CN105233269A - Medicine compound treating local burns - Google Patents
Medicine compound treating local burns Download PDFInfo
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- CN105233269A CN105233269A CN201510818560.2A CN201510818560A CN105233269A CN 105233269 A CN105233269 A CN 105233269A CN 201510818560 A CN201510818560 A CN 201510818560A CN 105233269 A CN105233269 A CN 105233269A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a medicine compound treating local burns. The medicine compound is prepared from, by weight, 10-18 parts of Chinese trumpet creepers, 20-30 parts of gadflies, 18-28 parts of ardisia japonica, 10-20 parts of herba siegesbeckiae, 25-35 parts of caulis pipers futokadsurae, 9-18 parts of ramie roots, 10-22 parts of aizoon stonecrop herb, 17-26 parts of peanut coats, 10-22 parts of hydrargyrum oxydatum crudum, 15-30 parts of daphne genkwa, 10-18 parts of long-noded pit vipers and 0.0002-0.0008 part of recombinant human epidermal growth factors. The medicine compound treating the local burns can promote tissue regeneration to heal sore, cool blood and stop bleeding, clear away heat and toxic materials, achieve antisepsis and anti-inflammation functions, promote wound healing and remove scars. The compound is lasting in activity.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly a kind of pharmaceutical composition for the treatment of topical burn.
Background technology
Burn and refer to by heating power and action of chemicals after human body, to the damage that the local organization of human body causes.Heating power wherein comprises burn and scald, cold injury and electricity wound etc.Western medical treatment is burnt and main is adopted hydrogen peroxide debridement and through liquid medicine disinfecting hemostasis, and the sterilizing objects such as iodine tincture, takes antibiotic medicine in also needing simultaneously.But, can not mercurochrome be used when the wound of burning is darker, and red tribute can not use with iodine, easily make human body generation iodate tribute poisoning.
Chinese traditional treatment is burnt and is usually used water solublity Chinese medicine preparation, and disclosed in No. 1583027A, Chinese patent, name is called that in " trauma hemostasis granulation promoting Chinese medicine powder ", proposition adopts pearl sand grass meal end, the mixing of Herba Chenopodii Hybridi powder, chinese Pulsatilla Root, Herba Erodii powder and borneol powder is mixed with a kind of liniment.Herba Chenopodii Hybridi in this Chinese medicine powder has treating blood disorders cooling blood for hemostasis effect, and the Radix Pulsatillae has heat-clearing and toxic substances removing, removing heat from blood effect, and Borneolum Syntheticum can clearing away heat to alleviate pain.Although this Chinese medicine powder can stop blooding to a certain extent, the effect such as heat-clearing and toxic substances removing and pain relieving, can it lacks raw myofunctional medicine, need to inquire into further for close trauma wound.
Ling Shadan abides by ancient big gun to process and clarify saturated colloid solution, Main Ingredients and Appearance with the sepia using modern science technique to extract: Rhizoma Smilacis Glabrae, Radix Et Rhizoma Rhei, Cortex Phellodendri, Flos Lonicerae, Fructus Forsythiae, Flos Carthami, Radix Arnebiae (Radix Lithospermi), Olibanum, Myrrha, Radix Angelicae Sinensis, the Radix Astragali, the Radix Angelicae Dahuricae, Pheretima, Borneolum Syntheticum etc.Although this kind of Chinese medicine, without hormone, has no side effect, there is good anti-inflammation, wound healing effect, but with regard to the wound of burning, even if there is no external used medicine, also can clear-cutting forestland as long as no inflammation, main problem easily occurs cicatrix in wound site.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition for the treatment of topical burn, said composition promoting tissue regeneration and ulcer healing, cooling blood for hemostasis, heat-clearing and toxic substances removing, anti-inflammation, wound healing, and can remove cicatrix.
For achieving the above object, the present invention adopts following technical scheme:
The invention provides a kind of pharmaceutical composition for the treatment of topical burn, be made up of the raw material of following weight portion: Flos Campsis 10 ~ 18 parts, Tabanus 20 ~ 30 parts, Herba Ardisiae Japonicae 18 ~ 28 parts, Herba Siegesbeckiae 10 ~ 20 parts, Caulis Piperis Kadsurae 25 ~ 35 parts, Radix Boehmeriae 9 ~ 18 parts, Herba Sedi Aizoon 10 ~ 22 parts, Testa arachidis hypogaeae 17 ~ 26 parts, Hydrargyri Oxydum Rubrum 10 ~ 22 parts, Flos Genkwa 15 ~ 30 parts, Agkistrodon 10 ~ 18 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
Preferably, the pharmaceutical composition for the treatment of topical burn of the present invention, is made up of the raw material of following weight portion: Flos Campsis 12 ~ 16 parts, Tabanus 23 ~ 27 parts, Herba Ardisiae Japonicae 21 ~ 25 parts, Herba Siegesbeckiae 13 ~ 17 parts, Caulis Piperis Kadsurae 28 ~ 32 parts, Radix Boehmeriae 11 ~ 15 parts, Herba Sedi Aizoon 14 ~ 18 parts, Testa arachidis hypogaeae 19 ~ 23 parts, Hydrargyri Oxydum Rubrum 12 ~ 20 parts, Flos Genkwa 20 ~ 25 parts, Agkistrodon 12 ~ 16 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
More preferably, the pharmaceutical composition for the treatment of topical burn of the present invention, is made up of the raw material of following weight portion: Flos Campsis 14 parts, Tabanus 25 parts, Herba Ardisiae Japonicae 23 parts, Herba Siegesbeckiae 15 parts, Caulis Piperis Kadsurae 30 parts, Radix Boehmeriae 13 parts, Herba Sedi Aizoon 16 parts, Testa arachidis hypogaeae 21 parts, Hydrargyri Oxydum Rubrum 16 parts, Flos Genkwa 23 parts, Agkistrodon 14 parts, recombinant human epidermal growth factor 0.0005 part.
In raw material of the present invention, Flos Campsis removing blood stasis stimulates the menstrual flow, and removing heat from blood is dispelled; Tabanus removing blood stasis stimulates the menstrual flow, Zhu Yu Xiao Disorder; Herba Ardisiae Japonicae relieving cough and asthma, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling; Herba Siegesbeckiae expelling wind and removing dampness, dredge the meridian passage, heat-clearing and toxic substances removing; Caulis Piperis Kadsurae wind-damp dispelling, the meridian dredging; Radix Boehmeriae cooling blood for hemostasis, antiabortive, heat-clearing and toxic substances removing; Herba Sedi Aizoon removing stasis to stop bleeding, reducing swelling and alleviating pain, mind tranquilizing and the heart calming; Testa arachidis hypogaeae astringing to arrest bleeding; Drawing out pus by applying a plaster to the affected part of Hydrargyri Oxydum Rubrum is rotten, promoting tissue regeneration and ulcer healing; Flos Genkwa removing fluid-retention by purgation, expelling phlegm for arresting cough, parasite killing treats skin ulcer; Agkistrodon dispelling wind and removing obstruction in the collateral, arresting convulsion relieving convulsion; Recombinant human epidermal growth factor hemostasis and pain-relieving, removing toxic substances and promoting subsidence of swelling, promotion tissue regeneration, tool reparation and organize nascent capacity, can high efficiency anti-inflammatory, promote cytothesis and tissue newborn, impel the growth fast of the tissues such as muscle, epidermis, muscle arteries and veins, blood vessel, without cicatrix more.
Beneficial effect of the present invention is:
1, Flos Campsis of the present invention, Tabanus, Herba Ardisiae Japonicae, Herba Siegesbeckiae, Caulis Piperis Kadsurae, Radix Boehmeriae, Herba Sedi Aizoon, Testa arachidis hypogaeae, Hydrargyri Oxydum Rubrum, Flos Genkwa, Agkistrodon and recombinant human epidermal growth factor reasonable compatibility, play promoting tissue regeneration and ulcer healing altogether, cooling blood for hemostasis, heat-clearing and toxic substances removing, anti-inflammation, promote local woanded surface healing, and cicatrix can be removed, cure and take short effect.
2, Flos Campsis of the present invention, Tabanus, Herba Ardisiae Japonicae, Herba Siegesbeckiae, Caulis Piperis Kadsurae, Radix Boehmeriae, Herba Sedi Aizoon, Testa arachidis hypogaeae, Hydrargyri Oxydum Rubrum, Flos Genkwa, Agkistrodon and recombinant human epidermal growth factor compatibility can keep the activity of recombinant human epidermal growth factor, recombinant human epidermal growth factor can also be helped to go deep into deep skin fast, improve drug effect, remarkable accelerated wound healing.
3, recombinant human epidermal growth factor of the present invention can promote the synthesis of DNA, RNA and hydroxyproline in skin wound process of tissue reparation, the epidermis cell of differentiation-inducing maturation reverses and turns to epidermal stem cells, accelerate the generation of wound granulation tissue and epithelial propagation, thus shorten the healing time of wound surface, improve wound repair quality, there are soft skin, slow down aging, reduce the effect of wound surface cicatrization.
4, compositions of the present invention has immunoregulation effect, can strengthen liver and gall cell autoimmunity function, and opposing poisoning intrusion, also can improve body non-specific immunity, increases the generation of antibody, has analgesic effect simultaneously.
5, compositions of the present invention effectively can treat local burn and scald, cold injury, electricity wound, chemical substance burns, short treating period, no pain, and does not leave over any cicatrix or hyaline thrombus.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited to these embodiments.
Embodiment 1
Treat a pharmaceutical composition for topical burn, be made up of the raw material of following weight portion: Flos Campsis 18 parts, Tabanus 20 parts, Herba Ardisiae Japonicae 28 parts, Herba Siegesbeckiae 20 parts, Caulis Piperis Kadsurae 25 parts, Radix Boehmeriae 18 parts, Herba Sedi Aizoon 10 parts, Testa arachidis hypogaeae 26 parts, Hydrargyri Oxydum Rubrum 10 parts, Flos Genkwa 30 parts, Agkistrodon 10 parts, recombinant human epidermal growth factor 0.0008 part.
The preparation method of the pharmaceutical composition of described treatment topical burn is as follows:
1) by Flos Campsis, Tabanus, Herba Ardisiae Japonicae, Herba Siegesbeckiae, Caulis Piperis Kadsurae, Radix Boehmeriae, Herba Sedi Aizoon, Testa arachidis hypogaeae, Hydrargyri Oxydum Rubrum, Flos Genkwa and Agkistrodon, 100 orders are crushed to;
2) by step 1) Chinese medicinal powder that obtains puts into pressure pan, and then adding its weight 12 times of volumetric concentrations is the alcoholic solution of 60%, is forced into 4kgf/cm
2, make its pressure uniform, and keep 3min, recover normal pressure, obtain serosity;
3) by serosity reflux, extract 3 times, each 1.5h, merge extractive liquid, decompression recycling ethanol;
4) placement is spent the night, and filters, and by filtrate by macroporous resin eluting, being concentrated into relative density is 1.1, obtains paste;
5) paste is mixed homogeneously with recombinant human epidermal growth factor.
Embodiment 2
Treat a pharmaceutical composition for topical burn, be made up of the raw material of following weight portion: Flos Campsis 12 parts, Tabanus 27 parts, Herba Ardisiae Japonicae 21 parts, Herba Siegesbeckiae 17 parts, Caulis Piperis Kadsurae 28 parts, Radix Boehmeriae 15 parts, Herba Sedi Aizoon 14 parts, Testa arachidis hypogaeae 23 parts, Hydrargyri Oxydum Rubrum 12 parts, Flos Genkwa 25 parts, Agkistrodon 12 parts, recombinant human epidermal growth factor 0.0004 part.
Preparation method is with embodiment 1
Embodiment 3
Treat a pharmaceutical composition for topical burn, be made up of the raw material of following weight portion: Flos Campsis 14 parts, Tabanus 25 parts, Herba Ardisiae Japonicae 23 parts, Herba Siegesbeckiae 15 parts, Caulis Piperis Kadsurae 30 parts, Radix Boehmeriae 13 parts, Herba Sedi Aizoon 16 parts, Testa arachidis hypogaeae 21 parts, Hydrargyri Oxydum Rubrum 16 parts, Flos Genkwa 23 parts, Agkistrodon 14 parts, recombinant human epidermal growth factor 0.0005 part.
Preparation method is with embodiment 1
Embodiment 4
Treat a pharmaceutical composition for topical burn, be made up of the raw material of following weight portion: Flos Campsis 16 parts, Tabanus 23 parts, Herba Ardisiae Japonicae 25 parts, Herba Siegesbeckiae 13 parts, Caulis Piperis Kadsurae 32 parts, Radix Boehmeriae 11 parts, Herba Sedi Aizoon 18 parts, Testa arachidis hypogaeae 19 parts, Hydrargyri Oxydum Rubrum 20 parts, Flos Genkwa 20 parts, Agkistrodon 16 parts, recombinant human epidermal growth factor 0.0006 part.
Preparation method is with embodiment 1
Embodiment 5
Treat a pharmaceutical composition for topical burn, be made up of the raw material of following weight portion: Flos Campsis 10 parts, Tabanus 30 parts, Herba Ardisiae Japonicae 18 parts, Herba Siegesbeckiae 10 parts, Caulis Piperis Kadsurae 35 parts, Radix Boehmeriae 9 parts, Herba Sedi Aizoon 22 parts, Testa arachidis hypogaeae 17 parts, Hydrargyri Oxydum Rubrum 22 parts, Flos Genkwa 15 parts, Agkistrodon 18 parts, recombinant human epidermal growth factor 0.0002 part.
Preparation method is with embodiment 1
Test example
Carried out testing experiment to localized burn, scald, cold injury, electricity wound and chemical substance burn patients respectively with the pharmaceutical composition of the treatment topical burn of embodiment 1 ~ 5, testing program is as follows:
Every 4 hours of every day used once, or used as required, until use to wound healing, observed result of use.
The using method of the pharmaceutical composition for the treatment of topical burn: get appropriate compositions, is directly applied to wound face or compositions is placed in right amount on clean finger or cotton swab, being applied to wound face.
Clinical treatment testing result is in table 1, as follows:
Table 1 embodiment of the present invention 1 ~ 5 treats topical burn clinical treatment testing result
Test example 2: the pharmaceutical composition active testing data for the treatment of topical burn of the present invention
The pharmaceutical composition of the treatment topical burn of the present invention's 5 embodiments is regularly carried out active testing, obtains the result as following table 2:
The pharmaceutical composition active testing data of table 2 treatment topical burn of the present invention
As can be seen from data above, the pharmaceutical composition activity-maintaining time for the treatment of topical burn of the present invention is permanent, and lasting rate at least can reach 3 years.
Claims (3)
1. treat a pharmaceutical composition for topical burn, it is characterized in that, be made up of the raw material of following weight portion: Flos Campsis 10 ~ 18 parts, Tabanus 20 ~ 30 parts, Herba Ardisiae Japonicae 18 ~ 28 parts, Herba Siegesbeckiae 10 ~ 20 parts, Caulis Piperis Kadsurae 25 ~ 35 parts, Radix Boehmeriae 9 ~ 18 parts, Herba Sedi Aizoon 10 ~ 22 parts, Testa arachidis hypogaeae 17 ~ 26 parts, Hydrargyri Oxydum Rubrum 10 ~ 22 parts, Flos Genkwa 15 ~ 30 parts, Agkistrodon 10 ~ 18 parts, recombinant human epidermal growth factor 0.0002 ~ 0.0008 part.
2. the pharmaceutical composition for the treatment of topical burn according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Flos Campsis 12 ~ 16 parts, Tabanus 23 ~ 27 parts, Herba Ardisiae Japonicae 21 ~ 25 parts, Herba Siegesbeckiae 13 ~ 17 parts, Caulis Piperis Kadsurae 28 ~ 32 parts, Radix Boehmeriae 11 ~ 15 parts, Herba Sedi Aizoon 14 ~ 18 parts, Testa arachidis hypogaeae 19 ~ 23 parts, Hydrargyri Oxydum Rubrum 12 ~ 20 parts, Flos Genkwa 20 ~ 25 parts, Agkistrodon 12 ~ 16 parts, recombinant human epidermal growth factor 0.0004 ~ 0.0006 part.
3. the pharmaceutical composition for the treatment of topical burn according to claim 1, is characterized in that, is made up of the raw material of following weight portion: Flos Campsis 14 parts, Tabanus 25 parts, Herba Ardisiae Japonicae 23 parts, Herba Siegesbeckiae 15 parts, Caulis Piperis Kadsurae 30 parts, Radix Boehmeriae 13 parts, Herba Sedi Aizoon 16 parts, Testa arachidis hypogaeae 21 parts, Hydrargyri Oxydum Rubrum 16 parts, Flos Genkwa 23 parts, Agkistrodon 14 parts, recombinant human epidermal growth factor 0.0005 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510818560.2A CN105233269A (en) | 2015-11-23 | 2015-11-23 | Medicine compound treating local burns |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510818560.2A CN105233269A (en) | 2015-11-23 | 2015-11-23 | Medicine compound treating local burns |
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| Publication Number | Publication Date |
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| CN105233269A true CN105233269A (en) | 2016-01-13 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510818560.2A Pending CN105233269A (en) | 2015-11-23 | 2015-11-23 | Medicine compound treating local burns |
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Citations (5)
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|---|---|---|---|---|
| CN101002799A (en) * | 2007-01-06 | 2007-07-25 | 程秀平 | Ointment for treating serious burns, and its preparing method |
| CN101920005A (en) * | 2010-05-20 | 2010-12-22 | 江其生 | Novel skin radiation injury protective agent |
| CN102091258A (en) * | 2011-03-03 | 2011-06-15 | 吴强 | Chinese medicinal composition for dispelling scars and preparation method thereof |
| CN104001142A (en) * | 2014-06-13 | 2014-08-27 | 张海涛 | Traditional Chinese medicine composition for treating wounds and bone fractures |
| CN104857290A (en) * | 2015-05-26 | 2015-08-26 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine disinfection ointment for treating scalds and burns and preparation method thereof |
-
2015
- 2015-11-23 CN CN201510818560.2A patent/CN105233269A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002799A (en) * | 2007-01-06 | 2007-07-25 | 程秀平 | Ointment for treating serious burns, and its preparing method |
| CN101920005A (en) * | 2010-05-20 | 2010-12-22 | 江其生 | Novel skin radiation injury protective agent |
| CN102091258A (en) * | 2011-03-03 | 2011-06-15 | 吴强 | Chinese medicinal composition for dispelling scars and preparation method thereof |
| CN104001142A (en) * | 2014-06-13 | 2014-08-27 | 张海涛 | Traditional Chinese medicine composition for treating wounds and bone fractures |
| CN104857290A (en) * | 2015-05-26 | 2015-08-26 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine disinfection ointment for treating scalds and burns and preparation method thereof |
Non-Patent Citations (8)
| Title |
|---|
| 李锦开: "《中国基本药材》", 31 January 2013 * |
| 杨卫平: "《临床常用中药手册》", 31 January 2001 * |
| 杨雄志: "《中医药基础 第2版》", 31 December 2014 * |
| 耿耘: "《中医学基础与中药学自学导读》", 30 September 2014 * |
| 胡小勤: "《中药学》", 31 January 2014 * |
| 袁长季: "《中医药学概论》", 31 August 2011 * |
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Application publication date: 20160113 |