CN105250625A - Pharmaceutical composition for treating female chloasma and application of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating female chloasma and application of pharmaceutical composition Download PDFInfo
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- CN105250625A CN105250625A CN201510821738.9A CN201510821738A CN105250625A CN 105250625 A CN105250625 A CN 105250625A CN 201510821738 A CN201510821738 A CN 201510821738A CN 105250625 A CN105250625 A CN 105250625A
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Abstract
The invention discloses a pharmaceutical composition for treating female chloasma and an application of the pharmaceutical composition. The pharmaceutical composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 21-33 parts of clinacanthus nutans, 30-50 parts of lycium barbarum leaves, 21-33 parts of roasted rhizoma atractylodis macrocephalae, 5-9 parts of allium macrostemon, 5-9 parts of shinyleaf pricklyash roots and 9-15 parts of ardisia chinensis benth. The pharmaceutical composition has an effect of inhibiting tyrosinase activity, is capable of reducing local chromatosis, repairing damaged fibers of the skin, activating skin tissue cells and delaying skin aging, and is suitable for treatment of the female chloasma.
Description
Technical field
The invention belongs to technical field of Chinese medicine, in particular to a kind of pharmaceutical composition and application thereof for the treatment of women's chloasma.
Background technology
Chloasma is a kind of common chromatopathy being mainly in young and middle-aged women face, for color and luster is the patch of yellowish-brown, crineous or dark brown.Modern medicine is thought, chloasma is how relevant with the metabolism of pigment obstacle that endocrine factors, physical factor, chemical factor, struvite factor, trophism factor etc. cause, and belongs to " discosmetic dermatosis " scope.
At present, chloasma mainly contains following several therapeutic modality 1. topical therapeutic.(1) external used medicine is simple, the most the most frequently used Therapeutic Method.External tyrosinase inhibitor ointment, as 5% Hydrochinone Cream, 2-4% kojic acid frost and 3% arbutin etc.Painting has curative effect in various degree after putting on the skin.Such medicine is antioxidant, is easily oxidized in air and daylight, should close, keep in Dark Place.In recent years someone reports use 0.1% tretinoin Ointment in Treatment chloasma, and external glucocorticoid etc. also has certain curative effect.(2) strip off the painting of therapy trichloroacetic acid solution local to put on the skin and can make exfoliation, and remove pigmented spots.Liquid nitrogen cryotherapy is peeled off after can making the freezing necrosis of epidermis, and to remove pigment, grinding operation is, with bistrique, epidermis is ground off one deck, and reaches the object of removing pigment.Postoperatively after wound healing, use sunscreen cream etc., otherwise after Exposure to Sunlight, be easy to recurrence.(3) facial film therapy facial film therapy comprises simple face film agent, face mask cream massotherapy and reverse mould facial film method.Wherein reverse mould facial film method has been widely used in the treatment of chloasma, and obtains promising result.Facial film reverse mould therapy integrates medicine, massage, physical therapy, thus has multiple therapeutical effect.Its treatment procedure is: cation steam profit face-face mask cream massages-shaping reverse mould agent reverse mould.The treatment of ingredient to chloasma of face mask cream plays crucial effect.There is the Chinese herb medicine facial film etc. of the face mask cream of the element that discolors, whitening mask cream and brown patch of specially harnessing the Yellow River at present.(4) laser or intensive pulsed light have report application photorejuvenation and apply Q-switch laser therapy chloasma some patients effective recently.2. whole body therapeutic.Vitamin C: in order to promote hypopigmentation, available vitamin C, best intravenous injection.But all there is the shortcoming that the course for the treatment of is long, curative effect is undesirable in above-mentioned therapy.
Summary of the invention
The object of the invention is to improve on the basis of folk remedy, thus provide a kind of pharmaceutical composition and application for the treatment of women's chloasma, this medicine nourishes kidney yin, calming liver and clearing heat, nourishes blood and seeks, effectively treating chloasma, evident in efficacy, toxic and side effects is low simultaneously, low price.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for women's chloasma, it is prepared from by the traditional Chinese medicinal material raw materials comprising following weight portion: turn round sequence flower 21-33 part, Folium Lycii 30-50 part, Rhizoma Atractylodis Macrocephalae (parched) 21-33 part, Bulbus Allii Macrostemonis 5-9 part, Radix Zanthoxyli 5-9 part, little Herba Ardisiae Japonicae 9-15 part.
Preferably, the pharmaceutical composition for the treatment of women chloasma as above, it is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: turn round sequence flower 26-29 part, Folium Lycii 38-42 part, Rhizoma Atractylodis Macrocephalae (parched) 26-29 part, Bulbus Allii Macrostemonis 6-8 part, Radix Zanthoxyli 6-8 part, little Herba Ardisiae Japonicae 11-13 part.
In a most preferred embodiment of the present invention, the pharmaceutical composition for the treatment of women chloasma as above is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: turn round sequence spend 28 parts, Folium Lycii 40 parts, Rhizoma Atractylodis Macrocephalae (parched) 28 parts, Bulbus Allii Macrostemonis 7 parts, Radix Zanthoxyli 7 parts, little Herba Ardisiae Japonicae 12 parts.
It should be noted that, traditional Chinese medicinal material raw materials of the present invention has following source: turn round sequence flower and select Acanthaceae to turn round the dry herb of sequence flower Clinacanthusnutans (Burm.f.) Lindau; Folium Lycii selects the dry young stem and leaf of matrimony vine of solanaceae plant LyciumchinenseMill.LyciumbarbarumL.; Rhizoma Atractylodis Macrocephalae (parched) selects the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz. to form through parch, method is sprinkled in hot pot by processed with honey wheat bran, add in time smoldering and add Rhizoma Atractylodis Macrocephalae sheet by 10% of processed with honey wheat bran quality, fry to coke yellow, effusion burnt odor gas, take out, sieve removes processed with honey wheat bran; Bulbus Allii Macrostemonis selects the dry bulb of liliaceous plant Chinese onion AlliumchinensisG.Don; Radix Zanthoxyli selects the dry root of rutaceae Radix Zanthoxyli Zanthoxylumnitidum (Roxb.) DC.; Little Herba Ardisiae Japonicae selects the dry Herb of Myrsinacea plant little Herba Ardisiae Japonicae ArdisiachinensisBenth..
In addition, second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of above-mentioned traditional Chinese medicinal material raw materials compositions in the medicine or health product of preparation treatment women chloasma.In pharmaceutical applications, this pharmaceutical composition can be prepared as oral formulations; Oral formulations wherein comprises oral liquid, tablet, capsule, granule.
Compared with prior art, the present invention has the effect of restraint of tyrosinase activity, and the pigmentation of local is reduced, and repairs skin damaged fibers, activating skin histiocyte, delay skin aging, is applicable to treatment women chloasma.In addition, the present invention is that pure Chinese crude drug is prepared from, and has no side effect, low price.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1: the preparation of oral liquid
Take and turn round sequence flower 2.8kg, Folium Lycii 4.0kg, Rhizoma Atractylodis Macrocephalae (parched) 2.8kg, Bulbus Allii Macrostemonis 0.7kg, Radix Zanthoxyli 0.7kg and little Herba Ardisiae Japonicae 1.2kg, merge and pulverize; Again above-mentioned graininess medical material is added water and covers powder 2cm, soak 1-1.2h, pull out medical material put multi-functional extractions filling in decoct with water secondary, add up the water of medical material 10 times amount for the first time, after heated and boiled, slow fire boiling 1.5h, gets decocting liquid, filter, second time adds up the water of medical material 8 times amount, slow fire boiling 1h after heated and boiled, get twice decocting liquid to merge, filter, be concentrated into every milliliter containing 2.5g crude drug amount, put 3-5 DEG C of deepfreeze 24h, cold preservation liquid is filtered, adds appropriate odor mask and antiseptic stirs evenly, obtain medicinal liquid.
Embodiment 2: the preparation of capsule:
Take and turn round sequence flower 3.3kg, Folium Lycii 3.8kg, Rhizoma Atractylodis Macrocephalae (parched) 3.3kg, Bulbus Allii Macrostemonis 0.9kg, Radix Zanthoxyli 0.9kg and little Herba Ardisiae Japonicae 1.3kg, pulverize after merging, again graininess medical material is added water and cover powder 2cm, soak 1-1.2h, then secondary is decocted, add up the water of medical material 10 times amount for the first time, slow fire boiling 1.5h after heated and boiled, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, slow fire boiling 1h after heated and boiled, get twice decocting liquid to merge, filter, filtrate heating is concentrated into thick paste, dry under the condition of 68-70 DEG C, pulverize, cross 100 mesh sieves, obtain Chinese medicine extract, with appropriate microcrystalline Cellulose, dry granulation after carboxymethyl starch sodium mixing, filled capsules shell.
Embodiment 3: Chinese medicine oral liquid is to the effectiveness study of women's chloasma
Women's patient with chloasma 79 example, patient facial region has well-defined larger patch, mostly occurs in Face and cheek, nose, cheekbone portion etc., and color is in deeply brown, the brown or pitchy of ash, and symmetry distribution, NIP shows and squama.The age of all patients within 26-41 year, average out to (32.8 ± 4.5) year; The course of disease within the scope of 1 year-7 years, average (3.6 ± 0.4) year.Adopt random digits table to be divided into test group 41 example and matched group 38 example at random in 1: 1 ratio, two groups of patients compare there was no significant difference in age, the course of disease, diseased region, the state of an illness etc., have comparability.
After on-test, matched group patient oral vitamin C0.2g, vitamin E 0.1g, every day 3 times; Orally taken hemostatic naphthenic acid 0.25g, every day 3 times.Test group patient adopts Chinese medicinal formulae of the present invention to treat, and prescription consists of: turn round sequence flower 28g, Folium Lycii 40g, Rhizoma Atractylodis Macrocephalae (parched) 28g, Bulbus Allii Macrostemonis 7g, Radix Zanthoxyli 7g, little Herba Ardisiae Japonicae 12g; Be decocted in water for oral dose, every day 1 dose, divide and take for 2 times, the moon, premenstrual beginning was taken medicine, monthly 10 days.Two groups was all 1 course for the treatment of with 3 months.After treating a course for the treatment of, " clinical diagnosis of chloasma and the criterion of therapeutical effect " formulated with reference to CAIM (Chinese Association Of Integrative Medicine) Dermatology Professional Committee pigment disease group (Dermatology Professional Committee of CAIM (Chinese Association Of Integrative Medicine) pigment disease group. the clinical diagnosis of chloasma and criterion of therapeutical effect (revised draft in 2003) [J]. Chinese journal of dermatology, 2004, 37 (7): 440.) formulate curative effect determinate standard and evaluate two groups of curative effects, namely according to mottle area, clinical efficacy is divided into basic healing by integration decline index, effective, take a turn for the better, invalid level Four is as follows:
Basic healing: perusal mottle area abatement is greater than more than 90%, and color disappears substantially, and decline after treatment index >=0.8;
Effective: perusal mottle area abatement is greater than 60%, and color is obviously thin out, and decline after treatment index >=0.5;
Take a turn for the better: perusal mottle area abatement is greater than 30%, and color is thin out, and decline after treatment index >=0.3;
Invalid: perusal mottle area abatement is less than 30%, and color change is not obvious, decline index < 0.3 after treatment.
Decline index calculation method: total mark after decline index=(before treating total mark) treatment) the front total mark of/treatment.Effective percentage computational methods: total effective rate=[(basic healing+effective+take a turn for the better)/total number of cases] × 100%.
Can be found out by the clinical efficacy statistical result of table 1, in test group 41 example, basic healing 15 example, effective 14 examples, take a turn for the better 10 examples, and invalid 2 is routine, and total effective rate is 95.1%; In matched group 38 example, basic healing 6 example, effective 9 examples, take a turn for the better 13 examples, and invalid 10 is routine, and total effective rate is 73.7%., obviously, the clinical efficacy of test group is better than matched group.
Table 1 liang group comparitive study (example)
| Group | Case load | Basic healing | Effective | Take a turn for the better | Invalid | Total effective rate (%) |
| Matched group | 38 | 6 | 9 | 13 | 10 | 28(73.7) |
| Test group | 41 | 15 | 14 | 10 | 2 | 39(95.1) |
Claims (6)
1. treat a pharmaceutical composition for women's chloasma, it is characterized in that: described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: turn round sequence flower 21-33 part, Folium Lycii 30-50 part, Rhizoma Atractylodis Macrocephalae (parched) 21-33 part, Bulbus Allii Macrostemonis 5-9 part, Radix Zanthoxyli 5-9 part, little Herba Ardisiae Japonicae 9-15 part.
2. the pharmaceutical composition for the treatment of women chloasma according to claim 1, is characterized in that: described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: turn round sequence flower 26-29 part, Folium Lycii 38-42 part, Rhizoma Atractylodis Macrocephalae (parched) 26-29 part, Bulbus Allii Macrostemonis 6-8 part, Radix Zanthoxyli 6-8 part, little Herba Ardisiae Japonicae 11-13 part.
3. the pharmaceutical composition for the treatment of women chloasma according to claim 2, is characterized in that: described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: turn round sequence spend 28 parts, Folium Lycii 40 parts, Rhizoma Atractylodis Macrocephalae (parched) 28 parts, Bulbus Allii Macrostemonis 7 parts, Radix Zanthoxyli 7 parts, little Herba Ardisiae Japonicae 12 parts.
4. the application of the traditional Chinese medicinal material raw materials compositions described in any one of claim 1-3 in the medicine or health product of preparation treatment women chloasma.
5. application according to claim 4, is characterized in that: described medicine is oral formulations.
6. application according to claim 5, is characterized in that: described oral formulations comprises oral liquid, tablet, capsule, granule.
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| CN201510821738.9A CN105250625A (en) | 2015-11-23 | 2015-11-23 | Pharmaceutical composition for treating female chloasma and application of pharmaceutical composition |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348779A (en) * | 2000-10-17 | 2002-05-15 | 刘宏龙 | Chloasma eliminating medicine |
| CN103638388A (en) * | 2013-12-23 | 2014-03-19 | 中国人民解放军总医院 | Traditional Chinese medicine composition for treating chloasma, preparation and preparation method thereof |
| CN104056103A (en) * | 2014-06-24 | 2014-09-24 | 俞天阳 | Traditional Chinese medicine for treating woman chloasma |
-
2015
- 2015-11-23 CN CN201510821738.9A patent/CN105250625A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1348779A (en) * | 2000-10-17 | 2002-05-15 | 刘宏龙 | Chloasma eliminating medicine |
| CN103638388A (en) * | 2013-12-23 | 2014-03-19 | 中国人民解放军总医院 | Traditional Chinese medicine composition for treating chloasma, preparation and preparation method thereof |
| CN104056103A (en) * | 2014-06-24 | 2014-09-24 | 俞天阳 | Traditional Chinese medicine for treating woman chloasma |
Non-Patent Citations (4)
| Title |
|---|
| 付丹丹: "黄褐斑的中医药治疗概况", 《河南中医》 * |
| 刘爱民: "关于黄褐斑病因病机及辨证分型的探讨", 《中医研究》 * |
| 王用峰: "辨证论治黄褐斑疗效观察", 《陕西中医》 * |
| 谭兴贵: "《中医药膳与食疗》", 30 April 2009, 中国中医药出版社 * |
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