CN1052648C - Repellent analgesic ointment for cancer or tumor - Google Patents

Abstract

The present invention relates to an external medicine of a rpellent analgesic ointment for cancer or tumor, which is composed of realgar, Indian Rorippa Herb, rhubarb, mirabilite, stir-fried fankincense, myrrh, croton, alum, semen momordicae, nux vomica, radix, borneol, camphor, natural indigo, kansui roots, glycyrrhiza, turtle shells, ROSIN, ichthammol ointment, honey, alcohol, dimethyl sulfoxide, radix, airpotato yam, toad venom, cantharis and pokeberry roots. The ointment has the functions of eliminating sore, eliminating toxic material, activating blood circulation, dissipating blood stasis, reducing swollen and relieving pain. The present invention has the advantages that the limitation pain of the liver part and superficial tumors and the total effective rate of tumor reduction can reach 68.6%, and the effective rate of alleviating pain of primarily secondary cancer of liver; the present invention is changed for three days and has no side effect.

Description

Repellent analgesic ointment for cancer or tumor

This invention relates to anti-tumor medicine, is a kind of carcinoma reducing swelling and alleviating pain medicine for external use of inner disease outer treat.

At present, the Therapeutic Method of malignant tumor is broadly divided into three kinds: the one, operative treatment finds that about 80% above patient is late period when one, has lost the surgical engine meeting; The 2nd, chemotherapy, its side effect is big, mostly is disposable therapy, once recurrence or transfer are then powerless; The 3rd, take medicine, though the whole body administration has antitumor action, but the composition that affacts corpus carcinosus seldom, kind of the analgesic activity that disappears is very little, because Chinese medicine medicine for preventing mostly contains hypertoxic composition, to normal organ with organize toxigenicity reaction and side effect, in a word the treatment of malignant tumor is still the difficult problem of medical circle easily.

" repellent analgesic ointment for cancer or tumor " that the purpose of this invention is to provide a kind of inner disease outer treat loses opportunity to solve the late tumor patient operative treatment, and chemotherapy side effect is big, mostly be disposable therapy, take medicine act on corpus carcinosus composition seldom, the Repercusion analgesia effect is very little, and the big problem of toxic and side effects.

The object of the present invention is achieved like this: this ointment is made up of Realgar, Radix Et Rhizoma Rhei, Radix Notoginseng, Natrii Sulfas, Olibanum (processed), Myrrha (processed), Fructus Crotonis, Semen Momordicae, Alumen, Semen Strychni(processed), Radix Aconiti Preparata, Borneolum Syntheticum, Camphora, Indigo Naturalis, Radix Kansui (processed), Radix Glycyrrhizae, Carapax Trionycis (processed), Colophonium, Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Bulbiferae, Venenum Bufonis, Mylabris Phalerata (processed), system Radix Phytolaccae, YUSHIZHI RUANGAO, Mel, ethanol, dimethyl sulfoxide, Oleum Ricini, and its preparation dosage standard weights is such as following:

Realgar 2.27-2.66% Radix Notoginseng 4.43-5.10%

Radix Et Rhizoma Rhei 4.97-5.68% Natrii Sulfas 4.43-5.10%

Olibanum (processed) 2.90-3.55% Myrrha (processed) 2.90-3.55%

Fructus Crotonis 0.49-0.67% Alumen 4.43-5.10%

Semen Momordicae 4.97-5.68% Semen Strychni (processed) 2.21-2.50%

Radix Aconiti Preparata 2.41-2.84% Borneolum Syntheticum 1.14-1.50%

Camphora 1.14-1.50% Indigo Naturalis 2.41-2.84%

Radix Kansui (processed) 4.43-4.55% Radix Glycyrrhizae 2.41-2.84%

Carapax Trionycis (processed) 4.97-5.68% Colophonium 8.52-9.96%

Radix Aconiti Kusnezoffii Preparata 0-2.66% Rhizoma Dioscoreae Bulbiferae 0-4.43%

Venenum Bufonis 0-0.67% Mylabris Phalerata (processed) 0-0.67%

System Radix Phytolaccae 0-2.66% YUSHIZHI RUANGAO 4.91-5.68%

Mel 8.52-9.50% ethanol 9.10-11.36%

Dimethyl sulfoxide 8.52-9.50% Oleum Ricini 0-7.50%

Its production technology comprises drug screening, the process of preparing Chinese medicine, pulverizes, sieves, is mixed, grinding, packaging process.

(1), Colophonium selects powdery Colophonium for use, Radix Et Rhizoma Rhei is selected Radixet Rhizoma Rhei for use; Realgar is selected Realgar for use; Ethanol is selected 95% above ethanol for use, Fructus Crotonis peeling, Semen Momordicae peeling;

(2), Olibanum (processed): Olibanum is put in the pot, sprayed rice vinegar when frying to surface melting with slow fire, continuing to fry extremely, outer clear transparent only cools standby;

(3), Myrrha (processed) is with Olibanum (processed) technology;

(4), Semen Strychni (processed): get clean sand and put in the pot and make popular, put into Semen Strychni then, fry to being buff and heaving and end, taking-up is sieved, and it is standby to remove sand;

(5), Radix Kansui (processed): get Radix Kansui and mix thoroughly, put then in the pot and fry to little dried, take out oven dry with slow fire with rice vinegar; Radix Kansui: rice vinegar=10: 3;

(6), Rhizoma Dioscoreae Bulbiferae: remove fibrous root, clean, dry then or dry;

(7), Mylabris Phalerata (processed): remove foot, wing, rice and Mylabris are gone in the pot together, stir-fry gently, treat to take out when rice is yellow black, it is standby to remove the grain of rice;

(8), Carapax Trionycis (processed): get clean sand and put in the pot and make popular, put into Carapax Trionycis then, fry to the surface and be little yellow taking-up, sieve shakeout is put in the rice vinegar basin and is slightly leached, and uses water rinse, dries or dry standby then;

(9), Radix Aconiti Preparata: Radix Aconiti is put the urgent stir-fry of useing force in the pot, fry to little heaving and break, taking-up cools, 2-3 time so repeatedly;

(10), Radix Aconiti Kusnezoffii Preparata is with Radix Aconiti Preparata technology;

(11), the system Radix Phytolaccae is with Radix Kansui (processed) technology;

(12), with Realgar, Radix Notoginseng, Radix Et Rhizoma Rhei, Natrii Sulfas, Olibanum (processed), Myrrha (processed), Fructus Crotonis, Semen Momordicae, Alumen, Semen Strychni (processed), Radix Aconiti Preparata, Indigo Naturalis, Radix Kansui (processed), Radix Glycyrrhizae, Carapax Trionycis (processed), Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Bulbiferae, Venenum Bufonis, Mylabris Phalerata (processed), the system Radix Phytolaccae mixes by preparation dosage standard to be pulverized with pulverizer, cross 120 mesh sieves, put into the ceramic vessel of belt stirrer then, add Colophonium in proportion, Borneolum Syntheticum and Camphora and alcoholic solution, add dimethyl sulfoxide while stirring, YUSHIZHI RUANGAO, Mel, Oleum Ricini is stirred into to be in harmonious proportion to take out behind the cream and puts into the further ground and mixed of grinder.

Using method: above-mentioned ointment be can be made into the product plaster, perhaps make plaster and protect bag, earlier determine the drug of topical application zone during use with coloured pencil, should make drug of topical application district greater than tumor body 20-60mm to the carcinoma patient, should be to cancer pain patient with the plaster capsule in cancer pain position more very, drug of topical application area is decided according to pain scope meal with wine property.Changed once in three days, use hot water bag hot compress 2-4 hour winter, but pain relieving in general 10 to 15 minutes, pain relieving 10 days was a course of treatment, dispersing tumor one month was a course of treatment.

This invention compared with prior art has the following advantages: 1) this ointment has the phagedenoma counteracting toxic substances, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain effect, to liver and show shallow tumor limitation pain, the tumor body dwindles total effective rate and reaches 68.6%, the alleviating pain total effective rate reaches 89 7%, can reach more than 96% former secondary liver cancer pain relieving effective percentage, also can play assosting effect deep internal organs tumor; 2) have tumor body drug level height, longer duration; 3) easy to use, have no side effect, use no addiction continuously; 4) resting period long, long-term storage is not gone mouldy.

Be described further below in conjunction with example:

The embodiment weight ratio

Realgar 2.49% Radix Notoginseng 4.98% Radix Et Rhizoma Rhei 4.98%

Myrrha (processed) 2.98% Natrii Sulfas 4.98% Olibanum (processed) 2.98%

Fructus Crotonis 0.50% Semen Momordicae 4.98% Alumen 4.98%

Semen Strychni (processed) 2.49% Radix Aconiti Preparata 2.49% Borneolum Syntheticum 1.49%

Camphora 1.49% Indigo Naturalis 2.49% Radix Kansui (processed) 4.98%

Radix Glycyrrhizae 2.49% Carapax Trionycis (processed) 4.98% Colophonium 9.95%

YUSHIZHI RUANGAO 4.98% Mel 9.45% ethanol 9.95%

Dimethyl sulfoxide 8.92% specification:

1. drug screening:

(1), medical material mildew and rot, free from insect pests is selected totally, do not had to Chinese herbal medicine for use;

(2) Colophonium adopts powder shape Colophonium, and Radix Et Rhizoma Rhei is selected Radixet Rhizoma Rhei for use, and ethanol purity is selected 95% above ethanol for use, and Realgar is selected Realgar for use, the Semen Momordicae peeling.

2. concoct:

(1), Olibanum (processed): Olibanum is put in the pot, sprayed best rice vinegar when frying to surface melting, continue stir-fry to outer clear transparent and end with slow fire; Olibanum: rice vinegar=50: 3;

(2), Myrrha (processed) is with Olibanum (processed) technology;

(3), Semen Strychni (processed): get sharp sand and put in the pot and make popular, put into Semen Strychni then, fry to being buff and heaving, taking-up is sieved, and it is standby to remove sand;

(4), Fructus Crotonis: soak and mix with heavy-gravity rice water or the noodle soup endured, treat that skin is drenched after, put in the baking oven or under the daylight and tan by the sun, skin is broken, rubbing peeling with the hands, to get core standby;

(5), Radix Kansui (processed): get clean Radix Kansui and mix Radix Kansui with rice vinegar thoroughly: rice vinegar=10: 3, put then in the pot to fry to little and do with slow fire, take out dry for standby;

(6), Rhizoma Dioscoreae Bulbiferae goes fibrous root to clean, and dries or dry standby;

(7), Mylabris Phalerata (processed): Mylabris removes foot, wing, and rice and Mylabris are gone in the pot together, stir-fries gently, treats to take out when rice is yellow black, removes the grain of rice, Mylabris: rice=5: 1;

(8), Carapax Trionycis (processed): get clean sand and put in the pot and make popular, put into Carapax Trionycis then, fry and be little yellow taking-up to the surface and remove sand, put in the rice vinegar basin and slightly soak, use water rinse then, put drying in oven or dry standby, Carapax Trionycis: rice vinegar=10: 3

(9), Radix Aconiti Preparata: Radix Aconiti is put the urgent stir-fry of useing force in the pot, fry to little heaving and break, taking-up cools, 2-3 time so repeatedly;

(10), Radix Aconiti Kusnezoffii Preparata is with Radix Aconiti Preparata technology;

(11), the same Radix Kansui (processed) of system Radix Phytolaccae concocting method;

3. pulverize: Realgar, Radix Notoginseng, Radix Et Rhizoma Rhei, Natrii Sulfas, Olibanum (processed), Myrrha (processed), Fructus Crotonis, Semen Momordicae, Alumen, Semen Strychni (processed), Radix Aconiti Preparata, Indigo Naturalis, Radix Kansui (processed), Radix Glycyrrhizae, Carapax Trionycis (processed), Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Bulbiferae, Venenum Bufonis, Mylabris Phalerata (processed), system Radix Phytolaccae are mixed in proportion put into crusher for crushing.

4. sieve: the powder of operation 3 is crossed 120 orders industry sieve, Colophonium is sieved the continuation crushing screening on the sieve separately.

5. be mixed: the ceramic vessel of operation 3 powder that sieve being put into belt stirrer, add Colophonium in proportion, Borneolum Syntheticum, Camphora are put into ethanol in proportion to be dissolved, pour into then in the ceramic vessel and stir, add dimethyl sulfoxide, YUSHIZHI RUANGAO, Mel, Oleum Ricini while stirring, be stirred into to be in harmonious proportion and take out behind the cream.

6. grind: the cream that will be in harmonious proportion is put into further ground and mixed of three cylinder roller mills.

7. encapsulation: ground mediation cream is put into airtight ceramic vessel seal up for safekeeping standby.

Claims (3)

1. repellent analgesic ointment for cancer or tumor compositions, form by Realgar, Radix Et Rhizoma Rhei, Radix Notoginseng, Natrii Sulfas, Olibanum (processed), Myrrha (processed), Fructus Crotonis, Semen Momordicae, Alumen, Semen Strychni(processed), Radix Aconiti Preparata, Borneolum Syntheticum, Camphora, Indigo Naturalis, Radix Kansui (processed), Radix Glycyrrhizae, Carapax Trionycis (processed), Colophonium, Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Bulbiferae, Venenum Bufonis, Mylabris Phalerata (processed), system Radix Phytolaccae, YUSHIZHI RUANGAO, Mel, ethanol, dimethyl sulfoxide, Oleum Ricini, it is characterized in that its preparation dosage standard weights is such as following:

Realgar 2.27-2.66% Radix Notoginseng 4.43-5.10%

Radix Et Rhizoma Rhei 4.97-5.68% Natrii Sulfas 4.43-5.10%

Olibanum (processed) 2.90-3.55% Myrrha (processed) 2.90-3.55%

Fructus Crotonis 0.49-0.67% Semen Momordicae 4.97-5.68%

Alumen 4.43-5.10% Semen Strychni (processed) 2.21-2.50%

Radix Aconiti Preparata 2.41-2.84% Borneolum Syntheticum 1.14-1.50%

Camphora 1.14-1.50% Indigo Naturalis 2.41-2.84%

Radix Kansui (processed) 4.43-4.55% Radix Glycyrrhizae 2.41-2.84%

Carapax Trionycis (processed) 4.97-5.68% Colophonium 8.52-9.96%

Radix Aconiti Kusnezoffii Preparata 0-2.66% Rhizoma Dioscoreae Bulbiferae 0-4.43%

Venenum Bufonis 0-0.67% macula lutea insect destructive of the roots of seedlings 0-0.67%

System Radix Phytolaccae 0-2.66% YUSHIZHI RUANGAO 4.91-5.68%

Mel 8.52-9.50% ethanol 9.10-11.36%

Dimethyl sulfoxide 8.52-9.50% Oleum Ricini 0-7.50%

According to the described repellent analgesic ointment for cancer or tumor preparation of compositions of claim 1 method comprise drug screening, the process of preparing Chinese medicine, pulverize, sieve, be mixed, grinding, packaging process, it is characterized in that:

(1), Colophonium selects powdery Colophonium for use, Radix Et Rhizoma Rhei is selected Radixet Rhizoma Rhei for use; Realgar is selected Realgar for use; Ethanol purity is selected 95% above ethanol for use, Fructus Crotonis peeling, Semen Momordicae peeling;

(2), Olibanum (processed): Olibanum put sprays rice vinegar in the pot when frying to surface melting with slow fire, continue then to fry to outer clear transparent only, cool standby;

(3), Myrrha (processed) is with Olibanum (processed) technology;

(4), Semen Strychni (processed): get clean sand and put in the pot and make popular, put into Semen Strychni then, fry to being yellow and heaving and end, taking-up is sieved, and it is standby to remove sand;

(5), Radix Kansui (processed): get Radix Kansui and mix thoroughly, Radix Kansui with rice vinegar: rice vinegar=10: 3, put then in the pot to fry to little and do with slow fire, take out oven dry;

(6), Rhizoma Dioscoreae Bulbiferae: remove fibrous root, clean, dry then or dry standby;

(7), Mylabris Phalerata (processed): Mylabris is removed foot, wing, rice and Mylabris are gone in the pot together, stir-fry gently, treat to take out when rice is yellow black, it is standby to remove the grain of rice;

(8), Carapax Trionycis (processed): get clean sand and put in the pot and make popular, put into Carapax Trionycis then, fry and be little to the surface and take out when yellow, sieve shakeout is put in the rice vinegar and is slightly leached, and uses water rinse, dries or dry standby then;

(9), Radix Aconiti Preparata: Radix Aconiti is put the urgent stir-fry of useing force in the pot, fry to little heaving and break, taking-up cools, 2-3 time so repeatedly;

(10), Radix Aconiti Kusnezoffii Preparata is with Radix Aconiti Preparata technology;

(11), the system Radix Phytolaccae is with Radix Kansui (processed) technology;

(12), with Realgar, Radix Notoginseng, Radix Et Rhizoma Rhei, Natrii Sulfas, Olibanum (processed), Myrrha (processed), Fructus Crotonis, Semen Momordicae, Alumen, Semen Strychni (processed), Radix Aconiti Preparata, Indigo Naturalis, Radix Kansui (processed), Radix Glycyrrhizae, Carapax Trionycis (processed), Radix Aconiti Kusnezoffii Preparata, Rhizoma Dioscoreae Bulbiferae, Venenum Bufonis, Mylabris Phalerata (processed), the system Radix Phytolaccae mixes by preparation dosage standard, pulverize with pulverizer, cross 120 mesh sieves then, put into the ceramic vessel of belt stirrer, add Colophonium then in proportion, add Borneolum Syntheticum, Camphora and alcoholic solution, add dimethyl sulfoxide while stirring, YUSHIZHI RUANGAO, Mel, Oleum Ricini is stirred into to be in harmonious proportion to take out behind the cream and puts into the further ground and mixed of grinder.

3. repellent analgesic ointment for cancer or tumor according to claim 1, its optimum weight ratio proportioning is:

Realgar 2.49% Radix Notoginseng 4.98% Radix Et Rhizoma Rhei 4.98%

Myrrha (processed) 2.98% Natrii Sulfas 4.98% Olibanum (processed) 2.98%

Fructus Crotonis 0.50% Semen Momordicae 4.98% Alumen 4.98%

Semen Strychni (processed) 2.49% Radix Aconiti Preparata 2.49% Borneolum Syntheticum 1.49%

Camphora 1.49% Indigo Naturalis 2.49% Radix Kansui (processed) 4.98%

Radix Glycyrrhizae 2.49% Carapax Trionycis (processed) 4.98% Colophonium 9.95%

YUSHIZHI RUANGAO 4.98% Mel 9.45% ethanol 9.95%

Dimethyl sulfoxide 8.96%