CN105233323A - Medical sponge with effect of promoting organism tissue growth and manufacturing method of medical sponge - Google Patents
Medical sponge with effect of promoting organism tissue growth and manufacturing method of medical sponge Download PDFInfo
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Abstract
The invention discloses a medical sponge with an effect of promoting the organism tissue growth. The medical sponge is prepared from the following components in parts by mass: 6 to 11 parts of white gourd, 7 to 12 parts of adder tongue herb, 9 to 13 parts of viola japonica, 10 to 16 parts of cacumen biotae, 10 to 13 parts of pigeon pea, 4 to 8 parts of horse bezoar, 6 to 12 parts of radix isatidis, 5 to 10 parts of angelica dahurica, 8 to 13 parts of solanum nigrum, 40 to 60 parts of chitin and a proper amount of fibrinogen. An obtained product has the advantages that a good hemostatic effect is achieved; the regenerated granulation tissue growth can be effectively promoted; good biocompatibility is realized; the degradation is easy; and no pollution is caused.
Description
Technical field
The present invention relates to field of medical products, particularly relate to and there is medical sponge and the method for making that promotion when injected organism tissue grows effect.
Background technology
Medical sponge is medical treatment consumptive materials conventional in a kind of operation, has and serves as implant, and hemostasis, prevents the effects such as adhesion.Along with the development of China's Medical Technology, the efficacy requirements for medical sponge is more and more higher, and therefore develop the medical sponge of new material, new effect, it is necessary for improving operating safety, strengthening postoperation recovery quality.
Publication No. CN104906628A(application number 201510262705.5) Chinese patent literature disclose a kind of preparation method of anti-inflammation medical sponge, its preparation method comprises the following steps: take each component by weight ratio; The above-mentioned each component taken be placed in agitator and stir, speed of agitator is 50-100rpm, and mixing time is 30min; The mixed liquor obtained is poured in film formation device, is placed in lyophilization 15h-35h in vacuum freeze drier, obtains anti-inflammation medical sponge.Publication No. CN103736134A(application number 201310743416.8) Chinese patent literature disclose a kind of medical sponge dressing, described medical sponge dressing comprises polyvinyl alcohol, Aloe and antibacterial, described polyvinyl alcohol is three-dimensional netted, described Aloe and antibacterial are carried on surface and the inside of described polyvinyl alcohol, described polyvinyl alcohol, Aloe and antibacterial form the composite with micropore, and the quality of described polyvinyl alcohol, Aloe and antibacterial accounts for 79% ~ 94.5%, 5% ~ 20% and 0.5% ~ 1% of described composite gross mass respectively.Publication No. CN101954115A(application number 201010516376.X) Chinese patent literature disclose a kind of medical antibacterial sponge dressing, primarily of PVAC polyvinylalcohol, nanometer silver, formaldehyde, acid, fibroin albumen, foaming agent is polycondensation reaction in aqueous, prepare according to the following steps: get a certain amount of PVA, foaming agent, fibroin albumen mix with deionized water, mechanical agitation, prepares mixed solution, stir, and slowly heat; Stirring certain hour, add formalin, continue to stir certain hour, then add acid solution, under the effect of acid condition and formaldehyde, there is aldolisation in PVA and fibroin albumen; Adjustment mixing speed is to stopping; Curing molding; The demoulding is washed; Extrusion dehydration, then immerses in nanometer silver solution and shakes certain hour; Lyophilization and machine-shaping.
Medical sponge in such scheme still has deficiency in the healing of promotion when injected organism tissue, utilizes the good characteristic of chitin self, is aided with Effective Component of Chinese Medicine, can improve deficiency in this respect further.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, wide the having of the use safety suitability promotes that when injected organism tissue grows medical sponge and the method for making of effect.
Technical scheme of the present invention is:
Have and promote that when injected organism tissue grows the medical sponge of effect, be prepared from primarily of following raw materials according, be mass parts: Fructus Benincasae 6-11; Herba Ophioglossi 7-12; Herba Violae japonicae 9-13; Cacumen Platycladi 10-16; Semen Cajani 10-13; Calculus Equi 4-8; Radix Isatidis 6-12; Radix Angelicae Dahuricae 5-10; Herba Solani Nigri 8-13; Chitin 40-60; Fibrinogen is appropriate.
Preferred version is, Fructus Benincasae 7-10; Herba Ophioglossi 9-10; Herba Violae japonicae 10-12; Cacumen Platycladi 12-14; Semen Cajani 11-12; Calculus Equi 5-7; Radix Isatidis 8-10; Radix Angelicae Dahuricae 6-9; Herba Solani Nigri 9-12; Chitin 45-55; Fibrinogen is appropriate.
More preferably, Fructus Benincasae 8.5; Herba Ophioglossi 9.5; Herba Violae japonicae 11; Cacumen Platycladi 13; Semen Cajani 11.5; Calculus Equi 6; Radix Isatidis 9; The Radix Angelicae Dahuricae 7.5; Herba Solani Nigri 10.5; Chitin 50; Fibrinogen is appropriate.
The preparation method of described medical sponge, step is as follows:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 12-20 minute is (preferred: moistening 14-18 minute; Be more preferably: moistening 16 minutes), add decocting in water to boiling, filter, collect filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fry 6-14 minute (preferred: slow fire stir-fries 8-12 minute; Be more preferably: slow fire stir-fries 10 minutes), drench into vinegar water infiltration, change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 8-16 minute (preferably: soak 10-14 minute; Be more preferably: soak 12 minutes), taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add water boil, continue 12 minutes, add step (2) (3) made crude drug again, change little fire and decoct 20-28 minute (preferably: little fire decocts 22-26 minute; Be more preferably: little fire decocts 24 minutes), collecting by filtration filtrate, and mix with step (1) gained filtrate, heating is concentrated, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stir, make the chitin solution (preferred: to make the chitin solution that concentration is 2%) that concentration is 1%-3%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, be sub-packed in container, add Fibrinogen again, lyophilization, makes spongy layer, by the mixed liquid dipping 6-10 minute of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
The preparation method of described medical sponge, step (1) amount of water is that the 4-6 of Fructus Benincasae quality is doubly (preferred: amount of water is 4.5-5.5 times of Fructus Benincasae quality; Be more preferably: amount of water is 5 times of Fructus Benincasae quality).
The preparation method of described medical sponge, step (2) is drenched into vinegar water infiltration 5-15 minute (preferred: to drench into vinegar water infiltration 8-12 minute; Be more preferably: drench into vinegar water infiltration 10 minutes).
The preparation method of described medical sponge, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
The preparation method of described medical sponge, it is (preferred: the concentrated 12-18 minute of heating that step (4) heating concentrates 10-20 minute; Be more preferably: concentrated 15 minutes of heating).
The preparation method of described medical sponge, the thickness of step (5) spongy layer is that 4-6mm(is preferred: the thickness of spongy layer is 5mm).
The preparation method of described medical sponge, step (5) was by spongy layer ammonia and methanol mixed liquid dipping 7-9 minute (preferred: the mixed liquid dipping 8 minutes by spongy layer ammonia and methanol).
Provided by the invention have the medical sponge scientific formulation that promotion when injected organism tissue grows effect, and preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, haemostatic effect is good, can effectively promote that new granulation tissue grows;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of reducing swelling and alleviating pain, removing pathogenic heat from blood and toxic substance from the body;
3, products obtained therefrom of the present invention, has good biocompatibility, easily degrades, pollution-free.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1have and promote that when injected organism tissue grows the medical sponge of effect, be prepared from (every part of 10g) primarily of following raw materials according: 6 parts, Fructus Benincasae, Herba Ophioglossi 7 parts, Herba Violae japonicae 9 parts, Cacumen Platycladi 10 parts, Semen Cajani 10 parts, Calculus Equi 4 parts, Radix Isatidis 6 parts, the Radix Angelicae Dahuricae 5 parts, Herba Solani Nigri 8 parts, chitin 40 parts, human fibrinogen's appropriate (purchased from Shanghai Institute of Biological Products Co., Ltd., authentication code is the accurate word S10970080 of traditional Chinese medicines).Above-mentioned have promote that the preparation method that when injected organism tissue grows the medical sponge of effect is:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 12 minutes, the decocting in water adding Fructus Benincasae quality 4 times, to boiling, filters, and collects filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fries 6 minutes, drenches into vinegar water infiltration 5 minutes, and change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 8 minutes, taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add the water boil of boiled crude drug quality 5 times, continue 12 minutes, then add step (2) (3) made crude drug, change little fire and decoct 20 minutes, collecting by filtration filtrate, and mix with step (1) gained filtrate, concentrated 10 minutes of heating, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stirs, make the chitin solution that concentration is 1%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, is sub-packed in container, add Fibrinogen again, lyophilization, makes the spongy layer that thickness is 4mm, by the mixed liquid dipping 6 minutes of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
embodiment 2have and promote that when injected organism tissue grows the medical sponge of effect, be prepared from (every part of 10g) primarily of following raw materials according: 11 parts, Fructus Benincasae, Herba Ophioglossi 12 parts, Herba Violae japonicae 13 parts, Cacumen Platycladi 16 parts, Semen Cajani 13 parts, Calculus Equi 8 parts, Radix Isatidis 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Solani Nigri 13 parts, chitin 60 parts, human fibrinogen's appropriate (purchased from Shanghai Institute of Biological Products Co., Ltd., authentication code is the accurate word S10970080 of traditional Chinese medicines).Above-mentioned have promote that the preparation method that when injected organism tissue grows the medical sponge of effect is:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 20 minutes, the decocting in water adding Fructus Benincasae quality 6 times, to boiling, filters, and collects filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fries 14 minutes, drenches into vinegar water infiltration 15 minutes, and change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 16 minutes, taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add the water boil of boiled crude drug quality 8 times, continue 12 minutes, then add step (2) (3) made crude drug, change little fire and decoct 28 minutes, collecting by filtration filtrate, and mix with step (1) gained filtrate, concentrated 20 minutes of heating, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stirs, make the chitin solution that concentration is 3%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, is sub-packed in container, add Fibrinogen again, lyophilization, makes the spongy layer that thickness is 6mm, by the mixed liquid dipping 10 minutes of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
Typical case: xxx, male, 63 years old.Medical history: accidentally hurt when patient works, because wound is comparatively large, amount of bleeding is gone to see a doctor more, and general sponge cannot quick-acting haemostatic powder, then use this example gained medical sponge instead, within five minutes, blood just stops, after wrapping, wound pain alleviates, and patient's wound healing after ten days, without cicatrix.
embodiment 3have and promote that when injected organism tissue grows the medical sponge of effect, be prepared from (every part of 10g) primarily of following raw materials according: 7 parts, Fructus Benincasae, Herba Ophioglossi 9 parts, Herba Violae japonicae 10 parts, Cacumen Platycladi 12 parts, Semen Cajani 11 parts, Calculus Equi 5 parts, Radix Isatidis 8 parts, the Radix Angelicae Dahuricae 6 parts, Herba Solani Nigri 9 parts, chitin 45 parts, human fibrinogen's appropriate (purchased from Shanghai Institute of Biological Products Co., Ltd., authentication code is the accurate word S10970080 of traditional Chinese medicines).Above-mentioned have promote that the preparation method that when injected organism tissue grows the medical sponge of effect is:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 14 minutes, the decocting in water adding Fructus Benincasae quality 4.5 times, to boiling, filters, and collects filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fries 8 minutes, drenches into vinegar water infiltration 8 minutes, and change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 10 minutes, taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add the water boil of boiled crude drug quality 6 times, continue 12 minutes, then add step (2) (3) made crude drug, change little fire and decoct 22 minutes, collecting by filtration filtrate, and mix with step (1) gained filtrate, concentrated 12 minutes of heating, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stirs, make the chitin solution that concentration is 1%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, is sub-packed in container, add Fibrinogen again, lyophilization, makes the spongy layer that thickness is 4mm, by the mixed liquid dipping 7 minutes of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
Typical case: xxx, women, 35 years old.Medical history: patient is because of carelessness by fire burn, skin epidermal cells is seriously impaired, this example gained medical sponge is used in operation process, soaking effect is good, non-stimulated to skin, between patient's convalescent period, for new granulation tissue's adhesion, healing time obviously shortens, substantially without cicatrization after wound healing.
embodiment 4have and promote that when injected organism tissue grows the medical sponge of effect, be prepared from (every part of 10g) primarily of following raw materials according: 10 parts, Fructus Benincasae, Herba Ophioglossi 10 parts, Herba Violae japonicae 12 parts, Cacumen Platycladi 14 parts, Semen Cajani 12 parts, Calculus Equi 7 parts, Radix Isatidis 10 parts, the Radix Angelicae Dahuricae 9 parts, Herba Solani Nigri 12 parts, chitin 55 parts, human fibrinogen's appropriate (purchased from Shanghai Institute of Biological Products Co., Ltd., authentication code is the accurate word S10970080 of traditional Chinese medicines).Above-mentioned have promote that the preparation method that when injected organism tissue grows the medical sponge of effect is:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 18 minutes, the decocting in water adding Fructus Benincasae quality 5.5 times, to boiling, filters, and collects filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fries 12 minutes, drenches into vinegar water infiltration 12 minutes, and change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 14 minutes, taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add the water boil of boiled crude drug quality 7 times, continue 12 minutes, then add step (2) (3) made crude drug, change little fire and decoct 26 minutes, collecting by filtration filtrate, and mix with step (1) gained filtrate, concentrated 18 minutes of heating, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stirs, make the chitin solution that concentration is 3%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, is sub-packed in container, add Fibrinogen again, lyophilization, makes the spongy layer that thickness is 6mm, by the mixed liquid dipping 9 minutes of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
embodiment 5have and promote that when injected organism tissue grows the medical sponge of effect, be prepared from (every part of 10g) primarily of following raw materials according: 8.5 parts, Fructus Benincasae, Herba Ophioglossi 9.5 parts, Herba Violae japonicae 11 parts, Cacumen Platycladi 13 parts, Semen Cajani 11.5 parts, Calculus Equi 6 parts, Radix Isatidis 9 parts, the Radix Angelicae Dahuricae 7.5 parts, Herba Solani Nigri 10.5 parts, chitin 50 parts, human fibrinogen's appropriate (purchased from Shanghai Institute of Biological Products Co., Ltd., authentication code is the accurate word S10970080 of traditional Chinese medicines).Above-mentioned have promote that the preparation method that when injected organism tissue grows the medical sponge of effect is:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 16 minutes, the decocting in water adding Fructus Benincasae quality 5 times, to boiling, filters, and collects filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fries 10 minutes, drenches into vinegar water infiltration 10 minutes, and change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 12 minutes, taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add the water boil of boiled crude drug quality 6.5 times, continue 12 minutes, then add step (2) (3) made crude drug, change little fire and decoct 24 minutes, collecting by filtration filtrate, and mix with step (1) gained filtrate, concentrated 15 minutes of heating, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stirs, make the chitin solution that concentration is 2%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, is sub-packed in container, add Fibrinogen again, lyophilization, makes the spongy layer that thickness is 5mm, by the mixed liquid dipping 8 minutes of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Benincasae: base is former: be the fruit of cucurbitaceous plant Fructus Benincasae.Nature and flavor: sweet in the mouth; Light; Cold nature.Gui Jing: return lung; Intestine and small intestine; Urinary bladder channel.Function cures mainly: diuresis; Heat clearing away; Reduce phlegm; Promote the production of body fluid; Removing toxic substances.Main edema distension; Gonorrhea; Foot gas; Phlegm dyspnea; Summer-heat is unhappy; Quench one's thirst; Carbuncle; Anal fistula; And separate borax poison; Ichthyotoxin; Alcoholism.
Herba Ophioglossi: base is former: be the whole herb with root of Ophioglossaceae plant Herba Ophioglossi, blunt nosed Herba Ophioglossi, Herba Ophioglossi, Ophioglossum thermale and heart leaf Herba Ophioglossi.Nature and flavor: bitter; Sweet; Be slightly cold.Gui Jing: Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation to remove blood stasis.Main carbuncle sore tumefacting virus; Scabies itching over the body; Traumatic injury; Swelling and pain due to blood stasis; Venom; Burn and scald; The stagnant stomachache of the stasis of blood.
Herba Violae japonicae: base is former: be the herb of Violaceae plant lobus cardiacus common violet.Nature and flavor: bitter in the mouth; Micro-pungent; Cold in nature.Gui Jing: liver; Spleen channel.Function cures mainly: heat-clearing and toxic substances removing; Blood stasis dispelling evacuation of pus; Removing heat from blood liver heat removing.Main swollen ulcer drug; Acute mastitis; Acute appendicitis hematochezia; Suppurative osteomyelitis; Jaundice; Conjunctival congestion and swelling pain; Scrofula; Traumatic hemorrhage; Snakebite.
Cacumen Platycladi: nature and flavor with return through: bitter, puckery, cold.Return lung, liver, spleen channel.Function with cure mainly: cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, growing and blacking hair.For spitting blood, epistaxis, spitting of blood, has blood in stool, metrostaxis, cough due to lung-heat, heat in blood alopecia, early whitening of beard and hair.
Semen Cajani: base is former: be the seed of leguminous plant Semen Cajani.Nature and flavor: pungent, puckery; Flat; Nontoxic.Gui Jing: liver; Spleen channel.Function cures mainly: dampness removing, detumescence, dissipating blood stasis, hemostasis.Main air pain of dampness syndrome, traumatic injury, epistaxis, has blood in stool, furuncle toxic swelling, prolonged lochia, edema, icterohepatitis.
Calculus Equi: base is former: be the gastrointestinal tract calculus of equine equus horse.Composition: the calculus phosphoric acid magnesium in horse gastrointestinal, calcium carbonate, magnesium carbonate etc.Ammoniomagnesium phosphate, newberyite.The property of medicine: sweet, salty, cool, mild toxicity.GUIXIN, Liver Channel.Function cures mainly: relieving convulsionly reduce phlegm, heat-clearing and toxic substances removing.Cure mainly infantile convulsion epilepsy, hematemesis and epistaxis, phlegm-heat cough, variola.
Radix Isatidis: base is former: be the root of cruciferae isatis.Nature and flavor: bitter; Cold.Gui Jing: liver; Stomach warp.Function cures mainly: heat clearing away; Removing toxic substances; Removing heat from blood; Sore-throat relieving.Main maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer swells; Chickenpox; Measles; Hepatitis; Influenza.
The Radix Angelicae Dahuricae: base is former: be the root of samphire Angelica dahurica, angelica anomala, Radix angelicae dahuricae or Yunnan cattle Radix Saposhnikoviae.Acrid in the mouth, warm in nature.For inducing sweat, dispel-wind drug.There is expelling wind and removing dampness, understand things pain-stopping, effect of detumescence and apocenosis, for headache of catching a cold, nasal obstruction, nasal sinusitis.
Herba Solani Nigri: base is former: be the herb of plant of Solanaceae Herba Solani Nigri.Chemical analysis: determine alkali, Saponin, vitamin C, resin containing solanine, Australia's solanamine, Herba Solani Nigri.Nature and flavor: bitter, cold.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and detumescence.Main furuncle; Carbuncle; Erysipelas; Osteopatia sprain; Chronic tracheitis; Oedema due to nephritis.
Chitin: base is former: be extract from the carapace such as shrimp, Eriocheir sinensis containing amino, the straight-chain polysaccharide how to be polymerized by N-acetyl group-D-glucopyranose amine is the main organic principle of shrimp, Eriocheir sinensis shell, also referred to as chitin, chitin.Effect: Weight-reducing and lipid-lowering; Reduce blood pressure; Blood sugar lowering; Strengthening liver function; Anticancer shifts; Slow down aging.
Fibrinogen: base is former: be a kind of protein with coagulation function synthesized by liver.Fibrin is in coagulation process, the monomeric protein that thrombin excises fibrinopeptide A and B in fibrinogen and generates.Briefly, be exactly a kind of protein relevant with blood coagulation, i.e. thrombin.(the present invention's Fibrinogen used is human fibrinogen, and purchased from Shanghai Institute of Biological Products Co., Ltd., authentication code is the accurate word S10970080 of traditional Chinese medicines).
test example 1gained of the present invention has the clinical practice that promotion when injected organism tissue grows the medical sponge (embodiment 5) of effect:
Choose crowd: in May ,-2015 in August, 2014, in three hospitals screening traumatic patients 162 example, age 6-72 year, 41.3 ± 2.0 years old mean age, wherein male patient 83 example, female patient 79 example.All patients all follow the principle of voluntariness, and can obey treatment completely and follow up a case by regular visits to.
Before test, patient is divided into two groups at random, experimental group 90 example and matched group 72 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group uses products obtained therefrom of the present invention to carry out hemostasis wrapping; Matched group uses medical polyurethane sponge to carry out hemostasis wrapping.Treatments period carries out Continuous Observation to two groups of patients, record symptom and wound healing time.
Clinical effectiveness: two groups of patient treatment outcome are as shown in table 1:
Known by contrasting, the experimental group patient wound required time that heals is shorter, and the granulation tissue of adhesion new life, reduce the generation of cicatrix, illustrates that products obtained therefrom of the present invention can promote that when injected organism tissue grows, minimizing patient suffering.
The Chinese medicine used in the present invention, Fructus Benincasae, Calculus Equi heat-clearing and toxic substances removing, Herba Ophioglossi promoting blood circulation to remove blood stasis, the liver heat removing of Herba Violae japonicae removing heat from blood, Cacumen Platycladi cooling blood for hemostasis, Semen Cajani detumescence hemostasis, Radix Isatidis removing heat from blood sore-throat relieving, Radix Angelicae Dahuricae understand things pain-stopping, Herba Solani Nigri promoting blood circulation and detumescence, multiple medical material effect is worked in coordination with, and take chitin as substrate, make medical sponge, the effect promoting when injected organism tissue growth can be played.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. have and promote that when injected organism tissue grows the medical sponge of effect, it is characterized in that, be prepared from primarily of following raw materials according, be mass parts: Fructus Benincasae 6-11; Herba Ophioglossi 7-12; Herba Violae japonicae 9-13; Cacumen Platycladi 10-16; Semen Cajani 10-13; Calculus Equi 4-8; Radix Isatidis 6-12; Radix Angelicae Dahuricae 5-10; Herba Solani Nigri 8-13; Chitin 40-60; Fibrinogen is appropriate.
2. have as claimed in claim 1 and promote that when injected organism tissue grows the medical sponge of effect, it is characterized in that, Fructus Benincasae 7-10; Herba Ophioglossi 9-10; Herba Violae japonicae 10-12; Cacumen Platycladi 12-14; Semen Cajani 11-12; Calculus Equi 5-7; Radix Isatidis 8-10; Radix Angelicae Dahuricae 6-9; Herba Solani Nigri 9-12; Chitin 45-55; Fibrinogen is appropriate.
3. have as claimed in claim 1 and promote that when injected organism tissue grows the medical sponge of effect, it is characterized in that, Fructus Benincasae 8.5; Herba Ophioglossi 9.5; Herba Violae japonicae 11; Cacumen Platycladi 13; Semen Cajani 11.5; Calculus Equi 6; Radix Isatidis 9; The Radix Angelicae Dahuricae 7.5; Herba Solani Nigri 10.5; Chitin 50; Fibrinogen is appropriate.
4. the preparation method of the medical sponge as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Fructus Benincasae is removed impurity, be cut into bulk, be sprinkled into Sal and rice wine moistening 12-20 minute is (preferred: moistening 14-18 minute; Be more preferably: moistening 16 minutes), add decocting in water to boiling, filter, collect filtrate;
(2) get Semen Cajani removing impurity, be placed in parch container, big fire stir-fry 6-14 minute (preferred: slow fire stir-fries 8-12 minute; Be more preferably: slow fire stir-fries 10 minutes), drench into vinegar water infiltration, change the micro-stir-fry of little fire to dry, taking-up cools;
(3) get Calculus Equi remove impurity, put into thermokalite water and soak 8-16 minute (preferably: soak 10-14 minute; Be more preferably: soak 12 minutes), taking-up clear water is cleaned, and is placed in smokeless stove fire to be calcined to crisp, puts into hydromel while hot and infiltrates, take out and cool and grinds into powder;
(4) Herba Ophioglossi, Herba Violae japonicae, Cacumen Platycladi, Radix Isatidis, the Radix Angelicae Dahuricae and Herba Solani Nigri are cleaned remove impurity, be placed in marmite, add water boil, continue 12 minutes, add step (2) (3) made crude drug again, change little fire and decoct 20-28 minute (preferably: little fire decocts 22-26 minute; Be more preferably: little fire decocts 24 minutes), collecting by filtration filtrate, and mix with step (1) gained filtrate, heating is concentrated, obtains concentrated solution;
(5) chitin is dissolved in propionic acid solution, stir, make the chitin solution (preferred: to make the chitin solution that concentration is 2%) that concentration is 1%-3%, add step (4) the gained concentrated solution mixing of 2/5, ultrasonic wave concussion sloughs bubble, be sub-packed in container, add Fibrinogen again, lyophilization, makes spongy layer, by the mixed liquid dipping 6-10 minute of spongy layer ammonia and methanol, clean up with distilled water again, step (4) the gained concentrated solution adding 3/5 soaks into, and lyophilizing is also sterilized, and makes medical sponge.
5. the preparation method of medical sponge as claimed in claim 4, is characterized in that, step (1) amount of water is that the 4-6 of Fructus Benincasae quality is doubly (preferred: amount of water is 4.5-5.5 times of Fructus Benincasae quality; Be more preferably: amount of water is 5 times of Fructus Benincasae quality).
6. the preparation method of medical sponge as claimed in claim 4, is characterized in that, step (2) is drenched into vinegar water infiltration 5-15 minute (preferred: to drench into vinegar water infiltration 8-12 minute; Be more preferably: drench into vinegar water infiltration 10 minutes).
7. the preparation method of medical sponge as claimed in claim 4, is characterized in that, the 5-8 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 6-7 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 6.5 times of boiled crude drug quality).
8. the preparation method of medical sponge as claimed in claim 4, is characterized in that, it is (preferred: the concentrated 12-18 minute of heating that step (4) heating concentrates 10-20 minute; Be more preferably: concentrated 15 minutes of heating).
9. the preparation method of medical sponge as claimed in claim 4, it is characterized in that, the thickness of step (5) spongy layer is that 4-6mm(is preferred: the thickness of spongy layer is 5mm).
10. the preparation method of medical sponge as claimed in claim 4, is characterized in that, step (5) was by spongy layer ammonia and methanol mixed liquid dipping 7-9 minute (preferred: the mixed liquid dipping 8 minutes by spongy layer ammonia and methanol).
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| CN201510688875.XA CN105233323A (en) | 2015-10-23 | 2015-10-23 | Medical sponge with effect of promoting organism tissue growth and manufacturing method of medical sponge |
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| WO2012030805A2 (en) * | 2010-08-30 | 2012-03-08 | President And Fellows Of Harvard College | A high strength chitin composite material and method of making |
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| US4600574A (en) * | 1984-03-21 | 1986-07-15 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Method of producing a tissue adhesive |
| CN1485097A (en) * | 2003-08-22 | 2004-03-31 | 北京益而康生物工程开发中心 | Prepration process for biologic hemostatic sponge material |
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Address after: Kowloon Road 678000 in Yunnan province Baoshan City Longyang District No. 95 Yuanfeng District 4 Building 2-102 Applicant after: Xu Aijun Address before: Pingyin County, Ji'nan City, Shandong province 250400 Hongfanchi town of Yan Village No. 21 Applicant before: Xu Aijun |
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Application publication date: 20160113 |