having analgesic efficacy. The method comprises the steps of weighing the folium artemisiae argyi, synurus deltoids, clematis filamentosa dunn, ligusticum wallichii, curcuma zedoary, rhizoma sparganii, the root of red-rooted salvia, galangal, rhizoma corydalis, radix aucklandiae, longstamen onion bulb, semen litchi and radix glycyrrhizae, respectively smashing, sieving, mixing, soaking, decocting, filtering and concentrating to obtain the traditional Chinese medicine composition provided by the invention. The method is simple and convenient, easy to implement, stable in efficacy of a preparation, good in universality and liable to promote and use. The prepared traditional Chinese medicine composition has the technical advantages of being quick in result and good in effect, treating both symptoms and root causes, recuperating under medical treatment and the like in analgesia, particularly has a remarkable analgesic effect on pain caused by blood stasis and blocking, and invading of cold-dampness.
Description
Technical field
The present invention relates to a kind of method with the Chinese medicine composition of analgesic efficacy prepared containing Folium Artemisiae Argyi, belong to technical field of Chinese medicines.
Background technology
In life, traumatic injury collides with unavoidable, easily causes body local subcutaneous soft tissue contusion, tears, hemorrhage or ooze out, thus causes injury pain and swelling hemorrhage, and its cause of disease of tcm diagnosis is that congestion is stopped up stagnant, and blood is held one's breath resistance.Doctor trained in Western medicine adopts antiinflammatory, analgesic to treat usually clinically, but these medicines are cured the symptoms, not the disease, and stops blooding in a short time, analgesic effect is obvious, but duration of efficacy is short and have certain side effect, and Reusability easily forms drug dependence.Chinese traditional treatment disease is according to there being the advantage such as treating both the principal and secondary aspects of a disease, medical treatment combination, and drug side effect is low, according to there being significant advantage in disease therapy.Exterior-applied formulation can directly act on affected part, avoids gastrointestinal tract barrier, targetedly from treating the disease such as traumatic injury, local pain caused by ecchymoma, muscle tendon soft tissue injury and osteoarthritis at all.
Chinese patent application 201110455696.3 discloses a kind of traditional Chinese medicinal composition for blood circulation invigorating, be made up of the crude drug of following weight portion: Radix Rehmanniae Preparata 28-32 part, Caulis Spatholobi 12-18 part, Radix Angelicae Sinensis 8-12 part, Huaihe River cattle sunset 8-12 part, Radix Glycyrrhizae 4-6 part, Herba Epimedii 8-2 part, Radix Dipsaci 12-18 part, Olibanum (processed) 4-6 part, Fructus Psoraleae 8-12 part, Herba Cistanches 8-12 part, Rhizoma Corydalis 8-12 part, Cortex Eucommiae 12-18 part, Radix Pseudostellariae 18-22 part, Borneolum Syntheticum 3-5 part, Eupolyphaga Seu Steleophaga 4-12 part, this Chinese medicine composition is according to there being nourshing blood and promoting blood circulation, the effect of the strong muscle of the kidney invigorating, be used for the treatment of caused by liver and kidney deficiency, the diseases such as chronic lumbar muscle strain caused by deficient qi and blood are evident in efficacy, but stop up stagnant for congestion, blood is held one's breath and is hindered the pain that causes, analgesic effect is not good.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition with analgesic efficacy containing Folium Artemisiae Argyi, and uses modern pharmaceutical technology that this Chinese medicine is made the required finished product preparation of modern clinic.
In order to solve the problems of the technologies described above, inventor is according to the feature of modern pharmaceutical technology and tcm clinical practice experience for many years, and its years of researches in pain relieving, meticulous compatibility medical material, deal and the kind of crude drug repeatedly adjusted, increase and decrease by practice, the Chinese prescription that final invention one is brand-new, comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 23-30 part, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21-29 part, Clematis filamentosa Dunn 17-25 part, Rhizoma Chuanxiong 18-28 part, Rhizoma Curcumae 16-21 part, Rhizoma Sparganii 16-21 part, Radix Salviae Miltiorrhizae 10-15 part, Rhizoma Alpiniae Officinarum 14-18 part, Rhizoma Corydalis 11-17 part, Radix Aucklandiae 10-15 part, Bulbus Allii Macrostemonis 12-18 part, Semen Litchi 13-19 part and Radix Glycyrrhizae 6-13 part.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 23 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21 parts, Clematis filamentosa Dunn 17 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Curcumae 16 parts, Rhizoma Sparganii 16 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Alpiniae Officinarum 14 parts, Rhizoma Corydalis 11 parts, the Radix Aucklandiae 10 parts, Bulbus Allii Macrostemonis 12 parts, Semen Litchi 13 parts and 6 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 29 parts, Clematis filamentosa Dunn 25 parts, Rhizoma Chuanxiong 28 parts, Rhizoma Curcumae 21 parts, Rhizoma Sparganii 21 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Alpiniae Officinarum 18 parts, Rhizoma Corydalis 17 parts, the Radix Aucklandiae 15 parts, Bulbus Allii Macrostemonis 18 parts, Semen Litchi 19 parts and 13 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 27 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 25 parts, Clematis filamentosa Dunn 21 parts, Rhizoma Chuanxiong 23 parts, Rhizoma Curcumae 19 parts, Rhizoma Sparganii 19 parts, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Alpiniae Officinarum 15 parts, Rhizoma Corydalis 13 parts, the Radix Aucklandiae 14 parts, Bulbus Allii Macrostemonis 15 parts, Semen Litchi 14 parts and 9 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 26 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 26 parts, Clematis filamentosa Dunn 20 parts, Rhizoma Chuanxiong 24 parts, Rhizoma Curcumae 18 parts, Rhizoma Sparganii 18 parts, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Alpiniae Officinarum 16 parts, Rhizoma Corydalis 14 parts, the Radix Aucklandiae 13 parts, Bulbus Allii Macrostemonis 16 parts, Semen Litchi 16 parts and 10 parts, Radix Glycyrrhizae.
The present invention discloses a kind of method with the Chinese medicine composition of analgesic efficacy prepared containing Folium Artemisiae Argyi, comprise the following steps: by Folium Artemisiae Argyi, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), Clematis filamentosa Dunn, Rhizoma Chuanxiong, Rhizoma Curcumae, Rhizoma Sparganii, Radix Salviae Miltiorrhizae, Rhizoma Alpiniae Officinarum, Rhizoma Corydalis, the Radix Aucklandiae, Bulbus Allii Macrostemonis, Semen Litchi, Radix Glycyrrhizae, pulverize respectively, cross 20 mesh sieves, the distilled water of 7-11 times of medical material gross weight is added after mixing, soak 6-12 hour, decoct 2-3 time, each 2-5 hour, filter, merging filtrate to be concentrated into 55-60 DEG C of relative density be the concentrated solution of 1.20-1.25, obtains Chinese medicine composition of the present invention.
Preferably, the dosage form of described Chinese medicine composition is exterior-applied formulation.
Preferably, the exterior-applied formulation of described Chinese medicine composition is ointment, ointment, spray or liniment.
The present invention also discloses a kind of purposes of the Chinese medicine composition with analgesic efficacy in pain relieving containing Folium Artemisiae Argyi.
The character feature of Chinese medicine composition of the present invention Chinese crude drug used:
Folium Artemisiae Argyi: the dried leaves of this product feverfew Chinese mugwort.Acrid in the mouth, hardship, warm in nature; Return liver,spleen,kidney warp; Dispersing cold for relieving pain, warming the meridian for stopping bleeding.
Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae): this product is that Compositae Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) is used as medicine with root.Acrid in the mouth, warm in nature; GUIXIN, spleen, kidney channel; Cold relieving, dissipating blood stasis, analgesia.
Clematis filamentosa Dunn: this product is the leaf of Ranunculaceae Clematis filamentosa Dunn.Sweet in the mouth, slightly cool in nature, cold nature; Return liver, heart channel; Clearing away liver-fire; Mind calming god; Blood pressure lowering; Removing obstruction in the collateral to relieve pain.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
Rhizoma Curcumae: this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE; Acrid in the mouth, hardship, warm in nature; Return liver, spleen channel; Circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.
Rhizoma Sparganii: the dry tuber of this product to be this product be Sparganiaceae plant rhizoma scirpi.Bitter in the mouth, pungent, property is put down; Return liver, spleen channel; Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae; Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Rhizoma Alpiniae Officinarum: this product is the dry rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum.Acrid in the mouth, hot in nature; Return spleen, stomach warp; Warming stomach for dispelling cold, help digestion pain relieving.
Rhizoma Corydalis: this product is the dry tuber of papaveraceae plant corydalis.Acrid in the mouth is bitter, warm in nature; Return liver, spleen channel; Blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae.Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
Bulbus Allii Macrostemonis: this product is the dry bulb of liliaceous plant Allium macrostemon or Chinese onion.Bitter in the mouth, pungent, warm in nature; Return stomach, lung, large intestine channel; Activating YANG and eliminating stagnation, circulation of qi promoting intestinal stasis relieving.
Semen Litchi: this product is the dry mature seed of sapindaceous plant Fructus Litchi.Sweet in the mouth, micro-hardship, warm in nature; Return liver, kidney channel; Promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is with Folium Artemisiae Argyi, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) for monarch drug, dispersing cold for relieving pain, warming the meridian for stopping bleeding; With Clematis filamentosa Dunn, Rhizoma Chuanxiong, Rhizoma Curcumae and Rhizoma Sparganii for ministerial drug, removing obstruction in the collateral to relieve pain, promoting blood circulation to remove obstruction in the collateral, removing food stagnancy pain relieving; With Radix Salviae Miltiorrhizae, Rhizoma Alpiniae Officinarum, Rhizoma Corydalis, the Radix Aucklandiae, Bulbus Allii Macrostemonis and Semen Litchi for adjuvant drug, hard masses softening and resolving pain relieving, soothing the channels and quicking the network vessels; With Radix Glycyrrhizae for making medicine, coordinating the actions of various ingredients in a prescription, makes all medicines arrange in pairs or groups, synergism, plays effect of promoting blood circulation to remove obstruction in the collateral, expelling wind and removing dampness, detumescence dismission, pain relieving of inducing sweat altogether, has significant analgesic effect.
Pharmacodynamic experiment shows that Chinese medicine composition of the present invention is in pain relieving, antiinflammatory and removing blood stasis to reduce swelling, has significant curative effect.For traumatic injury, the local swelling pain that causes of pain caused by ecchymoma, muscle tendon soft tissue injury and osteoarthritis belongs to blood stasis retardance, cold-damp invading in the interior person has instant effect, effective, treating both the principal and secondary aspects of a disease, medical treatment combine, the not easily technical advantage such as recurrence, especially for cureless pain, there is therapeutic effect significantly, further, Chinese medicinal composition preparation efficacy stability of the present invention, universality good, be easy to apply.
Detailed description of the invention
Embodiment 1
The embodiment of the present invention 1 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 23 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21 parts, Clematis filamentosa Dunn 17 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Curcumae 16 parts, Rhizoma Sparganii 16 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Alpiniae Officinarum 14 parts, Rhizoma Corydalis 11 parts, the Radix Aucklandiae 10 parts, Bulbus Allii Macrostemonis 12 parts, Semen Litchi 13 parts and 6 parts, Radix Glycyrrhizae.
Preparation method:
(1) by Folium Artemisiae Argyi, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae), Clematis filamentosa Dunn, Rhizoma Chuanxiong, Rhizoma Curcumae, Rhizoma Sparganii, Radix Salviae Miltiorrhizae, Rhizoma Alpiniae Officinarum, Rhizoma Corydalis, the Radix Aucklandiae, Bulbus Allii Macrostemonis, Semen Litchi, Radix Glycyrrhizae, pulverize respectively, cross 20 mesh sieves, add the distilled water of 9 times of medical material gross weights after mixing, soak 6 hours, decoct 2 times, each 3 hours, filter, merging filtrate to be concentrated into 55-60 DEG C of relative density be the concentrated solution of 1.20, obtain Chinese medicine composition of the present invention;
(2) add adjuvant, Chinese medicine composition of the present invention is made ointment, amounts to crude drug content 0.55 crude drug/g ointment.
Embodiment 2
The embodiment of the present invention 2 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 30 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 29 parts, Clematis filamentosa Dunn 25 parts, Rhizoma Chuanxiong 28 parts, Rhizoma Curcumae 21 parts, Rhizoma Sparganii 21 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Alpiniae Officinarum 18 parts, Rhizoma Corydalis 17 parts, the Radix Aucklandiae 15 parts, Bulbus Allii Macrostemonis 18 parts, Semen Litchi 19 parts and 13 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 3
The embodiment of the present invention 3 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 27 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 25 parts, Clematis filamentosa Dunn 21 parts, Rhizoma Chuanxiong 23 parts, Rhizoma Curcumae 19 parts, Rhizoma Sparganii 19 parts, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Alpiniae Officinarum 15 parts, Rhizoma Corydalis 13 parts, the Radix Aucklandiae 14 parts, Bulbus Allii Macrostemonis 15 parts, Semen Litchi 14 parts and 9 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Embodiment 4
The embodiment of the present invention 4 Chinese medicine composition comprises the raw materials of following parts by weight:
Folium Artemisiae Argyi 26 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 26 parts, Clematis filamentosa Dunn 20 parts, Rhizoma Chuanxiong 24 parts, Rhizoma Curcumae 18 parts, Rhizoma Sparganii 18 parts, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Alpiniae Officinarum 16 parts, Rhizoma Corydalis 14 parts, the Radix Aucklandiae 13 parts, Bulbus Allii Macrostemonis 16 parts, Semen Litchi 16 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
Test example 1: the pharmacodynamics test of Chinese medicine composition of the present invention
1, test drug: 0.55 crude drug obtained by embodiment of the present invention 1-4/g ointment.Positive control drug is bone-setting liquor (the accurate word Z45021659 of traditional Chinese medicines, Guangxi Yulin Pharmaceutical Group Co., Ltd.), dexamethasone (the accurate word H20060241 of traditional Chinese medicines, Golden Sun Pharmaceutical (China) Co., Ltd.).
2, animal used is tested: regular grade NIH mice, body weight 24g ± 3g.
3, test method:
(1) analgesic experiment
Get healthy mice 80, male, be divided into 8 groups, often organize 10, i.e. the embodiment of the present invention 3, embodiment 4 Chinese medicine composition high dose group, middle dosage group and low dose group, positive controls, model control group.Drug test group trial drug of the present invention is the embodiment of the present invention 3, the ointment that embodiment 4 is obtained, dosage is high dose group (4.2g/kg), middle dosage group (2.8g/kg) and low dose group (1.4g/kg), positive control drug is bone-setting liquor (the accurate word Z45021659 of traditional Chinese medicines, Guangxi Yulin Pharmaceutical Group Co., Ltd.), dosage is 4.2g/kg, model control group is coated with the bare substrate of the embodiment of the present invention 3 ointment of equivalent, mouse abdominal part loses hair or feathers with 8% sodium sulfide the previous day by administration, according to dosage be coated with corresponding medicine 1 time every day, continuous three days, fasting 12h before the administration of mice last, after last administration 1h, each group of mouse peritoneal only injects 0.7% acetic acid normal saline solution 0.2ml/, the writhing number of times of each mice in observed and recorded 20 minutes, respectively organize difference, the results are shown in Table 1.
The impact (n=10) of table 1 acetic acid induced mice pain (
± SD)
Note: compare with model control group, drug test group
*p < 0.05,
*p < 0.01, compares with positive controls, Chinese medicine composition drug test group of the present invention
#p < 0.05,
##p < 0.01.
Result shows, compared with model control group, drug test group all significantly can reduce mice pain twisting number of times, illustrate that drug test group all has significant analgesic effect to mice acetic acid is pain caused, and the relieving pain of the middle and high dosage group of Chinese medicine composition of the present invention is better than positive controls.
Test example 2: the impact test of Chinese medicine composition Dichlorodiphenyl Acetate induced mice abdominal cavity of the present invention capillary permeability
Get NIH mice 80, male and female half and half, be divided into 8 groups at random, often organize 10, i.e. the embodiment of the present invention 3, embodiment 4 Chinese medicine composition high dose group, middle dosage group and low dose group, positive controls, model control group.Drug test group trial drug of the present invention is the embodiment of the present invention 3, the ointment that embodiment 4 is obtained, dosage is high dose group (4.2g/kg), middle dosage group (2.8g/kg) and low dose group (1.4g/kg), positive control drug is Compound Dexamethasone gel (the accurate word H20060241 of traditional Chinese medicines, Golden Sun Pharmaceutical (China) Co., Ltd.), dosage is 1.4g/kg, model control group is coated with the bare substrate of the embodiment of the present invention 3 ointment of equivalent, mouse abdominal part loses hair or feathers with 8% sodium sulfide the previous day by administration, according to dosage be coated with corresponding medicine 1 time every day, continuous three days, fasting 12h before the administration of mice last, after last administration 1h, each tail vein injection 2% Evans blue normal saline 0.1ml/10g, after injection, lumbar injection 0.7% acetic acid normal saline solution 0.2ml/ is only immediately, mice is put to death after 20 minutes, cut abdominal cavity open, with 5ml normal saline flushing several, collect washing liquid, centrifugal, get supernatant and survey OD value at spectrophotometer 590nm place, more each group difference, the results are shown in Table 2.
The impact (n=10) of table 2 Chinese medicine composition Dichlorodiphenyl Acetate induced mice of the present invention abdominal cavity capillary permeability (
± SD)
Note: compare with model control group, drug test group
*p < 0.01.
Result shows, and each dosage group of Chinese medicine composition of the present invention all can significantly suppress acetic acid induced mice capillary permeability to increase, and its effect is suitable with positive control drug Compound Dexamethasone, illustrates that Chinese medicine composition of the present invention has significant antiphlogistic effects.
Test example 3: removing blood stasis to reduce swelling is tested
Get NIH mice 80, male and female half and half, be divided into 8 groups at random, often organize 10, i.e. the embodiment of the present invention 3, embodiment 4 Chinese medicine composition high dose group, middle dosage group and low dose group, positive controls, model control group.The ointment that drug test group trial drug of the present invention is the embodiment of the present invention 3, embodiment 4 obtains, dosage is high dose group (4.2g/kg), middle dosage group (2.8g/kg) and low dose group (1.4g/kg), positive drug is bone-setting liquor (traditional Chinese medicines Zhun Zi Z45021659 Guangxi Yulin Pharmaceutical Group Co., Ltd.), dosage is 4.2g/kg, and model control group is coated with the bare substrate of the embodiment of the present invention 3 ointment of equivalent.Each group of mice modeling as follows: mouse back is lost hair or feathers 2cm × 3cm with 8% sodium sulfide, within 1 day, posterior orbit gets blood 0.4ml, with 50u/ml heparin-saline 0.1ml anticoagulant, and subcutaneous injection back depilation place, form subcutaneous ecchymosis, measure ecchymosis area after 4h as ecchymosis area before administration.Relative medicine is according to dosage applied to ecchymosis place by each group of mice, every day twice, and measures ecchymosis area every day, until ecchymosis disappears.Relatively first day, the ecchymosis area of second day, the 3rd day, the results are shown in Table 3.
Table 3 Chinese medicine composition removing blood stasis to reduce swelling of the present invention result of the test
Note: compare with model control group, drug test group
*p < 0.05,
*p < 0.01, compares with positive controls, Chinese medicine composition drug test group of the present invention
#p < 0.05.
Mice removing blood stasis to reduce swelling experimental result shows, and each dosage group of Chinese medicine composition of the present invention all can significantly reduce ecchymosis area and reduce ecchymosis extinction time, and the Be very effective of high dose group removing blood stasis to reduce swelling is better than positive controls.
More than experiment shows, the Chinese medicine composition with analgesic efficacy that the present invention contains Folium Artemisiae Argyi has significant analgesic activity, and also have significant antiinflammatory simultaneously and improve microcirculatory effect, removing blood stasis to reduce swelling is evident in efficacy.
Claims (7)
1. prepare the method with the Chinese medicine composition of analgesic efficacy containing Folium Artemisiae Argyi, it is characterized in that, comprise the following steps:
Take Folium Artemisiae Argyi 23-30 part, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21-29 part, Clematis filamentosa Dunn 17-25 part, Rhizoma Chuanxiong 18-28 part, Rhizoma Curcumae 16-21 part, Rhizoma Sparganii 16-21 part, Radix Salviae Miltiorrhizae 10-15 part, Rhizoma Alpiniae Officinarum 14-18 part, Rhizoma Corydalis 11-17 part, Radix Aucklandiae 10-15 part, Bulbus Allii Macrostemonis 12-18 part, Semen Litchi 13-19 part and Radix Glycyrrhizae 6-13 part, pulverize respectively, cross 20 mesh sieves, the distilled water of 7-11 times of medical material gross weight is added after mixing, soak 6-12 hour, decoct 2-3 time, each 2-5 hour, filter, merging filtrate to be concentrated into 55-60 DEG C of relative density be the concentrated solution of 1.20-1.25, obtain Chinese medicine composition of the present invention.
2. preparation according to claim 1 contains the method with the Chinese medicine composition of analgesic efficacy of Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 23 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 21 parts, Clematis filamentosa Dunn 17 parts, Rhizoma Chuanxiong 18 parts, Rhizoma Curcumae 16 parts, Rhizoma Sparganii 16 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Alpiniae Officinarum 14 parts, Rhizoma Corydalis 11 parts, the Radix Aucklandiae 10 parts, Bulbus Allii Macrostemonis 12 parts, Semen Litchi 13 parts and 6 parts, Radix Glycyrrhizae.
3. preparation according to claim 1 contains the method with the Chinese medicine composition of analgesic efficacy of Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 30 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 29 parts, Clematis filamentosa Dunn 25 parts, Rhizoma Chuanxiong 28 parts, Rhizoma Curcumae 21 parts, Rhizoma Sparganii 21 parts, Radix Salviae Miltiorrhizae 15 parts, Rhizoma Alpiniae Officinarum 18 parts, Rhizoma Corydalis 17 parts, the Radix Aucklandiae 15 parts, Bulbus Allii Macrostemonis 18 parts, Semen Litchi 19 parts and 13 parts, Radix Glycyrrhizae.
4. preparation according to claim 1 contains the method with the Chinese medicine composition of analgesic efficacy of Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 27 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 25 parts, Clematis filamentosa Dunn 21 parts, Rhizoma Chuanxiong 23 parts, Rhizoma Curcumae 19 parts, Rhizoma Sparganii 19 parts, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Alpiniae Officinarum 15 parts, Rhizoma Corydalis 13 parts, the Radix Aucklandiae 14 parts, Bulbus Allii Macrostemonis 15 parts, Semen Litchi 14 parts and 9 parts, Radix Glycyrrhizae.
5. preparation according to claim 1 contains the method with the Chinese medicine composition of analgesic efficacy of Folium Artemisiae Argyi, it is characterized in that, described Chinese medicine composition comprises the raw materials of following parts by weight: Folium Artemisiae Argyi 26 parts, Herba seu Radix Cirsii Japonici (Radix Saussureae cordifoliae) 26 parts, Clematis filamentosa Dunn 20 parts, Rhizoma Chuanxiong 24 parts, Rhizoma Curcumae 18 parts, Rhizoma Sparganii 18 parts, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Alpiniae Officinarum 16 parts, Rhizoma Corydalis 14 parts, the Radix Aucklandiae 13 parts, Bulbus Allii Macrostemonis 16 parts, Semen Litchi 16 parts and 10 parts, Radix Glycyrrhizae.
6. preparation according to claim 1 contains the method with the Chinese medicine composition of analgesic efficacy of Folium Artemisiae Argyi, it is characterized in that: the dosage form of described Chinese medicine composition is exterior-applied formulation.
7. preparation according to claim 6 contains the method with the Chinese medicine composition of analgesic efficacy of Folium Artemisiae Argyi, it is characterized in that: the exterior-applied formulation of described Chinese medicine composition is ointment, ointment, spray or liniment.
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| CN101366935A (en) * | 2008-09-22 | 2009-02-18 | 青岛市市立医院 | Externally used ultramicro powder traditional Chinese medicine preparation for treating soft tissue injury and preparation method thereof |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101366935A (en) * | 2008-09-22 | 2009-02-18 | 青岛市市立医院 | Externally used ultramicro powder traditional Chinese medicine preparation for treating soft tissue injury and preparation method thereof |
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