CN105250993A - Composition for local burn - Google Patents
Composition for local burn Download PDFInfo
- Publication number
- CN105250993A CN105250993A CN201510817963.5A CN201510817963A CN105250993A CN 105250993 A CN105250993 A CN 105250993A CN 201510817963 A CN201510817963 A CN 201510817963A CN 105250993 A CN105250993 A CN 105250993A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- compositions
- growth factor
- recombinant human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of traditional Chinese medicines and in particular relates to a composition for local burn. The composition is prepared from the following raw materials in parts by weight: 10-18 parts of benzoin, 20-30 parts of lanatechead saussurea herb with flower, 18-28 parts of Japanese Ardisia Herb, 10-20 parts of herba siegesbeckiae, 25-35 parts of kadsura pepper stem, 9-18 parts of oven earth, 10-22 parts of Aizoon Stonecrop Herb, 17-26 parts of baked ginger, 10-22 parts of hydrargyrum oxydatum crudum, 15-30 parts of Chinese Azalea Flower, 10-18 parts of raw polygonum multiflorum and 0.0002-0.0008 part of recombinant human epidermal growth factor. The composition for treating local burn disclosed by the invention has the effects of regenerating tissue to heal wound, cooling the blood to stop bleeding, clearing away heat and toxic materials, resisting bacteria and diminishing inflammation and promoting wound healing; and moreover, the scar can be removed, the course of treatment is short, and the activity can be maintained for a long time.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of compositions for topical burn.
Background technology
Burn and refer to by heating power and action of chemicals after human body, to the damage that the local organization of human body causes.Heating power wherein comprises burn and scald, cold injury and electricity wound etc.Western medical treatment is burnt and main is adopted hydrogen peroxide debridement and through liquid medicine disinfecting hemostasis, and the sterilizing objects such as iodine tincture, takes antibiotic medicine in also needing simultaneously.But, can not mercurochrome be used when the wound of burning is darker, and red tribute can not use with iodine, easily make human body generation iodate tribute poisoning.
Chinese traditional treatment is burnt and is usually used water solublity Chinese medicine preparation, and disclosed in No. 1583027A, Chinese patent, name is called that in " trauma hemostasis granulation promoting Chinese medicine powder ", proposition adopts pearl sand grass meal end, the mixing of Herba Chenopodii Hybridi powder, chinese Pulsatilla Root, Herba Erodii powder and borneol powder is mixed with a kind of liniment.Herba Chenopodii Hybridi in this Chinese medicine powder has treating blood disorders cooling blood for hemostasis effect, and the Radix Pulsatillae has heat-clearing and toxic substances removing, removing heat from blood effect, and Borneolum Syntheticum can clearing away heat to alleviate pain.Although this Chinese medicine powder can stop blooding to a certain extent, the effect such as heat-clearing and toxic substances removing and pain relieving, can it lacks raw myofunctional medicine, need to inquire into further for close trauma wound.
Ling Shadan abides by ancient big gun to process and clarify saturated colloid solution, Main Ingredients and Appearance with the sepia using modern science technique to extract: Rhizoma Smilacis Glabrae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Flos Lonicerae, Fructus Forsythiae, Flos Carthami, Radix Arnebiae (Radix Lithospermi), Olibanum, Myrrha, Radix Angelicae Sinensis, the Radix Astragali, the Radix Angelicae Dahuricae, Pheretima, Borneolum Syntheticum etc.Although this kind of Chinese medicine, without hormone, has no side effect, there is good anti-inflammation, wound healing effect, but with regard to the wound of burning, even if there is no external used medicine, also can clear-cutting forestland as long as no inflammation, main problem easily occurs cicatrix in wound site.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions for topical burn, said composition promoting tissue regeneration and ulcer healing, cooling blood for hemostasis, heat-clearing and toxic substances removing, anti-inflammation, wound healing, and can remove cicatrix, short treating period.
For achieving the above object, the present invention adopts following technical scheme:
For a compositions for topical burn, be made up of the raw material of following weight portion: Benzoinum 10 ~ 18 parts, Herba Saussureae Involueratae 20 ~ 30 parts, Herba Ardisiae Japonicae 18 ~ 28 parts, Herba Siegesbeckiae 10 ~ 20 parts, Caulis Piperis Kadsurae 25 ~ 35 parts, humus flava usta 9 ~ 18 parts, Herba Sedi Aizoon 10 ~ 22 parts, Rhizoma Zingiberis Preparatum 17 ~ 26 parts, Hydrargyri Oxydum Rubrum 10 ~ 22 parts, Flos Rhododendri Mollis 15 ~ 30 parts, Radix Polygoni Multiflori 10 ~ 18 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
Preferably, the compositions for topical burn of the present invention, is made up of the raw material of following weight portion: Benzoinum 12 ~ 16 parts, Herba Saussureae Involueratae 23 ~ 27 parts, Herba Ardisiae Japonicae 21 ~ 25 parts, Herba Siegesbeckiae 13 ~ 17 parts, Caulis Piperis Kadsurae 28 ~ 32 parts, humus flava usta 11 ~ 15 parts, Herba Sedi Aizoon 14 ~ 18 parts, Rhizoma Zingiberis Preparatum 19 ~ 23 parts, Hydrargyri Oxydum Rubrum 12 ~ 20 parts, Flos Rhododendri Mollis 20 ~ 25 parts, Radix Polygoni Multiflori 12 ~ 16 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
More preferably, the compositions for topical burn of the present invention, is made up of the raw material of following weight portion: Benzoinum 14 parts, Herba Saussureae Involueratae 25 parts, Herba Ardisiae Japonicae 23 parts, Herba Siegesbeckiae 15 parts, Caulis Piperis Kadsurae 30 parts, humus flava usta 13 parts, Herba Sedi Aizoon 16 parts, Rhizoma Zingiberis Preparatum 21 parts, Hydrargyri Oxydum Rubrum 16 parts, Flos Rhododendri Mollis 23 parts, Radix Polygoni Multiflori 14 parts, recombinant human epidermal growth factor 0.0005 part.
In raw material of the present invention, Benzoinum is had one's ideas straightened out refreshment, and eliminating the phlegm, it is dirty to ward off, promoting flow of QI and blood, pain relieving; Herba Ardisiae Japonicae relieving cough and asthma, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling; Herba Saussureae Involueratae wind-damp dispelling, bone and muscle strengthening, the kidney warming sun, promoting blood circulation to restore menstrual flow; Herba Siegesbeckiae expelling wind and removing dampness, dredge the meridian passage, heat-clearing and toxic substances removing; Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging; Herba Sedi Aizoon removing stasis to stop bleeding, reducing swelling and alleviating pain, mind tranquilizing and the heart calming; Rhizoma Zingiberis Preparatum warming the meridian for stopping bleeding, warming middle-JIAO to relieve pain, warming middle-JIAO to stop diarrhea; Humus flava usta warming middle-JIAO stops blooding, and stomach warming preventing or arresting vomiting is warming spleen and stopping diarrha; Flos Rhododendri Mollis expelling wind and removing dampness, dissipating blood stasis analgesic therapy; Drawing out pus by applying a plaster to the affected part of Hydrargyri Oxydum Rubrum is rotten, promoting tissue regeneration and ulcer healing; Radix Polygoni Multiflori cuts cruel, removing toxic substances, loosening bowel to relieve constipation; Recombinant human epidermal growth factor hemostasis and pain-relieving, removing toxic substances and promoting subsidence of swelling, promotion tissue regeneration, tool reparation and organize nascent capacity, can high efficiency anti-inflammatory, promote cytothesis and tissue newborn, impel the growth fast of the tissues such as muscle, epidermis, muscle arteries and veins, blood vessel, without cicatrix more.
Beneficial effect of the present invention is:
1, Benzoinum of the present invention, Herba Saussureae Involueratae, Herba Ardisiae Japonicae, Herba Siegesbeckiae, Caulis Piperis Kadsurae, humus flava usta, Herba Sedi Aizoon, Rhizoma Zingiberis Preparatum, Hydrargyri Oxydum Rubrum, Flos Rhododendri Mollis, Radix Polygoni Multiflori and recombinant human epidermal growth factor reasonable compatibility, play promoting tissue regeneration and ulcer healing altogether, cooling blood for hemostasis, heat-clearing and toxic substances removing, anti-inflammation, promote local woanded surface healing, and cicatrix effect can be gone.
2, compositions of the present invention has immunoregulation effect, can strengthen liver and gall cell autoimmunity function, and opposing poisoning intrusion, also can improve body non-specific immunity, increases the generation of antibody, has analgesic effect simultaneously, alleviates patient's misery.
3, recombinant human epidermal growth factor of the present invention can promote the synthesis of DNA, RNA and hydroxyproline in skin wound process of tissue reparation, the epidermis cell of differentiation-inducing maturation reverses and turns to epidermal stem cells, accelerate the generation of wound granulation tissue and epithelial propagation, thus shorten the healing time of wound surface, improve wound repair quality, there are soft skin, slow down aging, reduce the effect of wound surface cicatrization.
4, compositions of the present invention effectively can treat local burn and scald, cold injury, electricity wound, chemical substance burns, short treating period, no pain, and does not leave over any cicatrix or hyaline thrombus.
5, Benzoinum of the present invention, Herba Saussureae Involueratae, Herba Ardisiae Japonicae, Herba Siegesbeckiae, Caulis Piperis Kadsurae, humus flava usta, Herba Sedi Aizoon, Rhizoma Zingiberis Preparatum, Hydrargyri Oxydum Rubrum, Flos Rhododendri Mollis, Radix Polygoni Multiflori and recombinant human epidermal growth factor reasonable compatibility, the activity of recombinant human epidermal growth factor can be kept, recombinant human epidermal growth factor can also be helped to go deep into deep skin fast, improve drug effect, remarkable accelerated wound healing.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
For a compositions for topical burn, be made up of the raw material of following weight portion: Benzoinum 18 parts, Herba Saussureae Involueratae 30 parts, Herba Ardisiae Japonicae 18 parts, Herba Siegesbeckiae 20 parts, Caulis Piperis Kadsurae 25 parts, humus flava usta 18 parts, Herba Sedi Aizoon 10 parts, Rhizoma Zingiberis Preparatum 26 parts, Hydrargyri Oxydum Rubrum 10 parts, Flos Rhododendri Mollis 30 parts, Radix Polygoni Multiflori 10 parts, recombinant human epidermal growth factor 0.0008 part.
The preparation method of the described compositions for topical burn is as follows:
1) by Benzoinum, Herba Saussureae Involueratae, Herba Ardisiae Japonicae, Herba Siegesbeckiae, Caulis Piperis Kadsurae, humus flava usta, Herba Sedi Aizoon, Rhizoma Zingiberis Preparatum, Hydrargyri Oxydum Rubrum, Flos Rhododendri Mollis and Radix Polygoni Multiflori, 100 orders are crushed to;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 12 times of volumetric concentrations is the alcoholic solution of 60%, is forced into 4kgf/cm
2, make its pressure uniform, and keep 3min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 1.5h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, being concentrated into relative density is 1.1, obtains paste;
5) paste is mixed homogeneously with recombinant human epidermal growth factor.
Embodiment 2
For a compositions for topical burn, be made up of the raw material of following weight portion: Benzoinum 12 parts, Herba Saussureae Involueratae 27 parts, Herba Ardisiae Japonicae 21 parts, Herba Siegesbeckiae 17 parts, Caulis Piperis Kadsurae 28 parts, humus flava usta 15 parts, Herba Sedi Aizoon 14 parts, Rhizoma Zingiberis Preparatum 23 parts, Hydrargyri Oxydum Rubrum 12 parts, Flos Rhododendri Mollis 25 parts, Radix Polygoni Multiflori 12 parts, recombinant human epidermal growth factor 0.0006 part.
Preparation method is identical with claim 1.
Embodiment 3
For a compositions for topical burn, be made up of the raw material of following weight portion: Benzoinum 14 parts, Herba Saussureae Involueratae 25 parts, Herba Ardisiae Japonicae 23 parts, Herba Siegesbeckiae 15 parts, Caulis Piperis Kadsurae 30 parts, humus flava usta 13 parts, Herba Sedi Aizoon 16 parts, Rhizoma Zingiberis Preparatum 21 parts, Hydrargyri Oxydum Rubrum 16 parts, Flos Rhododendri Mollis 23 parts, Radix Polygoni Multiflori 14 parts, recombinant human epidermal growth factor 0.0005 part.
Preparation method is identical with claim 1.
Embodiment 4
For a compositions for topical burn, be made up of the raw material of following weight portion: Benzoinum 16 parts, Herba Saussureae Involueratae 23 parts, Herba Ardisiae Japonicae 25 parts, Herba Siegesbeckiae 13 parts, Caulis Piperis Kadsurae 32 parts, humus flava usta 11 parts, Herba Sedi Aizoon 18 parts, Rhizoma Zingiberis Preparatum 19 parts, Hydrargyri Oxydum Rubrum 20 parts, Flos Rhododendri Mollis 20 parts, Radix Polygoni Multiflori 16 parts, recombinant human epidermal growth factor 0.0004 part.
Preparation method is identical with claim 1.
Embodiment 5
For a compositions for topical burn, be made up of the raw material of following weight portion: Benzoinum 10 parts, Herba Saussureae Involueratae 30 parts, Herba Ardisiae Japonicae 28 parts, Herba Siegesbeckiae 10 parts, Caulis Piperis Kadsurae 35 parts, humus flava usta 9 parts, Herba Sedi Aizoon 22 parts, Rhizoma Zingiberis Preparatum 17 parts, Hydrargyri Oxydum Rubrum 22 parts, Flos Rhododendri Mollis 15 parts, Radix Polygoni Multiflori 18 parts, recombinant human epidermal growth factor 0.0002 part.
Preparation method is identical with claim 1.
Test example 1
Carried out testing experiment to localized burn, scald, cold injury, electricity wound and chemical substance burn patients respectively by the compositions for topical burn of embodiment 1 ~ 5, testing program is as follows:
Every 4 hours of every day used once, or used as required, until use to wound healing, observed result of use.
Using method for the compositions of topical burn: get appropriate compositions, is directly applied to wound face or compositions is placed in right amount on clean finger or cotton swab, being applied to wound face.
Clinical treatment testing result is in table 1, as follows:
Table 1 embodiment of the present invention 1 ~ 5 treats topical burn clinical treatment testing result
Test example 2: the compositions active testing data for topical burn of the present invention
The compositions being used for topical burn of the present invention's 5 embodiments is regularly carried out active testing, obtains the result as following table 2:
The table 2 compositions active testing data for topical burn of the present invention
As can be seen from data above, the compositions activity-maintaining time for topical burn of the present invention is permanent, and lasting rate at least can reach 3 years.
Claims (3)
1. for a compositions for topical burn, it is characterized in that, be made up of the raw material of following weight portion: Benzoinum 10 ~ 18 parts, Herba Saussureae Involueratae 20 ~ 30 parts, Herba Ardisiae Japonicae 18 ~ 28 parts, Herba Siegesbeckiae 10 ~ 20 parts, Caulis Piperis Kadsurae 25 ~ 35 parts, humus flava usta 9 ~ 18 parts, Herba Sedi Aizoon 10 ~ 22 parts, Rhizoma Zingiberis Preparatum 17 ~ 26 parts, Hydrargyri Oxydum Rubrum 10 ~ 22 parts, Flos Rhododendri Mollis 15 ~ 30 parts, Radix Polygoni Multiflori 10 ~ 18 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
2. the compositions for topical burn according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Benzoinum 12 ~ 16 parts, Herba Saussureae Involueratae 23 ~ 27 parts, Herba Ardisiae Japonicae 21 ~ 25 parts, Herba Siegesbeckiae 13 ~ 17 parts, Caulis Piperis Kadsurae 28 ~ 32 parts, humus flava usta 11 ~ 15 parts, Herba Sedi Aizoon 14 ~ 18 parts, Rhizoma Zingiberis Preparatum 19 ~ 23 parts, Hydrargyri Oxydum Rubrum 12 ~ 20 parts, Flos Rhododendri Mollis 20 ~ 25 parts, Radix Polygoni Multiflori 12 ~ 16 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
3. the compositions for topical burn according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Benzoinum 14 parts, Herba Saussureae Involueratae 25 parts, Herba Ardisiae Japonicae 23 parts, Herba Siegesbeckiae 15 parts, Caulis Piperis Kadsurae 30 parts, humus flava usta 13 parts, Herba Sedi Aizoon 16 parts, Rhizoma Zingiberis Preparatum 21 parts, Hydrargyri Oxydum Rubrum 16 parts, Flos Rhododendri Mollis 23 parts, Radix Polygoni Multiflori 14 parts, recombinant human epidermal growth factor 0.0005 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510817963.5A CN105250993A (en) | 2015-11-23 | 2015-11-23 | Composition for local burn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510817963.5A CN105250993A (en) | 2015-11-23 | 2015-11-23 | Composition for local burn |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105250993A true CN105250993A (en) | 2016-01-20 |
Family
ID=55091118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510817963.5A Pending CN105250993A (en) | 2015-11-23 | 2015-11-23 | Composition for local burn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105250993A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878605A (en) * | 2016-06-14 | 2016-08-24 | 四川宇禾医药投资管理有限公司 | Preparation method of compound saussurea involucrate burn and scald ointment |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085445A (en) * | 1993-07-29 | 1994-04-20 | 谢红波 | Chinese herbal medicine scald medicine and its preparation method |
| CN1660442A (en) * | 2004-12-29 | 2005-08-31 | 中国海洋大学 | Transmission system for medicine containing trehalose and hyaluronic acid in use for curing burn and preparing method |
| CN101920005A (en) * | 2010-05-20 | 2010-12-22 | 江其生 | Novel skin radiation injury protective agent |
| CN104940909A (en) * | 2015-06-30 | 2015-09-30 | 桂林华诺威基因药业有限公司 | Unguent for treating empyrosis and preparation method thereof |
-
2015
- 2015-11-23 CN CN201510817963.5A patent/CN105250993A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1085445A (en) * | 1993-07-29 | 1994-04-20 | 谢红波 | Chinese herbal medicine scald medicine and its preparation method |
| CN1660442A (en) * | 2004-12-29 | 2005-08-31 | 中国海洋大学 | Transmission system for medicine containing trehalose and hyaluronic acid in use for curing burn and preparing method |
| CN101920005A (en) * | 2010-05-20 | 2010-12-22 | 江其生 | Novel skin radiation injury protective agent |
| CN104940909A (en) * | 2015-06-30 | 2015-09-30 | 桂林华诺威基因药业有限公司 | Unguent for treating empyrosis and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105878605A (en) * | 2016-06-14 | 2016-08-24 | 四川宇禾医药投资管理有限公司 | Preparation method of compound saussurea involucrate burn and scald ointment |
| CN105878605B (en) * | 2016-06-14 | 2019-10-11 | 四川宇禾医药投资管理有限公司 | The production method of compound saussurea involucrata salve for treating burn and scald |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102488869B (en) | Traditional Chinese medicinal external-use liniment for muscle and bone ache | |
| CN101623410B (en) | Ointment for treating rheumatism, cold arthralgia and traumatic injury | |
| CN106581439A (en) | Traditional Chinese medicine composition for treating wounds, diabetic feet and skin ulceration, and preparation method thereof | |
| CN1531950A (en) | Plaster medicine composition with multiple purpose for treating affection pain due to dampness | |
| CN107007714A (en) | It is a kind of that there is the exterior-applied medical wine for promoting poroma nucleus formation | |
| CN105055798A (en) | Chinese medicine preparation capable of treating stretch marks and preparing method of Chinese medicine preparation | |
| CN105250993A (en) | Composition for local burn | |
| CN102389483B (en) | Scald ointment | |
| CN1284580C (en) | Bone Activating stasis transforming capsule | |
| CN103223078A (en) | Traditional Chinese medicine used for treating knee osteoarthritis through iontophoresis | |
| CN105853866A (en) | Method for preparing Chinese herbal medicine composition for treating bedsore | |
| CN102204977B (en) | Preparation method and application of ointment composition for external use for treating tubal nowhere | |
| CN105748619B (en) | Medicine for treating plasma cell mastitis and preparation method thereof | |
| CN101732567B (en) | Medicament for treating burns and preparation method thereof | |
| CN101461933A (en) | Medicinal liquor for treating traumatic injury as well as neck, shoulder and lumbocrural pain | |
| CN110538272A (en) | swelling-reducing and collateral-dredging powder for treating soft tissue injury and joint swelling and pain and preparation method thereof | |
| CN105233269A (en) | Medicine compound treating local burns | |
| CN105233268A (en) | External use ointment treating local burns | |
| CN103520662A (en) | Traditional Chinese medicine formula for treating ankylosing spondylitis | |
| CN1292771C (en) | Skin injury treating Chinese traditional medicine | |
| CN102895471B (en) | Medicine for treatment of acne, folliculitis and pustular herpes and preparation method thereof | |
| CN1069046C (en) | Liniment for treating bony spur | |
| CN1879713A (en) | A liniment for treating facial acne and preparation method thereof | |
| CN1504217A (en) | External use liquid formulation for dermatosis | |
| CN105193996A (en) | Traditional Chinese medicine composition for treating decubitus and preparation method of traditional Chinese medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160120 |
|
| RJ01 | Rejection of invention patent application after publication |