CN105250513A - Skin bactericidal solution and preparation method thereof - Google Patents
Skin bactericidal solution and preparation method thereof Download PDFInfo
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- CN105250513A CN105250513A CN201510801403.0A CN201510801403A CN105250513A CN 105250513 A CN105250513 A CN 105250513A CN 201510801403 A CN201510801403 A CN 201510801403A CN 105250513 A CN105250513 A CN 105250513A
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Abstract
The invention discloses a skin bactericidal solution, belonging to the field of medical daub preparations. The skin bactericidal solution comprises the following components: 0.1-10 parts of chitosan or derivatives thereof, 0.01-3 parts of chlorhexidine or derivatives thereof, 0.01-10 parts of plant extraction essence and 5-30 parts of water, wherein the plant extraction essence refers to essence leaching solution of salvia prionitis, negundo chastetree fruit, seed of amaranthus caudatus and lagenaria siceraria. The components are matched with one another, and the skin bactericidal solution has a broad-spectrum antibacterial effect, has bacteriostatic and antibacterial effects on dermatophytes and saccharomycetes such as candida and malassezia and also has a certain inhibiting effect on some Gram-positive bacilli and coccus. The skin bactericidal solution is used for skin infections caused by fungi, bacteria and moulds, such as tinea of feet and hands, tinea corporis and cruris, tinea versicolor, neurodermatitis, rash, eczema, mosquito bite and various skin itches.
Description
Technical field
The present invention relates to and medically smear formulation art, particularly a kind of skin antibacterial liquid and preparation method thereof.
Background technology
Skin, due to hyperhidrosis, humidity, causes a more damp and hotter environment, for many microbial growths and breeding provide good condition, so the sickness rate of skin infection is higher, common are fungal infection and bacteriological infection two class.
Pathogen major part is invaded by skin, the various wart classes that such as virus causes, fungus-caused dermatophytosis.Sick coccigenic suppurative dermatosis.The microbial leprosy tuberculosis of bar.The schistosome cercarial dermatitis that animal schistosomes cercaria causes.The scabies etc. that acaricide causes.Having in addition by respiratory infectious: rubella, measles, coccidioidomycosis, successively histoplasmosis etc., the person of spreading through sex intercourse: as syphilis, gonorrhea, inguinal lymph, granuloma etc., some pathogen are brought into by vector, as cutaneous leishmaniasis filaricide etc., some organism also can injure skin, causes dermatosis, as caterpillar dermatitis, mite dermatitis, scorpion sting, venom etc.
Develop a kind of antibacterial comprehensively and the skin antibacterial liquid of good antimicrobial effect is significant.
Summary of the invention
In order to make up above deficiency, the invention provides and a kind ofly there is spectrum antibacterial effect and skin antibacterial liquid of good antimicrobial effect and preparation method thereof.
Technical scheme of the present invention is:
A kind of skin antibacterial liquid, according to weight parts, comprising: chitosan or derivatives thereof 0.1-10 part, chlorhexidine or derivatives thereof 0.01-3 part, plant extract elite 0.01-10 part, water 5-30 part.
Preferably, the elite lixiviating solution of described plant extract fine Huawei Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
Further, the preparation method of described elite lixiviating solution is as follows:
1) Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling are pulverized, wherein, the mass ratio of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling is 3-5:1-2:1:1;
2) ethanol is added, lixiviate 50-100min;
3) the solid slag of filtering, steams except the ethanol in filtrate, obtains the elite lixiviating solution of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
Preferably, according to weight parts, comprising: chitosan or derivatives thereof 3-8 part, chlorhexidine or derivatives thereof 0.08-2 part, plant extract elite 3-8 part, water 8-12 part.
The preparation method of described skin antibacterial liquid, comprises step:
1) get chitosan or derivatives thereof, chlorhexidine or derivatives thereof, plant extract elite, water, and be heated to 60-80 DEG C;
2) stir, homogenizing;
3) cool, packaging.
Arisaema balansae Engl. grass, containing quinone, has obvious antagonism to gram positive bacteria, hay village bacterium, staphylococcus aureus; Fructus Viticis Cannabifoliae is inhibited to staphylococcus aureus, escherichia coli, bacillus pyocyaneus; An inveterate smoker millet has the effect of Developing restraint to various pathomycete, has antibacterial action to gram-positive bacteria, and nontoxic to human cell; Pericarpium Lagenariae sicerariae seedling has the effect of detoxicating and resolving stagnation of pathogens.
Chlorhexidine is cationic surfactant, has broad-spectrum sterilization, bacteriostasis, and antimicrobial spectrum comprises Grain-positive and negative bacterium, fungus and some virus.Chitosan-phospholipid complex can Antibacterial activity, and chitosan again can wound healing.
Beneficial effect of the present invention is:
In the present invention, each component cooperatively interacts, and has broad-spectrum antibacterial action, has antibacterial, antibacterial action, also have certain inhibitory action to some Gram-positive bacillus and coccus to dermatophytosis, yeast (as candidiasis, chlosma) etc.For fungus, antibacterial, mould microbial skin infection etc., as: hands, tinea pedis; Body, tinea cruris; Tinea versicolor; Neurodermatitis; Erythra; Eczema; Mosquito bite and various skin pruritus.
Detailed description of the invention
Embodiment 1
A kind of skin antibacterial liquid, comprising: chitosan 3 parts, chlorhexidine 1 part, plant extract elite 8 parts, 10 parts, water.
Wherein, the elite lixiviating solution of plant extract fine Huawei Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described elite lixiviating solution is as follows:
1) Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling are pulverized, wherein, the mass ratio of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling is 4:2:1:1;
2) ethanol is added, lixiviate 100min;
3) the solid slag of filtering, steams except the ethanol in filtrate, obtains the elite lixiviating solution of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described skin antibacterial liquid, comprises step:
1) get chitosan, chlorhexidine, plant extract elite, water, and be heated to 70 DEG C;
2) stir, homogenizing;
3) cool, packaging.
Embodiment 2
A kind of skin antibacterial liquid, comprising: chitosan 8 parts, chlorhexidine 0.5 part, plant extract elite 5 parts, 20 parts, water.
Wherein, the elite lixiviating solution of plant extract fine Huawei Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described elite lixiviating solution is as follows:
1) Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling are pulverized, wherein, the mass ratio of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling is 5:1:1:1;
2) ethanol is added, lixiviate 80min;
3) the solid slag of filtering, steams except the ethanol in filtrate, obtains the elite lixiviating solution of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described skin antibacterial liquid, comprises step:
1) get chitosan, chlorhexidine, plant extract elite, water, and be heated to 80 DEG C;
2) stir, homogenizing;
3) cool, packaging.
Embodiment 3
A kind of skin antibacterial liquid, comprising: chitosan 2 parts, chlorhexidine 0.05 part, plant extract elite 10 parts, 15 parts, water.
Wherein, the elite lixiviating solution of plant extract fine Huawei Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described elite lixiviating solution is as follows:
1) Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling are pulverized, wherein, the mass ratio of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling is 3:2:1:1;
2) ethanol is added, lixiviate 60min;
3) the solid slag of filtering, steams except the ethanol in filtrate, obtains the elite lixiviating solution of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described skin antibacterial liquid, comprises step:
1) get chitosan, chlorhexidine, plant extract elite, water, and be heated to 60 DEG C;
2) stir, homogenizing;
3) cool, packaging.
Embodiment 4
A kind of skin antibacterial liquid, comprising: chitosan 3 parts, chlorhexidine 0.2 part, plant extract elite 7 parts, 8 parts, water.
Wherein, the elite lixiviating solution of plant extract fine Huawei Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described elite lixiviating solution is as follows:
1) Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling are pulverized, wherein, the mass ratio of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling is 3:1:1:1;
2) ethanol is added, lixiviate 70min;
3) the solid slag of filtering, steams except the ethanol in filtrate, obtains the elite lixiviating solution of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
The preparation method of described skin antibacterial liquid, comprises step:
1) get chitosan, chlorhexidine, plant extract elite, water, and be heated to 70 DEG C;
2) stir, homogenizing;
3) cool, packaging.
Claims (5)
1. a skin antibacterial liquid, is characterized in that, according to weight parts, comprising: chitosan or derivatives thereof 0.1-10 part, chlorhexidine or derivatives thereof 0.01-3 part, plant extract elite 0.01-10 part, water 5-30 part.
2. skin antibacterial liquid as claimed in claim 1, is characterized in that: the elite lixiviating solution of described plant extract fine Huawei Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
3. skin antibacterial liquid as claimed in claim 2, it is characterized in that, the preparation method of described elite lixiviating solution is as follows:
1) Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling are pulverized, wherein, the mass ratio of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet, Pericarpium Lagenariae sicerariae seedling is 3-5:1-2:1:1;
2) ethanol is added, lixiviate 50-100min;
3) the solid slag of filtering, steams except the ethanol in filtrate, obtains the elite lixiviating solution of Arisaema balansae Engl. grass, Fructus Viticis Cannabifoliae, an inveterate smoker millet and Pericarpium Lagenariae sicerariae seedling.
4. skin antibacterial liquid as claimed in claim 1, is characterized in that, according to weight parts, comprising: chitosan or derivatives thereof 3-8 part, chlorhexidine or derivatives thereof 0.08-2 part, plant extract elite 3-8 part, water 8-12 part.
5. the preparation method of skin antibacterial liquid as claimed in claim 1, is characterized in that, comprise step:
1) get chitosan or derivatives thereof, chlorhexidine or derivatives thereof, plant extract elite, water, and be heated to 60-80 DEG C;
2) stir, homogenizing;
3) cool, packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510801403.0A CN105250513A (en) | 2015-11-19 | 2015-11-19 | Skin bactericidal solution and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510801403.0A CN105250513A (en) | 2015-11-19 | 2015-11-19 | Skin bactericidal solution and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105250513A true CN105250513A (en) | 2016-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510801403.0A Pending CN105250513A (en) | 2015-11-19 | 2015-11-19 | Skin bactericidal solution and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022079142A1 (en) * | 2020-10-14 | 2022-04-21 | Medoderm Gmbh | Liquid composition for use in the prevention or reduction of skin irritation, allergy and/or an infectious disease |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223058A (en) * | 2013-05-08 | 2013-07-31 | 南通大学 | Fructus Viticis Negundo total flavone extract, and preparation method and medicinal uses thereof |
| CN103356738A (en) * | 2013-07-20 | 2013-10-23 | 日照众生海洋生物科技有限公司 | Skin disinfection gel and its application |
-
2015
- 2015-11-19 CN CN201510801403.0A patent/CN105250513A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103223058A (en) * | 2013-05-08 | 2013-07-31 | 南通大学 | Fructus Viticis Negundo total flavone extract, and preparation method and medicinal uses thereof |
| CN103356738A (en) * | 2013-07-20 | 2013-10-23 | 日照众生海洋生物科技有限公司 | Skin disinfection gel and its application |
Non-Patent Citations (2)
| Title |
|---|
| 惠永正: "《中药天然产物大全 10 下 中药》", 31 January 2011, 上海科学技术出版社 * |
| 王本祥: "《现代中药药理与临床》", 30 June 2004, 天津科技翻译出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022079142A1 (en) * | 2020-10-14 | 2022-04-21 | Medoderm Gmbh | Liquid composition for use in the prevention or reduction of skin irritation, allergy and/or an infectious disease |
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Application publication date: 20160120 |