CN105288375A - Foot bath liquid for treating callosity and preparation method thereof - Google Patents
Foot bath liquid for treating callosity and preparation method thereof Download PDFInfo
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- CN105288375A CN105288375A CN201510767600.5A CN201510767600A CN105288375A CN 105288375 A CN105288375 A CN 105288375A CN 201510767600 A CN201510767600 A CN 201510767600A CN 105288375 A CN105288375 A CN 105288375A
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Abstract
The invention discloses a foot bath liquid for treating callosity. The foot bath liquid comprises the following raw material in parts by weight: 15-45 parts of prunella vulgaris, 13-34 parts of sweet osmanthus, 13-34 parts of Sparganium stoloniferum, 13-34 parts of fiveleaf akebia fruit, 13-34 parts of rhizoma nardostachyos, 10-28 parts of propolis and 8-22 parts of Chinese gall. The invention also discloses a preparation method of the foot bath liquid. The foot bath liquid has the obvious efficacy for treating callosity, improving ulcer, and reducing blood pressure and blood glucose, and can mitigate pain caused by foot ulcer of diabetes patients due to callosity.
Description
Technical field
The present invention relates to article of everyday use technical field, more specifically relate to a kind of foot-soaking liquid for the treatment of callus and preparation method thereof.
Background technology
Callus is because excessive mechanical pressure makes Keratinocytic activity increase, and forms blocked up horny layer, is partially formed callus.Callus increases pressure load again, and the foot tissue below callus, owing to bearing larger pressure, hemorrhage, liquefaction and necrosis very easily occurs and forms ulcer.Callus principal pathogenetic crowd has middle-aged and elderly people, modern young spark women, and in addition, in Bing Fa colony, diabetes Genus Homo is wherein a kind of.
Show according to about the investigation of callus on plantar pressure and ulcer impact, corpus callosum can make local pressure increase by more than 29%, and the danger that ulcer is occurred increases by 11 times.Have research display, China's diabetics number is up to 1.14 hundred million, and wherein the diabetics of 12% ~ 25% at least a foot ulcers occurs in life, and diabetic foot ulcer becomes a huge health problem.Because diabetic neuropathy's change causes insensitive, callus covers skin surface in addition, not easily finds the ulcer of deep layer, and the ulcer causing callus to cause is difficult to be found in early days.The high risk factor that callus occurs as ulcer of foot, should cause the attention of medical personnel.But domestic at present also do not have special podiatrist, a lot of patient selects oneself process callus or the pedicure work of seeking help from society, and often can cause infecting because deal with improperly, severe patient even can cause amputation.Because diabetics vola skin is easy to breakage, its foot neuropathy induced pain sense decline in addition, immunity of organisms difference and easily infected, medicine and the aid of many treatment calluss have injury in various degree to diabetics.For this reason, be in fact necessary to provide a kind of safe and effective approach for prevention and therapy callus, alleviate diabetics because of callus and cause the misery of foot ulcers, simultaneously for diabetics provides more more options approach.
Summary of the invention
Based on this, first object of the present invention is to provide a kind of foot-soaking liquid for the treatment of callus.
The concrete technical scheme solved the problems of the technologies described above is as follows:
Treat a foot-soaking liquid for callus, the active component of described foot-soaking liquid comprises the raw material of following weight parts: Spica Prunellae 15 ~ 45 parts, Flos Osmanthi Fragrantis 13 ~ 34 parts, Rhizoma Sparganii 13 ~ 34 parts, Fructus Akebiae 13 ~ 34 parts, Radix Et Rhizoma Nardostachyos 13 ~ 34 parts, propolis 10 ~ 28 parts, Galla Chinensis 8 ~ 22 parts.
Wherein in some embodiments, the active component of described foot-soaking liquid comprises the raw material of following weight parts: Spica Prunellae 25 ~ 35 parts, Flos Osmanthi Fragrantis 17 ~ 24 parts, Rhizoma Sparganii 17 ~ 24 parts, Fructus Akebiae 17 ~ 24 parts, Radix Et Rhizoma Nardostachyos 17 ~ 24 parts, propolis 12 ~ 19 parts, Galla Chinensis 8 ~ 15 parts.
Wherein in some embodiments, the active component of described foot-soaking liquid comprises the raw material of following weight parts: Spica Prunellae 30 parts, Flos Osmanthi Fragrantis 20 parts, Rhizoma Sparganii 20 parts, Fructus Akebiae 20 parts, Radix Et Rhizoma Nardostachyos 20 parts, propolis 15 parts, Galla Chinensis 10 parts.
Wherein in some embodiments, above-mentioned Spica Prunellae is preferably with the herb of mature fruit cluster.
Wherein in some embodiments, the preferred silver-colored osmanthus of above-mentioned Flos Osmanthi Fragrantis.
Another object of the present invention is to the preparation method providing a kind of above-mentioned foot-soaking liquid, it comprises the following steps:
(1) first Galla Chinensis is cleaned, remove impurity, fry 15 ~ 25 minutes at 135 DEG C ~ 155 DEG C;
(2) Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, removing impurity is placed in saucepan, add the water boil of Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos three gross weight 10 ~ 12 times amount, decoction 25 ~ 35 minutes are continued after water boils, add again Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos three gross weight 4 ~ 7 times amount vinegar decoct 15 ~ 20 minutes, stop heating, to stay in pot vexed 6 ~ 8 hours, dry;
(3) by cleaning, dry Spica Prunellae, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 70% ~ 85%, 60 DEG C ~ 70 DEG C ultrasonic extraction 30 ~ 40 minutes, sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:8 ~ 12;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, ultrasonic extraction 20 ~ 30 minutes at 60 DEG C ~ 70 DEG C, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, namely concentrate drying to 3/10 ~ 1/2 times of original volume obtains described foot-soaking liquid.
Wherein in some embodiments, described in above-mentioned foot-soaking liquid preparation process, hyperacoustic power is 150 ~ 200W.
Vinegar described in the preparation method of above foot-soaking liquid is commercially available prod.
The present invention treats the foot-soaking liquid of callus, and its action principle is as follows:
Callus is because of the long-term pressurized in affected part or friction, local QI-blood circulation retardance, add skin lose battalion and occur skin keratin hypertrophy thickening and formed, when immunity of organisms lowly cannot carry out normal metabolism, help it to recover normal metabolic function by the external preparation with blood circulation promoting regulates qi effect, and supplement required corresponding nutrient substance can symptom management deterioration or make it restore to normal condition.
Spica Prunellae extract not only has detumescence, hard masses softening and resolving effect, also there is good blood pressure lowering, blood sugar lowering, antibacterial, antiviral and immunosuppressive action, the every 100mg of its hypoglycemic action intensity is equivalent to 22.6u insulin, its to some because pathology damage that immunologic process causes has the effect for the treatment of.
Flos Osmanthi Fragrantis extract not only has effect of the broken knot of cold expelling, and also have anti-inflammation, Inhibiting α-glucosidase activity and hypoglycemic activity, itself and Spica Prunellae share the effect that can strengthen both.
The circulation of qi promoting of Rhizoma Sparganii removing blood stasis, removing food stagnancy pain relieving, focus on loose blood agglomeration, its extract has accelerates blood circulation and antiinflammatory action, Radix Et Rhizoma Nardostachyos, Fructus Akebiae promoting the circulation of QI, invigorate blood circulation, regulating QI to relieve pain, focus on loose depressed, Radix Et Rhizoma Nardostachyos extract can prevent the skin both dysfunction caused because of extruding, its by anti-inflammation, diastole smooth muscle, expand blood capillary, improve microcirculation to impel ulcer healing.Fructus Akebiae extract has good anti-inflammatory efficacy, and this research finds to be made an addition in the prescription of foot-soaking liquid of the present invention, has significant efficacy enhancing and toxicity reducing effect.
Propolis not only has effect of softening keratinized tissue, pain relieving, trace element also containing abundant multivitamin, aminoacid, needed by human in its extract, its nutrition providing sufficient for not only can be foot tissue in foot-soaking liquid of the present invention, can also promote the absorption of effective ingredient.
Galla Chinensis has arresting sweating hemostasis, removing dampness sore, detoxicating functions, and be the good medicine for the treatment of Skin wet and rotten, carbuncle sore tumefacting virus, its extract has the antibacterial action of wide spectrum, and it is for strengthening ulcer healing effect in foot-soaking liquid prescription of the present invention.
A kind of foot-soaking liquid for the treatment of callus of the present invention and preparation method thereof has the following advantages and beneficial effect:
(1) the present invention is through a large amount of experiment of inventor and research, draw a kind of foot-soaking liquid for the treatment of callus, determine described foot-soaking liquid best composition and proportioning thereof, namely Spica Prunellae, Flos Osmanthi Fragrantis, Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos, propolis, Galla Chinensis with special ratios with the use of, generation can be worked in coordination with and treat callus significantly, improve ulcer and the hypoglycemic effect of blood pressure lowering;
(2) foot-soaking liquid gentleness of the present invention, safety, be applicable to the daily health caring of diabetics;
(3) preparation method of foot-soaking liquid of the present invention is simple, easy to operate, and effective component extraction rate is high, is applicable to large-scale production.
Detailed description of the invention
Below with reference to specific embodiment, the present invention will be further described.
The preparation of embodiment 1 foot-soaking liquid of the present invention
A kind of foot-soaking liquid for the treatment of callus of the present embodiment, its active component comprises the raw material of following weight:
Spica Prunellae 30g, Flos Osmanthi Fragrantis 20g, Rhizoma Sparganii 20g, Fructus Akebiae 20g, Radix Et Rhizoma Nardostachyos 20g, propolis 15g, Galla Chinensis 10g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 20 minutes at 145 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 660g, continue decoction 30 minutes after water boils, then the vinegar adding 300g decocts 18 minutes, stop heating, to stay in pot vexed 7 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 80%, 35 minutes are extracted at 65 DEG C of ultrasound wave (power is 150W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:10;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 65 DEG C, ultrasound wave (power is 150W) extracts 25 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 2/5 of original volume, obtains described foot-soaking liquid A1.
The preparation of embodiment 2 foot-soaking liquid of the present invention
A kind of foot-soaking liquid for the treatment of callus of the present embodiment, its active component comprises the raw material of following weight:
Spica Prunellae 15g, Flos Osmanthi Fragrantis 13g, Rhizoma Sparganii 13g, Fructus Akebiae 13g, Radix Et Rhizoma Nardostachyos 13g, propolis 10g, Galla Chinensis 8g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 25 minutes at 135 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 390g, continue decoction 25 minutes after water boils, then the vinegar adding 156g decocts 15 minutes, stop heating, to stay in pot vexed 6 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 70%, 30 minutes are extracted at 60 DEG C of ultrasound wave (power is 150W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:8;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 60 DEG C, ultrasound wave (power is 150W) extracts 20 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 1/2 of original volume, obtains described foot-soaking liquid B1.
The preparation of embodiment 3 foot-soaking liquid of the present invention
A kind of foot-soaking liquid for the treatment of callus of the present embodiment, its active component comprises the raw material of following weight:
Spica Prunellae 25g, Flos Osmanthi Fragrantis 17g, Rhizoma Sparganii 17g, Fructus Akebiae 17g, Radix Et Rhizoma Nardostachyos 17g, propolis 12g, Galla Chinensis 8g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 15 minutes at 155 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 561g, continue decoction 30 minutes after water boils, then the vinegar adding 255g decocts 16 minutes, stop heating, to stay in pot vexed 7 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 75%, 35 minutes are extracted at 65 DEG C of ultrasound wave (power is 150W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:10;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 65 DEG C, ultrasound wave (power is 150W) extracts 25 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 3/10 of original volume, obtains described foot-soaking liquid C1.
The preparation of embodiment 4 foot-soaking liquid of the present invention
A kind of foot-soaking liquid for the treatment of callus of the present embodiment, its active component comprises the raw material of following weight:
Spica Prunellae 35g, Flos Osmanthi Fragrantis 24g, Rhizoma Sparganii 24g, Fructus Akebiae 24g, Radix Et Rhizoma Nardostachyos 24g, propolis 19g, Galla Chinensis 15g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 20 minutes at 140 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 792g, continue decoction 30 minutes after water boils, then the vinegar adding 432g decocts 18 minutes, stop heating, to stay in pot vexed 7 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 80%, 35 minutes are extracted at 65 DEG C of ultrasound wave (power is 200W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:10;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 65 DEG C, ultrasound wave (power is 200W) extracts 25 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 1/2 of original volume, obtains described foot-soaking liquid D1.
The preparation of embodiment 5 foot-soaking liquid of the present invention
A kind of foot-soaking liquid for the treatment of callus of the present embodiment, its active component comprises the raw material of following weight:
Spica Prunellae 45g, Flos Osmanthi Fragrantis 34g, Rhizoma Sparganii 34g, Fructus Akebiae 34g, Radix Et Rhizoma Nardostachyos 34g, propolis 28g, Galla Chinensis 22g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 20 minutes at 155 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 1224g, continue decoction 35 minutes after water boils, then the vinegar adding 714g decocts 20 minutes, stop heating, to stay in pot vexed 8 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 85%, 40 minutes are extracted at 70 DEG C of ultrasound wave (power is 200W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:12;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 70 DEG C, ultrasound wave (power is 200W) extracts 30 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 2/5 of original volume, obtains described foot-soaking liquid E1.
Comparative example 1
This comparative example foot-soaking liquid, its active component comprises the raw material of following weight:
Spica Prunellae 30g, Flos Osmanthi Fragrantis 20g, Rhizoma Sparganii 20g, Radix Et Rhizoma Nardostachyos 20g, propolis 15g, Galla Chinensis 10g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 20 minutes at 145 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 440g, continue decoction 30 minutes after water boils, then the vinegar adding 200g decocts 18 minutes, stop heating, to stay in pot vexed 7 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 80%, 35 minutes are extracted at 65 DEG C of ultrasound wave (power is 150W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:10;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 65 DEG C, ultrasound wave (power is 150W) extracts 25 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 2/5 of original volume, obtains described foot-soaking liquid A2.
Comparative example 2
This comparative example foot-soaking liquid, its active component comprises the raw material of following weight:
Spica Prunellae 11g, Flos Osmanthi Fragrantis 10g, Rhizoma Sparganii 10g, Fructus Akebiae 10g, Radix Et Rhizoma Nardostachyos 10g, propolis 7g, Galla Chinensis 4g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 25 minutes at 135 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 300g, continue decoction 25 minutes after water boils, then the vinegar adding 120g decocts 15 minutes, stop heating, to stay in pot vexed 6 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 70%, 30 minutes are extracted at 60 DEG C of ultrasound wave (power is 150W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:8;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 60 DEG C, ultrasound wave (power is 150W) extracts 20 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 1/2 of original volume, obtains described foot-soaking liquid B2.
Comparative example 3
This comparative example foot-soaking liquid, its active component comprises the raw material of following weight:
Spica Prunellae 50g, Flos Osmanthi Fragrantis 40g, Rhizoma Sparganii 34g, Fructus Akebiae 44g, Radix Et Rhizoma Nardostachyos 38g, propolis 27g, Galla Chinensis 22g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) first the Galla Chinensis of above-mentioned weight is cleaned, remove impurity, fry 20 minutes at 155 DEG C;
(2) Rhizoma Sparganii of above-mentioned weight, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, remove impurity and be placed in saucepan, add the water boil of 1392g, continue decoction 35 minutes after water boils, then the vinegar adding 812g decocts 20 minutes, stop heating, to stay in pot vexed 8 hours, dry;
(3) by cleaning, the Spica Prunellae of dry above-mentioned weight, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 85%, 40 minutes are extracted at 70 DEG C of ultrasound wave (power is 200W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:12;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 70 DEG C, ultrasound wave (power is 200W) extracts 30 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, concentrate drying, to 2/5 of original volume, obtains described foot-soaking liquid E2.
Comparative example 4
Spica Prunellae 30g, Flos Osmanthi Fragrantis 20g, Rhizoma Sparganii 20g, Fructus Akebiae 20g, Radix Et Rhizoma Nardostachyos 20g, propolis 15g, Galla Chinensis 10g.
The preparation method of above-mentioned foot-soaking liquid is as follows:
(1) Spica Prunellae of clean, dry above-mentioned weight, Flos Osmanthi Fragrantis, Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos, propolis, Galla Chinensis are pulverized respectively, mixed, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 80%, 35 minutes are extracted at 65 DEG C of ultrasound wave (power is 150W), sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:10;
(2) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, at 65 DEG C, ultrasound wave (power is 150W) extracts 25 minutes, sucking filtration while hot, obtains filtrate II and filtering residue II;
(3) filtrate I and filtrate II are merged, concentrate drying, to 2/5 of original volume, obtains described foot-soaking liquid A3.
Embodiment 6 efficacy assessments
One, experiment purpose
Evaluated by relative analysis, foot-soaking liquid A1, B1, C1, D1, E1 obtained by Evaluation operation example 1 ~ 5 are to the improvement of callus and therapeutic efficiency.
Two, experimental technique
1, clinical experiment evaluation
Collection has skin ulcer, does not have clinical infection sign, and the patient occurring callus totally 300 examples, wherein man 170 example, female 100 example, 41 ~ 80 years old age, average (56.0 ± 7.6) year; Diabetic duration 1-22, in average (11.0 ± 5.5) year, is divided into 10 groups at random, often organizes 30 examples, and through scheduling to last the objective clinical observation in March, patient, all without severe cardiac, liver, kidney and hematologic disease, utilizes own control to study curative effect.
2, experimental technique
Using A1, B1, C1, D1, E1 group foot-soaking liquid as experiment product, commercially availablely there is the foot-soaking liquid of similar effect for matched group with A2, A3, B2, E2 group and certain, in foot-soaking liquid, the water of 15 times amount 50 DEG C is added before using, both feet soak more than 30 minutes, duration of test, patient coordinates normal insulinize on guarantee diabetic diet basis, makes glycemic control between 7 ~ 9mmol/L.
3, evaluation methodology
Evaluation criteria is with reference to the Standardization of diagnosis and curative effect of traditional Chinese medical science callus.Cure: skin lesion disappears completely, skin color recovers normal, and ulcer surface heals completely; Effective: skin lesion deliquescing is thinning, skin color improves, and ulcer surface reduces more than 70%; Effective: skin lesion deliquescing is thinning, skin color improves, and ulcer surface reduces more than 30%.
After testing front and test, observation index comprises following aspect:
(1) safety indexes: the large conventional and electrocardiogram of blood pressure, pulse, blood, urine, excrement three, liver, kidney brake check.
(2) untoward reaction is observed: skin allergy.
Three, experimental result
End value is improved in table 1 callus affected part
In trier's clinical trial process, use the patient blood glucose of A1, B1, C1, D1, E1 group foot-soaking liquid, monitoring of blood pressure value all lower than not participating in the front daily monitor value of test, and remain in normal range, wherein use the patient of A1, D1, E1 group foot-soaking liquid, blood sugar decreasing effect is better.Use the patient of A1, B1, C1, D1, E1, A3, B2 group foot-soaking liquid to try out in process and be showed no obvious adverse reaction; Use in the patient of A2 group foot-soaking liquid and occur the slight anaphylaxis person of 6 example, other are without significant change; Use in the patient of E2 group foot-soaking liquid and occur the slight anaphylaxis person of 3 example, other are without significant change; Use in the patient of certain commercially available prod and occur the slight anaphylaxis person of 8 example, other are without significant change.
Interpretation of result: experimental group foot-soaking liquid (A1 as can be seen from Table 1, B1, C1, D1, E1) with matched group foot-soaking liquid (A2, A3, B2, E2) and certain commercially availablely there is similar effect foot-soaking liquid all have treatment in various degree and improvement result to the skin lesion in trier's callus affected part and ulcer, but experimental group foot-soaking liquid (A1, B1, C1, D1, E1) to the treatment of callus and ulcer with improve successful and be better than matched group foot-soaking liquid (A2, A3, B2, and certain commercially available effect with similar effect foot-soaking liquid E2), and use the patient blood glucose of experimental group foot-soaking liquid, blood pressure has the effect of reduction, wherein effect of experimental group foot-soaking liquid is by B1, C1, A1, D1, E1 is increasing trend, but D1, effect of E1 group increases and not obvious, therefore angularly consider that the prescription of preferred A1 group foot-soaking liquid and ratio thereof are best of breed from economic worth.In addition, can find out that from table 1 and adverse reaction monitoring A1 group foot-soaking liquid is to the treatment of callus and ulcer with improve successful and be better than A2 group and A3 group, and use the patient of A2 group foot-soaking liquid to occur slight anaphylaxis, illustrate that the Fructus Akebiae containing specific ratio in foot-soaking liquid prescription of the present invention plays significant efficacy enhancing and toxicity reducing effect in prescription thus, and the preparation method of foot-soaking liquid of the present invention can significantly improve the effective ingredient dissolution rate of this foot-soaking liquid.
To sum up, foot-soaking liquid of the present invention has and treats callus significantly, improves ulcer and the hypoglycemic effect of blood pressure lowering.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (6)
1. treat a foot-soaking liquid for callus, it is characterized in that, the active component of described foot-soaking liquid comprises the raw material of following weight parts:
Spica Prunellae 15 ~ 45 parts, Flos Osmanthi Fragrantis 13 ~ 34 parts, Rhizoma Sparganii 13 ~ 34 parts, Fructus Akebiae 13 ~ 34 parts, Radix Et Rhizoma Nardostachyos 13 ~ 34 parts, propolis 10 ~ 28 parts, Galla Chinensis 8 ~ 22 parts.
2. foot-soaking liquid according to claim 1, is characterized in that, the active component of described foot-soaking liquid comprises the raw material of following weight parts:
Spica Prunellae 25 ~ 35 parts, Flos Osmanthi Fragrantis 17 ~ 24 parts, Rhizoma Sparganii 17 ~ 24 parts, Fructus Akebiae 17 ~ 24 parts, Radix Et Rhizoma Nardostachyos 17 ~ 24 parts, propolis 12 ~ 19 parts, Galla Chinensis 8 ~ 15 parts.
3. foot-soaking liquid according to claim 1 and 2, is characterized in that, described Spica Prunellae is the herb with mature fruit cluster.
4. foot-soaking liquid according to claim 1 and 2, is characterized in that, described Flos Osmanthi Fragrantis is silver-colored osmanthus.
5. the preparation method of the foot-soaking liquid according to any one of Claims 1 to 4, is characterized in that, comprises the steps:
(1) first Galla Chinensis is cleaned, remove impurity, fry 15 ~ 25 minutes at 135 DEG C ~ 155 DEG C;
(2) Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos are cleaned, removing impurity is placed in saucepan, add the water boil of Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos three gross weight 10 ~ 12 times amount, decoction 25 ~ 35 minutes are continued after water boils, add again Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos three gross weight 4 ~ 7 times amount vinegar decoct 15 ~ 20 minutes, stop heating, to stay in pot vexed 6 ~ 8 hours, dry;
(3) by cleaning, dry Spica Prunellae, Flos Osmanthi Fragrantis and propolis and the Galla Chinensis handled well through step (1) and step (2), Rhizoma Sparganii, Fructus Akebiae, Radix Et Rhizoma Nardostachyos pulverize respectively, mix, obtain mixture, mixture is placed in ultrasonic extraction device, add the ethanol of 70% ~ 85%, 60 DEG C ~ 70 DEG C ultrasonic extraction 30 ~ 40 minutes, sucking filtration while hot, obtains filtrate I and filtering residue I, and the solid-liquid ratio of ethanol and mixture is 1:8 ~ 12;
(4) filtering residue I is added the ethanol with same concentrations in step (3) and volume, be placed in ultrasonic extraction device, ultrasonic extraction 20 ~ 30 minutes at 60 DEG C ~ 70 DEG C, sucking filtration while hot, obtains filtrate II and filtering residue II;
(5) filtrate I and filtrate II are merged, namely concentrate drying to 3/10 ~ 1/2 times of original volume obtains described foot-soaking liquid.
6. the preparation method of foot-soaking liquid according to claim 5, is characterized in that, described hyperacoustic power is 150 ~ 200W.
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| CN110694022A (en) * | 2019-10-25 | 2020-01-17 | 罗令 | A patch for treating sole heart with blood pressure and blood lipid lowering effects, and its preparation method |
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