CN103656244A - Partial nursing matter capable of improving discomfort after healing of knife cut wounds - Google Patents
Partial nursing matter capable of improving discomfort after healing of knife cut wounds Download PDFInfo
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Abstract
The invention discloses a partial nursing matter capable of improving the discomfort after the healing of knife cut wounds and aims to solve the treatment problem that the wounds feel uncomfortable after a suturing surgery. The partial nursing matter is characterized by being prepared from following crude drugs in parts by weight: blackend swallowwort root, Chinese buckeye seeds, loose knots, rice-paper plants, semen litchi, ivy glorybind herb roots, paris polyphylla, asterina pectinifera, aralia chinensis, mustard plaster powder, magnets and lobed kudzuvine roots. Clinical experiments show that the partial nursing matter has the characteristics of good curative effects and higher safety on treating the discomfort of the wounds after the suturing surgery. The partial nursing matter is worthy of being clinically applied and popularized.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of improvement and lancinate and hinder Local Nursing Care thing uncomfortable after wound healing.
Background technology
The feature of the wound of lancinating is wound neat in edge, and after wound is sewed up, most wounds can obtain primary healing.But a multicenter clinical investigation shows, the in the situation that of primary healing, local without red, swollen, hot, bitterly and ooze out, still there is 32.63% patient after suture, in one month, to have obvious wound sense of discomfort, show as numbness, pain, paraesthesia and local skin and harden, the Proportion of patients three months time after suture with wound sense of discomfort is still 24.67%.
This its reason complexity of delay wound sense of discomfort is various, lancinates while hindering on the one hand, and cortex, connective tissue layer, flesh layer, tegumentary nerve has damage in various degree; On the other hand in local soft tissue repair process, due to patient body quality factor, cause interstitial fibers connective tissue (extracellular matrix) hyperplasia degree higher than normal parenchyma cytothesis process, what only remedy due to this kind of fibrous connective tissue is local form rather than the 26S Proteasome Structure and Function of local parenchyma, causes local discomfort and skin hardening.
Still lack at present the therapeutic scheme for sense of discomfort after wound healing after this kind of suture, clinician is many causes local stagnation of QI-blood to explain according to partial cut incised wound, and recommend patient's external safflower oil blood circulation promoting and blood stasis dispelling, but because there is no stagnation of QI-blood, this pathogenesis system exists, so this kind of therapeutic scheme is substantially invalid.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and the little improvement of side effect is lancinated and hindered uncomfortable Local Nursing Care thing after wound healing.
The technical scheme that the present invention solves its technical problem is: a kind of improvement is lancinated and hindered Local Nursing Care thing uncomfortable after wound healing, it is characterized in that being prepared from by the crude drug of following weight proportion: 10～30 parts of Radix Tylophorae arenicolaes, 6～12 parts of Semen Aesculies, 3～10 parts of Lignum Pini Nodis, go back 6～12 parts, bobbin, 3～10 parts of Semen Litchis, 6～12 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 6～12 parts of Rhizoma Paridis, 6～12 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 6～12 parts of Cortex erythrinaes, 1～5 part, emplastra sinapis powder, 3～10 parts of Magnetitums, 10～25 parts of Radix Puerariaes.
Chinese medicine of the present invention is that the raw material by following optimum weight part proportioning is prepared from: 20 parts of Radix Tylophorae arenicolaes, 10 parts of Semen Aesculies, 6 parts of Lignum Pini Nodis, go back 10 parts, bobbin, 6 parts of Semen Litchis, 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 10 parts of Rhizoma Paridis, 10 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 10 parts of Cortex erythrinaes, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
Wherein said: Radix Tylophorae arenicolae is the spirit of asclepiadaceae plant bamboo disappear root or the aerial parts of Cynanchum inamoenum (Maxim.) Loes..Nature and flavor are bitter; Micro-pungent; Property is put down.Return lung meridian.Merit can the kidney invigorating, spleen invigorating, removing toxic substances.
Semen Aesculi is Hippocastanaceae plant Aesculus chinensis Bunge Aesculus chinensis Bge., Radix Aesculi Aesculus chinensis Bge.var.chekiangensis(Hu et Fang) dry mature seed of Fang or Aesculus Aesculus wilsonii Rehd..Nature and flavor are sweet, temperature.Return liver, stomach warp.Merit can regulating the flow of QI to ease the stomach, and stomach and alleviating pain.
Lignum Pini Nodi, for Pinus tabulaeformis tabulaeformis Carr, secondly be Pinus densiflora (short leaf Pinus densiflora) Pinus densiflora Sieb.et Zucc., Folium seu Strobilus Pini sibiricae Pinus sibirica(Loud.) Lignum Pini Nodis of Mayr., Pinus koraiensis (Korean pine) Pinus koraiensis Sieb.et Zucc., Pinus armandi Franch-P. Komavovii Lavl. (Lignum Pini Nodi, five must pine) Pinus armandii Franch. and Pinus massoniana Lamb, pinus yunnanensis faranch, Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen etc., or be the knob that pinaster grows after sick.Bitter in the mouth; Warm in nature.Return liver; Kidney channel.Merit can dispeiling pathogenic wind and removing dampness; Channels sootheing and network vessel quickening; Promoting blood circulation and stopping pain.
Bobbin also, the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head headache; Weak breath consumption of essence; Early whitening of beard and hair.
Semen Litchi is the dry mature seed of sapindaceous plant Fructus Litchi Litchichinensis Sonn..Sweet, the micro-hardship of nature and flavor, temperature.Return liver, kidney channel.Merit can promoting QI to circulate and dispersing the agglomeration of the pathogens, cold-dispelling pain-relieving.
Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) is herb or the root of the plant DAWANHUA Calystegia hederacea Wall. of dicotyledon scammonia section.Property sweet and slightly bitter taste; Flat.Return liver; Kidney channel.Merit can spleen invigorating; Dampness removing; Regulating menstruation.
Rhizoma Paridis is the rhizome of liliaceous plant Rhizoma Paridis Paris polyphylla Sm..Hardship, is slightly cold.Enter Liver Channel.Merit can heat-clearing and toxic substances removing, detumescence, spasmolytic.
Potiria pectinifera (Mukller et Tro Sehel), is Echinodermata Asterinidae Potiria pectinifera (Mukller et Tro Sehel) Asterina pectinifera Miller et Troschel, with all (removing internal organs), is used as medicine.Nature and flavor are salty, and temperature is nontoxic.Merit can YIN nourishing, tonifying YANG, wind-damp dispelling.
Cortex erythrinae is bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..Nature and flavor are bitter, flat.Return liver, kidney channel.Merit can wind-damp dispelling, channels sootheing and network vessel quickening.Wind-damp dispelling, the meridian dredging, parasite killing.
Emplastra sinapis powder is crucifer Caulis et Folium Sinapis albee Sinapis alba L. or mustard Brassica juncea(L.) dry mature seed of Czern.et Coss., after dry grinds, remove fatty oil and obtain.Nature and flavor are pungent, temperature.Return lung meridian.Merit can warming the lung eliminating phlegm promoting the circulation of QI, resolving mass and removing the obstruction of the collateral pain relieving.
Magnetitum, is oxide-based mineral spinelle family magnetic iron ore, main containing ferroso-ferric oxide (Fe3O4).Salty, cold.Return liver heart kidney channel.Merit can suppressing the hyperactive liver and subsiding YANG, hearing-improing and eyesight improving, tranquillizing the mind by relieving convulsion, helping inspiration to relieve asthma.
Radix Puerariae, Radix Puerariae is the root of leguminous plant Pachyrhizua angulatus.Sweet, pungent, flat.Enter spleen, stomach warp.Merit can be induced sweat, rash, and relaxing muscles and tendons, promotes the production of body fluid, antidiarrheal.
Composition principle: lancinate and hinder wound and do not feel like oneself and refer to the in the situation that of wound primary healing, local without red, swollen, hot, bitterly and ooze out, and patient has obvious former wound sense of discomfort, shows as numbness, pain, paraesthesia and local skin and hardens.This kind of its reason complexity of sense of discomfort is various, cortex, connective tissue layer, flesh layer after one side wound, and tegumentary nerve has damage in various degree; On the other hand in local soft tissue repair process, due to patient body quality factor, cause interstitial fibers connective tissue (extracellular matrix) hyperplasia degree higher than normal parenchyma cytothesis process, what only remedy due to this kind of fibrous connective tissue is local form rather than the 26S Proteasome Structure and Function of local parenchyma, causes local discomfort and skin hardening.Still lack at present the therapeutic scheme for sense of discomfort after this kind of wound healing, clinician is many causes local stagnation of QI-blood to explain according to local wound, and recommend patient's external safflower oil blood circulation promoting and blood stasis dispelling, but because there is no stagnation of QI-blood, this pathogenesis system exists, so this kind of therapeutic scheme is substantially invalid.
Compared with prior art, the present invention has following characteristics:
1, we adopt Radix Tylophorae arenicolae and Semen Aesculi to coordinate for monarch drug: lung and skin phase the exterior and the interior, described Radix Tylophorae arenicolae enters lung meridian, can be by adjusting being entangled with of lung network skin, the albumen that Radix Tylophorae arenicolae decocting liquid can improve due to the inflammation cyst that antagonism mice carboxymethyl cellulose causes oozes out and leukocyte migration, promotes parenchyma hypertrophy; And the total Saponin 5mg/kg of Semen Aesculi is applied topically to, in rat Ovum Gallus domesticus album connective tissue stimulation model, can suppress fibrous connective tissue hypertrophy.
2, inventor's clinical empirical summary draws, after suture wound do not feel like oneself relevant with local channels apoplexy cold-damp after wound, so we adopt Lignum Pini Nodi, Cortex erythrinae, Semen Litchi wind-damp dispelling, the meridian dredging; The reason of choosing this three herbal medicine in numerous related drugs is, these three kinds of Drugs are gentle, and non-dispelling the damp pathogen with drugs of bitter in taste and cold in nature does not have the anxiety of impairment of YIN.And the Ginkgolide Component columbin containing in Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) tuber has mate-assist to suppress fibrous connective tissue hypertrophy.
3, after suture, wound discomfort is also relevant with the dry impairment of YIN of local blood, and stirring of wind due to deficiency of YIN and numbness, fiber crops itch, so we adopt, goes back bobbin tonify deficiency subduing the wind syndrome, Potiria pectinifera (Mukller et Tro Sehel) YIN nourishing and YANG strengthening wind-damp dispelling, and the two is the product of reinforcement and elimination in combination, without growing greasy anxiety.
4, Semen Sinapis eliminating phlegm eliminating stagnation, after suture, wound discomfort belongs to the wound of primary healing, and this kind of wound acute stage, is mistake, and cold-phlegm residual in meridians is all more obstinate, so add Semen Sinapis to coordinate Semen Litchi to help tonneau.Semen Sinapis is containing potassium myronate, potassium myronate is met water and is generated volatile oil through the effect of myrosase, and main component is allyl isosulfocyanate, has stimulation, be applied to skin, there is warm sensation and make it rubescent, even causing blister, pustule, so adopt emplastra sinapis powder in prescription of the present invention, be that mustard flour is removed gained after fatty oil, this kind of de-fatty oil method is for conventional in the industry, and emplastra sinapis powder can directly be buied from market, sufficient raw.But because the present invention need to surpass 3 hours in local action, so coordinate Radix Puerariae, Radix Puerariae contains much starch, can alleviate the skin irritation of Semen Sinapis.
5, the reason of choosing Rhizoma Paridis in the medicine of numerous heat-clearing and toxic substances removing is, the non-bitter cold of this medicine but be slightly cold, and have the merit of spasmolytic, there is the effect of tonneau venation.Its our full presciption medicine partial heat adds cold and cool medicine simply in many hot medicines, also has the merit of using corrigent.
6, Magnetitum is originally the product in important city, but rat local topical, and can make local neutrophilic granulocyte engulf reaction increases.
7, avoid using the promoting the circulation of blood medicine of taking offence, reducing local fibroplasia initiating stimulates.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts of Radix Tylophorae arenicolaes, 10 parts of Semen Aesculies, 6 parts of Lignum Pini Nodis, go back 10 parts, bobbin, 6 parts of Semen Litchis, 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 10 parts of Rhizoma Paridis, 10 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 10 parts of Cortex erythrinaes, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
The preparation method of embodiment 1 is: by Radix Tylophorae arenicolae, Semen Aesculi, Lignum Pini Nodi, go back bobbin, Semen Litchi, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Rhizoma Paridis, Potiria pectinifera (Mukller et Tro Sehel), Cortex erythrinae, emplastra sinapis powder (decocting a drug wrapped), Magnetitum, Radix Puerariae mixing and water adding and decoct, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, be condensed into thick paste, appropriate soak is in healing on wound.
Embodiment 2, crude drug weight proportion: 10 parts of Radix Tylophorae arenicolaes, 6 parts of Semen Aesculies, 3 parts of Lignum Pini Nodis, go back 6 parts, bobbin, 3 parts of Semen Litchis, 6 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 6 parts of Rhizoma Paridis, 6 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 6 parts of Cortex erythrinaes, 1 part, emplastra sinapis powder, 3 parts of Magnetitums, 10 parts of Radix Puerariaes.
Embodiment 3, crude drug weight proportion: 20 parts of Radix Tylophorae arenicolaes, 10 parts of Semen Aesculies, 6 parts of Lignum Pini Nodis, go back 10 parts, bobbin, 6 parts of Semen Litchis, 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 10 parts of Rhizoma Paridis, 10 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 10 parts of Cortex erythrinaes, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
Embodiment 4, crude drug weight proportion: 30 parts of Radix Tylophorae arenicolaes, 12 parts of Semen Aesculies, 10 parts of Lignum Pini Nodis, go back 12 parts, bobbin, 10 parts of Semen Litchis, 12 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 12 parts of Rhizoma Paridis, 12 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 12 parts of Cortex erythrinaes, 5 parts, emplastra sinapis powder, 10 parts of Magnetitums, 25 parts of Radix Puerariaes.
The Chinese medicine of embodiment 2～4 can be prepared from by following method:
(1) Semen Aesculi, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Lignum Pini Nodi, Semen Litchi coarse powder are extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting;
(2) emplastra sinapis powder, Magnetitum, Radix Puerariae were pulverized respectively to 150 mesh sieves, and became fine powder standby;
(3) Radix Tylophorae arenicolae, go back bobbin, Rhizoma Paridis, Cortex erythrinae, Potiria pectinifera (Mukller et Tro Sehel) and mix and add 10 times of water yields, decoct with water 2 times, each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3～4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get precipitation, spraying is dry, draws just material;
(4) gained volatile oil in step 1 is sprayed in the first material of step 3 gained, add gained fine powder in step 2 to mix, cross 60 mesh sieves, sterilizing, subpackage form.
During use, with warm water, dress the wound place after healing.
Effective combination of said medicine, coordinates mutually, effectively reach treatment and lancinate and hinder the object that wound does not feel like oneself after suture, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method
1.1 object
1.1.1 case selection: lancinate and hinder uncomfortable 89 examples of the former wound of the postoperative primary healing patient main suit of debridement and suturing a year August in June, 2011～2013, main suit's discomfort comprises local pain, fiber crops, itches, referred pain, formication, companion or do not accompany wound surrounding tissue to harden.Trunk wound 36 examples wherein, extremity wound 52 examples.Be divided into matched group 30 examples, thick paste group 29 examples and dress group 30 examples.Before three groups of patient treatments, on sex, age, incision wound distribute, compare, difference not statistically significant (P>0.05), has comparability.
1.1.2 inclusive criteria is: 1. lancinate wound between 1～10cm, without other complication; 2. the postoperative wound primary healing of debridement and suturing; 3. in postoperative three months of debridement and suturing; Wound part is without red and swollen heat pain, and gets rid of deep layer and infect; 4. non-diabetic and mental sickness medical history.
1.2 method
1.2.1 Therapeutic Method: matched group is embrocated with safflower oil part, 2 times/d.Thick paste group with the local appropriate soak of gained thick paste in the embodiment of the present invention 1 in healing on wound, 2 times/d.Dress group and dress in healing on wound with the local appropriate warm water of gained medicated powder in the embodiment of the present invention 2,2 times/d.3 groups of treatments all be take 14 days as 1 course for the treatment of, after the course for the treatment of, add up curative effect.
1.2.2 criterion of therapeutical effect: recovery from illness: clinical symptoms, sign disappear; Effective: clinical symptoms, sign turn for the better by and large, no longer impact life; Effective: clinical symptoms, sign alleviate, but sleep or life still can be affected; Invalid: clinical symptoms, sign are unchanged.
1.2.3 statistical analysis: SPSS13.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results
2.1 3 groups of Comprehensive Clinical curative effects comparison: thick paste group is organized cure rate and extremely obvious (the thick paste group χ of matched group difference with dressing
2=9.81, P<0.05; Dress group χ
2=9.31, P<0.05), thick paste group is organized total effective rate apparently higher than matched group (thick paste group χ with dressing
2=4.54, P<0.05; Dress group χ
2=6.67, P<0.05), see the following form.
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate |
| Matched group | 30 | 2(6.67%) | 8(26.67%) | 10(33.33%) | 10(33.33%) | 67.67% |
| Thick paste group | 29 | 12(41.38%) | 9(31.03%) | 6(20.69%) | 3(10.34%) | 93.10% |
| Dress group | 30 | 12(40.00%) | 10(33.33%) | 6(20.00%) | 2(6.67%) | 93.33% |
2.2 3 groups of adverse reactions of patients incidence rates: three groups all do not occur obvious adverse reaction.
3. conclusion
This result of study shows, use thick paste group of the present invention and dress group cure rate and total effective rate apparently higher than matched group, illustrate the present invention after treatment suture, healed wound have aspect doing not feel like oneself untoward reaction gently, the higher advantage of safety.
Claims (2)
1. improvement is lancinated and is hindered a Local Nursing Care thing uncomfortable after wound healing, it is characterized in that being prepared from by the crude drug of following weight proportion: 10～30 parts of Radix Tylophorae arenicolaes, 6～12 parts of Semen Aesculies, 3～10 parts of Lignum Pini Nodis, go back 6～12 parts, bobbin, 3～10 parts of Semen Litchis, 6～12 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 6～12 parts of Rhizoma Paridis, 6～12 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 6～12 parts of Cortex erythrinaes, 1～5 part, emplastra sinapis powder, 3～10 parts of Magnetitums, 10～25 parts of Radix Puerariaes.
2. a kind of improvement according to claim 1 is lancinated and is hindered Local Nursing Care thing uncomfortable after wound healing, it is characterized in that being prepared from by the crude drug of following weight proportion: 20 parts of Radix Tylophorae arenicolaes, 10 parts of Semen Aesculies, 6 parts of Lignum Pini Nodis, go back 10 parts, bobbin, 6 parts of Semen Litchis, 10 parts of Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae)s, 10 parts of Rhizoma Paridis, 10 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 10 parts of Cortex erythrinaes, 2 parts, emplastra sinapis powder, 6 parts of Magnetitums, 20 parts of Radix Puerariaes.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920055A (en) * | 2014-05-04 | 2014-07-16 | 王晖 | Lung protection drug used in perioperative period |
| CN103948810A (en) * | 2014-05-04 | 2014-07-30 | 青岛市中心医院 | Preparation method of preoperative intervention drug for thoracotomy |
| CN103948811A (en) * | 2014-05-04 | 2014-07-30 | 青岛市中心医院 | Preoperative intervention drug for thoracotomy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642531A (en) * | 2009-06-15 | 2010-02-10 | 张继成 | Capsule for strengthening spleen and lung and reducing blood sugar |
| CN101642542A (en) * | 2009-06-15 | 2010-02-10 | 张继成 | Capsule for nourishing liver and kidney and reducing blood pressure |
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2013
- 2013-12-31 CN CN201310752220.5A patent/CN103656244B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642531A (en) * | 2009-06-15 | 2010-02-10 | 张继成 | Capsule for strengthening spleen and lung and reducing blood sugar |
| CN101642542A (en) * | 2009-06-15 | 2010-02-10 | 张继成 | Capsule for nourishing liver and kidney and reducing blood pressure |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103920055A (en) * | 2014-05-04 | 2014-07-16 | 王晖 | Lung protection drug used in perioperative period |
| CN103948810A (en) * | 2014-05-04 | 2014-07-30 | 青岛市中心医院 | Preparation method of preoperative intervention drug for thoracotomy |
| CN103948811A (en) * | 2014-05-04 | 2014-07-30 | 青岛市中心医院 | Preoperative intervention drug for thoracotomy |
| CN103948811B (en) * | 2014-05-04 | 2016-05-18 | 青岛市中心医院 | The preoperative intervention medicine of a kind of open chest surgery |
| CN103920055B (en) * | 2014-05-04 | 2016-08-10 | 杜海英 | The lung preversation medicine that a kind of peri-operation period uses |
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