CN105287817B - A kind of relieving mood loosens decompression, relieving mental strain and helping sleep, eliminates herbal composite tired out - Google Patents
A kind of relieving mood loosens decompression, relieving mental strain and helping sleep, eliminates herbal composite tired out Download PDFInfo
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Abstract
The invention discloses for relieving mood and/or loosening decompression and/or relieving mental strain and helping sleep and/or eliminating herbal composite tired out, according to the total volume meter of the herbal composite, the composition includes: the sandalwood essential oil of 25-30 volume %；The semen ziziphi spinosae essential oil of 15-20 volume %；The ganoderma lucidum essential oil of 15-25 volume %；The Fructus Perillae quintessence oil of 15-20 volume %；The lemon of 15-18 volume %；Wherein, the sum of each component is 100 volume % in the composition.The invention further relates to application of the herbal composite in cosmetics.
Description
Technical field
The present invention relates to field of natural medicinal chemistry and cosmetic field, and in particular to one kind is used for relieving mood, loosens
Decompression, relieving mental strain and helping sleep eliminate herbal composite tired out, the preparation method of the herbal composite and application.
Background technique
With the development and the accelerating rhythm of life of society, " tired " has become the common fault of society.In U.S.'s disease control
The heart (CDC) is referred to as chronic fatigue syndrome.Fatigue belongs to Social Medicine scope, ought to cause to include the social each of medical field
The extensive reproduction on boundary, Japan are formally classified as fatigue one kind of occupational disease.There are about 35% or more in World Health Organization's investigation whole world
People it is in a state of fatigue.Foreign data is shown, in general population, continues the phenomenon of fatigue with the presence of 5%~20% people；Just
Fatigue is one of most common symptom in grade medical treatment, has 5%~20% patient main suit for fatigue, separately there is 5%~20% trouble
Person thinks that fatigue is their important simultaneous phenomenons.So fatigue may be a kind of protectiveness irritability physiological reaction, also may
It is the pathologic reaction that internal organs organ loses non-equilibrium stable state, it alerts body and needs to handle, needs to adjust.
A subjective feeling symptom of the fatigue as body is that body physical strength or energy weaken or loses a kind of complicated
The embodiment of physiology, psychology and pathological phenomenon.Therefore, fatigue can see Healthy People, can also be used as a disease, see many
The other diseases of corporality, psychological mental disease and human body.Fatigue performance include: it is tired out, limb aching pain is uncomfortable, sleep is disorderly
Unrest, emotional maladjustment (amnesia, emotional, fidgety, depressed, distraction, thinking be not quick) etc..Not only in this, fatigue can also
So that work and various aspects ability is declined > 30%, and will appear the inferior health performance even psychosomatic in terms of many bodies and minds, such as
Bronchitis, asthma, nonspecific colonitis, heart disease, palpitaition, nettle rash, essential hypertension, peptic ulcer, stomachache,
Insomnia etc., seriously affects health.
Chinese medicine thinks that fatigue has various performances, such as: confused tired (insobriety), sleepy (a certain position of human body is uncomfortable
Sense), lazy tired (being reluctant activity), mind it is tired it is (listless), be tired of tired (unhappy irritable), soft tired (body is weak uncomfortable), burnout (lazy nothing
Mind), tired (sleepy and tired), dusk tired (dizzy lazy move), mind tired (insobriety is easily forgotten), idle (powerlessly keeping forging ahead), (few power out of strength
Gas), power is insufficient (unable to do what one wishes), neck sour (neck acid is heavy), shoulder sour (shoulder acid is heavy) etc..Wherein, it and is allocated as partially empty and inclined
It is two kinds real.Since tension pressure causes liver and gallbladder fire to be contained, stagnation of liver qi, and worry impairing spleen person are relatively real, and performance is with unhappy irritable easy
Anger, limb aching pain is heavy, based on vexed insomnia dreaminess.
The cause of disease and pathogenesis of fatigue are unknown, but abnormal, psychological and social factor the exception of immune function is to cause
The basic reason that fatigue occurs.Reinforce the immune function of body, improve psychological quality with the ability to bear for adapting to society to be to pass
Important.For fatigue, for doctor trained in Western medicine because of its objective basis without obvious pathological change, effective prevention and treatment measure is limited, and
" preventiveing treatment of disease " theory of Chinese medicine is but perfectly in harmony with it, and Chinese medicine emphasizes diagnosis and treatment and comprehensive measure, and control efficiency pole has
Advantage.
Studies have shown that being aromatotherapy for one of mode of tired effective prevention.According to a domestic Xiang Fang in 2011
Fragrant therapy market real example survey report is shown: aromatotherapy has as a kind of pure natural, Small side effects and loosens body and mind, alleviates
The method of pressure effect has the very big market demand.
Aromatotherapy is long-standing.Its definition is one and is reached health guarantor using plants essential oil (essential oil)
Strong and beauty art and science.It is the elegant fragrance come out of fragrance ingredient that volatilized by fragrance, is sucked through olfactory organ
It in human body, or directly contacts with skin surface and generates apparent psychology, physiological reaction, to reach health care, cure the disease, beauty
Purpose.For thousands of years, Chinese medicine utilizes the fragrance ingredient of natural aromatic plant, passes through a variety of ways such as massage, shower, outer painting, Wen Xiang
Diameter gets rid of illness and health-care effect to human body generation.Virtue is treated in China, and accurate saying is that " fragrant medication " is more definite.With west
The difference of aromatotherapy is that fragrant medication followed is the theoretical system of traditional Chinese medicine, and dosage form and application method are more various, no
Few aromatic drug enters decoction application mostly, therefore fails to be formed " essential oil " such a concentrate very much and the transmitting carrier of characteristic.But
The treatment of Chinese style virtue is compared with Western-style, is had theoretical system, specific ingredient, application mode, the difference of prescription theory, is more in fact
" Chinese style " that suitable compatriots use, " Chinese Fragrant ".
Therefore, the present invention develops relieving mood, loosens decompression, calms the nerves for the performance of above-mentioned " inclined full mold " tired crowd
Herbal composite tired out is eliminated in sleeping.It is intended under the theoretical direction of " preventiveing treatment of disease ", evades the side effect and effect of pharmaceutical intervention
Fruit is uncertain, selects the combination of Chinese style incense drug, by the apparent effect of experimental verification, illustrates mechanism, and can have product abundant
Form has high application and popularization value.
Summary of the invention
It is well known in the art that excessive or too strong work, work etc., cause body tired out, neuromuscular is tight,
Or have hectic fever sweating, notably the swollen discomfort of shoulder neck four limbs acid, sleepy not relax but be difficult to fall asleep or slept shallow；Pressure load is big, thinks
Consider overweight, easily anxious nervous or irritability.Chinese medicine thinks, this is because overwork wasting QI-blood, worry impairing spleen, or have liver and gallbladder fire concurrently
It contains, stagnation of QI due to depression of the liver blood stasis, so that above-mentioned discomfort, occur in limb muscle dystrophy, the insufficiency of heart and spleen, while local stagnation of QI-blood.
It is recognized based on above-mentioned theory, the present invention is prepared for a kind of new using santal, semen ziziphi spinosae, ganoderma lucidum, purple perilla and lemon
Herbal composite.Specifically, in formula of the invention, the stagnant qi and blood of santal qi-regulating, the unobstructed stasis of blood, the nourishing heart peace of semen ziziphi spinosae
Mind is altogether monarch drug in a prescription；Ganoderma lucidum warms up the five internal organs, and mind sedate of diving, is ministerial drug；Burnt, row lung qi during purple perilla is warm, is adjutant；Lemonene sweet gas breath
The pleasant mind, relieving mood at once, to make medicine.
Santal [latin name] Santalum album linn pungent-warm, returns spleen stomach, cardiopulmonary warp, function promoting the circulation of qi middle benefit gas, appetizing stop
Bitterly.Essentials of Matea Medica " adjusts spleen and lung, sharp chest diaphragm is qi-regulating key medicine "；Sandalwood essential oil can be with the anxiety and anxiety of calm nerves.
Semen ziziphi spinosae [latin name] Ziziphus jujuba Mill.var.spinosa returns liver, the heart, the spleen channel, antitoxic heart-soothing and sedative,
" Bencao Jingshu ": " semen ziziphi spinosae, real acid is flat, and benevolence is then and sweet.Special tonifying liver gallbladder, is also amusing again.Ripe then fragrant, fragrance enters spleen, therefore can return
Spleen.Courage can be mended, therefore can warm gallbladder.The gas phase of mothers and sons is logical, thus also main dysphoria, vexatious must not sleep ".
Ganoderma lucidum [latin name] Ganoderma Lucidum (Leyss.ex Fr.) Karst, Gan Ping, return heart, the spleen channel, effect
Replenishing qi and blood, tranquilizing mind, " Chinese tradition tonic tonic ": " mental-tranquilization, tonifying lung benefit liver ", " medicinal plants in China illustrated handbook " " controls mind
Through weak, insomnia, the chronic diseases such as indigestion ", modern pharmacological studies have shown that there is immunoregulation effect, and there is antioxygen to be turned into
With；
Purple perilla [latin name] erilla frutescens (L.) Britt.: return lung, taste warp, inducing diaphoresis promoting the circulation of qi is in, " this
Grass, which converges, to be sayed ": " purple perilla, cold dispelling gas, clearing lung-heat gas, wide middle gas, miscarriage prevention gas, lower knot gas, resolving sputum gas are the god's medicine for controlling gas." " medicine
Productization justice ": " perilla leaf, for the object of generation.Pungent-warm can dissipate, gas Bao Nengtong, and taste is thin to be given vent to."
Lemon [latin name] Citrus limon: nature and flavor acid sweet and cool-natured attaches to the lung and stomach meridians, the function for the stomach function regulating that promotes the production of body fluid to quench thirst；Lemon extract
Oil has calm gentle function.
The present invention uses the composition of above-mentioned five kinds of ingredients, and regulating the flow of vital energy and dispeling melancholy, mental-tranquilization, activating microcirculation and removing stasis medicinal enable fur space between skin and muscles
Gentle relax is supported, and channels and collaterals running Shu Chi degree of having, anxiety is tired out to be dissolved.
Therefore, in one aspect of the invention, one kind is provided to be used to relieving mood and/or loosen decompression and/or calm the nerves help
It sleeps and/or eliminates herbal composite tired out, according to the total volume meter of the herbal composite, the composition includes:
The sandalwood essential oil of 25-30 volume %；
The semen ziziphi spinosae essential oil of 15-20 volume %；
The ganoderma lucidum essential oil of 15-25 volume %；
The Fructus Perillae quintessence oil of 15-20 volume %；
The lemon of 15-18 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
In one preferred embodiment, the present invention provides one kind for relieving mood and/or loosen decompression and/or
Relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the total volume meter of the herbal composite, the composition
Include:
The sandalwood essential oil of 28-30 volume %；
The semen ziziphi spinosae essential oil of 15-20 volume %；
The ganoderma lucidum essential oil of 16-22 volume %；
The Fructus Perillae quintessence oil of 15-18 volume %；
The lemon of 16-18 volume %.
In one preferred embodiment, the present invention provides one kind for relieving mood and/or loosen decompression and/or
Relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the total volume meter of the herbal composite, the composition
Include:
The sandalwood essential oil of 30 volume %；
The semen ziziphi spinosae essential oil of 20 volume %；
The ganoderma lucidum essential oil of 16 volume %；
The Fructus Perillae quintessence oil of 18 volume %；
The lemon of 18 volume %.
In one preferred embodiment, the present invention provides one kind for relieving mood and/or loosen decompression and/or
Relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the total volume meter of the herbal composite, the composition
Include:
The sandalwood essential oil of 28 volume %；
The semen ziziphi spinosae essential oil of 15 volume %；
The ganoderma lucidum essential oil of 20 volume %；
The Fructus Perillae quintessence oil of 20 volume %；
The lemon of 17 volume %.
In one preferred embodiment, the present invention provides one kind for relieving mood and/or loosen decompression and/or
Relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the total volume meter of the herbal composite, the composition
Include:
The sandalwood essential oil of 25 volume %；
The semen ziziphi spinosae essential oil of 20 volume %；
The ganoderma lucidum essential oil of 22 volume %；
The Fructus Perillae quintessence oil of 15 volume %；
The lemon of 16 volume %.
In an optional embodiment, herbal composite of the invention also includes other compositions.It is specific at one
Embodiment in, herbal composite of the invention includes dispersing stagnated hepatoqi constituents, such as rose, fingered citron, citron, thus real
The stagnant qi and blood of existing dispersing stagnated hepatoqi, the unobstructed stasis of blood.In another optional embodiment, herbal composite of the invention may include
Tranquilizing the mind is releived constituents.In a specific embodiment, composition of the invention may include agalloch eaglewood, warm up the five internal organs, and mind of diving is fixed
Will.In a specific embodiment, composition of the invention may include lavender, releive tired, pacify balance mood.?
In one specific embodiment, composition of the invention may include fish pelargonium, eliminate anxiety and tense, mitigate pressure, balance body
The heart.
In another aspect of this invention, provide a kind of herbal composite relieving mood and/or loosen decompression and/or
Relieving mental strain and helping sleep and/or eliminate it is tired out in application, according to the total volume meter of the herbal composite, the composition includes:
The sandalwood essential oil of 25-30 volume %；
The semen ziziphi spinosae essential oil of 15-20 volume %；
The ganoderma lucidum essential oil of 15-25 volume %；
The Fructus Perillae quintessence oil of 15-20 volume %；
The lemon of 15-18 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
In another aspect of this invention, a kind of cosmetics are provided, which contains herbal composite and makeup
Acceptable excipient on product, according to the total volume meter of the herbal composite, the herbal composite includes:
The sandalwood essential oil of 25-30 volume %；
The semen ziziphi spinosae essential oil of 15-20 volume %；
The ganoderma lucidum essential oil of 15-25 volume %；
The Fructus Perillae quintessence oil of 15-20 volume %；
The lemon of 15-18 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
In another aspect of this invention, one kind is provided for relieving mood and/or loosens decompression and/or relieving mental strain and helping sleep
And/or herbal composite tired out is eliminated, according to the total volume meter of the herbal composite, the composition includes:
4.746% phellandrene, 1.472% firpene, 1.965% d-limonen, 7.879% left-handed limonene, 3.390% eucalyptus oil
Element, 8.842% linalool, 2.114% rose oxide, 1.922% benzyl carbinol, 1.670% formic acid -2- benzene second rouge, 2.759% dragon
Brain, 1.844% terpinol, 2.790% citronellol, 1.585% citral, 1.640% nerol, 1.954% geranyl acetate,
Alkene by 1.562% beta waves, 1.479% heptane, 1.989% tiglic acid 2- phenyl chlorocarbonate, 16.997% cis--santalol,
5.065% bergamot alcohol, 9.004% trans--santalol.
In a specific embodiment, the cosmetics are skin preparations for extenal use.
In some embodiments, with the total weight of the skin preparations for extenal use, the dosage of the herbal composite is
0.001-20% (w/w), preferably 0.001-10% (w/w), more preferably 0.01-5% (w/w), most preferably 0.01-2%
(w/w)。
Detailed description of the invention
Fig. 1 shows the TIC X-Y scheme of " Chinese Fragrant " embodiment 2.
Fig. 2 shows the TIC three-dimensional figure of " Chinese Fragrant " embodiment 2.
Fig. 3 shows the TIC figure of " Chinese Fragrant " embodiment 2.
Specific embodiment
The present invention is described to be combined to obtain by sandalwood essential oil, semen ziziphi spinosae essential oil, ganoderma lucidum essential oil, Fructus Perillae quintessence oil, lemon
A kind of herbal composite.Verified through related efficacy, herbal composite of the invention have relieving mood, loosen decompression,
Relieving mental strain and helping sleep eliminates effect tired out.Therefore, herbal composite of the invention can be used as functional additive and be added to makeup
In product, having the function that releive pressure and/or is relieved fatigue.
Sandalwood essential oil of the present invention, semen ziziphi spinosae essential oil, ganoderma lucidum essential oil, Fructus Perillae quintessence oil, lemon extract are not directed in document
The herbal composite that oil combination obtains, does not refer to yet and being added in cosmetics as functional additive.Therefore, the present invention is first
It is secondary to propose the Chinese herbal medicine combination combined with sandalwood essential oil, semen ziziphi spinosae essential oil, ganoderma lucidum essential oil, Fructus Perillae quintessence oil, lemon
Object, the herbal composite have unexpected technical effect of the present invention, relieving mood and/or can loosen
Decompression and/or relieving mental strain and helping sleep and/or elimination are tired out.
In cosmetic applications, herbal composite of the invention can be applied to various forms.For example, in of the invention
It is any applied to human body that herbal-composition can be applied to mildy wash, toner, lotion, cream, gel, facial mask, shower cream etc.
The dosage form of skin.
Below with reference to specific embodiment, the present invention is further explained.It should be appreciated, however, that these embodiments are only used for
It is bright the present invention and be not meant to limit the scope of the invention.The test method of actual conditions is not specified in the following example, usually
According to normal conditions, or according to the normal condition proposed by manufacturer.Unless otherwise indicated, all percentage and number be by weight
Meter.
The raw material used in embodiment 1-3 is commercially available sandalwood essential oil, commercially available semen ziziphi spinosae essential oil, commercially available ganoderma lucidum essential oil, commercially available
Fructus Perillae quintessence oil, commercially available lemon.Also, the ratio in comparative example and embodiment 1-3 is percent by volume.
Sandalwood essential oil used in the present invention, semen ziziphi spinosae essential oil, ganoderma lucidum essential oil, Fructus Perillae quintessence oil, lemon are purchased from graceful
Family name (Shanghai) flavors and fragrances Co., Ltd.
Comparative example: the screening of herbal composite
Theoretical prescription: according to " monoblock type maintenance " principles of formulating prescriptions of innovative Chinese Fragrant, it is comprehensive embody effect and
Fragrance, first selection have " monarch " ingredient for relaxation effect of releiving, and consider the stereovision of fragrance, obtain following optional
Prescription scheme:
Prescription 1: press santal: semen ziziphi spinosae: ganoderma lucidum=30:20:16 volume ratio calculates under room temperature ventilation state
The drop number of essential oil needed for above-mentioned, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly, it is spare.
Prescription 2: santal: semen ziziphi spinosae: ganoderma lucidum: purple perilla=30:20:16:18 volume ratio is pressed, in room temperature ventilation state
Under, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly, it is spare.
Prescription 3: santal: semen ziziphi spinosae: ganoderma lucidum: lemon=30:20:16:18 volume ratio is pressed, in room temperature ventilation state
Under, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly, it is spare.
Prescription 4: pressing santal: semen ziziphi spinosae: ganoderma lucidum: purple perilla: lemon=30:20:16:18:18 volume ratio, logical in room temperature
Under wind state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly,
It is spare.
Above-mentioned prescription is carried out to hear fragrant test, is tested to the hobby sense of fragrance and the instant impression loosened of releiving.Method
Are as follows: 15 subjects (25-50 years old, health is without essential oil or champignon allergies) are chosen, inform that test first 12 hours can not
Smoke, take in maror and drink drinks, the drink containing pungents such as caffeines.In mood tranquility, Yu Gu
Fixed quiet airspace, successively open 4 prescriptions essential oil bottle cap, carry out smelling, judgement immediately to the hobby sense of fragrance with
And whether Wen Xianghou there is instant refreshing oneself to rouse oneself impression.It counts each one favorite fragrance prescription and most releives and loosen
Immediately the prescription experienced, as a result such as following table.
| Fragrance hobby sense | It releives and loosens instant impression | |
| Prescription 1 | 1 | 1 |
| Prescription 2 | 2 | 3 |
| Prescription 3 | 5 | 2 |
| Prescription 4 | 7 | 9 |
In upper table, the scoring the high then to indicate better to the hobby of fragrance, and releiving, it is also better to loosen impression immediately.As it can be seen that group
The preference degree of the either blending of side 4, the instant impression loosened of releiving all are substantially better than its excess-three prescription, therefore, select prescription 4
It is tested into next step.
Embodiment 1: the preparation of herbal composite
Sandalwood essential oil 30%, semen ziziphi spinosae essential oil 20%, ganoderma lucidum essential oil 16%, Fructus Perillae quintessence oil 18%, lemon 18% are taken,
Under room temperature ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper,
It rocks uniformly, it is spare.
Embodiment 2: the preparation of herbal composite
Take sandalwood essential oil 28%, semen ziziphi spinosae essential oil 15%, ganoderma lucidum essential oil 20%, Fructus Perillae quintessence oil 20%, lemon 17%；
Under room temperature ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper,
It rocks uniformly, it is spare.
Embodiment 3: the preparation of herbal composite
Sandalwood essential oil 25%, semen ziziphi spinosae essential oil 22%, ganoderma lucidum essential oil 22%, Fructus Perillae quintessence oil 15%, lemon 16% are taken,
Under room temperature ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper,
It rocks uniformly, it is spare.
Embodiment 4: efficacy detection
Have chosen 120 student enrollment, wherein 2 group 30 of 30 people of " Chinese Fragrant " example 1 group, " Chinese Fragrant " embodiment
People, 3 group of 30 people of " Chinese Fragrant " embodiment, 30 people of blank control group.University student have passed through stringent choice before enrollment, select mark
Standard includes:
(1) age 18 is more than one full year of life；
(2) enter the preceding physical examination health of group；
(3) enter in group first 1 month without great Psychomotor test Battrey event；
(4) allergies are used without any stacte, essential oil；
(5) voluntarily receive subject, be able to cooperate and receive coherence check and sign informed consent form.
Before experiment, tester is apprised of test and can not smoke, take in maror and drink drinks, contain for first 12 hours
The drink of the pungents such as caffeine.Test in one week should not strenuous exercise, stay up late, be engaged in the work excessive to Psychological stimulation
It is dynamic.
The daily 19:00-20:00 of fragrant experimental selection is heard as the fragrant time is heard, and hearing the fragrant period is 7 days.Test saliva sample
Acquisition be divided into twice, acquisition for the first time first time hear it is fragrant before carry out, second of acquisition last time hear it is fragrant after carry out, will
It acquires saliva sample and carries out SIgA content in saliva and salivary cortisol measurement.
By " Chinese Fragrant " experiment group name university student tissue to the interior space of fixed quiet two isolation, around without suction
Cigarette, the crowd for spraying perfume, do not interfere with each other between experimental group.Wen Xiang starts previous hour, and researcher uses electronic atomizing machine
Essential oil is allowed to fill entire space, and sustained release fragrance during the experiment.University student Wen Xiangshi is engaged in reading, close the eyes for rest or
Other activities of releiving of person.Blank control group focuses on another equivalent interior space, using the tasteless diffusion conduct pair of pure water
According to.
And Scale and questionnaire is carried out to each group crowd before and after experiment.It is assessed using five kinds of international and domestic general mental scales
The effect of " Chinese Fragrant " for university student's physical and mental health.The scale that this research uses includes SDS- depression self-rating scale, CES-D-
Flow tune center Depression Scale, Pittsburgh Sleep Quality Index questionnaire.
Experimental result
(1) SIgA content in saliva
Experiment acquisition is divided into twice, and first time, which acquires, hears fragrant preceding progress in first time, and second of acquisition is in last time news
It is carried out after perfume (or spice).First 10 minutes of acquisition, experimental subjects is gargled with clear water.Saliva is acquired using saliva sliver collection tube, collection tube
Top be one can take out below with foraminate tubule, have a sliver to infiltrate saliva inside tubule, be centrifuged
Afterwards, saliva can flow to the bottom end of saliva sliver collection tube by aperture.Sliver is placed in sublingual about 2 minutes by experimental subjects, to cotton
Item is put back in the tubule of collection tube after saliva complete wetting, carries out centrifugation 15min using 3000 rpms of (rpm) speed,
Saliva after centrifugation flows to the bottom end of saliva sliver collection tube by aperture, collects saliva about 6ml (at least 4ml), is stored in saliva
Liquid sliver collection tube, and refrigerate immediately.The refrigerator-freezer that the saliva sliver collection tube that centrifugation finishes is sent to -20 DEG C in 30min is frozen
It deposits, is detected in 15 days.Under normal circumstances, the concentration of cortisol in blood is significantly larger than salivary cortisol concentration, because
This blood pollutes the measurement result that can seriously affect salivary cortisol, so experimenter checks saliva using naked eyes one by one after acquisition
Liquid sliver by intraoral blood whether there is or not being polluted, such as bleeding gums, by the research pair if saliva sliver is contaminated by the blood
As rejecting not meet test requirements document person, does not continue to participate in experiment, be filled by candidate research object.Using solidification enzyme linked immunological
Adsorption measurement (Enzyme linked immunosorbent assay, ELISA) kit detects SIgA content.
The following table 1 shows that Wen Xiangqian (the 0th day) and Wen Xianghou (the 7th day) experimental subjects SIgA content in saliva content (μ g/ml) become
Change.
Table 1
* p < 0.05 indicates significant difference；* p < 0.01., indicates extremely significant sex differernce.
The comparable state for delicately reflecting human body non-specific immune function of SIgA content in saliva level.Immunologic hypofunction
Crowd SIgA level also accordingly declines.Experiment shows: although pair of " Chinese Fragrant " embodiment each group SIgA content before and after hearing perfume
That significant difference is not presented according in, but as can be seen from the above table, blank control group is passed through 7 day time, SIgA content in saliva
There is downward trend, still SIgA content is in rising trend in experimental subjects saliva in " Chinese Fragrant " embodiment each group.Experiment shows
" Chinese Fragrant " embodiment each group also has the effect of the enhancing of body immunity, resistance certain.
(2) salivary cortisol
Experiment acquisition is divided into twice, and first time, which acquires, hears fragrant preceding progress in first time, and second of acquisition is in last time news
It is carried out after perfume (or spice).First 10 minutes of acquisition, experimental subjects is gargled with clear water.Saliva is acquired using saliva sliver collection tube, collection tube
Top be one can take out below with foraminate tubule, have a sliver to infiltrate saliva inside tubule, be centrifuged
Afterwards, saliva can flow to the bottom end of saliva sliver collection tube by aperture.Sliver is placed in sublingual about 2 minutes by experimental subjects, to cotton
Item is put back in the tubule of collection tube after saliva complete wetting, carries out centrifugation 15min using 3000 rpms of (rpm) speed,
Saliva after centrifugation flows to the bottom end of saliva sliver collection tube by aperture, collects saliva about 6ml (at least 4ml), is stored in saliva
Liquid sliver collection tube, and refrigerate immediately.The refrigerator-freezer that the saliva sliver collection tube that centrifugation finishes is sent to -20 DEG C in 30min is frozen
It deposits, is detected in 15 days.Under normal circumstances, the concentration of cortisol in blood is significantly larger than salivary cortisol concentration, because
This blood pollutes the measurement result that can seriously affect salivary cortisol, so experimenter checks saliva using naked eyes one by one after acquisition
Liquid sliver by intraoral blood whether there is or not being polluted, such as bleeding gums, by the research pair if saliva sliver is contaminated by the blood
As rejecting not meet test requirements document person, does not continue to participate in experiment, be filled by candidate research object.Using solidification enzyme linked immunological
Adsorption measurement (Enzyme linked immunosorbent assay, ELISA) kit detects salivary cortisol content.
The following table 2 shows Wen Xiangqian (the 0th day) and Wen Xianghou (the 7th day) experimental subjects salivary cortisol concentration (pmol/
Ml) change.
Table 2
* p < 0.05 indicates significant difference；* p < 0.01., indicates extremely significant sex differernce.
Cortisol is able to maintain that the normal physiological function of pressure state lower body；If lacking cortisol, body if, can not
Effecting reaction is made to pressure.It is chronically under pressure state, cortisol levels can be made higher, it can not normal regulating.And it tests
Show blank group after 7 days, internal concentration of cortisol has downward trend, but obvious rise is presented in embodiment 1-3 group sample
Trend is presented significant changes with own control, shows that " Chinese Fragrant " embodiment each group can promote the upper of Human Cortex's determining alcohol
It rises.
(3) scale is evaluated and tested:
This research uses depression self-rating scale, stream tune center Depression Scale, Pittsburgh Sleep scale to assess " China
It is fragrant " effect of the embodiment group for human body unhealthy emotion (spirit) state.
Depression self-rating scale contains 20 projects, is divided into 4 grades of autonomous scorings.Its main feature is that using easy, and can be quite straight
See the subjective feeling of ground reflection depressive patient.
As shown in table 3 below, experimental subjects declines nearly 9 points in 1 front and back of smelling " Chinese Fragrant " embodiment, depressed index score,
Experimental subjects is in 2 front and back of smelling " Chinese Fragrant " embodiment, and depressed nearly 5 points of the decline of index score, experimental subjects is in smelling " China
3 front and back of perfume " embodiment, depressed index score decline is more than 8 points, and depressed index score rises 3 points to blank control group after a week
It has a surplus, and " Chinese Fragrant " each embodiment group all presents extremely significant sex differernce in the two groups of controls of own control and blank control.
The result shows that " Chinese Fragrant " embodiment each group has obvious effect for the control and improvement of human body depressive emotion.
Table 3: Wen Xiangqian and Wen Xiang retarded depression Self-assessment Scale (SDS) (average mark) result
* p < 0.05 indicates significant difference；* p < 0.01., indicates extremely significant sex differernce.
Flowing tune center Depression Scale is that US National mental hygiene research institute worked out in 1977, also wide in the world at present
The general screening for general population's progress depressive symptom, is not limited to the Adult Groups being directed at the beginning of design, can also be used for blueness
Juvenile and elderly population.It includes valueless sense, loss of appetite, depressed, desperate, sleep disturbances, attention that it, which measures content,
The depressive symptoms such as difference.
And use in the assessment of stream tune center Depression Scale, conspicuousness is all presented in " Chinese Fragrant " embodiment each group in control
Difference: example 1 group depression score has dropped more than 2 points, and 2 groups of depression scores of embodiment have dropped nearly 3 points, 3 groups of depressions of embodiment
Score has dropped more than 1 point, and blank control group rises more than 1 point, demonstrates " Chinese Fragrant " A again for human body depressive emotion
Pasitive Regulation Effect of Genseng, as shown in table 4 below:
Tune center Depression Scale (average mark) result is flowed after table 4: Wen Xiangqian and Wen Xiang
* p < 0.05 indicates significant difference；* p < 0.01., indicates extremely significant sex differernce.
Pittsburgh Sleep scale can be from time for falling asleep/sleep duration/Sleep efficiency etc. Comprehensive evaluation experimental
The sleep quality of object.By 7 parts, totally 19 problems form scale, and total score is 0~21 point, and (0 point represents no sleep and asks
Topic, 21 points represent sleeping problems very serious), this test mainly uses the total score of scale, carrys out globality reflection " Chinese Fragrant "
Influence to sleep quality.
As shown in table 5 below, 2 group objects sleep index of " Chinese Fragrant " embodiment is presented in own control and blank control
Extremely significant difference, score has dropped 2 points or so after embodiment each group smelling essential oil, and blank control group rises 1 point or so,
The above results are consistent with the effect of essential oil relieving mental strain and helping sleep.
Table 5: Wen Xiangqian and Wen Xianghou Pittsburgh Sleep index scale (average mark) result
* p < 0.05 indicates significant difference；* p < 0.01, indicates extremely significant sex differernce.
Embodiment 5:3GC-MS gas-chromatography composition test
By saliva physical signs and mental scale index determining and analysis, in order to be best understood from the embodiment compound essence
Effect principle of oil, and carried out GC-MS detection.
Instrument main working parameters: LECO company, U.S. comprehensive two dimensional gas chromatography -7890 GC/ of flight time mass spectrum
Pegasus 4D GCxGC-TOFMS；First dimension chromatographic column: DB-5MS (30m × 0.25mm × 0.25 μm)；Injector temperature: 270
℃；Sample volume: 1.0 μ L；Column temperature: 60 DEG C of holding 3.0min rise to 280 DEG C with 4.0 DEG C/min, keep 2.5min；Nebulizer gas pressure
Or flow: 1.0mL/min；Split ratio: without shunting；Helium (99.999%)；Second dimension chromatographic column: DB-17MS (2m × 0.10mm
×0.10μm)；The modem period: 4.0s；Column temperature: 10 DEG C of one-dimension temperature are consistently higher than；Modem temperature: always
Higher than 15 DEG C of two-dimension temperature；Interface temperature: 270 DEG C；Ion source temperature: 220 DEG C；Ionization mode: electron bombardment ionization source；Electronics times
Increase device: 1800V；Scanning mode: 30-550amu；NIST2011 composes library.GC × GC- of two kinds of essential oils is delineated by detecting
The TIC of the TIC X-Y scheme of TOFMS, the TIC three-dimensional figure of GC × GC-TOFMS and GC × GC-TOFMS schemes.Fig. 1-3 is shown
The TIC X-Y scheme, TIC three-dimensional figure and TIC figure of " Chinese Fragrant " embodiment 2.
2 surveyed ingredient 915 of " Chinese Fragrant " embodiment, wherein similarity is greater than 600, and possibility is greater than 4000, amounts to 430
It is a, constituent analysis has been obtained by further screening (component content is greater than 1%), and the results are shown in Table 6.
Table 6: the main component of composite essential oil in embodiment 2
As can be seen that 2 sesquiterpene alcohols containing higher proportion of " Chinese Fragrant " embodiment, monoterpene alkenes chemical combination from ingredient
Object has the function of releiving and loosen, and can make one to loosen, while alcohols, aldehydes, esters, ethers have certain content, mention
High immunity, bactericidal antiphlogistic etc. have certain effect.It is more kissed with the target effect of 2 relieving mental strain and helping sleep of " Chinese Fragrant " embodiment
It closes.
Compound essential oil produced by the present invention is used for domestic chemical products, can be used as efficacy active component or as essence
Fragrance uses, and fragrant taste is sweet, and soft pleasant, application form can be mildy wash, bath oil, lotion, cream, shampoo etc.
Any dosage form that can be applied to human skin is as follows.
Embodiment 6: the preparation (including day cream and late frost) of face cream
Embodiment 7: the preparation of lotion
Embodiment 8: the preparation of facial mask
Embodiment 9: the preparation of shower cream
Claims (8)
- For relieving mood and/or loosen decompression and/or relieving mental strain and helping sleep 1. a kind of and/or eliminate herbal composite tired out, According to the total volume meter of the herbal composite, the composition is made of following components:The sandalwood essential oil of 25-30 volume %；The semen ziziphi spinosae essential oil of 15-20 volume %；The ganoderma lucidum essential oil of 15-25 volume %；The Fructus Perillae quintessence oil of 15-20 volume %；The lemon of 15-18 volume %；Wherein, the sum of each component is 100 volume % in the composition.
- 2. herbal composite as described in claim 1, which is characterized in that the composition is made of following components:The sandalwood essential oil of 28-30 volume %；The semen ziziphi spinosae essential oil of 15-20 volume %；The ganoderma lucidum essential oil of 16-22 volume %；The Fructus Perillae quintessence oil of 15-18 volume %；The lemon of 16-18 volume %.
- 3. for relieving mood and/or loosening decompression and/or relieving mental strain and helping sleep as described in claim 1 and/or eliminating tired out Herbal composite, according to the total volume meter of the herbal composite, the composition includes: 4.746% phellandrene, 1.472% firpene, 1.965% d-limonen, 7.879% left-handed limonene, 3.390% cineole, 8.842% fragrant camphor tree Alcohol, 2.114% rose oxide, 1.922% benzyl carbinol, 1.670% formic acid -2- benzene second rouge, 2.759% borneol, 1.844% pine tar Alcohol, 2.790% citronellol, 1.585% citral, 1.640% nerol, 1.954% geranyl acetate, by 1.562% beta waves Alkene, 1.479% heptane, 1.989% tiglic acid 2- phenyl chlorocarbonate, 16.997% cis--santalol, 5.065% bergamot alcohol, 9.004% trans--santalol.
- 4. the herbal composite as claimed in any one of claims 1-3 of non-treatment purpose in relieving mood and/or loosens Decompression and/or relieving mental strain and helping sleep and/or eliminate it is tired out in application.
- 5. a kind of external preparation for skin comprising herbal composite as claimed in any one of claims 1-3 as effective component Agent.
- 6. skin preparations for extenal use as claimed in claim 5, which is characterized in that described with the total weight of the skin preparations for extenal use The dosage of herbal composite is 0.001-20% (w/w).
- 7. skin preparations for extenal use as claimed in claim 6, which is characterized in that described with the total weight of the skin preparations for extenal use The dosage of herbal composite is preferably 0.001-10% (w/w).
- 8. skin preparations for extenal use as claimed in claim 7, which is characterized in that described with the total weight of the skin preparations for extenal use The dosage of herbal composite is more preferably 0.01-5% (w/w).
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| CN110664942A (en) * | 2019-11-22 | 2020-01-10 | 葛贤斌 | Chinese herbal medicine for soothing nerves and aiding sleep |
| CN111166817A (en) * | 2020-02-14 | 2020-05-19 | 江西中医药大学 | Compound essential oil for improving sleep, tranquilizing mind and relieving depression and composition thereof |
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| CN101438658A (en) * | 2008-12-24 | 2009-05-27 | 吴江市农业生态科技有限公司 | Fragrance smelling area for improving sleep |
| KR20090116513A (en) * | 2008-05-07 | 2009-11-11 | 이대희 | Method for manufacturing an aromatic for mosquito controlling |
| CN102973682A (en) * | 2011-09-06 | 2013-03-20 | 徐柔云 | Long time effective technology for treatment of insomnia |
| CN104983927A (en) * | 2015-06-15 | 2015-10-21 | 中国人民解放军第一八七中心医院 | Compound essential oil applied to meditation and calming in rehabilitation therapy of anxiety disorder |
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| KR20090116513A (en) * | 2008-05-07 | 2009-11-11 | 이대희 | Method for manufacturing an aromatic for mosquito controlling |
| CN101438658A (en) * | 2008-12-24 | 2009-05-27 | 吴江市农业生态科技有限公司 | Fragrance smelling area for improving sleep |
| CN102973682A (en) * | 2011-09-06 | 2013-03-20 | 徐柔云 | Long time effective technology for treatment of insomnia |
| CN104983927A (en) * | 2015-06-15 | 2015-10-21 | 中国人民解放军第一八七中心医院 | Compound essential oil applied to meditation and calming in rehabilitation therapy of anxiety disorder |
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