CN105250651A - Traditional Chinese medicine oral preparation for treating pregnancy syndromes and preparation method thereof - Google Patents
Traditional Chinese medicine oral preparation for treating pregnancy syndromes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine oral preparation for treating pregnancy syndromes and a preparation method thereof. The traditional Chinese medicine oral preparation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20 parts of Chinese date, 10-20 parts of Chinese dodder seed, 10-20 parts of cowrie shell, 8-16 parts of largehead atractylodes rhizome, 8-16 parts of dogbane leaf, 5-15 parts of Arabian jasmine flower, 5-15 parts of lily, 4-12 parts of finger citron, 4-12 parts of ginseng, 2-8 parts of perilla stem, 2-8 parts of baical skullcap root and 2-8 parts of donkey-hide glue. The traditional Chinese medicine oral preparation for treating the pregnancy syndromes, disclosed by the invention, adopts common traditional Chinese medicinal materials as raw materials, is scientific in formula and low in cost, is convenient to take, relatively quick takes effect, is significant in curative effect, does not have side effects, has the effects of benefiting qi and nourishing blood, preventing miscarriage and tonifying kidney, clearing heat and relieving fidgetness, soothing liver and relieving depression, as well as relieving pain and soothing nerves, and can be used for treating the pregnancy syndromes effectively.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of oral preparation of Chinese traditional medicinal for the treatment of pregnancy syndrome and preparation method thereof.
Background technology
Pregnancy syndrome, is commonly called as " pregnancy period syndrome ", is a kind of pregnancy period disease caused primarily of non-pathological factor.Its symptom primarily shows as insomnia, manic, anxiety, sensitive, suspicious etc., and severe patient there will be phenomenon and the behaviors such as dizziness, gestational hypertension, depression, irritability.
This onste mainly contains the reason of two aspects: be physiological reason on the one hand, is because the endocrine Pathophysiology change of anemia of pregnant woman's hypothalamic pituitary gonadal axis causes; On the other hand because health change brings psychological problems to cause, such as uncomfortable, think oneself become ugly, worry husband dislike and avoid, long-term pregnancy syndrome, not only can affect orthobiosis of anemia of pregnant woman and healthy, also can cause have a strong impact on foetus health.
Because Western medicine has certain side effect, therefore usually do not advocate to use Western medicine to the treatment of pregnancy syndrome patient, avoid affecting fetus.The traditional Chinese medical science is thought, pregnancy syndrome duty in the dirty functional disorder of liver,spleen,kidney three.Deficiency of spleen-YANG and kidneyYANG, water-damp not being transformed, general in flesh table; Or how depressed element is, functional activity of QI being not smooth, pregnant rear carcass is gradually long in addition, hinders ascending or descending movement of vital Qi, and the stagnation of QI is wet stops, and overflow in skin and send out as edema, this is edema during pregnancy.Visceral-qi deficiency in origin, under the cloudy blood of pregnant rear parent, fetus nourishing is appointed in poly-punching, and cloudy point must be lost, and the moon is YANG hyperactivity suppressing not, and liver-yang is partially high, above disturbs key clearly; Or after mid trimester of pregnancy, carcass is gradually large, affects ascending or descending movement of vital Qi, stagnation of QI benefit very, strongly fragrant and heat-transformation, heat disturbs the mind, then makes vexed; The stagnation of QI violates spleen, insufficiency of the spleen wet poly-, turns to expectorant turbid, liver-yang hold under the arm expectorant turbid on disturb key clearly and then occur the vertigo, headache, blurring of vision, this is vertigo in pregnancy.If cloudy blood deficiency very, excessive rising of liver-YANG, liver-wind stirring up internally; Or folder phlegm-fire is disturbed, hoodwink key clearly, and have wind symptom, twitch and send out as eclamposia.Primary disease is deficient with internal organs, deficiency of YIN-blood is this, and wind, fire, expectorant, the stasis of blood are mark.In existing patent application document, application publication number CN104547928A(application number: Chinese patent literature 201510006675.1) discloses a kind of Chinese medicine composition for the treatment of pregnancy syndrome, the crude drug chosen and composition by weight thereof be respectively: Concha Haliotidis 30-50 gram, Fructus Lycii 20-30 gram, Radix Paeoniae Alba 10-20 gram, Ramulus Uncariae Cum Uncis 10-20 gram, Radix Curcumae 10-20 gram, Concretio Silicea Bambusae 10-20 gram, Dens Draconis 10-20 gram, Poria 10-20 gram, Pericarpium Arecae 10-20 gram, certain herbaceous plants with big flowers 8-15 gram, Radix Linderae 8-12 gram, Fructus Chaenomelis 8-12 gram, Herba Aristolochiae 8-12 gram, Rhizoma Dioscoreae 8-12 gram, Caulis Akebiae 8-12 gram, Bulbus Fritillariae Uninbracteatae 8-12 gram.
Although there has been some Chinese medicines in treatment pregnancy syndrome product, also there is series of problems: curative effect is not remarkable, and the shortcomings such as Time of Administration is longer, make anemia of pregnant woman's compliance poor, therefore need to be further improved.
Summary of the invention
An object of the present invention overcomes the deficiencies in the prior art, provides one to prepare simply, drug effect rapidly, the oral preparation of Chinese traditional medicinal for the treatment of pregnancy syndrome that has no side effect.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:
Treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, take off the raw material of Chinese medicine stating weight proportion and be prepared from: Fructus Jujubae 10-20 part, Semen Cuscutae 10-20 part, Concha Erosariae seu Cypraeae 10-20 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Folium Apocyni Veneti 8-16 part, Flos Jasmini Sambac 5-15 part, Bulbus Lilii 5-15 part, Fructus Citri Sarcodactylis 4-12 part, Radix Ginseng 4-12 part, Caulis Perillae 2-8 part, Radix Scutellariae 2-8 part, Colla Corii Asini 2-8 part.
A kind of oral preparation of Chinese traditional medicinal for the treatment of pregnancy syndrome, preferred scheme, takes off the raw material of Chinese medicine stating weight proportion and is prepared from: Fructus Jujubae 13-17 part, Semen Cuscutae 13-17 part, Concha Erosariae seu Cypraeae 13-17 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Folium Apocyni Veneti 10-14 part, Flos Jasmini Sambac 8-12 part, Bulbus Lilii 8-12 part, Fructus Citri Sarcodactylis 6-10 part, Radix Ginseng 6-10 part, Caulis Perillae 4-6 part, Radix Scutellariae 4-6 part, Colla Corii Asini 4-6 part.
A kind of oral preparation of Chinese traditional medicinal for the treatment of pregnancy syndrome, preferred scheme, takes off the raw material of Chinese medicine stating weight proportion and is prepared from: 15 parts, Fructus Jujubae, Semen Cuscutae 15 parts, Concha Erosariae seu Cypraeae 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Apocyni Veneti 12 parts, Flos Jasmini Sambac 10 parts, Bulbus Lilii 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Ginseng 8 parts, Caulis Perillae 5 parts, Radix Scutellariae 5 parts, 5 parts, Colla Corii Asini.
Another object of the present invention is to provide the preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome.
Treat a preparation method for the oral preparation of Chinese traditional medicinal of pregnancy syndrome, step is as follows:
Step one: Colla Corii Asini is added in the water of 1.5-2.5 times of quality, then heating under 85-95 DEG C of condition, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add raw material weight 3-7 water soaking 30-50 minute doubly, then decoct with high heat to boiling, use slow fire instead to continue to decoct 40-60min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add raw material weight 2-4 water doubly, intense fire decocts to boiling, and slow fire continues to decoct 20-40min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat survey relative densities is 1.10-1.20, adding 2 times amount volume parts is the ethanol of 80%-90%, stir evenly, leave standstill, getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.30-1.40;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, Colla Corii Asini adds in the water of 1.8-2.2 times of quality by step one, and then heating under 88-92 DEG C of condition, stirring make it dissolve; Preferably, added by Colla Corii Asini in the water of 2 times of quality, then heating under 90 DEG C of conditions, stirring make it dissolve.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, step Acanthopanan trifoliatus (L.) Merr. raw material weight 4-6 water soaking 35-45 minute doubly, then decocts to boiling with high heat, uses slow fire instead and continues to decoct 45-55min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add raw material weight 2.5-3.5 water doubly, intense fire decocts to boiling, slow fire continues to decoct 25-35min, filters, obtains secondary decocting liquid; Preferably, add the water soaking 40 minutes of raw material weight 5 times, then decoct to boiling with high heat, use slow fire instead and continue to decoct 50min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 3 times, intense fire decocts to boiling, slow fire continues to decoct 30min, filters, obtains secondary decocting liquid.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, it is 1.13-1.17 that filtrate in step 3 is evaporated to 85 DEG C of heat survey relative densities by step 4, add the ethanol of 2 times amount 83%-87%, stir evenly, leave standstill, getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.34-1.36; Preferably, the filtrate in step 3 being evaporated to 85 DEG C of heat, to survey relative densities be 1.15, and add the ethanol of 2 times amount 85%, stir evenly, leave standstill, getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.35.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Jujubae: warm in nature, sweet in the mouth.Return spleen channel, stomach warp, heart channel.Effect and effect: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.Belong to the Qi-tonifying drug of qi-restoratives medicine subordinate classification.With controlling insufficiency of the spleen lack of appetite, qi-blood-body fluid deficiency, weak loose stool, married woman are dirty dry.There is physical strength reinforcing, resisting fatigue, tranquillizing and allaying excitement, protect the liver, increase leukocyte cAMP, strengthen the functions such as immunity and antiallergic action.
Semen Cuscutae: property is put down, acrid in the mouth, sweet.Return liver, kidney channel.Effect and effect: the kidney invigorating and essence nourishing, nourishing the liver tomorrow.For lumbago due to renal deficiency, sexual impotence, premature ejaculation, turbid urine, leukorrhagia, frequent micturition; Frequent fetal movement, threatened abortion; Deficiency of the liver and kindey, blurring of vision, visual deterioration.
Concha Erosariae seu Cypraeae: property is put down, salty in the mouth.Return Liver Channel.Effect and effect: tranquillizing the mind by relieving convulsion, suppressing the hyperactive liver improving eyesight.Belong to the suppressing liver-YANG medicine of medicine for calming liver and calming endopathic wind subordinate classification.With controlling, infantile hyperpyrexia is twitched, is had a dizzy spell, palpitate with fear vexed, insomnia and dreamful sleep, conjunctival congestion and swelling pain, pyretic toxicity corneal nebula.
The Rhizoma Atractylodis Macrocephalae: warm in nature, sweet in the mouth, hardship.Return spleen channel, stomach warp.Effect and effect: spleen invigorating, QI invigorating, dampness diuretic, hidroschesis, antiabortive.With controlling deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, have loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea are uneasy.
Folium Apocyni Veneti: cool in nature, sweet in the mouth, hardship.Return Liver Channel.Effect and effect: suppressing the hyperactive liver is calmed the nerves, clearing away heat and promoting diuresis.With controlling dizziness due to hyperactivity of liver-YANG, palpitation and insomnia, edema oliguria, hypertension, neurasthenia, nephritis edema.
Flos Jasmini Sambac: warm in nature, acrid in the mouth, micro-sweet.Return spleen channel, stomach warp, Liver Channel.Effect and effect: regulating QI to relieve pain, ward off dirty dissipating depression of QI.Belong to QI regulating medicine.Cure mainly turbid damp obstructing in middle-JIAO, chest and diaphragm does not relax, and dysentery is suffered from abdominal pain, dizziness headache, conjunctival congestion, sore.
Bulbus Lilii: cold in nature, sweet in the mouth.GUIXIN warp, lung meridian.Effect and effect: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.With controlling deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency palpitation with fear, insomnia and dreamful sleep, absentminded.Cough due to wind and cold, Deficiency and coldness of spleen and stomach, stool lingering diarrhea person avoid clothes.
Fructus Citri Sarcodactylis: warm in nature, acrid in the mouth, hardship, acid.Return lung meridian, spleen channel, Liver Channel.Effect and effect: liver-smoothing, qi-regulating and stomach and alleviating pain.Belong to QI regulating medicine.With controlling stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, lack of appetite vomiting.
Radix Ginseng: warm in nature, sweet in the mouth, micro-hardship.GUIXIN warp, lung meridian, spleen channel, kidney channel.Effect and effect: strongly invigorating primordial QI, multiple arteries and veins are admittedly de-, invigorating the spleen to benefit the lung, promoting the production of body fluid and inducing sedation of the mind.Treatment weak body and prostration, dyspnea with shortness of breath, spontaneous perspiration and cold extremities, tired mind, lack of appetite and vomiting, dyspnea due to deficiency of vital energy or chronic cough, thirst due to body fluid deficiency, quench one's thirst, insomnia and dreamful sleep, palpitation with fear are forgetful, sexual impotence, frequent micturition, all qi-blood-body fluid deficiencies disease.Radix Ginseng has the effects such as two-ways regulation, nootropics, analgesia, antipyretic, anti-frightened and muscular strength weaken to central nervous system.The effect such as heart tonifying, ischemia resisting, blood vessel dilating, blood pressure lowering is had to cardiovascular system; Protection and hemopoietic function is had to blood system, and anticoagulation and antithrombotic; Endocrine system has corticotropin sample, short gonadotropic Effect.
Caulis Perillae: warm in nature, acrid in the mouth.Return lung meridian, spleen channel.Effect and effect: regulating the flow of QI to ease the stomach, pain relieving, antiabortive.Belong to QI regulating medicine.With controlling, chest and diaphragm painful abdominal mass is vexed, gastralgia, heating installation are vomitted, frequent fetal movement.
Radix Scutellariae: cold in nature, bitter in the mouth.Return lung meridian, gallbladder meridian, spleen channel, large intestine channel, small intestine meridian.Effect and effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.Belong to the heat clearing and dampness removing medicine of antipyretic subordinate classification.With controlling hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tell nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Colla Corii Asini: property is put down, sweet in the mouth.Return lung meridian, Liver Channel, kidney channel.Effect and effect: YIN nourishing of enriching blood, moisturize, stop blooding.Belong to the hematonic of qi-restoratives medicine subordinate classification., dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency unable for blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity, xeropulmonary cough, chronic cough spitting of blood, hematuria of spitting blood, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
With prior art ratio, beneficial effect of the present invention is:
The present invention treats the oral preparation of Chinese traditional medicinal of pregnancy syndrome, adopt common Chinese medicine material as raw material, scientific formulation, with low cost, taking convenience, proves effective very fast, evident in efficacy, have no side effect, there is benefiting qi and nourishing blood, effect that antiabortive the kidney invigorating, clearing heat and relieving fidgetness, dispersing the stagnated live-QI to relieve the stagnation of QI, pain relieving are calmed the nerves, effectively can treat pregnancy syndrome.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): 10 parts, Fructus Jujubae, Semen Cuscutae 10 parts, Concha Erosariae seu Cypraeae 10 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Folium Apocyni Veneti 8 parts, Flos Jasmini Sambac 5 parts, Bulbus Lilii 5 parts, Fructus Citri Sarcodactylis 4 parts, Radix Ginseng 4 parts, Caulis Perillae 2 parts, Radix Scutellariae 2 parts, 2 parts, Colla Corii Asini.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, step is as follows:
Step one: Colla Corii Asini is added in the water of 1.5 times of quality, then heating under 85 DEG C of conditions, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add the water soaking 30 minutes of raw material weight 3 times, then decoct with high heat to boiling, use slow fire instead to continue to decoct 40min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add the water of raw material weight 2 times, intense fire decocts to boiling, and slow fire continues to decoct 20min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat, to survey relative densities be 1.10, and adding 2 times amount volume parts is the ethanol of 80%, stirs evenly, and leaves standstill, and getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.30;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
embodiment 2treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): 20 parts, Fructus Jujubae, Semen Cuscutae 20 parts, Concha Erosariae seu Cypraeae 20 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Folium Apocyni Veneti 16 parts, Flos Jasmini Sambac 15 parts, Bulbus Lilii 15 parts, Fructus Citri Sarcodactylis 12 parts, Radix Ginseng 12 parts, Caulis Perillae 8 parts, Radix Scutellariae 8 parts, 8 parts, Colla Corii Asini.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, step is as follows:
Step one: Colla Corii Asini is added in the water of 2.5 times of quality, then heating under 95 DEG C of conditions, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add the water soaking 50 minutes of raw material weight 7 times, then decoct with high heat to boiling, use slow fire instead to continue to decoct 60min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add the water of raw material weight 4 times, intense fire decocts to boiling, and slow fire continues to decoct 40min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat, to survey relative densities be 1.20, and adding 2 times amount volume parts is the ethanol of 90%, stirs evenly, and leaves standstill, and getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.40;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
embodiment 3treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): 13 parts, Fructus Jujubae, Semen Cuscutae 13 parts, Concha Erosariae seu Cypraeae 13 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Folium Apocyni Veneti 10 parts, Flos Jasmini Sambac 8 parts, Bulbus Lilii 8 parts, Fructus Citri Sarcodactylis 6 parts, Radix Ginseng 6 parts, Caulis Perillae 4 parts, Radix Scutellariae 4 parts, 4 parts, Colla Corii Asini.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, step is as follows:
Step one: Colla Corii Asini is added in the water of 1.8 times of quality, then heating under 88 DEG C of conditions, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add the water soaking 35 minutes of raw material weight 4 times, then decoct with high heat to boiling, use slow fire instead to continue to decoct 45min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add the water of raw material weight 2.5 times, intense fire decocts to boiling, and slow fire continues to decoct 25min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat, to survey relative densities be 1.13, and adding 2 times amount volume parts is the ethanol of 83%, stirs evenly, and leaves standstill, and getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.34;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
embodiment 4treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): 17 parts, Fructus Jujubae, Semen Cuscutae 17 parts, Concha Erosariae seu Cypraeae 17 parts, the Rhizoma Atractylodis Macrocephalae 14 parts, Folium Apocyni Veneti 14 parts, Flos Jasmini Sambac 12 parts, Bulbus Lilii 12 parts, Fructus Citri Sarcodactylis 10 parts, Radix Ginseng 10 parts, Caulis Perillae 6 parts, Radix Scutellariae 6 parts, 6 parts, Colla Corii Asini.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, step is as follows:
Step one: Colla Corii Asini is added in the water of 2.2 times of quality, then heating under 92 DEG C of conditions, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add the water soaking 45 minutes of raw material weight 6 times, then decoct with high heat to boiling, use slow fire instead to continue to decoct 55min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add the water of raw material weight 3.5 times, intense fire decocts to boiling, and slow fire continues to decoct 35min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat, to survey relative densities be 1.17, and adding 2 times amount volume parts is the ethanol of 87%, stirs evenly, and leaves standstill, and getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.36;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
embodiment 5treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, take off the raw material of Chinese medicine stating weight proportion and be prepared from (getting 1g for every part): 15 parts, Fructus Jujubae, Semen Cuscutae 15 parts, Concha Erosariae seu Cypraeae 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Apocyni Veneti 12 parts, Flos Jasmini Sambac 10 parts, Bulbus Lilii 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Ginseng 8 parts, Caulis Perillae 5 parts, Radix Scutellariae 5 parts, 5 parts, Colla Corii Asini.
The preparation method of the oral preparation of Chinese traditional medicinal of above-mentioned treatment pregnancy syndrome, step is as follows:
Step one: Colla Corii Asini is added in the water of 2 times of quality, then heating under 90 DEG C of conditions, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add the water soaking 40 minutes of raw material weight 5 times, then decoct with high heat to boiling, use slow fire instead to continue to decoct 50min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add the water of raw material weight 3 times, intense fire decocts to boiling, and slow fire continues to decoct 30min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat, to survey relative densities be 1.15, and adding 2 times amount volume parts is the ethanol of 85%, stirs evenly, and leaves standstill, and getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.35;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
Clinical laboratory data:
Oral preparation of Chinese traditional medicinal of the present invention is in March, 2012 to 2015 year JIUYUE clinical observation pregnancy syndrome patient 200 example, and clinical report is as follows:
1, physical data: in 200 routine patients, the oldest person 43 years old, reckling 24 years old, 33 years old mean age.
2, Therapeutic Method: taking oral preparation of Chinese traditional medicinal prepared by the embodiment of the present invention 5, every day two bags, getting up early and respectively take a bag before sleeping, 3 days was 1 course for the treatment of.
3, criterion of therapeutical effect: cure: vomiting stops, insomnia, clinical symptom disappearance, continuous 3 times of the urine ketoboidies inspection such as irascible, blood pressure is high; Effective: clinical symptom reliefs such as vomitting, have a sleepless night, irascible, blood pressure is high, continuous 3 feminine genders of urine ketoboidies inspection, ultrasound diagnosis fetal development is normal, recurs after drug withdrawal; Invalid: clinical symptoms is without improvement.
4, therapeutic outcome: cure 175 examples, effective 21 examples, invalid 4 examples, cure rate is 87.5%, and total effective rate is 98%.In therapeutic process, all there is not obvious adverse reaction in 200 routine patients.Follow-up observation through the patient of Drug therapy of the present invention, none routine neonatal death.
model case
Case 1: king xx, female, 28 years old, there is two lower limbs edema in patient, normal companioned with headache, dizziness before 1 year.Dizziness of having a headache after 2 months obviously increases the weight of, blood pressure 145/100mmHg, is " pregnancy syndrome, gestation hypertension " in hospital diagnosis.Doctor gives the treatment of the oral preparation of Chinese traditional medicinal in the embodiment of the present invention 5, and after taking 1 course for the treatment of, headache, dizziness alleviate, and blood pressure is normal, and after continuing to take 2 courses for the treatment of, recovery from illness, without recurrence, the healthy boy baby of mature rear natural labor one, after the birth, mother and child were doing well.
Case 2: cattle xx, female, 31 years old, patient started after conceived 5 months to occur the symptom such as insomnia, suspicious, irritated, easy fatigue, emotion big rise and fall.Examination in hospital for this symptom be because carcass is gradually large, affecting ascending or descending movement of vital Qi causes the stagnation of QI raw strongly fragrant, and the pregnancy syndrome of initiation, considers foetus health, give the treatment of the oral preparation of Chinese traditional medicinal in the embodiment of the present invention 5, after taking 1 course for the treatment of, above-mentioned symptom makes moderate progress, after continuing to take 1 course for the treatment of, insomnia, the symptom such as suspicious, irritated disappear completely, emotion is steady, recovery from illness, 3 month in and month out after produce a healthy girl baby smoothly.
Claims (9)
1. treat an oral preparation of Chinese traditional medicinal for pregnancy syndrome, it is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: Fructus Jujubae 10-20 part, Semen Cuscutae 10-20 part, Concha Erosariae seu Cypraeae 10-20 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Folium Apocyni Veneti 8-16 part, Flos Jasmini Sambac 5-15 part, Bulbus Lilii 5-15 part, Fructus Citri Sarcodactylis 4-12 part, Radix Ginseng 4-12 part, Caulis Perillae 2-8 part, Radix Scutellariae 2-8 part, Colla Corii Asini 2-8 part.
2. a kind of oral preparation of Chinese traditional medicinal for the treatment of pregnancy syndrome according to claim 1, is characterized in that: take off the raw material of Chinese medicine stating weight proportion and be prepared from: 15 parts, Fructus Jujubae, Semen Cuscutae 15 parts, Concha Erosariae seu Cypraeae 15 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Folium Apocyni Veneti 12 parts, Flos Jasmini Sambac 10 parts, Bulbus Lilii 10 parts, Fructus Citri Sarcodactylis 8 parts, Radix Ginseng 8 parts, Caulis Perillae 5 parts, Radix Scutellariae 5 parts, 5 parts, Colla Corii Asini.
3. a preparation method for the oral preparation of Chinese traditional medicinal of the treatment pregnancy syndrome according to any one of claim 1-2, is characterized in that: step is as follows:
Step one: Colla Corii Asini is added in the water of 1.5-2.5 times of quality, then heating under 85-95 DEG C of condition, stirring make it dissolve;
Step 2: by Fructus Jujubae (pitted), Radix Ginseng cleaning, drying, after pulverizing, crosses 100 mesh sieves, obtains fine powder;
Step 3: Semen Cuscutae, Concha Erosariae seu Cypraeae, the Rhizoma Atractylodis Macrocephalae, Folium Apocyni Veneti, Flos Jasmini Sambac, Bulbus Lilii, Fructus Citri Sarcodactylis, Caulis Perillae, Radix Scutellariae are cleaned, after section, be placed in marmite, add raw material weight 3-7 water soaking 30-50 minute doubly, then decoct with high heat to boiling, use slow fire instead to continue to decoct 40-60min, filter, leach medicinal residues, obtain decocting liquid first, then in filtering residue, add raw material weight 2-4 water doubly, intense fire decocts to boiling, and slow fire continues to decoct 20-40min, filter, obtain secondary decocting liquid, merge twice decocting liquid, obtain filtrate;
Step 4: the filtrate in step 3 being evaporated to 85 DEG C of heat survey relative densities is 1.10-1.20, adding 2 times amount volume parts is the ethanol of 80%-90%, stir evenly, leave standstill, getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.30-1.40;
Step 5: the fine powder that the Colla Corii Asini clear paste of step 4 and step one dissolved, step 2 obtain mixes, and adds the sucrose of its weight 70%, after stirring and evenly mixing, dry, pulverize 40 mesh sieves, made granule, and packaging, obtains oral preparation of Chinese traditional medicinal.
4. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of pregnancy syndrome according to claim 3, is characterized in that: Colla Corii Asini adds in the water of 1.8-2.2 times of quality by step one, and then heating under 88-92 DEG C of condition, stirring make it dissolve.
5. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of pregnancy syndrome according to claim 4, is characterized in that: Colla Corii Asini adds in the water of 2 times of quality by step one, and then heating under 90 DEG C of conditions, stirring make it dissolve.
6. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of pregnancy syndrome according to claim 3, it is characterized in that: step Acanthopanan trifoliatus (L.) Merr. raw material weight 4-6 water soaking 35-45 minute doubly, then decocts to boiling with high heat, use slow fire instead and continue to decoct 45-55min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add raw material weight 2.5-3.5 water doubly, intense fire decocts to boiling, slow fire continues to decoct 25-35min, filters, obtains secondary decocting liquid.
7. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of pregnancy syndrome according to claim 6, it is characterized in that: the water soaking of step Acanthopanan trifoliatus (L.) Merr. raw material weight 5 times 40 minutes, then decoct to boiling with high heat, use slow fire instead and continue to decoct 50min, filter, leach medicinal residues, obtain decocting liquid first, in filtering residue, then add the water of raw material weight 3 times, intense fire decocts to boiling, slow fire continues to decoct 30min, filters, obtains secondary decocting liquid.
8. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of pregnancy syndrome according to claim 3, it is characterized in that: it is 1.13-1.17 that the filtrate in step 3 is evaporated to 85 DEG C of heat survey relative densities by step 4, add the ethanol of 2 times amount 83%-87%, stir evenly, leave standstill, getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.34-1.36.
9. a kind of preparation method for the treatment of the oral preparation of Chinese traditional medicinal of pregnancy syndrome according to claim 8, it is characterized in that: it is 1.15 that the filtrate in step 3 is evaporated to 85 DEG C of heat survey relative densities by step 4, add the ethanol of 2 times amount 85%, stir evenly, leave standstill, getting relative density when supernatant reclaims ethanol and is concentrated into 85 DEG C is the clear paste of 1.35.
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Application publication date: 20160120 |