CN105250631A - Medicine for treating type 2 diabetes mellitus and preparation method thereof - Google Patents

Abstract

The invention provides a medicine for treating type 2 diabetes mellitus. The medicine is prepared from radix rehmanniae preparata, Chinese yam, cornus pulp, radix rehmanniae recen, radix scrophulariae, radix paeoniae rubra, radix paeoniae alba, fructus lycii, angelica sinensis, rhizoma anemarrhenae, cortex phellodendri, cistanche salsa and licorice root. The medicine has the advantages of few medicinal ingredients and good curative effect, has the effects of tonifying qi, nourishing yin, tonifying liver and kidneys, promoting secretion of body fluid, clearing heat and reducing blood glucose, can be used for effectively controlling blood glucose and urine glucose after being taken, repairing pancreas islet and enhancing the capabilities of islet secretion and blood glucose regulation, and follows the traditional Chinese medicine therapeutic principle of strengthening vital qi and eliminating pathogenic factors.

Description

A kind of medicine for the treatment of type 2 diabetes mellitus and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, especially a kind of medicine for the treatment of type 2 diabetes mellitus and preparation method thereof.

Background technology

Type 2 diabetes mellitus is again Adult Onset's patients with type Ⅰ DM, how the sequela of 35 ~ 40 years old, accounts for diabetics more than 90%.

The ability producing insulin in type 2 diabetes mellitus patient body not completely loses, in some patient bodies, insulin even produces too much, but the action effect of insulin is poor, the insulin therefore in patient body is a kind of shortage relatively, can be stimulated the secretion of insulin in body by some oral drugs.But still have some client need use of exogenous insulins to the later stage.

Main biguanides and the sulfonylureas drugs for diabetes of using is treated at present, makes the blood glucose of diabetics be able to temporary transient control.Reach tens of kinds for clinical treatment Chinese medicine and western medicine used at present, but owing to also not having substantial breakthrough so far to diabetes pathology, etiological study, treatment diabetes are still in and control blood glucose, glucose in urine increases the stage and prevents the conceptual phase of comprehensive complication.In addition, patient's long-term taking Western medicine, can bring side effect to internal organs such as kidney, liver, the heart, spleen, stomaches.CN101700354B discloses a kind of Chinese medicine for the treatment of diabetes, is made up of 20 taste Chinese medicines such as Radix Panacis Quinquefolii, the Rhizoma Anemarrhenae, Fructus Momordicae charantiae, Rhizoma Dioscoreaes.Described medicine also has good curative effect to type 2 diabetes mellitus.

Summary of the invention

Be applicable to medicine for the treatment of type 2 diabetes mellitus and preparation method thereof easily to obtain effective and safe, inventor through clinical and studies of pharmacy a large amount of for a long time, after having carried out the interaction between sufficient clinical verification and Chinese medicine, has completed the present invention to this.

The invention provides a kind of medicine for the treatment of type 2 diabetes mellitus, comprise Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, the Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Lycii, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Phellodendri, Herba Cistanches, Radix Glycyrrhizae.

Preferably, in described pharmaceutical composition, with parts by weight, its concrete constituent content is as follows:

Radix Rehmanniae Preparata 20-70 part, Rhizoma Dioscoreae 20-70 part, Fructus Corni 20-40 part, Radix Rehmanniae 20-70 part, Radix Scrophulariae 20-40 part, Radix Paeoniae Rubra 20-40 part, Radix Paeoniae Alba 20-40 part, Fructus Lycii 30-70 part, Radix Angelicae Sinensis 30-70 part, Rhizoma Anemarrhenae 10-20 part, Cortex Phellodendri 10-20 part, Herba Cistanches 15-30 part, Radix Glycyrrhizae 5-10 part.

Further, medicine of the present invention has optimum ratio to be:

60 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 60 parts, Fructus Corni 30 parts, 60 parts, the Radix Rehmanniae, Radix Scrophulariae 30 parts, Radix Paeoniae Rubra 30 parts, the Radix Paeoniae Alba 30 parts, Fructus Lycii 60 parts, Radix Angelicae Sinensis 60 parts, the Rhizoma Anemarrhenae 15 parts, Cortex Phellodendri 15 parts, Herba Cistanches 25 parts, 6 parts, Radix Glycyrrhizae.

Treat a medicine for type 2 diabetes mellitus as above, its preparation method is:

1), according to described weight portion take each component, add the decocting 2.5 ~ 3.5 hours of 13 ~ 17 times of weight, filter centrifugation removes slag, and is condensed into clear paste;

2), collect medicinal residues, add the decocting 1 hour of 10 times of weight, filter centrifugation removes medicinal residues, is condensed into clear paste;

3), by step 1) and step 2) in gained clear paste mixing, both described medicine.

Preferably, step 1) in add the water of 15 times of weight, first time extracts 1.5 hours.

Described process for preparing medicine can add medicine acceptable carrier conveniently technique, makes tablet, capsule, powder, pill, granule, soft capsule, drop pill, unguentum or oral liquid.

Wherein, the action and efficacy of major pharmaceutical component is:

Radix Rehmanniae Preparata: sweet, tepor.Return liver, kidney channel.To enrich blood yin nourishing, life essence-filling, marrow-benefitting.

Rhizoma Dioscoreae: sweet, flat, nontoxic.Return spleen, lung, kidney channel.Nourish strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.

Fructus Corni: sour, puckery, tepor.Liver and kidney tonifying, arresting seminal emission hidroschesis: the soreness of waist for deficiency of the liver and kindey is passed out semen, have a dizzy spell, menorrhagia and the disease such as frequent micturition, spontaneous perspiration.Control seminal emission and often join Fructus Rosae Laevigatae, Fructus Ligustri Lucidi; Control spontaneous perspiration due to yang insufficiency and often join Fructus Schisandrae Chinensis.

The Radix Rehmanniae: sweet, cold.GUIXIN, liver, kidney channel.

Radix Scrophulariae: clearing away heat and cooling blood; Nourishing YIN to lower pathogenic fire; Detoxicating and resolving stagnation of pathogens.Main warm febrile disease and nutrient blood; Fever of the body; Excessive thirst; Crimson tongue; Send out speckle; Hectic fever due to YIN-deficiency chronic cough; Fidgets due to deficiency is awake not; Constipation is hindered in Tianjin; Order is puckery dim-sighted; Throat larynx swells and ache; Scrofula sucutaneous nodule; Skin sore.

Radix Paeoniae Rubra: return Liver Channel.Clearing away heat and cooling blood, eliminating stasis to stop pain.For thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.

The Radix Paeoniae Alba: paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.Radix Paeoniae Alba decoct can suppress dysentery bacterium, streptococcus pneumoniae, escherichia coli, Bacillus typhi, Hemolytic streptococcus, bacillus pyocyaneus etc.

Fructus Lycii: sweet is flat.Bitter, sweet; Cool in nature.

Radix Angelicae Sinensis: return liver, the heart, spleen channel.Enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-; Metrorrhagia; Asthenia cold abdominalgia; Flaccidity syndrome and arthralgia syndrome; Numbness of the skin; Dryness of the intestine dyschezia; Heavy after bloody dysentery; Ulcer sores; Injury from falling down.

The Rhizoma Anemarrhenae: return lung, stomach, kidney channel.Clearing away heat-fire is nourshing Yin and drynsessmoistening prescription.Calentura excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, dryness of the intestine constipation.

Cortex Phellodendri: kidney, urinary bladder channel.Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.For damp-heat dysentery, jaundice dark coloured urine, leukorrhagia pudendal pruritus, the puckery pain of pyretic stranguria, beriberi flaccidity is knitted, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema eczema.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.

Herba Cistanches: sweet in the mouth; Salty; Warm in nature.Return kidney; Large intestine channel.Kidney-replenishing; Benefiting essence-blood; Intestine moistening road.Main kidney yang deficiency; The sexual impotence of asthenia of essence and blood; Seminal emission; Nebulousurine; The frequent micturition heeltap; Lumbago flaccidity of the lower limbs; Tinnitus order flower; Menstruation is spread out the phase; Infertility; Dryness of the intestine constipation.

Beneficial effect of the present invention:

A kind of medicine for the treatment of type 2 diabetes mellitus of the present invention, the drug component used is few, and good effect, has supplementing QI and nourishing YIN, the liver and the kidney tonifying, replenishing body fluid and clearing away heat pathogen, falls hypoglycemic effect, after taking, blood glucose, glucose in urine are effectively controlled, to islets of langerhans, there is repair, strengthen the secretion of insulin and the ability of blood glucose regulation, follow the double therapeutic principle of traditional Chinese medicine executed of strengthening vital QI to eliminate pathogenic factors.In method for the treatment of based on method, also to embody in eight therapeutic methods temperature, clear, disappear, applying in a flexible way of mending, ingenious prescription reach with in curative effect.Globality and the dialectical nature of hepatopathy are fully experienced in the legislation of we, prescription, square medicine, and formula is unique, and determined curative effect, without obvious toxic-side effects.

Detailed description of the invention

Below by specific embodiment, the present invention is described in detail; but the purposes of these exemplary embodiments and object are only used for exemplifying the present invention; not any type of any restriction is formed to real protection scope of the present invention, more non-protection scope of the present invention is confined to this.

Embodiment 1

Treat a medicine for type 2 diabetes mellitus, with parts by weight, its concrete constituent content is as follows:

20 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 20 parts, Fructus Corni 20 parts, 20 parts, the Radix Rehmanniae, Radix Scrophulariae 20 parts, Radix Paeoniae Rubra 20 parts, the Radix Paeoniae Alba 20 parts, Fructus Lycii 30 parts, Radix Angelicae Sinensis 30 parts, the Rhizoma Anemarrhenae 10 parts, Cortex Phellodendri 10 parts, Herba Cistanches 15 parts, 5 parts, Radix Glycyrrhizae.

Treat a medicine for type 2 diabetes mellitus as above, its preparation method is:

1), according to described weight portion take each component, add the decocting 2.5 ~ 3.5 hours of 13 ~ 17 times of weight, filter centrifugation removes slag, and is condensed into clear paste;

2), collect medicinal residues, add the decocting 1 hour of 10 times of weight, filter centrifugation removes medicinal residues, is condensed into clear paste;

3), by step 1) and step 2) in gained clear paste mixing, both described medicine.

Embodiment 2

Treat a medicine for type 2 diabetes mellitus disease, in described pharmaceutical composition, with parts by weight, its concrete constituent content is as follows:

70 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 70 parts, Fructus Corni 40 parts, 70 parts, the Radix Rehmanniae, Radix Scrophulariae 40 parts, Radix Paeoniae Rubra 40 parts, the Radix Paeoniae Alba 40 parts, Fructus Lycii 70 parts, Radix Angelicae Sinensis 70 parts, the Rhizoma Anemarrhenae 20 parts, Cortex Phellodendri 20 parts, Herba Cistanches 30 parts, 10 parts, Radix Glycyrrhizae.

Concrete preparation method is with embodiment 1.

Described medicine is prepared as oral liquid.

Embodiment 3

Treat a medicine for type 2 diabetes mellitus disease, in described pharmaceutical composition, with parts by weight, its concrete constituent content is as follows:

60 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 60 parts, Fructus Corni 30 parts, 60 parts, the Radix Rehmanniae, Radix Scrophulariae 30 parts, Radix Paeoniae Rubra 30 parts, the Radix Paeoniae Alba 30 parts, Fructus Lycii 60 parts, Radix Angelicae Sinensis 60 parts, the Rhizoma Anemarrhenae 15 parts, Cortex Phellodendri 15 parts, Herba Cistanches 25 parts, 6 parts, Radix Glycyrrhizae.

Concrete preparation method is with embodiment 1.

Described medicine is prepared as slow releasing tablet.

Embodiment 4:

Treat a medicine for type 2 diabetes mellitus disease, in described pharmaceutical composition, with parts by weight, its concrete constituent content is as follows:

40 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 50 parts, Fructus Corni 25 parts, 60 parts, the Radix Rehmanniae, Radix Scrophulariae 25 parts, Radix Paeoniae Rubra 25 parts, the Radix Paeoniae Alba 25 parts, Fructus Lycii 40 parts, Radix Angelicae Sinensis 40 parts, the Rhizoma Anemarrhenae 15 parts, Cortex Phellodendri 18 parts, Herba Cistanches 16 parts, 6 parts, Radix Glycyrrhizae.

Concrete preparation method is with embodiment 1.

Described medicine is prepared as granule.

Embodiment 5:

Treat a medicine for type 2 diabetes mellitus disease, in described pharmaceutical composition, with parts by weight, its concrete constituent content is as follows:

50 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 55 parts, Fructus Corni 35 parts, 50 parts, the Radix Rehmanniae, Radix Scrophulariae 35 parts, Radix Paeoniae Rubra 25 parts, the Radix Paeoniae Alba 25 parts, Fructus Lycii 55 parts, Radix Angelicae Sinensis 60 parts, the Rhizoma Anemarrhenae 16 parts, Cortex Phellodendri 18 parts, Herba Cistanches 25 parts, 6 parts, Radix Glycyrrhizae.

Concrete preparation method is with embodiment 1.

Described medicine is prepared as honeyed pill.

Clinical research and case:

Clinical research:

1. clinical data 1:

1.1 physical data: 70 routine type 2 diabetes mellitus patients, wherein male 32 example, women 38 example; In age 40-78 year, all derive from the department of Chinese medicine outpatient service of 2012.04 ~ 2014.12 the courts, the course of disease-2 years on the 1st.

1.2 diagnostic criterias: with reference to the diabetes etiology typing standard that the DiabetesCare magazine in July, 1997 is published, all diagnostic criterias meeting diabetes, namely the one that insulin release test result meets following condition is diagnosed as type 2 diabetes mellitus.1. with insulin resistant for main companion's relative insulin is not enough.2. insulin obviously lacks companion's insulin resistant.3. do not make a definite diagnosis person can not to do 1., 2..

Chinese medical discrimination diagnostic criteria: deficiency of both QI and YIN or double heat syndrome: (1) primary symptom: fatigue and weakness, thirst and liking drink, easy hungry polyphagia, frequent micturition.(2) secondary disease: dysphoria with feverish sensation in the chest palms and soles, spontaneous perspiration or night sweat, breathe hard lazy speech, cardiopalmus, constipation.(3) tongue arteries and veins: red tongue with a little fluid or corpulent tongue are large, thready pulse or count accurately.Indispensable 1 of above primary symptom, adds time disease 2, with reference to tongue arteries and veins and diagnosable.

1.3 inclusive criterias: 1. compound doctor trained in Western medicine or tcm diagnosis standard, the state of an illness is defined as type 2 diabetes mellitus after diagnosing; 2. .2 patients with type Ⅰ DM sick time is within 5 years, hospital stays >=4 weeks; 3.. patient age is in 20-80 year; 4.. add this research voluntarily.

1.4 exclusion standards: (1) gestation, women breast-feeding their children and have drug allergy history person.(2) person that has severe complication.(3) be unwilling cooperation and psychotic.(4) metabolism disorders such as diabetic ketoacidosis and severe infection person is had in nearly 1 month.(5) less than 4 weeks, namely viewing duration is not left hospital person.

2. method:

2.1 Therapeutic Method:

According to embodiment 3, conveniently technique, make slow releasing tablet.Prescription is as follows:

60 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 60 parts, Fructus Corni 30 parts, 60 parts, the Radix Rehmanniae, Radix Scrophulariae 30 parts, Radix Paeoniae Rubra 30 parts, the Radix Paeoniae Alba 30 parts, Fructus Lycii 60 parts, Radix Angelicae Sinensis 60 parts, the Rhizoma Anemarrhenae 15 parts, Cortex Phellodendri 15 parts, Herba Cistanches 25 parts, 6 parts, Radix Glycyrrhizae.

2.2 usings method:

Use medicine of the present invention, consumption is equivalent to potion on the one, divides and takes for 2 times.Within 30 days, be a course for the treatment of, statistics therapeutic effect, in table 1.

2.3 curative effect index:

With reference to version " new Chinese medicine guideline of clinical investigations " middle diabetes curative effect evaluation criteria in 2002.Computing formula: adopt nimodipine method: [before (before treating the rear integration of integration-treatment)/treatment integration] × 100%.

(1) effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%;

(2) effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%;

(3) invalid: tcm clinical practice symptom, sign are not improved, even increase the weight of, syndrome integral reduces <30%.

3. result:

Table 1.2 patients with type Ⅰ DM patient therapeutic outcome 70 example (%)

Conclusion: courses of pharmaceuticals of the present invention is short, instant effect, treats 3 courses for the treatment of, both 90 days time, effective percentage reaches 94.28%.

Claims (5)

1. treat a medicine for type 2 diabetes mellitus, comprise Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, the Radix Rehmanniae, Radix Scrophulariae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Fructus Lycii, Radix Angelicae Sinensis, the Rhizoma Anemarrhenae, Cortex Phellodendri, Herba Cistanches, Radix Glycyrrhizae.

2. a kind of medicine for the treatment of type 2 diabetes mellitus as claimed in claim 1, it is characterized in that, each component of described medicine according to parts by weight is: Radix Rehmanniae Preparata 20-70 part, Rhizoma Dioscoreae 20-70 part, Fructus Corni 20-40 part, Radix Rehmanniae 20-70 part, Radix Scrophulariae 20-40 part, Radix Paeoniae Rubra 20-40 part, Radix Paeoniae Alba 20-40 part, Fructus Lycii 30-70 part, Radix Angelicae Sinensis 30-70 part, Rhizoma Anemarrhenae 10-20 part, Cortex Phellodendri 10-20 part, Herba Cistanches 15-30 part, Radix Glycyrrhizae 5-10 part.

3. a kind of medicine for the treatment of type 2 diabetes mellitus as claimed in claim 1 or 2, it is characterized in that, each component of described medicine according to parts by weight is: 60 parts, Radix Rehmanniae Preparata, Rhizoma Dioscoreae 60 parts, Fructus Corni 30 parts, 60 parts, the Radix Rehmanniae, Radix Scrophulariae 30 parts, Radix Paeoniae Rubra 30 parts, the Radix Paeoniae Alba 30 parts, Fructus Lycii 60 parts, Radix Angelicae Sinensis 60 parts, the Rhizoma Anemarrhenae 15 parts, Cortex Phellodendri 15 parts, Herba Cistanches 25 parts, 6 parts, Radix Glycyrrhizae.

4. a kind of medicine for the treatment of type 2 diabetes mellitus as claimed in claim 1, its preparation method is: 1), according to described weight portion take each component, and add the decocting 2.5 ~ 3.5 hours of 13 ~ 17 times of weight, filter centrifugation removes slag, and is condensed into clear paste;

2), collect medicinal residues, add the decocting 1 hour of 10 times of weight, filter centrifugation removes medicinal residues, is condensed into clear paste;

3), by step 1) and step 2) in gained clear paste mixing, both described medicine.

5. the medicine for the treatment of type 2 diabetes mellitus as claimed in claim 1, is characterized in that: described medicine is the one in tablet, capsule, powder, pill, granule, soft capsule, drop pill, unguentum, oral liquid.