CN105288421B - A kind of inducing resuscitation that clears away heart-fire rouses oneself mood, the herbal composite that decompression is recovered from fatigue - Google Patents
A kind of inducing resuscitation that clears away heart-fire rouses oneself mood, the herbal composite that decompression is recovered from fatigue Download PDFInfo
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Abstract
The invention discloses inducing resuscitation and/or mood and/or the herbal composite that recovers from fatigue of decompression is rouse oneself for clearing away heart-fire, according to the total volume meter of the herbal composite, the composition includes: the fructus alpiniae oxyphyllae essential oil of 15-30 volume %；The grapefruit essential oil of 20-25 volume %；The cardamom essential oil of 15-30 volume %；The fructus lycii essential oil of 10-20 volume %；The Peppermint essential oil of 10-20 volume %, wherein the sum of each component is 100 volume % in the composition.The invention further relates to application of the herbal composite in cosmetics.
Description
Technical field
The present invention relates to field of natural medicinal chemistry and cosmetic field, and in particular to one kind for clear away heart-fire inducing resuscitation, rouse oneself
The herbal composite that mood, decompression are recovered from fatigue, the preparation method of the herbal composite and application.
Background technique
With the development and the accelerating rhythm of life of society, " tired " common fault for becoming society.The Center for Disease Control
(CDC) it is referred to as chronic fatigue syndrome.Fatigue belongs to Social Medicine scope, ought to cause include medical field various circles of society
Extensive reproduction, fatigue is formally classified as one kind of occupational disease by Japan.There are about 35% or more in World Health Organization's investigation whole world
People is in a state of fatigue.Foreign data is shown, in general population, continues the phenomenon of fatigue with the presence of 5%~20% people；It is primary
Fatigue is one of most common symptom in medical treatment, has 5%~20% patient main suit for fatigue, separately there is 5%~20% patient
Think that fatigue is their important simultaneous phenomenons.So fatigue may be a kind of protectiveness irritability physiological reaction, also may be
Internal organs organ loses the pathologic reaction of non-equilibrium stable state, it alerts body and needs to handle, needs to adjust.
A subjective feeling symptom of the fatigue as body is that body physical strength or energy weaken or loses a kind of complicated
The embodiment of physiology, psychology and pathological phenomenon.Therefore, fatigue can see Healthy People, can also be used as a disease, see many
The Other diseases of corporality, psychological mental disease and human body.Fatigue performance include: it is tired out, limb aching pain is uncomfortable, sleep is disorderly
Unrest, emotional maladjustment (amnesia, emotional, fidgety, depressed, distraction, thinking be not quick) etc..Not only in this, fatigue can also
So that work and various aspects ability is declined > 30%, and will appear the inferior health performance even psychosomatic in terms of many bodies and minds, such as
Bronchitis, asthma, nonspecific colonitis, heart disease, palpitaition, nettle rash, essential hypertension, peptic ulcer, stomachache,
Insomnia etc., seriously affects health.
Chinese medicine thinks that fatigue has various performances, such as: confused tired (insobriety), sleepy (a certain position of human body is uncomfortable
Sense), lazy tired (being reluctant activity), mind it is tired it is (listless), be tired of tired (unhappy irritable), soft tired (body is weak uncomfortable), burnout (lazy nothing
Mind), tired (sleepy and tired), dusk tired (dizzy lazy move), mind tired (insobriety is easily forgotten), idle (powerlessly keeping forging ahead), (few power out of strength
Gas), power is insufficient (unable to do what one wishes), neck sour (neck acid is heavy), shoulder sour (shoulder acid is heavy) etc..Wherein, it and is allocated as partially empty and inclined
It is two kinds real.Since tension pressure causes liver and gallbladder fire to be contained, stagnation of liver qi, and worry impairing spleen person are relatively real, and performance is with unhappy irritable easy
Anger, limb aching pain, based on vexed insomnia dreaminess.Another kind, ferritic yang-energy is deficient or fatigue is pondered over consumption impairment of yin blood person and is partial to
Void shows themselves in that heavy murky drowsiness, depressed, limbs or weak uncomfortable, dizzy lazy move, powerless keep forging ahead, is unable to do what one wishes.
The cause of disease and pathogenesis of fatigue are unknown, but abnormal, psychological and social factor the exception of immune function is to cause
The basic reason that fatigue occurs.Reinforce the immune function of body, improve psychological quality with the ability to bear for adapting to society to be to pass
Important.For fatigue, for doctor trained in Western medicine because of its objective basis without obvious pathological change, effective prevention and treatment measure is limited, and
" preventiveing treatment of disease " theory of Chinese medicine is but perfectly in harmony with it, and Chinese medicine emphasizes diagnosis and treatment and comprehensive measure, and control efficiency pole has
Advantage.
Studies have shown that being aromatotherapy for one of mode of tired effective prevention.According to a domestic virtue in 2011
Fragrant therapy market real example survey report is shown: aromatotherapy has as a kind of pure natural, Small side effects and loosens body and mind, alleviates
The method of pressure effect has the very big market demand.
Aromatotherapy is long-standing.Its definition is one and reaches health care using plants essential oil (essentialoil)
With the art and science of beauty.It is the elegant fragrance come out of fragrance ingredient that volatilized by fragrance, sucks people through olfactory organ
In vivo, it or is directly contacted with skin surface and generates apparent psychology, physiological reaction, to reach health care, cure the disease, the mesh of beauty
's.For thousands of years, Chinese medicine utilizes the fragrance ingredient of natural aromatic plant, by number of ways such as massage, shower, outer painting, Wen Xiang,
It gets rid of illness and health-care effect to human body generation.Virtue is treated in China, and accurate saying is that " fragrant medication " is more definite.With west fragrance
The difference of therapy is that fragrant medication followed is the theoretical system of traditional Chinese medicine, and dosage form and application method are more various, Bu Shaofang
Incense drug enters decoction application mostly, therefore fails to form " essential oil " such a concentrate very much and the transmitting carrier of characteristic.But China
The treatment of formula virtue is compared with Western-style, is had theoretical system, specific ingredient, application mode, the difference of prescription theory, is more suitable in fact
" Chinese style " that compatriots use, " Chinese Fragrant ".
Therefore, the present invention develops the inducing resuscitation that clears away heart-fire, rouses oneself mood, decompression for the performance of above-mentioned " inclined deficiency " tired crowd
The herbal composite to recover from fatigue.It is intended under the theoretical direction of " preventiveing treatment of disease ", side effect and the effect for evading pharmaceutical intervention are uncertain
Property, the combination of Chinese style incense drug is selected, by the apparent effect of experimental verification, mechanism is illustrated, and can have product form abundant, has
High application and popularization value.
Summary of the invention
It is well known in the art that pressure heavy burden is with the passing of time, or and ferritic this void, murky drowsiness, the depressed, limb of appearance
Body is heavy or weak uncomfortable, dizzy lazy move, it is powerless keep forging ahead, be unable to do what one wishes, continued downturn, influence good ability to work and emotion
It playing, working efficiency reduces, and Chinese medicine thinks, this is because ferritic yang-energy is deficient or fatigue ponders over consumption impairment of yin blood, painstaking effort are impaired,
Brain network lose in honor support, and or the deficiency of vital energy life it is wet, blind clear key so that mind dystrophy, coma is out of strength, and limbs are deep, meridian qi and blood fortune
Row is powerless, above-mentioned discomfort occurs.
It is recognized based on above-mentioned theory, the present invention is prepared for a kind of new using fructus alpiniae oxyphyllae, grape fruit, cardamom, fructus lycii, peppermint
Herbal composite.Specifically, the pungent perfume of intelligence development is warm in formula of the invention, QI invigorating Wen Yang enters brain network, and power-assisted vigour is living
Power is monarch drug in a prescription；The unique pure and fresh gas of grape fruit, reaches the function of the anti-sorrow of inducing resuscitation, and prevent the qi and blood that is jammed of help, is ministerial drug；Cardamom is warm
Middle coke, row lung qi；It closes fructus lycii tool and moistens the property for supporting reconciliation, avoid the excessively pungent fragrant gas consumption in full side, be altogether adjutant；Peppermint is pungent cool to be good at solving
Strongly fragrant to have one's ideas straightened out, pure and fresh inducing resuscitation at once is to make medicine.
Fructus alpiniae oxyphyllae [latin name] Fructus Alpinae Oxyphyllae, property and flavor of peppery and warm, returns spleen kidney channel, effect temperature spleen are warm
Kidney；
Grape fruit [latin name] Citrus paradisi Macf: grapefruit essential oil characteristic: blood clean, excitation lymph follow
Ring and digestive system, nourishing；And central nervous system can be balanced, inhibit dejected, pressure of releiving；
Amomum cardamomum [latin name] Amomum kravanh Pierre ex Gagnep: property and flavor of peppery and warm, return lung taste warp, function
Effect: dampness elimination promoting the circulation of qi, middle benefit gas；
Fructus lycii [latin name] Lycium barbarum L: sweet in flavor and neutral in nature returns liver kidney channel, effect: nourishing liver and kidney, strengthening the essence is bright
Mesh calms the nerves, is promoting production of body fluid and nourishing the lung, pleasing profit skin, " haigoushen ": " energy help essence various symptims and signs of deficiency, easy color bleach, and improving eyesight and quiet nerves makes us long
Longevity "；
Peppermint [latin name] Mentha haplocalyx Briq.: it is pungent in flavor and cool in property, return liver lung channel, effect: head clearing,
Liver depression is discongested, " book on Chinese herbal medicine is newly organized ": " not special kind solution ailment said due to cold or exposure, outstanding kind solution are melancholy "；Peppermint essential oil can chill out shakiness, and spirit is tired
It is tired.
The present invention uses the composition of above-mentioned five kinds of ingredients, and inducing resuscitation is had one's ideas straightened out, and QI invigorating Wen Yang inspires enthusiasm, parallel brain network, enables
Mind is clever clearly, and body is felt well clean thorough, and channels and collaterals running flushes.
Therefore, in one aspect of the invention, provide and a kind of inducing resuscitation and/or rouse oneself mood and/or decompression solution for clearing away heart-fire
Weary herbal composite, according to the total volume meter of the herbal composite, the composition includes:
The fructus alpiniae oxyphyllae essential oil of 15-30 volume %；
The grapefruit essential oil of 20-25 volume %；
The cardamom essential oil of 15-30 volume %；
The fructus lycii essential oil of 10-20 volume %；
The Peppermint essential oil of 10-20 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
In one preferred embodiment, it provides and a kind of inducing resuscitation and/or rouses oneself mood and/or decompression solution for clearing away heart-fire
Weary herbal composite, according to the total volume meter of the herbal composite, the composition includes:
The fructus alpiniae oxyphyllae essential oil of 17-28 volume %；
The grapefruit essential oil of 20-23 volume %；
The cardamom essential oil of 18-20 volume %；
The fructus lycii essential oil of 14-20 volume %；
The Peppermint essential oil of 14-18 volume %.
In one preferred embodiment, it provides and a kind of inducing resuscitation and/or rouses oneself mood and/or decompression solution for clearing away heart-fire
Weary herbal composite, according to the total volume meter of the herbal composite, the composition includes:
The fructus alpiniae oxyphyllae essential oil of 25 volume %；
The grapefruit essential oil of 22 volume %；
The cardamom essential oil of 20 volume %；
The fructus lycii essential oil of 18 volume %；
The Peppermint essential oil of 15 volume %.
In one preferred embodiment, it provides and a kind of inducing resuscitation and/or rouses oneself mood and/or decompression solution for clearing away heart-fire
Weary herbal composite, according to the total volume meter of the herbal composite, the composition includes:
The fructus alpiniae oxyphyllae essential oil of 28 volume %；
The grapefruit essential oil of 20 volume %；
The cardamom essential oil of 18 volume %；
The fructus lycii essential oil of 20 volume %；
The Peppermint essential oil of 14 volume %.
In one preferred embodiment, it provides and a kind of inducing resuscitation and/or rouses oneself mood and/or decompression solution for clearing away heart-fire
Weary herbal composite, according to the total volume meter of the herbal composite, the composition includes:
The fructus alpiniae oxyphyllae essential oil of 17 volume %；
The grapefruit essential oil of 23 volume %；
The cardamom essential oil of 28 volume %；
The fructus lycii essential oil of 14 volume %；
The Peppermint essential oil of 18 volume %.
In another aspect of this invention, it provides and a kind of inducing resuscitation and/or to rouse oneself mood and/or decompression is recovered from fatigue for clearing away heart-fire
Herbal composite, the composition include 7.491% amphene of relative amount, 2.964% laurene, 5.586% firpene,
1.769% p-cymene, 9.980% limonene, 1.205% terpinene-4-alcohol, 5.033% terpinol, 3.436% carveol,
4.902% linalool, 6.688% carvol, 18.232% dihydromyrcenol, 1.961% geranyl acetate, 2.642% stone
Bamboo olefinic oxide.
In an optional embodiment, herbal composite of the invention also includes other ingredients.It is specific at one
Embodiment in, herbal composite of the invention includes QI invigorating temperature sun constituents, such as ginseng, cortex cinnamomi, Wen Yang enter brain network,
Power-assisted vigour vigor.In a specific embodiment, herbal composite of the invention may include fragrant qi-regulating constituents,
Such as jasmine, jasmine fragrance please heart spleen.In a specific embodiment, herbal composite of the invention may include fragrance
Qi-regulating constituents, such as rosemary, clear-minded head enhance memory.In one specific embodiment, Chinese herbal medicine of the invention
Composition may include fragrant qi-regulating constituents, such as bergamot, improve tension pressure, anti-depression.One specific embodiment
In, herbal composite of the invention may include fragrant qi-regulating constituents, such as lemon, and pure and fresh inducing resuscitation, order is pondered over clear.One
In specific embodiment, herbal composite of the invention may include the wet constituents of pungent sweetening treatment, such as wrinkled giant hyssop, elscholtiza, Xin Xiang
Delicate fragrance, benefaction fleshy exterior open lung qi, and sharp water-wet in capable of entering.In one specific embodiment, Chinese herbal medicine combination of the invention
Object may include the wet constituents of pungent sweetening treatment, such as ginger, pungent strong inducing resuscitation of having one's ideas straightened out, and enhance the power of dampness elimination inducing diaphoresis.
In another aspect of this invention, provide a kind of herbal composite clear away heart-fire inducing resuscitation and/or rouse oneself mood and/or
The application in recovering from fatigue is depressurized, according to the total volume meter of the herbal composite, the composition includes:
The fructus alpiniae oxyphyllae essential oil of 15-30 volume %；
The grapefruit essential oil of 20-25 volume %；
The cardamom essential oil of 15-30 volume %；
The fructus lycii essential oil of 10-20 volume %；
The Peppermint essential oil of 10-20 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
In another aspect of this invention, a kind of cosmetics are provided, which contains herbal composite and makeup
Acceptable excipient on product, according to the total volume meter of the herbal composite, the herbal composite includes:
The fructus alpiniae oxyphyllae essential oil of 15-30 volume %；
The grapefruit essential oil of 20-25 volume %；
The cardamom essential oil of 15-30 volume %；
The fructus lycii essential oil of 10-20 volume %；
The Peppermint essential oil of 10-20 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
In a specific embodiment, the cosmetics are skin preparations for extenal use.
In some embodiments, with the total weight of the skin preparations for extenal use, the dosage of the herbal composite is
0.001-20% (w/w), preferably 0.001-10% (w/w), more preferably 0.01-5% (w/w), most preferably 0.01-2%
(w/w)。
Detailed description of the invention
Fig. 1 shows the TIC X-Y scheme of the GC × GC-TOFMS of " Chinese Fragrant " embodiment 1.
Fig. 2 shows the TIC three-dimensional figure of the GC × GC-TOFMS of " Chinese Fragrant " embodiment 1.
Fig. 3 shows the TIC figure of the GC × GC-TOFMS of " Chinese Fragrant " embodiment 1.
Specific embodiment
The present invention, which describes, combines fructus alpiniae oxyphyllae essential oil, grapefruit essential oil, cardamom essential oil, fructus lycii essential oil, Peppermint essential oil
A kind of herbal composite arrived.It is verified through related efficacy, herbal composite of the invention has the inducing resuscitation that clears away heart-fire, rouses oneself feelings
The effect of thread, decompression are recovered from fatigue.Therefore, herbal composite of the invention can be used as functional additive and be added in cosmetics,
Have the function that clear away heart-fire inducing resuscitation, rouse oneself mood, decompression is recovered from fatigue.
Fructus alpiniae oxyphyllae essential oil of the present invention, grapefruit essential oil, cardamom essential oil, fructus lycii essential oil, peppermint are not directed in document
The herbal composite that essential oil combines is not referred to yet and being added in cosmetics as functional additive.Therefore, of the invention
It has been put forward for the first time the Chinese herbal medicine combined with fructus alpiniae oxyphyllae essential oil, grapefruit essential oil, cardamom essential oil, fructus lycii essential oil, Peppermint essential oil
Composition, the herbal composite have unexpected technical effect of the present invention, and the inducing resuscitation that can clear away heart-fire rouses oneself
Mood, decompression are recovered from fatigue.
In cosmetic applications, herbal composite of the invention can be applied to various forms.For example, in of the invention
It is any applied to human body that herbal-composition can be applied to mildy wash, toner, lotion, cream, gel, facial mask, shower cream etc.
The dosage form of skin.
Below with reference to specific embodiment, the present invention is further explained.It should be appreciated, however, that these embodiments are only used for
It is bright the present invention and be not meant to limit the scope of the invention.The test method of actual conditions is not specified in the following example, usually
According to normal conditions, or according to the normal condition proposed by manufacturer.Unless otherwise indicated, all percentage and number be by weight
Meter.
The raw material used in embodiment 1-3 is commercially available fructus alpiniae oxyphyllae essential oil, commercial glucose shaddock oil, commercially available cardamom essential oil, city
Sell fructus lycii essential oil, commercially available Peppermint essential oil.Also, the ratio in comparative example and embodiment 1-3 is percent by volume.
Fructus alpiniae oxyphyllae essential oil, grapefruit essential oil used in the present invention, cardamom essential oil, fructus lycii essential oil, Peppermint essential oil are purchased from
Mans (Shanghai) flavors and fragrances Co., Ltd.
Comparative example: herbal composite screening
Theoretical prescription: according to " monoblock type maintenance " principles of formulating prescriptions of innovative Chinese Fragrant, it is comprehensive embody effect and
Fragrance, first selection, which have to refresh oneself, rouses oneself " monarch " ingredient of effect, and considers the stereovision of fragrance, obtains following optional
Prescription scheme:
Prescription 1, by fructus alpiniae oxyphyllae: grape fruit: fructus lycii=25:22:18 volume ratio calculates under room temperature ventilation state
The drop number of good above-mentioned required essential oil, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly, it is spare.
Prescription 2, by fructus alpiniae oxyphyllae, grape fruit, fructus lycii, cardamom=25:22:18:20 volume ratio, in room temperature ventilation state
Under, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly, it is spare.
Prescription 3, by fructus alpiniae oxyphyllae, grape fruit, fructus lycii, peppermint=25:22:18:15 volume ratio, in room temperature ventilation state
Under, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock uniformly, it is spare.
Prescription 4, by fructus alpiniae oxyphyllae, grape fruit, fructus lycii, cardamom, peppermint=25:22:18:20:15 volume ratio, in room temperature
Under ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, after covering tightly bottle stopper, rock
It is even, it is spare.
Above-mentioned prescription is carried out to hear fragrant test, is tested to the hobby sense of fragrance and the instant impression rouse oneself of refreshing oneself.Method
Are as follows: 15 subjects (25-50 years old, health is without essential oil or champignon allergies) are chosen, inform that test first 12 hours can not
Smoke, take in maror and drink drinks, the drink containing pungents such as caffeines.In mood tranquility, Yu Gu
Fixed quiet airspace, successively open 4 prescriptions essential oil bottle cap, carry out smelling, judgement immediately to the hobby sense of fragrance with
And whether Wen Xianghou there is instant refreshing oneself to rouse oneself impression.It counts each one favorite fragrance prescription and most refreshes oneself and rouse oneself
Immediately the prescription experienced, as a result such as following table.
| Fragrance hobby sense | Refresh oneself and rouses oneself instant impression | |
| Prescription 1 | 2 | 2 |
| Prescription 2 | 2 | 3 |
| Prescription 3 | 3 | 3 |
| Prescription 4 | 8 | 7 |
In upper table, the scoring the high then to indicate better to the hobby of fragrance, and refreshing oneself, it is also better to rouse oneself impression immediately.
As it can be seen that for scheme 4, either blending as a result, the instant impression rouse oneself of still refreshing oneself all is substantially better than remaining
Three prescriptions, therefore selection scheme 4 enters test in next step.
Embodiment 1: the preparation of herbal composite
Take fructus alpiniae oxyphyllae essential oil 25%, grapefruit essential oil 22%, cardamom essential oil 20%, fructus lycii essential oil 18%, Peppermint essential oil
15%, under room temperature ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, cover tightly bottle
After plug, rock uniformly, it is spare.
Embodiment 2: the preparation of herbal composite
Take fructus alpiniae oxyphyllae essential oil 28%, grapefruit essential oil 20%, cardamom essential oil 18%, fructus lycii essential oil 20%, Peppermint essential oil
14%, under room temperature ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, cover tightly bottle
After plug, rock uniformly, it is spare.
Embodiment 3: the preparation of herbal composite
Take fructus alpiniae oxyphyllae essential oil 17%, grapefruit essential oil 23%, cardamom essential oil 28%, fructus lycii essential oil 14%, Peppermint essential oil
18%, under room temperature ventilation state, the drop number of above-mentioned required essential oil is calculated, it is successively accurate to instill in empty Ethereal oil bottle, cover tightly bottle
After plug, rock uniformly, it is spare.
Embodiment 4: efficacy detection
Have chosen 120 student enrollment, wherein 2 group 30 of 30 people of " Chinese Fragrant " example 1 group, " Chinese Fragrant " embodiment
People, 3 group of 30 people of " Chinese Fragrant " embodiment, 30 people of blank control group.University student have passed through stringent choice before enrollment, select mark
Standard includes:
(1) age 18 is more than one full year of life；
(2) enter the preceding physical examination health of group；
(3) enter in group first 1 month without great Psychomotor test Battrey event；
(4) allergies are used without any stacte, essential oil；
(5) voluntarily receive subject, be able to cooperate and receive coherence check and sign informed consent form.
Before experiment, tester is apprised of test and can not smoke, take in maror and drink drinks, contain for first 12 hours
The drink of the pungents such as caffeine.Test in one week should not strenuous exercise, stay up late, be engaged in the work excessive to Psychological stimulation
It is dynamic.
The daily 19:00-20:00 of fragrant experimental selection is heard as the fragrant time is heard, and hearing the fragrant period is 7 days.Test saliva sample
Acquisition be divided into twice, acquisition for the first time first time hear it is fragrant before carry out, second of acquisition last time hear it is fragrant after carry out, will
It acquires saliva sample and carries out SIgA content in saliva and salivary cortisol measurement.
By " Chinese Fragrant " experiment group name university student tissue to the interior space of fixed quiet two isolation, around without suction
Cigarette, the crowd for spraying perfume, do not interfere with each other between experimental group.Wen Xiang starts previous hour, and researcher uses electronic atomizing machine
Essential oil is allowed to fill entire space, and sustained release fragrance during the experiment.University student Wen Xiangshi is engaged in reading, close the eyes for rest or
The other activities of releiving of person.Blank control group focuses on another equivalent interior space, using the tasteless diffusion conduct pair of pure water
According to.
And Scale and questionnaire is carried out to each group crowd before and after experiment.Assessed using international and domestic general mental scale " in
Effect of the state's perfume " for university student's physical and mental health.The scale that this research uses includes Pittsburgh Sleep Quality Index questionnaire and shape
State-Trait anxiety questionnaire.
Experimental result
(1) SIgA content in saliva
Experiment acquisition is divided into twice, and first time, which acquires, hears fragrant preceding progress in first time, and second of acquisition is in last time news
It is carried out after perfume (or spice).First 10 minutes of acquisition, experimental subjects is gargled with clear water.Saliva is acquired using saliva sliver collection tube, collection tube
Top be one can take out below with foraminate tubule, have a sliver to infiltrate saliva inside tubule, be centrifuged
Afterwards, saliva can flow to the bottom end of saliva sliver collection tube by aperture.Sliver is placed in sublingual about 2 minutes by experimental subjects, to cotton
Item is put back in the tubule of collection tube after saliva complete wetting, carries out centrifugation 15min using 3000 rpms of (rpm) speed,
Saliva after centrifugation flows to the bottom end of saliva sliver collection tube by aperture, collects saliva about 6ml (at least 4ml), is stored in saliva
Liquid sliver collection tube, and refrigerate immediately.The refrigerator-freezer that the saliva sliver collection tube that centrifugation finishes is sent to -20 DEG C in 30min is frozen
It deposits, is detected in 15 days.Under normal circumstances, the concentration of cortisol in blood is significantly larger than salivary cortisol concentration, because
This blood pollutes the measurement result that can seriously affect salivary cortisol, so experimenter checks saliva using naked eyes one by one after acquisition
Liquid sliver by intraoral blood whether there is or not being polluted, such as bleeding gums, by the research pair if saliva sliver is contaminated by the blood
As rejecting not meet test requirements document person, does not continue to participate in experiment, be filled by candidate research object.Using solidification enzyme linked immunological
Adsorption measurement (Enzyme linked immunosorbent assay, ELISA) kit detects SIgA content.
The following table 1 shows that Wen Xiangqian (the 0th day) and Wen Xianghou (the 7th day) experimental subjects SIgA content in saliva content (μ g/ml) become
Change.
Table 1
* p < 0.05 indicates significant sex differernce；* p < 0.01. indicates extremely significant sex differernce.
The comparable state for delicately reflecting human body non-specific immune function of SIgA content in saliva level.Immunologic hypofunction
Crowd SIgA level also accordingly declines.In this test, SIgA content and experiment of the embodiment group before experiment starts in saliva are tied
Significant difference is presented in SIgA content after beam, and the SIgA of " Chinese Fragrant " embodiment group after the end of the experiment and control group are tested simultaneously
After SIgA content significant difference is presented.Experimental subjects is after smelling " Chinese Fragrant " Example formulations 1, and SIgA contains in saliva
Amount obviously increases that (mean value is promoted by 28.42 μ g/ml to 32.15 μ g/ml)；Experimental subjects is in smelling " Chinese Fragrant " Example formulations
After 2, SIgA content obviously increases that (mean value is promoted by 28.42 μ g/ml to 34.18 μ g/ml) in saliva；Experimental subjects is in smelling
After " Chinese Fragrant " Example formulations 3, SIgA content obviously increases that (mean value is promoted by 28.57 μ g/ml to 35.25 μ g/ in saliva
Ml) illustrate that " Chinese Fragrant " each group Example formulations are remarkably reinforced the resistance of body immunity, alien bacteria, virus etc..
(2) salivary cortisol
Experiment acquisition is divided into twice, and first time, which acquires, hears fragrant preceding progress in first time, and second of acquisition is in last time news
It is carried out after perfume (or spice).First 10 minutes of acquisition, experimental subjects is gargled with clear water.Saliva is acquired using saliva sliver collection tube, collection tube
Top be one can take out below with foraminate tubule, have a sliver to infiltrate saliva inside tubule, be centrifuged
Afterwards, saliva can flow to the bottom end of saliva sliver collection tube by aperture.Sliver is placed in sublingual about 2 minutes by experimental subjects, to cotton
Item is put back in the tubule of collection tube after saliva complete wetting, carries out centrifugation 15min using 3000 rpms of (rpm) speed,
Saliva after centrifugation flows to the bottom end of saliva sliver collection tube by aperture, collects saliva about 6ml (at least 4ml), is stored in saliva
Liquid sliver collection tube, and refrigerate immediately.The refrigerator-freezer that the saliva sliver collection tube that centrifugation finishes is sent to -20 DEG C in 30min is frozen
It deposits, is detected in 15 days.Under normal circumstances, the concentration of cortisol in blood is significantly larger than salivary cortisol concentration, because
This blood pollutes the measurement result that can seriously affect salivary cortisol, so experimenter checks saliva using naked eyes one by one after acquisition
Liquid sliver by intraoral blood whether there is or not being polluted, such as bleeding gums, by the research pair if saliva sliver is contaminated by the blood
As rejecting not meet test requirements document person, does not continue to participate in experiment, be filled by candidate research object.Using solidification enzyme linked immunological
Adsorption measurement (Enzyme linked immunosorbent assay, ELISA) kit detects salivary cortisol content.
The following table 2 shows Wen Xiangqian (the 0th day) and Wen Xianghou (the 7th day) experimental subjects salivary cortisol concentration (pmol/
Ml) change.
Table 2
* p < 0.05 indicates significant sex differernce；* p < 0.01. indicates extremely significant sex differernce.
Cortisol is able to maintain that the normal physiological function of pressure state lower body；If lacking cortisol, body if, can not
Effecting reaction is made to pressure.It is chronically under pressure state, cortisol levels can be made higher, it can not normal regulating.Such as table institute
Show, SIgA content of " Chinese Fragrant " the embodiment each group after concentration of cortisol and experiment before experiment starts in saliva is presented
Extremely significant difference, the cortisol after the SIgA of " Chinese Fragrant " each embodiment group after the end of the experiment and control group are tested simultaneously
Extremely significant difference is presented in concentration.Embodiment group 1, hear it is fragrant after salivary cortisol obviously increase (mean value by 735pmol/ml promoted to
951pmol/ml)；Embodiment group 2, hear it is fragrant after salivary cortisol obviously increase that (mean value is promoted by 740pmol/ml to 933pmol/
ml)；Embodiment group 1, hear it is fragrant after salivary cortisol obviously increase that (mean value is promoted by 755pmol/ml to 949pmol/ml).Sufficiently
Show that " Chinese Fragrant " Example formulations have remarkable effect for the increase of experimental subjects Determination of cortisol, facilitates human immunity
The promotion of power, resistance, the anti-pressure ability of significant enhancing human body.
(3) scale is evaluated and tested:
This research uses Pittsburgh Sleep scale, state-feature anxiety questionnaire to assess " Chinese Fragrant " embodiment group pair
In the effect of human body unhealthy emotion (spirit) state.
Pittsburgh Sleep scale can be from time for falling asleep/sleep duration/Sleep efficiency etc. Comprehensive evaluation experimental
The sleep quality of object.By 7 parts, totally 19 problems form scale, and total score is 0~21 point, and (0 point represents no sleep and asks
Topic, 21 points represent sleeping problems very serious), this test mainly uses the total score of scale, carrys out globality reflection " Chinese Fragrant "
Influence to sleep quality.
As shown in table 3 below, ascendant trend is presented in the sleep index scores of " Chinese Fragrant " embodiment group, and each group has about 0.5
Divide and rise, is consistent with the expection effect to refresh the mind.The effect of tentative confirmation " Chinese Fragrant " Example formulations.
Pittsburgh Sleep index scale (PSQI) (average mark) result after table 3: Wen Xiangqian and Wen Xiang
* p < 0.05 indicates significant sex differernce；* p < 0.01 indicates extremely significant sex differernce.
Based on the correlation analysis of state-feature anxiety questionnaire (STAI) data
State-feature anxiety questionnaire can measure situational anxiety and trait anxiety simultaneously, contain as a kind of Self-assessment Scale
Two subscales of state anxiety questionnaire (S-AI) and Trait anxiety questionnaire (T-AI), respectively there is 20 estimation items.State anxiety description
A kind of is usually the offending emotional experience of transience, such as nervous, worried, frightened and neurotic, with the function of nervous system
It can be hyperfunction.A trait be then used to describe it is metastable, as a kind of personal traits and with individual difference anxiety be inclined to.
Following table 4-5 is the scale result for reflecting experimental subjects anxiety.As can be seen that " Chinese Fragrant " embodiment is each
Group all shows apparent improvement result for two kinds of unhealthy emotion symptoms of state anxiety and feature anxiety.Wen Xianghou, embodiment 1
The scoring of group state anxiety and feature anxiety scores decline 6 points or so, and 2 groups of state anxieties of embodiment score and feature anxiety scores
Decline 5 points or so, 3 groups of state anxiety scorings of embodiment and feature anxiety scores decline 4 points or so.
The sub- scale of state anxiety (S-AI) (average mark) result after table 4: Wen Xiangqian and Wen Xiang
* p < 0.05 indicates significant sex differernce；* p < 0.01. indicates extremely significant sex differernce
The sub- scale of feature anxiety (T-AI) (average mark) result after table 5: Wen Xiangqian and Wen Xiang
* p < 0.05 indicates significant sex differernce；* p < 0.01. indicates extremely significant sex differernce.
Embodiment 5:3GC-MS gas-chromatography composition test
By saliva physical signs and mental scale index determining and analysis, in order to be best understood from the embodiment compound essence
Effect principle of oil, and carried out GC-MS detection.
Instrument main working parameters: LECO company of U.S. comprehensive two dimensional gas chromatography-flight time mass spectrum 7890GC/
Pegasus 4D GCxGC-TOFMS；First dimension chromatographic column: DB-5MS (30m × 0.25mm × 0.25 μm)；Injector temperature: 270
℃；Sample volume: 1.0 μ L；Column temperature: 60 DEG C of holding 3.0min rise to 280 DEG C with 4.0 DEG C/min, keep 2.5min；Nebulizer gas pressure
Or flow: 1.0mL/min；Split ratio: without shunting；Helium (99.999%)；Second dimension chromatographic column: DB-17MS (2m × 0.10mm
×0.10μm)；The modem period: 4.0s；Column temperature: 10 DEG C of one-dimension temperature are consistently higher than；Modem temperature: always
Higher than 15 DEG C of two-dimension temperature；Interface temperature: 270 DEG C；Ion source temperature: 220 DEG C；Ionization mode: electron bombardment ionization source；Electronics times
Increase device: 1800V；Scanning mode: 30-550amu；NIST2011 composes library.GC × GC- of two kinds of essential oils is delineated by detecting
The TIC of the TIC X-Y scheme of TOFMS, tri- bitmap of TIC of GC × GC-TOFMS and GC × GC-TOFMS schemes.Fig. 1-3 is shown
The TIC X-Y scheme, TIC three-dimensional figure and TIC figure of " Chinese Fragrant " embodiment 2.
1 surveyed ingredient 1233 of " Chinese Fragrant " embodiment, wherein similarity is greater than 600, and possibility is higher than 4000, and component is total
511, constituent analysis has been obtained by further screening (component content is greater than 1%), the results are shown in Table 6:
Table 6: the Principle components analysis of " Chinese Fragrant " embodiment 1
As can be seen that " Chinese Fragrant " embodiment 1 is based on alcohols and vinyl compound from ingredient, therefore has and improve body
The heart, the effect for exciting body energy.The effect to refresh the mind with " Chinese Fragrant " embodiment is consistent, the effect to refresh the mind for
The adjusting of university student emotion plays positive acting, and mood is made to tend to be optimistic positive, acts on forced, psychotic disease, anxiety, fears
In a variety of unhealthy emotions such as fear, comprehensive effect is produced.
Compound essential oil produced by the present invention is used for domestic chemical products, can be used as efficacy active component or flavors and fragrances
It uses, fragrance faint scent is happy pure and fresh lively.It is any that application form can be mildy wash, bath oil, lotion, cream, shampoo etc.
It can be applied to the dosage form of human skin, it is as follows.
The preparation (including day cream and late frost) of 6 face cream of embodiment
Embodiment 7: the preparation of lotion
Embodiment 8: the preparation of facial mask
Embodiment 9: the preparation of shower cream
Claims (8)
1. a kind of inducing resuscitation and/or rouse oneself mood and/or the herbal composite that recovers from fatigue of decompression for clearing away heart-fire, according to the Chinese herbal medicine
The total volume meter of composition, the composition are made of following components:
The fructus alpiniae oxyphyllae essential oil of 15-30 volume %；
The grapefruit essential oil of 20-25 volume %；
The cardamom essential oil of 15-30 volume %；
The fructus lycii essential oil of 10-20 volume %；
The Peppermint essential oil of 10-20 volume %；
Wherein, the sum of each component is 100 volume % in the composition.
2. herbal composite as described in claim 1, which is characterized in that the composition is made of following components:
The fructus alpiniae oxyphyllae essential oil of 17-28 volume %；
The grapefruit essential oil of 20-23 volume %；
The cardamom essential oil of 18-20 volume %；
The fructus lycii essential oil of 14-20 volume %；
The Peppermint essential oil of 14-18 volume %.
3. herbal composite as claimed in claim 1 or 2, the herbal composite includes fructus alpiniae oxyphyllae essential oil, grape fruit
Essential oil, cardamom essential oil, fructus lycii essential oil and Peppermint essential oil, according to the total volume meter of the herbal composite, the composition packet
Containing 7.491% amphene, 2.964% laurene, 5.586% firpene, 1.769% p-cymene, 9.980% limonene, 1.205% pine tar
Alkene -4- alcohol, 5.033% terpinol, 3.436% carveol, 4.902% linalool, 6.688% carvol, 18.232% 7- octene -2-
Alcohol, 2- methyl -6- methylene-dihydromyrcenol, 1.961% geranyl acetate, 2.642% caryophyllene oxide.
4. herbal composite as claimed in any one of claims 1-3 inducing resuscitation and/or rouses oneself mood for clearing away heart-fire in preparation
And/or the purposes in the skin preparations for extenal use that recovers from fatigue of decompression.
5. a kind of skin preparations for extenal use comprising herbal composite as claimed in any one of claims 1-3.
6. skin preparations for extenal use as claimed in claim 5, which is characterized in that described with the total weight of the skin preparations for extenal use
The dosage of herbal composite is 0.001-20%.
7. skin preparations for extenal use as claimed in claim 6, which is characterized in that described with the total weight of the skin preparations for extenal use
The dosage of herbal composite is 0.001-10%.
8. skin preparations for extenal use as claimed in claim 7, which is characterized in that described with the total weight of the skin preparations for extenal use
The dosage of herbal composite is 0.01-5%.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101010091A (en) * | 2004-09-02 | 2007-08-01 | 宝洁公司 | Oral care composition comprising essential oils |
| CN103637201A (en) * | 2013-12-10 | 2014-03-19 | 大连创达技术交易市场有限公司 | Mind refreshing oil |
| CN104250583A (en) * | 2013-06-28 | 2014-12-31 | 青岛联合创新技术服务平台有限公司 | Compound essential oil |
| CN104288814A (en) * | 2014-09-19 | 2015-01-21 | 明光瑞泰工业有限公司 | Safe and practical air freshener |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101010091A (en) * | 2004-09-02 | 2007-08-01 | 宝洁公司 | Oral care composition comprising essential oils |
| CN104250583A (en) * | 2013-06-28 | 2014-12-31 | 青岛联合创新技术服务平台有限公司 | Compound essential oil |
| CN103637201A (en) * | 2013-12-10 | 2014-03-19 | 大连创达技术交易市场有限公司 | Mind refreshing oil |
| CN104288814A (en) * | 2014-09-19 | 2015-01-21 | 明光瑞泰工业有限公司 | Safe and practical air freshener |
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