CN105235253A - Biological chip eluting device - Google Patents
Biological chip eluting device Download PDFInfo
- Publication number
- CN105235253A CN105235253A CN201510711015.3A CN201510711015A CN105235253A CN 105235253 A CN105235253 A CN 105235253A CN 201510711015 A CN201510711015 A CN 201510711015A CN 105235253 A CN105235253 A CN 105235253A
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- biochip
- sidewall
- diapire
- installing hole
- piston piece
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Abstract
The invention relates to a biological chip eluting device. Biomass chips are flowing-through type chips. The biological chip eluting device comprises a containing piece and a piston piece. The containing piece comprises a bottom wall and a side wall surrounding the bottom wall. Installing holes for arranging the biological chips are formed in the bottom wall of the containing piece in a penetrating manner. The piston piece can stretch into the containing piece and is in movable sealing contact with the side wall, and a pressing cavity is formed among the piston piece, the bottom wall and the side wall. The piston piece can move towards the bottom wall so that the pressure in the pressing cavity can be increased, and fluid in the flowing-through type chips can flow out. By means of the biological chip eluting device, liquid on the biological chips can be effectively removed.
Description
Technical field
The present invention relates to biochip field, particularly relate to a kind of biochip washing device.
Background technology
Biochip refers to by microelectronics, micro-processing technology, the miniature biochemical system that solid substrate builds, to realize accurately, fast, in large quantities detecting cell, DNA, RNA, protein, polypeptide or other biological components.
In the testing process of biochip, substantially all can there is solution reaction step.And after solution reaction step terminates, all need to carry out wash-out to biochip, so that the detection liquid on biochip or other liquid be attached on biochip are got rid of.Along with the fast development of biotechnology, also more and more higher to the requirement of the washing device of biochip.
In the prior art, usually detection liquid or other liquid be attached on biochip effectively cannot be got rid of, easily on chip, produce liquid residue.In ensuing detection, this residual liquid will produce larger impact to testing result.
Therefore, a kind of device effectively removing the liquid on biochip is needed.
Summary of the invention
For the problems referred to above, the present invention proposes a kind of biochip washing device, use this biochip washing device effectively can remove liquid on biochip.
According to the present invention proposes a kind of biochip washing device, biochip is for flowing through formula chip, it is characterized in that, biochip washing device comprises: receiving member, receiving member comprises diapire and surrounds the sidewall of diapire, on the diapire of receiving member, penetration type is configured with the installing hole for arranging biochip, and the piston piece that can extend in receiving member, piston piece contacts with sidewall movable sealed, at piston piece, between diapire and sidewall, form pressure chamber, wherein, piston piece can towards diapire motion to increase the pressure in pressure chamber.
By biochip washing device of the present invention, biochip can be set in installing hole.Now, indent is substantially closed or completely closed.When piston piece moves towards diapire, the pressure increase in pressure chamber.In normal state, the bottom flowing through formula chip is closed, with effective carrying liquid.And when pressing the pressure increase in chamber in certain limit, flowing through formula chip bottom opens, thus liquid can be made to leave chip, effectively can take out the liquid on biochip thus, to realize the wash-out to biochip.Easily liquid can be extruded by this structure, not easily produce the residual of liquid, ensure that the accuracy of subsequent detection thus.
In one embodiment, installing hole is multiple, and each described installing hole can be selectively opened or closed.Multiple biochip can be installed by arranging multiple installing hole simultaneously, and wash-out can be carried out to multiple biochip thus simultaneously.In addition, when not needing to use wherein one or more installing holes, installing hole can be closed to ensure to press the pressure energy in chamber to increase smoothly.
In one embodiment, being configured with force side pressing dorsad on the one end in chamber of piston piece, by pressing down piston piece to force side applying pressure energy, piston piece being moved towards diapire.Can conveniently piston piece be effectively made to move by exerting pressure to force side.
In one embodiment, piston piece presses chamber to extend to make force side reach outside sidewall dorsad, and the size perpendicular to the direction of motion of force side is greater than the size of opening perpendicular to the direction of motion of sidewall formation.This structure facilitates user and manipulates force side.
In one embodiment, diapire and the detachable connection of sidewall.Thus biochip can be taken out easily.
In one embodiment, biochip washing device also comprises the housing surrounding receiving member, housing comprises the drain pan wall of the side of the piston piece being dorsad arranged at diapire, and be connected with drain pan wall and surround the side shell wall of sidewall, drain pan wall in the region corresponding with installing hole for closing.By arranging this housing, biochip washing device can be placed in water-bath or in drying box and carry out incubation.
In one embodiment, be configured with the groove of opening towards installing hole in the region corresponding with installing hole of drain pan wall, the biochip be inserted in installing hole can contact with the surface of groove.More evenly and rapidly incubation can be carried out to biochip by this structure.
In one embodiment, diapire has pin towards drain pan wall is extended, in not corresponding with the installing hole region of drain pan wall, be configured with the jack corresponding with pin, pin can be inserted in jack.By pin is inserted in jack, receiving member stably can be remained in housing.
In one embodiment, on drain pan wall, receiving member is extended with foot dorsad, and jack extends in foot.Stably kerve and receiving member stably can be combined further by this structure, and biochip washing device can be more stably arranged in platform or plane.
In one embodiment, sidewall comprises the first side wall be fixedly linked with diapire, and the second sidewall be connected with the first side wall detachable-type sealed.Can when biochip be placed in installing hole by this structure, the first side wall and the second sidewall are separated, and the sidewall of piston piece and receiving member need not be made to separate, the regular fractionation between piston piece with receiving member can be avoided thus and be connected, thus effectively ensure that the sealed stability contacted between piston piece with the second sidewall, and then effectively can increase the pressure in pressure chamber when piston piece moves towards receiving member.
In one embodiment, the first seal is configured with in the edge towards the second sidewall of the first side wall, be configured with the second seal in the edge towards the first side wall of the second sidewall, the first seal and the second seal contact with by the first side wall with the second sidewall is sealed links together.
Compared with prior art, the invention has the advantages that: biochip can be set in installing hole by (1).(2) when piston piece towards receiving member diapire motion time, pressure chamber in pressure increase, the liquid in biochip can effectively be extruded.Easily liquid can be extruded by this structure, not easily produce the residual of liquid, ensure that the accuracy of subsequent detection thus.(3) this biochip washing device is easy to operate, and flexibility is high, and elution efficiency is high, and can carry out batch wash-out to biochip.
Accompanying drawing explanation
Also will be described in more detail the present invention with reference to accompanying drawing based on embodiment hereinafter.Wherein:
Fig. 1 is showing the structural representation of an embodiment of biochip washing device of the present invention.
Fig. 2 is showing the structural representation of an embodiment of the installing hole of the biochip washing device of Fig. 1.
Fig. 3 is showing the structural representation of another embodiment of the installing hole of the biochip washing device of Fig. 1.
Fig. 4 is showing the structural representation of an embodiment of the base of biochip washing device of the present invention.
Fig. 5 is showing the structural representation of another embodiment of biochip washing device of the present invention.
In the accompanying drawings, identical parts use identical Reference numeral.Accompanying drawing is not according to the scale of reality.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described.
Fig. 1 schematically illustrates the general structure of biochip washing device 1 (hereinafter referred to as device 1).
Device 1 comprises receiving member, and receiving member is configured with diapire 11, and to be arranged on diapire 11 and to surround the sidewall of diapire.As shown in Figure 1, the diapire 11 of receiving member is configured with installing hole 111.Biochip can be set in installing hole 111, with fixed biologically chip.Meanwhile, sidewall can surround the biochip be arranged in installing hole 111, plays certain protective effect to biochip.Such as, biochip here can be protein-chip or genetic chip etc.Here diapire can be porous test platform.
In addition, it should be noted that, biochip here should be and flows through formula chip.Flow through formula chip and there is closed bottom under normal laying state with load bearing fluid (such as, detecting liquid), and can flow out to make liquid at bottom formation opening when being subject to certain pressure.Its bearing part can be made up of nylon membrane, nitrocellulose filter etc.It is such as HPV genetic chip.This formula chip that flows through is known by those skilled in the art, does not add repeat at this.
Device 1 also comprises the piston piece 20 that contact sealed with the sidewall of receiving member, and piston piece 20 under the guiding of sidewall, can move along the direction of motion as illustrated by the arrows in fig. 1 in receiving member.Piston piece 20 is relative with diapire 11, thus can piston piece, between diapire and sidewall formed pressure chamber 17.
By making piston piece 20 move towards the diapire of receiving member, the volume of pressing chamber 17 can be reduced.Due to pressure be substantially seal or sealing, therefore press the reduction of chamber 17 volume to increase the pressure of pressing in chamber 17.After piston piece 20 moves a certain distance towards diapire 11, pressure increase in pressure chamber 17 is to the degree that can form opening in the bottom flowing through formula chip, the liquid be carried in biochip is made effectively to be squeezed out under pressure thus, thus can be clean by biochip wash-out, and make liquid residue to be there is on biochip.In detecting after biochip after device 1 wash-out of the application of the invention can use easily, and effectively can ensure the accuracy of testing result.Comparatively simple to the mode of operation of this device 1, thus conveniently can carry out wash-out to biochip efficiently.Meanwhile, if need to add multiple reactant liquor successively in container 4, the removal of each reactant liquor does not need to be undertaken by other transfer vessel yet, then can avoid the cross pollution of each reactant liquor in removal process.
As shown in Figure 1, installing hole 111 can be multiple, and multiple installing hole 111 is spaced from each other setting.Installing hole 111 can rectangular array arrangement as shown in Figure 1, also can arrange installing hole 111 with other rules or irregular arrangement mode as required.By arranging biochip in multiple installing hole 111, can realize carrying out wash-out to multiple biochip simultaneously, that is to say, batch wash-out can be carried out to biochip.
When being provided with multiple installing hole, installing hole can be configured to can be selectively opened or closed.Thus, when needs use one or more installing hole to arrange biochip, only need open the installing hole of respective numbers, and keep other installing holes to close.Thus, can prevent gas from leaking out from other installing holes, thus can ensure to press the air pressure in chamber to increase smoothly.
Fig. 2 and Fig. 3 schematically illustrates the concrete structure of installing hole 111.Installing hole 111 is through hole, with the downside making the liquid in biochip successfully can be expressed into diapire 11 along the direction of motion.Effectively can prevent from being arranged on by the device of this structure reactant liquor that the biochip in one of them installing hole 111 carries to flow in the biochip that other installing holes 111 carry, thus prevent the cross pollution between biochip.
In addition, the bottom of biochip can also be passed installing hole 111 and reach on the downside of diapire 11, can further facilitate liquid thus and be discharged.
Wherein, the diapire 11 shown in Fig. 2 in the region that it is provided with installing hole 111 downward the direction of piston piece (namely dorsad) extend, more to surround and to protect biochip.In addition, the diapire 11 shown in Fig. 3 is tabular, thus biochip can extend to the downside of diapire 11 easily, is discharged by liquid to facilitate.
As required, installing hole 111 here can be configured to the hole of circular port, square opening, tri-angle-holed, slotted eye, quincunx hole or other shapes be applicable to arbitrarily.
Here should be appreciated that, diapire can be configured to integrally, be formed with installing hole thereon.In addition, diapire also can be split type, and it comprises the coupling part be connected with sidewall, and the installing hole plate body that be connected detachable with this coupling part, and installing hole is formed on installing hole plate body.Here should be appreciated that, different installing hole plate bodys can be provided with the installing hole of varying number, difformity, different size, thus can change the quantity of installing hole, shape and size easily by replacing installing hole plate body.
In one embodiment, diapire 11 is connected with detachable between sidewall.Can be changed diapire 11 easily by this setup, to clean it easily and to safeguard.
Especially, biochip washing device 1 can be made to comprise multiple diapire 11.In this case, different diapires can be provided with the installing hole of difformity, size.Thus, the diapire (namely alternatively selecting the diapire be applicable to) that one of them can be selected to be applicable to is connected with sidewall, can select the required installing hole used thus.
Should be appreciated that, also as shown in Figure 5, first can will flow through formula chip and be set in non-enclosed chip reactive tank 4, then be set to carrying the non-enclosed chip reactive tank 4 flowing through formula chip in installing hole.The substructure of non-enclosed chip reactive tank 4 has osmosizing portion 6.In normal state (such as at ambient pressure), osmosizing portion 6 is closed state, to arrange liquid (such as reactant liquor or detect liquid) thus in non-enclosed chip reactive tank 4.And after pressing the pressure increase in chamber extremely to a certain degree, osmosizing portion 6 cannot carry the liquid in non-enclosed chip reactive tank 4 again, thus makes liquid to flow out from here, makes chip not be in and has in the environment of liquid.
Preferably, osmosizing portion 6 can be made up of nylon membrane, nitrocellulose filter etc.
Preferably, the area of section of the lower end of non-enclosed chip reactive tank is less than the area of section of upper end, to make non-enclosed chip reactive tank 4 can partially across installing hole 111 to downward-extension.Namely, non-enclosed chip reactive tank 4 can be arranged on installing hole 111.In installation process, the lower end of non-enclosed chip reactive tank 4 is through installing hole 111, and the upper end of non-enclosed chip reactive tank 4 is limited at the upside of installing hole 111.By this setup, can easily non-enclosed chip reactive tank 4 be installed and be pulled down, facilitate the reaction of biochip and the carrying out of elution action.
In order to be arranged on installing hole 111 easily by non-enclosed chip reactive tank 4, such as, non-enclosed chip reactive tank 4 can be configured to the structure with enlarging, to be stuck in installing hole 111 place.But non-enclosed chip reactive tank 4 is not limited to this version, can also be configured to other version.Such as, the upper end open place of non-enclosed chip reactive tank 4 is configured with the outer (not shown) extended radially outwardly, to be overlapped on the outer at installing hole 111 place.Or the outer wall of non-enclosed chip reactive tank 4 has tapering, be stuck in installing hole 111 place to make non-enclosed chip reactive tank 4.Thus, as long as the structure making non-enclosed chip reactive tank 4 can be installed to installing hole 111 place simply and easily all should fall into protection scope of the present invention.
As shown in Figure 1, the sidewall of receiving member comprises the first side wall 12 be fixedly linked with diapire 11, and second sidewall 13 that contact sealed with piston piece 20, and the first side wall is connected with the second sidewall is detachable.The first side wall 12 can keep being centered around around installing hole, and thus can when biochip is set in installing hole, protection biochip.In addition, contact because the second sidewall 13 and piston piece 20 are sealed and can disassemble with the first side wall, therefore when biochip is set in installing hole, or when biochip is taken out in installing hole, second sidewall and piston piece can not split, but keep the piston piece state that contact sealed with sidewall.Thus, effectively can avoid the regular fractionation between piston piece and receiving member and assembling, thus effectively ensure that the sealed stability contacted between piston piece with the second sidewall, and then effectively ensure that the pressure energy in pressure chamber effectively increases and liquid that biochip is carried can be extruded when piston piece is towards the diapire motion of receiving member.
As required, the first side wall 12 and the second sidewall 13 can be configured to the sidewall of cylindricality, taper, infundibulate or other shapes be applicable to arbitrarily respectively, meanwhile, ensure that the shape phase coadaptation of the first side wall 12 and the second sidewall 13 is being assembled together.Diapire can be configured to circle, square or other shapes be applicable to arbitrarily, needs to ensure that the shape of diapire and the first side wall adapts simultaneously.
Also be configured with seal in the contact position of the first side wall and the second sidewall, to make the first side wall can link together with the second sidewall is sealed, the liquid that the pressure energy further ensured in pressure chamber effectively increases and biochip is carried can be extruded.As shown in Figure 1, the first seal 14 can be constructed in the edge towards the second sidewall of the first side wall, construct the second seal 15 in the edge towards the first side wall of the second sidewall simultaneously.All can be configured to substantially in bowl-shape sealing ring at the first seal 14 and the second seal 15, the bowl-shape opening of the first seal is relative with the bowl-shape opening of the second seal.When making the first side wall near the second sidewall, first seal and the crimp mutually of the second seal energy, the air pressure outside the first seal and the second seal is made to be greater than air pressure in bowl-shape opening, thus can effectively the first seal and the second seal be sealed, and realize being tightly connected of the first side wall and the second sidewall thus.
As shown in Figure 1, force side 30 is configured with in the side in chamber 17 of pressing dorsad of piston piece 20.Promote piston piece 20 by applying pressure on force side 30, piston piece 20 is moved towards diapire 11.Here should be appreciated that, directly can be exerted pressure to force side 30 by manpower, also by other mechanical devices, be exerted pressure in force side.
Preferably, force side 30 is in receiving member outside.As shown in Figure 1, force side is in the overthe openings of receiving member.The size perpendicular to the direction of motion of force side 30 is greater than the size of opening perpendicular to the direction of motion of the sidewall formation of receiving member.This structure makes when exerting a force to pressure end, and piston piece can move to force side towards the diapire of receiving member and contact with the sidewall of receiving member.Now, because the size of force side is comparatively large, therefore when pressing down force side, force side can only contact with the upper edge of receiving member sidewall, and cannot enter in receiving member, thus limits the motion of piston piece, makes it move towards the diapire of receiving member again.
Preferably, the length along the direction of motion of piston piece can be made to be less than the length of sidewall along the direction of motion of receiving member.Like this, along when contacting on the sidewall of force side with receiving member, piston piece also cannot touch the diapire of receiving member, effectively prevent piston piece 20 thus and contacts with biochip, thus prevent biochip to be polluted, prevent biochip to be squeezed simultaneously.
Here should be appreciated that, should ensure the shape of piston piece 20, especially the shape of force side 30 and the shape of the first side wall 12 and the second sidewall 13 adapt with wash-out chip effectively.
In addition, device also can comprise housing 40 as shown in Figure 4.Housing 40 is configured with drain pan wall 41, and drain pan wall 41 is arranged at the side of the piston piece dorsad 20 of diapire 11, and the region corresponding with installing hole 111 of drain pan wall 41 is closed.Housing is also configured with the side shell wall 42 surrounding drain pan wall 41.Side shell wall 42 forms the space that can hold receiving member together with drain pan wall 41.When needs carry out incubation reaction to biochip, housing can be enclosed within outside receiving member, and the device 1 with housing is put in the device such as water-bath or drying box carry out incubation.The fluid that the setting of housing effectively prevent in the device such as water-bath or drying box directly contacts with biochip.The biochip be inserted in installing hole 111 preferably contacts with drain pan wall 41, thus enhances the efficiency of heat conduction to biochip, which thereby enhances the efficiency of incubation reaction.
Here should be appreciated that, when being provided with housing 40, directly can carry out the operation of biochip in this biochip washing device 1.That is, in this case, biochip washing device 1 is biochip reaction and washing device.Now, can effectively realize after biochip reaction, easily wash-out be carried out to biochip.And can realize after wash-out, directly in this device, operation is carried out to biochip.So can realize reaction repeatedly and elution action, to such an extent as to the carrying out of the processes such as greatly convenient test or experiment.
More preferably, as shown in Figure 4, drain pan wall 41 is configured with the groove 411 of opening towards installing hole.The position of groove is corresponding with the position of installing hole, and the shape bottom the shape of groove and biochip adapts.When being inserted in installing hole by biochip, biochip can be inserted in groove and to fit with the surface of groove.Thus, when carrying out incubation reaction, temperature can be transmitted on biochip more equably, to improve the validity of incubation reaction.
Here should be appreciated that, when base plate 11 is configured to structure as shown in Figure 3, can also convenient biochip be inserted in groove.In addition, drain pan wall 41 (especially it is provided with the part of groove 411) here can be made up of resilient material, can contact with the surface of groove better to make biochip.
In addition, comparatively stable in order to ensure the combination of housing and receiving member, also can be configured with pin 16 on diapire 11, on drain pan wall 41, be configured with corresponding jack 44 simultaneously.Pin 16 can be inserted in jack 44, relatively rotates to prevent receiving member and housing.In addition, pin can also with jack interference fit, unpredictably deviate from housing to prevent receiving member.Pin is multiple (such as, four) preferably, to make the combination between housing and receiving member more stable.
Also can be configured with foot 43 on drain pan wall 41.Foot 43 is multiple (such as, four) preferably.Housing stably stands in platform or plane by foot, conveniently carries out incubation reaction to biochip.
In addition, jack may extend in foot 43.Thus, when pin 16 is inserted in jack, is actually and pin 16 is inserted in drain pan wall 41 and foot 43.By this structure, more easily receiving member and housing can be entrenched togather, and improve the structural stability of device 1 further.
As required, pin 16 can be configured to rod as shown in Figure 4 or other shapes be applicable to arbitrarily.Jack 44 is configured with the shape adapted with pin 16.In addition, foot 43 also can the rod be configured to as shown in Figure 4 or other shapes be applicable to arbitrarily as required.When pin 16 needs to be inserted in foot 43, need ensure that foot has the size holding pin.
Said apparatus 1 can effectively and easily remove the liquid that biochip carries, and effectively can ensure authenticity and the validity of the result in the detection afterwards of this biochip thus.
Although invention has been described with reference to preferred embodiment, without departing from the scope of the invention, various improvement can be carried out to it and parts wherein can be replaced with equivalent.Especially, only otherwise there is structural hazard, the every technical characteristic mentioned in each embodiment all can combine in any way.The present invention is not limited to specific embodiment disclosed in literary composition, but comprises all technical schemes fallen in the scope of claim.
Claims (10)
1. a biochip washing device, described biochip, for flowing through formula chip, is characterized in that, described biochip washing device comprises:
Receiving member, described receiving member comprises diapire and surrounds the sidewall of described diapire, and on the diapire of described receiving member, penetration type is configured with the installing hole for arranging biochip, and
Can extend into the piston piece in described receiving member, described piston piece contacts with described sidewall movable sealed, at described piston piece, forms pressure chamber between diapire and sidewall,
Wherein, described piston piece can towards described diapire motion to increase the pressure in described pressure chamber.
2. biochip washing device according to claim 1, it is characterized in that, described sidewall comprises the first side wall be fixedly linked with described diapire, and second sidewall that contact sealed with described piston piece, and described the first side wall is connected with described second sidewall detachable-type sealed.
3. biochip washing device according to claim 2, it is characterized in that, be configured with the first seal in the edge towards described second sidewall of described the first side wall, be configured with the second seal in the edge towards described the first side wall of described second sidewall
Described first seal and the second seal contact with by the first side wall with the second sidewall is sealed links together.
4. the biochip washing device device according to any one of Claim 1-3, is characterized in that, described installing hole is multiple, and each described installing hole can be selectively opened or closed separately.
5. the biochip washing device device according to any one of claim 1 to 4, is characterized in that, the one end in the described dorsad pressure chamber of described piston piece is configured with force side,
By pressing down described piston piece to described force side applying pressure energy, described piston piece is moved towards described diapire.
6. biochip washing device device according to claim 5, it is characterized in that, described piston piece dorsad described pressure chamber extends to make described force side reach outside described sidewall, and the size perpendicular to the direction of motion of described force side is greater than the size of opening perpendicular to the direction of motion of described sidewall formation.
7. the biochip washing device device according to any one of claim 1 to 6, is characterized in that, described diapire and the detachable connection of sidewall.
8. the biochip washing device device according to any one of claim 1 to 7, it is characterized in that, also comprise the housing surrounding described receiving member, described housing comprises the drain pan wall of the side of the described dorsad piston piece being arranged at described diapire, and to be connected with described drain pan wall and to surround the side shell wall of described sidewall
Described drain pan wall is what close in the region corresponding with described installing hole.
9. biochip washing device device according to claim 8, is characterized in that, in the region corresponding with described installing hole of described drain pan wall, be configured with the groove of opening towards described installing hole,
The described biochip be inserted in installing hole can contact with the surface of described groove.
10. biochip washing device device according to claim 8 or claim 9, is characterized in that there is pin towards described drain pan wall is extended on described diapire,
The jack corresponding with described pin is configured with in not corresponding with the described installing hole region of described drain pan wall,
Described pin can be inserted in described jack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510711015.3A CN105235253B (en) | 2015-10-28 | 2015-10-28 | Biological chip eluting device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510711015.3A CN105235253B (en) | 2015-10-28 | 2015-10-28 | Biological chip eluting device |
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| CN105235253A true CN105235253A (en) | 2016-01-13 |
| CN105235253B CN105235253B (en) | 2017-05-17 |
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| CN201510711015.3A Active CN105235253B (en) | 2015-10-28 | 2015-10-28 | Biological chip eluting device |
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| US20030086830A1 (en) * | 2001-10-12 | 2003-05-08 | Becton Dickinson And Company | Method and apparatus for transporting biological samples |
| US20060078474A1 (en) * | 2004-03-02 | 2006-04-13 | Nippi, Inc. | Instrument and method for breaking-up sample |
| WO2012001607A1 (en) * | 2010-06-29 | 2012-01-05 | Yadav, Omprakash | Disposable homogenizer kit |
| US20130333157A1 (en) * | 2012-06-14 | 2013-12-19 | Innoquest, Inc. | Handheld Nozzle Cleaning Apparatus |
| CN104289461A (en) * | 2014-09-30 | 2015-01-21 | 苏州速腾电子科技有限公司 | Jig for cleaning chip |
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2015
- 2015-10-28 CN CN201510711015.3A patent/CN105235253B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030086830A1 (en) * | 2001-10-12 | 2003-05-08 | Becton Dickinson And Company | Method and apparatus for transporting biological samples |
| US20060078474A1 (en) * | 2004-03-02 | 2006-04-13 | Nippi, Inc. | Instrument and method for breaking-up sample |
| WO2012001607A1 (en) * | 2010-06-29 | 2012-01-05 | Yadav, Omprakash | Disposable homogenizer kit |
| US20130333157A1 (en) * | 2012-06-14 | 2013-12-19 | Innoquest, Inc. | Handheld Nozzle Cleaning Apparatus |
| CN104289461A (en) * | 2014-09-30 | 2015-01-21 | 苏州速腾电子科技有限公司 | Jig for cleaning chip |
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| CN105235253B (en) | 2017-05-17 |
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