CN105285474A - Compound Chinese herbal medicine superfine powder, and preparation method and application thereof - Google Patents
Compound Chinese herbal medicine superfine powder, and preparation method and application thereof Download PDFInfo
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- CN105285474A CN105285474A CN201510853455.2A CN201510853455A CN105285474A CN 105285474 A CN105285474 A CN 105285474A CN 201510853455 A CN201510853455 A CN 201510853455A CN 105285474 A CN105285474 A CN 105285474A
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Abstract
The invention discloses a compound Chinese herbal medicine superfine powder, and a preparation method and application thereof. The compound Chinese herbal medicine superfine powder is prepared from hawthorn, radix codonopsitis, astragalus membranaceus, Chinese angelica, eucommia ulmoides, rhizoma cyperi, rheum officinale, atractylodes macrocephala, rhizoma atractylodis, stephania tetrandra and poria cocos. The preparation method comprises the following steps: cleaning all the raw materials, drying, mixing according to a scientific ratio, performing preliminary pulverizing on the mixture through a pulverizer, and performing wall-broken pulverizing on the pulverized mixture through a low-temperature ultrasonic pyrolysis method to enable the diameter of each particle to be 10 microns or below. When the compound Chinese herbal medicine superfine powder is added into a laying hen basal diet, the absorption of laying hens to daily ration nutrition and drugs is accelerated, the blood fat level in the laying hens can be remarkably reduced, the content of cholesterol in eggs can be remarkably reduced, and meanwhile, higher production performance of the laying hens can be kept; the compound Chinese herbal medicine superfine powder has a better popularizing prospect in the production of the low-cholesterol eggs.
Description
Technical field
The present invention relates to poultry feed field, specifically a kind of preparation of compound Chinese herb Ultramicro-powder is extremely applied.
Background technology
Egg is one of source of nutrition best in human foods, but due to high level cholesterol thus limit the consumption of the public to egg.Therefore, utilizing scientific method to produce low-cholesterol egg is major issue urgently to be resolved hurrily.In recent years, Chinese herbal medicine because of the advantages such as its aboundresources, evident in efficacy, toxic and side effect are few increasingly extensive in low-cholesterol egg research, and obtain certain effect.But many doubt are still existed for its mechanism of action.The Chinese herbal medicine of tradition application mostly simultaneously is thick powder, there is using dosage large, affects the shortcomings such as diet nutrition-allocated proportion.Utilize advanced superfine communication technique, exploitation compound Chinese herb Ultramicro-powder, is not only conducive to drug absorption and release, improves bioavilability, and has advantages such as reducing production cost.
In egg, the cholesterol overwhelming majority is from yolk precursor, namely at the lipoprotein of hen liver synthesis, and mainly VLDL (Verylow-densitylipoprotein, VLDL).VLDL is primarily of triglycerides (Triglyceride, TG), cholesterol (Totalcholesterol, TC), phosphatide etc. and apolipoprotein B (ApolipoproteinB, etc. ApoB) combine and formed, function is that TG and TC of transhipment endogenous synthesis is to peripheral tissues.In body, the removing of cholesterol is mainly by HDL (High-densitylipoprotein, HDL) after from peripheral tissues, extracting cholesterol makes its esterification, reverses to transport liver metabolism process back and complete.After compound Chinese herb ultramicro grinding is made an addition to basal diet by the present invention, measuring blood lipid level, Egg cholesterol amount, determining that compound Chinese herb reduces the effect of cholesterol in egg by improving lipid metabolism further.
Summary of the invention
The object of the present invention is to provide a kind of preparation method and application thereof of compound Chinese herb Ultramicro-powder, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of compound Chinese herb Ultramicro-powder, be made up of the raw material of following weight portion: hawthorn 30 ~ 60 parts, Radix Codonopsis 18 ~ 22 parts, the Radix Astragali 26 ~ 33 parts, Radix Angelicae Sinensis 20 ~ 26 parts, the bark of eucommia 5 ~ 13 parts, rhizoma cyperi 7 ~ 11 parts, rheum officinale 4 ~ 10 parts, the bighead atractylodes rhizome 17 ~ 21 parts, rhizoma atractylodis 16 ~ 31 parts, Stephania tetrandra 13 ~ 18 parts, 15 ~ 25 parts, Poria cocos.
A kind of preparation method of compound Chinese herb Ultramicro-powder, concrete preparation process is as follows: cleaned respectively by above-mentioned raw materials after drying, mix according to proportioning, first tentatively pulverize with pulverizer, carry out broken wall pulverizing with low temperature ultrasonic cracking pulverizer again, be ground into the superfines of less than 10 μm.
An application for the compound Chinese herb Ultramicro-powder prepared, this compound Chinese herb Ultramicro-powder is for reducing the cholesterol level in egg.
Compared with prior art, the invention has the beneficial effects as follows: adopt this compound Chinese herb Ultramicro-powder to add in laying hen Basic drawing, promote that laying hen is to the absorption of diet nutrient and medicine, significantly can reduce the blood lipid level in laying hen, and the cholesterol level that can significantly reduce in egg, the production performance that simultaneously laying hen can be kept higher.This compound Chinese herb Ultramicro-powder has good promotion prospect in low-cholesterol egg is produced.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
Compound Chinese herb Ultramicro-powder, is made up of the raw material of following weight: hawthorn 30g, Radix Codonopsis 22g, Radix Astragali 26g, Radix Angelicae Sinensis 26g, bark of eucommia 5g, rhizoma cyperi 11g, rheum officinale 4g, bighead atractylodes rhizome 21g, rhizoma atractylodis 16g, Stephania tetrandra 18g, Poria cocos 15g.
Embodiment 2
Compound Chinese herb Ultramicro-powder, is made up of the raw material of following weight: hawthorn 45g, Radix Codonopsis 20g, Radix Astragali 30g, Radix Angelicae Sinensis 23g, bark of eucommia 9g, rhizoma cyperi 9g, rheum officinale 7g, bighead atractylodes rhizome 19g, rhizoma atractylodis 23g, Stephania tetrandra 15g, Poria cocos 20g.
Embodiment 3
Compound Chinese herb Ultramicro-powder, is made up of the raw material of following weight: hawthorn 60g, Radix Codonopsis 18g, Radix Astragali 33g, Radix Angelicae Sinensis 20g, bark of eucommia 13g, rhizoma cyperi 7g, rheum officinale 10g, bighead atractylodes rhizome 17g, rhizoma atractylodis 31g, Stephania tetrandra 13g, Poria cocos 25g.
The preparation method of compound Chinese herb Ultramicro-powder in above-described embodiment, concrete preparation process is as follows: cleaned by above-mentioned raw materials after drying respectively, mix according to proportioning, first tentatively pulverize with pulverizer, carry out broken wall pulverizing with low temperature ultrasonic cracking pulverizer again, be ground into the superfines of less than 10 μm.
The application of the compound Chinese herb Ultramicro-powder of preparation, this compound Chinese herb Ultramicro-powder is for reducing the cholesterol level in egg.
Embodiment 4: zoopery
Chongren Chicken 90 plumage that 300 ages in days are healthy, body weight is close with laying rate is selected in 1 test, adopts single-factor completely randomized design, is divided into 2 groups, blank group, basal diet of feeding; Test group, the basis of basal diet is added 1% compound Chinese herb Ultramicro-powder.Often organize 3 repetitions, each repetition 15 plumage chicken.Trial test 7d, is just trying phase 60d.
2 test chicken basal diets need to prepare (table 1) with reference to NRC (1998) feeding standard laying hen nutrition.All test chickens adopt 3 layers of staged to raise in cages, and respectively repeat to be uniformly distributed in hen house.Before test, follow procedure carries out routine immunization and column home sterilization to chicken, raises one week chicken health and carries out formal test without illness side.Free choice feeding, drinking-water, every day, constant light was according to 16h.Duration of test clear excrement every day and receive each 2 times of egg.
3 duration of test time recording every day egg numbers, total egg size and feed intake.Often organize Stochastic choice 6 plumage in formal test the 1st day, 30 days, 60 days to cut open and kill, cut open and kill fore wing venous blood collection, blood is prepared serum after leaving standstill and is measured for Biochemical Indices In Serum.Kill the same day cuing open, randomly draw 12 pieces of eggs (4 pieces/repeat) from every group respectively, mark group, date, for measuring Egg cholesterol amount.
4 biochemical indicators and Egg cholesterol amount measure
Serum TG, TC, HDL-C (High-densitylipoproteincholesterol, HDL-C) and LDL-C (Low-densitylipoproteincholesterol, LDL-C) measure all in strict accordance with Nanjing build up bio-engineering corporation kit description operate.Egg cholesterol amount adopts sulphur ferrophosphorus reagent photometry to measure.
Table 1 Diet Formula and trophic level (air bells dry basis)
| Project | Content (%) |
| Raw material | |
| Corn | 64.20 |
| Dregs of beans | 21.00 |
| Stone flour | 8.10 |
| Calcium monohydrogen phosphate | 1.20 |
| Soybean oil | 4.00 |
| Salt | 0.31 |
| Premix | 1.00 |
| Lysine | 0.12 |
| DL-METHIONINE | 0.07 |
| Add up to | 100 |
| Trophic level | |
| Metabolizable energy/(MJ/kg) | 11.30 |
| Crude protein (%) | 17.20 |
| Calcium (%) | 3.43 |
| Total phosphorus (%) | 0.63 |
| Available phosphorus (%) | 0.45 |
| Lysine (%) | 0.92 |
| Methionine (%) | 0.38 |
Premix can be every kilogram of complete diet pellet and provides: VA8100IU; VD
31620IU; VE0.30IU; VK
30.90mg; VB
10.45mg; VB
22.70mg; VB
120.06g; Nicotinic acid 5.70mg; Folic acid 0.15mg; Biotin 0.045mg; Fe31.30mg; Cu4.59mg; Mn41.21mg, Zn42.04mg; I0.61mg; Se0.15mg; Choline 448.65mg; Chaff 3489.53mg; Metabolizable energy calculates gained according to raw material composition, and all the other are measured value.
5 data processings
All data are after Excel edit, and application SPSS17.0 statistical analysis software carries out single factor test variance (ANOVA) analysis, LSD method multiple comparison analyse, and the level of signifiance is P<0.05.Data average ± standard deviation
represent.
6 results and analysis
6.1 add compound Chinese herb Ultramicro-powder to the impact of Layer Production Performance
The change of performance in layers is in table 2.Whole duration of test, compares with control group, and the average daily laying rate of test group raises, significant difference (P<0.05); Average egg weight has downward trend, but difference is not significantly (P>0.05); And in experimental period feed intake without significant change (P>0.05).
Table 2 adds the impact of compound Chinese herb Ultramicro-powder on performance in layers
Note: in table, same line number value is marked with difference remarkable (P>0.05) in identical lowercase expression group, significant difference (P<0.05) in different lowercase expression group; Same columns value is marked with identical capitalization and represents group difference not significantly (P>0.05), and different capitalization represents that group difference significantly (P<0.05).Lower same.
6.2 add compound Chinese herb Ultramicro-powder to the impact of Laying-hen Serum biochemical indicator
Add compound Chinese herb Ultramicro-powder to the impact of Laying-hen Serum biochemical indicator in table 3.Compare in serum TG group, control group and test group are along with the increase of test number of days within experimental period, and all present downward trend after first rising, wherein 30d compares rising with 1d, 60d, significant difference (P<0.05); Compare between group, 30d, 60d test group compares decline with control group, significant difference (P<0.05).Compare in serum TC, LDL-C group, control group and test group all present ascendant trend, but test group difference is not significantly (P>0.05), and control group 30d compares rising with 1d, significant difference (P<0.05); Compare between serum TC group, test group compares decline with control group, 30d significant difference (P<0.05), and compares between serum LDL-C group, 60d significant difference (P<0.05).Compare in Serum HDL-C group, control group and test group along with the increase of test number of days, all present downward trend, and 30d compare decline with 1d, significant difference (P<0.05) within experimental period; Compare 60d test group between group and compare rising with control group, significant difference (P<0.05).
Table 3 adds the impact (mmol/L) of compound Chinese herb Ultramicro-powder on Laying-hen Serum biochemical indicator
6.3 add compound Chinese herb Ultramicro-powder to the impact of Egg cholesterol amount
Compound Chinese herb Ultramicro-powder on the impact of Egg cholesterol amount in table 4.Compare in group, the content difference of control group egg cholesterol within experimental period is not significantly (P>0.05), test group along with test number of days prolongation have downward trend, wherein 30d, 60d compare decline with 1d, significant difference (P<0.05); Compare between group, 30d, 60d test group compares decline with control group, significant difference (P<0.05).
Table 4 adds the impact (mg/ piece) of compound Chinese herb Ultramicro-powder on Egg cholesterol amount
7 discuss
This test adopts the long-pending Chinese herbal medicine composition compound Chinese herb Ultramicro-powder spending the function such as stagnant, promoting blood circulation and removing blood stasis that disappears, and utilizes adjusting blood lipid level to reduce Egg cholesterol amount.Result display test group serum TG, TC, LDL-C level significantly reduce, and HDL-C level significantly raises.Show that compound Chinese herb can reduce blood fat, possible cause is that all compounds are rich in reducing blood lipid Chinese herbal medicine.Liu Beilin etc. study discovery flavone of hawthorn fruit can reduce hyperlipidemia rats serum TG, TC, LDL-C level, raises HDL-C level.And rheum officinale, the bark of eucommia etc. all have blood fat reducing function.It is reported how much content of cholesterol depends primarily on VLDL content in liver in egg, and TG, TC content has relation in VLDL content and blood plasma, so plasma TG, TC content affect the cholesterol level in egg, simultaneously body endogenous cholesterol mainly to reverse from peripheral tissues with HDL-C form and transports liver back and excrete.So when serum TG, TC level reduce, when HDL-C level rises, egg cholesterol then significantly reduces thereupon.Experimental period, internal reference group blood fat presented ascendant trend, and reason may be that egg-laying peak laying hen body inner estrogen level is higher, and estrogen has the effect having and maintain egg-laying peak laying hen high fat of blood, and therefore serum TG levels rises.
The process of the mainly intracellular cholesteryl synthesis of cholesterol operation process in animal body, receptor-mediated cholesterol absorption and cholesterol esterification, arbitrary process is affected, and all may affect egg cholesterol deposition.Adding compound Chinese herb Ultramicro-powder can HDL-C level in increasing serum, and reduce LDL-C level, TC level in serum is declined, and Egg cholesterol amount also significantly declines thereupon.If but stop the biosynthesis of cholesterol completely, then can not maintain the required hormonal readiness of body, finally affect performance in layers.Therefore this test has the hawthorn, rheum officinale etc. of fat-reducing effect except using, and has also selected the Radix Astragali and the Radix Codonopsis of tonifying middle-Jiao and Qi, the Radix Angelicae Sinensis nourished blood, and the bark of eucommia of tonifying kidney and strengthening yang effect etc. increases the medicine of laying hen ovarian function.Result of the test shows, and after adding compound Chinese herb Ultramicro-powder, while Egg cholesterol amount reduces, laying rate of laying hen increases.
8 conclusions
This compound Chinese herb Ultramicro-powder is adopted to add in laying hen Basic drawing, facilitate the absorption of laying hen to diet nutrient and medicine, significantly can reduce the blood lipid level in laying hen, and significantly can reduce the cholesterol level in egg, the production performance that simultaneously laying hen can be kept higher.This compound Chinese herb Ultramicro-powder has good promotion prospect in low-cholesterol egg is produced.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
Claims (3)
1. a compound Chinese herb Ultramicro-powder, is characterized in that, is made up of the raw material of following weight portion: hawthorn 30 ~ 60 parts, Radix Codonopsis 18 ~ 22 parts, the Radix Astragali 26 ~ 33 parts, Radix Angelicae Sinensis 20 ~ 26 parts, the bark of eucommia 5 ~ 13 parts, rhizoma cyperi 7 ~ 11 parts, rheum officinale 4 ~ 10 parts, the bighead atractylodes rhizome 17 ~ 21 parts, rhizoma atractylodis 16 ~ 31 parts, Stephania tetrandra 13 ~ 18 parts, 15 ~ 25 parts, Poria cocos.
2. the preparation method of a compound Chinese herb Ultramicro-powder as claimed in claim 1 or 2, it is characterized in that, concrete preparation process is as follows: cleaned by above-mentioned raw materials after drying respectively, mix according to proportioning by science, first tentatively pulverize with pulverizer, carry out broken wall pulverizing with low temperature ultrasonic cracking pulverizer again, be ground into the superfines of less than 10 μm.
3. an application for the compound Chinese herb Ultramicro-powder prepared as claimed in claim 3, is characterized in that, this compound Chinese herb Ultramicro-powder can be used for reducing the cholesterol level in egg.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108420903A (en) * | 2018-05-02 | 2018-08-21 | 傅洪波 | Arhat gout dissipate and the preparation method and application thereof |
| CN108522872A (en) * | 2018-04-16 | 2018-09-14 | 佛山推启农业研究院（普通合伙） | A kind of pannage rich in various trace elements |
| CN109744189A (en) * | 2017-11-07 | 2019-05-14 | 天津硒艾格生物科技有限公司 | A kind of production method of low cholesterol homovitamin B6 egg |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102895569A (en) * | 2012-10-30 | 2013-01-30 | 天津生机集团股份有限公司 | Traditional Chinese medical oral solution for treatment of proventriculitis and ventriculitis of chicken and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109744189A (en) * | 2017-11-07 | 2019-05-14 | 天津硒艾格生物科技有限公司 | A kind of production method of low cholesterol homovitamin B6 egg |
| CN108522872A (en) * | 2018-04-16 | 2018-09-14 | 佛山推启农业研究院（普通合伙） | A kind of pannage rich in various trace elements |
| CN108420903A (en) * | 2018-05-02 | 2018-08-21 | 傅洪波 | Arhat gout dissipate and the preparation method and application thereof |
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Application publication date: 20160203 |
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