CN105878605A - Preparation method of compound saussurea involucrate burn and scald ointment - Google Patents
Preparation method of compound saussurea involucrate burn and scald ointment Download PDFInfo
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Abstract
The invention discloses a preparation method of a compound saussurea involucrate burn and scald ointment. The preparation method comprises the following steps that 120-140 g of saussurea involucrata flowers, 90-110 g of radix arnebiae seu lithospermi, 0.4-0.5 g of stigma croci, 1.0-1.6 g of bear gall powder, 0.2-0.4 g of musk and 35-40 g of borneol are taken; stigma croci, the bear gall powder, musk and borneol are crushed into fine powder and then screened; saussurea involucrata flowers are decocted twice by adding water, filtering is conducted to obtain saussurea involucrata flower filtrate, the saussurea involucrata flower filtrate is concentrated into thick paste, the thick paste is dried to obtain saussurea involucrata flower dry extract powder, and the saussurea involucrata flower dry extract powder and the fine powder are mixed to be uniform and then screened; 1,000 g of sesame oil is taken, radix arnebiae seu lithospermi is immersed into the sesame oil, and impregnating under heat preservation is conducted to obtain radix arnebiae seu lithospermi oil; bee wax is taken according to the proportion that 1.2-1.5 g of the bee wax is taken for every 10 g of the radix arnebiae seu lithospermi oil, the bee wax is heated to be melt and then uniformly mixed with the radix arnebiae seu lithospermi oil, the fine powder is added into the materials, uniform stirring and filling are conducted, and then the compound saussurea involucrate burn and scald ointment is obtained. The preparation method is short in cycle and simple in process and can be applied to industrialized production.
Description
Technical field
The present invention relates to the manufacture method of a kind of Scald Ointment, be specifically related to a kind of compound saussurea involucrata salve for treating burn and scald
Manufacture method.
Background technology
Domestic pharmacopeia ointment dosage form mainly has two big classes: one, finely ground for medicine essence and substrate is mixed together.
Its two, by medicine dissolution in substrate.CN1139571 discloses a kind of Herba Saussureae Involueratae Scald Ointment, this Scald Ointment by
Following several components composition, Herba Saussureae Involueratae 900～～1100 parts, Stigma Croci 4.5～～5.5 parts, Radix Arnebiae (Radix Lithospermi) 90～～
110 parts, Fel Ursi 4.5～～5.5 parts, artificial Moschus 0.45～～0.55 part, Borneolum Syntheticum 90～～110 parts, sesame
Oleum Sesami 1350～～1650 parts, white vaseline 450～～550 parts.Above-mentioned patent also discloses Herba Saussureae Involueratae scald
The manufacture method hindering cream is as follows: weighs Fel Ursi 5g, artificial Moschus 0.5g, Borneolum Syntheticum 100g, they is finely ground into
Powder, by No. 8 sieves, then by No. 9 sieves, it is desirable to by the powder of No. 9 sieves no less than 90%；By medicine
Thing main component Herba Saussureae Involueratae 1000g, Stigma Croci 5g, Radix Arnebiae (Radix Lithospermi) 100g Oleum sesami soak about 48 hours, then
With stone grinder, medicine is finely ground into pasty state, standby by crocus cloth filtered several times；By box-packed for above-mentioned levigate pasty state use watt
Good, standby with slow fire boiling ointment；Substrate white vaseline 500g is had at melted at melting point, Medium Culture
Solid impurity is standby by crocus cloth filtered several times while hot；Ointment is melted at fusing point, adds substrate Bai Fanshi
Woods and above-mentioned fine powder are heated and are stirred evenly；By cream refining dress, seal.It is white at above-mentioned Herba Saussureae Involueratae Scald Ointment mesostroma
Vaseline, Herba Saussureae Involueratae, Stigma Croci use Oleum Sesami to soak together with Radix Arnebiae (Radix Lithospermi), artificial Moschus is natural artificial Moschus.
This product, with the presence of substantial amounts of oils and fats, uses white vaseline as ointment base, and white vaseline consumption is big, ointment
Mastic molding effect is poor, uses Cera Flava as ointment base, and Cera Flava consumption is little, ointment mastic good forming effect.
And Cera Flava has certain pharmacological action: removing toxic substances, sore, granulation promoting, pain relieving.Outer for ulcer being unable to heal, ecthyma
Erosion, wound ulceration, burn and scald.
Summary of the invention
It is an object of the invention to provide one and be beneficial to cure wound surface, easy to use, evident in efficacy specially controls burn and scald
The manufacture method of the compound saussurea involucrata salve for treating burn and scald of wound.
In order to reach above-mentioned technique effect, the present invention takes techniques below scheme:
The manufacture method of a kind of compound saussurea involucrata salve for treating burn and scald, comprises the following steps:
Step A: take Herba Saussureae Involueratae 120～140g, Radix Arnebiae (Radix Lithospermi) 90～110g, Stigma Croci 0.4～0.5g, Fel Ursi powder
1.0～1.6g, Moschus 0.2～0.4g, Borneolum Syntheticum 35～40g；
Step B: Stigma Croci, Fel Ursi powder, Moschus, Borneolum Syntheticum powder are broken into fine powder, sieve；
Step C: Herba Saussureae Involueratae boiling twice, decocts 1 hour, collecting decoction every time, filters to obtain Herba Saussureae Involueratae
Filtrate, Herba Saussureae Involueratae filtrate is concentrated into paste, is then dried to Herba Saussureae Involueratae dry extract, western red with above-mentioned
Flower, Fel Ursi powder, Moschus, the fine powder mix homogeneously of Borneolum Syntheticum, sieve；
Step D: take Oleum Sesami 1000g, immerses Radix Arnebiae (Radix Lithospermi) in Oleum Sesami, at twice in 115～125 DEG C of insulation dippings,
Each 30 minutes, remove slag, filter, obtain Oleum Radix Arnebiae (Oleum Radix Lithospermi)；
Step E: take Cera Flava 1.2g～1.5g by every 10g Oleum Radix Arnebiae (Oleum Radix Lithospermi), Cera Flava is added heat fusing, then with purple
Grass oil mix homogeneously, in temperature 121～130 DEG C of insulation 30-60min, treats that temperature is down to 50～65 DEG C, adds
Herba Saussureae Involueratae dry extract, Stigma Croci, Fel Ursi powder, Moschus, the fine powder of Borneolum Syntheticum, stir, fill, i.e.
Obtain compound saussurea involucrata salve for treating burn and scald.
Further technical scheme is that in step C, Herba Saussureae Involueratae filtrate is concentrated into relative density is 1.1～1.2
Paste, relative density heat at temperature 65 DEG C is surveyed.
Further technical scheme is that in step B, Stigma Croci, Fel Ursi powder, Moschus, Borneolum Syntheticum powder are broken into fine powder
Afterwards by No. 8 sieves, then by No. 9 sieves, by the powder of No. 9 sieves no less than 95%.
Further technical scheme is to take Herba Saussureae Involueratae 125g, Radix Arnebiae (Radix Lithospermi) 100g, Stigma Croci 0.5g in step A,
Fel Ursi powder 1.25g, Moschus 0.25g, Borneolum Syntheticum 37.5g.
Further technical scheme is, described Cera Flava add at temperature 125 DEG C～130 DEG C heat fusing 30～
60min。
Further technical scheme is that in step C, Herba Saussureae Involueratae filtrate is concentrated into paste, then passes through vacuum
It is dried or is spray-dried to Herba Saussureae Involueratae dry extract.
Further technical scheme is that described Moschus is artificial Moschus.
Below to further explanation explanation of the present invention.
Herba Saussureae Involueratae is mainly composed of alkaloid, flavone, sterol, volatile oil, aminoacid, xuelianlactone etc.,
Boiling, its operation purpose is the medicinal ingredient that more effectively extracts in Herba Saussureae Involueratae, relative to Oleum sesami
For high temperature soak extraction, more can guarantee that comprehensive proposition of its composition.
Stigma Croci contains various glycosides compositions, is ground into fine powder and is directly used as medicine, and soaks relative to Oleum sesami high temperature
For extraction, more can guarantee that its effective ingredient is not extracted loss or destroys.
In the present invention, Radix Arnebiae (Radix Lithospermi) is through following process: take Oleum Sesami 1000g, is immersed by Radix Arnebiae (Radix Lithospermi) in Oleum Sesami, divides two
Secondary insulation dipping, each 30 minutes, removes slag, filters, obtain Oleum Radix Arnebiae (Oleum Radix Lithospermi).Radix Arnebiae (Radix Lithospermi) immerses insulation leaching in Oleum Sesami
Stain, its objective is to extract the shikonin in Radix Arnebiae (Radix Lithospermi).The temperature of insulation dipping is 115～125 DEG C, root
According to the preferred embodiments of the present invention, the temperature of described insulation dipping is 120 DEG C.
In the present invention, take Cera Flava 1.2g～1.5g by every 10g Oleum Radix Arnebiae (Oleum Radix Lithospermi), Cera Flava is added heat fusing, then
Mix homogeneously with Oleum Radix Arnebiae (Oleum Radix Lithospermi)；The purpose selecting Cera Flava is to reduce substrates quantity, guarantee mastic molding effect, if
Use white vaseline can increase substrates quantity and mastic molding effect is poor.
In the present invention, Stigma Croci, Fel Ursi powder, Moschus, Borneolum Syntheticum directly mix after pulverizing, it is not necessary to use water
Or Oleum sesami soak extraction, its reason is to ensure that its effective ingredient is not extracted loss or destroys.And this
Bright middle Stigma Croci, Fel Ursi powder, Moschus, Borneolum Syntheticum directly mix with Cera Flava and Oleum Radix Arnebiae (Oleum Radix Lithospermi) with Herba Saussureae Involueratae dry extract,
The medicinal ingredient avoiding ointment causes medicinal ingredient character to change after high-temperature process, produces drug effect
Raw impact.
In the present invention, with Oleum Radix Arnebiae (Oleum Radix Lithospermi) in temperature 121～130 DEG C of insulations 15～30min after Cera Flava fusing, its
Purpose is killing microorganisms, reduces medicine load of microorganisms, and this is to ensure that the needs of the quality of the pharmaceutical preparations.
The present invention compared with prior art, has a following beneficial effect:
The manufacture method of the present invention farthest remains the drug effect of medicinal ingredient, ointment have heat reliving and toxin-eliminating,
Blood circulation promoting and blood stasis dispelling, the effect of removing the necrotic tissue and promoting granulation, can make the rapid pain relieving of empyrosis wound surface, and can control the wound surface layer that rots
Leaching is prolonged, and wound healing time shortens, and deep II ° of cicatrix spasm, arrectores pilorum and skin adhesion eliminate, without cicatrix,
Less for III ° of burn and scald area, it is not necessary to skin-grafting and prosthesis, can naturally repair after medication, scald
Curative effect is up to 98%.
The manufacture method cycle of the present invention is short, and technique is simple, can be applicable to industrialized production.
Detailed description of the invention
Embodiment
Patient Lee: male, 45 years old；Occupation: chemical plant worker.On October 26th, 2015 Deyang
Factory, because sodium sulfide solution conveyance conduit bursts apart, causes face arm and chest and back large area on the left of patient
Burn is admitted to hospital, and is tentatively judged as deep II degree of large-area burns through doctor.
Deep II degree of wound surface of burning is modal a kind of pathological change after skin burn, and it is deep that tissue injury reaches corium
Layer, requires to generate new associated with epithelial healing in 34 weeks through regular western medicine treatment.
Compound saussurea involucrata burn cream can improve depthⅡ° degree burn wound blood circulation, accelerates wound surface slough rotten
Rotten, bacteria growing inhibiting, promote wound surface epithelial growth, shorten the hospital stays.Therapeutic Method: patient is admitted to hospital
After venous transfusion at once, regulate Water-Electrolyte acid-base balance, apply extensive pedigree antibiotic infection, burn wound
After the simple debridement of face row, wound surface is changed dressings with compound saussurea involucrata burn cream soak, every day 1 time. continuously with 7 12
My god, using exposure method, safeguard that viscera function changes simultaneously, suit the medicine to the illness and nutritional support etc. treats.Patient uses
After medicine, every day observes the state of an illness, and carries out progress note.Medication wound surface substrate in the 3rd day is by pale or red and white
Turning ruddy, within the 12nd day, wound surface slough major part has been dissolved, part epithelial growth, the 18th day wound surface
Basic healing, without infecting, wound surface recovers good.
Below in conjunction with embodiments of the invention, the invention will be further elaborated.
Embodiment 1:
Take Herba Saussureae Involueratae 125g, Radix Arnebiae (Radix Lithospermi) 100g, Stigma Croci 0.5g, Fel Ursi powder 1.25g, artificial Moschus 0.25g,
Borneolum Syntheticum 37.5g；
Stigma Croci, Fel Ursi powder, artificial Moschus, Borneolum Syntheticum powder are broken into fine powder, sieve；
Herba Saussureae Involueratae boiling twice, decocts 1 hour, collecting decoction every time, filters to obtain Herba Saussureae Involueratae filtrate,
Herba Saussureae Involueratae filtrate is concentrated into the paste that relative density is 1.1 (65 DEG C of actual measurements), is then dried to Herba Saussureae Involueratae dry
Extract powder, mixs homogeneously with above-mentioned Stigma Croci, Fel Ursi powder, artificial Moschus, the fine powder of Borneolum Syntheticum, sieves,
Sterilizing；
Take Oleum Sesami 1000g, Radix Arnebiae (Radix Lithospermi) is immersed in Oleum Sesami, at twice insulation dipping at temperature 120 DEG C, every time
30 minutes, remove slag, filter, obtain Oleum Radix Arnebiae (Oleum Radix Lithospermi)；Concretely comprise the following steps and Oleum Sesami is divided into 2 parts, then by Radix Arnebiae (Radix Lithospermi)
It is placed in portion insulation dipping, impregnates during Radix Arnebiae (Radix Lithospermi) filtering residue is placed in another part again after filtration.
Take Cera Flava 1.2g by every 10g Oleum Radix Arnebiae (Oleum Radix Lithospermi), Cera Flava added heat fusing, then mixs homogeneously with Oleum Radix Arnebiae (Oleum Radix Lithospermi),
It is incubated 30min in temperature 125 DEG C, treats that temperature is down to 60 DEG C, add Herba Saussureae Involueratae dry extract, Stigma Croci, Bears
Gallbladder powder, artificial Moschus, the fine powder of Borneolum Syntheticum, stir and i.e. obtain compound saussurea involucrata salve for treating burn and scald.
The discriminating of compound saussurea involucrata salve for treating burn and scald is as follows:
(1) this product 5g, add water 20mL, micro-boiling 10 minutes, cooling, point water intaking layer, is evaporated, residue
Add ethanol 1mL and make dissolving, as need testing solution.Separately taking Herba Saussureae Involueratae control medicinal material 0.5g, it is right to be made in the same way of
According to medical material solution.Test according to thin layer chromatography (four general rules 0502 of " Chinese Pharmacopoeia " version in 2015),
Draw each 5 μ L of above two solution, put respectively in the silica gel G thin layer with sodium carboxymethyl cellulose as adhesive
On plate, with toluene-ethyl acetate-formic acid (5:4:1) as developing solvent, launching, take out, dry, spray is with 10%
Ferric chloride ethanol solution, is dried to spot development at 105 DEG C clear, in test sample chromatograph, with control medicinal material
On the position of chromatograph response, the speckle of aobvious same color.
(2) take Stigma Croci control medicinal material 0.1g, add ethanol 10mL, supersound process 15 minutes, filter, take
Filtrate is as control medicinal material solution.According to thin layer chromatography (four general rules 0502 of " Chinese Pharmacopoeia " version in 2015)
Test, draws Stigma Croci solution and each 5 μ L of need testing solution of (1), puts respectively in carboxymethyl cellulose
Sodium is on the silica gel g thin-layer plate of adhesive, with ethyl acetate-formic acid-water (4:1:1) as developing solvent, launches,
Take out, dry.In test sample chromatograph, on position corresponding with control medicinal material chromatograph, aobvious identical yellow
Speckle.
(3) taking this product 15g, add water 10mL, micro-boiling 10 minutes, cooling, point water intaking layer, water bath method,
Residue adds 10% sodium hydroxide solution 10mL, ultrasonic makes solution 120 DEG C add pyrohydrolysis 1 hour, and cooling is dripped
Salt adding acid for adjusting pH is to 2～3, with ethyl acetate extraction 2 times, each 10mL, united extraction liquid, water-bath
Being evaporated, residue adds ethanol 2mL makes dissolving, as need testing solution.Separately take ursodesoxycholic acid, add ethanol system
Become every 1mL solution containing 0.5mg, as reference substance solution.According to thin layer chromatography (" Chinese Pharmacopoeia " 2015
Year four general rules 0502 of version) test, take need testing solution and each 2 μ L of reference substance solution, put respectively in same
On silica gel g thin-layer plate with sodium carboxymethyl cellulose as adhesive, with the isobutyltrimethylmethane .-ether (isoamyl of new preparation
Ether) upper solution of-glacial acetic acid-n-butanol-water (10:5:5:3:1) is developing solvent, launches, takes out, dry,
Spray with 10% ethanol solution of sulfuric acid, be dried to spot development at 105 DEG C clear, in test sample chromatograph, with compare
On the position of medical material chromatograph response, the speckle of aobvious same color.
(4) take this product 1g, put in evaporating dish, upper lid surface ware, put 120 DEG C of heating 5～10min, cool down,
Rinsing surface plate with ethanol 1mL, solution is as need testing solution.Separately take Borneolum Syntheticum control medicinal material 10mg, add second
Alcohol 1mL makes dissolving, as control medicinal material solution, according to thin layer chromatography (" Chinese Pharmacopoeia " version in 2015
Four general rules 0502) test, take need testing solution and each 2 μ L of reference substance solution, put in same with carboxylic respectively
Sodium carboxymethylcellulose pyce is on the silica gel g thin-layer plate of adhesive, with toluene-acetone (20:1) as developing solvent, and exhibition
Opening, take out, dry, spray is with 10% ethanol solution of sulfuric acid, and it is clear that hot blast is blown to spot development.Test sample color
In spectrum, it is on the corresponding position of control medicinal material chromatograph, aobvious identical purple dot.
(5) take this product 20g, add ether 40mL, shaking, supersound extraction 10min, centrifugal 5min
(6000r/min), take supernatant liquid, in 150ml separatory funnel, add 3M sodium hydroxide solution 20mL,
Shaking, centrifugal layering, take supernatant liquid and volatilize, residue adds dehydrated alcohol 1mL makes dissolving, centrifugal
(12000r/min) 3min, taking supernatant is need testing solution.Separately take artificial muscone reference substance, add anhydrous
Every 1mL solution Han 1mg made by ethanol, as reference substance solution.According to gas chromatography (Chinese Pharmacopoeia 2010
Year one annex VI E of version) with cross-link 5% methyl-polysiloxane for fixing phase (HP-5 capillary column,
30m × 0.32mm, 0.25 μm)；Column temperature uses temperature programming: initial 120 DEG C, 10 DEG C/min is increased to 180 DEG C,
Keep 16min；Detector temperature is 280 DEG C；Nitrogen is carrier gas, and flow velocity is 1.3ml/min, number of theoretical plate
Must not calculate less than 10000 by artificial muscone.Draw reference substance solution and each 1 μ L of need testing solution respectively,
Injection gas chromatography instrument.Test sample chromatograph should present the chromatographic peak identical with reference substance chromatographic peak retention time.
Above-mentioned discriminating (1)～(5) illustrate the compound saussurea involucrata salve for treating burn and scald of the present invention exists Herba Saussureae Involueratae,
The active ingredient such as Stigma Croci, ursodesoxycholic acid, artificial Moschus and Borneolum Syntheticum, the manufacture method maximum journey of the present invention
The drug effect remaining medicinal ingredient of degree.
Being determined as follows of the Shikonin of compound saussurea involucrata salve for treating burn and scald:
(1) preparation of reference substance solution: precision weighs to put and is dried in exsiccator to horizontal heavy Shikonin
15mg, puts in 100mL measuring bottle, adds chloroform and makes dissolving in right amount, and be diluted to scale, shakes up.(every mL
In the 0.15mg Han Shikonin)
(2) standard curve making: accurate draw contrast solution 2.0,3.0,4.0,5.0,6.0mL, respectively
It is placed in 25mL measuring bottle, adds chloroform to scale, shake up, with chloroform as blank, according to Ultraviolet spectrophotometry
(four general rules 0401 of " Chinese Pharmacopoeia " version in 2015) measure absorbance at the wavelength of 523nm, to inhale
Luminosity be vertical coordinate, concentration be abscissa, draw standard curve.
(3) measure: precision weighs this product 0.1g, puts in 10mL measuring bottle, add chloroform and dissolve, and be diluted to
Scale, shakes up, and filters, and discards just filtrate, takes continuous filtrate according to Ultraviolet spectrophotometry (" Chinese Pharmacopoeia "
Four general rules 0401 of version in 2015) at the wavelength of 523nm, measure absorbance, read from standard curve and supply
The weight (μ g) of Shikonin in test product, calculates.Calculate the compound saussurea involucrata salve for treating burn and scald of the present invention
Middle Shikonin (C16H16O5) content not less than 0.16%.
Compound saussurea involucrata salve for treating burn and scald the mensuration of tauroursodeoxycholic acid content:
Measure according to high performance liquid chromatography (one annex VI D of " Chinese Pharmacopoeia " version in 2010).
Chromatographic condition and system suitability: with octadecylsilane chemically bonded silica as filler；With methanol-
Sodium dihydrogen phosphate (0.03mol/L) (68:32) (is first surveyed pH value, is added 0.1% triethylamine, then use phosphoric acid
Recall to original pH value) it is flowing phase；Detection wavelength is 210nm；Column temperature is 40 DEG C.Number of theoretical plate presses cattle
Sulphur ursodesoxycholic acid peak calculates should be not less than 2500.
The preparation of reference substance solution: take TUDCANa reference substance appropriate, accurately weighed, add methanol system
Become every 1ml solution containing 0.04mg, to obtain final product.
The preparation of need testing solution: take under content uniformity item to obtain this product about 5g, accurately weighed, put 50ml measuring bottle
In, add methanol appropriate, supersound process (power 300W, frequency 50kHZ) 10 minutes, let cool, use methanol
It is diluted to scale, shakes up, filter, take subsequent filtrate, to obtain final product.
Algoscopy: precision draws reference substance solution and need testing solution 20 μ l respectively, injects chromatograph of liquid,
Measure, by external standard method with calculated by peak area, to obtain final product.
The every 1g of this product contains Fel Ursi powder with tauroursodeoxycholic acid (C26H45NO8S) meter is no less than 0.40mg.
Clinical trial: carried out compound saussurea involucrata burn cream treatment burn and scald (light degree Ⅱ, deep II degree) multicenter,
At random, blind, parallel positive drug comparison clinical research, carried out 636 example clinical trials altogether.Shallow II degree
Burn and scald area less than 15%, deep II degree burn and scald area is less than 10%.
Pharmacological toxicology: extracorporeal bacteria inhibitor test shows, common skin antibacterial is infected by this product, such as golden yellow Fructus Vitis viniferae
The bacterial strains such as coccus, escherichia coli, bacillus pyocyaneus all have inhibitory action in various degree.This product is to rat skin
The degree of depth accompanies infection of staphylococcus aureus wound surface, to the burn companion's bacillus pyocyaneus sense of rat skin III degree after scalding
Dye wound surface has the effect promoting healing.This product xylol causes scorching mouse ear swelling inhibitory action.
Usage and the consumption of the compound saussurea involucrata salve for treating burn and scald of the present invention are as follows: hinder scald wound 0.9% physiology
Saline cleans, after burn and scald routine debridement, by every 80cm2Smearing 5g dose, larger area exposes
Therapy, area smaller with sterile gauze wrap up, change dressings every day or the next day change dressings.
The fusing point of the compound saussurea involucrata salve for treating burn and scald of the present invention is 47～50 DEG C of (" Chinese Pharmacopoeia " versions in 2015
Four general rule 0612 the 3rd methods).
Embodiment 2:
Take Herba Saussureae Involueratae 120g, Radix Arnebiae (Radix Lithospermi) 90g, Stigma Croci 0.5g, Fel Ursi powder 1.5g, artificial Moschus 0.4g, ice
Sheet 35g；
Stigma Croci, Fel Ursi powder, artificial Moschus, Borneolum Syntheticum powder are broken into fine powder, sieve；
Herba Saussureae Involueratae boiling twice, decocts 1 hour, collecting decoction every time, filters to obtain Herba Saussureae Involueratae filtrate,
Herba Saussureae Involueratae filtrate is concentrated into the paste that relative density is 1.2 (65 DEG C of actual measurements), is then dried to Herba Saussureae Involueratae dry
Extract powder, mixs homogeneously with above-mentioned Stigma Croci, Fel Ursi powder, artificial Moschus, the fine powder of Borneolum Syntheticum, sieves,
Sterilizing；
Take Oleum Sesami 1000g, Radix Arnebiae (Radix Lithospermi) is immersed in Oleum Sesami, at twice insulation dipping at temperature 125 DEG C, every time
30 minutes, remove slag, filter, obtain Oleum Radix Arnebiae (Oleum Radix Lithospermi)；
Take Cera Flava 1.2g by every 10g Oleum Radix Arnebiae (Oleum Radix Lithospermi), Cera Flava added heat fusing, then mixs homogeneously with Oleum Radix Arnebiae (Oleum Radix Lithospermi),
It is incubated 15min in temperature 125 DEG C, treats that temperature is down to 60 DEG C, add Herba Saussureae Involueratae dry extract, Stigma Croci, Bears
Gallbladder powder, artificial Moschus, the fine powder of Borneolum Syntheticum, stir and i.e. obtain compound saussurea involucrata salve for treating burn and scald.
Embodiment 3:
Take Herba Saussureae Involueratae 140g, Radix Arnebiae (Radix Lithospermi) 110g, Stigma Croci 0.4g, Fel Ursi powder 1.0g, artificial Moschus 0.2g,
Borneolum Syntheticum 40g；
Stigma Croci, Fel Ursi powder, artificial Moschus, Borneolum Syntheticum powder are broken into fine powder, sieve；
Herba Saussureae Involueratae boiling twice, decocts 1 hour, collecting decoction every time, filters to obtain Herba Saussureae Involueratae filtrate,
Herba Saussureae Involueratae filtrate is concentrated into the paste that relative density is 1.1 (65 DEG C of actual measurements), is then dried to Herba Saussureae Involueratae dry
Extract powder, mixs homogeneously with above-mentioned Stigma Croci, Fel Ursi powder, artificial Moschus, the fine powder of Borneolum Syntheticum, sieves,
Sterilizing；
Take Oleum Sesami 1000g, Radix Arnebiae (Radix Lithospermi) is immersed in Oleum Sesami, at twice insulation dipping at temperature 115 DEG C, every time
30 minutes, remove slag, filter, obtain Oleum Radix Arnebiae (Oleum Radix Lithospermi)；
Take Cera Flava 1.2g by every 10g Oleum Radix Arnebiae (Oleum Radix Lithospermi), Cera Flava added heat fusing, then mixs homogeneously with Oleum Radix Arnebiae (Oleum Radix Lithospermi),
At temperature 115 DEG C be incubated 30min, treat that temperature is down to 62 DEG C, add Herba Saussureae Involueratae dry extract, Stigma Croci,
Fel Ursi powder, artificial Moschus, the fine powder of Borneolum Syntheticum, stir and i.e. obtain compound saussurea involucrata salve for treating burn and scald.
Although reference be made herein to invention has been described for the explanatory embodiment of the present invention, and above-described embodiment is only
For the present invention preferably embodiment, embodiments of the present invention are also not restricted to the described embodiments, it should
Understanding, those skilled in the art can be designed that a lot of other amendments and embodiment, and these are revised and real
The mode of executing will fall within spirit disclosed in the present application and spirit.
Claims (7)
1. the manufacture method of a compound saussurea involucrata salve for treating burn and scald, it is characterised in that comprise the following steps:
Step A: take Herba Saussureae Involueratae 120～140g, Radix Arnebiae (Radix Lithospermi) 90～110g, Stigma Croci 0.4～0.5g, Fel Ursi powder
1.0～1.6g, Moschus 0.2～0.4g, Borneolum Syntheticum 35～40g；
Step B: Stigma Croci, Fel Ursi powder, Moschus, Borneolum Syntheticum powder are broken into fine powder, sieve；
Step C: Herba Saussureae Involueratae boiling twice, decocts 1 hour, collecting decoction every time, filters to obtain Herba Saussureae Involueratae
Filtrate, Herba Saussureae Involueratae filtrate is concentrated into paste, is then dried to Herba Saussureae Involueratae dry extract, with above-mentioned
Stigma Croci, Fel Ursi powder, Moschus, the fine powder mix homogeneously of Borneolum Syntheticum, sieve；
Step D: take Oleum Sesami 1000g, immerses Radix Arnebiae (Radix Lithospermi) in Oleum Sesami, at twice in temperature 115～125 DEG C of insulations
Dipping, each 30 minutes, removes slag, and filters, obtains Oleum Radix Arnebiae (Oleum Radix Lithospermi)；
Step E: take Cera Flava 1.2g～1.5g by every 10g Oleum Radix Arnebiae (Oleum Radix Lithospermi), Cera Flava is added heat fusing, then with purple
Grass oil mix homogeneously, in temperature 121～130 DEG C of insulations 30～60min, treats that temperature is down to 50～65 DEG C,
Add Herba Saussureae Involueratae dry extract, Stigma Croci, Fel Ursi powder, Moschus, the fine powder of Borneolum Syntheticum, stir,
Fill, i.e. obtains compound saussurea involucrata salve for treating burn and scald.
The manufacture method of compound saussurea involucrata salve for treating burn and scald the most according to claim 1, it is characterised in that step C
Middle Herba Saussureae Involueratae filtrate is concentrated into the paste that relative density is 1.1～1.2, and relative density is in temperature 65 DEG C
Lower heat is surveyed.
The manufacture method of compound saussurea involucrata salve for treating burn and scald the most according to claim 1, it is characterised in that step B
Middle Stigma Croci, Fel Ursi powder, Moschus, Borneolum Syntheticum powder pass through No. 8 sieves after being broken into fine powder, then by No. 9 sieves,
By the powder of No. 9 sieves no less than 95%.
The manufacture method of compound saussurea involucrata salve for treating burn and scald the most according to claim 1, it is characterised in that step A
In take Herba Saussureae Involueratae 125g, Radix Arnebiae (Radix Lithospermi) 100g, Stigma Croci 0.5g, Fel Ursi powder 1.25g, Moschus 0.25g,
Borneolum Syntheticum 37.5g.
The manufacture method of compound saussurea involucrata salve for treating burn and scald the most according to claim 1, it is characterised in that described
Cera Flava at temperature 125 DEG C～130 DEG C, add heat fusing 30～60min.
The manufacture method of compound saussurea involucrata salve for treating burn and scald the most according to claim 1, it is characterised in that step C
Middle Herba Saussureae Involueratae filtrate is concentrated into paste, is then soaked to Herba Saussureae Involueratae is dry by vacuum drying or spray drying
Cream powder.
The manufacture method of compound saussurea involucrata salve for treating burn and scald the most according to claim 1, it is characterised in that described
Moschus be artificial Moschus.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177247A (en) * | 2016-08-26 | 2016-12-07 | 聚善堂（福建）医药集团有限公司 | A kind of compound recipe burn cream and preparation method thereof |
| CN107334816A (en) * | 2017-05-08 | 2017-11-10 | 张友明 | A kind of skin scald agent |
| US9999643B2 (en) | 2016-10-19 | 2018-06-19 | Sultan Qaboos Univeristy | Therapeutic composition for treating gangrene |
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| CN102614277A (en) * | 2011-10-14 | 2012-08-01 | 姚邦乾 | Method for drug treating water and fire scalds, and ulcerative carbuncles |
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| CN1139571A (en) * | 1996-03-14 | 1997-01-08 | 杨政华 | Ointment for burns made of Saussurea Involucrata |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106177247A (en) * | 2016-08-26 | 2016-12-07 | 聚善堂（福建）医药集团有限公司 | A kind of compound recipe burn cream and preparation method thereof |
| US9999643B2 (en) | 2016-10-19 | 2018-06-19 | Sultan Qaboos Univeristy | Therapeutic composition for treating gangrene |
| CN107334816A (en) * | 2017-05-08 | 2017-11-10 | 张友明 | A kind of skin scald agent |
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| CN105878605B (en) | 2019-10-11 |
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