CN114288372A - A topical Chinese medicinal composition for treating tumor and cancer, and its preparation method - Google Patents
A topical Chinese medicinal composition for treating tumor and cancer, and its preparation method Download PDFInfo
- Publication number
- CN114288372A CN114288372A CN202111304670.9A CN202111304670A CN114288372A CN 114288372 A CN114288372 A CN 114288372A CN 202111304670 A CN202111304670 A CN 202111304670A CN 114288372 A CN114288372 A CN 114288372A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- cancer
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 122
- 201000011510 cancer Diseases 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000203 mixture Substances 0.000 title claims description 40
- 230000000699 topical effect Effects 0.000 title claims description 4
- 239000003814 drug Substances 0.000 claims abstract description 104
- 239000000463 material Substances 0.000 claims abstract description 28
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 15
- 241000382455 Angelica sinensis Species 0.000 claims abstract description 11
- 241000132012 Atractylodes Species 0.000 claims abstract description 9
- 241000131283 Cantharis Species 0.000 claims abstract description 9
- 241000258920 Chilopoda Species 0.000 claims abstract description 9
- 235000003405 Curcuma zedoaria Nutrition 0.000 claims abstract description 9
- 240000009138 Curcuma zedoaria Species 0.000 claims abstract description 9
- 241000244987 Daiswa polyphylla Species 0.000 claims abstract description 9
- 241000222336 Ganoderma Species 0.000 claims abstract description 9
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 9
- 244000197580 Poria cocos Species 0.000 claims abstract description 9
- 241000239226 Scorpiones Species 0.000 claims abstract description 9
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 9
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 claims abstract description 9
- 239000010446 mirabilite Substances 0.000 claims abstract description 9
- 235000019509 white turmeric Nutrition 0.000 claims abstract description 9
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 8
- 235000014375 Curcuma Nutrition 0.000 claims abstract description 8
- 244000164480 Curcuma aromatica Species 0.000 claims abstract description 8
- 235000006533 astragalus Nutrition 0.000 claims abstract description 8
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 8
- 241000131329 Carabidae Species 0.000 claims abstract description 7
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 5
- 239000007788 liquid Substances 0.000 claims description 80
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 27
- 238000006243 chemical reaction Methods 0.000 claims description 25
- 230000001965 increasing effect Effects 0.000 claims description 24
- 238000011282 treatment Methods 0.000 claims description 24
- 238000000605 extraction Methods 0.000 claims description 22
- 239000002904 solvent Substances 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 18
- 239000000052 vinegar Substances 0.000 claims description 18
- 235000021419 vinegar Nutrition 0.000 claims description 18
- 238000002791 soaking Methods 0.000 claims description 16
- 241000632227 Antenoron Species 0.000 claims description 12
- 241000546188 Hypericum Species 0.000 claims description 11
- 235000017309 Hypericum perforatum Nutrition 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 10
- 235000003717 Boswellia sacra Nutrition 0.000 claims description 9
- 235000012035 Boswellia serrata Nutrition 0.000 claims description 9
- 240000007551 Boswellia serrata Species 0.000 claims description 9
- 240000007311 Commiphora myrrha Species 0.000 claims description 9
- 235000006965 Commiphora myrrha Nutrition 0.000 claims description 9
- 239000004863 Frankincense Substances 0.000 claims description 9
- 235000007265 Myrrhis odorata Nutrition 0.000 claims description 9
- 244000179560 Prunella vulgaris Species 0.000 claims description 9
- 229920000742 Cotton Polymers 0.000 claims description 8
- 244000219416 Hypericum japonicum Species 0.000 claims description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 235000002594 Solanum nigrum Nutrition 0.000 claims description 8
- 241000219784 Sophora Species 0.000 claims description 8
- 235000008434 ginseng Nutrition 0.000 claims description 8
- 235000008113 selfheal Nutrition 0.000 claims description 8
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 7
- 244000020518 Carthamus tinctorius Species 0.000 claims description 7
- 235000002598 Inula helenium Nutrition 0.000 claims description 7
- 244000116484 Inula helenium Species 0.000 claims description 7
- 244000061457 Solanum nigrum Species 0.000 claims description 7
- 244000061520 Angelica archangelica Species 0.000 claims description 6
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 6
- 241000628997 Flos Species 0.000 claims description 5
- 240000004824 Trimezia steyermarkii Species 0.000 claims description 5
- 239000009136 dragon's blood Substances 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 210000000805 cytoplasm Anatomy 0.000 claims description 4
- 241001313855 Bletilla Species 0.000 claims description 3
- 241000701408 Euphorbia kansui Species 0.000 claims description 3
- 241000501743 Gentiana macrophylla Species 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 241000756943 Codonopsis Species 0.000 claims description 2
- 235000017617 Lonicera japonica Nutrition 0.000 claims description 2
- 244000167230 Lonicera japonica Species 0.000 claims description 2
- 241000218206 Ranunculus Species 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 240000004371 Panax ginseng Species 0.000 claims 2
- 208000002193 Pain Diseases 0.000 abstract description 31
- 230000036407 pain Effects 0.000 abstract description 31
- 230000000694 effects Effects 0.000 abstract description 28
- 210000004185 liver Anatomy 0.000 abstract description 5
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000000202 analgesic effect Effects 0.000 abstract description 3
- 230000001093 anti-cancer Effects 0.000 abstract description 2
- 231100001231 less toxic Toxicity 0.000 abstract description 2
- 244000272264 Saussurea lappa Species 0.000 abstract 1
- 235000006784 Saussurea lappa Nutrition 0.000 abstract 1
- 241000123725 Sophora tonkinensis Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 30
- 210000002784 stomach Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 14
- 229940126680 traditional chinese medicines Drugs 0.000 description 14
- 206010006187 Breast cancer Diseases 0.000 description 13
- 208000026310 Breast neoplasm Diseases 0.000 description 13
- 210000000952 spleen Anatomy 0.000 description 12
- 239000012530 fluid Substances 0.000 description 11
- 244000132619 red sage Species 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 241000510678 Falcaria vulgaris Species 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 210000004881 tumor cell Anatomy 0.000 description 8
- 210000003734 kidney Anatomy 0.000 description 7
- 241000208340 Araliaceae Species 0.000 description 6
- 230000035508 accumulation Effects 0.000 description 6
- 238000009825 accumulation Methods 0.000 description 6
- 210000000987 immune system Anatomy 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 238000002512 chemotherapy Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 230000000149 penetrating effect Effects 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 238000005728 strengthening Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000005075 mammary gland Anatomy 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000004083 survival effect Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 235000003826 Artemisia Nutrition 0.000 description 3
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 3
- 241000521456 Desmodium cuspidatum Species 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 206010046798 Uterine leiomyoma Diseases 0.000 description 3
- 238000001467 acupuncture Methods 0.000 description 3
- 244000030166 artemisia Species 0.000 description 3
- 235000009052 artemisia Nutrition 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000011049 filling Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000001376 precipitating effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 description 2
- 206010006272 Breast mass Diseases 0.000 description 2
- 206010008479 Chest Pain Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 241000208296 Datura Species 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 240000007164 Salvia officinalis Species 0.000 description 2
- 241000207763 Solanum Species 0.000 description 2
- 235000002634 Solanum Nutrition 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000005809 anti-tumor immunity Effects 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000000711 cancerogenic effect Effects 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 201000004101 esophageal cancer Diseases 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 206010016629 fibroma Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 208000004396 mastitis Diseases 0.000 description 2
- 230000007102 metabolic function Effects 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 235000005412 red sage Nutrition 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000007939 sustained release tablet Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 229960004380 tramadol Drugs 0.000 description 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 2
- 206010046766 uterine cancer Diseases 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 241000219068 Actinidia Species 0.000 description 1
- 235000009434 Actinidia chinensis Nutrition 0.000 description 1
- 244000298715 Actinidia chinensis Species 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010006298 Breast pain Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 206010008342 Cervix carcinoma Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 241000544061 Cuculus canorus Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 208000007358 Galactocele Diseases 0.000 description 1
- 240000001972 Gardenia jasminoides Species 0.000 description 1
- 241001071795 Gentiana Species 0.000 description 1
- 240000008669 Hedera helix Species 0.000 description 1
- 206010019851 Hepatotoxicity Diseases 0.000 description 1
- 241000334154 Isatis tinctoria Species 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000006662 Mastodynia Diseases 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 244000148137 Patrinia villosa Species 0.000 description 1
- 235000019109 Patrinia villosa Nutrition 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241001446509 Psoralea Species 0.000 description 1
- 241000915604 Scutellaria barbata Species 0.000 description 1
- 235000003205 Smilax rotundifolia Nutrition 0.000 description 1
- 240000009022 Smilax rotundifolia Species 0.000 description 1
- 240000002307 Solanum ptychanthum Species 0.000 description 1
- 241001671204 Stemona Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 206010048931 Uterine cyst Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000011394 anticancer treatment Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 201000010881 cervical cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 229960004126 codeine Drugs 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 235000005272 common selfheal Nutrition 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- BRTSNYPDACNMIP-FAWZKKEFSA-N dihydroetorphine Chemical compound O([C@H]1[C@@]2(OC)CC[C@@]34C[C@@H]2[C@](C)(O)CCC)C2=C5[C@]41CCN(C)[C@@H]3CC5=CC=C2O BRTSNYPDACNMIP-FAWZKKEFSA-N 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000000337 effect on mastitis Effects 0.000 description 1
- 238000001827 electrotherapy Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 239000003777 experimental drug Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 238000002575 gastroscopy Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 1
- 230000007686 hepatotoxicity Effects 0.000 description 1
- 231100000304 hepatotoxicity Toxicity 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000037451 immune surveillance Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000004283 incisor Anatomy 0.000 description 1
- 206010021654 increased appetite Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 210000002570 interstitial cell Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 201000010758 lactocele Diseases 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 208000014987 limb edema Diseases 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000822 natural killer cell Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940124636 opioid drug Drugs 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 208000025661 ovarian cyst Diseases 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000025421 tumor of uterus Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an external traditional Chinese medicine for resisting tumor and cancer and a preparation method thereof, and provides a traditional Chinese medicine which has less toxic and side effects and can effectively treat and even cure cancer, thereby relieving the pain of people suffering from cancer. The traditional Chinese medicinal materials comprise the following components: 50-70 parts of paris polyphylla, 50-60 parts of scorpion, 60-80 parts of centipede, 40-60 parts of ground beetle, 10-20 parts of cantharis, 70-80 parts of mirabilite, 15-25 parts of gecko, 80-100 parts of rhizoma alismatis, 55-65 parts of poria cocos, 35-45 parts of rhizoma atractylodis, 55-65 parts of bighead atractylodes rhizome, 60-70 parts of vietnamese sophora root, 70-80 parts of cuckoo-bud, 15-25 parts of angelica sinensis, 20-30 parts of curcuma zedoary, 35-45 parts of costus root, 15-25 parts of astragalus membranaceus, 55-65 parts of lucid ganoderma, 35-45 parts of folium isatidis, 20-30 parts of salvia miltiorrhiza and the like. The invention has the advantages of no need of oral administration, direct effect on focus, no passing through liver, good analgesic and anticancer effects, and the like.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an external traditional Chinese medicine for resisting tumor and cancer and a preparation method thereof.
Background
According to the statistics of the World Health Organization (WHO), about 1000 million people with cancer and about 700 million people with cancer all over the world are killed after cardiovascular diseases every year.
The current methods for treating tumor include taking anticancer drugs, surgery, chemotherapy, electrotherapy, radiotherapy, transplantation, etc.
The anti-cancer drugs comprise chemically synthesized drugs and traditional Chinese medicines, and the chemically synthesized drugs are easy to generate drug resistance for general patients and have strong toxic and side effects.
The traditional Chinese medicine is used in anticancer treatment for a long time, various compatible traditional Chinese medicine compositions appear, and the treatment is generally carried out by adopting an oral administration mode, but the mode has strong toxic and side effects and incomplete efficacy.
Therefore, there is a need to research anticancer Chinese medicines with better efficacy and less toxic and side effects.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine with small side effect for resisting tumor and cancer, which can fundamentally treat and even cure tumor and cancer, and relieve the suffering of patients and the pain of treatment.
The invention is realized by the following technical scheme:
an external traditional Chinese medicine for resisting tumor and cancer comprises the following components in parts by weight:
50-70 parts of paris polyphylla, 50-60 parts of scorpion, 60-80 parts of centipede, 40-60 parts of ground beetle, 10-20 parts of cantharis, 70-80 parts of mirabilite, 15-25 parts of gecko, 80-100 parts of rhizoma alismatis, 55-65 parts of poria cocos, 35-45 parts of rhizoma atractylodis, 55-65 parts of bighead atractylodes rhizome, 60-70 parts of subprostrate sophora, 70-80 parts of cuckoo-bud, 15-25 parts of angelica sinensis, 20-30 parts of curcuma zedoary, 35-45 parts of elecampane, 15-25 parts of astragalus membranaceus, 55-65 parts of lucid ganoderma, 35-45 parts of folium isatidis, 20-30 parts of salvia miltiorrhiza, 55-65 parts of flos daturae, 25-35 parts of angelica sinensis, 65-75 parts of radix codonopsis pilosulae, 60-80 parts of gentiana macrophylla, 35-45 parts of cotton stalk root, 15-25 parts of cortex acanthopanacis, 25 parts of radix stemonae, 10-20 parts of salvia miltiorrhiza, 10-20 parts of radix salviae miltiorrhizae, rhizoma pineae, rhizoma pinelliae, and rhizoma pinelliae, etc, 70-90 parts of bletilla, 70-90 parts of fructus psoraleae, 15-25 parts of ginseng, 30-40 parts of euphorbia kansui, 15-25 parts of raw myrrh, 15-25 parts of raw frankincense, 80-90 parts of mangnolia officinalis, 80-100 parts of herba patriniae, 55-65 parts of hypericum japonicum, 60-80 parts of solanum nigrum, 25-35 parts of sculellaria barbata, 25-35 parts of longhairy antenoron herb, 55-65 parts of selfheal, 45-55 parts of semen coicis, 80-90 parts of safflower and 25-35 parts of dragon's blood.
The invention deeply researches the pathogenesis of tumor cancer, which mainly comprises the following steps: the unhealthy diet can cause the activation of carcinogenic cells, the immunologic deficiency of human body, the poor gastrointestinal function, etc., which can cause the stubborn stool to produce a large amount of garbage and toxin which can not be discharged on time, and the cold-dampness, etc., which can easily cause the canceration and the metastasis and the diffusion of the body.
The manifestation of tumor cancer is: cancer cells are easy to spread to other places, pain, body cold, deficiency-cold of spleen and stomach, swelling and pain, nodules, stagnation of qi and blood stasis and the like
Aiming at the above pathogenesis, the symptomatic treatment strategy adopted by the invention is as follows: first, blocking the spread of cancer cells to the surroundings; secondly, carbuncle elimination and pain relief; thirdly, strengthening the spleen and nourishing the stomach; fourthly, dispelling cold and removing toxicity, detumescence and dissipating stagnation; fifthly, removing blood stasis and resolving tumor; sixth, improve the immunologic function, seventh, strengthen the bones and muscles, tonify the kidney and promote qi, the invention is to consider from various aspects of tumor cancer, the compatibility is rational, wherein:
first, blocking the spread of cancer cells to the surroundings
The micromolecule components in paris polyphylla, cantharis, datura flower, gecko, subprostrate sophora, cuckoo and the like have strong penetrating power, the efficacy of the medicine can reach focus directly, the micromolecule components firstly form a surrounding ring of the tumor cells, the nutrient input outside the ring is cut off, the moving range of the tumor cells is limited, the tumor cells are blocked from diffusing to the periphery, the normal cells are prevented from being damaged, the growth process of the tumor is effectively controlled, and pain is gradually relieved.
Secondly, cure abscess and alleviate pain
Clinically, the oral administration of opioid drugs such as amphetamine, codeine, morphine, dihydroetorphine and the like, and a plurality of analgesics such as subcutaneous or intravenous drugs are generally adopted; the medicine has great damage to the spleen and stomach of patients, causes gastrointestinal dysfunction, and has the side effects of constipation, hepatotoxicity damage, dizziness, nausea and vomiting of the patients.
The raw myrrh, the raw frankincense, the black nightshade herb, the barbed skullcap herb, the longhairy antenoron herb, the common selfheal fruit-spike and other medicines in the external liquid for treating the tumor have very good clinical analgesic effect, generally have very good effect on treating late-stage pain of the cancer, do not cause damage to the spleen and the stomach of a patient, and have no side effect phenomena of constipation, dizziness, nausea, vomiting and the like. The traditional Chinese medicines not only relieve the pain of patients, but also have the functions of promoting blood circulation, removing blood stasis and relieving swelling, and are beneficial to the treatment of patients.
Thirdly, strengthening the spleen and nourishing the stomach
If the intestines and the stomach of people are not normal in temperature and are too cold and less hot, the intestines and the stomach function of people are affected at this time, pathogenic qi stays in the intestines and the stomach, qi stagnation is caused, qi and blood do not circulate, accumulation is generated, and the accumulation is soil for breeding the tumor; clinically, people with cold physique in cancer patients account for about 70 percent, and for women, the body cold is a source of all diseases, and uterine fibroids, uterine cancer and breast cancer do not have a relationship with the body cold.
The external liquid for treating the tumor is the same as other tumor medicaments and causes damage to the spleen and the stomach to different degrees, so that the raw materials of the rhizoma atractylodis, the mangnolia officinalis, the bighead atractylodes rhizome, the semen coicis, the rhizoma alismatis, the poria cocos and the like are specially arranged for protecting spirit aiming at the spleen and the stomach, and the external liquid not only protects the organs of the spleen and the stomach, but also dispels wind and removes dampness, nourishes the stomach, strengthens the spleen, promotes tissue regeneration, promotes the metabolic functions of the liver and the kidney, balances the five internal organs of a human body, and keeps the function of good digestion.
Fourthly, dispelling cold and removing toxicity, detumescence and resolving masses
The theory of traditional Chinese medicine: accumulation of cold in the body, and cancer in the body; on the other hand, the exclamations of nine accumulations in ten people are marked, and cold pathogen enters meridians and collaterals and intestines and stomach from skin and hair, causing blood stasis or fluid accumulation, which accumulates over a long period of time. Not to be exaggeratedly said, various human diseases including cancer are not associated with "accumulation"; product, similar to "" on "", is mainly divided into: qi stagnation, blood stagnation, water stagnation, food stagnation, phlegm stagnation, alcohol stagnation, and meat stagnation, wherein the liver is injured by the qi stagnation, the blood vessel is injured by the blood stagnation, the kidney is injured by the water stagnation, the spleen and the stomach are injured by the food stagnation, and the large phlegm stagnation is caused.
The externally applied medicine for treating tumor is a tonic medicine for encephalating tumor and cancer cell, wherein scorpion, centipede, ground beeltle, mirabilite, euphorbia kansui, zedoary, dyers woad leaf, red sage root, large-leaved gentian, gardenia, red sage root, bletilla and glabrous greenbrier rhizome are matched to play a role in reducing swelling, softening hardness and dissipating stagnation, smoothing blood vessels, dissipating stasis, relieving swelling and pain, recovering elasticity, resisting pressure and other normal movement physiological functions.
Fifthly, removing blood stasis and eliminating tumor
The traditional Chinese medicine considers that the tumor is formed by viscera dysfunction and qi stagnation and blood stasis, and the qi-blood imbalance is the characteristic of the tumor. The components of safflower, peach kernel, angelica, dahurian patrinia herb, hypericum japonicum, dragon's blood and the like in the external liquid for treating the tumor focus on distinguishing and clearing qi and blood, and the external liquid is absorbed through human acupuncture points in a transdermal way by the principle of treating internal diseases by external therapy, and has the main effects of promoting blood circulation to remove blood stasis, eliminating stasis and dissipating stagnation, clearing heat and detoxicating, soothing liver and regulating qi, and dispersing blood stasis and relieving pain, so that a tumor body is softened and thoroughly dissipated, and the qi is regulated.
Sixth, improving immune function
The human body has 10 to 14 trillion individual cells, and millions of cells are genetically mutated each day due to the action of various carcinogenic factors. Some of the mutant cells will transform to malignant cells to form tumor cells, and the immune surveillance system can recognize the mutant cells and destroy them, so that the malignant cells do not form malignant tumors.
The malignant tumor is a systemic disease and manifests locally, and the treatment of the malignant tumor needs to be considered systemic and comprehensive treatment, so that single operation or radiotherapy and chemotherapy cannot be adopted.
Because the radiotherapy and chemotherapy can kill tumor cells and immune cells of an organism together, especially cancer cells which are not killed are mutated by stimulation of the radiotherapy and chemotherapy, and tumor stem cells are formed; the cell has strong vitality, is not sensitive to the original radiotherapy and chemotherapy and is not easy to be killed, so that people can not be helped in treatment and have no policy.
The anti-tumor immunity of the organism is mainly based on cellular immunity, cells participating in the anti-tumor immunity comprise T lymphocytes, K, NK cells and macrophages, the immunity function in the organism is mainly completed by the cells, a healthy immune system is very important for preventing and treating malignant tumors, and the organism can be prevented from being invaded by tumor cells only by keeping the health of the immune system.
The Chinese actinidia root and the cotton stalk root in the external liquid for treating tumor are the well-known traditional Chinese medicines, which are not recognized before, have the functions of distinguishing foreign matters invading in vivo, attacking tumor cells and expelling the tumor cells out of body, and have important effects on the immune system of a human body because the traditional Chinese medicines have high curative effect, do not damage the immune system and do not kill the immune cells.
Seventh step, strengthening bone and essence, tonifying kidney and raising qi
The kidney is the congenital origin, and has good qi and sufficient essence and blood. The psoralea fruit, lucid ganoderma, slenderstyle acanthopanax bark, sessile stemona root, ginseng, Chinese angelica, costustoot and astragalus root in the external liquid for treating tumor have unique biological immune activators which are implanted into focus of infection to induce the generation of various enzymes such as antioxidant enzyme and the like, promote the regeneration of bone cells, bone marrow hematopoietic cells and fat cells, fibroblasts and interstitial cells and ensure that the immune system can effectively prevent the invasion of inflammatory factors.
The invention preferably selects an external traditional Chinese medicine for resisting tumor and cancer, and the traditional Chinese medicine comprises the following components in parts by weight:
60 parts of paris polyphylla, 55 parts of scorpion, 70 parts of centipede, 50 parts of ground beetle, 15 parts of cantharis, 75 parts of mirabilite, 20 parts of gecko, 90 parts of rhizoma alismatis, 60 parts of poria cocos, 40 parts of rhizoma atractylodis, 60 parts of bighead atractylodes rhizome, 65 parts of subprostrate sophora, 75 parts of buttercup root, 20 parts of angelica, 25 parts of curcuma zedoary, 40 parts of elecampane, 20 parts of astragalus membranaceus, 60 parts of lucid ganoderma, 40 parts of folium isatidis, 25 parts of salvia miltiorrhiza, 60 parts of lonicera japonica, 30 parts of angelica sinensis, 70 parts of radix gentianae macrophyllae, 40 parts of cotton stalk root, 20 parts of cortex acanthopanacis, 30 parts of radix stemonae, 15 parts of salvia miltiorrhiza, 80 parts of rhizoma bletillae, 80 parts of fructus psoraleae, 20 parts of ginseng, 35 parts of kansui root, 20 parts of raw myrrh, 85 parts of raw frankincense, 85 parts of mangnolia officinalis, 90 parts of herba patriniae, 60 parts of hypericum japonicum, 70 parts of solanum nigrum, 30 parts of herba scutellariae barbatae, 30 parts of herba hypericum, 60 parts of longa, 30 parts of longhairy antenoron, 60 parts of longa, 50 parts of herba hypericum, 85 parts of herba hypericum, 30 parts of herba hypericum, 50 parts of herba hypericum japonicum, 50 parts of selfheal, 85 parts of safflower and 30 parts of dragon's.
The invention preferably selects an external traditional Chinese medicine for resisting tumor and cancer, and further comprises protoplasm mature vinegar, wherein the mass ratio of the protoplasm mature vinegar to the traditional Chinese medicinal materials is 2: 1-4: 1.
the invention preferably selects an external traditional Chinese medicine for resisting tumor and cancer, and also comprises a transdermal agent.
The invention preferably selects an external traditional Chinese medicine for resisting tumor and cancer, and the medicine is prepared into liquid, paste or patch.
A preparation method of an external traditional Chinese medicine for resisting tumor and cancer comprises the following steps:
step 1: soaking Chinese medicinal materials
Soaking the Chinese medicinal materials in original juice mature vinegar in a low-temperature reaction kettle to obtain a solid-liquid mixture;
step 2: adding a solvent, wherein the solvent is methanol and isopropanol;
and step 3: cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-8 to-12 ℃, increasing the gas pressure to 0.3 to 0.6MPa, and reacting for at least 20 minutes;
and 4, step 4: continuously cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-13 to-16 ℃, increasing the pressure to 1.3 to 1.6MPa, converting gas into liquid, increasing the volume of the material, and reacting for at least 30 minutes;
and 5: heating the solid-liquid mixture soaked in the low-temperature reaction kettle to 5 ℃ of critical temperature, reducing the pressure to the critical pressure, and reacting for 30-60 minutes to obtain an extraction mixture;
step 6: carrying out solid-liquid separation on the extraction mixture to obtain upper-layer mixed liquid medicine;
and 7: transdermal treatment of mixed medicinal liquid
And (4) adding a transdermal agent into the mixed liquid medicine obtained in the step (6) and mixing to obtain the tumor cancer traditional Chinese medicine.
The invention adopts the principle of low-temperature extraction separation technology, uses vinegar as a solvent in ultralow-temperature extraction, and combines methanol and isopropanol, the freezing point of the vinegar is very low, and pure acetic acid can be frozen below-16 ℃.
The ultra-low temperature extraction strength depends on the temperature and pressure of extraction, the change of temperature affects two factors of the density of extractant and the gas pressure of solute, in the ultra-low temperature region, gas can be converted into liquid when the pressure of gas is continuously increased, when the pressure is increased, the volume of liquid is increased, for a specific substance, a critical pressure (Pc) exists, which is higher than the critical temperature and the critical pressure, the substance can not become liquid or gas, which is the critical point, in the range above the critical point, the substance state is between gas and liquid, the fluid in the range becomes Supercritical Fluid (SF), and the supercritical fluid has stronger penetrating power and larger solubility similar to gas and has good solvent property.
The temperature is reduced and increased to influence the density of the fluid, the solute air pressure is increased and decreased to influence the volume of the material, the volume of the material generates cavitation effect (bubbles) when the machine rotates, the volume of the material acts on the machine and the inner wall, the machine and the inner wall generate reaction force to ensure that the cavitation effect (bubbles) explodes rapidly, the material cells are shredded, effective monomer components are separated out from the fluid extractant, when the temperature is increased to a critical point, the density of the extractant is reduced, the solute air pressure is increased, the volatility is increased, and the extraction rate cannot be reduced but is increased.
The pressure and temperature of the extracting agent fluid are changed, different components in the material are extracted successively according to the solubility in the fluid, substances with weak polarity are extracted firstly under low pressure, substances with larger polarity and large molecular weight and basic properties are extracted in steps under the program lifting and lowering pressure along with the increase and decrease of the pressure, the effect of extracting and separating all components is achieved, the yield of the low-temperature extraction and separation technical method is improved by 15% compared with the traditional yield, and the ultralow-temperature extraction technical method is characterized by being superior in the ultralow-temperature extraction technology.
According to the characteristics of the extraction solvent vinegar, the method has the characteristics of high efficiency, environmental protection, safety, prevention of damage to effective components, retention of the activity of the effective components and the like, and the vinegar is used as the solvent for extraction and has no harm to human bodies, and the technology has importance and prospect.
The invention preferably discloses a preparation method of an external traditional Chinese medicine for resisting tumor and cancer, and the step 1 is to crush the traditional Chinese medicine before soaking.
The invention preferably selects a preparation method of an external traditional Chinese medicine for resisting tumor and cancer, and the specific method for soaking the traditional Chinese medicine comprises the following steps: pulverizing the Chinese medicinal materials, placing into a low-temperature reaction kettle, adding raw stock mature vinegar in an amount of 2-4 times of the mass of the Chinese medicinal materials, sealing the low-temperature reaction kettle, and soaking for more than 20 days.
Further, the mass ratio of the traditional Chinese medicinal materials to the original stock mature vinegar is 1: 3.
The invention preferably discloses a preparation method of an external traditional Chinese medicine for resisting tumor and cancer, and in the step 2, the addition amounts of the methanol and the isopropanol are both 5-7% of the solid-liquid mixture.
Further, the addition amounts of the methanol and the isopropanol were both 6% of the solid-liquid mixture.
The invention preferably selects a preparation method of the external traditional Chinese medicine for resisting tumor and cancer, and in the step 7, the addition amount of the transdermal agent is 2-3% of the mixed liquid medicine.
The invention has the following advantages and beneficial effects:
1. the traditional Chinese medicine composition is prepared by analyzing the reason and the expression of tumor and cancer, is combined with traditional Chinese medicinal materials in a targeted manner, and has the functions of drawing out poison, reducing swelling, resolving masses, removing blood stasis, eliminating tumor, strengthening spleen, nourishing stomach, improving immunity, tonifying kidney, lifting qi and the like.
2. The invention relates to an external traditional Chinese medicine, which is a pure traditional Chinese medicine external preparation directly reaching the diseased region through transdermal absorption, is not absorbed through the stomach, does not hurt the liver, the gallbladder, the spleen and the kidney, does not cause any burden on the intestines and the stomach, and has no toxic or side effect.
3. The medicine has scientific formula, comprehensive efficacy, double effects of strengthening the metabolism function of a human body, bidirectionally regulating humoral immunity and cellular immunity, balancing and enhancing the immune system of the human body, eradicating the pathogenic root of toxin inflammatory factors, enhancing the capability of resisting the invasion of external evil factors such as wind, cold, dampness, heat and the like, and quickly eliminating the symptoms of pain, swelling, stiffness and the like of the affected part.
Not only meets the modern pharmaceutical standard of small amount, high efficiency, safety and controllability provided by the country, but also meets the concept of targeted treatment of tumor by small molecular drugs in clinic.
4. The invention adopts a low-temperature extraction separation technology, has the characteristics of high efficiency, environmental protection, safety, effective component protection from damage, effective component activity retention and the like, vinegar is used as a solvent for extraction and is harmless to human bodies, and the technology has importance and prospect.
5. The medicine of the present invention can be used for the rehabilitation treatment of various cancers such as gastric cancer, esophageal cancer, colon cancer, pancreatic cancer, bladder cancer, breast cancer, lung cancer, uterine tumor, cervical cancer, prostatic hyperplasia, etc.
Has good rehabilitation effect on premenstrual breast distending pain, menstrual breast pain, axillary lymph blocking, hyperplasia of mammary glands, breast nodules, hard masses, pain, acute and chronic mastitis, lobular hyperplasia, mammary gland fibroma, galactocele, hysteromyoma and uterine cyst;
especially has better rehabilitation effect on mastitis, hyperplasia of mammary glands, breast lumps, nodules, mammary gland fibroma, hysteromyoma and ovarian cyst.
Drawings
The accompanying drawings, which are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principles of the invention. In the drawings:
FIG. 1 is a block diagram of the preparation process of the anti-tumor cancer external traditional Chinese medicine of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and accompanying drawings, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not meant to limit the present invention.
First, preparation of medicine
Example 1
1. Preparing traditional Chinese medicine raw materials according to the following weight:
60g of paris polyphylla, 55g of scorpion, 70g of centipede, 50g of ground beetle, 15g of cantharis, 75g of mirabilite, 20g of gecko, 90g of rhizoma alismatis, 60g of poria cocos, 40g of rhizoma atractylodis, 60g of bighead atractylodes rhizome, 65g of subprostrate sophora, 75g of cuckoo-bud, 20g of angelica, 25g of curcuma zedoary, 40g of elecampane, 20g of astragalus membranaceus, 60g of lucid ganoderma, 40g of folium isatidis, 25g of salvia miltiorrhiza, 60g of flos daturae, 30g of angelica sinensis, 70g of radix gentianae macrophyllae, 40g of cotton stalk root, 20g of cortex acanthopanacis, 30g of radix stemonae, 15g of salvia miltiorrhiza, 80g of rhizoma bletillae, 80g of fructus psoraleae, 20g of ginseng, 35g of kansui root, 20g of raw myrrh, 20g of frankincense, 85g of mangnolia officinalis, 90g of herba patriniae, 60g of hypericum, 70g of solanum japonicum, 30g of solanum nigrum, 30g of herba scutellariae barbatae, 30g of longa, 60g of longhairy antenoron herb, 50g of herba hypericum, 85g of longhairy antenoron herb, 60g of longhairy antenoron herb, 50g of longa, 50g of selfheal, 85g of safflower and 30g of dragon's blood.
Wherein the total amount of the Chinese medicinal materials is 44, the total weight is 2.145kg, the addition amount of the original stock mature vinegar is 6.435kg, and the transdermal agent is added according to 2.5% of the weight of the upper layer mixed liquid medicine after solid-liquid separation.
2. The preparation process is shown in figure 1:
step 1: soaking Chinese medicinal materials
Crushing the traditional Chinese medicines, then putting the crushed traditional Chinese medicines into a low-temperature reaction kettle, adding raw stock mature vinegar to soak the traditional Chinese medicines to obtain a solid-liquid mixture, wherein the soaking time is 22 days;
step 2: adding a solvent, wherein the solvent is methanol and isopropanol, and the adding amount of the solvent is 6% of the mass of the solid-liquid mixture;
and step 3: cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-10 ℃, increasing the gas pressure to 0.5MPa, and reacting for 30 minutes;
and 4, step 4: continuously cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-15 ℃, increasing the pressure to 1.5MPa, converting gas into liquid, increasing the volume of the material, and reacting for 40 minutes;
and 5: heating the solid-liquid mixture soaked in the low-temperature reaction kettle to 5 ℃ of critical temperature, reducing the pressure to the critical pressure, and reacting for 40 minutes to obtain an extraction mixture;
step 6: carrying out solid-liquid separation on the extraction mixture and precipitating for 6 hours to obtain upper-layer mixed liquid medicine;
and 7: transdermal treatment of mixed medicinal liquid
Adding a transdermal agent into the mixed liquid medicine obtained in the step 6, stirring for 20 minutes, and uniformly mixing to obtain the tumor cancer traditional Chinese medicine, wherein the transdermal agent is artemisia seed penetrating fluid, and the addition amount of the transdermal agent is 2.5% of the mixed liquid medicine;
and 8: filling according to the specification of 120ml in each bottle;
and step 9: and (6) inspecting, packaging and warehousing.
Example 2
1. Preparing the following raw materials by weight:
50g of paris polyphylla, 50g of scorpion, 60g of centipede, 40g of ground beetle, 10g of cantharis, 70g of mirabilite, 15g of gecko, 80g of rhizoma alismatis, 55g of poria cocos, 35g of rhizoma atractylodis, 55g of bighead atractylodes rhizome, 60g of subprostrate sophora, 70g of cuckoo-bud, 15g of angelica, 20g of curcuma zedoary, 35g of elecampane, 15g of astragalus membranaceus, 55g of lucid ganoderma, 35g of folium isatidis, 20g of salvia miltiorrhiza, 55g of flos daturae, 25g of angelica sinensis, 65g of radix gentianae macrophyllae, 35g of cotton stalk root, 15g of cortex acanthopanacis, 25g of radix stemonae, 10g of salvia miltiorrhiza, 70g of rhizoma bletillae, 70g of fructus psoraleae, 15g of ginseng, 30g of kansui root, 15g of raw myrrh, 15g of frankincense, 80g of mangnolia officinalis, 80g of herba patriniae, 55g of hypericum japonicum, 60g of solanum nigrum, 25g of herba scutellariae barbatae, 25g of longhairy antenoron herb, 55g of longleaf, 55g of longhairy antenoron herb, 25g of longleaf, 55g of longleaf tickclover, 55g of longleaf, 45g of common ivy herb, 55g of selfheal fruit, 80g of selfheal, 25g of safflower and 25g of dragon's.
Wherein the total weight of the Chinese medicinal materials is 1.88kg, the addition amount is 5.64kg, and the transdermal agent is added in an amount of 2.5% of the weight of the upper layer mixed medicinal liquid after solid-liquid separation.
2. The preparation process is shown in figure 1:
step 1: soaking Chinese medicinal materials
Crushing the traditional Chinese medicines, then putting the crushed traditional Chinese medicines into a low-temperature reaction kettle, adding raw stock mature vinegar to soak the traditional Chinese medicines to obtain a solid-liquid mixture, wherein the soaking time is 22 days;
step 2: adding a solvent, wherein the solvent is methanol and isopropanol, and the adding amount of the solvent is 6% of the mass of the solid-liquid mixture;
and step 3: cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-10 ℃, increasing the gas pressure to 0.5MPa, and reacting for 30 minutes;
and 4, step 4: continuously cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-15 ℃, increasing the pressure to 1.5MPa, converting gas into liquid, increasing the volume of the material, and reacting for 40 minutes;
and 5: heating the solid-liquid mixture soaked in the low-temperature reaction kettle to 5 ℃ of critical temperature, reducing the pressure to the critical pressure, and reacting for 40 minutes to obtain an extraction mixture;
step 6: carrying out solid-liquid separation on the extraction mixture and precipitating for 6 hours to obtain upper-layer mixed liquid medicine;
and 7: transdermal treatment of mixed medicinal liquid
Adding a transdermal agent into the mixed liquid medicine obtained in the step 6, stirring for 20 minutes, and uniformly mixing to obtain the tumor cancer traditional Chinese medicine, wherein the transdermal agent is artemisia seed penetrating fluid, and the addition amount of the transdermal agent is 2.5% of the mixed liquid medicine;
and 8: filling according to the specification of 120ml in each bottle;
and step 9: and (6) inspecting, packaging and warehousing.
Example 3
1. Preparing the following raw materials by weight:
70g of paris polyphylla, 60g of scorpion, 80g of centipede, 60g of ground beeltle, 20g of cantharis, 80g of mirabilite, 25g of gecko, 100g of rhizoma alismatis, 65g of poria cocos, 45g of rhizoma atractylodis, 65g of bighead atractylodes rhizome, 70g of subprostrate sophora, 80g of cuckoo-bud, 25g of angelica, 30g of curcuma zedoary, 45g of elecampane, 25g of astragalus membranaceus, 65g of lucid ganoderma, 45g of folium isatidis, 30g of salvia miltiorrhiza, 65g of flos daturae, 35g of angelica sinensis, 75g of actinidia chinensis, 80g of gentiana macrophylla, 45g of cotton stalk root, 25g of cortex acanthopanacis, 35g of radix stemonae, 20g of salvia miltiorrhiza, 90g of rhizoma bletillae, 90g of fructus psoraleae, 25g of ginseng, 40g of kansui root, 25g of raw myrrh, 25g of frankincense, 90g of mangnolia officinalis, 100g of herba patriniae, 65g of hypericum, 80g of solanum japonicum, 80g of solanum nigrum, 35g of herba scutellariae barbatae, 35g of longhairy antenoron, 65g of longhairy antenoron herb, 55g of longleaf, 35g of longleaf, 65g of longleaf glechouliflower, 55g of longleaf tickclover herb, 35g of longleaf, 65g of longleaf tickclover herb, 65g of longleaf, 55g of selfheal, 90g of dragon's, 35g of dragon's, and 35g of dragon's blood.
Wherein the total weight of the Chinese medicinal materials is 2.41kg, the addition amount is 7.23kg, and the transdermal agent is added in an amount of 2.5% of the weight of the upper layer liquid medicine after solid-liquid separation.
2. The preparation process is shown in figure 1:
step 1: soaking Chinese medicinal materials
Crushing the traditional Chinese medicines, then putting the crushed traditional Chinese medicines into a low-temperature reaction kettle, adding raw stock mature vinegar to soak the traditional Chinese medicines to obtain a solid-liquid mixture, wherein the soaking time is 22 days;
step 2: adding a solvent, wherein the solvent is methanol and isopropanol, and the adding amount of the solvent is 6% of the mass of the solid-liquid mixture;
and step 3: cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-10 ℃, increasing the gas pressure to 0.5MPa, and reacting for 30 minutes;
and 4, step 4: continuously cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-15 ℃, increasing the pressure to 1.5MPa, converting gas into liquid, increasing the volume of the material, and reacting for 40 minutes;
and 5: heating the solid-liquid mixture soaked in the low-temperature reaction kettle to 5 ℃ of critical temperature, reducing the pressure to the critical pressure, and reacting for 40 minutes to obtain an extraction mixture;
step 6: carrying out solid-liquid separation on the extraction mixture and precipitating for 6 hours to obtain upper-layer mixed liquid medicine;
and 7: transdermal treatment of mixed medicinal liquid
Adding a transdermal agent into the mixed liquid medicine obtained in the step 6, stirring for 20 minutes, and uniformly mixing to obtain the tumor cancer traditional Chinese medicine, wherein the transdermal agent is artemisia seed penetrating fluid, and the addition amount of the transdermal agent is 2.5% of the mixed liquid medicine;
and 8: filling according to the specification of 120ml in each bottle;
and step 9: and (6) inspecting, packaging and warehousing.
Secondly, the invention is used for the inhibition effect experiment of breast cancer cells
Experimental methods
(1) Collecting breast cancer cells MCF-7 of logarithmic growth phase, and digesting with trypsin to obtain cell suspension with cell sap concentration of about 1 × 105Per liter;
(2) inoculating the cell sap into a 96-well plate, and adding 100ul of the cell sap into each well;
(3) the culture medium containing the Chinese medicine of example 1, the Chinese medicine of example 2, the Chinese medicine of example 3, the cyclophosphamide as a control drug and a solvent control was added to the well plate, and the concentration of the culture medium was controlled to 5g/L, and 100ul was added per well.
(4) After culturing the culture medium at 37 ℃ for 3 days, removing the old culture medium, adding 100ul of MTT culture solution into each well, wherein the concentration of the MTT culture solution is 0.5g/L, continuously culturing for 4 hours at 37 ℃, removing the old culture medium again, adding 100ul of DMSO into each well, and uniformly shaking.
(5) The optical density value was measured with a microplate reader at 570 nm.
(6) Based on the measured values, the survival rate of cancer cells was calculated according to the following formula:
survival (%) (drug O D value/solvent control OD value × 100%.
TABLE 1 Effect of different groups of experimental drugs according to the invention on survival of in vitro breast cancer cells
| Serial number | Experimental groups | Concentration (5g/L) | Survival rate of breast cancer cells |
| 1 | Cyclophosphamide control group | 5 | 28.7％ |
| 2 | Example 1 Chinese medicinal group | 5 | 25.8％ |
| 3 | Example 2 Chinese medicine group | 5 | 27.3％ |
| 4 | Example 3 Chinese medicine group | 5 | 26.4％ |
As can be seen from the above Table 1, the drug of the present invention has a very good inhibitory effect on breast cancer cells in vitro.
Thirdly, the treatment effect of the medicine of the invention on the pain symptoms of patients
60 breast cancer patients are divided into two groups, wherein 30 breast cancer patients are divided into a control group and 30 breast cancer patients are divided into an experimental group, wherein 60 breast cancer patients are female and are classified between 45-60 years old according to the pain degree of the chief complaints, the scoring standard is shown in the following table 2, in order to reduce the pain of the patients, the control group of the experiment adopts tramadol sustained-release tablets for treatment, the experimental group adopts tramadol sustained-release tablets and the external traditional Chinese medicine prepared in the embodiment 1 of the invention to be externally applied to the related acupuncture points and pain parts of the pain parts, the dosage is 3-4 times per day, and the external traditional Chinese medicine is repeatedly applied for 2-3 times after each air drying.
TABLE 2 patient pain scoring criteria
The collected data were analyzed using statistical software SPSS 22.0, and the differences were statistically significant (P < 0.05) as shown in table 3 below.
TABLE 3 pain scoring results before and after treatment for control and experimental groups
| Sample classification | Number of cases | Before treatment | After 3 weeks of treatment | After 6 weeks of treatment | Stopping taking the medicine for 1 week |
| Control group | 30 persons | 4.32±0.35 | 1.83±0.29 | 1.36±0.38 | Onset of pain exacerbation |
| Experimental group | 30 persons | 4.42±0.43 | 2.65±0.33 | 0.32±0.26 | Hardly changes |
| P | — | ＞0.05 | ＜0.05 | ＜0.05 |
From the results, it can be seen that the effect of the pain treatment only by adopting western medicines is inferior to that of the pain treatment by adding the western medicines into the traditional Chinese medicine of the invention, particularly, after the medicine is stopped, the western medicine treatment method cannot cure the root cause, and the external traditional Chinese medicine of the invention can play a role in fundamentally treating the pain, which has a very important significance for cancer patients.
Fourth, the typical clinical experiment of the medicament of the invention
60 breast cancer patients were divided into two groups, 30 in the control group and 30 in the experimental group, 60 of which were female and aged between 45-60 years, and breast cancer tumor sizes were recorded.
The application of the medicine of the invention is then carried out on the experimental group, and the medicine is applied to the cancer area or the corresponding acupuncture points, generally 3-4 times per day.
Statistics shows that the effective rate reaches 98.5 percent after 20-30 times of treatment by using the medicament of the embodiment 1 of the invention.
The clinic for other cancers is as follows:
patient 1: lower limb edema, chest distress and extremely difficult pharynx and food of patients with squamous carcinoma, and gastroscopy result; squamous cancer cells and esophagus are about 28-32 cm from incisor teeth, a nodular lump is seen on the right front wall and protrudes to the cavity, the surface is eroded, becomes brittle and is easy to bleed, the external liquid is applied between the dove tail point and the lower epigastric point, and the nodular lump is obviously reduced after the external liquid for tumor is used for 20 days.
Patient 2: the liquid for external use is difficult to swallow, is fond of drinking water, is stuffy in chest and stomachache, is diagnosed as esophagus cancer in a hospital, has a lump at the 28 cm position of the lower section of the esophagus, and has reduced symptoms and greatly increased appetite after being used for 3 weeks.
Therefore, the external traditional Chinese medicine has the following characteristics: the external liquid for treating the tumor is simple and convenient to use, quick in effect, free of injection and medication, free of wound and pain, exact in curative effect and suitable for various tumors.
The externally applied traditional Chinese medicine for treating the tumor is scientifically matched with the datura flower which is used for treating pain of anesthesia in ancient Huatuo, and the raw myrrh and the raw frankincense, and has strong analgesic effect in cooperation, particularly has the effect of relieving pain of long-term severe pain; can relieve pain caused by various tumors. The product has strong medicine property, safe intervention of medicine effect and no toxic or side effect.
The acupoint pain point administration technology of the externally applied traditional Chinese medicine for treating the tumor directly acts on a focus, continuously acts on cancer cells along meridians and collaterals and blood vessels, and initiates attack on the cancer cells; reducing tumor, controlling tumor growth, reducing compression of tumor on peripheral nerve, promoting penetration of effective components of topical liquid medicine for treating tumor to focus part, and reducing cancer cell diffusion.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. An external traditional Chinese medicine for resisting tumor and cancer is characterized by comprising the following components in parts by weight:
50-70 parts of paris polyphylla, 50-60 parts of scorpion, 60-80 parts of centipede, 40-60 parts of ground beetle, 10-20 parts of cantharis, 70-80 parts of mirabilite, 15-25 parts of gecko, 80-100 parts of rhizoma alismatis, 55-65 parts of poria cocos, 35-45 parts of rhizoma atractylodis, 55-65 parts of bighead atractylodes rhizome, 60-70 parts of subprostrate sophora, 70-80 parts of cuckoo-bud, 15-25 parts of angelica sinensis, 20-30 parts of curcuma zedoary, 35-45 parts of elecampane, 15-25 parts of astragalus membranaceus, 55-65 parts of lucid ganoderma, 35-45 parts of folium isatidis, 20-30 parts of salvia miltiorrhiza, 55-65 parts of flos daturae, 25-35 parts of angelica sinensis, 65-75 parts of radix codonopsis pilosulae, 60-80 parts of gentiana macrophylla, 35-45 parts of cotton stalk root, 15-25 parts of cortex acanthopanacis, 25 parts of radix stemonae, 10-20 parts of salvia miltiorrhiza, 10-20 parts of radix salviae miltiorrhizae, rhizoma pineae, rhizoma pinelliae, and rhizoma pinelliae, etc, 70-90 parts of bletilla, 70-90 parts of fructus psoraleae, 15-25 parts of ginseng, 30-40 parts of euphorbia kansui, 15-25 parts of raw myrrh, 15-25 parts of raw frankincense, 80-90 parts of mangnolia officinalis, 80-100 parts of herba patriniae, 55-65 parts of hypericum japonicum, 60-80 parts of solanum nigrum, 25-35 parts of sculellaria barbata, 25-35 parts of longhairy antenoron herb, 55-65 parts of selfheal, 45-55 parts of semen coicis, 80-90 parts of safflower and 25-35 parts of dragon's blood.
2. The externally applied traditional Chinese medicine for resisting tumor and cancer according to claim 1, which is characterized in that the traditional Chinese medicine comprises the following components in parts by weight:
60 parts of paris polyphylla, 55 parts of scorpion, 70 parts of centipede, 50 parts of ground beetle, 15 parts of cantharis, 75 parts of mirabilite, 20 parts of gecko, 90 parts of rhizoma alismatis, 60 parts of poria cocos, 40 parts of rhizoma atractylodis, 60 parts of bighead atractylodes rhizome, 65 parts of subprostrate sophora, 75 parts of buttercup root, 20 parts of angelica, 25 parts of curcuma zedoary, 40 parts of elecampane, 20 parts of astragalus membranaceus, 60 parts of lucid ganoderma, 40 parts of folium isatidis, 25 parts of salvia miltiorrhiza, 60 parts of lonicera japonica, 30 parts of angelica sinensis, 70 parts of radix gentianae macrophyllae, 40 parts of cotton stalk root, 20 parts of cortex acanthopanacis, 30 parts of radix stemonae, 15 parts of salvia miltiorrhiza, 80 parts of rhizoma bletillae, 80 parts of fructus psoraleae, 20 parts of ginseng, 35 parts of kansui root, 20 parts of raw myrrh, 85 parts of raw frankincense, 85 parts of mangnolia officinalis, 90 parts of herba patriniae, 60 parts of hypericum japonicum, 70 parts of solanum nigrum, 30 parts of herba scutellariae barbatae, 30 parts of herba hypericum, 60 parts of longa, 30 parts of longhairy antenoron, 60 parts of longa, 50 parts of herba hypericum, 85 parts of herba hypericum, 30 parts of herba hypericum, 50 parts of herba hypericum japonicum, 50 parts of selfheal, 85 parts of safflower and 30 parts of dragon's.
3. The externally applied traditional Chinese medicine for resisting tumor and cancer according to claim 1, further comprising protoplasm mature vinegar, wherein the mass ratio of the protoplasm mature vinegar to the traditional Chinese medicine is 2: 1-4: 1.
4. the topical Chinese medicine for the treatment of tumor and cancer according to claim 1 or 2, further comprising transdermal agent.
5. The external traditional Chinese medicine for resisting tumor and cancer according to claim 1 or 2, wherein the medicine is prepared into liquid, paste or patch.
6. A preparation method of an external traditional Chinese medicine for resisting tumor and cancer is characterized by comprising the following steps:
step 1: soaking Chinese medicinal materials
Soaking the traditional Chinese medicinal materials of any one of claims 1-5 in a low-temperature reaction kettle by using original stock mature vinegar to obtain a solid-liquid mixture;
step 2: adding a solvent, wherein the solvent is methanol and isopropanol;
and step 3: cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-8 to-12 ℃, increasing the gas pressure to 0.3 to 0.6MPa, and reacting for at least 20 minutes;
and 4, step 4: continuously cooling the solid-liquid mixture soaked in the low-temperature reaction kettle to-13 to-16 ℃, increasing the pressure to 1.3 to 1.6MPa, converting gas into liquid, increasing the volume of the material, and reacting for at least 30 minutes;
and 5: heating the solid-liquid mixture soaked in the low-temperature reaction kettle to 5 ℃ of critical temperature, reducing the pressure to the critical pressure, and reacting for 30-60 minutes to obtain an extraction mixture;
step 6: carrying out solid-liquid separation on the extraction mixture to obtain upper-layer mixed liquid medicine;
and 7: transdermal treatment of mixed medicinal liquid
And (4) adding a transdermal agent into the mixed liquid medicine obtained in the step (6) and mixing to obtain the tumor cancer traditional Chinese medicine.
7. The method for preparing an externally-applied traditional Chinese medicine for resisting tumor and cancer according to claim 6, wherein the step 1 is to pulverize the traditional Chinese medicine before soaking.
8. The preparation method of the externally applied traditional Chinese medicine for resisting tumor and cancer according to claim 6 or 7, wherein the specific method for soaking the traditional Chinese medicine is as follows: pulverizing the Chinese medicinal materials, placing into a low-temperature reaction kettle, adding raw stock mature vinegar in an amount of 2-4 times of the mass of the Chinese medicinal materials, sealing the low-temperature reaction kettle, and soaking for more than 20 days.
9. The method for preparing the externally applied traditional Chinese medicine for treating tumor and cancer according to claim 6 or 7, wherein in the step 2, the addition amount of the methanol and the isopropanol is 5-7% of the solid-liquid mixture.
10. The method for preparing an external traditional Chinese medicine for resisting tumor and cancer according to claim 6 or 7, wherein in the step 7, the addition amount of the transdermal agent is 2-3% of the mixed liquid medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111304670.9A CN114288372A (en) | 2021-11-05 | 2021-11-05 | A topical Chinese medicinal composition for treating tumor and cancer, and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111304670.9A CN114288372A (en) | 2021-11-05 | 2021-11-05 | A topical Chinese medicinal composition for treating tumor and cancer, and its preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114288372A true CN114288372A (en) | 2022-04-08 |
Family
ID=80964227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111304670.9A Pending CN114288372A (en) | 2021-11-05 | 2021-11-05 | A topical Chinese medicinal composition for treating tumor and cancer, and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114288372A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194144A (en) * | 1997-03-21 | 1998-09-30 | 职素琴 | External use ointment for curing cancer and its producing method |
| CN106729407A (en) * | 2016-12-27 | 2017-05-31 | 四川西奈生物科技有限公司 | The Chinese medicine composition for the treatment of cancer |
| CN110354184A (en) * | 2019-04-26 | 2019-10-22 | 郴州天之予健康管理股份有限公司 | The external drug and preparation method thereof for treating women cervical carcinoma |
-
2021
- 2021-11-05 CN CN202111304670.9A patent/CN114288372A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1194144A (en) * | 1997-03-21 | 1998-09-30 | 职素琴 | External use ointment for curing cancer and its producing method |
| CN106729407A (en) * | 2016-12-27 | 2017-05-31 | 四川西奈生物科技有限公司 | The Chinese medicine composition for the treatment of cancer |
| CN110354184A (en) * | 2019-04-26 | 2019-10-22 | 郴州天之予健康管理股份有限公司 | The external drug and preparation method thereof for treating women cervical carcinoma |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101181529B (en) | Chinese medicine composition for curing tumor and preparation method thereof | |
| CN104491759B (en) | A kind of Chinese medicine composition for treating antimigraine and preparation method thereof | |
| CN101569739B (en) | Traditional Chinese medicine composition for treating cholecystitis and preparation method thereof | |
| CN111110759A (en) | Water-eliminating ointment for treating cancerous ascites and preparation method thereof | |
| CN103263531A (en) | Chinese medicine composition for treating prosopalgia and preparation method thereof | |
| CN101417067B (en) | Medicine combination with anti-tumor function | |
| CN1067555C (en) | Application of medicinal combination containing termite population and main nest bacterial nursery | |
| CN104056242A (en) | Traditional Chinese medicine composition for treating acute cholecystitis and preparation method thereof | |
| CN114288372A (en) | A topical Chinese medicinal composition for treating tumor and cancer, and its preparation method | |
| CN104258260B (en) | A kind of saline cistanche alcohol extracting thing, preparation method and its usage | |
| CN101810667A (en) | Medicine composition for auxiliary treatment of cancer | |
| CN103735710B (en) | Traditional Chinese medicine composition for treating recessive mastitis of dairy cows and preparation method thereof | |
| CN108186921B (en) | An antitumor selenium-containing Chinese medicinal composition and its preparation method | |
| CN112274598A (en) | Medicine for treating liver cancer and preparation method thereof | |
| CN108355052B (en) | Medicine for treating leucopenia after radiotherapy and chemotherapy and preparation method and application thereof | |
| CN105031550A (en) | Novel traditional Chinese medicine formula for tumor treatment containing scorpion venom macromolecules | |
| CN112494614A (en) | Chinese medicinal formula for preventing and treating cancer by using combination of pawpaw and various medicines | |
| CN104623532A (en) | Traditional Chinese medicine composition for treating glioma and preparation method thereof | |
| CN107468938A (en) | A kind of formula of asparagus tea and preparation method thereof | |
| CN114588240B (en) | Traditional Chinese medicine composition for treating colorectal cancer and preparation method and application thereof | |
| CN103610991B (en) | Medicine being used for the treatment of swine gastric ulcer and preparation method thereof | |
| CN116603033B (en) | Traditional Chinese medicine tablet for clearing heat and detoxicating and preparation method thereof | |
| CN106344655A (en) | Traditional Chinese medicinal composition with blood glucose reducing effect and manufacturing method thereof | |
| CN104840826A (en) | Traditional Chinese medicine preparation for treating aspiration site infection caused by bone marrow aspiration and preparation method thereof | |
| CN105661054A (en) | Feed additive for sheep of 2-12 months old and preparation method of feed additive |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220408 |