CN105267184B - A kind of anti-inflammatory analgetic cataplasm and preparation method thereof - Google Patents
A kind of anti-inflammatory analgetic cataplasm and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of cataplasms of anti-inflammatory analgetic and preparation method thereof.Ointment in the cataplasm contains following substance：Flos Carthami extract, Radix Notoginseng extracting solution and own root extracting solution, Paeonol, Sodium Polyacrylate, ice crystal forming agent AVC, hydroxyethyl cellulose, Carbopol 941, cation guar gum, menthol, ethylparaben alcoholic solution, distilled water, glycerine, ethyl alcohol.Compared with prior art, the present invention have the characteristics that transdermal effect is good, dose ingredient is controllable and be sustained, good permeability, to skin biological compatibility good, sweat proof, to repeat to take off patch property good, non-stimulated, the pain symptom of neck-shoulder pain, lumbago and leg pain can be effectively relieved.
Description
Technical field
It is the present invention relates to a kind of cataplasm of anti-inflammatory analgetic, more particularly to a kind of with anti-inflammatory and neck-shoulder pain, lumbago and leg pain to be alleviated
Cataplasm and preparation method thereof belongs to art of pharmacy.
Background technology
Inflammation is exactly " inflammation " usually described in people, is a kind of defense reaction of the body for stimulation, show as it is red,
Swollen, heat, pain.Inflammation can be infective inflammation caused by infection, may not be the non-infectious inflammation caused by infection
Disease.Under normal conditions, inflammation is beneficial, is the automatic defense reaction of human body, but sometimes, inflammation is also harmful
, for example, to the attack of human body autologous tissue, be happened at the inflammation etc. of hyaline tissue.
Cataplasm have many advantages, such as dosage is accurate, absorption area is small, blood concentration is stable, using comfort and convenient.Its
Transdermal effect is good, dose ingredient is controllable and be sustained, good permeability, it is good to skin biological compatibility, repeat to take off the features such as patch property is good,
It is ideal external used medicine transmission platform.It is free of the toxicants such as yellow lead specific to traditional plaster, not will produce lead poisoning
Equal adverse reactions, and it will not be stained clothing, especially suitable for all kinds of Chinese medical concrete preparations.
Compared with oral medicine, without alimentary canal, is not influenced by food, gastric juice and destruction, no first pass effect are raw
Object availability is high, avoids usually oral medication to the stimulation and damage caused by gastrointestinal mucosa and liver.Relatively it is suitable for those
The patient that should not be administered orally due to various reasons substantially increases the compliance of patient, avoids and misses, repeats to take to be produced
Raw state of an illness fluctuation, drug risk caused by effectively avoiding accidentally.
The factors such as water content, bioavilability, comfort and the gas permeability of the pairs of Babu plaster of group of matrix play leading make
With.The composition of matrix and proportioning are adjusted as drug is different, make the existing good adhesion of cataplasm, and are had preferable
Ductility, moisture retention and certain intensity.
If can be combined with this novel form of cataplasm, anti-inflammatory with there is the Chinese medicine of definite anti-inflammatory analgetic curative effect to carry out prescription
Preferable effect will be played in terms of analgesic.
Invention content
First technical problem to be solved by this invention be to provide it is a kind of it is new can containing natural traditional Chinese medicine component extract
With the cataplasm of anti-inflammatory analgetic.
Second technical problem to be solved by this invention is to provide the preparation method of above-mentioned cataplasm.
A kind of cataplasm of anti-inflammatory analgetic of the present invention, the raw material containing following dosage proportioning in ointment：
In anti-inflammatory analgetic cataplasm described above, the saffron aqueous solution is prepared by the following method to obtain：
It takes safflower appropriate, 10-18 times of distilled water is added, extract 1-2h with reflux extraction, collect extracting solution, add
10-15 times of distilled water extracts 1-2h with reflux extraction, collects extracting solution, then add 8-12 times of distilled water, carried with reflux
It follows the example of extraction 0.5-1h, filters every time, filtrate will merge three times, filtrate is concentrated into 1-3 times of safflower weight, filters to obtain the final product.
In anti-inflammatory analgetic cataplasm described above, the Radix Notoginseng alcohol extract is prepared by the following method to obtain：
It takes Radix Notoginseng appropriate, is ground into coarse powder, extracted 3 times with circumfluence method, 10-15 times of 60%-85% ethyl alcohol is added for the first time,
15-55min is impregnated, 1-2h is extracted, collects extracting solution, 9-15 times of 60%-85% ethyl alcohol of second of addition extracts 1-2h, and collection carries
It takes liquid, third time that 8-12 times of 60%-85% ethyl alcohol is added and extracts 0.5-1.5h, filters every time, filtrate will merge three times, filtrate is dense
It is reduced to 1-3 times of three seven weights, filters to obtain the final product.Wherein, 60%-85% ethyl alcohol refers to volume fraction, extractant used when extraction
It is preferred that 75% ethyl alcohol.
In anti-inflammatory analgetic cataplasm described above, described and own root Aqueous extracts are prepared by the following method to obtain：
It taking and own root is appropriate, be ground into coarse powder, 10-15 times of distilled water is added in refluxing extraction 3 times for the first time, extracts 1-2h,
Extracting solution is collected, adds 9-14 times of distilled water for the second time, refluxing extraction 1-2h collects extracting solution, and third time is added 7-10 times
Distilled water extracts 0.5-1.5h, filters every time, filtrate will merge three times, and filtrate is concentrated into and 1-3 times of own root weight, filters
To obtain the final product.
Saffron aqueous solution described above, Radix Notoginseng alcohol extract, own root Aqueous extracts preparation process in, the extractant that is added every time
If the dosage of water or alcohol is the multiple of weighed materials stock weight.70%-85% ethyl alcohol of the present invention is for volume
Ice crystal forming agent AVC may be selected in score, ice crystal forming agent of the present invention, and Carbopol 941 may be selected in the carbomer, described
0.1%-0.5% ethylparaben alcoholic solutions are for weight fraction, and the ethyl alcohol of preferable 0.2% ethylparaben is molten in the present invention
Liquid.
The preparation method of anti-inflammatory analgetic cataplasm of the present invention, includes the following steps：
A) saffron aqueous solution 2-5ml, Radix Notoginseng alcohol extract 2-5ml and own root Aqueous extracts 2-5ml are measured and are sufficiently stirred mixing,
It is for use as solution A；
B) 5-30ml glycerine is measured, 0.05-0.15g Sodium Polyacrylates is weighed and is scattered in glycerine, 40-80ml distillations are added
Water stirs evenly, and stands 2-4 hours and waits for that it is swollen dissolving naturally, swelling is complete, and it is for use to form solution B；
C) ice crystal forming agent 0.05-0.15g is weighed, is scattered in 5-50ml distilled water, fully swelling dissolving, swelling
Completely, it is for use to form solution C；
D) hydroxyethyl cellulose 0.05-0.15g is weighed, is scattered in 5-20ml distilled water, fully swelling dissolving is molten
It is swollen complete, it is for use to form solution D；
E) carbomer 0.05-0.15g is weighed, is scattered in 5-30ml distilled water, fully swelling dissolving, swelling is completely
, it is for use to form solution E；
F) cation guar gum 0.05-0.15g is weighed, is scattered in 5-10ml distilled water, fully swelling dissolving is molten
It is swollen complete, it is for use to form solution F；
G) menthol 0.01-2g, Paeonol 0.01-2g are weighed, is scattered in 5-10ml 70%-85% ethyl alcohol, is filled
Dissolving is divided to form solution G for use；
H) it by solution A, solution B, solution C, solution D, solution E, solution F, solution G, 0.1%-0.5%, is sufficiently stirred
Even to put 40-70 DEG C of drying of baking oven at being coated on non-woven fabrics immediately after sticky fluid, cutting, packaging are stopped to get a kind of anti-inflammatory
The cataplasm of pain.
Various composition in the present invention is as follows：
Safflower invigorate blood circulation, removing blood stasis and analgesics, dissipate wet effect going to swell.For abdominal mass lump in the abdomen, traumatic injury, arthralgia, sore, the stasis of blood
Hemotoncus pain, hemostasis costalgia etc., are usually used in varication, and peripheral neuritis promotes blood circulation, and treat lower limb numbness or livid purple etc.
Congestion.《Compendium of Materia Medica》Cloud：" promoting blood circulation, moisturizes, and relieves pain, and dissipates swollen, promoting menstruation.”《Book on Chinese herbal medicine is new again》Cloud：" inducing diuresis for removing edema ".《Between outer land
It is secret square》Cloud：" it is swollen to control all：Safflower, it is ripe rub to smash take juice to take it.”《First aid is just square》Cloud：It " controls bruise and wall weighs wounded：River fiber crops
One point, root of Aucklandia lappa Decne two divides, and safflower three divides, and Radix Glycyrrhizae four is divided.It is raw to use, it grinds, yellow rice wine is sent down." safflower has analgesia, calmness and anti-inflammatory work
With.
Radix Notoginseng has the effect of dissipate stasis of blood hemostasis, detumescence ding-tong.Traumatic hemorrhage is cured mainly, chest and abdomen shouting pain falls servant's swelling and pain, tiger stings snake
Hinder all diseases etc..《Compendium of Materia Medica》Cloud：" pseudo-ginseng hemostatic dissipates blood, analgesic therapy.Golden sword arrow wound, fall flutter cane sore, blood goes out more than person, chew rotten
It applies, or it is mixed for end, blood is i.e. only.”《Jade seizes medicine solution》Cloud：" Radix Notoginseng and battalion stop blooding, the row stasis of blood of promoting blood circulation, row hemostasis and hold back new blood.”
《Compendium of Materia Medica is newly organized》It records：Roots of Panax Notoginseng, the god's medicine of hemostasis.No matter the blood of upper, middle and lower, it is all to have outer more person, simply it is private also
Effect, is incorporated in then more refreshing in rich in nutrition medicine.Therefore it is always burn and scald scar, operation scar using Radix Notoginseng as traumatology Incised wound medicine
Trace, keloid patients, constitution containing scar can also use, and can inhibit scar hyperplasia.
And own promoting blood circulation to remove blood stasis, wind-expelling pain-stopping, detoxify desinsection.Traumatic injury is cured mainly, is fractured, Amenorrhea, (the Chinese medicine such as arthralgia pain due to rheumatism
Rheumatism bi Zheng scope includes the diseases such as the rheumatic arthritis of doctor trained in Western medicine, rheumatoid arthritis).《National Chinese herbal medicine compilation》It records
And oneself " relaxing tendons and activating collaterals, wind-expelling pain-stopping, subdhing swelling and detoxicating cure mainly traumatic injury, lumbago, skelalgia of rheumatism, furuncle swelling toxin, venomous snake bite ".
《Chinese book on Chinese herbal medicine》It records and oneself cures mainly：Traumatic injury, fracture, Amenorrhea, arthralgia pain due to rheumatism etc..《The civil common herbal medicine in Zhejiang》Record and
Oneself：Blood-stasis-dissipating blood-circulation-promoting, antibacterial anti-inflammatory.It controls and gets injured by a fall, sprain, fracture, furuncle etc..
Paeonol has the function of calm, analgesia, anti-inflammatory, antipyretic and inhibition allergy.To pressure tail, the physics such as acetic acid or
Pain caused by chemical factor has apparent analgesic activity.To by carrageenan, egg white, formaldehyde, histamine, serotonin, slow
Inflammatory reaction caused by kassinin kinin, dimethylbenzene and endotoxin etc., significantly inhibits.To typhoid vaccine, triple vaccine etc.
Caused body temperature increases, and has apparent refrigeration function.Inhibiting effect is all had to II, III, IV allergic reaction type.Paeonol
Anti-inflammatory, swelling and pain relieving, antiallergy have preferable treatment and health-care effect to courbature.
Menthol, ethyl alcohol, glycerine are skin penetration enhancer, in the case where the joint rush of three oozes effect, are greatly facilitated
The Transdermal absorption of both effectiveness ingredient Paeonol, safflower extract, Notogineng Extract and own root extract.
Paeonol, safflower extract, Notogineng Extract and own root extract complement each other, and play and dissipate the stasis of blood well, disappear
Swollen, analgesic therapy effect.Cataplasm smell of the present invention is fresh and clean, and homogeneous, viscosity is suitable, and skin tracing ability is good, without residual
It stays, can paste repeatedly, it is easy to use, the pain symptom of neck-shoulder pain, lumbago and leg pain can be effectively relieved.
Specific implementation mode
Following embodiments are further explanations for the content of present invention using as the explaination to the technology of the present invention content, but
The present invention substantive content be not limited in described in following embodiments, those skilled in the art can with and should know appoint
What simple change or replacement based on true spirit should all belong to protection domain of the presently claimed invention.
The preparation of saffron aqueous solution：
Safflower 15g is taken, 15 times of distilled water are added, 1h is extracted with reflux extraction, collects extracting solution, add 12 times of distillations
Water, extracts 1.5h with reflux extraction, collects extracting solution, then add 10 times of distilled water, extracts 1h with reflux extraction, often
Secondary filtering filtrate will merge three times, and filtrate is concentrated into 2 times of safflower weight, filters to obtain the final product.
The preparation of Radix Notoginseng alcohol extract：
Radix Notoginseng 50g is taken, coarse powder is ground into, is extracted 3 times with circumfluence method, 13 times of 75% ethyl alcohol is added for the first time, is impregnated
40min extracts 1.5h, collects extracting solution, and second of addition, 12 times of 75% ethyl alcohol extracts 1h, collects extracting solution, and third time is added 9
75% ethyl alcohol extracts 1h again, filters every time, filtrate will merge three times, filtrate be concentrated into 3 times of three seven weights, and filter to obtain the final product.
And the preparation of own root Aqueous extracts：
It takes and own root 70g, is ground into coarse powder, 11 times of distilled water are added in refluxing extraction 3 times for the first time, extract 1.5h, collect
Extracting solution adds 10 times of distilled water for the second time, and refluxing extraction 1h collects extracting solution, and 8 times of distilled water, extraction is added in third time
1h is filtered every time, filtrate will be merged three times, and filtrate is concentrated into and 1 times of own root weight, filters to obtain the final product.
Embodiment 1
The preparation of cataplasm includes the following steps：
A) saffron aqueous solution 2ml, Radix Notoginseng alcohol extract 2ml and own root Aqueous extracts 3ml are measured and is sufficiently stirred mixing, as molten
Liquid A is for use；
B) 10ml glycerine is measured, 0.10g Sodium Polyacrylates is weighed and is scattered in glycerine, 50ml distilled water is added, stirring is equal
It is even, it stands 3 hours and waits for that it is swollen dissolving naturally, swelling is complete, and it is for use to form solution B；
C) ice crystal forming agent 0.05g is weighed, is scattered in 20ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution C；
D) hydroxyethyl cellulose 0.05g is weighed, is scattered in 10ml distilled water, fully swelling dissolving, swelling is completely
, it is for use to form solution D；
E) carbomer 0.05g is weighed, is scattered in 15ml distilled water, fully swelling dissolving, swelling is complete, shape
It is for use at solution E；
F) cation guar gum 0.05g is weighed, is scattered in 8ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution F；
G) menthol 0.15g, Paeonol 0.90g are weighed, is scattered in 75% ethyl alcohol of 7ml, fully dissolving is formed molten
Liquid G is for use；
H) by solution A, solution B, solution C, solution D, solution E, solution F, solution G, 0.2% ethylparaben alcoholic solution
0.05g is mixed, and is coated on non-woven fabrics immediately after stirring into sticky fluid, and 60 DEG C of drying of baking oven, cutting, packet are put
Dress is to get a kind of cataplasm of anti-inflammatory analgetic.
Embodiment 2
The preparation of cataplasm includes the following steps：
A) saffron aqueous solution 5ml, Radix Notoginseng alcohol extract 5ml and own root Aqueous extracts 5ml are measured and is sufficiently stirred mixing, as molten
Liquid A is for use；
B) 20ml glycerine is measured, 0.15g Sodium Polyacrylates is weighed and is scattered in glycerine, 80ml distilled water is added, stirring is equal
It is even, it stands 3 hours and waits for that it is swollen dissolving naturally, swelling is complete, and it is for use to form solution B；
C) ice crystal forming agent 0.15g is weighed, is scattered in 45ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution C；
D) hydroxyethyl cellulose 0.15g is weighed, is scattered in 20ml distilled water, fully swelling dissolving, swelling is completely
, it is for use to form solution D；
E) carbomer 0.15g is weighed, is scattered in 30ml distilled water, fully swelling dissolving, swelling is complete, shape
It is for use at solution E；
F) cation guar gum 0.15g is weighed, is scattered in 10ml distilled water, fully swelling dissolving, swelling is completely
, it is for use to form solution F；
G) menthol 1g, Paeonol 1g are weighed, is scattered in 75% ethyl alcohol of 10ml, fully dissolving forms solution G and waits for
With；
H) by solution A, solution B, solution C, solution D, solution E, solution F, solution G, 0.2% ethylparaben alcoholic solution
0.2g is mixed, and is coated on non-woven fabrics immediately after stirring into sticky fluid, and 60 DEG C of drying of baking oven, cutting, packet are put
Dress is to get a kind of cataplasm of anti-inflammatory analgetic.
Embodiment 3
The preparation method of anti-inflammatory analgetic cataplasm, includes the following steps：
A) saffron aqueous solution 3ml, Radix Notoginseng alcohol extract 3ml and own root Aqueous extracts 3ml are measured and is sufficiently stirred mixing, as molten
Liquid A is for use；
B) 10ml glycerine is measured, 0.09g Sodium Polyacrylates is weighed and is scattered in glycerine, 50ml distilled water is added, stirring is equal
It is even, it stands 3 hours and waits for that it is swollen dissolving naturally, swelling is complete, and it is for use to form solution B；
C) ice crystal forming agent 0.05g is weighed, is scattered in 6ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution C；
D) hydroxyethyl cellulose 0.05g is weighed, is scattered in 5ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution D；
E) carbomer 0.05g is weighed, is scattered in 5ml distilled water, fully swelling dissolving, swelling is complete, shape
It is for use at solution E；
F) cation guar gum 0.05g is weighed, is scattered in 6ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution F；
G) menthol 0.09g, Paeonol 0.09g are weighed, is scattered in 75% ethyl alcohol of 6ml, fully dissolving is formed molten
Liquid G is for use；
H) by solution A, solution B, solution C, solution D, solution E, solution F, solution G, 0.2% ethylparaben alcoholic solution
0.4g is mixed, and is coated on non-woven fabrics immediately after stirring into sticky fluid, and 50 DEG C of drying of baking oven, cutting, packet are put
Dress is to get a kind of cataplasm of anti-inflammatory analgetic.
Test example
The physicochemical property detection of the cataplasm of anti-inflammatory analgetic obtained by embodiment 1-3 is as follows：
1.1 character
This product smell is fresh and clean, homogeneous, and viscosity is suitable, and skin tracing ability is good, noresidue, can paste repeatedly.
1.2 organoleptic indicator
(1) film residual：Cataplasm 5 is taken, whether after 180 degree stripping, see has residual on polyethylene film.Noresidue
10 points of note, 50% or more 5 points of note of residual.
(2) flexibility：Sense organ is given a mark, 10 points most easy to remember, worst 5 points of note.
(3) stretchability：Easy to apply, lotion is uniform, and unbroken noodles remember 10 points, and not easy to apply, the easy broken strip of lotion remembers 5 points.
(4) lotion uniformity：Prepared lotion should be uniform, fine and smooth, grainless micelle.It is 10 points most easy to remember, worst note 5
Point.
(5) skin tracing ability：Molding cataplasm is affixed at wrist back, is not fallen off under firmly getting rid of 10, parallel 5 parts of examinations
It tests.5 are remembered 10 points without the person of falling off, and 5 persons that do not fall off remember 5 points.
(6) stickup property repeatedly：It ceaselessly sticks, take off 10 times, parallel 5 parts of samples, effect is 10 points most easy to remember, worst note 5
Point.
By above-mentioned 6 institutes score value adduction using total score (S) as comprehensive evaluation index.
1 comprehensive evaluation result of table
| Organoleptic indicator | Number of cases | Average value |
| Film residual | 10 | 9.8 |
| Flexibility | 10 | 10 |
| Stretchability | 10 | 9.6 |
| Lotion uniformity | 10 | 9.5 |
| Skin tracing ability | 10 | 10 |
| Stickup property repeatedly | 10 | 9.8 |
| Summation | 60 | 58.7 |
The anaphylaxis and irritant experiment of 1.3 cataplasms：
Small white mouse back cuts off hair, pastes the cataplasm that is prepared by embodiment 1,2,3 respectively in cutting plucked position, and do not have
The position of patch is compared, and no significant difference then shows that this product is nonirritant and anaphylaxis.
The clinical effectiveness of 1.4 cataplasms is tested：
Choosing 150 has the patient of inflammation neck-shoulder pain, lumbago and leg pain as object is tried out, and three groups is arbitrarily divided into, respectively with implementation
Cataplasm prepared by example 1,2,3 is affixed on painful area, and daily 1 patch, usage time is 7 days.Generated effect standard：It is effective,
Pain disappears；Effectively, pain relief；In vain, symptom remains unchanged.
The clinical trial results of 2 cataplasm of table
| It is effective | Effectively | In vain | Efficient (%) | |
| Example 1 | 38 | 10 | 2 | 96 |
| Example 2 | 35 | 14 | 1 | 98 |
| Example 3 | 34 | 13 | 3 | 94 |
Claims (5)
1. a kind of anti-inflammatory analgetic cataplasm, the raw material containing following dosage proportioning in ointment：
2. anti-inflammatory analgetic cataplasm according to claim 1, which is characterized in that the saffron aqueous solution passes through with lower section
Method is prepared：
It takes safflower appropriate, 10-18 times of distilled water is added, extract 1-2h with reflux extraction, collect extracting solution, add 10-15
Times distilled water extracts 1-2h with reflux extraction, collects extracting solution, then add 8-12 times of distilled water, use reflux extraction
It extracts 0.5-1h, filters every time, filtrate will merge three times, filtrate is concentrated into 1-3 times of safflower weight, filters to obtain the final product.
3. anti-inflammatory analgetic cataplasm according to claim 1, which is characterized in that the Radix Notoginseng alcohol extract passes through with lower section
Method is prepared：
It takes Radix Notoginseng appropriate, is ground into coarse powder, extracted 3 times with circumfluence method, 10-15 times of 60%-85% ethyl alcohol is added for the first time, impregnate
15-55min extracts 1-2h, collects extracting solution, and 9-15 times of 60%-85% ethyl alcohol of second of addition extracts 1-2h, collects extraction
Liquid, third time are added 8-12 times of 60%-85% ethyl alcohol and extract 0.5-1.5h, filter every time, filtrate will merge three times, filtrate concentration
To 1-3 times of three seven weights, filter to obtain the final product.
4. anti-inflammatory analgetic cataplasm according to claim 1, which is characterized in that described and own root Aqueous extracts pass through following
Method is prepared：
It takes and own root is appropriate, be ground into coarse powder, 10-15 times of distilled water is added in refluxing extraction 3 times for the first time, extracts 1-2h, collects
Extracting solution adds 9-14 times of distilled water for the second time, and refluxing extraction 1-2h collects extracting solution, and third time is added 7-10 times and distills
Water extracts 0.5-1.5h, filters every time, filtrate will merge three times, and filtrate is concentrated into and 1-3 times of own root weight, filters to obtain the final product.
5. the preparation method of claim 1-4 any one of them anti-inflammatory analgetic cataplasms, it is characterised in that：Including following steps
Suddenly：
A) saffron aqueous solution 2-5ml, Radix Notoginseng alcohol extract 2-5ml and own root Aqueous extracts 2-5ml are measured and is sufficiently stirred mixing, as
Solution A is for use；
B) 5-30ml glycerine is measured, 0.05-0.15g Sodium Polyacrylates is weighed and is scattered in glycerine, 40-80ml distilled water is added,
It stirs evenly, stands 2-4 hours and wait for that it is swollen dissolving naturally, swelling is complete, and it is for use to form solution B；
C) ice crystal forming agent 0.05-0.15g is weighed, is scattered in 5-50ml distilled water, fully swelling dissolving, swelling is completely
, it is for use to form solution C；
D) hydroxyethyl cellulose 0.05-0.15g is weighed, is scattered in 5-20ml distilled water, fully swelling dissolving has been swollen
It is complete, it is for use to form solution D；
E) carbomer 0.05-0.15g is weighed, is scattered in 5-30ml distilled water, fully swelling is dissolved, and swelling is completely
Can, it is for use to form solution E；
F) cation guar gum 0.05-0.15g is weighed, is scattered in 5-10ml distilled water, fully swelling dissolving has been swollen
It is complete, it is for use to form solution F；
G) menthol 0.01-2g, Paeonol 0.01-2g are weighed, is scattered in 5-10ml 70%-85% ethyl alcohol, it is fully molten
It is for use that solution forms solution G；
H) by solution A, solution B, solution C, solution D, solution E, solution F, solution G, 0.1%-0.5% ethylparaben alcoholic solution
0.05-0.4g is mixed, and is coated on non-woven fabrics immediately after stirring into sticky fluid, and 40-70 DEG C of drying of baking oven is put,
Cutting is packed to get a kind of cataplasm of anti-inflammatory analgetic.
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| CN104258067A (en) * | 2014-09-12 | 2015-01-07 | 皖南医学院 | Pharmaceutical composition for cataplasm, cataplasm and preparation process of pharmaceutical composition |
| CN104415310A (en) * | 2013-08-28 | 2015-03-18 | 杜淑卿 | Traditional Chinese medicine patch capable of dredging collaterals and relieving pain |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104415310A (en) * | 2013-08-28 | 2015-03-18 | 杜淑卿 | Traditional Chinese medicine patch capable of dredging collaterals and relieving pain |
| CN104258067A (en) * | 2014-09-12 | 2015-01-07 | 皖南医学院 | Pharmaceutical composition for cataplasm, cataplasm and preparation process of pharmaceutical composition |
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