CN105287817A - Chinese herbal medicine composition used for relieving emotion, achieving relaxing and decompressing, calming nerves and aiding sleeping and eliminating fatigue - Google Patents
Chinese herbal medicine composition used for relieving emotion, achieving relaxing and decompressing, calming nerves and aiding sleeping and eliminating fatigue Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine composition used for relieving emotion and/or achieving relaxing and decompressing and/or calming nerves and aiding sleeping and/or eliminating fatigue. The composition is prepared from, by volume, 25%-30% of sandalwood essential oil, 15%-20% of wild jujube seed essential oil, 15%-25% of lucid ganoderma essential oil, 15%-20% of purple perilla essential oil and 15%-18% of lemon essential oil, wherein the total volume percentage of all the components in the composition reaches 100%. The invention further relates to application of the Chinese herbal medicine composition in cosmetics.
Description
Technical field
The present invention relates to field of natural medicinal chemistry and cosmetic field, be specifically related to a kind of for emotion of releiving, loosen decompression, relieving mental strain and helping sleep, elimination herbal composite tired out, its preparation method of this herbal composite and application.
Background technology
Along with the development of society and the quickening of rhythm of life, " tiring out " has become the common fault of society.The Center for Disease Control (CDC) is referred to as chronic fatigue syndrome.Fatigue belongs to social medicine category, ought to cause the extensive reproduction of the various circles of society comprising medical circle, and Japan is formally classified as fatigue the one of occupation disease.World Health Organization's investigation whole world about has the people of more than 35% to be in fatigue state.Foreign data shows, and in general population, has the people of 5% ~ 20% to exist and continues tired phenomenon; In primary medical care, fatigue is one of the most general symptom, has the patient main suit of 5% ~ 20% for tired, and fatigue is their important simultaneous phenomenon separately to have the patient of 5% ~ 20% to think.So fatigue may be a kind of protectiveness irritability physiological reaction, also may be the pathologic reaction that internal organs organ loses non-equilibrium stable state, its be warned body requirement process, needs adjustment.
A tired subjective feeling symptom as body is that body muscle power or energy weaken or the embodiment of the physiology of a kind of complexity of losing, psychology and pathological phenomenon.Therefore, fatigue can see Healthy People, also as a disease, can see the other diseases of many corporalities, psychological mental sickness and human body.Tired performance comprises: tired out, limb aching pain is uncomfortable, sleep disordered, emotional maladjustment (forgetful, emotional, fidgety, depressed, distraction, thinking not quick) etc.Not only in this, fatigue also can make work and each side ability decline >30%, and the subhealth state that there will be a lot of body and mind aspect shows even somatopsychic illness, such as bronchitis, asthma, nonspecific colonitis, heart disease, cardiopalmus, urticaria, essential hypertension, peptic ulcer, stomachache, insomnia etc., have a strong impact on healthy.
The traditional Chinese medical science thinks that fatigue has various performance, such as: dusk tired (insobriety), sleepy (human body a certain position sticky feeling), lazy tired (be reluctant activity), god's tired (being a cup too low), tired tired (unhappy irritable), soft tired (health is weak uncomfortable), asthenia (lazy in god), tired (sleepy and tired), dusk tired (dizzy lazy dynamic), god's tired (insobriety is easily forgotten), idle (unable keep forging ahead), weak (few strength), power deficiency (unable to do what one wishes), sore neck (cervical region acid is heavy), shoulder acid (shoulder acid is heavy) etc.Wherein, divide again work partially empty and real two kinds partially.Because tension pressure causes liver and gall fire to be contained, depression of liver-QI, the worry impairing spleen person that holds concurrently is relatively real, and show with unhappy being irritable and getting angry easily, limb aching pain is heavy, and vexed insomnia and dreamful sleep is main.
The tired cause of disease and pathogeny are failed to understand, but the exception that is abnormal, psychological and social factor of immunologic function causes the tired basic reason occurred.It is vital for strengthening the immunologic function of body, improving psychological diathesis to adapt to the ability to bear of society.For fatigue, doctor trained in Western medicine is because it is without the objective basis of obvious pathological change, and effective prevention is limited with remedy measures, and " preventive treatment of disease " theory of the traditional Chinese medical science is perfectly in harmony with it, and the traditional Chinese medical science emphasizes determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs and comprehensive measure, and prevention effect pole has superiority.
Research shows, one of the mode for tired effective prevention is aromatotherapy.Show according to the aromatotherapy market excess syndrome investigation report that 2011 domestic: aromatotherapy is little as a kind of pure natural, side effect, has the method for body and mind relaxing, relieving stress effect, has the very large market demand.
Aromatotherapy is long-standing.Its definition is art and a science using plants essential oil (essentialoil) to reach health care and beauty treatment.It is elegant fragrance out by spice volatilization fragrance ingredient, sucks in human body, or directly contact with skin surface and produce obvious psychology, physiological reaction through organum olfactorium, thus the object reaching health care, cure the disease, improve looks.For thousands of years, the traditional Chinese medical science utilizes the fragrance ingredient of natural aromatic plant, by number of ways such as massage, shower, outer painting, Wen Xiang, produces get rid of illness and health-care effect to human body.Virtue is treated in China, and saying is that " fragrant medication " is more definite accurately.Be from the different of west aromatotherapy, what fragrance medication was followed is the theoretical system of Chinese medicine, dosage form and using method are more various, and many aromatic drugs enter decoct application mostly, therefore fail to form " quintessence oil " such and concentrate and the transmission carrier of characteristic very much.But Chinese style virtue is treated and compared with Western-style, having the difference of theoretical system, concrete composition, application mode, prescription theory, is be more suitable for compatriots to use " Chinese style ", " Chinese Fragrant " in fact.
Therefore, the present invention is directed to the performance of above-mentioned " inclined full mold " tired crowd, exploitation releive emotion, loosen decompression, relieving mental strain and helping sleep, elimination herbal composite tired out.Under being intended to the theoretical direction of " preventive treatment of disease ", evade the side effect of pharmaceutical intervention and effect is uncertain, select Chinese style incense drug combine, through the distinct effect of experimental verification, illustrate mechanism, and can have a product form enriched, there is high application and popularization value.
Summary of the invention
It is well known in the art that excessively or excessively strong work, work etc., cause health tired out, neuromuscular is tight, or has hectic fever sweating, notably take on the swollen discomfort of neck extremity acid, sleepyly do not relax but be difficult to fall asleep or slept shallow; Pressure load is large, ponders over overweight, easily anxious nervous or irritability.The traditional Chinese medical science is thought, this is because overwork wasting QI-blood, and worry impairing spleen, or have liver and gall fire Sheng concurrently, stagnation of QI due to depression of the liver blood stasis, limb muscle is lost and supports, deficiency of both the heart and spleen, there is above-mentioned discomfort in local stagnation of QI-blood simultaneously.
Cognitive based on above-mentioned theory, the present invention's a kind of new herbal composite that adopted Lignum Santali Albi, Semen Ziziphi Spinosae, Ganoderma, Folium Perillae and Fructus Citri Limoniae to prepare.Specifically, the QI and blood that in formula of the present invention, Lignum Santali Albi is regulated the flow of vital energy, the unobstructed stasis of blood is stagnant, the tranquilizing by nourishing the heart of Semen Ziziphi Spinosae is monarch drug altogether; Ganoderma warms up the five internal organs, and refreshing sedate of diving is ministerial drug; Burnt during Folium Perillae is warm, row lung qi is adjuvant drug; NINGMENGXIANG sweet gas ceases the joyful mind, emotion of at once releiving, for making medicine.
The pungent temperature of Lignum Santali Albi [latin name] Santalumalbumlinn, returns taste, cardiopulmonary warp, function circulation of qi promoting warming middle-JIAO, appetizing pain relieving.Essentials of Matea Medica " adjust spleen lung, sharp chest and diaphragm is key medicine of regulating the flow of vital energy "; Sandalwood essential oil can the anxiety of calm nerves and anxiety.
Semen Ziziphi Spinosae [latin name] ZiziphusjujubaMill.var.spinosa returns liver, the heart, spleen channel, mind tranquilizing and the heart calming. " Bencao Jingshu ": " Semen Ziziphi Spinosae, real acid is flat, and core is then held concurrently sweet.Special tonifying liver gallbladder, is also amusing again.Ripe then fragrance, fragrance enters spleen, therefore can return spleen.Can courage be mended, therefore can warm gallbladder.The gas phase of mothers and sons is led to, therefore also main fidgets due to deficiency, vexatious insomnia ".
Ganoderma [latin name] GanodermaLucidum (Leyss.exFr.) Karst, Gan Ping, GUIXIN, spleen channel, effect replenishing QI and blood, tranquilizing mind, " Chinese tradition tonic tonic ": " tranquilizing by nourishing the heart, tonifying the lung the liver benefiting ", " medicinal plants in China illustrated handbook " " controls neurasthenia; insomnia, the chronic diseases such as dyspepsia ", and modern pharmacological research shows, there is immunoregulation effect, and Wheat Protein;
Folium Perillae [latin name] erillafrutescens (L.) Britt.: return lung, taste warp, induce sweat circulation of qi promoting and in, " book on Chinese herbal medicine converge with speech ": " Folium Perillae, cold expelling gas, lung heat clearing gas, alleviating distention in middle-JIAO gas, antiabortive gas, lower stagnation of QI, reduce phlegm gas, be control gas refreshing medicine also.". " medicineization justice ": " Folium Perillae is the thing of generation.Xin Wenneng falls apart, and gas Bao Nengtong, taste is thin to be given vent to.”
Fructus Citri Limoniae [latin name] Citruslimon: nature and flavor acid is sweet cool, attaches to the lung and stomach meridians, the merit of promoting the production of body fluid to quench thirst stomach function regulating; Fructus Citri Limoniae quintessence oil has calm gentle merit.
The present invention adopts the compositions of above-mentioned five kinds of compositions, resolving depression of regulating the flow of vital energy, tranquilizing by nourishing the heart, blood circulation promoting and blood stasis dispelling, and make gentle the relaxing of fur space between skin and muscles support, channels and collaterals running Shu Chi degree of having, anxiety is tired out to be dissolved.
Therefore, in one aspect of the invention, provide a kind of for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 25-30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15-20 volume %;
The Ganoderma quintessence oil of 15-25 volume %;
The Fructus Perillae quintessence oil of 15-20 volume %;
The Fructus Citri Limoniae quintessence oil of 15-18 volume %;
Wherein, in described compositions, each component sum is 100 volume %.
In one preferred embodiment, the invention provides a kind of for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 28-30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15-20 volume %;
The Ganoderma quintessence oil of 16-22 volume %;
The Fructus Perillae quintessence oil of 15-18 volume %;
The Fructus Citri Limoniae quintessence oil of 16-18 volume %.
In one preferred embodiment, the invention provides a kind of for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 20 volume %;
The Ganoderma quintessence oil of 16 volume %;
The Fructus Perillae quintessence oil of 18 volume %;
The Fructus Citri Limoniae quintessence oil of 18 volume %.
In one preferred embodiment, the invention provides a kind of for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 28 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15 volume %;
The Ganoderma quintessence oil of 20 volume %;
The Fructus Perillae quintessence oil of 20 volume %;
The Fructus Citri Limoniae quintessence oil of 17 volume %.
In one preferred embodiment, the invention provides a kind of for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 25 volume %;
The Semen Ziziphi Spinosae quintessence oil of 20 volume %;
The Ganoderma quintessence oil of 22 volume %;
The Fructus Perillae quintessence oil of 15 volume %;
The Fructus Citri Limoniae quintessence oil of 16 volume %.
In an optional embodiment, herbal composite of the present invention also comprises other compositions.In a concrete embodiment, herbal composite of the present invention comprises depressed liver-energy dispersing and QI regulating constituents, such as Flos Rosae Rugosae, Fructus Citri Sarcodactylis, Fructus Citri, thus realizes the stagnant QI and blood of depressed liver-energy dispersing and QI regulating, the unobstructed stasis of blood.In another optional embodiment, herbal composite of the present invention can comprise constituents of releiving of calming the nerves.In a concrete embodiment, compositions of the present invention can comprise Lignum Aquilariae Resinatum, warm the five internal organs, refreshing sedate of diving.In a concrete embodiment, compositions of the present invention can comprise lavandula angustifolia, releives tired, pacifies balance emotion.In a concrete embodiment, compositions of the present invention can comprise Flos Pelargonii, eliminates anxiety and tense, relaxes pressure, balance body and mind.
In another aspect of this invention, provide a kind of herbal composite releive emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate tired out in application, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 25-30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15-20 volume %;
The Ganoderma quintessence oil of 15-25 volume %;
The Fructus Perillae quintessence oil of 15-20 volume %;
The Fructus Citri Limoniae quintessence oil of 15-18 volume %;
Wherein, in described compositions, each component sum is 100 volume %.
In another aspect of this invention, provide a kind of cosmetics, this toiletry bag is containing acceptable excipient on herbal composite and cosmetics, and according to the entire volume of described herbal composite, described herbal composite comprises:
The sandalwood essential oil of 25-30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15-20 volume %;
The Ganoderma quintessence oil of 15-25 volume %;
The Fructus Perillae quintessence oil of 15-20 volume %;
The Fructus Citri Limoniae quintessence oil of 15-18 volume %;
Wherein, in described compositions, each component sum is 100 volume %.
In another aspect of this invention, provide a kind of for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises: 4.746% phellandrene, 1.472% pinene, 1.965% d-limonen, 7.879% left-handed limonene, 3.390% cineole, 8.842% linalool, 2.114% rose oxide, 1.922% phenethanol, 1.670% formic acid-2-benzene second fat, 2.759% Borneolum Syntheticum, 1.844% terpineol, 2.790% citronellol, 1.585% citral, 1.640% nerol, 1.954% geranyl acetate, the other alkene of 1.562% beta waves, 1.479% heptane, 1.989% tiglic acid 2-phenyl chlorocarbonate, 16.997% cis-santalol, 5.065% bergamot alcohol, 9.004% trans-santalol.
In a concrete embodiment, described cosmetics are skin preparations for extenal use.
In some embodiments, with the total weight of described skin preparations for extenal use, the consumption of described herbal composite is 0.001-20% (w/w), be preferably 0.001-10% (w/w), be more preferably 0.01-5% (w/w), most preferably be 0.01-2% (w/w).
Accompanying drawing explanation
The TIC X-Y scheme of embodiment 2 that Fig. 1 shows " Chinese Fragrant ".
The TIC graphics of embodiment 2 that Fig. 2 shows " Chinese Fragrant ".
The TIC figure of embodiment 2 that Fig. 3 shows " Chinese Fragrant ".
Detailed description of the invention
The invention describes and sandalwood essential oil, Semen Ziziphi Spinosae quintessence oil, Ganoderma quintessence oil, Fructus Perillae quintessence oil, Fructus Citri Limoniae quintessence oil are combined a kind of herbal composite obtained.Through related efficacy checking, effect that herbal composite of the present invention has emotion of releiving, loosens decompression, relieving mental strain and helping sleep, elimination are tired out.Therefore, herbal composite of the present invention can join in cosmetics as functional additive, reaches the effect of releive pressure and/or fatigue alleviating.
All do not relate to sandalwood essential oil of the present invention in document, Semen Ziziphi Spinosae quintessence oil, Ganoderma quintessence oil, Fructus Perillae quintessence oil, Fructus Citri Limoniae quintessence oil combine the herbal composite obtained, also the not mentioned functional additive that it can be used as adds in cosmetics.Therefore, the present invention proposes first and combines with sandalwood essential oil, Semen Ziziphi Spinosae quintessence oil, Ganoderma quintessence oil, Fructus Perillae quintessence oil, Fructus Citri Limoniae quintessence oil the herbal composite obtained, this herbal composite has unexpected technique effect of the present invention, emotion of namely can releiving and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate tired out.
In cosmetic applications, herbal composite of the present invention can be applied to various forms.Such as, herbal composite of the present invention can be applied to any dosage forms being applied to human body skin such as facial milk cleanser, astringent, emulsion, cream frost, gel, facial film, bath gel.
The present invention is set forth further below in conjunction with specific embodiment.But, should be understood that these embodiments only do not form limitation of the scope of the invention for illustration of the present invention.The test method of unreceipted actual conditions in the following example, usually conveniently condition, or according to the condition that manufacturer advises.Except as otherwise noted, all percentage ratio and number are by weight.
The raw material adopted in embodiment 1-3 is commercially available sandalwood essential oil, commercially available Semen Ziziphi Spinosae quintessence oil, commercially available Ganoderma quintessence oil, commercially available Fructus Perillae quintessence oil, commercially available Fructus Citri Limoniae quintessence oil.Further, the ratio in comparative example and embodiment 1-3 is percent by volume.
The sandalwood essential oil used in the present invention, Semen Ziziphi Spinosae quintessence oil, Ganoderma quintessence oil, Fructus Perillae quintessence oil, Fructus Citri Limoniae quintessence oil are all purchased from Man (Shanghai) essence and flavoring agent company limited.
Comparative example: the screening of herbal composite
Theoretical prescription: according to " monoblock type is taken good care of " principles of formulating prescriptions of innovative Chinese Fragrant, comprehensive embodiment effect and fragrance, first select " monarch " composition with relaxation effect of releiving, and consider the stereovision of fragrance, obtain following optional prescription scheme:
Prescription 1: by Lignum Santali Albi: Semen Ziziphi Spinosae: the volume ratio of Ganoderma=30:20:16, under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instills in empty Ethereal oil bottle successively, after covering tightly bottle stopper, rocks evenly, for subsequent use.
Prescription 2: by Lignum Santali Albi: Semen Ziziphi Spinosae: Ganoderma: the volume ratio of Folium Perillae=30:20:16:18, under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instills in empty Ethereal oil bottle successively, after covering tightly bottle stopper, rocks evenly, for subsequent use.
Prescription 3: by Lignum Santali Albi: Semen Ziziphi Spinosae: Ganoderma: the volume ratio of Fructus Citri Limoniae=30:20:16:18, under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instills in empty Ethereal oil bottle successively, after covering tightly bottle stopper, rocks evenly, for subsequent use.
Prescription 4: by Lignum Santali Albi: Semen Ziziphi Spinosae: Ganoderma: Folium Perillae: the volume ratio of Fructus Citri Limoniae=30:20:16:18:18, under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instills in empty Ethereal oil bottle successively, after covering tightly bottle stopper, rocks evenly, for subsequent use.
Above-mentioned prescription is carried out Wen Xiang test, tests the hobby sense to fragrance and the instant impression loosened of releiving.Method is: choose 15 routine experimenters (25-50 year, healthy without quintessence oil or champignon allergies), inform first 12 hours of test can not smoking, take in maror and drink drinks, beverage containing pungents such as caffeine.At emotion tranquility, in fixing quiet airspace, open the quintessence oil bottle cap of 4 prescriptions successively, carry out smelling news, judge whether the instant hobby sense to fragrance and Wen Xianghou have instant refreshing oneself and rouse oneself impression.Add up each one favorite fragrance prescription and have most to releive and loosen the prescription of instant impression, result is as following table.
| The sense of fragrance hobby | Releive and loosen instant impression | |
| Prescription 1 | 1 | 1 |
| Prescription 2 | 2 | 3 |
| Prescription 3 | 5 | 2 |
| Prescription 4 | 7 | 9 |
In upper table, mark higher, represent better to the hobby of fragrance, releiving, it is also better to loosen instant impression.Visible, no matter prescription 4 is the preference degree of perfumery, and the instant impression loosened of releiving all obviously is better than its excess-three prescription, therefore, selects prescription 4 to enter next step test.
Embodiment 1: the preparation of herbal composite
Get sandalwood essential oil 30%, Semen Ziziphi Spinosae quintessence oil 20%, Ganoderma quintessence oil 16%, Fructus Perillae quintessence oil 18%, Fructus Citri Limoniae quintessence oil 18%, under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instill successively in empty Ethereal oil bottle, after covering tightly bottle stopper, rock evenly, for subsequent use.
Embodiment 2: the preparation of herbal composite
Get sandalwood essential oil 28%, Semen Ziziphi Spinosae quintessence oil 15%, Ganoderma quintessence oil 20%, Fructus Perillae quintessence oil 20%, Fructus Citri Limoniae quintessence oil 17%; Under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instills in empty Ethereal oil bottle successively, after covering tightly bottle stopper, rocks evenly, for subsequent use.
Embodiment 3: the preparation of herbal composite
Get sandalwood essential oil 25%, Semen Ziziphi Spinosae quintessence oil 22%, Ganoderma quintessence oil 22%, Fructus Perillae quintessence oil 15%, Fructus Citri Limoniae quintessence oil 16%, under room temperature ventilation state, what calculate above-mentioned required quintessence oil drips number, accurately instill successively in empty Ethereal oil bottle, after covering tightly bottle stopper, rock evenly, for subsequent use.
Embodiment 4: efficacy detection
Have chosen 120 student enrollment, wherein, " Chinese Fragrant " embodiment 1 group of 30 people, " Chinese Fragrant " embodiment 2 group of 30 people, " Chinese Fragrant " embodiment 3 group of 30 people, blank group 30 people.University students have passed through strict choice before entering group, and choice standard comprises:
(1) more than one full year of life at age 18;
(2) before entering group, health check-up is healthy;
(3) enter to organize in first 1 month without great Psychomotor test Battrey event;
(4) allergies are used without any incense, quintessence oil;
(5) accept voluntarily tested, can coordinate and accept coherence check and sign Informed Consent Form.
Before experiment, tester be apprised of first 12 hours of test can not smoking, take in maror and drink drinks, beverage containing pungents such as caffeine.To test in one week not strenuous exercise, stay up late, be engaged in the activity excessive to Psychological stimulation.
Hear the 19:00-20:00 of fragrant experimental selection every day as the news fragrant time, hearing the fragrant cycle is 7 days.The collection of experiment saliva sample is divided into twice, is captured in for the first time before hearing perfume (or spice) for the first time and carries out, and second time is carried out after being captured in last news perfume (or spice), collection saliva sample is carried out SIgA content in saliva and salivary cortisol mensuration.
" Chinese Fragrant " is tested the interior space that group name university students is organized into fixing quiet two isolation, around without the crowd of smoking, spraying perfume, do not interfere with each other between experimental group.Wen Xiang starts previous hour, researcher use electronic atomizing machine fill whole space by quintessence oil, and in experimentation sustained release fragrance.University students Wen Xiangshi is engaged in reading, closes the eyes for rest or other activities of releiving.Blank group focuses on another equivalent interior space, adopts the tasteless diffusion of pure water in contrast.
And afterwards Scale and questionnaire is carried out to each group of crowd on pretreatment.Five kinds of international and domestic general psychological scalies are used to assess " Chinese Fragrant " for the able-bodied effect of university students.The scale that this research adopts comprises SDS-self rating depressive scale, CES-D-Liu Tiao center depression scale, Pittsburgh Sleep Quality Index questionnaire.
Experimental result
(1) SIgA content in saliva
Experiment collection is divided into twice, carries out before being captured in first time news perfume (or spice) for the first time, and second time is carried out after being captured in last news perfume (or spice).Gather first 10 minutes, experimental subject clear water is gargled.Use saliva cotton sliver collection tube to gather saliva, the top of collection tube be one can take out below be with foraminate tubule, have one inside tubule in order to infiltrate the cotton sliver of saliva, after centrifugal, saliva flows to the bottom of saliva cotton sliver collection tube by aperture.Cotton sliver is placed in Sublingual about 2 minutes by experimental subject, put back to after cotton sliver is by saliva complete wetting in the tubule of collection tube, 3000 rpms of (rpm) speed are adopted to carry out centrifugal 15min, saliva after centrifugal flows to the bottom of saliva cotton sliver collection tube by aperture, collect saliva and be about 6ml (at least 4ml), be stored in saliva cotton sliver collection tube, and cold preservation immediately.By frozen for the refrigerator-freezer that centrifugal complete saliva cotton sliver collection tube sends to-20 DEG C in 30min, detected in 15 days.In the ordinary course of things, concentration of cortisol in blood is far away higher than salivary cortisol concentration, therefore blood contamination can have a strong impact on the measurement result of salivary cortisol, so after gathering, experimenter with the naked eye should check that saliva cotton sliver is with or without by intraoral blood contamination one by one, as gingival hemorrhage etc., if saliva cotton sliver is by blood contamination, rejects this object of study for not meeting test requirements document person, no longer continue to participate in the experiment, filled by candidate object of study.Coagulase linked immunosorbent assay (Enzymelinkedimmunosorbentassay, ELISA) test kit is adopted to detect SIgA content.
Following table 1 shows Wen Xiangqian (the 0th day) and Wen Xianghou (the 7th day) experimental subject SIgA content in saliva content (μ g/ml) change.
Table 1
* p < 0.05, represents significant difference; * p < 0.01., represents pole significant difference.
SIgA content in saliva level can reflect the state of human body non-specific immunity more delicately.The crowd SIgA level also corresponding decline of immunologic hypofunction.Experiment shows: although each group of " Chinese Fragrant " embodiment does not present significant difference in the contrast hearing fragrant front and back SIgA content, but as can be seen from the above table, blank group was through 7 day time, in saliva, SIgA content has downward trend, but in each group of " Chinese Fragrant " embodiment in experimental subject saliva SIgA content in rising trend.Experiment shows, each group of enhancing for body immunity, resistance of " Chinese Fragrant " embodiment also has certain effect.
(2) salivary cortisol
Experiment collection is divided into twice, carries out before being captured in first time news perfume (or spice) for the first time, and second time is carried out after being captured in last news perfume (or spice).Gather first 10 minutes, experimental subject clear water is gargled.Use saliva cotton sliver collection tube to gather saliva, the top of collection tube be one can take out below be with foraminate tubule, have one inside tubule in order to infiltrate the cotton sliver of saliva, after centrifugal, saliva flows to the bottom of saliva cotton sliver collection tube by aperture.Cotton sliver is placed in Sublingual about 2 minutes by experimental subject, put back to after cotton sliver is by saliva complete wetting in the tubule of collection tube, 3000 rpms of (rpm) speed are adopted to carry out centrifugal 15min, saliva after centrifugal flows to the bottom of saliva cotton sliver collection tube by aperture, collect saliva and be about 6ml (at least 4ml), be stored in saliva cotton sliver collection tube, and cold preservation immediately.By frozen for the refrigerator-freezer that centrifugal complete saliva cotton sliver collection tube sends to-20 DEG C in 30min, detected in 15 days.In the ordinary course of things, concentration of cortisol in blood is far away higher than salivary cortisol concentration, therefore blood contamination can have a strong impact on the measurement result of salivary cortisol, so after gathering, experimenter with the naked eye should check that saliva cotton sliver is with or without by intraoral blood contamination one by one, as gingival hemorrhage etc., if saliva cotton sliver is by blood contamination, rejects this object of study for not meeting test requirements document person, no longer continue to participate in the experiment, filled by candidate object of study.Coagulase linked immunosorbent assay (Enzymelinkedimmunosorbentassay, ELISA) test kit is adopted to detect salivary cortisol content.
Following table 2 shows Wen Xiangqian (the 0th day) and the change of Wen Xianghou (the 7th day) experimental subject salivary cortisol concentration (pmol/ml).
Table 2
* p < 0.05, represents significant difference; * p < 0.01., represents pole significant difference.
Hydrocortisone can maintain the normal physiological function of pressure state lower body; If lack hydrocortisone, health then cannot make effecting reaction to pressure.Under being in pressure state for a long time, cortisol levels can be made higher, cannot normal regulating.And test shows, blank group is after 7 days, and body inner cortex determining alcohol has downward trend, but embodiment 1-3 group sample presents obvious ascendant trend, present significant change with own control, show that each group of " Chinese Fragrant " embodiment can promote the rising of Human Cortex's determining alcohol.
(3) scale evaluation and test:
This research have employed self rating depressive scale, the effect of " Chinese Fragrant " embodiment group for human body unhealthy emotion (spirit) state assessed by Liu Tiao center depression scale, Pittsburgh Sleep scale.
Self rating depressive scale contains 20 projects, is divided into 4 grades of independently scorings.Be characterized in easy to use, and the subjective feeling of depressive patient can be reflected quite intuitively.
As shown in table 3 below, experimental subject is being smelt before and after news " Chinese Fragrant " embodiment 1, depressed index score declines nearly 9 points, experimental subject is being smelt before and after news " Chinese Fragrant " embodiment 2, depressed index score declines nearly 5 points, experimental subject is being smelt before and after news " Chinese Fragrant " embodiment 3, depressed index score declines more than 8 points, and blank group one week retarded depression index score rises 3 points and has a surplus, and " Chinese Fragrant " each embodiment group all presents pole significant difference in own control and blank two groups contrast.Result shows, each group of control for human body depressive emotion of " Chinese Fragrant " embodiment and improvement have obvious effect.
Table 3: Wen Xiangqian and Wen Xiang retarded depression Self-assessment Scale (SDS) (average mark) result
* p < 0.05, represents significant difference; * p < 0.01., represents pole significant difference.
Liu Tiao center depression scale is that US National mental health academy was in establishment in 1977, also examination general population being carried out to depressive symptom is widely used in the world at present, be not limited to design beginning for Adult Groups, also can be used for teenager and elderly population.It measures the depressive symptoms such as content comprises valueless sense, appetite declines, depressed, desperate, sleep disturbances, attention are poor.
And use in the assessment of Liu Tiao center depression scale, each group of " Chinese Fragrant " embodiment all presents significant difference in contrast: the depressed score of embodiment 1 group have dropped more than 2 points, the depressed score of embodiment 2 groups have dropped nearly 3 points, the depressed score of embodiment 3 groups have dropped more than 1 point, and blank group rises more than 1 point, again demonstrate the Pasitive Regulation Effect of Genseng of " Chinese Fragrant " A for human body depressive emotion, as shown in table 4 below:
Table 4: Wen Xiangqian and Wen Xiang Hou Liutiao center depression scale (average mark) result
* p < 0.05, represents significant difference; * p < 0.01., represents pole significant difference.
Pittsburgh Sleep scale can from the sleep quality of the aspect Comprehensive evaluation experimental objects such as time for falling asleep/sleep duration/Sleep efficiency.Scale by 7 parts totally 19 problems form, total score is 0 ~ 21 point, (0 point of representative does not have sleeping problems, the sleeping problems that 21 points of representatives are very serious), this test mainly uses the total score of scale, carrys out globality reflection " Chinese Fragrant " to the impact of sleep quality.
As shown in table 5 below, " Chinese Fragrant " embodiment 2 group objects sleep index all presents pole significant difference in own control and blank, after each group of embodiment smells news quintessence oil, score all have dropped about 2 points, and blank group rises about 1 point, the above results is consistent with effect of essential oil relieving mental strain and helping sleep.
Table 5: Pittsburgh Sleep index scale (average mark) result after Wen Xiangqian and Wen Xiang
* p < 0.05, represents significant difference; * p < 0.01, represents pole significant difference.
Embodiment 5:3GC-MS gas chromatogram composition test
Through saliva physical signs and psychological scale index determining and analysis, in order to understand effect principle of this embodiment compound essential Oil better, carry out GC-MS detection again.
Instrument main working parameters: LECO company of U.S. comprehensive two dimensional gas chromatography-flight time mass spectrum 7890GC/Pegasus4DGCxGC-TOFMS; First dimension chromatographic column: DB-5MS (30m × 0.25mm × 0.25 μm); Injector temperature: 270 DEG C; Sample size: 1.0 μ L; Column temperature: 60 DEG C keep 3.0min, rise to 280 DEG C with 4.0 DEG C/min, keep 2.5min; Nebulizer gas pressure or flow: 1.0mL/min; Split ratio: without shunting; Helium (99.999%); Second dimension chromatographic column: DB-17MS (2m × 0.10mm × 0.10 μm); The modem cycle: 4.0s; Column temperature: all the time higher than one-dimension temperature 10 DEG C; Modulation /demodulation actuator temperature: all the time higher than two-dimension temperature 15 DEG C; Interface temperature: 270 DEG C; Ion source temperature: 220 DEG C; Ionization mode: electron bombardment ionization source; Electron multiplier: 1800V; Scan mode: 30-550amu; NIST2011 composes storehouse.By detecting the TIC figure delineating the TIC X-Y scheme of the GC × GC-TOFMS of two kinds of quintessence oils, the TIC graphics of GC × GC-TOFMS and GC × GC-TOFMS.Fig. 1-3 shows the TIC X-Y scheme of " Chinese Fragrant " embodiment 2, TIC graphics and TIC figure.
" Chinese Fragrant " embodiment 2 survey composition 915, wherein similarity is greater than 600, and probability is greater than 4000, amounts to 430, and drawn component analysis through further screening (component content is greater than 1%), result is as shown in table 6.
Table 6: composite precision main body of oil in embodiment 2
As can be seen from composition, sesquiterpene alcohols, the monoterpene compounds of " Chinese Fragrant " embodiment 2 containing higher proportion, the effect that having releives loosens, people can be made to loosen, alcohols, aldehydes, esters, ethers all have certain content simultaneously, in raising immunity, there is certain effect the aspects such as bactericidal antiphlogistic.Comparatively identical with the target effect of " Chinese Fragrant " embodiment 2 relieving mental strain and helping sleep.
Compound essential Oil the present invention obtained is used for domestic chemical products, can be used as efficacy active component or use as essence and flavoring agent, fragrant taste is sweet, softly joyful, application form can be any dosage forms that can be applied to human body skin such as facial milk cleanser, bath oil, emulsion, cream frost, shampoo, as follows.
Embodiment 6: the preparation (comprising day cream and late frost) of facial cream
Embodiment 7: the preparation of emulsion
Embodiment 8: the preparation of facial film
Embodiment 9: the preparation of bath gel
Claims (9)
1., for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate a herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises:
The sandalwood essential oil of 25-30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15-20 volume %;
The Ganoderma quintessence oil of 15-25 volume %;
The Fructus Perillae quintessence oil of 15-20 volume %;
The Fructus Citri Limoniae quintessence oil of 15-18 volume %;
Wherein, in described compositions, each component sum is 100 volume %.
2. herbal composite as claimed in claim 1, it is characterized in that, described compositions comprises:
The sandalwood essential oil of 28-30 volume %;
The Semen Ziziphi Spinosae quintessence oil of 15-20 volume %;
The Ganoderma quintessence oil of 16-22 volume %;
The Fructus Perillae quintessence oil of 15-18 volume %;
The Fructus Citri Limoniae quintessence oil of 16-18 volume %.
3. one kind for releiving emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate herbal composite tired out, according to the entire volume of described herbal composite, described compositions comprises: 4.746% phellandrene, 1.472% pinene, 1.965% d-limonen, 7.879% left-handed limonene, 3.390% cineole, 8.842% linalool, 2.114% rose oxide, 1.922% phenethanol, 1.670% formic acid-2-benzene second fat, 2.759% Borneolum Syntheticum, 1.844% terpineol, 2.790% citronellol, 1.585% citral, 1.640% nerol, 1.954% geranyl acetate, the other alkene of 1.562% beta waves, 1.479% heptane, 1.989% tiglic acid 2-phenyl chlorocarbonate, 16.997% cis-santalol, 5.065% bergamot alcohol, 9.004% trans-santalol.
4. the herbal composite as described in any one of claim 1-3, is characterized in that, described compositions also comprises depressed liver-energy dispersing and QI regulating constituents and/or constituents of releiving of calming the nerves.
5. herbal composite as claimed in claim 4, it is characterized in that, described depressed liver-energy dispersing and QI regulating constituents is selected from: Flos Rosae Rugosae, Fructus Citri Sarcodactylis, Fructus Citri.
6. herbal composite as claimed in claim 4, is characterized in that, described in calm the nerves constituents of releiving be selected from: Lignum Aquilariae Resinatum, lavandula angustifolia, Flos Pelargonii.
7. the herbal composite according to any one of claim 1-6 releive emotion and/or loosen decompression and/or relieving mental strain and helping sleep and/or eliminate tired out in application.
8. one kind comprises the skin preparations for extenal use of the herbal composite according to any one of claim 1-6.
9. skin preparations for extenal use as claimed in claim 8, it is characterized in that, with the total weight of described skin preparations for extenal use, the consumption of described herbal composite is 0.001-20% (w/w), be preferably 0.001-10% (w/w), be more preferably 0.01-5% (w/w).
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| CN111166817A (en) * | 2020-02-14 | 2020-05-19 | 江西中医药大学 | Compound essential oil for improving sleep, tranquilizing mind and relieving depression and composition thereof |
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