CN105055801A - Composition for treating arrhythmia and making method - Google Patents
Composition for treating arrhythmia and making method Download PDFInfo
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Abstract
The invention discloses a composition for treating arrhythmia. The composition is made from, by weight, 10-16 parts of cortex cinnamomi, 7-13 parts of roots of common lantana, 9-14 parts of China roses, 6-12 parts of perny false fairybells rhizome, 8-13 parts of gordon euryale leaves, 7-12 parts of roots of indian strawberries, 9-13 parts of flowerbelge, 10-14 parts of spina date seeds, 8-15 parts of epiphyllum, 7-14 parts of common evolvulus herbs, 9-15 parts of polygala tenuifolia, 10-13 parts of phyllanthus virgatus, 7-11 parts of bauhinia championii, 9-12 parts of drumfishes and 8-14 parts of notopterygium roots. The composition is effective in treatment, remarkable in effect, safe, free of side effect, free of untoward effect, low in treatment cost, treating both symptoms and root causes and not prone to relapse.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the ARR compositions of a kind for the treatment of and method for making.
Background technology
Arrhythmia is because the exciting exception of sinuatrial node or excitement result from beyond sinuatrial node, exciting conduction slowly, retardance or through abnormal passage conduction, namely the origin of cardiomotility and (or) conductive impairment cause frequency and (or) the allorhythmia of heartbeat.Arrhythmia is one group of disease important in cardiovascular disease.Arrhythmia is found in various organic heart disease, wherein with coronary atherosclerotic heart disease (abbreviation coronary heart disease), cardiomyopathy, myocarditis and rheumatic heart disease (abbreviation rheumatic heart disease) are for common, especially when there is heart failure or acute myocardial infarction, occur in that arrhythmia in basic healthy person or autonomic nervous dysfunction patient is quite a few sees, other causes of disease still have electrolyte or endocrine disturbance, anesthesia, low temperature, thoracic cavity or operation on heart, drug effect and central nervous system disease etc., part etiology unknown.Clinical manifestation mainly contains following several: the performance of (1) coronary insufficiency.Various arrhythmia all can cause coronary artery blood flow to reduce, although various arrhythmia can cause coronary flow to reduce, but lessly cause myocardial ischemia, but, to the patient having coronary heart disease, various arrhythmia can be brought out or be increased the weight of myocardial ischemia, main manifestations is angina pectoris, breathes hard, peripheral vessels exhaustion, acute heart failure, acute myocardial infarction etc.(2) performance of cerebral arterial insufficiency.Different arrhythmia is also different on the impact of cerebral blood flow.The normal person of cerebrovascular, above-mentioned hemodynamic obstacle is unlikely causes serious consequence, if during cerebrovascular generation pathological changes, then be enough to cause cerebral blood supply insufficiency, it shows as dizziness, weak, blurred vision, temporary total blindness, the transient or permanent cerebral lesion performance such as aphasia, paralysis, tic, stupor even.(3) performance of renal artery blood supply insufficiency.After arrhythmia occurs, also there is different minimizings in renal blood flow, clinical manifestation has oliguria, albuminuria, azotemia etc.(4) performance of Mesenteric artery blood supply insufficiency.During tachy-arrhythmia, blood flow reduces, and Mesenteric artery spasm, can produce the clinical manifestation of gastrointestinal ischemia, and as abdominal distention, stomachache, diarrhoea, even occurs hemorrhage, ulcer or paralysis.(5) performance of cardiac insufficiency.Be mainly cough, dyspnea, asthenia, weak etc.
Treatment: (1) general treatment.Have at present and increase autorhythmia of cardiac by the Western medicine such as isoproterenol, atropine and (or) accelerate conduction, have by the treatment of the non-drug therapy such as cardiac pacemaker, electric defibrillation, radio-frequency (RF) ablation.In some cases, adopt oppression eyeball, massage carotid sinus, pinch nose forced expiration and the method such as to hold one's breath, also alleviate arrhythmia by reflex excitation vagus nerve.(2) conventional antiarrhythmic drug.The antiarrhythmic drug nearly more than 50 of existing clinical practice is planted, criteria for classification also ununified so far.Most scholars is agreed to divide following four classes to the different action principles of heart by antiarrhythmic drug according to medicine, and to instruct clinical rational drug use, wherein I class medicine is divided into again A, B, C tri-subclass.(1) I class and sodium channel blocade.1) I category-A, appropriate block sodium channels, what belong to this type of has the medicines such as quinidine.2) I category-B, slight block sodium channels, what belong to this type of has the medicines such as lignocaine.3) I C class, obvious block sodium channels, what belong to this type of has the medicines such as flecainide.(2) II classes are beta-adrenoceptor blocking drug, and because blocking beta receptor effectively, representative drugs is Propranolol.(3) III classes are the medicines selectively extending process of repolarization, and what belong to this type of has amiodarone.(4) IV class, i.e. calcium antagonistss.Their block calcium channel and suppress Ca
2+interior stream, representative medicine has verapamil.Long-term taking anti-arrhythmic all has side effect in various degree, serious caused ventricular arrhythmia or heart block and fatal.Therefore, strictly should grasp indication during clinical practice, note untoward reaction, to meet an urgent need at any time.
Application publication number CN102114231A(application number 201110073419.6) Chinese patent literature disclose one and treat ARR medicine, it is by Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Polygoni Ciliinerve, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Astragali Preparata, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Semen Ziziphi Spinosae, Semen Platycladi, Radix Curcumae, the Radix Aucklandiae, Pericarpium Citri Reticulatae Viride, Pericarpium Citri Reticulatae, Radix Polygalae, Caulis Perillae, Fructus Aurantii, Chinese medicine of licorice root is the medicament that crude drug obtains.Application publication number CN104758587A(application number 201510135638.0) Chinese patent literature disclose one and treat ARR Chinese medicine composition, its raw material of Chinese medicine and weight are: Radix Astragali 10-40 part, Bulbus Lilii 10-30 part, Poria 10-40 part, Os Draconis 5-20 part, Rhizoma Acori Graminei 5-20 part, Fructus Schisandrae Chinensis 5-20 part, Radix Ginseng 10-30 part, Radix Ophiopogonis 10-30 part, Pericarpium Citri Reticulatae 5-20 part, Flos Chrysanthemi 5-25 part, Dens Draconis 5-20 part, Radix Rehmanniae Preparata 5-25 part, Semen Persicae 10-30 part, Concha Margaritifera 5-20 part, Arillus Longan 5-25 part, Ramulus Cinnamomi 5-20 part, Radix Glycyrrhizae 5-15 part.Application publication number CN104208415A(application number 201410402573.7) Chinese patent literature disclose one and treat ARR Chinese medicine.The ARR Chinese medicine of this treatment, the raw material primarily of following parts by weight is made: Radix Codonopsis 2-5 part, Rhizoma Polygonati Odorati 2-6 part, Ganoderma 1-4 part, Herba pyrolae japonicae 1-5 part, Radix Astragali 2-5 part, Ramulus Cinnamomi 1-4 part, Radix Paeoniae Rubra 2-4 part, Rhizoma Acori Graminei 2-4 part, Herba Ephedrae 1-3 part, Rhizoma Chuanxiong 2-6 part, Radix Puerariae 1-3 part, Radix Glycyrrhizae 2-6 part, Pheretima 1-4 part, Fructus Arctii 2-5 part, Semen Platycladi 2-6 part, Radix Ophiopogonis 1-3 part, Rhizoma et radix valerianae 2.5-5 part, Fructus Schisandrae Chinensis 1-4 part, Caulis Spatholobi 1-4 part, Herba Eupatorii 1-4 part, Pericarpium Arecae 2-4 part, Caulis Perillae Frutescentis 1-2 part, Concha Tridacna squamosa 1-3 part, Rhodobryum roseum Limpr. 2-5 part.
Current, ARR treatment is mainly based on medicine, and nearly all anti-arrhythmic, suppress the self-disciplining conductivity of heart and the contractile function of heart all to some extent, also nearly all anti-arrhythmic has arrhythogenic untoward reaction.As I class anti-arrhythmic determined curative effect, it is also very outstanding that it causes new ARR untoward reaction; Though beta-blockers can reduce mortality rate, bradyarrhythmia can be caused; Amiodarone effect is comprehensive, but there is the outer internal organs untoward reaction of the serious heart, limits its prolonged application.Non-drug therapy such as the research of the item such as automatic defibrillator, operation on heart technology in radio-frequency (RF) ablation, artificial cardiac pacemaker, embedded type body is advanced by leaps and bounds, but because of its technical sophistication costly, limit the popularization and application of this type of technology to a certain extent.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide the ARR compositions of a kind for the treatment of and method for making.Determined curative effect of the present invention, Be very effective, safety, has no side effect, and can not produce untoward reaction, medical expense is lower, and treating both the principal and secondary aspects of a disease not easily recurs.
Technical scheme of the present invention is:
The ARR compositions of a kind for the treatment of, takes off the primary raw material medicine stating weight proportion and is prepared from: Cortex Cinnamomi 10-16, Radix Lantanae Camaraev 7-13, Flos Rosae Chinensis 9-14, Rhizoma disporopsis pernyi 6-12, Folium Euryales 8-13, Radix duchesneae indicae 7-12, Coagulum Opuntiae sucus 9-13, Semen Ziziphi Spinosae 10-14, Flos Epiphylli Oxypetali 8-15, Herba Evolvuli Alsinoides 7-14, Radix Polygalae 9-15, Phyllanthus simplex Retz． 10-13, Caulis Bauhihiae Championii 7-11, Carnis Pseudosciaenae 9-12, Rhizoma Et Radix Notopterygii 8-14.
The ARR compositions of a kind for the treatment of, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Cortex Cinnamomi 12-15, Radix Lantanae Camaraev 9-11, Flos Rosae Chinensis 10-12, Rhizoma disporopsis pernyi 8-11, Folium Euryales 9-12, Radix duchesneae indicae 9-11, Coagulum Opuntiae sucus 10-12, Semen Ziziphi Spinosae 11-13, Flos Epiphylli Oxypetali 10-14, Herba Evolvuli Alsinoides 9-12, Radix Polygalae 11-13, Phyllanthus simplex Retz． 11-12, Caulis Bauhihiae Championii 8-10, Carnis Pseudosciaenae 10-11, Rhizoma Et Radix Notopterygii 9-12.
The ARR compositions of a kind for the treatment of, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Cortex Cinnamomi 13, Radix Lantanae Camaraev 10, Flos Rosae Chinensis 11, Rhizoma disporopsis pernyi 9, Folium Euryales 10, Radix duchesneae indicae 10, Coagulum Opuntiae sucus 11, Semen Ziziphi Spinosae 12, Flos Epiphylli Oxypetali 13, Herba Evolvuli Alsinoides 11, Radix Polygalae 12, Phyllanthus simplex Retz． 11.5, Caulis Bauhihiae Championii 9, Carnis Pseudosciaenae 10.5, Rhizoma Et Radix Notopterygii 10.
Present invention also offers the preparation method ARR for aforementioned treatment compositions being made pharmaceutically acceptable powder, pill, capsule and granule.
The preparation method of described powder is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 170 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 170 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 170 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with 4g often bag subpackage, sterile packaged, to obtain final product.
The preparation method of described pill is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 140 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with water pill, make the pill that particle diameter is 2mm, dry, to obtain final product.
The preparation method of described capsule is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 140 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, load in Capsules, medicated powder 0.25g is housed in every capsules, obtains final product.
The preparation method of described granule is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the clear paste that relative density is 1.28;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the clear paste that relative density is 1.28;
(5) step (1), step (2), step (3) and step (4) gained are mixed, stir, add soluble starch, the weight of soluble starch is step (1), the weight of the preferred soluble starch of 1/12-1/8(of step (2), step (3) and step (4) gained gained gross weight is 1/10 of step (1), step (2), step (3) and step (4) gained gross weight), make granule, drying, to obtain final product.
The ARR compositions scientific formula for the treatment of provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, determined curative effect, Be very effective;
2, safety, has no side effect, and can not produce untoward reaction;
3, medical expense is lower, easy to patients;
4, treating both the principal and secondary aspects of a disease, not easily recurs;
5, there is effect of warming the meridian and promoting blood circulation, clearing away heat-fire, tranquilizing by nourishing the heart, benefiting QI for activating blood circulation, yin nourishing arresting sweating, finally reach and control
More ARR object.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the ARR compositions of a kind for the treatment of, the primary raw material medicine getting following weight parts is prepared from (every part is 720g): Cortex Cinnamomi 10 parts, Radix Lantanae Camaraev 7 parts, Flos Rosae Chinensis 9 parts, Rhizoma disporopsis pernyi 6 parts, Folium Euryales 8 parts, Radix duchesneae indicae 7 parts, Coagulum Opuntiae sucus 9 parts, Semen Ziziphi Spinosae 10 parts, Flos Epiphylli Oxypetali 8 parts, 7 parts, Herba Evolvuli Alsinoides, Radix Polygalae 9 parts, Phyllanthus simplex Retz． 10 parts, Caulis Bauhihiae Championii 7 parts, Carnis Pseudosciaenae 9 parts, Rhizoma Et Radix Notopterygii 8 parts.
The preparation method of the ARR compositions powder of above-mentioned treatment is:
(1) get Cortex Cinnamomi, pulverize, cross 30 mesh sieves, add the ethanol of 8.5 times amount, the volume fraction of ethanol is 55%, continuous circumfluence extraction 8 hours, and filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 170 mesh sieves are crossed, drying 6 hours at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30 minutes, takes out, dries, be ground into fine powder, crosses 170 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water of 11 taste crude drug gross weight 6 times amount, decoct 30 minutes, leaching medicinal liquid, add the water of 11 taste crude drug gross weight 3.5 times amount in medicinal residues again, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 170 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with 4g often bag subpackage, sterile packaged, to obtain final product.
The instructions of taking that gained of the present invention cures ARR compositions powder is: oral, one day twice, and each 4g, boiled water is taken after mixing it with water.
embodiment 2the ARR compositions of a kind for the treatment of, the primary raw material medicine getting following weight parts is prepared from (every part is 720g): Cortex Cinnamomi 16 parts, Radix Lantanae Camaraev 13 parts, Flos Rosae Chinensis 14 parts, Rhizoma disporopsis pernyi 12 parts, Folium Euryales 13 parts, Radix duchesneae indicae 12 parts, Coagulum Opuntiae sucus 13 parts, Semen Ziziphi Spinosae 14 parts, Flos Epiphylli Oxypetali 15 parts, 14 parts, Herba Evolvuli Alsinoides, Radix Polygalae 15 parts, Phyllanthus simplex Retz． 13 parts, Caulis Bauhihiae Championii 11 parts, Carnis Pseudosciaenae 12 parts, Rhizoma Et Radix Notopterygii 14 parts.
The preparation method of the ARR compositions pill of above-mentioned treatment is:
(1) get Cortex Cinnamomi, pulverize, cross 30 mesh sieves, add the ethanol of 10 times amount, the volume fraction of ethanol is 65%, continuous circumfluence extraction 8 hours, and filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, drying 8 hours at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 36 minutes, takes out, dries, be ground into fine powder, crosses 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water of 11 taste crude drug gross weight 6.5 times amount, decoct 30 minutes, leaching medicinal liquid, add the water of 11 taste crude drug gross weight 4.6 times amount in medicinal residues again, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 140 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with water pill, make the pill that particle diameter is 2mm, dry, to obtain final product.
model case one:king XX, female, 42 years old.Main suit: more than nervous half a year.Before half a year, having palpitation appears in patient, automatically alleviates, recurrent exerbation after continuing half an hour.Once Chinese and western medicine Drug therapy was taken, without taking a turn for the better.Then I treats at institute.Patient's palpitation and uneasiness, in the heart dysphoria with smothery sensation, dry pharynx, oliguria with yellow urine, red tongue, yellow and thin fur, thready and rapid pulse.Electrocardioscopy: sinus rhythm, accidental ventricular premature contraction.Be diagnosed as arrhythmia.Take the present embodiment gained and cure ARR compositions pill, one day twice, each 4 balls, warm water takes.Take 1 week, symptom is clearly better.Take two weeks, all diseases are eliminated, and Electrocardioscopy is normal.Follow up a case by regular visits to and do not recur.
embodiment 3the ARR compositions of a kind for the treatment of, the primary raw material medicine getting following weight parts is prepared from (every part is 720g): Cortex Cinnamomi 12 parts, Radix Lantanae Camaraev 9 parts, Flos Rosae Chinensis 10 parts, Rhizoma disporopsis pernyi 8 parts, Folium Euryales 9 parts, Radix duchesneae indicae 9 parts, Coagulum Opuntiae sucus 10 parts, Semen Ziziphi Spinosae 11 parts, Flos Epiphylli Oxypetali 10 parts, 9 parts, Herba Evolvuli Alsinoides, Radix Polygalae 11 parts, Phyllanthus simplex Retz． 11 parts, Caulis Bauhihiae Championii 8 parts, Carnis Pseudosciaenae 10 parts, Rhizoma Et Radix Notopterygii 9 parts.
The preparation method of the ARR composition capsule of above-mentioned treatment is:
(1) get Cortex Cinnamomi, pulverize, cross 30 mesh sieves, add the ethanol of 10 times amount, the volume fraction of ethanol is 65%, continuous circumfluence extraction 8 hours, and filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, drying 8 hours at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 36 minutes, takes out, dries, be ground into fine powder, crosses 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water of 11 taste crude drug gross weight 6.5 times amount, decoct 30 minutes, leaching medicinal liquid, add the water of 11 taste crude drug gross weight 4.6 times amount in medicinal residues again, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 140 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, load in Capsules, medicated powder 0.25g is housed in every capsules, obtains final product.
model case two:old XX, man, 56 years old.Main suit: arrhythmia more than 1 year.Before 1 year, there is the symptom such as cardiopalmus, feeling of oppression and pain in the chest in patient.To local hospital inspection, be diagnosed as arrhythmia.Take multiple Chinese and western medical thing, but be easy to recurrence.Then medical.Patient's palpitation and restlessness, shortness of breath and fatigue, dynamic then aggravate, suffocating pain over the chest, with dizziness.Electrocardioscopy is pointed out: sinus rhythm, heart rate 92 times/min.Be diagnosed as arrhythmia.Take the present embodiment gained and cure ARR composition capsule, one day twice, each 2, warm water takes.Take 7 days, cardiopalmus, feeling of oppression and pain in the chest obviously improve.Take two weeks, above-mentioned symptom disappears, and Electrocardioscopy is without exception.Follow up a case by regular visits to and do not recur.
embodiment 4the ARR compositions of a kind for the treatment of, the primary raw material medicine getting following weight parts is prepared from (every part is 720g): Cortex Cinnamomi 15 parts, Radix Lantanae Camaraev 11 parts, Flos Rosae Chinensis 12 parts, Rhizoma disporopsis pernyi 11 parts, Folium Euryales 12 parts, Radix duchesneae indicae 11 parts, Coagulum Opuntiae sucus 12 parts, Semen Ziziphi Spinosae 13 parts, Flos Epiphylli Oxypetali 14 parts, 12 parts, Herba Evolvuli Alsinoides, Radix Polygalae 13 parts, Phyllanthus simplex Retz． 12 parts, Caulis Bauhihiae Championii 10 parts, Carnis Pseudosciaenae 11 parts, Rhizoma Et Radix Notopterygii 12 parts.
The preparation method of the ARR composition granule of above-mentioned treatment is:
(1) get Cortex Cinnamomi, pulverize, cross 30 mesh sieves, add the ethanol of 10 times amount, the volume fraction of ethanol is 65%, continuous circumfluence extraction 8 hours, and filter, filtrate recycling ethanol is also condensed into the clear paste that relative density is 1.28;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, drying 8 hours at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 36 minutes, takes out, dries, be ground into fine powder, crosses 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water of 11 taste crude drug gross weight 6.5 times amount, decoct 30 minutes, leaching medicinal liquid, add the water of 11 taste crude drug gross weight 4.6 times amount in medicinal residues again, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the clear paste that relative density is 1.28;
(5) step (1), step (2), step (3) and step (4) gained are mixed, stir, add soluble starch, the weight of soluble starch is 1/10 of step (1), step (2), step (3) and step (4) gained gained gross weight, make granule, drying, to obtain final product.
model case three: Wu XX, female, 47 years old.Main suit: uncomfortable in chest, more than shortness of breath and palpitation JIUYUE.Before nine months, patient occurs uncomfortable in chest, symptom of breathing hard.After taking Western medicine, symptom is alleviated to some extent, but the state of an illness is instead sent out repeatedly.Then to our hospital.Patient's shortness of breath and palpitation, weak breath is unable, palpitation with a distress feeling, and painful abdominal mass is vexed in the heart, is very at nightfall, and fear of cold happiness temperature, clear urine in large amounts, pale tongue tongue is white, deep-slow pulse.Heart rate 53 times/min, hear sounds is weak, without noise, respiratory frequency 26 times/min.Be diagnosed as arrhythmia.Take the present embodiment gained and cure ARR composition granule, one day twice, each 8g, boiled water is taken after mixing it with water.Medication is after 1 week, and symptom is obviously improved.After two weeks, all transference cures, Electrocardioscopy is without exception.Follow up a case by regular visits to and do not recur.
embodiment 5the ARR compositions of a kind for the treatment of, the primary raw material medicine getting following weight parts is prepared from (every part is 720g): Cortex Cinnamomi 13 parts, Radix Lantanae Camaraev 10 parts, Flos Rosae Chinensis 11 parts, Rhizoma disporopsis pernyi 9 parts, Folium Euryales 10 parts, Radix duchesneae indicae 10 parts, Coagulum Opuntiae sucus 11 parts, Semen Ziziphi Spinosae 12 parts, Flos Epiphylli Oxypetali 13 parts, 11 parts, Herba Evolvuli Alsinoides, Radix Polygalae 12 parts, Phyllanthus simplex Retz． 11.5 parts, Caulis Bauhihiae Championii 9 parts, Carnis Pseudosciaenae 10.5 parts, Rhizoma Et Radix Notopterygii 10 parts.
The preparation method of the ARR compositions powder of above-mentioned treatment is:
(1) get Cortex Cinnamomi, pulverize, cross 30 mesh sieves, add the ethanol of 10 times amount, the volume fraction of ethanol is 65%, continuous circumfluence extraction 8 hours, and filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 170 mesh sieves are crossed, drying 8 hours at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 36 minutes, takes out, dries, be ground into fine powder, crosses 170 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water of 11 taste crude drug gross weight 6.5 times amount, decoct 30 minutes, leaching medicinal liquid, add the water of 11 taste crude drug gross weight 4.6 times amount in medicinal residues again, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 170 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with 4g often bag subpackage, sterile packaged, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Cortex Cinnamomi: base is former: be dried bark, the branch skin of Lauraceae cinnamon Cortex Cinnamomi.Composition: Cortex cinnamomi japonici (Ramulus Cinnamomi) is containing volatile oil 1.89%-2.06%, and its main component is cinnamic aldehyde, accounts for 52.92%-61.20%, also has acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, ethyl cinnamate, benzaldehyde benzyl ester, benzaldehyde, coumarin etc.The property of medicine: pungent, sweet, heat.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG, the aversion to cold and cold limbs of decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission; dysuria or frequency, dyspnea with rapid and short breath of losing heart, all diseases of edema oliguria, decline of the fire from the gate of life, fire is Gui Yuan not; floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot; dizziness and tinnitus, and dispute gruel is broken, spleen-kidney vacuity cold, coldness and pain in the epigastrium; decreased food intake loose stool, lumbago due to renal deficiency, arthralgia due to cold-dampnes, colic of cold type pain, and cold womb is infertile, dysmenorrhea amenorrhea; be retarded by silt puerperal stomachache, carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.
Radix Lantanae Camaraev: base is former: be the root of Verbenaceae lantana.The property of medicine: bitter in the mouth; Cold in nature.Return bladder, liver, kidney channel.Function cures mainly: clearing away heat-fire; Detoxicating and resolving stagnation of pathogens.Main cold, fever, summer-heat headache; Toothache due to stomach-fire; Pharyngolaryngitis; Mumps; Rheumatic arthralgia; Scrofula sucutaneous nodule.
Flos Rosae Chinensis: base is former: be the flower of rosaceous plant Flos Rosae Chinensis.The property of medicine: sweet; Temperature; Nontoxic.Return liver, kidney channel.Function cures mainly: promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Main menoxenia, dysmenorrhea, amenorrhea, traumatic injury, swelling and pain due to blood stasis, scrofula, carbuncle, scalds.
Rhizoma disporopsis pernyi: base is former: be the rhizome of liliaceous plant D. pernyi.The property of medicine: sweet in the mouth; Property is put down.Function cures mainly: replenishing QI to invigorate the spleen; Nourishing YIN and moistening the lung; Relaxing muscles and tendons to promote blood circulation.Main puerperal asthenia; Infantile malnutrition; Cough due to yin deficiency; Hyperhidrosis; Xerostomia; Treating swelling and pain by traumatic injury; Rheumatalgia; Lumbago.
Folium Euryales: base is former: be the leaf of nymphaeaceae plant Gorgon euryale.The property of medicine: bitter; Pungent; Flat.Return liver, kidney channel.Function cures mainly: promoting flow of QI and blood; Hemostasis by removing blood stasis.Main haematemesis; Have blood in stool; Women's retention of placenta in puerperal.
Radix duchesneae indicae: base is former: be the root of rosaceous plant Herba Duchesneae Indicae.The property of medicine: bitter, sweet; Cold.Return lung, liver, stomach warp.Function cures mainly: clearing away heat-fire; Removing toxic substances and promoting subsidence of swelling.Main calentura, water infantile convulsion, conjunctival congestion is red and swollen, mumps, gingival swelling and pain, laryngopharynx swelling and pain, pathopyretic ulcer.
Coagulum Opuntiae sucus: base is former: be the juice concretion flowed out in the fleshy stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.The property of medicine: sweet; Cold in nature.Function cures mainly: clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Main hemorrhoidal bleeding; Have blood in stool; Furuncle swells; Scald; Palpitation with a distress feeling; Acute infantile convulsion wind.
Semen Ziziphi Spinosae: base is former: the seed of Rhamnaceae plant Ziziphi Spinosae.The property of medicine: sweet; Flat.GUIXIN, spleen, liver, gallbladder meridian.Function cures mainly: mind tranquilizing and the heart calming; Nourishing the liver; Arresting sweating.Main restlessness of asrhenia type and insomnia; Palpitation with fear palpitation with a distress feeling; Body empty spontaneous perspiration, night sweat.
Flos Epiphylli Oxypetali: base is former: be the flower of Cactaeous plants Flos Epiphylli Oxypetali.The property of medicine: sweet; Property is put down.Return lung, heart channel.Function cures mainly: clearing away lung-heat to relieve cough; Cooling blood for hemostasis; Tranquilizing by nourishing the heart.Main cough due to lung-heat; Pulmonary tuberculosis; Spitting of blood; Metrorrhagia; Cardiopalmus; Insomnia.
Herba Evolvuli Alsinoides: base is former: be the herb of dicotyledon scammonia section plant Herba Evolvuli Alsinoides.The property of medicine: sweet, bitter; Cool.Return liver,spleen,kidney warp.Function cures mainly: heat clearing away; Dampness removing; Removing toxic substances.Main jaundice; Dysentery; Stranguria with turbid discharge; Leukorrhagia; Treat swollen; Scabies.
Radix Polygalae: base is former: be the dry root of milk wort Radix Polygalae or ovum leaf Radix Polygalae.The property of medicine: bitter, pungent, temperature.GUIXIN, kidney, lung meridian.Function cures mainly: Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Phyllanthus simplex Retz．: base is former: be the herb of euphorbia plant Phyllanthus simplex Retz．.The property of medicine: sweet, bitter, flat.Return spleen channel.Function cures mainly: spleen invigorating removing food stagnancy, inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing.Main infantile malnutrition, dysentery, gonorrhea, acute mastitis, ulcerative gingivitis, venom.
Caulis Bauhihiae Championii: base is former: be root or the stem of leguminous plant Caulis Bauhiniae Championii.The property of medicine: bitter; Flat; Nontoxic.Return liver, kidney channel.Function cures mainly: expelling wind and removing dampness, promoting flow of QI and blood.Main air pain of dampness syndrome, traumatic injury, hemiplegia, gastric abscess, infantile malnutrition, dysentery.
Carnis Pseudosciaenae: base is former: for Sciaenidae Channa argus belongs to the meat of animal Carnis Pseudosciaenae and Carnis Pseudosciaenae.Composition: use part containing protein, fat, moisture, calcium, phosphorus, ferrum, sulphuric acid element, riboflavin, nicotinic acid, iodine etc.The property of medicine: sweet, salty, flat.Return stomach, liver, kidney channel.Function cures mainly: QI invigorating nourishing the stomach, the kidney invigorating, improving eyesight.Cure mainly after being ill, puerperal asthenia, hypogalactia, lumbago due to renal deficiency, edema, blurring of vision.
Rhizoma Et Radix Notopterygii: base is former: be dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.The property of medicine: pungent, bitter, temperature.Return bladder, kidney channel.Function cures mainly: cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
test example 1gained of the present invention cures the clinical practice of ARR compositions (embodiment 5): in October ,-2012 in April, 2011, screen 320 routine patients with arrhythmia in 4 hospitals, wherein male 146 example; women 174 example; oldest 70 years old, minimum 35 years old of age, 52 years old mean age.Be divided into two groups at random, experimental group and matched group (often organizing 160 people).Two groups of patients no difference of science of statistics (P > 0.05) in sex, age, physical data etc., has good comparability.Experimental group takes products obtained therefrom of the present invention, instructions of taking: oral, one day twice, each 4g, and boiled water is taken after mixing it with water, and within seven days, is a course for the treatment of.Matched group uses the Drug therapys such as Amiodarone hydrochloride injection, Propranolol, Propafenone, within seven days, is a course for the treatment of.Therapeutic evaluation is carried out after two groups of patients all treat two courses for the treatment of.
Curative effect situation criterion: cure: clinical symptoms all disappears, lab testing is normal, and electrocardiogram recovers normal; Effective: clinical symptoms obviously alleviates, lab testing obviously improves, and electrocardiogram takes a turn for the better; Take a turn for the better: clinical symptoms alleviates to some extent, and lab testing makes moderate progress, electrocardiogram takes a turn for the better; Invalid: symptom is without improvement or increase the weight of.Result is as shown in table 1.Always effectively comprise recovery from illness, effective and improvement.
Table 1: the present invention cures the checking of ARR composition effect
efficacy analysis:as can be seen from Table 1, after two groups of cases treat two courses for the treatment of, experimental group cures 104 examples, effective 38 examples, and take a turn for the better 14 examples, invalid 4 examples, total effective rate 97.5%; Matched group cures 45 examples, effective 43 examples, and take a turn for the better 28 examples, invalid 44 examples, total effective rate 72.5%.The cure rate of experimental group and total effective rate are apparently higher than matched group.
The present invention is primary raw material medicine with Cortex Cinnamomi, Radix Lantanae Camaraev, Flos Rosae Chinensis and Rhizoma disporopsis pernyi etc., makes and cures ARR compositions.In side, Cortex Cinnamomi is mended fiery supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Radix Lantanae Camaraev clearing away heat-fire; Detoxicating and resolving stagnation of pathogens.Flos Rosae Chinensis promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Rhizoma disporopsis pernyi replenishing QI to invigorate the spleen; Nourishing YIN and moistening the lung; Relaxing muscles and tendons to promote blood circulation.Folium Euryales promoting flow of QI and blood; Hemostasis by removing blood stasis.Radix duchesneae indicae clearing away heat-fire; Removing toxic substances and promoting subsidence of swelling.Coagulum Opuntiae sucus clearing away heat and cooling blood; Tranquilizing by nourishing the heart.Semen Ziziphi Spinosae mind tranquilizing and the heart calming; Nourishing the liver; Arresting sweating.Flos Epiphylli Oxypetali clearing away lung-heat to relieve cough; Cooling blood for hemostasis; Tranquilizing by nourishing the heart.Herba Evolvuli Alsinoides heat clearing away; Dampness removing; Removing toxic substances.Radix Polygalae is calmed the nerves Fructus Alpiniae Oxyphyllae, eliminates the phlegm, detumescence.Phyllanthus simplex Retz． spleen invigorating removing food stagnancy, inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing.Caulis Bauhihiae Championii expelling wind and removing dampness, promoting flow of QI and blood.The nourishing the stomach of Carnis Pseudosciaenae QI invigorating, the kidney invigorating, improving eyesight.Rhizoma Et Radix Notopterygii cold expelling, dispels the wind, dehumidifying, pain relieving.Many medicines share, and mutually coordinate, play effect of warming the meridian and promoting blood circulation, clearing away heat-fire, tranquilizing by nourishing the heart, benefiting QI for activating blood circulation, yin nourishing arresting sweating altogether, finally reach and cure ARR object.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. cure an ARR compositions, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 10-16, Radix Lantanae Camaraev 7-13, Flos Rosae Chinensis 9-14, Rhizoma disporopsis pernyi 6-12, Folium Euryales 8-13, Radix duchesneae indicae 7-12, Coagulum Opuntiae sucus 9-13, Semen Ziziphi Spinosae 10-14, Flos Epiphylli Oxypetali 8-15, Herba Evolvuli Alsinoides 7-14, Radix Polygalae 9-15, Phyllanthus simplex Retz． 10-13, Caulis Bauhihiae Championii 7-11, Carnis Pseudosciaenae 9-12, Rhizoma Et Radix Notopterygii 8-14.
2. the ARR compositions for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 12-15, Radix Lantanae Camaraev 9-11, Flos Rosae Chinensis 10-12, Rhizoma disporopsis pernyi 8-11, Folium Euryales 9-12, Radix duchesneae indicae 9-11, Coagulum Opuntiae sucus 10-12, Semen Ziziphi Spinosae 11-13, Flos Epiphylli Oxypetali 10-14, Herba Evolvuli Alsinoides 9-12, Radix Polygalae 11-13, Phyllanthus simplex Retz． 11-12, Caulis Bauhihiae Championii 8-10, Carnis Pseudosciaenae 10-11, Rhizoma Et Radix Notopterygii 9-12.
3. the ARR compositions for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 13, Radix Lantanae Camaraev 10, Flos Rosae Chinensis 11, Rhizoma disporopsis pernyi 9, Folium Euryales 10, Radix duchesneae indicae 10, Coagulum Opuntiae sucus 11, Semen Ziziphi Spinosae 12, Flos Epiphylli Oxypetali 13, Herba Evolvuli Alsinoides 11, Radix Polygalae 12, Phyllanthus simplex Retz． 11.5, Caulis Bauhihiae Championii 9, Carnis Pseudosciaenae 10.5, Rhizoma Et Radix Notopterygii 10.
4. the ARR compositions for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, ARR for this treatment compositions is made pharmaceutically acceptable powder, and the preparation method of described powder is:
(1) get Cortex Cinnamomi, pulverize, cross 30 mesh sieves, add the ethanol of 8.5-10.5 times amount, the volume fraction of ethanol is 55%-75%, continuous circumfluence extraction 8 hours, and filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 170 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute, takes out, dries, be ground into fine powder, crosses 170 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 170 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with 4g often bag subpackage, sterile packaged, to obtain final product.
5. the ARR compositions for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, ARR for this treatment compositions is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 140 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, with water pill, make the pill that particle diameter is 2mm, dry, to obtain final product.
6. the ARR compositions for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, ARR for this treatment compositions is made pharmaceutically acceptable capsule, and the preparation method of described capsule is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.36;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the thick paste that relative density is 1.36;
(5) by step (1) and the mixing of step (4) gained, 50 DEG C of dryings 9 hours, altogether porphyrize powder, cross 140 mesh sieves;
(6) step (2), step (3) and step (5) gained are mixed, stir, load in Capsules, medicated powder 0.25g is housed in every capsules, obtains final product.
7. the ARR compositions for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, ARR for this treatment compositions is made pharmaceutically acceptable granule, and the preparation method of described granule is:
(1) Cortex Cinnamomi is got, pulverize, cross 30 mesh sieves, add the ethanol (preferably adding the ethanol of 10 times amount) of 8.5-10.5 times amount, the volume fraction of ethanol is the volume fraction of 55%-75%(preferred alcohol is 65%), continuous circumfluence extraction 8 hours, filter, filtrate recycling ethanol is also condensed into the clear paste that relative density is 1.28;
(2) by Flos Rosae Chinensis and Flos Epiphylli Oxypetali porphyrize powder altogether, 140 mesh sieves are crossed, dry 6-9 hour (preferably 60 DEG C at dry 8 hours) at 60 DEG C;
(3) by Carnis Pseudosciaenae belly breaking, clean, upper pot steams 30-40 minute (preferably upper pot steams 36 minutes), takes out, dries, be ground into fine powder, cross 140 mesh sieves;
(4) all the other the 11 taste crude drug except Cortex Cinnamomi, Flos Rosae Chinensis, Flos Epiphylli Oxypetali and Carnis Pseudosciaenae are put in pot, add the water (preferably adding the water of 11 taste crude drug gross weight 6.5 times amount) of 11 taste crude drug gross weight 6-7 times amount, decoct 30 minutes, leaching medicinal liquid, the water (adding the water of 11 taste crude drug gross weight 4.6 times amount in preferred medicinal residues again) of 11 taste crude drug gross weight 3.5-5 times amount is added again in medicinal residues, decoct 25 minutes, leaching medicinal liquid, merge twice medicinal liquid, be condensed into the clear paste that relative density is 1.28;
(5) step (1), step (2), step (3) and step (4) gained are mixed, stir, add soluble starch, the weight of soluble starch is step (1), the weight of the preferred soluble starch of 1/12-1/8(of step (2), step (3) and step (4) gained gained gross weight is 1/10 of step (1), step (2), step (3) and step (4) gained gross weight), make granule, drying, to obtain final product.
8. the preparation method curing ARR compositions powder as claimed in claim 4, is characterized in that, add the ethanol of 10 times amount in step (1).
9. the preparation method curing ARR compositions powder as claimed in claim 4, is characterized in that, in step (1), the volume fraction of ethanol is 65%.
10. the preparation method curing ARR compositions powder as claimed in claim 4, is characterized in that, in step (3), upper pot steams 36 minutes.
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| KR20080034154A (en) * | 2005-07-14 | 2008-04-18 | 내셔널 인스티튜트 오브 파마슈티컬 알앤디 컴퍼니 리미티드 | Medicinal composition containing ginseng secondary glycosides, its preparation method and application |
| CN103385995A (en) * | 2013-07-18 | 2013-11-13 | 北京中医药大学东方医院 | Traditional Chinese medicine compound for treating arrhythmia and preparation method thereof |
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| KR20080034154A (en) * | 2005-07-14 | 2008-04-18 | 내셔널 인스티튜트 오브 파마슈티컬 알앤디 컴퍼니 리미티드 | Medicinal composition containing ginseng secondary glycosides, its preparation method and application |
| CN103385995A (en) * | 2013-07-18 | 2013-11-13 | 北京中医药大学东方医院 | Traditional Chinese medicine compound for treating arrhythmia and preparation method thereof |
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Address after: 810000 Qinghai Province, Eastern District of Xining City Garden No. 21 North Street, building 3, Oriental Pearl 2-501 Applicant after: Huo Tongyan Address before: 250000 Shandong, Ji'nan, East Industrial and Commercial Road Flyover District No. 13 Applicant before: Huo Tongyan |
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Application publication date: 20151118 |