CN105267614A - Traditional Chinese medicine composition for preventing and treating uremia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing and treating uremia and preparation method thereof Download PDFInfo
- Publication number
- CN105267614A CN105267614A CN201510714824.XA CN201510714824A CN105267614A CN 105267614 A CN105267614 A CN 105267614A CN 201510714824 A CN201510714824 A CN 201510714824A CN 105267614 A CN105267614 A CN 105267614A
- Authority
- CN
- China
- Prior art keywords
- herba
- water
- parts
- radix
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating uremia. The traditional Chinese medicine composition is mainly prepared by, by weight, 9-13 parts of white peony root, 7-14 parts of gold stargrass herb, 6-12 parts of smallfruit fig aerial root, 8-13 parts of diversifolious pimpinella herb, 7-12 parts of shiny cinquefoil herb, 3-8 parts of epimedium, 6-10 parts of redfruit actionodaphne root, 10-14 parts of creeping oxalis, 7-13 parts of chloranthus spicatus, 9-14 parts of cornus officinalis, 5-9 parts of lily, 3-6 parts of Seville orange flower, 7-11 parts of prinsepia utilis royle and 8-12 parts of common aeschynomene herb. The traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition is evident, stable and reliable in curative effect, high in safety and wide in applicability, the traditional Chinese medicine composition completely conforms to the principles of traditional Chinese medicine and has effects such as warming the kidney and tonifying the spleen and promoting blood circulation to remove blood stasis, and the traditional Chinese medicine composition can be developed into various dosage forms and is wide in medicine sources, low in cost and low in economic burden of long-term use.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the uremic Chinese medicine composition of a kind of control and preparation method.
Background technology
Uremia is renal tissue almost whole fibrosis, causes the result that renal function is lost.And renal fibrosis is a kind of pathophysiological change, be kidney function by health to damage, then to damage, until the progressive process of afunction.Uremia is that nitrogenous metabolite and other toxicants can not be discharged and accumulate in vivo, except causing water, electrolyte and acid base imbalance, and can cause the pathological changes of multiple organ and system.Uremia's common sympton has that appetite disappears, insensitive, apathy, drowsiness, hypourocrinia, face and lower limbs edema, anemia, skin infections are itched, muscle spasm, sometimes can be toss about and feel uneasy, even occurs epilepsy.Symptoms of uremia can slowly occur, hidden for a long time and be not found.Acute renal failure can occur in several days, occurred obvious symptoms of uremia.Uremia syndrome can be diversified, and also not necessarily all symptoms all show.Uremia is to the very large a kind of disease of patient body injury, has a lot of reasons all can cause uremia, but wherein causes uremic arch-criminal to be exactly the chronic disease of kidney.Chronic renal failure Decompensated stage can adopt conservative treatment to delay disease progression.Absorption as increased chalybeate and folic acid is favourable improves renal anemia, can apply if desired erythropoietin, treatment hypertension, application calcium ion pick up the adsorbent such as anti-agent, oral Oxytarch, Oral Calcium Preparations and vitamin mouth treatment renal osteodystrophy.When renal function is irreversible, can consider to do dialysis treatment.Dialysis therapy comprises oral, peritoneum, hemodialysis (artificial kidney) three kinds.
Publication No. CN103690807A(application number 201310688110.7) Chinese patent literature disclose one and treat uremic Chinese medicine, have raw material Herba Epimedii 30g, Cortex Phellodendri 12g, Caulis Perillae 10g, Radix Clematidis 6g, Rhizoma Imperatae 20g, Fructus Psoraleae 15g, Radix Salviae Miltiorrhizae 15g, Rhizoma Alismatis 20g, Fructus Rubi 12g, Ramulus Uncariae Cum Uncis 9g, Herba Cistanches 15g, Semen Lepidii (Semen Descurainiae) 20g, Radix Ophiopogonis 10g, Herba Ecliptae 12g, Herba Plantaginis 10g, Indigo Naturalis 6g, Herba Ephedrae 10g, Fructus Lycii 10g, Radix Polygoni Multiflori 6g.Publication No. CN104173666A(application number 201410419681.5) Chinese patent literature disclose one and treat uremic medicine and preparation method, it is made up of Radix Et Rhizoma Rhei 250g, Semen Plantaginis 300g, RHIIZOMA DIOSCOREAE fr0m Henan of China 600g, Radix Cirsii Japonici 200g, Galla Chinensis 200g, Herba Lobeliae Chinensis 200g, Fructus Toosendan 100g, Folium Isatidis 300g, Ramulus Cinnamomi 100g, Fructus Psoraleae 300g, Radix Linderae 200g, Radix Panacis Quinquefolii 200g, Semen Pharbitidis 200g, Radix Polygalae 300g, Radix Rehmanniae 500g, Carapax Trionycis 250g, Flos Lonicerae 1000g, Rhizoma Coptidis 200g.Publication No. CN104189116A(application number 201410496449.1) Chinese patent literature disclose one and treat uremic Chinese medicine formula, crude drug quality proportioning is Poria 18-22 part, Cortex Moutan 8-12 part, Cortex Cinnamomi 22-28 part, Herba Dianthi 12-17 part.
Western medicine uremia, somewhat expensive, and can not effect a radical cure, also do not find optimal treatment method at present, Chinese medicine also has many for the research of this disease, and some curative effect is not obvious, can not reach the effect for the treatment of, therefore have needs to develop a kind of good effect, the traditional Chinese medical science formula that expense is low solves patient treatment difficulty.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide the uremic Chinese medicine composition of a kind of control evident in efficacy, taking convenience and preparation method.
Technical scheme of the present invention is:
The uremic Chinese medicine composition of a kind of control, is prepared from primarily of following bulk drugs, is mass parts: Radix Paeoniae Alba 9-13, Herba hypoxis aureae 7-14, Radix Aerio Fici Microcarpae 6-12, Herba pimpinellae diversifoliae 8-13, Herba potentillae fulgentis 7-12, Herba Epimedii 3-8, Radix Actinodaphnes Cupularis 6-10, Herba Oxalidis Corniculatae 10-14, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 7-13, Fructus Corni 9-14, Bulbus Lilii 5-9, Citrus aurantium L. var. amara Engl. 3-6, Folium Prinsepiae Utilis 7-11, Herba Aeschynonenes Indicae 8-12.
In preferred scheme, Radix Paeoniae Alba 10-12, Herba hypoxis aureae 9-12, Radix Aerio Fici Microcarpae 8-10, Herba pimpinellae diversifoliae 10-11, Herba potentillae fulgentis 8-11, Herba Epimedii 4-7, Radix Actinodaphnes Cupularis 7-9, Herba Oxalidis Corniculatae 11-13, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 9-11, Fructus Corni 10-13, Bulbus Lilii 6-8, Citrus aurantium L. var. amara Engl. 4-5, Folium Prinsepiae Utilis 8-10, Herba Aeschynonenes Indicae 9-11.
Be more preferably, the Radix Paeoniae Alba 11, Herba hypoxis aureae 10.5, Radix Aerio Fici Microcarpae 9, Herba pimpinellae diversifoliae 10.5, Herba potentillae fulgentis 9.5, Herba Epimedii 5.5, Radix Actinodaphnes Cupularis 8, Herba Oxalidis Corniculatae 12, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 10, Fructus Corni 11.5, Bulbus Lilii 7, Citrus aurantium L. var. amara Engl. 4.5, Folium Prinsepiae Utilis 9, Herba Aeschynonenes Indicae 10.
The preparation method of described Chinese medicine composition decoction, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, add decocting in water together with step (1) (2) made crude drug, big fire is boiled, and little fire decocts 24-40 minute, and (preferred, 28-36 minute decocted by little fire; Be more preferably, little fire decocts 32 minutes), filter, add water and boil again, merge twice filtrate;
(5) join in step (4) made filtrate by step (3) made clear paste, heated and stirred, mix homogeneously, filter, collect medicinal liquid, sterilizing, obtains decoction.
Described a kind of preparation method of preventing and treating uremic Chinese medicine composition decoction, the 6-8 that step (4) amount of water is boiled crude drug quality is (preferred, amount of water is 7 times of boiled crude drug quality) doubly.
The preparation method of described Chinese medicine composition soft extract, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, decocting in water is added together with step (1) (2) made crude drug, the 6-8 that amount of water is boiled crude drug quality is doubly (preferred, amount of water is 7 times of boiled crude drug quality), big fire is boiled, little fire decocts 24-40 minute, and (preferred, 28-36 minute decocted by little fire; Be more preferably, little fire decocts 32 minutes), filter, add water and boil again, merge twice filtrate, and be concentrated into 1/2 of original volume;
(5) join in step (4) made concentrated solution by step (3) made clear paste, heated and stirred, mix homogeneously, is brewed into clear paste, and sterilizing obtains soft extract.
Described a kind of preparation method of preventing and treating uremic Chinese medicine composition soft extract, the relative density of step (5) clear paste is 1.20-1.28(60 DEG C) (preferred, the relative density of clear paste is 1.22-1.26; Be more preferably, the relative density of clear paste is 1.24).
The preparation method of described Chinese medicine composition pill, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, pulverize and sieve together with step (1) (2) made crude drug and make medicated powder;
(5) step (3) made clear paste is joined in step (4) made medicated powder, mix thoroughly, add refined honey water, generally make ball, sterilizing, obtain pill.
Described a kind of preparation method of preventing and treating uremic Chinese medicine composition pill, step (4) was pulverized 120-200 mesh sieve and (preferably, was pulverized 140-180 mesh sieve; Be more preferably, pulverized 160 mesh sieves).
The preparation method of described Chinese medicinal composition capsules agent, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, decocting in water is added together with step (1) (2) made crude drug, the 6-8 that amount of water is boiled crude drug quality is (preferred, amount of water is 7 times of boiled crude drug quality) doubly, and big fire is boiled, 24-40 minute decocted by little fire, filter, add water and again decoct, merge twice filtrate, concentrate drying, pulverizes and makes medicated powder;
(5) step (3) made clear paste and step (4) made medicated powder are mixed, granule processed, sterilizing, incapsulates, and obtains capsule.
Described a kind of preparation method of preventing and treating uremic Chinese medicinal composition capsules agent, step (4) little fire is decocted 28-36 minute (preferred, little fire decocts 32 minutes).
The uremic Chinese medicine composition of one control provided by the invention obtains according to clinical empirical summary for many years, and compatibility rationally, is prepared easy, taken safety.In addition, excellent results of the present invention also shows:
1, the present invention is evident in efficacy and reliable and stable, and safety is high, and the suitability is wide;
2, this prescription meets Chinese medicine principle completely, has the effect such as warming the kidney and strengthening the spleen, blood circulation promoting and blood stasis dispelling;
3, the present invention can be developed into multiple dosage form, and medicine source is wide, and cost is low, and long-term taking economic pressures are little.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the uremic Chinese medicine composition of a kind of control, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Paeoniae Alba 9 parts, Herba hypoxis aureae 7 parts, Radix Aerio Fici Microcarpae 6 parts, Herba pimpinellae diversifoliae 8 parts, Herba potentillae fulgentis 7 parts, Herba Epimedii 3 parts, Radix Actinodaphnes Cupularis 6 parts, Herba Oxalidis Corniculatae 10 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 7 parts, Fructus Corni 9 parts, Bulbus Lilii 5 parts, Citrus aurantium L. var. amara Engl. 3 parts, Folium Prinsepiae Utilis 7 parts, Herba Aeschynonenes Indicae 8 parts.
Above-mentioned a kind of preparation method of preventing and treating uremic Chinese medicine composition decoction is:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, add decocting in water together with step (1) (2) made crude drug, amount of water is 7 times of boiled crude drug quality, and big fire is boiled, and little fire decocts 32 minutes, filters, adds water and boil, merge twice filtrate;
(5) join in step (4) made filtrate by step (3) made clear paste, heated and stirred, mix homogeneously, filter, collect medicinal liquid, sterilizing, obtains decoction.
embodiment 2the uremic Chinese medicine composition of a kind of control, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Paeoniae Alba 13 parts, Herba hypoxis aureae 14 parts, Radix Aerio Fici Microcarpae 12 parts, Herba pimpinellae diversifoliae 13 parts, Herba potentillae fulgentis 12 parts, Herba Epimedii 8 parts, Radix Actinodaphnes Cupularis 10 parts, Herba Oxalidis Corniculatae 14 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 13 parts, Fructus Corni 14 parts, Bulbus Lilii 9 parts, Citrus aurantium L. var. amara Engl. 6 parts, Folium Prinsepiae Utilis 11 parts, Herba Aeschynonenes Indicae 12 parts.
A kind of preparation method of preventing and treating uremic Chinese medicine composition soft extract is:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, add decocting in water together with step (1) (2) made crude drug, amount of water is 7 times of boiled crude drug quality, big fire is boiled, and little fire decocts 32 minutes, filters, add water and boil again, merge twice filtrate, and be concentrated into 1/2 of original volume;
(5) join in step (4) made concentrated solution by step (3) made clear paste, heated and stirred, mix homogeneously, being brewed into relative density is 1.24(60 DEG C) clear paste, sterilizing, obtains soft extract.
Model case: xxx, female, 56 years old.Main suit: the year before, because the acid of self-induction waist is swollen, extremity edema, shallow complexion, hospital gives treatment to, and is diagnosed as uremia, rear hospitalization, and symptom is improved, go home to recuperate, nearly two months aggravations, emaciated physique, bitter taste, edema of lower limbs is obvious, and with skin pruritus, institute of traditional Chinese medicine checks, tongue is dark red, yellow and greasy fur, wiry and frequent pulse, urine protein (+++), leukocyte (++), creatinine 812 μm of ol/L, blood urea nitrogen 26.1mmol/L, is diagnosed as uremia again.
Patient accepts hemodialysis treatment and takes the uremic Chinese medicine composition soft extract of the present embodiment gained one control, every day 2 times, each 5-10ml, warm boiled water, 20 days courses for the treatment of simultaneously.After taking two weeks, edema of lower limbs obviously disappears, and skin pruritus is eliminated, and waist acid is swollen to alleviate, and after taking a course for the treatment of, all diseases of patient are eliminated substantially, reduces hemodialysis number of times, and after adhering to taking two courses for the treatment of, urine protein (-), renal function indices is all close to normal.Patient body is followed up a case by regular visits in good condition after 1 year.
embodiment 3the uremic Chinese medicine composition of a kind of control, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Paeoniae Alba 10 parts, Herba hypoxis aureae 9 parts, Radix Aerio Fici Microcarpae 8 parts, Herba pimpinellae diversifoliae 10 parts, Herba potentillae fulgentis 8 parts, Herba Epimedii 4 parts, Radix Actinodaphnes Cupularis 7 parts, Herba Oxalidis Corniculatae 11 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 9 parts, Fructus Corni 10 parts, Bulbus Lilii 6 parts, Citrus aurantium L. var. amara Engl. 4 parts, Folium Prinsepiae Utilis 8 parts, Herba Aeschynonenes Indicae 9 parts.
A kind of preparation method of preventing and treating uremic Chinese medicine composition pill is:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, pulverized 160 mesh sieves and make medicated powder together with step (1) (2) made crude drug;
(5) step (3) made clear paste is joined in step (4) made medicated powder, mix thoroughly, add refined honey water, generally make ball, sterilizing, obtain pill.
Model case: xxx, man, 57 years old.Main suit: started to occur uncomfortable in chest weak before half a year, nearly two weeks lower limb and face's edema obvious, complexion is dull, mouth Zhou Fazi, examination in hospital, conscious, tired mind, kidney function test, creatinine 886.2 μm of mol/L, blood urea nitrogen 36.2mmol/L, hemoglobin 76g/L, medical history: suffer from hypertension 5 years, be diagnosed as hypertension uremia.
Patient accepts hemodialysis treatment and takes the uremic Chinese medicine composition pill of the present embodiment gained one control simultaneously, adopts every day 2 times, each 4, with warm water delivery service, and 20 days courses for the treatment of.After taking one week, patient is uncomfortable in chest to alleviate, and edema fades and moves back, after taking a course for the treatment of, edema disappears substantially, reduces hemodialysis number of times, continue to take two courses for the treatment of, blood pressure remains stable, creatinine 343.7 μm of mol/L, blood urea nitrogen 16.7mmol/L, hemoglobin 85g/L, adhere to taking half a year, renal function indices is without larger fluctuation, follow up a case by regular visits to after 1 year, patient can orthobiosis, stable disease.
embodiment 4the uremic Chinese medicine composition of a kind of control, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Paeoniae Alba 12 parts, Herba hypoxis aureae 12 parts, Radix Aerio Fici Microcarpae 10 parts, Herba pimpinellae diversifoliae 11 parts, Herba potentillae fulgentis 11 parts, Herba Epimedii 7 parts, Radix Actinodaphnes Cupularis 9 parts, Herba Oxalidis Corniculatae 13 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 11 parts, Fructus Corni 13 parts, Bulbus Lilii 8 parts, Citrus aurantium L. var. amara Engl. 5 parts, Folium Prinsepiae Utilis 10 parts, Herba Aeschynonenes Indicae 11 parts.
A kind of preparation method of preventing and treating uremic Chinese medicinal composition capsules agent is:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, decocting in water is added together with step (1) (2) made crude drug, amount of water is 7 times of boiled crude drug quality, big fire is boiled, and little fire decocts 32 minutes, filters, add water and again decoct, merge twice filtrate, concentrate drying, pulverize and make medicated powder;
(5) step (3) made clear paste and step (4) made medicated powder are mixed, granule processed, sterilizing, incapsulates, and obtains capsule.
Model case: xxx, man, 60 years old.Main suit: hydrosarca, fever with aversion to cold two weeks, with cough with asthma, soreness of the waist and knees, dysuria, hypourocrinia, abdominal distention poor appetite, stool is not smooth, examination in hospital, dim complexion, light red tongue, and tongue is white, floating and tense pulse, creatinine 786.2 μm of mol/L, blood urea nitrogen 24.8mmol/L, urine protein (++), is diagnosed as uremia.
Patient takes a routine treatment and takes the uremic Chinese medicinal composition capsules agent of the present embodiment gained one control simultaneously, adopts every day 2 times, each 4, with warm water delivery service, and 20 days courses for the treatment of.After taking two weeks, patient's eyelid and two lower limbs edema obviously disappear, free movement of the bowels, after taking a course for the treatment of, aversion to cold symptom is eliminated, and appetite increases, after taking two courses for the treatment of, all diseases of patient are eliminated substantially, only have slightly weak, after continuing to take a course for the treatment of, patient mental is good, without suitable symptom, creatinine, blood urea nitrogen are all within normal range, urine protein (-), patient cures, and follows up a case by regular visits to stable disease after 1 year.
embodiment 5the uremic Chinese medicine composition of a kind of control, is prepared from (every part of 10g) primarily of following bulk drugs: the Radix Paeoniae Alba 11 parts, Herba hypoxis aureae 10.5 parts, Radix Aerio Fici Microcarpae 9 parts, Herba pimpinellae diversifoliae 10.5 parts, Herba potentillae fulgentis 9.5 parts, Herba Epimedii 5.5 parts, Radix Actinodaphnes Cupularis 8 parts, Herba Oxalidis Corniculatae 12 parts, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 10 parts, Fructus Corni 11.5 parts, Bulbus Lilii 7 parts, Citrus aurantium L. var. amara Engl. 4.5 parts, Folium Prinsepiae Utilis 9 parts, Herba Aeschynonenes Indicae 10 parts.
A kind of preparation method of preventing and treating uremic Chinese medicine composition decoction is:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, add decocting in water together with step (1) (2) made crude drug, amount of water is 7 times of boiled crude drug quality, and big fire is boiled, and little fire decocts 32 minutes, filters, adds water and boil, merge twice filtrate;
(5) join in step (4) made filtrate by step (3) made clear paste, heated and stirred, mix homogeneously, filter, collect medicinal liquid, sterilizing, obtains decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Paeoniae Alba: base is former: be the root of ranunculaceae plant Radix Paeoniae.Nature and flavor: bitter, sour, are slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Herba hypoxis aureae: base is former: be the Herb of amrallid Herba hypoxis aureae.Nature and flavor: sweet, micro-pungent, warm.Function cures mainly: warming the kidney to invigorate YANG, regulating QI to relieve pain.Main lumbago due to renal deficiency, sexual impotence, insomnia, colic of cold type is suffered from abdominal pain.
Radix Aerio Fici Microcarpae: base is former: be the aerial root of moraceae plants Ficus microcarpa Linn. f.Nature and flavor: pained are flat.Function cures mainly: expelling wind and clearing away heat, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease is suffered from abdominal pain, rheumatic ostalgia, epistaxis, stranguria with blood, traumatic injury.
Herba pimpinellae diversifoliae: base is former: be the herb of the different leaf Pimpinella anisum Linn. of samphire.Nature and flavor: pungent, micro-hardship, temperature.Function cures mainly: expelling wind and activating blood circulation, removing toxic substances and promoting subsidence of swelling.For flu, laryngopharynx swelling and pain, dysentery, icterohepatitis, venom is controlled in external, traumatic injury, skin itching.
Herba potentillae fulgentis: base is former: be root or the whole herb with root of rosaceous plant Herba potentillae fulgentis.Nature and flavor: cold, pained.Function cures mainly: heat clearing and inflammation relieving, cooling blood for hemostasis.Control dysentery, enteritis, stomachache, hemoptysis of pulmonary tuberculosis, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, furuncle.
Herba Epimedii: base is former: be the stem and leaf of Berberidaceae plant Herba Epimedii, Epimedium brevicornum or Epimedium sagittatum.Nature and flavor: acrid, sweet, warm.Gui Jing: return liver, kidney channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture, climacteric hypertension.
Radix Actinodaphnes Cupularis: base is former: be root, the leaf of the yellow meat nanmu of canella Fructus Pyracanthae.Nature and flavor: pungent are cool.Function cures mainly: removing toxic substances, antiinflammatory.Cure mainly burn and scald, tinea pedis, hemorrhoid.
Herba Oxalidis Corniculatae: base is former: be the oxalic herb of Oxalidaceae plant.Nature and flavor: acid are cool.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For cold, fever, enteritis, urinary tract infection, lithangiuria, neurasthenia, traumatic injury is controlled in external, venom, carbuncle furuncle, tinea pedis, eczema, burn and scald.
Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.): base is former: be the stem and leaf of Chloranthaceae plant chu lan tree.Nature and flavor: pungent, sweet, micro-puckery, temperature.Function cures mainly: wind-damp dispelling, connects muscles and bones.For flu, rheumatic arthritis, traumatic injury.
Fructus Corni: base is former: be the sarcocarp of Cornaceae plant Fructus Corni.Nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: liver and kidney tonifying, essence astringing and desertion stemming.For vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating is collapsed.Interior-heat is quenched one's thirst.
Bulbus Lilii: base is former: be liliaceous plant Bulbus Lilii, Lilium tenuifolium, Lilium longiflorum and the scale leaf belonging to various plants bulb together thereof.Nature and flavor: sweet, cold.Gui Jing: GUIXIN, lung meridian.Function cures mainly: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Citrus aurantium L. var. amara Engl.: base is former: be the alabastrum of Folium Symplocoris Caudatae profit plant Citrus aurantium L. var. amara Engl..Nature and flavor: sweet micro-hardship.Function cures mainly: soothing the liver, and stomach function regulating is regulated the flow of vital energy.Control painful abdominal mass in the heart vexed, abdominal distention, vomiting, few food.
Folium Prinsepiae Utilis: base is former: be the leaf of rosaceous plant Folium Prinsepiae Utilis.Nature and flavor: bitter, pungent, cool.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.For lymphadenitis, parotitis, mastitis, rheumatic arthritis, hemorrhoid, traumatic injury, menoxenia, anemia, gingival hemorrhage.
Herba Aeschynonenes Indicae: base is former: be the herb of bean kind of plant Herba Aeschynonenes Indicae.Nature and flavor: sweet light, cold.Function cures mainly: heat clearing away, removes wind, dampness removing, detumescence, removing toxic substances.Control anemopyretic cold, jaundice, dysentery, gastritis, abdominal distention, gonorrhea, carbuncle, dermatitis, eczema.
test example 1the clinical practice of the gained one uremic Chinese medicine composition of control (embodiment 5) of the present invention:
In February ,-2014 in June, 2011, filter out in the uremic patient that 4 hospitals accept for medical treatment 224 example, wherein man 122 example, female 102 example, age 28-62 year, the mean age (42.5 ± 4.6) year, course of disease 1.2-3.1, average course of disease (1.9 ± 0.6) year.All patients all meet doctor trained in Western medicine chronic renal insufficiency Uremic, serum creatinine (Scr) >=707.2 μm mol/L, endogenous creatinine clearance rate (Ccr) <10ml/min, and can maintenance rule hemodialysis.
Patient is divided into two groups at random, experimental group 124 example and matched group 100 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference (P > 0.05), there is comparability.Matched group adopts conventional dialysis procedures, experimental group takes products obtained therefrom of the present invention on dialysis basis, take every day twice (warm), each 350m1-500m1(adjusts to some extent depending on concrete condition), 20 days courses for the treatment of, treatments period carries out Continuous Observation to two groups of patients, the situation of change of symptom and creatinine (Scr), blood urea nitrogen (Bun), hemoglobin (Hb), total protein (TP) before and after record treatment.
Curative effect situation criterion: effective: clinical symptoms disappears substantially, each biochemical indicator returns to normal level substantially; Effective: clinical symptoms and biochemical indicator obviously improve, creatinine and blood urea nitrogen decline 30% ~ 50%; Invalid: clinical symptoms and biochemical indicator all do not improve or improve not obvious.Total effective rate=(effective+effectively)/total number of cases × 100%
Table 1 liang group patient treatment outcome
Two groups of therapeutic outcomes are as shown in table 1, effective 53 examples of experimental group, and effective 65 examples, invalid 6 examples, treatment total effective rate is 95.2%.Effective 32 examples of matched group, effective 47 examples, invalid 21 examples, treatment total effective rate is 79.0%, two groups and compares, and the therapeutic effect of matched group is starkly lower than experimental group.
Before and after two groups of patient treatments, the change of biochemical indicator is more as shown in table 2.
Before and after table 2 liang group patient treatment, the change of biochemical indicator is compared
As shown in Table 2, after two groups of patient treatments, Bun and Scr obviously reduces (P < 0.01) before all comparatively treating, and between latter two groups for the treatment of, comparing difference significantly (P < 0.05).Compared with before treatment, after experimental group treatment, Hb and TP all significantly increases (P < 0.05), and matched group Hb and TP increases not obvious (P > 0.05), Hb and TP significant difference (P < 0.05) between two groups after treatment.Two groups for the treatment of situations are compared, and illustrate that hemodialysis coordinates that to take the more simple hemodialysis of products made thereby of the present invention effective simultaneously, can alleviate renal fibrosis, improve renal function.
In formula of the present invention, the Radix Paeoniae Alba can suppressing the hyperactive liver pain relieving, and Herba hypoxis aureae can warming the kidney to invigorate YANG, and Radix Aerio Fici Microcarpae can promoting blood circulation and detoxication, Herba pimpinellae diversifoliae can expelling wind and activating blood circulation, and Herba potentillae fulgentis can heat clearing and inflammation relieving, and Herba Epimedii can kidney-replenishing, Radix Actinodaphnes Cupularis can detoxicating, relieving inflammation, and Herba Oxalidis Corniculatae can clearing away heat-damp and promoting diuresis, and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) can wind-damp dispelling, Fructus Corni can liver and kidney tonifying, and Bulbus Lilii can nourishing YIN and moistening the lung, and Citrus aurantium L. var. amara Engl. can depressed liver-energy dispersing and QI regulating, Folium Prinsepiae Utilis can promoting blood circulation and detumescence, Herba Aeschynonenes Indicae can be inducing diuresis and reducing edema, and all medicines share, and plays the effect such as warming the kidney and strengthening the spleen, blood circulation promoting and blood stasis dispelling altogether.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. prevent and treat a uremic Chinese medicine composition, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Paeoniae Alba 9-13, Herba hypoxis aureae 7-14, Radix Aerio Fici Microcarpae 6-12, Herba pimpinellae diversifoliae 8-13, Herba potentillae fulgentis 7-12, Herba Epimedii 3-8, Radix Actinodaphnes Cupularis 6-10, Herba Oxalidis Corniculatae 10-14, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 7-13, Fructus Corni 9-14, Bulbus Lilii 5-9, Citrus aurantium L. var. amara Engl. 3-6, Folium Prinsepiae Utilis 7-11, Herba Aeschynonenes Indicae 8-12.
2. the uremic Chinese medicine composition of a kind of control as claimed in claim 1, it is characterized in that, Radix Paeoniae Alba 10-12, Herba hypoxis aureae 9-12, Radix Aerio Fici Microcarpae 8-10, Herba pimpinellae diversifoliae 10-11, Herba potentillae fulgentis 8-11, Herba Epimedii 4-7, Radix Actinodaphnes Cupularis 7-9, Herba Oxalidis Corniculatae 11-13, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 9-11, Fructus Corni 10-13, Bulbus Lilii 6-8, Citrus aurantium L. var. amara Engl. 4-5, Folium Prinsepiae Utilis 8-10, Herba Aeschynonenes Indicae 9-11 is (preferred, the Radix Paeoniae Alba 11, Herba hypoxis aureae 10.5, Radix Aerio Fici Microcarpae 9, Herba pimpinellae diversifoliae 10.5, Herba potentillae fulgentis 9.5, Herba Epimedii 5.5, Radix Actinodaphnes Cupularis 8, Herba Oxalidis Corniculatae 12, Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.) 10, Fructus Corni 11.5, Bulbus Lilii 7, Citrus aurantium L. var. amara Engl. 4.5, Folium Prinsepiae Utilis 9, Herba Aeschynonenes Indicae 10).
3. the preparation method of the Chinese medicine composition decoction as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, add decocting in water together with step (1) (2) made crude drug, big fire is boiled, and little fire decocts 24-40 minute, and (preferred, 28-36 minute decocted by little fire; Be more preferably, little fire decocts 32 minutes), filter, add water and boil again, merge twice filtrate;
(5) join in step (4) made filtrate by step (3) made clear paste, heated and stirred, mix homogeneously, filter, collect medicinal liquid, sterilizing, obtains decoction.
4. a kind of preparation method of preventing and treating uremic Chinese medicine composition decoction as claimed in claim 3, is characterized in that, the 6-8 that step (4) amount of water is boiled crude drug quality is (preferred, amount of water is 7 times of boiled crude drug quality) doubly.
5. the preparation method of the Chinese medicine composition soft extract as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, decocting in water is added together with step (1) (2) made crude drug, the 6-8 that amount of water is boiled crude drug quality is doubly (preferred, amount of water is 7 times of boiled crude drug quality), big fire is boiled, little fire decocts 24-40 minute, and (preferred, 28-36 minute decocted by little fire; Be more preferably, little fire decocts 32 minutes), filter, add water and boil again, merge twice filtrate, and be concentrated into 1/2 of original volume;
(5) join in step (4) made concentrated solution by step (3) made clear paste, heated and stirred, mix homogeneously, is brewed into clear paste, and sterilizing obtains soft extract.
6. a kind of preparation method of preventing and treating uremic Chinese medicine composition soft extract as claimed in claim 5, is characterized in that, the relative density of step (5) clear paste is that 1.20-1.28(is preferred, and the relative density of clear paste is 1.22-1.26; Be more preferably, the relative density of clear paste is 1.24).
7. the preparation method of the Chinese medicine composition pill as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, pulverize and sieve together with step (1) (2) made crude drug and make medicated powder;
(5) step (3) made clear paste is joined in step (4) made medicated powder, mix thoroughly, add refined honey water, generally make ball, sterilizing, obtain pill.
8. a kind of preparation method of preventing and treating uremic Chinese medicine composition pill as claimed in claim 7, is characterized in that, step (4) was pulverized 120-200 mesh sieve and (preferably, pulverized 140-180 mesh sieve; Be more preferably, pulverized 160 mesh sieves).
9. the preparation method of the Chinese medicinal composition capsules agent as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Radix Aerio Fici Microcarpae salt water infiltration 15 minutes, take out section and mixes thoroughly with rice vinegar together with Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), moistening exhausts to vinegar, takes out Radix Aerio Fici Microcarpae sheet and Caulis seu folium chloranthi spicati (Chloranthus spicatus(Thunb.) Mak.), then adds yellow wine mix thoroughly together with Fructus Corni, and load and steam in cup, Steam by water bath to Fructus Corni be pitchy, takes out, oven dry;
(2) by Herba hypoxis aureae, Herba pimpinellae diversifoliae, Herba Epimedii and Folium Prinsepiae Utilis roguing, with mature vinegar and water retting, slow fire heating is boiled and is exhausted to water, and take out, be placed in frying pan and spill Sanguis Gallus domesticus and mix thoroughly, slow fire heats, and fries to dry tack free, takes out, dries in the air cool;
(3) scalded 5 minutes by Bulbus Lilii boiling water, take out, get Citrus aurantium L. var. amara Engl. slow fire and fry to buff taking-up, made Bulbus Lilii is pulverized together with Citrus aurantium L. var. amara Engl., is boiled into clear paste with hydromel, stand-by;
(4) Radix Paeoniae Alba, Herba potentillae fulgentis, Radix Actinodaphnes Cupularis, Herba Oxalidis Corniculatae and Herba Aeschynonenes Indicae are cleaned, decocting in water is added together with step (1) (2) made crude drug, the 6-8 that amount of water is boiled crude drug quality is (preferred, amount of water is 7 times of boiled crude drug quality) doubly, and big fire is boiled, 24-40 minute decocted by little fire, filter, add water and again decoct, merge twice filtrate, concentrate drying, pulverizes and makes medicated powder;
(5) step (3) made clear paste and step (4) made medicated powder are mixed, granule processed, sterilizing, incapsulates, and obtains capsule.
10. a kind of preparation method of preventing and treating uremic Chinese medicinal composition capsules agent as claimed in claim 9, is characterized in that, step (4) little fire is decocted 28-36 minute (preferred, little fire decocts 32 minutes).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510714824.XA CN105267614A (en) | 2015-10-29 | 2015-10-29 | Traditional Chinese medicine composition for preventing and treating uremia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510714824.XA CN105267614A (en) | 2015-10-29 | 2015-10-29 | Traditional Chinese medicine composition for preventing and treating uremia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105267614A true CN105267614A (en) | 2016-01-27 |
Family
ID=55138004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510714824.XA Withdrawn CN105267614A (en) | 2015-10-29 | 2015-10-29 | Traditional Chinese medicine composition for preventing and treating uremia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105267614A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314182A (en) * | 2001-03-07 | 2001-09-26 | 孙振启 | Pill for moistening kidney and replenishing marrow |
| CN101085130A (en) * | 2007-07-19 | 2007-12-12 | 丽珠医药集团股份有限公司 | Medicinal composition for treating acute renal failure |
| CN101085128A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine for treating chronic renal failure |
-
2015
- 2015-10-29 CN CN201510714824.XA patent/CN105267614A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1314182A (en) * | 2001-03-07 | 2001-09-26 | 孙振启 | Pill for moistening kidney and replenishing marrow |
| CN101085128A (en) * | 2007-06-26 | 2007-12-12 | 北京艺信堂医药研究所 | Traditional Chinese medicine for treating chronic renal failure |
| CN101085130A (en) * | 2007-07-19 | 2007-12-12 | 丽珠医药集团股份有限公司 | Medicinal composition for treating acute renal failure |
Non-Patent Citations (2)
| Title |
|---|
| 杨德山: "中药治疗尿毒症的体会", 《天津中医药》 * |
| 颜德馨等主编: "《中华养生大全》", 31 December 2001 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104784673B (en) | A kind of Chinese traditional medicine navel for infantile diarrhea pastes | |
| CN104383088A (en) | Traditional Chinese medicine composition for treating postpartum abdominal pain | |
| CN104800504A (en) | Traditional Chinese medicine preparation for treating nephritis and preparation method | |
| CN103845580A (en) | Traditional Chinese medicine composition for treating allergic rhinitis | |
| CN106491971A (en) | A kind of for treating Chinese medicine composition of pulpitiss and preparation method thereof | |
| CN104771585A (en) | Traditional Chinese medicine composition for treating acute nephritis and preparation method thereof | |
| CN104274812A (en) | Traditional Chinese medicine for treatment of gastropathy | |
| CN104367827A (en) | Traditional Chinese medicine for treating spleen-qi deficiency-weakness syndrome type somnolence | |
| CN104707009B (en) | A kind of Chinese medicine for the treatment of type of blood-stasis obstructing in the interior anaphylactoid purpura | |
| CN103656199B (en) | A kind of Chinese medicine for the treatment of deficiency of kidney yin syndrome cough | |
| CN102552772B (en) | Traditional Chinese medicine used for treating chronic cough lung deficiency | |
| CN101869629B (en) | Traditional Chinese medicine for treating renal calculus | |
| CN103432422B (en) | Traditional Chinese medicine for treating chronic gastritis | |
| CN105267614A (en) | Traditional Chinese medicine composition for preventing and treating uremia and preparation method thereof | |
| CN106110152A (en) | A kind of damp eliminating fat is regulated the flow of vital energy granule | |
| CN105770354A (en) | Medicament for treating chronic nephritis and preparation method thereof | |
| CN104771558A (en) | Traditional Chinese medicine composition for treating nephritis and preparation method of traditional Chinese medicine composition | |
| CN104758888A (en) | Traditional Chinese medicine composition for treating diabetes | |
| CN104474452A (en) | Medicine for treating blood coagulation and toxin accumulating bedsore and preparation method of medicine | |
| CN104547446B (en) | A kind of Chinese medicine for the treatment of qi-deficiency type abdominal postoperative urine retention | |
| CN104258125A (en) | Traditional Chinese medicine pills for treating postpartum anemia | |
| CN103933529A (en) | Traditional Chinese medicine preparation for treating cardialgia caused by deficiency of heart-qi | |
| CN105560561A (en) | Traditional Chinese medicine for treating aconuresis | |
| CN102284026B (en) | Chinese medicine for treating hematuria | |
| CN102228641B (en) | Chinese medicine for treating acquired immune deficiency syndrome and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: 352000 children's Palace Road, Jiaocheng District, Fujian, Ningde, No. Applicant after: Zhang Xiangcai Address before: 250000 Hualong Road, Licheng District, Shandong, China, No. 16, No. Applicant before: Zhang Xiangcai |
|
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160127 |