CN105287816A - Preparation which contains crocodile extracts and is used for clearing lung to stop coughing and preparation method thereof - Google Patents
Preparation which contains crocodile extracts and is used for clearing lung to stop coughing and preparation method thereof Download PDFInfo
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- CN105287816A CN105287816A CN201510717199.4A CN201510717199A CN105287816A CN 105287816 A CN105287816 A CN 105287816A CN 201510717199 A CN201510717199 A CN 201510717199A CN 105287816 A CN105287816 A CN 105287816A
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Abstract
The invention discloses a preparation which contains crocodile extracts and is used for clearing the lung to stop coughing and a preparation method thereof and aims at providing a preparation which is used for enhancing immunity and moistening the lung to stop coughing and contains crocodile extracts and a preparation method thereof. The preparation is technically characterized in that the preparation comprises, by weight, 10-90 parts of a crocodile meat extracting solution, 10-30 parts of siraitia grosvenorii, 10-20 parts of green plums, 5-15 parts of dark plums, 5-15 parts of mint, 5-10 parts of red oranges and 3-8 parts of licorice. The invention belongs to the technical field of medicine.
Description
Technical field
The present invention discloses a kind of compositions of clearing away lung-heat to relieve cough, specifically, is a kind of crocodile extractive composition of clearing away lung-heat to relieve cough, belongs to medical art.
Background technology
Cough is a kind of important defense mechanism of human body, stimulate, or harmful gas sucks, or when foreign body is strayed into air flue accidentally, just cause cough, therefore cough is a kind of guarding reflex when respiratory mucosa is subject to too much secretions.Cough significantly can increase intrathoracic pressure and expiration speed and have an impact to hemodynamics; it is a kind of guarding reflex; can effectively remove the respiratory tract factor; or assist maintenance patient to realize even conversion when there is severe arrhythmia; play the effect of spontaneity " cardio-pulmonary resuscitation "; but it is also the clinical symptoms that numerous disease occurs, is one of modal disease main suit simultaneously.Frequent and long-term cough can make to infect diffusion in respiratory tract; Impact sleep, consumes one's strength; Make to send out containing the former secretions that causes a disease, cause pathophoresis; Bring out the complication of multiple systems such as cardiovascular, nerve, digestive tract, breathing.Therefore, the diagnosis and treatment of cough receive great attention in the world.
Crocodile and dinosaur contemporary, be one of animal the most ancient on the earth, have the title of " living fossil ".One of animal of crocodile longest-lived simultaneously or on the earth, the life-span up to more than 200 year old, than Testudinis and Trionyx sinensis Wiegmann also long.In addition, the animal that on crocodile or the earth, the bodily form is maximum, find that maximum crocodile fish length has 12 meters at present in Africa, weight is up to 8.The Shennong's Herbal of Qin-Han times claims crocodile to be Tuo fish, and cure mainly trusted subordinate's lump in the abdomen, Fu Jian gathers, cold and heat, woman's metrorrhagia hematochezia five colors, phase dragging pain in lower abdomen the moon, the dead flesh of scabies.Record crocodile first soup in the Thousand Golden Prescriptions of the Tang Dynasty " king of medicine " Sun Simiao to cure mainly " wind is insane ".
Summary of the invention
The object of the present invention is to provide a kind of increase immunity, crocodile extract formulation of nourishing the lung to arrest cough and preparation method thereof.
For solving the problems of the technologies described above, last technical scheme provided by the invention is such: described preparation is containing the crude drug of following weight parts: crocodile meat extracting solution 10-90 part, Fructus Momordicae 10-30 part, Armeniaca mume Sieb. 10-20 part, Fructus Mume 5-15 part, Herba Menthae 5-15 part, Exocarpium Citri Rubrum 5-10 part, Radix Glycyrrhizae 3-8 part.
Further, the above-mentioned clearing away lung-heat to relieve cough preparation containing crocodile extract, described preparation is containing the crude drug of following weight parts: crocodile meat extracting solution 30-70 part, Fructus Momordicae 15-25 part, Armeniaca mume Sieb. 12-18 part, Fructus Mume 8-12 part, Herba Menthae 8-12 part, Exocarpium Citri Rubrum 6-9 part, Radix Glycyrrhizae 4-7 part.
In order to prepare said preparation, after provided by the invention, a technical scheme is such:
Should comprise the steps: successively containing the preparation method of the clearing away lung-heat to relieve cough preparation of crocodile extract
1) first crocodile meat extracting solution is extracted;
2) each component is taken;
3) by step 2) Fructus Momordicae that takes, Armeniaca mume Sieb., Fructus Mume, Fructus Citri tangerinae is red, Radix Glycyrrhizae, Herba Menthae puts into extraction pot, use soak by water secondary, each water consumption is the 5-7 times amount of medical material weight, each 60 ~ 90 minutes, filter, merging filtrate and be condensed into 60-65 DEG C survey relative density be the clear paste of 1.10-1.25, adding ethanol to making containing amount of alcohol is 20-40%, stir evenly, leave standstill 12 hours, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 40-50%, add step 1) the crocodile meat extracting solution prepared, antiseptic, stock solution embedding, irradiation sterilization, packed products, make oral liquid, obtain.
Further, the preparation method of the above-mentioned clearing away lung-heat to relieve cough preparation containing crocodile extract, the extracting method of described crocodile meat extracting solution comprises the steps: successively
1) take crocodile meat, grind, 1:1 adds water in mass ratio, boils rear maintenance 15min and is placed on 4 DEG C of coolings, is removed by the oils and fats of cooling after coagulation in upper strata, prepares muddy flesh;
2) mass ratio muddy flesh and distilled water being pressed 1:1 loads in flask, is placed in water bath with thermostatic control and carries out enzymolysis 1-5h;
3), after enzymolysis terminates, in 80 DEG C of water-baths, be incubated 20min make enzyme deactivation;
4) enzymolysis solution after enzyme denaturing is cooled to room temperature, removes unhydrolysed muddy flesh, then at 4 DEG C, 10000r/min centrifugalize 15min, removing solid matter, collects supernatant.
Further, the preparation method of the above-mentioned clearing away lung-heat to relieve cough preparation containing crocodile extract, the enzyme adopted during described enzymolysis be composite animal albumen enzyme or alkaline protease or pepsin or neutral protease or tryptic one of them.
Further, the preparation method of the above-mentioned clearing away lung-heat to relieve cough preparation containing crocodile extract, step 2) described in enzymolysis enzyme and the mass ratio of muddy flesh be: 1:0.005-0.01.
Compared with prior art, in technical scheme provided by the invention, crocodile meat extracting solution cures mainly few breathing, enough not on the spot, dampness pathogen, in its abdomens all, disease painful abdominal mass malignant boil; Fructus Momordicae sweet in the mouth is cool in nature, returns lung, large intestine channel, has nourishing the lung to arrest cough, and effect of promoting the production of body fluid to quench thirst is applicable to lung-heat or xeropulmonary cough; Exocarpium Citri Rubrum is pungent can walk crosswise eliminating stagnation, bitter decline of keeping straight on, and be promoting the circulation of QI key medicine, controlling expectorant must regulate the flow of vital energy, the spontaneous recovery of diarrhea due to disorder of QI expectorant, therefore with entering lung spleen, all expectorant main are sick, and merit occupies on all expectorant medicines; Radix Glycyrrhizae warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, quenches the thirst, qualcomm meridian, and sharp vim and vigour separate hundred poison of drug; Fructus Mume is astringed the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris, and a few person's scientific compatibility, has good nourishing the lung to arrest cough, resolve phlegm effect; And be added with Armeniaca mume Sieb., Herba Menthae, mouthfeel is unique, abundant.
Detailed description of the invention
Below in conjunction with detailed description of the invention; claim of the present invention is described in further detail; but become any limitation of the invention not, the amendment of anyone limited number of time made within the scope of the claims in the present invention, still at claims of the present invention.
Embodiment 1
A kind of clearing away lung-heat to relieve cough preparation containing crocodile extract provided by the invention, described preparation is containing following raw material medicaments: crocodile meat extracting solution 90g, Fructus Momordicae 30g, Armeniaca mume Sieb. 10g, Fructus Mume 15g, Herba Menthae 5g, Exocarpium Citri Rubrum 10g, Radix Glycyrrhizae 3g.
Embodiment 2
Another kind provided by the invention is containing the clearing away lung-heat to relieve cough preparation of crocodile extract, and described preparation is containing following raw material medicaments: crocodile meat extracting solution 10g, Fructus Momordicae 30g, Armeniaca mume Sieb. 10g, Fructus Mume 15g, Herba Menthae 5g, Exocarpium Citri Rubrum 5g, Radix Glycyrrhizae 8g.
Embodiment 3
A kind of clearing away lung-heat to relieve cough preparation containing crocodile extract provided by the invention, described preparation is containing following raw material medicaments: crocodile meat extracting solution 30g, Fructus Momordicae 25g, Armeniaca mume Sieb. 12g, Fructus Mume 12g, Herba Menthae 8g, Exocarpium Citri Rubrum 9g, Radix Glycyrrhizae 4g.
Embodiment 4
A kind of clearing away lung-heat to relieve cough preparation containing crocodile extract provided by the invention, the crude drug under described preparation contains: crocodile meat extracting solution 70g, Fructus Momordicae 15g, Armeniaca mume Sieb. 18g, Fructus Mume 8g, Herba Menthae 12g, Exocarpium Citri Rubrum 6g, Radix Glycyrrhizae 7g.
Embodiment 5
A kind of clearing away lung-heat to relieve cough preparation containing crocodile extract provided by the invention, described preparation is containing following raw material medicaments: crocodile meat extracting solution 50g, Fructus Momordicae 20g, Armeniaca mume Sieb. 15g, Fructus Mume 10g, Herba Menthae 10g, Exocarpium Citri Rubrum 8g, Radix Glycyrrhizae 5g.
In embodiment 1 to 5 any one group containing the preparation method of clearing away lung-heat to relieve cough preparation of crocodile extract, comprise the steps: successively
1) first crocodile meat extracting solution is extracted;
2) each component is taken by one group of mass number any in embodiment 1 to 5;
3) by step 2) Fructus Momordicae that takes, Armeniaca mume Sieb., Fructus Mume, Fructus Citri tangerinae is red, Radix Glycyrrhizae, Herba Menthae puts into extraction pot, use soak by water secondary, each water consumption is the 5-7 times amount of medical material weight, decoct secondary, each 60 ~ 90 minutes, filter, filtrate is condensed into and surveys relative density at 60-65 DEG C is the clear paste of 1.10-1.25, adding ethanol to making containing amount of alcohol is 20-40%, stir evenly, leave standstill 12 hours, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 40-60%, add step 1) the crocodile meat extracting solution prepared, stock solution embedding, irradiation sterilization, packed products (often propping up 10ml), make oral liquid, obtain.
Wherein: the extracting method of described crocodile meat extracting solution comprises the steps: successively
1) take crocodile meat, grind, 1:1 adds water in mass ratio, boils rear maintenance 15min and is placed on 4 DEG C of coolings, is removed by the oils and fats of cooling after coagulation in upper strata, prepares muddy flesh;
2) mass ratio muddy flesh and distilled water being pressed 1:1 loads in flask, is placed in water bath with thermostatic control and carries out enzymolysis 1-5h;
3), after enzymolysis terminates, in 80 DEG C of water-baths, be incubated 20min make enzyme deactivation;
4) enzymolysis solution after enzyme denaturing is cooled to room temperature, removes unhydrolysed muddy flesh, then at 4 DEG C, 10000r/min centrifugalize 15min, removing solid matter, collects supernatant.
The enzyme adopted during above-mentioned enzymolysis be composite animal albumen enzyme or alkaline protease or pepsin or neutral protease or tryptic one of them; Step 2) described in enzymolysis enzyme and the mass ratio of muddy flesh be: 1:0.005-0.01.
In order to effect of the present invention is better described, provide case of the present invention experiment below:
Case 1
Magnify grandfather, 60 years old, retired worker, cough for many years, takes the continuous two weeks of clearing away lung-heat to relieve cough preparation provided by the invention, and every day each one sooner or later, situation is clearly better.
Case 2
Miss Li, 28 years old, white collar, the cough caused of catching a cold, took clearing away lung-heat to relieve cough preparation provided by the invention continuous three days, and every day each one sooner or later, symptom disappears completely.
Case 3
Mr. Zhang, 50 years old, workman, because of long-term dust exposure impurity, easily coughed, and took the continuous two weeks of clearing away lung-heat to relieve cough preparation provided by the invention, every day each one sooner or later, had no cough symptom in half a year.
Case 4
King classmate, 15 years old, student, the cough caused of catching a cold, took clearing away lung-heat to relieve cough preparation provided by the invention continuous three days, and every day each one sooner or later, symptom disappears completely.
Claims (6)
1. containing a clearing away lung-heat to relieve cough preparation for crocodile extract, it is characterized in that, described preparation is containing the crude drug of following weight parts: crocodile meat extracting solution 10-90 part, Fructus Momordicae 10-30 part, Armeniaca mume Sieb. 10-20 part, Fructus Mume 5-15 part, Herba Menthae 5-15 part, Exocarpium Citri Rubrum 5-10 part, Radix Glycyrrhizae 3-8 part.
2. the clearing away lung-heat to relieve cough preparation containing crocodile extract according to claim 1, is characterized in that, described preparation is containing the crude drug of following weight parts: crocodile meat extracting solution 30-70 part, Fructus Momordicae 15-25 part, Armeniaca mume Sieb. 12-18 part, Fructus Mume 8-12 part, Herba Menthae 8-12 part, Exocarpium Citri Rubrum 6-9 part, Radix Glycyrrhizae 4-7 part.
3. the preparation method of the clearing away lung-heat to relieve cough preparation containing crocodile extract described in claim 1 or 2, is characterized in that, comprise the steps: successively
1) first crocodile meat extracting solution is extracted;
2) each component is taken by the mass number described in claim 1 or 2;
3) by step 2) Fructus Momordicae that takes, Armeniaca mume Sieb., Fructus Mume, Fructus Citri tangerinae is red, Radix Glycyrrhizae, Herba Menthae puts into extraction pot, use soak by water secondary, each water consumption is the 5-7 times amount of medical material weight, each 60 ~ 90 minutes, filter, merging filtrate and be condensed into 60-65 DEG C survey relative density be the clear paste of 1.10-1.25, adding ethanol to making containing amount of alcohol is 20-30%, stir evenly, leave standstill 12 hours, filter, get filtrate recycling ethanol, be condensed into the extractum containing solid weight 40-50%, add step 1) the crocodile meat extracting solution prepared, antiseptic, stock solution embedding, irradiation sterilization, packed products, make oral liquid, obtain.
4. the preparation method of the clearing away lung-heat to relieve cough preparation containing crocodile extract according to claim 3, it is characterized in that, the extracting method of described crocodile meat extracting solution comprises the steps: successively
1) take crocodile meat, grind, 1:1 adds water in mass ratio, boils rear maintenance 15min and is placed on 4 DEG C of coolings, is removed by the oils and fats of cooling after coagulation in upper strata, prepares muddy flesh;
2) mass ratio muddy flesh and distilled water being pressed 1:1 loads in flask, is placed in water bath with thermostatic control and carries out enzymolysis 1-5h;
3), after enzymolysis terminates, in 80 DEG C of water-baths, be incubated 20min make enzyme deactivation;
4) enzymolysis solution after enzyme denaturing is cooled to room temperature, removes unhydrolysed muddy flesh, then at 4 DEG C, 10000r/min centrifugalize 15min, removing solid matter, collects supernatant.
5. the preparation method of the clearing away lung-heat to relieve cough preparation containing crocodile extract according to claim 4, it is characterized in that, the enzyme adopted during described enzymolysis be composite animal albumen enzyme or alkaline protease or pepsin or neutral protease or tryptic one of them.
6. the preparation method of the clearing away lung-heat to relieve cough preparation containing crocodile extract according to claim 4, is characterized in that, step 2) described in enzymolysis enzyme and the mass ratio of muddy flesh be: 1:0.005-0.01.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510717199.4A CN105287816A (en) | 2015-10-28 | 2015-10-28 | Preparation which contains crocodile extracts and is used for clearing lung to stop coughing and preparation method thereof |
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| CN201510717199.4A CN105287816A (en) | 2015-10-28 | 2015-10-28 | Preparation which contains crocodile extracts and is used for clearing lung to stop coughing and preparation method thereof |
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| CN105287816A true CN105287816A (en) | 2016-02-03 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106360664A (en) * | 2016-08-15 | 2017-02-01 | 湛江广医医药科技开发有限公司 | Exocarpium Citri Rubrum health food with effects of relieving cough, resisting bacteria, diminishing inflammation, clearing voice and treating pharyngolaryngitis |
| CN107582664A (en) * | 2017-09-29 | 2018-01-16 | 武汉华士特工业生物技术开发有限公司 | It is a kind of to be used to alleviate compounding extract of chronic cough and preparation method thereof |
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| CN101756286A (en) * | 2010-02-04 | 2010-06-30 | 林峰亮 | Crocodile buccal tablets and preparation method thereof |
| CN103416768A (en) * | 2013-08-15 | 2013-12-04 | 汪华东 | Ziyin Busheng crocodile meat composition and preparation method thereof |
| CN104207146A (en) * | 2014-07-26 | 2014-12-17 | 胡安然 | Total-nutritional formulation food used for respiratory system diseases |
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2015
- 2015-10-28 CN CN201510717199.4A patent/CN105287816A/en active Pending
Patent Citations (3)
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|---|---|---|---|---|
| CN101756286A (en) * | 2010-02-04 | 2010-06-30 | 林峰亮 | Crocodile buccal tablets and preparation method thereof |
| CN103416768A (en) * | 2013-08-15 | 2013-12-04 | 汪华东 | Ziyin Busheng crocodile meat composition and preparation method thereof |
| CN104207146A (en) * | 2014-07-26 | 2014-12-17 | 胡安然 | Total-nutritional formulation food used for respiratory system diseases |
Non-Patent Citations (1)
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| 许东晖等: "鳄鱼止咳膏镇咳、祛痰、抗炎以及免疫调节作用研究", 《中国中药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106360664A (en) * | 2016-08-15 | 2017-02-01 | 湛江广医医药科技开发有限公司 | Exocarpium Citri Rubrum health food with effects of relieving cough, resisting bacteria, diminishing inflammation, clearing voice and treating pharyngolaryngitis |
| CN107582664A (en) * | 2017-09-29 | 2018-01-16 | 武汉华士特工业生物技术开发有限公司 | It is a kind of to be used to alleviate compounding extract of chronic cough and preparation method thereof |
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Application publication date: 20160203 |
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