CN105250424A - Drug for preventing and treating pullorum disease and preparation method thereof - Google Patents
Drug for preventing and treating pullorum disease and preparation method thereof Download PDFInfo
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- CN105250424A CN105250424A CN201510775478.6A CN201510775478A CN105250424A CN 105250424 A CN105250424 A CN 105250424A CN 201510775478 A CN201510775478 A CN 201510775478A CN 105250424 A CN105250424 A CN 105250424A
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Abstract
The invention discloses a drug for preventing and treating a pullorum disease. The drug is prepared from, by mass, 110-145 parts of radix paeoniae alba, 195-225 parts of bighead atractylodes rhizomes, 125-155 parts of Chinese pulsatilla roots, 130-165 parts of radix scutellariae, 170-200 parts of rhizoma atractylodis, 340-375 parts of medicated leaven, 230-260 parts of hawthorns, 310-340 parts of herba pteridis multifidae and 140-175 parts of flos chrysanthemi indicis. According to the drug for preventing and treating the pullorum disease, no incompatibility exists in compatibility of all the raw materials, the occurrence rate of the pullorum disease can be significantly decreased, and the good preventing and treating effects on the pullorum disease are achieved; in addition, no toxic or side effect exists, use is safe, and no harmful drug residue exists.
Description
Technical field
The present invention relates to medicine of a kind of chicken disease control and preparation method thereof, particularly a kind of have medicine of obvious preventive and therapeutic action and preparation method thereof to Pullorum Disease.
Background technology
Pullorum Disease is that by the infectious disease of S. pullonum cloudy gas, primary disease is a kind of extremely common infectious disease, and its Excreta is important communication media, simultaneously also by egg vertical transmission.The cardinal symptom and the pathological changes that infect this disease are: chickling performance does not eat feedstuff, and be afraid of cold, health is rolled up, and wing is sagging, and the depressed or lethargy of spirit, row's thick white or yellowish, light green loose stool, anus is closed by the excrement block hardened sometimes, dyspnea.Minority infects serious adult sick chicken performance lethargy, and row's yellow green or Ovum Gallus domesticus album sample loose stool, the visible liver of major lesions, spleen enlargement, fragility, have downright bad point, and the dark red hyperemia of kidney or pale anemia often occur that peritonitis changes.The visible ovarian atrophy of laying hen, ovum degeneration, sick chicken is laid eggs stopping.
Widely using due to chemosynthesis veterinary drug in livestock-raising process, the residue of veterinary drug problem in animal product is more and more outstanding.Domestic and international result of study shows, the long-term or abuse veterinary drug that exceeds standard not only can reduce livestock products quality, causes heavy economic losses, and can be detrimental to health, serious threat to life, larger than the harm of animal epidemic to the mankind.
Western medicine focuses on Eradicates except pathogenic factor, eliminates the cause of disease; Entirety emphasized by Chinese medicine, focuses on the resistance against diseases improving body, the various functions of adjustment, balance body, and application safety is reliable, adopts Chinese medicine to replace western medicine disease, can overcome the many disadvantages that Western medicine exists.Therefore research and develop and a kind ofly treat the drug residue free of Pullorum Disease, the generation that has no drug resistance, clinical effectiveness significant specially good effect Chinese herb medicine are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome the above-mentioned deficiency of prior art and a kind of medicine preventing and treating Pullorum Disease is provided, in medicine of the present invention there is not incompatibility in each material combination, obviously can reduce the incidence rate of Pullorum Disease, good preventive and therapeutic action is had to Pullorum Disease, and have no side effect, use safety, remains without hazardous drugs.
Another object of the present invention is to provide a kind of preparation method of said medicine, and its technique is simple, and its crude drug is common, cheap.
Technical scheme of the present invention is: a kind of medicine preventing and treating Pullorum Disease, and it is made up of the crude drug of following masses part proportioning: Radix Paeoniae Alba 110-145 part, Rhizoma Atractylodis Macrocephalae 195-225 part, Radix Pulsatillae 125-155 part, Radix Scutellariae 130-165 part, Rhizoma Atractylodis 170-200 part, Massa Medicata Fermentata 340-375 part, Fructus Crataegi 230-260 part, Herba Pteridis Multifidae 310-340 part, Flos Chrysanthemi Indici 140-175 part.
Its further preferred mass part proportioning is: Radix Paeoniae Alba 110-140 part, Rhizoma Atractylodis Macrocephalae 195-220 part, Radix Pulsatillae 130-155 part, Radix Scutellariae 140-165 part, Rhizoma Atractylodis 170-195 part, Massa Medicata Fermentata 350-375 part, Fructus Crataegi 230-255 part, Herba Pteridis Multifidae 310-335 part, Flos Chrysanthemi Indici 150-175 part.
Its further preferred mass part proportioning is: Radix Paeoniae Alba 110-135 part, Rhizoma Atractylodis Macrocephalae 200-220 part, Radix Pulsatillae 140-155 part, Radix Scutellariae 150-165 part, Rhizoma Atractylodis 180-195 part, Massa Medicata Fermentata 350-370 part, Fructus Crataegi 230-250 part, Herba Pteridis Multifidae 310-330 part, Flos Chrysanthemi Indici 160-175 part.
Its further preferred mass part proportioning is: Radix Paeoniae Alba 120-135 part, Rhizoma Atractylodis Macrocephalae 200-215 part, Radix Pulsatillae 140-150 part, Radix Scutellariae 150-160 part, Rhizoma Atractylodis 180-190 part, Massa Medicata Fermentata 350-365 part, Fructus Crataegi 240-250 part, Herba Pteridis Multifidae 320-330 part, Flos Chrysanthemi Indici 160-170 part.
Its further preferred mass part proportioning is: Radix Paeoniae Alba 120-130 part, Rhizoma Atractylodis Macrocephalae 200-210 part, Radix Pulsatillae 145-150 part, Radix Scutellariae 155-160 part, Rhizoma Atractylodis 185-190 part, Massa Medicata Fermentata 350-360 part, Fructus Crataegi 246-250 part, Herba Pteridis Multifidae 325-330 part, Flos Chrysanthemi Indici 160-165 part.
Its further preferred mass part proportioning is: the Radix Paeoniae Alba 130 parts, the Rhizoma Atractylodis Macrocephalae 210 parts, the Radix Pulsatillae 145 parts, Radix Scutellariae 155 parts, Rhizoma Atractylodis 185 parts, Massa Medicata Fermentata 360 parts, Fructus Crataegi 246 parts, Herba Pteridis Multifidae 325 parts, Flos Chrysanthemi Indici 165 parts.
Another technical scheme of the present invention is: a kind of preparation method of preventing and treating the medicine of Pullorum Disease, it mainly comprises the steps:
One, by formula weighting raw materials;
Two, pulverized by the crude drug claimed, mix homogeneously, obtains the medicine preventing and treating Pullorum Disease.
The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 100-300 mesh sieve.
The present invention further another technical scheme is: after step 2 raw material pulverizing, crosses 150-300 mesh sieve.
The primary symbols that the present invention uses and name resolving as follows:
-: numerical range, such as 1-5 represents 1 to 5.
The primary raw material medicine that the present invention uses is described as follows:
The Radix Paeoniae Alba: also claim Paeonia sterniana Fletcher in Journ. is Ranunculaceae Paeonia plant.Have long cultivation history in China, have won fame both at home and abroad, it claims Paeonia sterniana Fletcher in Journ..Its root can be used as medicine.Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
The Rhizoma Atractylodis Macrocephalae: another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc., belong to Compositae, [WTBX herbaceos perennial.The nice and cool weather of happiness, is used as medicine with rhizome, has multinomial medicinal function.Mainly be distributed in the mountain area wetlands such as Sichuan, Yunnan, Guizhou.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, and for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " is recorded: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO, go in taste wet, except gastric heat, strong taste, enter diet, antiabortive.”
The Radix Pulsatillae: Ranunculaceae, Anemone herbaceos perennial, long have root stock, and blade is avette, calyx bluish violet.Another name has how grass, powder silkweed, Bai Toucao, old aunt grass etc.The bleedings such as treatment hemorrhoid.Control toxic-heat and blood stasis, pyrexial malaria cold and heat, epistaxis, internal hemorrhoid with bleeding.
Radix Scutellariae: call light Siberian cocklebur, Scutellaria lateriflora, sub-Siberian cocklebur, withered Siberian cocklebur, stalwart Siberian cocklebur, Flos Camelliae Japonicae root), a kind of medical material, eliminates nervous and uneasy, and health is stablized.
Rhizoma Atractylodis: perennial herb.Stem list is raw or cluster, and stem branch is dredged by arachnoid hair.Rhizoma Atractylodis root stock is used as medicine, and has dampness, changes effect that is turbid, pain relieving.
Massa Medicata Fermentata: for Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum mud, Semen Phaseoli, fresh Fructus Xanthii add the herbal leaven of flour or wheat bran after fermentation.For retention of food and drink, dyspepsia, distension and fullness in the abdomen, inappetence, vomiting dysentery.
Fructus Crataegi: have another name called fruit, Fructus Pyri Pashiae in mountain, Rosaceae Crataegus, deciduous tree.Stone fruit, caryoplasm is hard, and sarcocarp is thin, and taste is micro-sour and astringent.Fruit is raw-eaten or make preserved fruit fruitcake, can be used as medicine after drying, Chinese distinctive medicine fruit dual-purpose seeds, there is the effects such as blood fat reducing, blood pressure, heart tonifying, arrhythmia, also be simultaneously the good medicine of spleen benefiting and stimulating the appetite, relieving dyspepsia, phlegm reduction of blood circulation promoting, the disease such as, hernia, blood stasis full to chest and diaphragm spleen, amenorrhea has good curative effect.Flavone compound vitexin in Fructus Crataegi is the medicine that a kind of antitumaous effect is stronger, and its extract all has certain effect to growth of cancer cells, propagation and infiltration metastasis in suppression body.
Herba Pteridis Multifidae: Herba Pteridis Multifidae mainly and ecological environment leaf with it is named, and another name is a lot, as Rhizoma Seu Herba Pteridis Dactylinae, halymenia dentata, Pteris multifida etc., is a kind of pteridophyta, belongs to Pteridaceae, Pteris.With all herbal medicine, cool in nature, mildly bitter flavor, returns liver, kidney, large intestine channel, has the effects such as clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, subduing swelling and detoxicating, is used for the treatment of dysentery, enteritis, icterohepatitis, spits blood, has blood in stool, the disease such as hematuria.
Flos Chrysanthemi Indici: be Compositae herbaceos perennial, the capitate profile of Flos Chrysanthemi Indici is similar to Flos Chrysanthemi, spherical in class, diameter 0.3 ~ 1cm, brown color.Flos Chrysanthemi Indici cold nature, tool dispelling wind and heat pathogens, subduing swelling and detoxicating.Furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis can be treated, the disease such as dizzy of having a headache.
In medicine of the present invention there is not incompatibility in each material combination, obviously can reduce the incidence rate of Pullorum Disease, have good preventive and therapeutic action, and have no side effect, use safety to Pullorum Disease, remains without hazardous drugs.
Drug use method of the present invention: during nursing, every 500 kg diet, take the medicine that 1800-2000 gram is prevented and treated Pullorum Disease, again by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, within 10 days, is a course for the treatment of, can feed a course for the treatment of of this medicine every 20 days.
In order to be illustrated more clearly in the present invention, enumerate following examples, but it is without any restrictions to scope of invention.
Detailed description of the invention
embodiment 1
Take Radix Paeoniae Alba 130g, Rhizoma Atractylodis Macrocephalae 210g, Radix Pulsatillae 145g, Radix Scutellariae 155g, Rhizoma Atractylodis 185g, Massa Medicata Fermentata 360g, Fructus Crataegi 246g, Herba Pteridis Multifidae 325g, Flos Chrysanthemi Indici 165g, these material compositions are the quality after drying, 150-300 order is ground into super micron mill, mix homogeneously, then packs with plastic bag sealing, the obtained medicine preventing and treating Pullorum Disease.
using method:during each nursing, every 500 kilograms of feedstuffs mixed up, take the medicine that 1925 grams of the present embodiment prevent and treat chick typhoid fever, again by this medicine with appropriate water to mixing up, then add in feedstuff, mix all, feed immediately, every day is sooner or later each feeds once, within 10 days, is a course for the treatment of, can feed a course for the treatment of of this medicine every 20 days.
embodiment 2-14, comparative example 1-2
Embodiment 2-12 is except raw material mass mixture ratio is different from embodiment 1, its raw material type and step of preparation process and using method identical with embodiment 1, comparative example 1 eliminates Radix Scutellariae on the basis of embodiment 1, comparative example 2 eliminates Flos Chrysanthemi Indici on the basis of embodiment 1, the raw material that embodiment 1-12, comparative example 1-2 use and quality as shown in Table 1 below, table 1 below illustrates embodiment 1-12, raw material that comparative example 1-2 uses and quality.
Table 1
Clinical practice one:
Hengyang chicken house, spring, a group laying hen spirit was depressed, and feed intake drops to original 1/3rd, and diarrhoea, has a small amount of white urate just, was judged to be Pullorum Disease by clinical and laboratory diagnosis.Select 600 sick chickens, sick chicken is divided into 15 groups at random, often organize 40, respectively with embodiment 1-12, comparative example 1-2 institute's pharmacy and: ciprofloxacin treatment (matched group) is treated, medication is after 10 days, use the chicken group more than 90% of the made Drug therapy of the present invention to get well, the chicken group 80% of ciprofloxacin treatment group treatment gets well, and result is as table 2:
Table 2
As can be seen from Table 2, medicine of the present invention has significant therapeutic effect to Pullorum Disease, and cure rate is higher than ciprofloxacin treatment group.
Clinical practice two:
In order to prove the feeding effect of the present invention to chicken, the chicken house occurred in epidemic situation repeatedly tries feeding experiment, and choose 600, large-scale chicken farm chick, body weight size, health status are basically identical, are divided into 15 groups at random, often organizes 40.Wherein 14 groups is experimental group, the feedstuff that described in embodiment 1-12, comparative example 1-2, medicine is made into of feeding respectively, twice daily, continuous 10 days, feeds a course for the treatment of every 20 days.Another group is for matched group, and feeding does not add the identical feedstuff of medicine, and the nursing number of times of 15 groups of chicks, feeding volume, nursing time are all identical.Contrast the various performance indications of 15 groups of chicks, meansigma methods is as table 3.
After 40 days, 15 groups of chick situations are as table 3:
Table 3
Can it is evident that from table, experimental group chick is after continuous feeding feedstuff provided by the invention, and the comparatively matched group that increases weight increases obviously, and experimental group chick comparatively matched group honey stomach, energetic, state is good, occurs without Pullorum Disease disease.
So the present invention is not limited to the protective agents as Pullorum Disease, as long as the composition of raw materials medicine identical or equivalent with the present invention just drops within protection scope of the present invention.Also drop on making any one Chinese medicine preparation with the raw material preventing and treating the protective agents same recipe of Pullorum Disease of the present invention within protection scope of the present invention, as long as the medicine that namely composition of raw materials is identical with the present invention just drops within protection scope of the present invention.
Claims (9)
1. prevent and treat a medicine for Pullorum Disease, it is characterized in that it is made up of the crude drug of following masses part proportioning: Radix Paeoniae Alba 110-145 part, Rhizoma Atractylodis Macrocephalae 195-225 part, Radix Pulsatillae 125-155 part, Radix Scutellariae 130-165 part, Rhizoma Atractylodis 170-200 part, Massa Medicata Fermentata 340-375 part, Fructus Crataegi 230-260 part, Herba Pteridis Multifidae 310-340 part, Flos Chrysanthemi Indici 140-175 part.
2. the medicine preventing and treating Pullorum Disease according to claim 1, is characterized in that Radix Paeoniae Alba 110-140 part, Rhizoma Atractylodis Macrocephalae 195-220 part, Radix Pulsatillae 130-155 part, Radix Scutellariae 140-165 part, Rhizoma Atractylodis 170-195 part, Massa Medicata Fermentata 350-375 part, Fructus Crataegi 230-255 part, Herba Pteridis Multifidae 310-335 part, Flos Chrysanthemi Indici 150-175 part.
3. the medicine preventing and treating Pullorum Disease according to claim 1, is characterized in that Radix Paeoniae Alba 110-135 part, Rhizoma Atractylodis Macrocephalae 200-220 part, Radix Pulsatillae 140-155 part, Radix Scutellariae 150-165 part, Rhizoma Atractylodis 180-195 part, Massa Medicata Fermentata 350-370 part, Fructus Crataegi 230-250 part, Herba Pteridis Multifidae 310-330 part, Flos Chrysanthemi Indici 160-175 part.
4. the medicine preventing and treating Pullorum Disease according to claim 1, is characterized in that Radix Paeoniae Alba 120-135 part, Rhizoma Atractylodis Macrocephalae 200-215 part, Radix Pulsatillae 140-150 part, Radix Scutellariae 150-160 part, Rhizoma Atractylodis 180-190 part, Massa Medicata Fermentata 350-365 part, Fructus Crataegi 240-250 part, Herba Pteridis Multifidae 320-330 part, Flos Chrysanthemi Indici 160-170 part.
5. the medicine preventing and treating Pullorum Disease according to claim 1, is characterized in that Radix Paeoniae Alba 120-130 part, Rhizoma Atractylodis Macrocephalae 200-210 part, Radix Pulsatillae 145-150 part, Radix Scutellariae 155-160 part, Rhizoma Atractylodis 185-190 part, Massa Medicata Fermentata 350-360 part, Fructus Crataegi 246-250 part, Herba Pteridis Multifidae 325-330 part, Flos Chrysanthemi Indici 160-165 part.
6. the medicine preventing and treating Pullorum Disease according to claim 1, is characterized in that the Radix Paeoniae Alba 130 parts, the Rhizoma Atractylodis Macrocephalae 210 parts, the Radix Pulsatillae 145 parts, Radix Scutellariae 155 parts, Rhizoma Atractylodis 185 parts, Massa Medicata Fermentata 360 parts, Fructus Crataegi 246 parts, Herba Pteridis Multifidae 325 parts, Flos Chrysanthemi Indici 165 parts.
7. prevent and treat the preparation method of the medicine of Pullorum Disease according to claim 1, it is characterized in that: it mainly comprises the steps:
One, weighting raw materials;
Two, pulverized by the crude drug claimed, mix homogeneously, obtains the medicine preventing and treating Pullorum Disease.
8. prevent and treat the preparation method of the medicine of Pullorum Disease according to claim 7, it is characterized in that: after step 2 raw material pulverizing, cross 100-300 mesh sieve.
9. preparation method of preventing and treating the medicine of Pullorum Disease according to claim 7, is characterized in that: after step 2 raw material pulverizing, crosses 150-300 mesh sieve.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726735A (en) * | 2016-04-18 | 2016-07-06 | 巫璐君 | Medicine for preventing and treating chicken pullorum |
| CN106421063A (en) * | 2016-08-29 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicine composition for treating and treating pullorum disease |
| CN106421037A (en) * | 2016-09-28 | 2017-02-22 | 西南大学 | Traditional Chinese medicine composition for preventing and treating pullorum salmonellosis |
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| CN104644833A (en) * | 2013-11-20 | 2015-05-27 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating pullorum disease and preparation method of same |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105726735A (en) * | 2016-04-18 | 2016-07-06 | 巫璐君 | Medicine for preventing and treating chicken pullorum |
| CN106421063A (en) * | 2016-08-29 | 2017-02-22 | 旌德县德源农业开发有限公司 | Traditional Chinese medicine composition for treating and treating pullorum disease |
| CN106421037A (en) * | 2016-09-28 | 2017-02-22 | 西南大学 | Traditional Chinese medicine composition for preventing and treating pullorum salmonellosis |
| CN106421037B (en) * | 2016-09-28 | 2019-08-16 | 西南大学 | Traditional Chinese medicine composition for preventing and treating pullorum salmonellosis |
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