CN105561373A - Medical swelling-and-pain-relieving film - Google Patents
Medical swelling-and-pain-relieving film Download PDFInfo
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- CN105561373A CN105561373A CN201510994597.0A CN201510994597A CN105561373A CN 105561373 A CN105561373 A CN 105561373A CN 201510994597 A CN201510994597 A CN 201510994597A CN 105561373 A CN105561373 A CN 105561373A
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- parts
- radix
- alleviating pain
- medical film
- reducing swelling
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Abstract
The present invention discloses a medical swelling-and-pain-relieving film which is mainly prepared from the following materialsby mass: 35-45 parts of chitosan; 18-26 parts of a polyurethane prepolymer; 1-3 parts of dibutyltin dilaurate; 2-5 parts of polyacrylamide; 8-13 parts of prunella spike; 6-9 parts of gastrodia elata; 9-11 parts of radix paeoniae rubra; 10-13 parts of radix cyathulae; 5-10 parts of Marasmius androsaceus; 4-7 parts of Chloranthus serratus; 6-9 parts of Stahlianthus involucratus; 2-5 parts of sodium sulfate; 7-10 parts of speranskia tuberculata and 6-8 parts of curcuma aromatica. The medical swelling-and-pain-relieving film can effectively prevent wound infection, reduces scars, and has the effects of relieving swelling and pains, astringing sores and promoting tissue regeneration.
Description
Technical field
The present invention relates to field of medical materials, particularly relate to a kind of medical film of reducing swelling and alleviating pain.
Background technology
Medical film is a kind of healthy prevention equipment that hospital uses when performing the operation.Medical film can stop the antibacterial on skin, because the sterilization in patient's art district completes in fact at short notice, can only remove the antibacterial on surface, the antibacterial of some pore depths likely moves out in operation process, sticks medical film and just plays and prevent the effect of antibacterial.Existing medical film existence lacks flexibility, ventilative bad, acts on the problems such as single.
Publication No. CN104877332A(application number 201510262703.6) Chinese patent literature disclose a kind of preparation method of medical film, its method for making is for take each component by weight ratio; Put in reactor by each component, in nitrogen atmosphere, be heated to 65-70 DEG C, constantly stir under the rotating speed of 110-130r/min, reaction 2-3h, obtains preform; Obtained preform is sent into double screw extruder, extrusion temperature 190-205 DEG C, screw speed 45-51Hz, twin-screw extrusion batten, through water-cooled, air-dry, pelletizing, obtains master batch; Gained master batch is extruded blown film in plastic film blowing machine, namely obtains medical film.Publication No. CN105038017A(application number 201510440415.5) Chinese patent literature disclose a kind of medical thin-film material, with Corvic and epoxy resin for raw material, add lubricant, corn starch, sensitizer, surfactant and antitack agent again, its component is respectively by weight: Corvic 40-50 part; Epoxy resin 20-30 part; Lubricant 1-3 part; Corn starch 5-8 part; Sensitizer 0.5-1.5 part; Surfactant 2-4 part; Antitack agent 0.8-1.3 part.Publication No. CN103341217A(application number 201310232435.4) Chinese patent literature disclose a kind of for preventing the preparation method of the thin film of postoperative tissue adhesion.Step is as follows: mixed with chitosan and Polyethylene Glycol by L-glutamic acid, then by L-glutamic acid/chitosan/polyglycol solution in 25 ~ 50 DEG C, under vacuum or moving air, drying prepares L-glutamic acid/chitosan/Polyethylene Glycol semi-intercrossing network thin film, the anti-adhesion membrane that after drying availability matter is stable after deionized water rinsing.
Medical film in the market, act on comparatively single, the effect in antiphlogistic antibacterial, hemostasis etc. awaits further raising, therefore needs to strengthen research in this respect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide the medical film of the non-stimulated reducing swelling and alleviating pain of a kind of good biocompatibility, use safety.
Technical scheme of the present invention is:
A medical film for reducing swelling and alleviating pain, is prepared from primarily of following raw materials according, is mass parts: chitosan 35-45; Base polyurethane prepolymer for use as 18-26; Dibutyl tin laurate 1-3; Polyacrylamide 2-5; Spica Prunellae 8-13; Rhizoma Gastrodiae 6-9; Radix Paeoniae Rubra 9-11; Radix Cyathulae 10-13; Marasmius equicrinis Muell. 5-10; Radix Chloranthi Serrati 4-7; Rhizoma Stahlianthi Involucrati 6-9; Natrii Sulfas 2-5; Herba speranskiae tuberculatae 7-10; Radix Curcumae 6-8.
Preferred version is, chitosan 38-42; Base polyurethane prepolymer for use as 20-24; Dibutyl tin laurate 1.5-2.5; Polyacrylamide 3-4; Spica Prunellae 9-12; Rhizoma Gastrodiae 7-8; Radix Paeoniae Rubra 9.5-10.5; Radix Cyathulae 11-12; Marasmius equicrinis Muell. 6-9; Radix Chloranthi Serrati 5-6; Rhizoma Stahlianthi Involucrati 7-8; Natrii Sulfas 3-4; Herba speranskiae tuberculatae 8-9; Radix Curcumae 6.5-7.5.
More preferably, chitosan 40; Base polyurethane prepolymer for use as 22; Dibutyl tin laurate 2; Polyacrylamide 3.5; Spica Prunellae 10.5; Rhizoma Gastrodiae 7.5; Radix Paeoniae Rubra 10; Radix Cyathulae 11.5; Marasmius equicrinis Muell. 7.5; Radix Chloranthi Serrati 5.5; Rhizoma Stahlianthi Involucrati 7.5; Natrii Sulfas 3.5; Herba speranskiae tuberculatae 8.5; Radix Curcumae 7.
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, step is as follows:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, it is (preferred: to infiltrate 18-24 minute to add vinegar water infiltration 16-26 minute; Be more preferably: infiltrate 21 minutes), take out and be placed in parch container, be sprinkled into fine salt and mix thoroughly, slow fire is fried and is turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice after filtration, smashed by Natrii Sulfas, add fresh radish juice mixing, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes and sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, 12-24 minute is soaked (preferably: soak 16-20 minute with washing water of rice; Be more preferably: soak 18 minutes), take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, decoct with water to boiling, continue 18-28 minute (preferred: to continue 20-26 minute; Be more preferably: continue 23 minutes), filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, and add water and again decoct 20 minutes, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath for reaction 1-3 hour (preferred: reaction 1.5-2.5 hour; Be more preferably: react 2 hours), make preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, the consumption of step (1) fine salt is that the 0.2-0.5 of raw materials quality is doubly (preferred: the consumption of fine salt is 0.3-0.4 times of raw materials quality; Be more preferably: the consumption of fine salt is 0.35 times of raw materials quality).
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, the consumption of step (2) fresh radish juice is that the 3-5 of saltcake quality is doubly (preferred: the consumption of fresh radish juice is 3.5-4.5 times of saltcake quality; Be more preferably: the consumption of fresh radish juice is 4 times of saltcake quality).
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, it is (preferred: to pulverize 140-160 mesh sieve that step (2) pulverized 120-180 mesh sieve; Be more preferably: pulverized 150 mesh sieves).
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, step (3) Steam by water bath 10-20 minute is (preferred: Steam by water bath 12-18 minute; Be more preferably: Steam by water bath 15 minutes).
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, step (4) twice amount of water is the 5-8 of boiled raw materials quality doubly (preferably: twice amount of water is the 6-7 of boiled raw materials quality doubly; Be more preferably: 6.5 times that twice amount of water is boiled raw materials quality).
The preparation method of the medical film of described a kind of reducing swelling and alleviating pain, the temperature of step (5) heating in water bath be 40-80 DEG C (preferred: the temperature of heating in water bath is 50-70 DEG C; Be more preferably: the temperature of heating in water bath is 60 DEG C).
The medical film good biocompatibility of a kind of reducing swelling and alleviating pain provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention effectively can promote wound healing, reduces patient suffering;
2, products obtained therefrom good springiness of the present invention, air permeable effect is good, little to the zest of skin;
3, products obtained therefrom of the present invention is with low cost, easy to use, and degradable is pollution-free.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
The medical film of embodiment 1 one kinds of reducing swelling and alleviating pain, is prepared from (every part of 10g) primarily of following raw materials according: chitosan 35 parts, base polyurethane prepolymer for use as 18 parts, dibutyl tin laurate 1 part, polyacrylamide 2 parts, Spica Prunellae 8 parts, 6 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 9 parts, Radix Cyathulae 10 parts, Marasmius equicrinis Muell. 5 parts, Radix Chloranthi Serrati 4 parts, Rhizoma Stahlianthi Involucrati 6 parts, 2 parts, Natrii Sulfas, Herba speranskiae tuberculatae 7 parts, Radix Curcumae 6 parts.The preparation method of the medical film of above-mentioned a kind of reducing swelling and alleviating pain is:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, add vinegar water infiltration 16 minutes, take out and be placed in parch container, the fine salt being sprinkled into raw materials quality 0.2 times is mixed thoroughly, and slow fire is fried and turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice, smashed by Natrii Sulfas after filtration, add the fresh radish juice mixing of saltcake quality 3 times, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes 120 mesh sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, soak 12 minutes with washing water of rice, take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath 10 minutes, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae are cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, add the soak by water of boiled raw materials quality 5 times to boiling, continue 18 minutes, filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, the water adding boiled raw materials quality 5 times decocts 20 minutes again, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath to 40 DEG C reaction 1 hour, makes preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
The medical film of embodiment 2 one kinds of reducing swelling and alleviating pain, is prepared from (every part of 10g) primarily of following raw materials according: chitosan 45 parts, base polyurethane prepolymer for use as 26 parts, dibutyl tin laurate 3 parts, polyacrylamide 5 parts, Spica Prunellae 13 parts, 9 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 11 parts, Radix Cyathulae 13 parts, Marasmius equicrinis Muell. 10 parts, Radix Chloranthi Serrati 7 parts, Rhizoma Stahlianthi Involucrati 9 parts, 5 parts, Natrii Sulfas, Herba speranskiae tuberculatae 10 parts, Radix Curcumae 8 parts.The preparation method of the medical film of above-mentioned a kind of reducing swelling and alleviating pain is:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, add vinegar water infiltration 26 minutes, take out and be placed in parch container, the fine salt being sprinkled into raw materials quality 0.5 times is mixed thoroughly, and slow fire is fried and turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice, smashed by Natrii Sulfas after filtration, add the fresh radish juice mixing of saltcake quality 5 times, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes 180 mesh sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, soak 24 minutes with washing water of rice, take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath 20 minutes, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae are cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, add the soak by water of boiled raw materials quality 8 times to boiling, continue 28 minutes, filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, the water adding boiled raw materials quality 8 times decocts 20 minutes again, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath to 80 DEG C reaction 3 hours, makes preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
Typical case: xxx, male, 58 years old.Patient falls down snowy day by bike, causes fracture of thigh, when carrying out fracture reduction operation, uses the medical film of a kind of reducing swelling and alleviating pain of gained of the present invention, bleeding amount of wound reduce, in postoperative three days, wound without infection, with skin without adhesion, postoperative one month, fracture healed substantially, can light activity.
The medical film of embodiment 3 one kinds of reducing swelling and alleviating pain, is prepared from (every part of 10g) primarily of following raw materials according: chitosan 38 parts, base polyurethane prepolymer for use as 20 parts, dibutyl tin laurate 1.5 parts, polyacrylamide 3 parts, Spica Prunellae 9 parts, 7 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 9.5 parts, Radix Cyathulae 11 parts, Marasmius equicrinis Muell. 6 parts, Radix Chloranthi Serrati 5 parts, Rhizoma Stahlianthi Involucrati 7 parts, 3 parts, Natrii Sulfas, Herba speranskiae tuberculatae 8 parts, Radix Curcumae 6.5 parts.The preparation method of the medical film of above-mentioned a kind of reducing swelling and alleviating pain is:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, add vinegar water infiltration 18 minutes, take out and be placed in parch container, the fine salt being sprinkled into raw materials quality 0.3 times is mixed thoroughly, and slow fire is fried and turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice, smashed by Natrii Sulfas after filtration, add the fresh radish juice mixing of saltcake quality 3.5 times, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes 140 mesh sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, soak 16 minutes with washing water of rice, take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath 12 minutes, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae are cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, add the soak by water of boiled raw materials quality 6 times to boiling, continue 20 minutes, filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, the water adding boiled raw materials quality 6 times decocts 20 minutes again, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath to 50 DEG C reaction 1.5 hours, makes preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
The medical film of embodiment 4 one kinds of reducing swelling and alleviating pain, is prepared from (every part of 10g) primarily of following raw materials according: chitosan 42 parts, base polyurethane prepolymer for use as 24 parts, dibutyl tin laurate 2.5 parts, polyacrylamide 4 parts, Spica Prunellae 12 parts, 8 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 10.5 parts, Radix Cyathulae 12 parts, Marasmius equicrinis Muell. 9 parts, Radix Chloranthi Serrati 6 parts, Rhizoma Stahlianthi Involucrati 8 parts, 4 parts, Natrii Sulfas, Herba speranskiae tuberculatae 9 parts, Radix Curcumae 7.5 parts.The preparation method of the medical film of above-mentioned a kind of reducing swelling and alleviating pain is:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, add vinegar water infiltration 24 minutes, take out and be placed in parch container, the fine salt being sprinkled into raw materials quality 0.4 times is mixed thoroughly, and slow fire is fried and turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice, smashed by Natrii Sulfas after filtration, add the fresh radish juice mixing of saltcake quality 4.5 times, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes 160 mesh sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, soak 20 minutes with washing water of rice, take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath 18 minutes, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae are cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, add the soak by water of boiled raw materials quality 7 times to boiling, continue 26 minutes, filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, the water adding boiled raw materials quality 7 times decocts 20 minutes again, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath to 70 DEG C reaction 2.5 hours, makes preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
Typical case: xxx, women, 31 years old.Patient is an athlete, causing tendon rupture because of carelessness because taking exercise, being admitted to hospital and being treated surgically, in therapeutic process, use the medical film of a kind of reducing swelling and alleviating pain of gained of the present invention, thin film and wound surface are fitted closely, amount of bleeding obviously reduces, and operation terminates rear clinical observation, to skin without adhesion, wound is without redness, follow up a case by regular visits to two months, patient heals gradually, recovers good.
The medical film of embodiment 5 one kinds of reducing swelling and alleviating pain, is prepared from (every part of 10g) primarily of following raw materials according: chitosan 40 parts, base polyurethane prepolymer for use as 22 parts, dibutyl tin laurate 2 parts, polyacrylamide 3.5 parts, Spica Prunellae 10.5 parts, 7.5 parts, Rhizoma Gastrodiae, Radix Paeoniae Rubra 10 parts, Radix Cyathulae 11.5 parts, Marasmius equicrinis Muell. 7.5 parts, Radix Chloranthi Serrati 5.5 parts, Rhizoma Stahlianthi Involucrati 7.5 parts, 3.5 parts, Natrii Sulfas, Herba speranskiae tuberculatae 8.5 parts, Radix Curcumae 7 parts.The preparation method of the medical film of above-mentioned a kind of reducing swelling and alleviating pain is:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, add vinegar water infiltration 21 minutes, take out and be placed in parch container, the fine salt being sprinkled into raw materials quality 0.35 times is mixed thoroughly, and slow fire is fried and turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice, smashed by Natrii Sulfas after filtration, add the fresh radish juice mixing of saltcake quality 4 times, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes 150 mesh sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, soak 18 minutes with washing water of rice, take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath 15 minutes, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae are cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, add the soak by water of boiled raw materials quality 6.5 times to boiling, continue 23 minutes, filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, the water adding boiled raw materials quality 6.5 times decocts 20 minutes again, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath to 60 DEG C reaction 2 hours, makes preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
The pharmacology of the present invention's primary raw material used is as follows:
Spica Prunellae: base is former: be the fruit ear of labiate Spica Prunellae.Nature and flavor with return through: pungent, bitter, cold.Return liver, gallbladder meridian.There is purging liver-fire, improving eyesight, effect of mass dissipating and swelling eliminating.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, acute mastitis, nodules of the breast, distending pain of the breast.
Rhizoma Gastrodiae: base is former: be the tuber of sky section Gastrodia plant Rhizoma Gastrodiae.Composition: Rhizoma Gastrodiae is containing phenols: namely Gastrodine claims gastrodine, gastrodioside, 4-ethoxymethyl phenol, hydroxy benzaldehyde, 3,4-4-dihydroxy benzaldehyde; Aromatic compound: 4-acrinyl methyl ether etc.The property of medicine: sweet, pungent, flat.Return Liver Channel.Function cures mainly: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.
Radix Paeoniae Rubra: base is former: the root of Paeoniaceae plant peony, CHUANSHAO medicine, Paeonia obovata Maxim., hair leaf Paeonia obovata Maxim., Paeonia mairei Lévl., Paeonia anomala and tuber Radix Paeoniae.Nature and flavor: bitter; Be slightly cold.Gui Jing: liver; Spleen channel.Function cures mainly: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.
Radix Cyathulae: nature and flavor with return through sweet, micro-hardship, flat.Return liver, kidney channel.There is eliminating blood stasis and inducing menstruation, easing joint movement, effect of inducing diuresis for treating stranguria syndrome.For amenorrhea leprosy abdominal mass, retention of placenta, injury from falling down, rheumatic arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood.
Marasmius equicrinis Muell.: base is former: be the shoestring of Bai Mo section Marasmius fungus peace Lip river Marasmius.The property of medicine: warm in nature, mildly bitter flavor.Function cures mainly: promoting blood circulation and stopping pain.Cure mainly traumatic injury, fracture pain, migraine, various neuralgia, lumbago and skelalgia, rheumatic arthralgia.
Radix Chloranthi Serrati: base is former: be golden Li Lanke gold chestnut epidendrum Radix Chloranthi Serrati, with root or all herbal medicine.Composition: root contains dihydro burnt Rhizoma Curcumae furan ketenes, cowherb Rhizoma Atractylodis Macrocephalae furan ketenes, chloranthalactone E, F, new acorone, the new acorone of 7-a-hydroxyl, acorone, Rhizoma Curcumae furan ether ketone, different Rhizoma Curcumae furanodiene etc.The property of medicine: bitter, flat, poisonous.Nature and flavor with return through: pungent, warm.Poisonous.There is relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping, effect of subduing swelling and detoxicating.For traumatic injury, lumbago, skelalgia of rheumatism, furuncle swelling toxin, venom.Compatibility and incompatibility of drugs: trichosanthes seed for oral administration should be careful, the careful clothes of anemia of pregnant woman.For oral administration excessive, can occur vomiting, thirsty, headache, dim eyesight, uncomfortable in chest, tetany, conjunctival congestion, gums turns black, and nervous cardiopalmus, the poisoning symptoms such as obnubilation, severe patient can cause death.
Rhizoma Stahlianthi Involucrati: base is former: be the block root welding technology of zingiberaceous plant soil state seven.Nature and flavor: acrid in the mouth; Micro-hardship; Warm in nature.Gui Jing: the heart; Spleen channel.Function cures mainly: dissipating blood stasis; Pain relieving; Hemostasis.Main traumatic injury stasis of blood pain; Rheumatic ostalgia; Hematemesis and epistaxis; Menorrhagia; Traumatic hemorrhage.
Natrii Sulfas: base is former: the refining crystallization obtained through boiling-off for mineral Natrii Sulfas.Nature and flavor: arduous salty, cold.Gui Jing: enter stomach, large intestine channel.Function cures mainly: purge heat, and moisturizes, softening the hard mass.Control excess-heat to stagnate, abdominal distention constipation, retention of phlegm gathers, and mouth is red hides from view, erysipelas, carbuncle.
Herba speranskiae tuberculatae: base is former: be the herb of euphorbia plant speranskia tuberculata.Nature and flavor: pungent; Warm in nature.Gui Jing: lung; Liver Channel.Function cures mainly: expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Dissipating blood stasis for subsidence of swelling; Removing toxic substances ophthalmalgia.Main air pain of dampness syndrome; Muscles and bones contracture; The disturbance of lower legs due to pathogenic cold and dampness; Lumbar strain; Paralysis; Amenorrhea; Eczema scrotum; Furuncle toxic swelling.
Radix Curcumae: base is former: be the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Property pungent, bitter, cold.Return liver, the heart, lung meridian.Can regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be generally used for amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Chitosan: be that the chitin extensively existed by nature obtains through deacetylation, have excellent biological functionality, the compatibility, blood compatibility, safety and microbic resolvability etc., its physiologically active shows as and can control cholesterol, Antibacterial activity, prevention and corntrol hypertension, absorption and excretion heavy metal, immune effect.(the present invention's chitosan used all purchased from Zhejiang Jin Ke pharmaceutcal corporation, Ltd).
Base polyurethane prepolymer for use as: polyurethane reacts formed high molecular polymer under certain condition by polyisocyanates and polyethers or PEPA.The performed polymer of polyurethane is briefly the reactable semi-finished product that polyisocyanates and polyhydric alcohol control certain proportion react and obtain.Base polyurethane prepolymer for use as is widely used in the numerous areas such as polyurethane adhesive, coating, elastomer, foam and fiber.(the present invention's base polyurethane prepolymer for use as used all purchased from Liming Research Institute of Chemical Industry Co., Ltd.).
The clinical practice of the medical film (embodiment 5) of a kind of reducing swelling and alleviating pain of test example 1 gained of the present invention:
Choose object: in April ,-2015 in June, 2014, in four hospital random selecting fire victim 100 examples, wherein male patient 50 example, female patient 50 example, the range of age 20-58 year between, 29.4 ± 1.6 years old mean age, wherein first degree burn patient 36 example, second degree burn patient 64 example.
Test method: patient is divided into two groups at random, experimental group 75 example and matched group 25 routine, two groups in sex, age, the state of an illness etc. without significant difference.Matched group patient uses general surgery thin film, and by washing wound surface, sterilization, evened up by general surgery thin film after suck dry moisture, lid compression is attached on wound surface and wraps up, once a day, until healing; Experimental group patient uses the medical film of a kind of reducing swelling and alleviating pain of gained of the present invention, wraps up with identical maneuver process.Treatments period observes wound surface cicatrix situation, infection conditions and wound healing time.
Result of the test: two groups of patient test's results are as shown in table 1:
As shown in Table 1, in experimental group patient treatment procedure, traumatic infection only has 1 example, matched group patient has 9 examples to infect, and the wound healing of experimental group is effective, healing time comparatively matched group is compared and is also obviously shortened, prove that products obtained therefrom of the present invention effectively can avoid wound infection, reduce cicatrix, there is effect of reducing swelling and alleviating pain, expelling pus and promoting granulation.
In the present invention with chitosan and base polyurethane prepolymer for use as substrate, then be aided with various raw material of Chinese medicine, by its effective ingredient perfect adaptation, make medical film, can effectively control traumatic infection, Promotive union, reduce the effect of scar hyperplasia, clinic is promoted.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. a medical film for reducing swelling and alleviating pain, is characterized in that, is prepared from primarily of following raw materials according, is mass parts: chitosan 35-45; Base polyurethane prepolymer for use as 18-26; Dibutyl tin laurate 1-3; Polyacrylamide 2-5; Spica Prunellae 8-13; Rhizoma Gastrodiae 6-9; Radix Paeoniae Rubra 9-11; Radix Cyathulae 10-13; Marasmius equicrinis Muell. 5-10; Radix Chloranthi Serrati 4-7; Rhizoma Stahlianthi Involucrati 6-9; Natrii Sulfas 2-5; Herba speranskiae tuberculatae 7-10; Radix Curcumae 6-8.
2. the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 1, is characterized in that, chitosan 38-42; Base polyurethane prepolymer for use as 20-24; Dibutyl tin laurate 1.5-2.5; Polyacrylamide 3-4; Spica Prunellae 9-12; Rhizoma Gastrodiae 7-8; Radix Paeoniae Rubra 9.5-10.5; Radix Cyathulae 11-12; Marasmius equicrinis Muell. 6-9; Radix Chloranthi Serrati 5-6; Rhizoma Stahlianthi Involucrati 7-8; Natrii Sulfas 3-4; Herba speranskiae tuberculatae 8-9; Radix Curcumae 6.5-7.5.
3. the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 1, is characterized in that, chitosan 40; Base polyurethane prepolymer for use as 22; Dibutyl tin laurate 2; Polyacrylamide 3.5; Spica Prunellae 10.5; Rhizoma Gastrodiae 7.5; Radix Paeoniae Rubra 10; Radix Cyathulae 11.5; Marasmius equicrinis Muell. 7.5; Radix Chloranthi Serrati 5.5; Rhizoma Stahlianthi Involucrati 7.5; Natrii Sulfas 3.5; Herba speranskiae tuberculatae 8.5; Radix Curcumae 7.
4. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) get Spica Prunellae and Marasmius equicrinis Muell. cleans remove impurity, it is (preferred: to infiltrate 18-24 minute to add vinegar water infiltration 16-26 minute; Be more preferably: infiltrate 21 minutes), take out and be placed in parch container, be sprinkled into fine salt and mix thoroughly, slow fire is fried and is turned yellow to raw material surface, and taking-up cools;
(2) get fresh Radix Raphani squeezing extracting juice, obtain fresh radish juice after filtration, smashed by Natrii Sulfas, add fresh radish juice mixing, little fiery heated and boiled, until juice boils dry, taking-up cools, and pulverizes and sieves;
(3) by Rhizoma Gastrodiae, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Stahlianthi Involucrati and Radix Curcumae removing impurity, 12-24 minute is soaked (preferably: soak 16-20 minute with washing water of rice; Be more preferably: soak 18 minutes), take out and be cut into block, add rice wine and mix thoroughly, be placed in steamer, Steam by water bath, taking-up cools;
(4) Radix Chloranthi Serrati and Herba speranskiae tuberculatae cleaned pulverize, be placed in marmite together with step (1) (3) made raw material, decoct with water to boiling, continue 18-28 minute (preferred: to continue 20-26 minute; Be more preferably: continue 23 minutes), filtering and collecting filter liquid, filtering residue mixes with step (2) made raw material, and add water and again decoct 20 minutes, after filtration, merge twice gained filtrate, heating is concentrated into clear paste;
(5) chitosan is dissolved in the acetum of 5%, make the chitosan solution that concentration is 2%, base polyurethane prepolymer for use as is added dimethyl formamide to dissolve, add the mixing of dibutyl tin laurate, polyacrylamide and chitosan solution, constantly stir with the rotating speed of 180 revs/min, add step (4) gained clear paste, mix homogeneously, heating in water bath for reaction 1-3 hour (preferred: reaction 1.5-2.5 hour; Be more preferably: react 2 hours), make preform;
(6) step (5) gained preform is sent into double screw extruder, under the extrusion temperature of 200 DEG C, through water-cooled, air-dry, pelletizing, make master batch, master batch calendering formation, obtain a kind of medical film of reducing swelling and alleviating pain.
5. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 4, is characterized in that, the consumption of step (1) fine salt is that the 0.2-0.5 of raw materials quality is doubly (preferred: the consumption of fine salt is 0.3-0.4 times of raw materials quality; Be more preferably: the consumption of fine salt is 0.35 times of raw materials quality).
6. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 4, is characterized in that, the consumption of step (2) fresh radish juice is that the 3-5 of saltcake quality is doubly (preferred: the consumption of fresh radish juice is 3.5-4.5 times of saltcake quality; Be more preferably: the consumption of fresh radish juice is 4 times of saltcake quality).
7. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 4, is characterized in that, it is (preferred: to pulverize 140-160 mesh sieve that step (2) pulverized 120-180 mesh sieve; Be more preferably: pulverized 150 mesh sieves).
8. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 4, is characterized in that, step (3) Steam by water bath 10-20 minute (preferred: Steam by water bath 12-18 minute; Be more preferably: Steam by water bath 15 minutes).
9. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 4, is characterized in that, step (4) twice amount of water is the 5-8 of boiled raw materials quality doubly (preferably: twice amount of water is the 6-7 of boiled raw materials quality doubly; Be more preferably: 6.5 times that twice amount of water is boiled raw materials quality).
10. the preparation method of the medical film of a kind of reducing swelling and alleviating pain as claimed in claim 4, is characterized in that, the temperature of step (5) heating in water bath be 40-80 DEG C (preferred: the temperature of heating in water bath is 50-70 DEG C; Be more preferably: the temperature of heating in water bath is 60 DEG C).
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106075540A (en) * | 2016-06-15 | 2016-11-09 | 湖州科达化工燃料有限公司 | A kind of medical film with analgesia antibiotic effect |
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