CN103954479A - Sampling and reagent adding apparatus capable of eliminating reagent residue - Google Patents
Sampling and reagent adding apparatus capable of eliminating reagent residue Download PDFInfo
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- CN103954479A CN103954479A CN201410145696.7A CN201410145696A CN103954479A CN 103954479 A CN103954479 A CN 103954479A CN 201410145696 A CN201410145696 A CN 201410145696A CN 103954479 A CN103954479 A CN 103954479A
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- reagent
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- newel
- sampling
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Abstract
The invention relates to an improved device of a reagent adding apparatus, and discloses a sampling and reagent adding apparatus capable of eliminating reagent residue. The sampling and reagent adding apparatus comprises, from the lower part to the upper part, a quantitative capillary (1), an installation rack (4), a reagent box body (2), and a piston (3); the quantitative capillary (1) is immobilized at the lower part of the reagent box body (2) via the rod-shaped installation rack (4); the reagent box body (2) is a cylinder with an upward open; a vertical central column (2c) is arranged in the middle part of the reagent box body, the top of the vertical central column (2c) is provided with a needle point; a base plate (2b) in the cylinder, and the periphery of the central column (2c) are provided with a plurality of liquid flow holes (2a); the piston (3) is inserted into the cylinder with the upward open on the upper part of the reagent box body (2); the lower part of the piston (3) is provided with a reagent cabin (3a) upward; in the reagent cabin (3a), reagent sealing is realized via a sealing membrane (3b) arranged at the lower part of the reagent cabin; the plurality of liquid flow holes (2a) on the base plate (2b) are arranged inside the range of opens of reaction cups or reaction tubes; the reagent sealed in the reagent cabin of the piston will flow downward through gaps of the sealing membrane, and flow through the liquid flow holes on the periphery of the central column into the reaction cups or the reaction tubes completely, so that accurate test results can be obtained.
Description
Technical field
The present invention relates to a kind of improved device of reagent adding device, especially a kind of improved device of integrated quantitative sampling reagent adding device.
Background technology
Current detection present situation, first in reaction cup, add dilution (A) 500uL, then use pipettor sampling (B) 2uL, after sampling, sample is added in reaction cup, shake reaction cup mixes sample and dilution, after the pipettor that need to change again 50tlL or 100tlL range adds 50tlL reagent (C) to mix, detects.Whole operating process at least needs to use the pipettor of two different ranges, and operating process is more complicated, and especially larger for the following sample sampling error of 2uL, cost is higher.
For above phenomenon, in recent years released the patent No. 201010539091.8 " a kind of integrated quantitative sampling reagent adding device ", the patent No. 201120293289.2 " Integral sample collecting injection device " and the patent No. 201220584650.1 " a kind of structure-improved of quantitative sampling reagent adding device ", basic structure is identical with function, following structure is disclosed, comprise quantitative capillary tube, support, reagent box body, piston and snap ring, it is characterized in that: quantitative capillary tube is assigned on support, support and reagent box body are integral type, support is positioned at one end of reagent box body, the reagent box body other end is equipped with piston, agent bin in described piston encapsulates reagent by sealer, and support afterbody has the taper pin of offering center pit, by pressing the sealer of piston by the broken agent bin of acupuncture of support afterbody, in the time continuing to press lower piston, the reagent in agent bin flows in reaction cup by the center pit of support, completes quantitative reagent and adds reaction cup.
But known, the taper pin of offering center pit is coniform, sealer is plastic sheeting, pin plastic sheeting in the time puncturing sealer can evenly tightly not expand from small to large along needle point, tear phenomenon and have, hole can be torn, and occurs breach, and now the reagent in agent bin can flow out from the notched slot tearing.But, the unique outlet of prior art reagent is to flow through in center pit inflow reaction cup or reaction tube in the hole of offering on needle point, therefore tear from sealer the reagent that gap and openning flow out and can flow into and stockpile the surrounding space at reagent box body and center pit, again that the hole from needle point flows into center pit, therefore random, that cannot know accumulates reagent residual and can have a strong impact on measuring accuracy.Especially, when test, the needle point of support is upward, accumulates the more impossible hole that climbs into from lower to upper needle point top of reagent residual and flows out, and this disadvantage prior art cannot overcome.But for the precision that improves test must change.
Summary of the invention
The object of the invention is to for above-mentioned the deficiencies in the prior art, provide one can eliminate reagent residual, improve the quantitative sampling reagent adding device of measuring accuracy.
Object of the present invention is realized by following technical scheme.
Eliminate a sampling reagent adding device for reagent residual, comprise quantitative capillary tube, erecting frame, reagent box body and piston from bottom to top, it is characterized in that:
Described quantitative capillary tube is fixed on the bottom of reagent box body by shaft-like erecting frame;
Reagent box body is the cylinder of opening upwards, in the central authorities of cylinder, vertical newel is set, and newel top is needle point, on the base plate of cylinder interior, offers several fluid holes around newel;
In the unlimited cylinder in reagent box body top, insert the cylindric piston that can relatively move up and down; Agent bin is upwards offered in the bottom of piston, in agent bin, encapsulates reagent by the sealer of bottom;
At described reagent box plate bottom placing response cup or reaction tube, several fluid holes on base plate are positioned at the opening scope of reaction cup or reaction tube.
Adopt the technical program, reagent box body is the cylinder of opening upwards, in the central authorities of cylinder, vertical newel is set, and newel top is needle point.Agent bin is upwards offered in the bottom of piston, in agent bin, encapsulates reagent by the sealer of bottom; When pressing piston, piston moves down, the needle point at newel top can puncture sealer, packed reagent can flow out downwards from the breach of sealer, flow into the appearance of newel, trickle to reagent box body bottom, the space between cylinder and newel, owing to offering several fluid holes around newel, reagent just flows out reagent box plate downwards from these fluid holes.Again due to " several fluid holes on base plate are positioned at the opening scope of reaction cup or reaction tube ", therefore these reagent just all flow in reaction cup or reaction tube, reagent can be all, up hill and dale from fluid hole stream only under self gravitation effect, the reagent of having avoided prior art to accumulate around newel becomes the drawback that raffinate cannot flow out, can ensure correctly, exactly with dilution, and the sample being gathered by quantitative capillary tube precisely mixes, obtain accurate test result.
Further, described newel is hollow tubular, offers through hole and be communicated with hollow tubular on the needle point of newel top.
Further, between described reagent box body and described piston, configure annular snap ring, described snap ring is step-like, and first half inwall mates with the cylinder outer wall of reagent box body, and latter half inwall mates with piston outer wall.
Further, offer groove in top tapered needle surface and the tube wall appearance of described newel, groove direction is for from up to down.
Further, the top tapered needle point of described newel and tube wall are vertically radial schistose texture of stretching out of multi-disc.
Beneficial effect of the present invention, determined by design feature of the present invention, the reagent being encapsulated in piston agent bin can flow out downwards from the breach of sealer, flow into the appearance of newel, trickle to reagent box body bottom, the fluid hole of offering from the surrounding of newel flows in reaction cup or reaction tube all, up hill and dale, can obtain accurate test result.Thoroughly changed residual amount of reagent in prior art uncontrollable, can not survey, disadvantage that can not emptying, and the method changing is simple, feasible, reliable results.
Brief description of the drawings
Fig. 1 is a kind of embodiment of sampling reagent adding device that the present invention eliminates reagent residual, the structure configuration map of bottom placing response cup test tube;
Fig. 2 is the another kind of embodiment of sampling reagent adding device that the present invention eliminates reagent residual, configures the structure configuration map of snap ring between reagent box body and piston;
Fig. 3 is another embodiment of sampling reagent adding device that the present invention eliminates reagent residual, and newel is hollow tubular, offers the structural drawing that through hole is communicated with hollow tubular on the needle point of top;
Fig. 4 is the structural drawing of a kind of quantitative sampling reagent adding device of prior art.
In figure:
The 1st, quantitative capillary tube, the 2nd, reagent box body, 2a are that fluid hole, 2b are that base plate, 2c are newels, the 3rd, piston, 3a is that agent bin, 3b are sealers, the 4th, erecting frame, 4a are that needle point, 4b are pipes, the 5th, snap ring.
Embodiment
Further describe structure of the present invention below in conjunction with accompanying drawing.
Eliminate a sampling reagent adding device for reagent residual, comprise quantitative capillary tube 1, erecting frame 4, reagent box body 2 and piston 3 from bottom to top,
Described quantitative capillary tube 1 is fixed on the bottom of reagent box body 2 by shaft-like erecting frame 4;
Reagent box body 2 is the cylinder of opening upwards, in the central authorities of cylinder, vertical newel 2c is set, and newel 2c top is needle point, on the base plate 2b of cylinder interior, offers several fluid holes 2a around newel 2c;
In the unlimited cylinder in reagent box body 2 tops, insert the cylindric piston 3 that can relatively move up and down; Agent bin 3a is upwards offered in the bottom of piston 3, in agent bin 3a, encapsulates reagent by the sealer 3b of bottom;
At described reagent box body 2 base plate 2b bottom placing response cup or reaction tubes, several fluid holes 2a on base plate 2b is positioned at the opening scope of reaction cup or reaction tube.
Described newel 2c is hollow tubular, offers through hole and be communicated with hollow tubular on the needle point of newel 2c top.On reagent box body 2 base plate 2b, offer on the basis of fluid hole 2a, then allow the newel 2c be hollow tubular, offer through hole and be communicated with hollow tubular on the needle point of top, dual trickling reagent can accelerate to flow into the speed of reaction cup or reaction tube.
Between described reagent box body 2 and described piston 3, configure annular snap ring 5, described snap ring 5 is step-like, and first half inwall mates with the cylinder outer wall of reagent box body 2, and latter half inwall mates with piston 3 outer walls.The structure of reserve part prior art sampling reagent adding device, can utilize existing parts, reduces the cost of remodeling, the remodeling of favourable part prior art products.
Top tapered needle surface and tube wall appearance at described newel 2c are offered groove, and groove direction is for from up to down.Reagent in agent bin can trickle downwards along groove, can guarantee that in the agent bin 3a of piston 3, reagent solution flows out from agent bin, and stream is clean.
The top tapered needle point of described newel 2c and tube wall are vertically radial schistose texture of stretching out of multi-disc.Described schistose texture can be four, six etc., just as the configuration of heat radiation sheet, more easily scratches sealer, allows the reagent in agent bin flow out.
Claims (5)
1. eliminate a sampling reagent adding device for reagent residual, comprise quantitative capillary tube (1), erecting frame (4), reagent box body (2) and piston (3) from bottom to top, it is characterized in that:
Described quantitative capillary tube (1) is fixed on the bottom of reagent box body (2) by shaft-like erecting frame (4);
Reagent box body (2) is the cylinder of opening upwards, in the central authorities of cylinder, vertical newel (2c) is set, newel (2c) top is needle point, base plate (2b) in cylinder interior is upper, offers several fluid holes (2a) around newel (2c);
In the unlimited cylinder in reagent box body (2) top, insert the cylindric piston (3) that can relatively move up and down; Agent bin (3a) is upwards offered in the bottom of piston (3), in agent bin (3a), encapsulates reagent by the sealer (3b) of bottom;
At described reagent box body (2) base plate (2b) bottom placing response cup or reaction tube, several fluid holes (2a) on base plate (2b) are positioned at the opening scope of reaction cup or reaction tube.
2. eliminate according to claim 1 the sampling reagent adding device of reagent residual, it is characterized in that described newel (2c) is hollow tubular, on the needle point of newel (2c) top, offer through hole and be communicated with hollow tubular.
3. eliminate according to claim 1 the sampling reagent adding device of reagent residual, it is characterized in that configuring annular snap ring (5) between described reagent box body (2) and described piston (3), described snap ring (5) is step-like, first half inwall mates with the cylinder outer wall of reagent box body (2), and latter half inwall mates with piston (3) outer wall.
4. eliminate according to claim 1 the sampling reagent adding device of reagent residual, it is characterized in that offering groove in top tapered needle surface and the tube wall appearance of described newel (2c), groove direction is for from up to down.
5. eliminate according to claim 1 the sampling reagent adding device of reagent residual, it is characterized in that the top tapered needle point of described newel (2c) and tube wall are vertically radial schistose texture of stretching out of multi-disc.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410145696.7A CN103954479B (en) | 2014-04-11 | 2014-04-11 | A kind of sampling reagent adding device eliminating reagent residual |
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| CN201410145696.7A CN103954479B (en) | 2014-04-11 | 2014-04-11 | A kind of sampling reagent adding device eliminating reagent residual |
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| CN103954479B CN103954479B (en) | 2016-07-06 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104502150A (en) * | 2014-12-16 | 2015-04-08 | 武汉海王新能源工程技术有限公司 | Radioactive liquid sample sampling device and radioactive liquid sample sampling method for nuclear power station |
| CN107144460A (en) * | 2017-06-23 | 2017-09-08 | 张雪峰 | Just sample processor |
| CN108414263A (en) * | 2018-05-04 | 2018-08-17 | 上海透景诊断科技有限公司 | Fecal sample integral collecting device and method |
| CN109925966A (en) * | 2019-04-01 | 2019-06-25 | 丹娜（天津）生物科技有限公司 | A kind of filling of reagent and reaction unit |
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| US5307696A (en) * | 1991-03-25 | 1994-05-03 | Cogema-Compagnie Generale Des Matieres Nucleires | Liquid sampling head having a removable needle body immersed in a cavity |
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| CN102072949A (en) * | 2010-11-11 | 2011-05-25 | 郝书顺 | Integrated quantitative sampling and reagent adding device |
| CN202204706U (en) * | 2011-08-12 | 2012-04-25 | 石家庄禾柏生物技术股份有限公司 | Integral sample collecting injection device |
| CN202903768U (en) * | 2012-11-07 | 2013-04-24 | 上海奥普生物医药有限公司 | Improved structure of quantitative sampling reagent feed device |
| CN203132865U (en) * | 2012-12-25 | 2013-08-14 | 南京普朗医用设备有限公司 | Puncturing piston type sample feeding and sampling device |
| CN204008218U (en) * | 2014-04-11 | 2014-12-10 | 上海地慧光电科技有限公司 | A kind of solid pillar sampling reagent adding device |
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2014
- 2014-04-11 CN CN201410145696.7A patent/CN103954479B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5307696A (en) * | 1991-03-25 | 1994-05-03 | Cogema-Compagnie Generale Des Matieres Nucleires | Liquid sampling head having a removable needle body immersed in a cavity |
| CN1293950A (en) * | 1999-10-20 | 2001-05-09 | 吴振东 | High-speed pneumatically osmotic composite cotton swab for medical purpose or daily use |
| CN102072949A (en) * | 2010-11-11 | 2011-05-25 | 郝书顺 | Integrated quantitative sampling and reagent adding device |
| CN202204706U (en) * | 2011-08-12 | 2012-04-25 | 石家庄禾柏生物技术股份有限公司 | Integral sample collecting injection device |
| CN202903768U (en) * | 2012-11-07 | 2013-04-24 | 上海奥普生物医药有限公司 | Improved structure of quantitative sampling reagent feed device |
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| CN204008218U (en) * | 2014-04-11 | 2014-12-10 | 上海地慧光电科技有限公司 | A kind of solid pillar sampling reagent adding device |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104502150A (en) * | 2014-12-16 | 2015-04-08 | 武汉海王新能源工程技术有限公司 | Radioactive liquid sample sampling device and radioactive liquid sample sampling method for nuclear power station |
| CN107144460A (en) * | 2017-06-23 | 2017-09-08 | 张雪峰 | Just sample processor |
| CN108414263A (en) * | 2018-05-04 | 2018-08-17 | 上海透景诊断科技有限公司 | Fecal sample integral collecting device and method |
| CN109925966A (en) * | 2019-04-01 | 2019-06-25 | 丹娜（天津）生物科技有限公司 | A kind of filling of reagent and reaction unit |
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| Publication number | Publication date |
|---|---|
| CN103954479B (en) | 2016-07-06 |
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Owner name: SHANGHAI UPPER BIO-TECH PHARMA CO., LTD. Free format text: FORMER OWNER: SHANGHAI DIHUI PHOTOELECTRIC SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20150311 |
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Effective date of registration: 20150311 Address after: 201201 Shanghai City, Pudong New Area Ruiqinglu No. 526 Applicant after: Shanghai Upper Bio-tech Pharma Co., Ltd. Address before: 200237, Shanghai, Minhang District Hongmei South Road, No. 1755, a layer of AB1095 room Applicant before: SHANGHAI DIHUI PHOTOELECTRIC TECHNOLOGY CO., LTD. |
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Effective date of registration: 20160810 Address after: 200237, Shanghai, Minhang District Hongmei South Road, No. 1755, a layer of AB10 room Patentee after: SHANGHAI DIHUI PHOTOELECTRIC TECHNOLOGY CO., LTD. Address before: 201201 Shanghai City, Pudong New Area Ruiqinglu No. 526 Patentee before: Shanghai Upper Bio-tech Pharma Co., Ltd. |
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Effective date of registration: 20180321 Address after: No. 33, highway 4633, Pudong New Area Academy of Shanghai, Shanghai Patentee after: Shanghai Wangxin Bean Product Apparatus Co., Ltd. Address before: 200237, Shanghai, Minhang District Hongmei South Road, No. 1755, a layer of AB10 room Patentee before: SHANGHAI DIHUI PHOTOELECTRIC TECHNOLOGY CO., LTD. |